SMILES O=C(C[C@@H1]1C=CCC1)N[C@H1]2C[C@H1](O)CN(C(=O)C=CC3=C(F)C=CC=C3F)C2 COC1=NC=C(F)C=C1C(=O)N2CC[C@@H1]3CCN(C(=O)CCC4=NC=C(C)[NH1]4)[C@@H1]32 O=C(CO)NCCC(=O)N1CC=C(C(=O)NCC2=CC=CC=C2CO)CC1 COC[C@H1](CC1=CC=CC=C1)N(C)N2CC[C@@H1](N3C4=CC=CC=C4CC[C@H1]3C)C2 CC1=NC(C(=O)N2CC[C@H1](C3CC3)[C@@H1]2C(=O)NCC4CCCCCC4)=CO1 CCC1=NSC=C1NC(=O)[C@@H1](CO)NC(=O)C2=CON=C2C CC1=NC=CN1CCC(=O)N2CCN(C(=O)CNC(=O)[C@@H1](O)C(F)(F)F)CC2 COC(=O)C1=CC=C(OC)N=C1COC(=O)[C@@H1]2CCCN3N=CN=C32 CC1(C)C[C@@H1](C(=O)N2CCC[C@@]23CCCN(C(=O)C4=CSC=C4Cl)C3)CNC1=O CCCC(C)=CC(=O)N1CCOC[C@H1]1CC(=O)NC[C@H1](O)CC2CCCC2 CCN(CC1CCOCC1)C2=NN=C([C@@H1]3CCOC3)N2C[C@H1]4CCCO4 O=C(N[C@@H1]1C[C@@H1]2CN(C(=O)C34CCC(C(F)F)(CC3)C4)C[C@H1]21)C5=CC=C(O)N=C5 O=C(N[C@@H1]1CCCN(CC2=CC=CC(F)=C2[N+1](=O)[O-1])C1)C3=CC=CS3 O=C(CC1=CC(Cl)=CC=C1[N+1](=O)[O-1])N[C@H1]2CN(C(=O)C(F)F)C[C@H1]2CO O=C(NC1CC(F)(CNC(=O)C2=CN=C(O)C(Cl)=C2)C1)C3=CC=C(C4CC4)C=C3 CN(CCN1CCN(C(=O)[C@]2(C)C[C@@H1]2F)CC1)C(=O)CC3=CN=C4N=CC=CN34 O=C(CC1CCOCC1)NCCCN(CCO)C(=O)[C@H1]2CC3=CC=C(Cl)C=C32 CC1=CC=CC(NC(=O)C(=O)N2CC[C@@H1](C(=O)N(C)C)C2)=C1C#N C[C@H1](SC1=CC=C(F)C(F)=C1)C(=O)N2C[C@H1](CC(=O)O)OCC2(C)C C[C@@H1](C(=O)NC[C@@H1]1COCCN(C(=O)/C=C/C=2C=COC=2)C1)C3=CC=C(Cl)C=C3 CCC1(C(=O)N2C[C@@H1](NC(=O)[C@@H1]3CCC4(CCC4)O3)CC5(CCC5)C2)CC1 CON=CC(=O)NC[C@@]1(C)CCN(C(=O)CCC(C)(C)C2=CC=CC=C2)C1 CN(C[C@H1]1CCCN1C(=O)CCCF)C(=O)CCC2=CC=C3OC=NC3=C2 CC(C)(CNC(=O)C1CN([C@@H1]2CCOC2)C1)NC(=O)CC=CC3=CC=CC=C3F C[C@@H1](CO)CCNC(=O)C1=CN2C(=N1)CN(C(=O)C=3N=C4C=CC=CN4N=3)CC2 CCC1=NC=C(C(=O)N2CCC3(CC2)CN(C(=O)[C@H1](C)C(C)(F)F)[C@@H1]3C(C)C)S1 CC1=CN=C(Cl)[NH1]C1=NCC2=CC(O)=NC(CNC(=O)CN3[C@@H1](C)CC[C@H1]3C)=N2 CC1=CC(NC2CCN(S(N)(=O)=O)CC2)=NC(=NCC3=CC=C(CO)C=C3)[NH1]1 CCCNC(=O)CCCC(=O)NC[C@H1](F)CNC(=O)C1=CC=C(C)C=N1 C[C@@H1](C1CCC1)[C@H1](C(=O)NCC2CC2)N3CC4=CC=CC=C4O[C@H1](C)C3 C[C@H1]1[C@H1](NC(=O)CCC2=CC=C(Cl)C=C2)CCCN1CC(=O)N3CCC3 O=C(NCCC1(O)CN(C(=O)C2=CC(Cl)=C(Br)S2)C1)[C@H1]3CCC4=C[NH1]N=C43 CCCCN(CC)C(=O)[C@@H1]1CN(C(=O)CC2CC(C)C2)CCO1 CCC(CC)C1=CN(C[C@@H1](F)CCNC(=O)C(F)(F)C2=CC(C)=CC=N2)N=N1 CC1(CC(=O)NC[C@H1]2CCCN(C(=O)[C@H1]3C[C@@H1]4OC(=O)O[C@@H1]4C3)CC2)CCCC1 CCN(C[C@H1](C)NC(=O)C1=CC=C(C(C)(C)C)C=C1C)C(=O)[C@H1](C)SC(F)(F)F C[C@H1](CCN(C)C(=O)C1=CC=CC(Cl)=C1)NC(=O)[C@H1]2CCC3=NC=CN3C2 CCCCO[C@@H1](C)C(=O)N[C@H1](CNC(=O)C1=CC(Cl)=C(Cl)N1C)C(C)(C)C O=C1CN(CC(=O)N[C@H1]2CN(C(=O)CCNC(=O)CO)C[C@H1]2F)C(=O)N1 CC[C@@H1]1CN(C(=O)C2=NC(OC)=CC=C2C)CC[C@H1]1NC(=O)C=3C(C)=NOC=3C CN1CCOC[C@@H1]1C(=O)NC[C@@H1]2C[C@@H1]3C[C@@H1]3N2C(=O)CN4CCS(=O)CC4 C[C@]1(NC(=O)CC2=CCCCC2)C[C@@H1](NC(=O)C3CC=CC3)C1 C[C@@](CNC(=O)C1=CC=C(Br)C=C1N)(NC(=O)CCCCC2CC2)C3CC3 C1[C@@H1][C@H1](N=C2C=C(Cl)N=C3[NH1][NH1]C(I)=C23)C4CCN1CC4 CC1=CC=CC(C(=O)N2CC3(C2)[C@@H1](NC(=O)[C@@H1]4CC45CCC5)CCS3(=O)=O)=C1F CCCC[C@H1](O)[C@H1](C)C(=O)N1CCC[C@@H1](CNC(=O)COCCF)CC1 COC1(C(=O)NCCCCCCN2C=C([C@@H1]3CCCO3)N=N2)CC1 COC(=O)C[C@]1(O)CCN(C2=NN=C(C=3C=NSN=3)N2CCC#N)C1 CC(=O)NCCCCCC(=O)NCC1CC(NC(=O)C2=CN=C3[NH1]C=NC3=C2)C1 CCC(C)(C)N[C@@H1](C)C(=O)N1CC([C@@H1](C)NC(=O)[C@@H1]2CC[C@H1]2N3C=CN=C3)C1 CCC(CC)C(=O)N1C[C@H1](NC(=O)[C@H1]2CCC[C@@H1](C3CC3)O2)CC4=CC=CC=C41 CN1C=C(C(=O)NC[C@H1]2CN(C(=O)C3=CC(N)=C(Cl)C(O)=N3)C[C@H1]2O)N=C1O C#CCC[C@H1](NC(=O)C1=NC=C[NH1]1)C(=O)N2CCCC[C@H1](C)C2 CC1=C(C(=O)NCC2=CC=CC(CNC(=O)[C@@H1](F)CC3CCCC3)=C2)N=CN1C COC(=O)NCC(=O)N[C@H1]1CCN(C(=O)CC2(OC)CCC2)C[C@H1]1CO CCCC1(O)CCN(C(=O)[C@H1](NC(=O)[C@@H1](C)N2C=CN=C2)[C@@H1]3CCOC3)CC1 CC1=CN=CC(C2=CN(C3CCC(NC(=O)C[C@H1]4CCCC4(F)F)CC3)N=N2)=N1 CC1=NC=C(C(=O)N[C@@H1]2CC[C@H1]3CCN(C(=O)[C@@H1](F)C(F)(F)F)[C@H1]2C3)C=N1 C[C@@H1](N=C1[NH1]C2=CC=CC=C2S1)C(=O)NCCCOCCNC(=O)C3(Cl)CC3 CC=C(C)C(=O)NCC1=NC(O)=CC(CNC(=O)C[C@H1]2CN3CCC2CC3)=N1 CS[C@@H1](C(=O)N1C[C@H1](CNC(=O)C2=CN(C(C)C)N=N2)C[C@@H1](C)C1)C(C)(C)C O=C(C=CC1CCCC1)N2C[C@H1]3C[C@@H1](NC(=O)[C@@H1]4CCS4(=O)=O)C[C@H1]2C3 C[C@H1](O)[C@H1](C(=O)N1C[C@@H1]2C[C@H1]1[C@@H1]2NC(=O)C3=CC=CC=C3[N+1](=O)[O-1])N(C)C O=C(NCC12CC(CN1C(=O)CC3=CCCCC3)C2)[C@H1]4CCOC5=CC=CC=C54 C[C@H1](CO)C(=O)N(C)[C@H1]1CCCN(C(=O)CCN2CCOC2=O)CC1 CC1=CC=C(CCC(=O)NC[C@](C)(CO)NC(=O)C2=CC(C(F)F)=CS2)C=N1 CC(=O)NCCNC(=O)CC[C@H1](C)NC(=O)[C@@H1](C)[C@H1]1CCOC1 CCC1=CC(C(=O)N2CCN(C(=O)C[C@H1]3C[C@@H1]3C)[C@H1](CO)C2)=NO1 CCOC(=O)C1(NC(=O)[C@H1]2CCN(C(=O)[C@@H1](O)CC)C23CCC3)CC1 CN(C(=O)OC(C)(C)C)C1CN(C2=NC=CC(=N[C@H1]3C=CCCCC3)[NH1]2)C1 CN1C(=O)C=CN(CC(=O)N2CC[C@@H1](OCCNC(=O)CC3(O)CC3)C2)C1=O CC1=CC=CC(C=CC(=O)N2C[C@H1](C)[C@@H1](NC(=O)C=3C=C(F)N(C)N=3)[C@H1](C)C2)=C1 C#CCCN1CCC(C(=O)N[C@](C)(CNC(=O)C2=CC=C[N+1]([O-1])=C2)C3CC3)CC1 CCCCCC(=O)N[C@H1](CNC(=O)[C@H1]1CCCC2=CC=CN=C21)C3CCC3 CCC1=NOC([C@@H1](C)N2CC[C@@H1](CCNC(=O)C3=CC=C(C(C)C)N=C3C)C2)=N1 O=C(CCC1=CC=C(C(=O)NCC[C@@H1](O)CO)[NH1]1)NCC23CC(F)(CO2)C3 