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1960,COC[C@@H1]1CC[C@H1](C(=O)N(CCO)[C@H1]2CCN(C(=O)C3=CC(Cl)=C(Cl)S3)C2)C1 1961,COCC1=CSC(C(=O)N[C@@H1](CNC(=O)C(C)(C)C=2C(C)=NOC=2C)CC(C)C)=C1 1962,O=C(C1=CCN(C(=O)[C@@H1]2CCCSC2)CC1)N(CC3CCC3)CC4CC4 1963,C[C@H1]1CCCC[C@]1(CNC(=O)C2=CCC(C)(C)CC2)NC(=O)CCN(C)CCO 1964,COC(=O)CN1CCN(CC2=CC=C(C3=NC=C(F)C(=N)[NH1]3)S2)CC1 1965,C#CC1=CC=C(CCC(=O)NC23CC(CNC(=O)CC=C=C)(C2)OC3(C)C)C=C1 1966,CC1(C#N)CCN(C(=O)[C@@H1]2C[C@H1](F)CN2C(=O)C3=CC=C(Cl)N=C3F)CC1 1967,CC1=CC(C(=O)N(C)C/C=C/C(=O)N2CC(C)(C)CC[C@H1]2C)=N[NH1]1 1968,CC(C)=CC(=O)N1C[C@@H1]2CCC[C@H1](C1)CN2C(=O)C=3SC=CC=3C(F)F 1969,C#CC[C@@](C)(NC(=O)C=1C=CSC=1Cl)C(=O)N[C@H1]2CCCC3=N[NH1]C=C32 1970,C[C@@H1]1O[C@H1]2CC[C@@]1(C(=O)N[C@H1]3C[C@H1]4C[C@@H1](NC(=O)[C@H1]5CCS(=O)(=O)N5)[C@@H1]3C4)C2 1971,CN(CCCCNC(=O)CC[C@@H1]1CCCOC1)C(=O)C2(F)CCC2 1972,C[C@H1](O)CC(=O)N1CC2(CC(CNC(=O)CN3CCC(C)(C)C3)C2)C1 1973,CCCOCCCC(=O)NCC[C@@H1]1CN(C(=O)CNC(=O)NC)C[C@H1](C)O1 1974,CC(C)OCC(=O)N1C[C@@H1](NC(=O)COC2=CC=CC=C2O)CC13CCCC3 1975,C=CCCOCC(=O)N1CCC2(CC1)CN(C(=O)[C@@]3(C)CNC(=O)C3)C[C@H1](C)O2 1976,C[C@H1]1N(C(=O)CN2C=C(Br)C=C(F)C2=O)CCC13CCOCC3 1977,C=C(C)[C@H1](N[C@H1]1CCC2(CC2)C[C@H1]1C(=O)O)C3=CC=C(F)C(F)=C3 1978,CN=C1[NH1]C=C(C(=O)N2CC[C@@H1]2CNC(=O)C3=C(Br)C=CC(F)=C3C)S1 1979,CCC(C)(C)C(=O)C(=O)NCC[C@H1](C)NC(=O)CC1=CC=C2[NH1]C=CC2=C1 1980,O=C([C@@H1]1CCC[C@H1]1NCC2=CC(Br)=NC=C2F)N3CC[C@H1](CO)[C@H1](F)C3 1981,O=C(CC1=C(F)C=CC=C1F)NC[C@H1]2CC23CCN(C(=O)[C@@H1]4CCOC4)CC3 1982,CN(CCCOCCNC(=O)C=1[NH1]N=NC=1C2CC2)C(=O)CO 1983,C[C@@H1](C=1N=C(C2=CC=CN=C2Cl)N([C@H1]3CCS(=O)(=O)C3)N=1)C4CC4 1984,COC1=CC=C(C(C)(C)C(=O)N(C)C[C@@H1](C)CNC(=O)C=C2CC2)C=C1OC 1985,CCCC1(C(=O)N2C[C@@H1]3CC[C@H1](C2)[C@H1](NC(=O)C=NOC)C3)CCC1 1986,CC(=CC1=CC=CS1)C(=O)N2CCN(C(=O)C3[C@@H1]4COC[C@@H1]34)C[C@@H1]2C5CCCC5 1987,CC1=CC=C(C(=O)C(=O)NC2(CN(C)C(=O)[C@@]3(C)CC(=O)N(C)C3)CC2)C=C1 1988,COC1=CN=CC=C1CCNC(=O)CC2CC3(C2)CN(CC4=NC=CN4C)C3 1989,CNS(=O)(=O)C1=CC=C(Cl)C(C(=O)NS(=O)(=O)CC(C)(C)C(F)(F)F)=C1 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