C[C@H1](CNC(=O)CCC1=CC=C(Cl)C(F)=C1)CNC(=O)C2=CC=C3C(=N2)CCO3 CC(C)C1=NOC=C1C(=O)NCCCC[C@H1](C)NC(=O)C(C)(C)S(=O)(=O)C2CC2 CCC(C)(C)[C@H1](OC)C(=O)N1C[C@H1]2[C@@H1](NC(=O)C3=CC=CC(C)=N3)CO[C@H1]2C1 C[C@@H1]1CN(C(=O)C2=CSN=N2)C[C@@H1]1NC(=O)[C@H1]3C[C@](O)(C4=CC=CO4)C3 C#CCCCC(=O)N1CCC2(CC1)CO[C@@H1](CNC(=O)[C@@H1]3CC(C)(C)CCO3)C2 CC1=NC=C(Cl)C(C(=O)N2C[C@@H1]3C[C@H1]2C[C@H1]3CNC(=O)[C@H1]4CCC(=O)C4)=N1 CN=C1[NH1]N=C(CC(=O)N2C[C@](C)(CNC(=O)C[C@H1]3C=CCCC3)CC2(C)C)S1 C[C@@H1](C1=CC=NC=C1)N(C)C(=O)C2=CC=C(CNC(=O)[C@@H1]3COC(=O)N3C)N=C2 CC1(C)C[C@@H1](CC(=O)N2CCCCC23CN(C(=O)C#CC4CCCCC4)C3)CO1 CCO[C@@H1](C)C(=O)N1CC[C@@H1](CNC(=O)C2=C(O)N=NC(C)=C2C)C1 CC1=NOC=C1C(=O)N[C@H1]2CCC[C@H1](NC(=O)C3=CC=C(O)N=C3C)CC2 COC(=O)C1(C)CN(C(=O)[C@@H1]2CC[C@H1](O)CN2C(=O)[C@H1](O)C3=CCCCC3)C1 C#CC1=C[NH1]N=C1C(=O)N[C@@H1](CC)CNC(=O)[C@@H1]2C3=CC=CC=C3OCC2(C)C CC1=CC(N)=C(C(=O)N2CC[C@H1](NC(=O)C3=CN=C(C(F)F)S3)[C@H1](F)C2)C=C1C CC1=NC=C(CC(=O)N2CC=C[C@@H1]2CNC(=O)CSC3=NN=CN3C)S1 O=C(CN1CCC([C@@H1]2C[C@H1]2C3=CC=CC=C3)CC1)NC4=NC=NN4C5CC5 O=C(NCC1=CN=C(C(F)F)S1)C(=O)NC[C@@]23CC[C@@H1](COC2)O3 CC[C@H1]1C[C@@H1]1CNC(=O)[C@@]2(C)CCCN(C(=O)C=3C=NN(C(C)C)N=3)C2 CCOC(=O)C1=NON=C1NC(=O)C2=CC=C(N3C=CN=N3)C=C2 C[C@@H1]1CN(C(=O)C2=CC(=N)[NH1]C(=N)[NH1]2)CC[C@H1]1NC(=O)CSCC3=CC=CC=C3 C=C(C)CN1N=NN=C1[C@H1](NCCC(=O)N2CCC[C@H1](C)C2)C3=NC=C(C)N3C CC1=NC=C(C(=O)N[C@@H1]2CCC[C@@H1](NC3=CC(O)=NC(=O)N3C)C2)C(C(C)C)=N1 CC1=CC=C(C=CC(=O)N[C@H1]2C[C@@](C)(NC(=O)CCCC=3C=CSC=3)C2)S1 CC(C)(C(=O)NCC1CN(C(=O)[C@@]23C[C@H1]4C[C@H1](C(=O)N2)[C@H1]3C4)C1)S(C)(=O)=O O=C(NCCC1=CC=C(Cl)C=C1Cl)C2(C3=CC(F)=CC=C3)CC2 CC1=C[NH1]C(C(=O)N(C)[C@H1](CNC(=O)[C@@H1]2CCCCN2S(C)(=O)=O)C3CC3)=C1C CC1=CC=C(C=CC(=O)N2C[C@@H1]3C[C@]3(NC(=O)C(C)(C)C=4C=NN(C)C=4)C2)C=C1 COC1=CC(C(=O)N(C)CC[C@@H1](C)NC(=O)C2=CC=C(N(C)C)N=N2)=CC(Cl)=N1 COCC=1C=COC=1C(=O)NCCC(C)(C)C(=O)N[C@@H1](C)CC=2C=C(C)[NH1]N=2 CC1=CN(C(C)(C)C(=O)N2CC(O)([C@@H1]3CCCN3C(=O)C4=NNC(=O)C4)C2)C=N1 COCC(F)(F)C(=O)N1C[C@H1](CC(=O)N(C)[C@H1](C)CN(C)C)C2(CC2)C1 CC1(C)C[C@@H1](C(=O)N2CCC(F)(F)[C@@H1](C)C2)CN1C(=O)C3=CN=CC=N3 CC1=C(F)C=CC=C1C2(C(=O)NCCCCN(C)C(=O)[C@H1]3COCC[C@H1]3C)CC2 CCN(C(=O)[C@@H1]1CCC[C@H1](C#N)C1)C2CCN(C(=O)C3=CC(OC)=CN=N3)CC2 CC(C)C1=CC=C(C(=O)NC[C@@H1]2CCC[C@@H1]2NC(=O)[C@H1]3CCC=CO3)S1 CC[C@@H1]1CCCCN1CCN2C(=O)CCN(CC3=CC=C4C(=C3)SCC(=O)N4)C2 CC[C@@H1](CO)N(CC1=CC=CN=C1)CC(C)(C)C CN(C[C@H1]1CN(C(=O)C2=CC=NC(C(F)(F)F)=C2)CCO1)C(=O)[C@@H1]3C=CCCC3 CP(C)(=O)C1=CC=C(C(=O)N2CC[C@H1]3CN(C(=O)C4=NC=NC=C4Cl)C[C@H1]32)N=C1 CC1=CC[C@@H1](C(=O)NC(C)(C)C(=O)N2CCC[C@H1](C(C)C)CC2)CC1 CSCC1(CC(=O)N[C@H1]2C[C@@](C)(NC(=O)[C@@H1]3CC(F)(F)C3(C)C)C2)CC1 CCN1C=CN=C1C(=O)NC[C@H1]2[C@@H1](CNC(=O)CCSC(F)(F)F)C2(F)F COC1(C(F)(F)C(=O)N[C@H1](C)CNC(=O)C(C)(C)C=2C=CN(C)N=2)CCOCC1 CCN(C(=O)C1=CC=C(F)N=C1F)C2CCN(C(=O)[C@@H1]3CSCC(=O)N3)CC2 COCCC1(NC(=O)COCCN(C)C)CCN(C(=O)C2=CC=NC(F)=C2)CC1 CN1N=CC(C(=O)N2C[C@@H1]3CC[C@]3(NC(=O)[C@@H1](F)OC(F)(F)F)C2)=N1 C[C@@H1](CCNC(=O)C[C@H1]1C[C@@H1](NCC=2SC=CC=2Br)C1)NC(=O)OC(C)(C)C CC(=CC(=O)N1CCO[C@@H1]2CN(C(=O)C3=CN=C(S)N=C3)C[C@@H1]21)C(F)F CN(C)C(=O)C(=O)N[C@H1]1COC[C@H1]1C(=O)NCC2(CN=[N+1]=[N-1])CC2 O=C(NCCOC1=CC=CC=C1)N[C@H1]2CCCCCC2=O C[C@H1]1CN(C(=O)C=CC2=CC=C(C(F)F)O2)[C@@H1](C)CN1C(=O)C3=NC=CC=C3Cl CCCC[C@H1](O)[C@H1](C)C(=O)N(C)CCN(C(=O)[C@H1]1C=C(C)CS1)C(C)C CN(C[C@@H1]1CCN(C(=O)C(=O)N=S(C)(C)=O)C1)C(=O)C[C@H1]2CC(C)(C)CO2 COCCOCC1=CC=CC(N2CCC3(CC(CC(=O)OC)C3)C2)=C1 CCN1C=CC(C(=O)NC[C@H1](C)[C@]2(O)CCN(C(=O)C3=C[NH1]C=CC3=N)C2)=N1 C=C(C)CCCC(=O)N1CC[C@@]2(C[C@@H1]2NC(=O)[C@@]34C(=O)[C@H1]5CC[C@H1]3[C@H1]4C5)C1 C[C@H1](CNC(=O)C1=CC=C(Cl)C(O)=C1)NC(=O)[C@H1]2CCC3=CC=CC=C3O2 C[C@@H1](NC(=O)C=1OC=CC=1F)[C@H1]2CCCN2C(=O)CN(C)S(C)(=O)=O COC(=O)C1=CC(NC[C@]23CCCCN2CCC3)=CC(C(=O)OC)=N1 CN(CC(=O)NC[C@H1](CO)NC(=O)C1=NN=C2N1CCCCC2)[C@H1]3CCSC3 N#CCCSCC(=O)N1CC[C@@H1]2[C@H1](C1)CN2C(=O)C3=CSN=N3 CC1=CC(F)=CC(C=C2N3C=NC(C(=O)NCCC=4C=CSC=4)=C3S2)=C1 CCOC1CC(CNC(=O)[C@@H1]2[C@H1](NC(=O)C3=CN=C(OC)S3)C2(C)C)C1 C#CC[C@]1(O)C[C@@H1](C(=O)N2CCC(CCOC)(C(=O)NC[C@H1](O)CN(C)C)CC2)C1 COC(=O)CCCCN1C=C(CNC(=O)C2=CC(Br)=CN3C=CN=C23)N=N1 CC[C@]1(CNC(=O)[C@@H1]2CCO[C@@H1]2CNC(=O)C=3C=C(C)SC=3C)CCC(=O)N1 CC1=NOC(CN(C)C(=O)CC2(N(C)C(=O)CC[C@@H1]3CC3(C)C)CC2)=N1 CC(C)[C@H1]1C[C@H1](C(=O)N(C)CCCOCCNC(=O)C2(O)CCC2)CCO1 CC=1N=NN(CC(=O)N2C[C@H1]3CC[C@@](NC(=O)CC[C@H1](C)C#N)(C3)C2)N=1 NC1=CC(O)=NC(C(=O)N2CCN(C(=O)C34CCN(CC3)CC4)C[C@H1](O)C2)=C1 CCOC1=CC(C(=O)NC2CC(C(=O)N[C@H1]3COC4(CCC4)C3)C2)=CN=C1Br C[C@H1]1C[C@@H1]1C(=O)NC[C@@H1]2CN(C(=O)CCCCN(C)C)CC[C@@]23CCOC3 CN=C1[NH1]C=C(C(=O)N2CCN(C(=O)[C@H1](C)OCC3=CC=CC=C3)CC2)S1 O=C(NCCN1C=CC=CC1=O)[C@H1]2OCC[C@H1]2CNC(=O)C(F)(F)C(F)F CC1=CC=C(N[C@@](C)(C[C@H1](C)C#N)C2=NN=NN2CC3CC3)C=CC1=NNC N=C(O)OCC1=CN(CC(F)(F)CCC(=O)N2CC[C@H1](CC(F)(F)F)C2)N=N1 O=C(N[C@@H1]1C[C@@H1]1CNC(=O)[C@H1]2SCC[C@@H1]2C3=CC=CC=C3)C4CCC(F)(F)CC4 CN(CC(C)(C)CNC(=O)[C@@H1]1CCCC[C@H1]1C(F)(F)F)C(=O)C=CC=2C=CSC=2 C#C[C@H1]1C[C@H1]2CC[C@H1]1N(C(=O)C3(NC(=O)[C@H1](CC(=C)C)OC)CCCC3)C2 CC[C@@](C)(N1C(=O)CCN(C2=CC=C(Br)C=C2C#N)C1=O)C3=NC(C)=NO3 CCC=1C=CSC=1[C@@H1](C(=O)NCCCF)N2CCN3CCCC[C@H1]2C3 CC1=CC(CC(=O)N[C@@H1]2CN(C(=O)C3=CC4=C(Cl)N=CC=C4S3)CC25CC5)=N[NH1]1 C#CC(C)(C)C(=O)NC[C@@]1(F)COCCN(C(=O)CC[C@H1]2CC2(F)F)C1 CCS[C@H1](C)C(=O)N1CCO[C@@H1](CN(C)C(=O)CCC2=NN=C(C)N2C)C1 CCC1=NO[C@@H1](CC(=O)N[C@H1]2CC=C(C(=O)NC3(C)CC4(CCC4)C3)C2)C1 COCC1=CC=CC=C1C(=O)NCC[C@H1]2CCN(C3=NC=NC=4C=CSC3=4)C2 CO[C@H1](C)CCNC(=O)[C@@H1](C)CN(C)C(=O)C1=CC=C(CO)N=C1 O=C(CC1=CC=CO1)N[C@@H1]2CCN(C(=O)C3=C[NH1]C(C4=CC=NC=C4)=N3)C[C@H1]2F O=C([C@@H1](O)CCCC1=CC=CC=C1)N2CCN(C(=O)C3=NOCC3)[C@H1](CCO)C2 CC1=NC=C([N+1](=O)[O-1])C=C1NC(=O)[C@@H1]2CC3=CC=CC=C3CN2C(=O)CSC C[C@H1]1CC[C@@H1](CCC(=O)NC2=CC=CC3=C2C4=CC=CC=C4C3)O1 CC1=NC(C)=C(CN2CC3(C[C@@H1]3C(=O)NC4=NC=NC(Cl)=C4Br)C2)N=C1C O=C(NC1(CNCC2=C(Cl)C=CN=C2Cl)COC1)C3=CC=C4[NH1]N=C(O)C4=C3 C=CCC[C@H1](NC(=O)CC)C(=O)NC[C@H1](CO)C1CC1 CC1=CC=NN1[C@H1](C)C(=O)NCCC[C@@H1](C)NC(=O)C(C)(C)C2=CC=CN=C2F CCC1(C(=O)N2C[C@@H1](O)[C@@H1](CNC(=O)C(C)(C)C(=O)NC)C2)CCC(O)CC1 CC1=CC=CC(C(=O)N2CCC[C@@H1]2C(C)(C)CNC(=O)C=3C=C[NH1]N=3)=C1N CCC1=NOC(C)=C1CNC(=O)C(C)(C)[C@H1]2CCCN2C(=O)CCN3C=CC=C3 COCCNC(=NCCC1=NC(C)=CS1)N2CC[C@H1](C(=O)OC(C)(C)C)C2 C=CC1(C(=O)NC[C@H1]2[C@@H1]3C[C@H1]2CN3C(=O)C4=C[NH1]C=C(C)C4=O)CCC1 COC[C@@H1](C)CC(=O)N(C)CCN(C)C(=O)[C@H1](O)CCC(F)(F)F O=C(CC(F)(F)F)NCC(=O)N[C@H1]1C[C@@H1](NC2=NC=NC3=CC(C4CC4)=NN23)C1 CN(C[C@H1]1CCCN1C(=O)C=CC2CCCCCC2)C(=O)CC(=O)OC(C)(C)C CSC[C@](C)(NC(=O)C=1SC=CC=1C#N)C(=O)NC[C@H1]2CCO[C@H1](C)C2 C=C[C@H1](C)C(=O)N[C@H1]1CCN(C(=O)[C@H1](CC2=CC=CC=C2)N(C)C)C[C@@H1]1O CC1(C)CCC(N)(C(=O)N[C@H1](C2CC2)[C@@H1](O)COCC3=CC=CC=C3F)CC1 C1C(C(=O)NC[C@H1]2[C@@H1]3CN(C(=O)C4=CC=C([N+1](=O)[O-1])C=C4N)C[C@H1]23)C(F)C1 C#CCCCCCC(=O)N[C@@H1]1CCN(C(=O)CC2(C(F)(F)F)CCC2)C[C@@H1]1O CC1=CC=CC=C1CCC(=O)NC[C@H1](CO)CNC(=O)[C@@H1]2CCOC2=O CS(=O)(=O)N1CC[C@H1](C(=O)N2CC[C@](O)(CNC(=O)C3=CC=C(F)S3)C2)C1 C#CC1(C(=O)N2C[C@H1]3CC[C@H1]2[C@H1](NC(=O)CC4=CC=NS4)C3)CCC1 CN(C)CC1=CC=C(C(=O)N[C@@H1]2CN(C(=O)CCC(C)(F)F)C(C)(C)C2)[NH1]1 COCCCC(=O)N1CC[C@H1]2CCN(C(=O)C=3[NH1]C(C)=C([N+1](=O)[O-1])C=3C)C[C@H1]21 CCCN(C(=O)C(Br)=C(C)C)[C@H1]1CCN(C(=O)[C@H1]2CCC(=O)C2)C1 COC(=O)[C@@H1]1C=CCCN1C(=O)[C@@H1]2CCN(C(=O)CCC[C@H1]3C[C@H1]3C)CC2(C)C CCOC1=NC=CC=C1C(=O)N2C[C@H1]3C[C@H1]2CN3C(=O)C4=C[NH1]C5=NC=CC5=C4 C=C[C@H1]1CN(C(=O)C[C@H1]2CCC[C@@H1](NC(=O)[C@H1](C#N)CC)C2)C[C@H1]1O CCC1=CC(N[C@@H1]2CN(C(=O)[C@H1](F)CC3CCCC3)CC24CCC4)=NC(CC)=N1 CC(C(=O)N1CCC(CCN(C)C(=O)[C@@]2(C)C[C@H1]2F)CC1)=C3CCC3 CO[C@@]1(CNC(=O)CC(F)(F)F)CCN(C(=O)[C@]2(C)CC(C)=NO2)C1 CCN(C)C1=NC(N(C)CC2=CC=C(C(C)(C)C)C=C2)=NC3=C1C[C@@H1](C)CC3 CC(=O)N1CCOC[C@@H1]1C(=O)N[C@@H1]2CCN(C(=O)C3=CC=C4[NH1]N=C(O)C4=C3)C2 COC(=O)[C@H1](CCF)NC(=O)[C@@H1](NC(=O)C1=C[NH1]C(=S)C=N1)C2=CC=CN=C2 C=CCSCC(=O)NC[C@]1(F)C[C@H1](NC(=O)CN2C(=O)C=NC3=CC=CC=C32)C1 CCN1C=C(C(=O)NCC#CCNC(=O)C=2C=NN(C)C=2Cl)C(C3CC3)=N1 O=C(CC1=CC(Cl)=CS1)NCC[C@]23CC[C@H1]2CN(C(=O)CN4C=NN=C4O)C3 CCOCCC1(C(=O)N2CC[C@H1]3[C@@H1](CC2)[C@@H1]3NC(=O)C4=CC=NC=C4F)CCC1 C[C@H1](NC(=NCCCOC1CCCC1)NC2CC2)C3=CC=NC=C3Cl CS[C@@H1](C)CC(=O)N1CCC[C@H1]1CN(C)C(=O)C2(N3C=CC=C3)CCCC2 CC(C)C[C@@H1](C(=O)N[C@H1](C)CNC(=O)C1=CC(Cl)=C(F)C=C1O)N(C)C CCC1(C(=O)NCCC[C@@H1](C)NC(=O)C2=NN(C)C=C2S(C)(=O)=O)CCC1 C[C@@H1](C[C@@H1](C)NC(=O)C1=CC=CC(F)=C1F)NC(=O)[C@@]23CCCN(CC2)C3 CC[C@H1](C)C1=CC=CC=C1OCC(=O)N[C@@H1]2CC23CCC(NC(=O)CCF)CC3 COC[C@]1(C(=O)NC[C@H1]2C[C@]3(CCN(C(=O)C(C)(C)C)C3)CO2)CCCO1 CC1=CN=C(C)C(NC(=O)[C@H1]2COCCN(CC3=CC(Cl)=C(F)C(Cl)=C3)C2)=C1 CO[C@@H1](C)C(=O)N1CC[C@H1](OCCNC(=O)C2=CN(C)C3=CC=C(F)C=C23)C1 O=C(NC[C@]12CC[C@H1]1CCN2C(=O)C3=CC=C([N+1](=O)[O-1])C=C3)C4=CCCCO4 NC1=CC(C(=O)N2CCN(C(=O)C=3[NH1]N=C([N+1](=O)[O-1])C=3Cl)[C@H1](CO)C2)=NC=C1Cl C=CCN(CCC(=O)NCCC[C@@H1]1CCC[C@H1]1O)C(=O)C2=CC=NC=N2 CC(C)(C)/C=C/CC(=O)NC[C@@H1]1C[C@@H1]2C[C@@H1]2N1C(=O)C#C[C@H1]3CCCO3 CC1=CC(C(=O)N[C@@H1]2CC[C@](F)(CNC(=O)C3=CC=C(O)C=N3)C2)=NO1 CO[C@](C)(CC1CCC1)C(=O)N2C[C@H1](O)[C@H1](NC(=O)CCN3C=CC=N3)C2 CCC[C@@H1](C)N1N=CC=C1NC(=O)C2=CC(Br)=C(C3CC3)S2 CS(=O)(=O)NCCN=C1C=CN=C(N[C@@H1](CO)C2CC3=CC=CC=C3C2)[NH1]1 CCC=1C=CSC=1[C@@H1](C(=O)NCC(C)C)N2CCS(=O)(=O)[C@H1](CO)C2 CC=CC=CC(=O)N[C@@H1]1C[C@H1]2CN(C(=O)C3=CC=C(C=4C=NN(C)C=4)O3)C[C@@H1]21 CC[C@]1(NC(=O)COC2=CC=CN=C2)CCCN(C(=O)[C@H1](C)N3N=CC=C3C)C1 CC1(C)CO[C@H1](CC(=O)N[C@@H1]2CCC[C@@H1]2NC(=O)C=3SC4=NC=CC=C4C=3N)C1 CN(C(=O)C1=CSC2=CC=CC=C12)[C@@H1]3CN(C(=O)[C@H1]4CC45CCCCC5)C[C@H1]3O CO[C@@H1][C@@H1](NC(=O)C1=COC(CNC(=O)C2(OC)CC(C)(C)C2)=N1)CC(C)C C[C@H1]1CCC[C@@H1](C)N1C(=O)[C@H1]2C[C@H1](F)CN(C3=CC4=NC=NN4C=N3)C2 COCC(C)(C)C(=O)NC[C@@H1]1N(C(=O)CC#N)CCC1(C)C CN(C[C@@H1]1CCOC1)C(=O)C[C@@]2(C)CCN2C(=O)C3=CC=NS3 COC(=O)CC[C@H1](NC(=O)[C@H1](C1=CC=NC(F)=C1)N2CCC2)C(=O)OC CC[C@@H1]1CN(CC2=CC=C(OC)C=N2)CCN1C(=O)C3=NC4=CC=CC=C4[NH1]3 C=C1C[C@@H1]1C(=O)N[C@@H1]2CN(C(=O)C3CCN(C(=O)OCC)CC3)C[C@H1]2C4CC4 CCC(CC)N[C@H1](C1=CC(Br)=C(OC)N=C1C)C2=NN=NN2CCC3CC3 CC[C@H1]1CN(C(=O)[C@@H1]2CCCN2C(C)C)C[C@@H1]1C(=O)N[C@@H1](C)C3=CC=C(C)C=N3 C#CCO[C@H1](C)C(=O)NCC[C@@H1]1CCN(C(=O)CC2=CC=CC(C)=C2Cl)C1 CCC1=CC=C(C(=O)N[C@@H1]2CCCN(C(=O)[C@@H1]3C[C@H1]3C)[C@H1]2C)C(F)=C1 C=CCNC(=O)[C@@H1]([C@@H1](C)CCC)N1CCN(C)CCN(C)CC1 C[C@@H1](C(=O)N(C)CCN1CCN(C(=O)CC(C)(C)F)CC1)C2=C(Cl)C=CC=C2Cl COC1=CC=CC(/C=C/C(=O)N2CC[C@@H1](NC(=O)C3=CC=C(F)N=C3)[C@H1](F)C2)=C1 CC=1[NH1]N=C(C(=O)N2CCCC[C@H1]2[C@H1](C)NC(=O)C(C)(C)C3=CN=CO3)C=1Cl CC[C@@H1](C(=O)NCC1=CC=CC(N2C=C(C3(O)CC3)N=N2)=C1)C4=CC=C(F)C=C4 CCN1N=C(C)C(C(=O)NC2=CC=CC(NC(=O)[C@H1]3CCC(F)(F)CO3)=C2)=C1C C=CCC(=O)NC[C@H1](NC(=O)C1=NN(C2=CC=CC=C2)N=C1C)[C@H1]3CCOC3 CC1=CC(F)=CC=C1[C@H1](O)C(=O)N[C@H1]2CCN(C(=O)CC3=NN=CN3C)C[C@@H1]2O CC1=CC=C(C(=O)N2C[C@@H1]3C[C@]3(NC(=O)C4(C(F)(F)F)CC(C)(C)C4)C2)C(O)=C1 C[C@H1]1CC[C@H1]1C(=O)NC2=CC=C(F)C(C(F)(F)F)=C2 O=C(NC[C@H1]1COCCN1C(=O)[C@@H1]2CCCC23CC3)C4=CCS(=O)(=O)C4 COC(=O)C=1C=NN(CCNC(=O)C2=CC=CN=C2OC3=CC=CC=C3)C=1 COCC=CC(=O)N[C@@H1]1[C@H1](C)CCN(C(=O)CC2=CC=C(C)O2)[C@@H1]1C C=C[C@H1]1C[C@@]1(CO)CNC(=O)[C@@H1](C)N(CC)C(=O)[C@@H1](CC)NC(N)=O CC1=CC=CN=C1CNC(=O)[C@@H1]2CCN(C(=O)CCN3CCCCC3)C24CCC4 C=C[C@]1(C)COCCN1C(=O)C2=CC=NN=C2NC3CC3 CN1C=C(C(=O)NC[C@H1]2O[C@H1](CO)[C@H1]2)C(Cl)=N1 C[C@@H1](O)CCCCCC(=O)N1CC[C@@H1](NC(=O)C2=CC([N+1](=O)[O-1])=C(Cl)C=C2Cl)C1 O=C(C1=C(Cl)C=CN=C1Cl)N2CC[C@@]3(CCN(C(=O)C4=CC=C(Cl)N=C4)C3)C2 C[C@H1](C(=O)N1CC2[C@H1]CC[C@H1](NC(=O)C[C@H1]3C[C@@H1](O)C3(C)C)[C@H1]1C2)C4=CC=CS4 CCC1(CC)C[C@H1](NC(=O)[C@H1]2C[C@@H1]3CC[C@@H1]3C2)CN1C(=O)CC4=NC=CN4C CC(=O)OC1CCN(C(=O)/C=C/C(C)(C)NC(=O)C[C@@H1]2CCCC[C@H1]2C)CC1 CC1=CC=NC(C(=O)N[C@H1](C)C[C@H1](C)NC(=O)C#C[C@@H1]2CCOC2)=C1 CNC1=CC=CC(C(=O)N[C@H1]2C[C@@H1](F)CN(C(=O)C3=CC=CC(C(N)=O)=C3F)C2)=N1 CC1=CC(C(=O)NC[C@@H1]2C[C@H1]3CN(C(=O)C=4SC=CC=4CC#N)C[C@@H1]23)=NS1 CC(C)(C)CC(=O)N1CCC[C@@](O)(CNC(=O)C2(CC3=CC=CC(F)=C3)CC2)C1 CN1C=C(C(=O)NC[C@H1]2C[C@@H1]2NC(=O)C3CCOCC3)C(C4=CC=CC=N4)=N1 C[C@@H1]1CCN(C(=O)C2CCC2)[C@H1]1CNC(=O)[C@@H1]3CCCC4=NN=CN43 CCC(CC)[C@@H1](C(=O)NCCCC1CC1)N2CC[C@@H1](C3=CC=C(C(C)C)C=C3)C2 C=C[C@H1](CC)C(=O)N[C@@H1]1C[C@H1]2CC[C@H1]1CN2C(=O)CCCCC#N CC1=CN=C(C2=NC(CCC(C)C)=NN2C3=CC=CN=C3)C=N1 CC1=CC=C2OC(C(=O)N3CCC[C@@]3(C)CNC(=O)CC4=CC=NS4)=C(C)C2=C1 C[C@]1(C(=O)N2CCN(C(=O)C3CC(=O)C3)[C@@H1](CCO)C2)C=CCCC1 C=C[C@H1](OC)C(=O)N1[C@H1]2CC[C@H1]1CC(C[C@@H1](C)NC(=O)CCC3=CON=C3C)C2 C[C@H1](C(=O)N[C@@H1](C(=O)NCCCC=1N=CN(C)N=1)C2=CC=CS2)N3C=CN=N3 CN1CCC[C@H1]1C=CC(=O)N2C[C@H1](C(=O)NC3=CN=C(O)C(F)=C3)CCC2(C)C CC(C)(CCCNC(=O)CS[C@H1]1CCOC1=O)NC(=O)C[C@H1]2CCCOCC2 C[C@H1]1CC[C@@H1](CCC(=O)NCC=2OC=CC=2C(=O)NCC3CC(=C4CCC4)C3)O1 O=C([C@@H1](O)C(F)F)N1CCCC[C@H1](NC(=O)C2(C(=O)NC3CC3)CC2)C1 CCCC[C@@H1](O)CC(=O)NC(C)(C)[C@H1](C)CC(=O)N1CCC([C@@H1](C)OC)CC1 C=CCCOCCCCC(=O)N[C@H1]1C[C@@H1]2CN(C(=O)CN3C=C(Cl)C=N3)C[C@@H1]2C1 CC[C@H1](CC(=O)N[C@@]1(C(=O)N[C@@H1](CCO)CN(C)C)CCC(C)(C)C1C)N(C)C COC1(CC(=O)NC[C@H1](CC(C)C)C(=O)N(CC(F)F)C[C@H1](C)O)CCC1 NS(=O)(=O)C1=C(NC(=O)NC2=NC(C3=CC=CC=N3)=CS2)C=C(Br)C=C1[N+1](=O)[O-1] C[C@@](O)(C(=O)N[C@@H1]1C[C@@H1]1CNC(=O)C2=CN=C(COC3=CC=CC=C3)S2)C4CC4 CC(C)C=1SC=NC=1C(=O)N[C@H1]2CCN(C(=O)CS(=O)(=O)N(C)C)[C@H1](C)C2 CC[C@H1](C)CC(=O)N(CC)[C@H1](C)CNC(=O)C1=CC=C(NC(=O)NC)C=C1 CC1=CC(C(=O)N[C@@H1]2CS(=O)(=O)C[C@@H1]2NC(=O)C=3[NH1]C=NC=3C#N)=CC(C)=C1C CCN1N=NC=C1C(=O)NCC2=CC(C(=O)N3CC4(CC[C@H1]4O)C3)=CS2 COC1=NC=C(C(=O)N(CCO)[C@H1]2CCCN(C(=O)C=3SC(OC)=NC=3C)C2)S1 CCOCC1=NC(C)=C(C(=O)N(C)C2CN(C(=O)[C@H1]3CCC=CCCC3)C2)S1 CC1=NC=NC=C1NC(=O)C[C@@H1]2CN(C(=O)CN3N=CN(C)C3=O)CCO2 NC1=C(C(=O)N2CC(OC(F)F)C2)C=NN1CC(F)(F)F C=C(C)CC(=O)N1CCC[C@@](O)(CCNC(=O)[C@@H1]2CCSC3=CC=CC=C32)C1 CS(=O)(=O)CC1=CN(CC(F)(F)CCC(=O)NCCN2CCN3N=CC=C32)N=N1 C[C@@H1](CNC(=O)C1=CC=CC(Cl)=C1N)NC(=O)C2=CN(C)C(C3=CC=CC=N3)=N2 C=CCC1(NC(=O)C2=C[NH1]N=C2C)CN(C(=O)C(=O)N3CCC(C)CC3)C1 CC=1C=C(C)N(CC(=O)N[C@@H1]2COCCN(C(=O)/C=C/C(F)(F)F)C2)N=1 CCS(=O)(=O)C1=NC=CC(=N[C@H1](C)CN(C)C(=O)[C@H1](C)OCCN(C)C)[NH1]1 CCO[C@H1]1C[C@@H1]1C(=O)N2CC[C@H1](C)N(C(=O)C=CC3=CC=C4C(=C3)CCO4)CC2 CC(C)CO[C@H1](C(=O)N1CC=C[C@@H1]1CNC(=O)CN2CC[C@@H1](C)C2)C(C)C CSC1=CC=C(CCCC(=O)N2C[C@H1]3[C@H1](NC(=O)C4=CC(=O)N(C)O4)[C@H1]3C2)C=C1 CCC[C@H1](O)C(=O)N1CC2(NC(=O)C3=CC(C(=O)OC)=NC=C3F)CCC1CC2 CO[C@@H1](C)CC(=O)N[C@@](C)(CNC(=O)C1=CC(C2=CC=CC=C2)=NO1)C(C)C CC(C)(F)CCC(=O)N[C@@H1]1CC[C@H1](CNC(=O)[C@@H1]2C[C@]23CCC4=CC=CC=C43)C1 CC=CC=CC(=O)N[C@@H1](CNC(=O)C1=CN=CC=C1N(C)C)[C@H1]2CCOC2 CC(C)OC(=O)C[C@@H1](NC(=O)N1CCCCC[C@@H1]1CO)C2=CC=CC=C2 CCCN(CCNC(=O)C[C@@H1](C1=CC=CC=C1)C(C)C)C(=O)[C@H1](C)CC(C)(C)C CCCCCC(=O)N1[C@H1](CNC(=O)C2=CC=CN3C(C)=NN=C23)C[C@@H1]4CCC[C@@H1]41 CCN1CC[C@@H1](C(=O)NC2=CN=C(OC)C=C2C(=O)N3CC(F)(F)C(F)(F)C3)C1 CO[C@H1]1CN(C(=O)C2=CC=CC(F)=C2)[C@](C)(CNC(=O)COC(F)F)C1 CC1=COC=C1C(=O)N[C@H1](CCC(=O)NCC[C@H1]2CCC[C@@H1](C)C2)C(C)C CSC1=CC=CC(CC(=O)NCCC2(NC(=O)C[C@@H1](C)N3C=CC=C3)CC2)=C1 COC1=CC=C(CCCCCC(=O)NC=CC2=CC=NC=N2)C=C1 CCOC(=O)C[C@@H1](C)C(=O)N1CCCC[C@H1](C(=O)N2CCC(F)(F)C[C@H1]2C)C1 COC(=O)C1=CC=CC(C(=O)NC[C@@H1]2CN(C(=O)C3=C[NH1]N=C3F)C[C@H1]2CF)=N1 C[C@]1(CN=C2[NH1]C3=C(C(=NCCN4CCC4)[NH1]2)CCCCC3)C=CCCC1 COC1(CS(=O)(=O)NCC2=CC=C3C=C(C)C=CC3=N2)CCOCC1 CC(=O)CCCCC(=O)N1[C@@H1](C(=O)N(C)C2(C)CCCC2)CCC13CC3 COC1=CC=C(OC)C(C(=O)N2C[C@H1](C)[C@@H1](NS(=O)(=O)C3CC3)C2)=C1OC CCC1=NC(C(=O)N2CCN(C(=O)[C@H1](C)COC)[C@H1](C(C)C)C2)=CO1 CCC(CC)(CNC(=O)CN1CCCNS1(=O)=O)NC(=O)C2=C[NH1]C=C(Cl)C2=O CCN(C)CC(=O)N[C@H1]1C[C@H1]2CC[C@H1]1CN2C(=O)C3(OC)CCOCC3 CCC[C@@H1](O)C(=O)N(C)CC(C)(C)CNC(=O)[C@@H1]1CCN(S(C)(=O)=O)C1 CCC[C@H1](OCC)C(=O)N1C[C@H1](CC)[C@@H1](C(=O)N2CC[C@H1](C3(C)CC3)C2)C1 CC[C@]1(C)C=C(C(=O)NC2CC(O)(CNC(=O)C3CN(C(C)=O)C3)C2)C1 CO[C@]1(CNC(=O)[C@H1](F)[C@H1]2CCN(C(=O)CC3=N[NH1]C(C)=N3)C2)CC[C@H1](C)C1 CC1=NC=C(CC(=O)NCC=2N=COC=2C3CN(C(=O)[C@@H1]4NC(=O)C[C@H1]4C)C3)O1 CCOC(=O)CCC(=O)N1CCC(N(C[C@H1]2CCCO2)C(=O)C=CSC)CC1 C=C1[C@H1](C(=O)OC)[C@H1]1C(=O)N2CCN(C(=O)[C@]3(C)CCCN3C)C[C@@H1]2C4CC4 C[C@@H1](F)CC(=O)NCCCC[C@@H1](CO)NC(=O)CCS(=O)(=O)N(C)C COC[C@H1](C)N1CC[C@H1](NC(=O)C2=CC=NC(C)=C2)[C@H1](O)C1 C[C@@H1](C(=O)N1C[C@@H1]2C[C@H1](C1)C2NC(=O)[C@H1]3CCCCS3)N4CCCC4 O=C1CC[C@H1](C(=O)NC[C@@]2(O)CCCN(CC3=CC(F)=CC=C3I)CC2)CN1 CC1=CC=CC(C(C)C)=C1C(=O)NCCCN(C)C(=O)[C@H1]2C(F)(F)C23CC3 CCC[C@H1](OC1=CC=C(Cl)C=C1C)C(=O)NC2=CC=CC(CO)=C2 CCCC(=O)NCC(C)(C)CC(=O)N(CC)CC(F)F C[C@](O)(CNC(=O)[C@]12CCC[C@H1]1CCN2C(=O)[C@@H1]3[C@@H1]4CC[C@H1](F)[C@H1]43)C(F)F O=C(CC1=CC=C(F)C=C1)NC[C@H1]2C[C@@H1](C(=O)NCCOC3=NC=CC=N3)CO2 COCCCC(=O)N1C[C@@H1](O)[C@H1](N(C)C(=O)C=2C=C(CCCO)ON=2)C1 CC1(C)C[C@H1]1C(=O)N[C@@H1]2CC[C@@H1](NC(=O)C3=CC=C(Br)C(F)=C3)C2 COC(=O)[C@H1]1C[C@@H1](C(=O)N2CCOC[C@H1]2CCNC(=O)[C@@H1]3C[C@@H1](F)C(=O)N3)C1 CC=CCC(=O)N[C@H1]1COC2(C1)CN(C(=O)C[C@@H1]3CCN(C)C3)C2 O=C(NC[C@H1]1COCCN1C(=O)C2CC(F)C2)C3=CN=C(O)C=4C=CSC3=4 CO[C@H1](C)CC(=O)N(C)CCCOCCNC(=O)C1=CC2=C(N=C1O)CCOC2 CCN1N=NC(C(=O)N[C@](C)(CO)C(=O)NCCCOC)=C1C CC(C)(O)CN1C=C(C2=CC=CN=C2C(=O)NC3=CC(F)=C(Br)C(Cl)=C3)C=N1 COCC=1C=C(C(=O)NC[C@H1](C2CC2)N(C)C(=O)/C=C/[C@H1]3CCCO3)N(C)C=1 CSC[C@H1](C(=O)N1CC(NC(=O)[C@@H1](C)C2=CC=C(N(C)C)C=C2)C1)C3=CC=CC=C3 CCCN(C(=O)C[C@H1](C)CC(F)(F)F)[C@H1]1CCN(C(=O)CCOCCCOC)C1 CCC[C@H1](NC(=O)[C@H1](F)OC(F)(F)F)C(=O)N1CC[C@H1]2CN(C)C[C@@H1]2C1 CSC1=NC=CN=C1C(=O)N[C@H1](C)C[C@@H1](C)NC(=O)C2=C(C(F)(F)F)C=NN2C CSCC1(CC(=O)N[C@H1]2C[C@H1]2NC(=O)C[C@@H1]3CCC(C)(C)O3)CC1 COCCO[C@@H1](C)C(=O)N[C@@H1]1CN(C(=O)C2=CC(F)=C[NH1]2)C[C@H1]1C=3C=NN(C)C=3 CO[C@@H1]1C[C@@H1](CNC(=O)C(F)(F)[C@H1](C)O)N(C(=O)C2=N[NH1]C=C2C)C1 CCOCCCC(=O)NCCN(C(=O)CC1=CN(CC)N=C1C)C2CC2 CCC=1N=C(C)OC=1C(=O)N[C@@]2(C(=O)NCCN(CC)C(C)C)CCC(C)(C)C2 CN(C[C@H1](O)CNC(=O)[C@@H1]1CC(=O)[C@H1]1C)C(=O)[C@H1]2CC[C@H1](F)C2 CC1=CC=C(OCCC(=O)N2C[C@@H1]3[C@@H1](C2)N3C(=O)CC4=CC(F)=C(F)C=C4Br)C=C1 C=CCCC(C)(C)NC(=O)[C@H1](C(C)C)[C@H1](C)NC(=O)C1CC(=C2CCC2)C1 CCOC1=CC=C(C(=O)N2C[C@H1](C(=O)NC3=CC=C(C)C=N3)CC(F)(F)C2)N=N1 COC(=O)[C@](C)(O)CNC(=O)[C@@H1]1CN(C(=O)[C@@]2(C)C=CCCC2)CC13CCC3 CC1=CC(O)=C(C(=O)N(C)CCN(C)C(=O)C2=CSC(C)=N2)C=C1Br COC1=NC(C)=C(C(=O)N2CC=C[C@H1]2CNC(=O)C(C)(C)C=3C=CN(C)N=3)S1 CCN(C)[C@]1(C)CCN(C(=O)C[C@@H1](NC(=O)[C@H1]2C[C@H1](SC)C2)C(F)(F)F)C1 O=C(N[C@H1]1C[C@@H1]2CC[C@H1](C1)N2C(=O)COCC3=CC=NC=C3)C4=CN=C(O)S4 CCC(CC)C(=O)N1CCO[C@@H1](CN(C)C(=O)C[C@H1](C)C2CCCC2)C1 C=CN1N=NC=C1C(=O)N[C@H1]2CCN(C(=O)C3C[C@@H1]4CC[C@H1](C3)O4)[C@@H1]2CC CC[C@@H1](C)CC[C@H1](O)CC(=O)N1CC(O)(CN=C2C=CN=C(CO)[NH1]2)C1 O=C(N[C@@H1]1CC[C@H1](NC(=O)C2=COC(Cl)=C2)C1)C3=COC(C(F)F)=N3 CC1=CC(F)=CC(C(=O)NC[C@@H1]2C[C@@H1](CNC(=O)CCCC3CCC3)CO2)=C1N C[C@@H1]1CCN(C(=O)CCN2CCOCC2)[C@H1](CNC(=O)[C@H1]3CCCC[C@H1]3C)C1 C=C[C@H1](O)C(=O)N1CC[C@@]2(CC[C@H1](NC(=O)C3=NC=NC(C)=C3C)C2)C1 CC(C)CCC(=O)N(CCNC(=O)CCCCCC#N)C1CCCC1 CC[C@H1](C)CCCCC(=O)NC1(CC(=O)NC2=CC=C(O)C=C2C)CCCCC1 C=C1CCN(C(=O)CCC2=CN=CS2)[C@H1](C(=O)N[C@H1]3CCN4C=NN=C4C3)C1 CC1=NSC(C)=C1C(=O)N[C@@]2(C)CCN(C(=O)[C@@H1]3C[C@@H1]4CCCC[C@@H1]43)C2 CCCSCC(=O)N[C@@H1](CC1=CN=C[NH1]1)C(=O)N2[C@H1]3CC[C@H1]2COC3 C[C@H1](NC(=O)[C@H1](C)CO)[C@@H1]1CCN(C(=O)COCC2=CC=CC=N2)C1 C[C@@H1]1CC[C@@H1](NC(=O)C2(C)CC3(CC3)C2)CN1C(=O)C[C@@H1]4CCC(=O)N4C C[C@H1](NC(=O)C1(O)CCCCC1)[C@@H1](C)C(=O)NC2CC2 CC[C@@H1](C(=O)N[C@H1]1CCCCC[C@@H1]1NC(=O)C[C@H1]2CNC(=O)O2)N3N=CC=C3C CO[C@@H1]1CCC12CC(C(=O)NC3CC[C@](O)(CCNC(=O)CCCCC#N)C3)C2 O=C(CN1C[C@H1]2C=C[C@H1]1C2)NCC3(O)CN(C(=O)C4=N[NH1]C=C4Br)C3 CC[C@H1](C)C(=O)N1C[C@H1](F)[C@H1](NC(=O)C2=CCCC2(C)C)C1 CC[C@@H1]1CCCC[C@@H1]1C(=O)N2CCC(N(C)C(=O)C=3C=NN(C)C=3COC)CC2 CC=C[C@H1](O)C(=O)N[C@@H1](CNC(=O)C(C)(C)F)C1=CC=C(F)C=C1F C[S@](=O)CC[C@H1](O)C(=O)N1C[C@@H1]2CC[C@H1](C1)N2C(=O)C=3C=NN(CCO)C=3 CSC1CC(N(C)C(=O)[C@H1](NC(=O)C=2C=CON=2)C3=CC=NN3C)C1 CCCN(C)CC(=O)N1CC[C@@H1](CNC(=O)CCN(C)CCCCOC)C1 CCC12CN(C(=O)CCOC3COC3)C(CNC(=O)[C@@](C)(CC)OC)(C1)C2 C=C1CC(C)(C(=O)N2CCOC3(CCS(=O)(=NC(=O)C4=CC=CN=N4)CC3)C2)C1 CO[C@@H1](C(=O)N1CCC(C(C)(C)NC(=O)C2C(C)(C)C2(C)C)CC1)C3CCC3 CC=1OC(C2=CC=C(F)C=C2)=NC=1COC(=O)C3=CC=CC(N4C=CN=C4)=C3 COCC1(NC(=O)[C@H1]2COCC[C@H1]2C)CN(C(=O)/C=C/CN3CCCCC3)C1 O=C(NC[C@H1]1C[C@@H1](NC(=O)[C@@]23CSC[C@@H1]2C3)C1)[C@H1](F)C4=CC=CC=C4F CCC[C@@H1](NC(C)=O)C(=O)N1CCCC[C@H1](CNC(=O)C2=CC=C(C)C(F)=C2)C1 COC(=O)C1=CC=CC=C1NC(=O)[C@H1]2CN(C(=O)CCN3C=NC=N3)CC[C@@H1]2O CC1=CN=C(C(=O)N2CCC3(CC3)C[C@@H1]2C(=O)N[C@H1]4CCOC[C@H1]4F)C=[N+1]1[O-1] CC(C)(CCNC(=O)C1CC2(CCOC2)C1)NC(=O)C3=CC(Cl)=C(Cl)C=C3N C=C(C)CN1N=NN=C1[C@@H1](CC[C@@H1]2CC=CCC2)NCCC3=COC=N3 CC1=C(C(=O)N(C)C[C@@H1]2CCCN(C(=O)[C@H1]3C[C@H1](O)C3)C2)[NH1]C4=C(Cl)C=CC=C14 CC(C)N(CCNC(=O)COCC=1N=C[NH1]N=1)C(=O)C2=CC(C(C)(C)C)=NO2 C#CC(C)(C)C(=O)NCC[C@H1]1C[C@H1](NC(=O)[C@@H1]2CCCN2CCC(C)C)C1 N#CC1=CC(S(=O)(=O)NC[C@@H1](O)CO)=CC=C1N[C@@H1]2CCC3=CN=CN3C2 CCCCC[C@H1](O)CC(=O)N[C@@H1]1CC[C@H1]1NC(=O)C2=CC=CC(S(=O)(=O)NC)=C2 O=C(NCC1=CC(Cl)=CC=C1F)C(=O)N2CCC3=C(C=C(C4CC4)N=N3)C2 CC1(C)CCO[C@@H1]1CNC(=O)C[C@H1]2C[C@H1](NC(=O)C=3[NH1]C=CC=3C4CC4)C2 C=C(Cl)C(C)(C)C(=O)N[C@H1](CC)CNC(=O)C1=CN=C(SC)[NH1]1 COC=1C=CSC=1C(=O)N2CC3(CC[C@@H1]3NC(=O)CC=4C(C)=NOC=4C)C2 CN(C)C[C@@H1](NC(=O)[C@@H1]1CCCOCC1)C(=O)N(C)CC=2C=N[NH1]C=2 CCN1N=CC(Cl)=C1C(=O)N[C@H1]2CCN(C(=O)C3=CC=CC4=C[NH1]N=C34)C[C@@H1]2C C=C[C@@H1](C)CC(=O)NCC(C)(C)C#CC(=O)NC[C@H1](O)CCOC C[S@](=O)CCC(=O)NC1CC2(CCN(C(=O)C3=NC=C(C4CC4)C=C3F)C2)C1 C=CC(C)(C)C(=O)N1CC[C@H1](CO)[C@@H1](NC(=O)[C@@H1](C)CC)CC1 C#CCN(CC(=O)NCC#CCO)C(=O)C1=C(C)OCC1 CC1=CC(C(=O)NC2=CC=C(NC(=O)[C@H1](CO)NC(N)=O)C=C2C)=C(C)N=C1C C=CC[C@@]1(C(=O)N2CC[C@H1](NC(=O)C(C)(C)C)C[C@H1](O)C2)CCOC1 C=CCC1(NC(=O)C(=O)NC(C)C)CN(C(=O)C[C@@H1]2C[C@H1]2C(F)(F)F)C1 CSC1=CC(C(=O)NCCCC(C)(C)C(=O)NCCC2=CC=C(C)S2)=CO1 CSCC[C@@H1](O)C(=O)N(C)C[C@H1]1CCCN(C2=NC=CC=C2S(C)(=O)=O)C1 COC1=CC=CC(C[S@@](=O)[C@@H1](C)C(=O)NN=C=C(C)C2=NC=CN2C)=N1 CC1=CC=CC(C(=O)N2CC[C@@H1](CNC(=O)C3=CC=CC4=C3COC4)C2)=C1F C=CCCC(=O)N[C@H1]1CC[C@H1](CNC(=O)C2=CN=C(C3=NC=CC=N3)S2)C1 O=C(C1=CC=C(O)C(F)=C1)N2CCC[C@@H1](NC(=O)CCCC3=CC=C(Br)C=C3)C2 N#CC=1SC=CC=1NC(=O)[C@@H1]2C=C[C@H1](NC(=O)[C@H1]3C[C@H1]3C4=CC=C(F)C=C4)C2 C[C@H1]1CN(C(=O)[C@H1](CC(N)=O)NC(=O)[C@H1](C)C2(O)CCC2)CC(C)(C)O1 O=C(N[C@H1]1CC[C@]2(CCCN(C(=O)C3=CN4C(=N3)CCCC4)C2)C1)C5=CN=NS5 N=C1[NH1]C(C(=O)NC2CN(C(=O)CC3=C[NH1]C4=CC(Br)=CC=C34)C2)=CS1 O=C(NC1=CC=CC2=C1OCC2)[C@@H1]3CC4(CCN3C(=O)C5=CN=CN=C5)CC4 C[C@@H1]1C[C@H1]1C(=O)NCCC(=O)NC[C@H1]2C[C@H1](NC(=O)C3=CN=C(C(F)F)N=C3)C2 CCC1(C(=O)NC[C@@H1](C)C2CCN(C(=O)C3=CN=C(N)C=N3)CC2)COC1 CC[C@@H1]1C[C@@H1]1C(=O)N2CC[C@@H1]3CCN(C(=O)C(C#N)=COCC)C[C@@H1]3C2 O=C(CN1N=NC(C2CC2)=N1)N3CCN4C(=CC5=C(Cl)C=CC=C54)C3 C[C@H1](NC(=O)C1=CC([N+1](=O)[O-1])=CC=C1N(C)C)C2CN(C(=O)C3(CCF)CC3)C2 CC[C@@H1](C#N)C(=O)N1CCC[C@H1](CN(C)C(=O)[C@H1]2C[C@@H1](C(=O)OC)C2)C1 N=C1C=C(C(=O)N[C@@H1](C(=O)N2CC(F)(C3CC3)C2)C4CC4)[NH1][NH1]1 C=C1CCC(C(=O)N2C[C@@H1]3CCC[C@@]3(NC(=O)C4=CC=C(C(N)=O)S4)C2)CC1 C=CCCC(F)(F)C(=O)N1CC[C@](C)(CNC(=O)[C@H1](O)C2=CN(C)N=C2C)C1 CC[C@@H1](C(=O)N(C)C[C@@H1](C)NC(=O)C=1C=C(C(F)(F)F)N(C)N=1)N2C=NC=N2 CC(=O)NCC1=CC=CC(CN(C)C(=O)C2=C(C)N=C3SC=CN23)=C1 CC(C)C[C@H1](CNC(=O)C(C)(C)C=1C=NN(C)C=1)NC(=O)C=2N=NN(C)C=2N CCCC[C@](C)(F)C(=O)N1CC(NC(=O)C2=CC=C3C(=C2)N=C(O)N3C)C1 C=CCCCCNC(=O)[C@H1](CCC)CNC(=O)C(C)(C)C(C)(C)O CC(=CC(=O)N1CCC[C@H1]2[C@@H1](NC(=O)[C@@H1]3SCC=C3C)C(C)(C)[C@@H1]21)C(C)(C)C CCC(=CC1=CC=CC=C1)C(=O)N[C@](C)(CNC(=O)CCCCC#N)CC(C)C C[C@](NC(=O)C(F)(F)F)(C(=O)OCC1C[C@H1]2CC[C@H1](C1)C2)C(F)(F)F CC[C@H1](C)C(=O)N1CCC12CN(C(=O)C3=CC=C(O)C=C3C)C2 COC1=NC=CC=C1C(=O)N[C@H1]2C[C@H1](CNC(=O)[C@@H1]3CC[C@@H1](C(C)C)NC3=O)C2 NC(=O)C1=CC=CC(OCC(=O)N[C@@H1]2CCC[C@H1](NC(=O)C=3C=C[NH1]N=3)C2)=C1 O=C(COC1=CC=CC=C1O)N[C@H1]2CC[C@H1]2CNC(=O)C3=CSC(CO)=N3 CC1=NC(CC(=O)N2CC(O)(CN(C)C(=O)C3(C4=CC=CC=C4F)CC3)C2)=CS1 CC(=O)NCCNC(=O)C(=O)N1C[C@@H1](F)C[C@H1]1CN(C)C(=O)C(C)(C)O CC(C)(CNC(=O)C1C2C(=O)C3CC1C2C3)N4CCC5=CC=CC=C5C4 CC[C@@H1](COC)C(=O)N1CCC[C@@H1](CNC(=O)C2=CSC(Br)=C2)CC1 CC1=CC(C(=O)N2CCC[C@H1]3CN(C(=O)CC=4C=C[NH1]C(=N)C=4)CC[C@H1]32)=NS1 CC1=CSC([C@H1](C)C(=O)N2CC[C@H1](NC(=O)C3=C(C)C=CN3C)C2)=N1 COC(OC)C(=O)NC12CC(C1)N(C(=O)C[C@H1]3CCN3C(=O)OC(C)(C)C)C2 C=C1CCN(C(=O)CCOCC2CCC2)[C@H1](C(=O)NCCC(=O)OCC)C1 CN(CCC1CCOCC1)S(=O)(=O)C2=CC=CN=C2N[C@@H1]3CCCC[C@H1]3F CCCCCCC(=O)NCCC[C@H1]1CCCN1C(=O)CC(C)(C)O CCCCN(C)C(=NCC1=CC=C(F)C(Cl)=C1)NCC(=O)NC(C)C CC1=C(C(=O)N2CCCC[C@@H1]2CNC(=O)CNC=O)OC3=C(C)C=CC=C13 CC(=O)[C@H1](C)C[C@@H1](C)C(=O)N[C@@H1](C(=O)NCC1CSC1)C2CCC2 N=C(N)SCC(=O)NC[C@@H1](NC(=O)C1=CN=CC(O)=C1)C2CCCCC2 C[C@H1](C(=O)N[C@H1](C)CCCNC(=O)C1CC(C)(C(C)(C)C)C1)C2=CC=CO2 CC1(C)[C@H1]2CC[C@@]1(C(=O)N3CCC[C@H1]3CC(=O)NC[C@@H1]4CCC5(CC5)C4)C2 C#CCC(=O)N1CCC12CN(CC3=CC(C)=C(Br)C=C3F)C2 C#CC1(N(C)C)CN(C(=O)C(C)(C)[C@H1]2CCCN2C(=O)C(=O)N(C)C)C1 CC1=CC(C(=O)N[C@H1]2COC[C@H1]2C(=O)N3C[C@H1](C)CC(C)(C)C3)=CC=C1O CC(C)(CS(C)(=O)=O)C(=O)N1CC(CNC(=O)CC2=CC=C3N=C[NH1]C3=C2)C1 O=C(NCC1=CC=C(O)N=N1)CC23CCC(F)(CC2)CC3 O=C(C=CCO)NC1C[C@@H1]2CCC[C@H1](C1)C2NC(=O)C3=CC(C(F)F)=CS3 O=C(NC1=CC=C2C(=C1)CCN(C(=O)C3=NC=CS3)C2)C4=CC=CC(F)=C4Cl C[C@H1](C(=O)N[C@H1]1CCO[C@H1](CNC(=O)CCCCN2C=CN=N2)C1)C3(O)CCC3 CN(C(=O)[C@H1]1CC=CCN1C(=O)[C@@H1]2CCOC2)C(CF)CF C=CC[C@H1](C)C(=O)NCC=1C=CSC=1C(=O)N2C[C@H1](O)[C@H1](O)C2(C)C CSCC[C@@H1](O)CC(=O)N1CC[C@@](CF)(NC(=O)C2=CC=C(C)C=C2F)C1 CO[C@@H1]1COC2=CC(C(=O)NC3=CC=CC(OC4=NC=CN4C)=C3)=NN2C1 COC1(C(F)F)CN(S(=O)(=O)C2=CC=CN=C2NC[C@H1](C)C3CCCCC3)C1 CCN(CC(=O)N1CCO[C@@H1]([C@@H1](C)NC(=O)C(=O)N2CCC(C)CC2)C1)C3CC3 CC(C)(CNC(=O)C1(CC(F)(F)F)CC1)NC(=O)C#C[C@@H1]2CCOC2 CC(C)S[C@@H1](C)C(=O)N[C@@H1](C)CCNC(=O)C1(NC2=CC=CC=C2)CC1 CC[C@@H1]1[C@@H1](C(=O)NCC[C@@H1](C)NC(=O)C2=CN=C(C)N=C2C)CCN1C CCN(C(=O)C1=CC=NC(OC)=C1)[C@@H1](C)CNC(=O)CC2=CN=C(C)[NH1]2 FC1=CC(Br)=CC(Cl)=C1CNC2=CN=CC(C3CCCC3)=N2 C#CCCCC(=O)N(CCC)CCNC(=O)[C@@H1](O)C(C)(C)C CCC=1ON=CC=1C(=O)N[C@H1]2CCCCC[C@@H1]2NC(=O)[C@@H1](C#N)CC C[C@@H1](OC1CCCCC1)C(=O)NC[C@@H1]2CC(C)(C)CN2C(=O)C3=C[NH1]C(=N)S3 CC(C)C1=NC=C(Cl)C(C(=O)N2CC[C@@](C)(NC(=O)[C@@H1](O)C(F)(F)F)C2)=N1 CC1=CC=C(C(=O)N2CSC[C@H1]2C(=O)N3C[C@]4(CO)C[C@]4(CO)C3)C=C1O CCC=1C=NN(CC(=O)N[C@H1](C(=O)NC2=CC=C(F)C=C2C)[C@@H1](C)CC)C=1 CC1=N[NH1]C=C1C(=O)N2CC[C@@H1](CC(=O)NC3=CC=NS3)C2 CN(C(=O)[C@H1]1CCCO1)C2CC(C(=O)N[C@H1]3C(=O)O[C@H1]4CCC[C@H1]43)C2 CC(C)(C)OC(=O)N1C[C@@H1](O)[C@@H1](O)[C@@H1]1CNCC2CC3(CC3)C2 CCS(=O)(=O)CC(=O)N1C[C@H1]2[C@H1](NC(=O)C3=CON=C3COC)[C@H1]2C1 C#CCCN1C=C(NC(=O)[C@@H1]2CCN2C(=O)C3=COC=N3)C=N1 CCC[C@@H1]1CN(C(=O)CC(C)(C)C2CC2)CCN1C(=O)C3CC4(CC4)C3 C=C(CCNC(=O)[C@@H1]1C[C@@H1]1C2CCCC2)CNC(=O)C3=CC(F)=CC=C3F CC1=CC(Cl)=C(C(=O)N2CCO[C@H1](CNC(=O)[C@@](O)(C3CC3)C(F)(F)F)C2)S1 O=C(N[C@H1]1C[C@@H1](CNC(=O)C2=CC(Br)=CC3=C2OCC3)C1)C4=CC(O)=NC=N4 CCN(C(=O)CN(C)S(C)(=O)=O)[C@@H1]1CCN(C(=O)CC2CCSCC2)C1 CN(C)C[C@H1](O)C(=O)N[C@@H1]1CN(C(=O)C2=C(Cl)C=NN2C)C[C@@H1]1N=[N+1]=[N-1] CCC[C@H1](C(=O)N[C@@H1]1CCN(C(=O)C2=CC(O)=NC(Cl)=C2)C[C@H1]1CC)C(C)C CC=1ON=C(C2=CC=CC=C2Cl)C=1C(=O)N3CCN(C)C4=CC=CC=C43 C=C(C)C[C@H1](OC)C(=O)NCCC1(C)CCN(C(=O)C2=CC(C3CC3)=NS2)CC1 CC/C=C/CC(=O)N[C@@H1](C)C1(O)CN(C(=O)C2=NN(C)C=C2S(N)(=O)=O)C1 C=C1C[C@H1]1C(=O)N2C[C@@H1](F)C[C@H1](NC(=O)COCC(=C)C)C2 CCN=C1[NH1]C=C(C(=O)N(CC)CC2CCN(C(=O)C3CCCC3)CC2)S1 CCCN(CCNC(=O)C1=CN=C(C(F)F)S1)C(=O)C2=C([N+1](=O)[O-1])C(C)=NN2C CC1=N[NH1]C(C)=C1CC(=O)N[C@@H1]2CC[C@@H1]3CN(C(=O)COC4(C)CCCC4)C[C@@H1]32 CCC(CC)(CO)C(=O)NC1CC(O)(CN2C=C([C@@]3(O)CCOC3)N=N2)C1 C[C@H1](C(=O)NCCCC(C)(C)NC(=O)[C@H1](F)C1CCC1)C2(O)CCC2 COC1=CC(Br)=C(CCNC(=O)C2[C@H1](C)[C@H1]2C)C=C1OC N#CC1=CC=C(SCC(=O)N2CC3(CCN3C(=O)CCC4=CC=CS4)C2)C=C1 C[C@@H1](CCNC(=O)C[C@@H1]1C=CS(=O)(=O)C1)CCNC(=O)C2=CC(Cl)=NN2C C=C(C)CC(=O)N1CC[C@H1](C)[C@H1](CNC(=O)C2(CSC)CC(F)(F)C2)C1 O=C(N[C@H1]1C[C@@H1](CNC(=O)C2(O)CCCC2)C1)C3=CC=C4C(=C3)C(=O)OCC4 CO[C@]1(C(=O)N2CCC3(CC2)CC(NC(=O)C4=CC=NC=N4)C3)CCSC1 COC(=O)N(C)CCCC(=O)NC[C@@H1](O)CN(C)C(=O)C=1SC([N+1](=O)[O-1])=CC=1Cl CC[C@H1](O)CN(C)C(=O)[C@@]1(C)CN(C(=O)[C@H1](O)CSC)C(C)(C)C1 C[C@H1](NC(=NCCOC1(C)CCC1)NC2(CC3CC3)CC2)C4CC4 CC1=NC=2SC=CC=2C(=O)N1NC(=O)[C@@H1]CF CN(C)[C@@H1](C(=O)N[C@H1]1CCCC[C@H1]1NC(=O)C2=CC(F)=C[NH1]2)C3=CN=CN3C CCC(CC)CCCC(=O)N(C)[C@@](C)(C(=O)N1CCC[C@H1](CF)C1)C2CC2 CCCN(CC)CCNC(=O)[C@H1]1CN(C)CCN1C(=O)CCCCCC O=CNCC(=O)N1CCO[C@H1]2CN(C(=O)C3=CON=C3C(F)(F)F)C[C@H1]21 O=C(O)C1=CC2=C(C(N[C@H1]3C4C[C@@H1]5CC(C[C@@H1](C4)C5)[C@H1]3C)=C1)OCC2 CN1C=NC2=C(N3C[C@@H1](F)C[C@@H1]3C(=O)NC4=NC(O)=CC=C4[N+1](=O)[O-1])N=CN=C21 CCOC1CCN(C(=O)[C@H1]2CCCC[C@@H1]2NC(=O)C3=CC=C(OCCOC)C=C3)CC1 CC1=NN(C)C(F)=C1C(=O)N(C)C[C@H1]2CCN(C(=O)/C=C/[C@H1]3CCCO3)C2 C#CC1=NC(C(=O)N2CCC[C@]3(NC(=O)C4=CC=NC(OC)=C4)CCC[C@H1]23)=CS1 CN(C)C(=O)CCC(=O)NC[C@@H1]1CN(C(=O)C2=CN=C(S)N2C)[C@H1]3COC[C@@H1]3O1 NC(=O)C1(C(=O)N2CCN(C(=O)C3=CC=C(O)C(Br)=C3)[C@H1](CF)C2)CC1 COC1=NC=NC(N2CCC[C@]3(CCCN(C(=O)CCCC(C)C)C3)C2)=C1C COC[C@@](C)(O)CNC(=O)C1=CC=C(C2=CC=CC(F)=C2)S1 CCCCC=1OC=NC=1C(=O)N(C)C[C@]2(O)CCCN(C(=O)C=3C=C(F)N(C)N=3)C2 CC[C@](C)(C(N)=O)C(=O)N[C@@H1](C)CCCNC(=O)C1=CC=CC=C1C(N)=O COC(=O)C1CN(C(=O)[C@@H1]2[C@H1](O)CCN2C(=O)C3=CC=C(C(N)=O)O3)C1 C=CCCO[C@H1](C)C(=O)N(C)[C@@H1](C)CNC(=O)C1=CC(OC)=C(N)C([N+1](=O)[O-1])=C1 O=C(C=CBr)N[C@@H1]1CCC[C@H1]1CNC(=O)C2=C(O)C=C(O)C=C2O CNC(=O)[C@]1(C)CCN1C(=O)[C@H1]2CN(C(=O)C3=CN=NN3C4CC4)C[C@@H1]2C(C)C C[C@@H1](OC1=CC=C(F)C(F)=C1)C(=O)N[C@H1]2C[C@H1](CNC(=O)CCCC3CCC3)C2 CC(=O)N1CC[C@H1](N[C@](C)(C2=NN=NN2C(C)(C)C)C3CCSCC3)C1 CC1=CN2C=C(C(=O)N[C@H1]3CCN(C(=O)CSC4=CC=CC=C4)C3)C=C(F)C2=N1 CC[C@@]1(C(=O)N2CCC[C@H1](N(CCO)C(=O)CCCC#N)C2)CCCO1 CC1=CC=NC=C1C(=O)N2CCN(C(=O)C3=CC=CC(CCO)=C3)[C@H1](C(C)C)C2 C[C@@]1(CNC(=O)CC=2C=CON=2)CC(F)(F)CN1C(=O)[C@@H1]3CCSC3 O=C(N=C1C=CN(CC2CC2)[NH1]1)[C@@H1](F)[C@H1]3CCN(C(=O)C4CC5(CCC5)C4)C3 C[C@@]1(CNC(=O)C[C@]23CCC[C@@H1]2C3)CCN(C(=O)C4=C(F)C(F)=CC(F)=C4F)C1 CCO[C@@H1]1[C@H1](C)[C@H1]1C(=O)N2C[C@H1]3[C@H1](NC(=O)C4=CC=C5C(=C4)N=C(C)N5C)[C@H1]3C2 C=CCOCCCC(=O)NCCOCCCN(C)C(=O)[C@@H1]1CCCCN1CCC CCC1=CC(C(=O)N2CC[C@@H1](N(C)C3=CC=CN=C3Br)C2)=NO1 CCN(C)[C@H1]1C[C@@H1](C(=O)N2C[C@@H1](C)[C@@H1](NC(=O)[C@]34CSC[C@H1]3C4)C2)C1 CS[C@@H1](C(=O)N1CC2(CN(C(=O)CN3C=CC=CC3=O)CCO2)C1)C(C)C C[C@H1](CC(=O)N1C[C@@H1]2CCC[C@H1](C1)N2C(=O)C3(F)CC=CC3)CC(F)(F)F C=CC[C@H1](CNC(=O)CCC1=CN=C(C)S1)NC(=O)[C@]2(N(C)C)CCCOC2 CN(CCC1CCN(C(=O)CCC2=CC=C(Cl)S2)CC1)C(=O)[C@@H1]3CCC34CCC4 COCC1(COC)C[C@@H1]1C(=O)OC[C@H1]2CCN(CC3=CC=CC=C3)C2 CCS[C@@H1](C)C(=O)N1CC[C@](OC)(C(=O)N[C@@H1]2CC[C@H1](O)[C@H1](O)C2)C1 CC(=O)NCCNC(=O)[C@@H1]1C=CCCN1C(=O)[C@@H1](C)N2N=CC=C2C CCC=1C=NN(CC(=O)NCCCOCCC(=O)NC2(CC)CCC2)C=1 CN1C=C(C2(NC(=O)[C@@H1]3CCO[C@@H1]3CNC(=O)C4=CC=C(CO)S4)CC2)C=N1 CC(=O)CCC[C@@H1](C)C(=O)N[C@@H1](CN1C=NC=N1)C(=O)N2CCN(C)C(=O)C2 CCN(C(=O)C=1C=CSC=1C)[C@H1](C)CNC(=O)C2=CN=C(SC)N=C2O C[C@@H1]1CN(C(=O)C2(F)CCCC2)C[C@H1]1NC(=O)[C@H1](F)CC3=CC=C([N+1](=O)[O-1])C=C3 CC1=NC(CN2CCC[C@@H1](CN(C)N(CCCO)CC3=NC=CS3)C2)=CS1 CC(C)/C=C/CCC(=O)N1CCN(C(=O)[C@]2(C)CCC[C@H1]2O)CC3(CC3)C1 CCOC[C@@H1](C)NC(=O)CCN1CCC(C)CC1 COC1CC(C(=O)N2CCC3(CC2)C[C@@H1](NC(=O)C4=C[NH1]C=C(F)C4=O)CO3)C1 COCC(=O)NCC1(CNC(=O)C2=CC=C3C=CSC3=C2)C[C@@H1]4CCC[C@H1]4C1 O=C(NC1(CCNC(=O)[C@@H1]2COCCO2)CC1)C3=CC=C4N=C[NH1]C4=C3 COC[C@H1](O)C(=O)N[C@@H1](C)C1(O)CN(C(=O)CCCC2=NC3=CC=CC=C3[NH1]2)C1 CC(C)C[C@@H1]1C[C@H1](NC(=O)CN2C=CC3=CC=C(F)C=C32)CCO1 CCOC1=CC=C(CC(=O)N2CCC(N=C3N=C[NH1]C=4[NH1]C(Cl)=CC3=4)CC2)N=C1 N#C[C@H1]1CC[C@@H1]1C(=O)N2CC=C[C@H1](C(=O)NCCC#CCO)C2 CCN(C(=O)[C@@H1]1[C@H1]2[C@H1]3C[C@H1]1[C@H1](NC(=O)[C@H1](O)CN4C=NC=N4)[C@@H1]23)[C@H1]5CCNC5=O CC(C)N(C)CC(=O)N1CCC(CN(C)C(=O)C2=CC=NC=C2Br)CC1 C#CC1(C(=O)N2C[C@H1]3[C@H1](CNC(=O)CCCNC(C)=O)C[C@H1]3C2)CC1 CC1=CC(C(=O)NC2=CC=CC(CNC(=O)[C@@H1]3CCCC3(C)C)=C2)=CC(C)=C1O CSC1=CC=C(C)C(C(=O)N(C)CC[C@H1](C)NC(=O)COCC2=NC=NN2C)=C1 CCC1=CC(C(=O)N[C@H1](C(=O)N2CC[C@H1](COC(C)=O)C2)[C@@H1](C)CC)=NN1C O=C(C[C@@H1]1C=CCC1)N2CCC[C@H1](CNC(=O)C3(F)CCC3)C2 CSCC(=O)N[C@@H1](CNC(=O)COC1=CC=CC(C)=C1)C2CC2 CN1N=CC2=C(NCC3(S(C)(=O)=O)CC3)[NH1]C(=NC[C@@]4(C)CCCO4)N=C21 CCC=1N=C(C)OC=1C(=O)N(C)C[C@]2(O)CCN(C(=O)[C@](C)(O)COC)C2 CC(=O)N1CC[C@](C)(C(=O)NCC2(NC(=O)[C@@H1]3CCC4=NC=NN4C3)CCC2)C1 CCS[C@H1](C)C(=O)N[C@H1]1CCN(C2=NC=NC(Cl)=C2C(=O)OC)CC(C)(C)C1 CC(C)(CNC(=O)C1=CN=C2C=CC=C(Cl)C2=C1)NC(=O)C=3C=C(CCO)ON=3 CC1=CC(C(=O)NCC2=NO[C@H1]3CN(C(=O)CC4=C[NH1]N=C4O)C[C@@H1]23)=CC=C1Cl CCCCCC[C@@H1](C)C(=O)N1C[C@@H1](O)[C@@H1](CNC(=O)C2=NC(OC)=CC=C2F)C1 C=C(Cl)CCC(=O)NC(CC)(CC)CCNC(=O)[C@@H1]1CCOC2(CCCCC2)C1 O=C(NCCC1CCCC1)[C@H1]2CC23CCN(C(=O)/C=C/CBr)CC3 CC(C)(C)OCCCC(=O)N1C[C@H1](C(=O)N(CCO)CC(F)F)[C@@H1](C2CC2)C1 CC1(C)OC[C@H1](C=CC(=O)N2C[C@@H1]3C[C@H1]2[C@@H1]3NC(=O)C4=CC=CC(F)=C4F)O1 O=C(CNS(=O)(=O)C1=CC=CS1)N[C@H1]2CC(F)(F)C[C@H1]2NC(=O)[C@@H1]3CCO3 CC1=CC=C([C@H1](F)CNC(=O)C2=CC(Br)=C3C(=N2)CCCN3)C=C1C CC1=CC=CC(C(=O)N2CC[C@H1](NC(=O)CN3C=NC=C3C)[C@H1](O)C2)=C1N CN(C(=O)[C@@H1]1CCCCO1)[C@@H1]2CN(C(=O)C3=CC=C4N=CC=NC4=N3)C[C@H1]2O N#C[C@]1(C(=O)N2C[C@H1]3[C@@H1]4C=C[C@@H1](CC4)[C@H1]3C2)C[C@H1]5CC[C@H1]1C5 CN(C)C[C@@H1](O)CN(C)C(=O)C=1C=CN(CCNC(=O)[C@H1]2CC3=NC=CN3C2)C=1 CCC[C@@H1](OCC)C(=O)N(C)C[C@H1](O)CN(C)C(=O)C=CC1=CC=C(C#N)C=C1 C[C@H1](CNC(=O)[C@@]1(NC(=O)CN2CCCC2=O)C[C@H1]1C)CN3C=CN=C3 C[C@H1]1CCO[C@H1](C(=O)NCCCC[C@@H1](C)NC(=O)C2=NC=NC(O)=C2F)C1 CC1=CC(C(=O)N2[C@H1](CNC(=O)[C@H1]3CC(C(C)C)=NO3)C[C@@H1]4C[C@@H1]42)=C[NH1]1 CC(C)C1CC(C(=O)N[C@@H1]2COC3(C2)CN(C(=O)[C@@H1](C)[C@@H1](C)S(C)(=O)=O)C3)C1 CC1(CNC(=O)C[S@@](=O)C(F)(F)F)CCN(C(=O)CC2=CC=C(O)C=N2)CC1 CC(C)CCOCC(=O)N[C@@H1]1C=C[C@H1](CC(=O)N2C[C@@H1]3[C@@H1](C2)[C@H1]4C=C[C@H1]3O4)C1 CCCSCC(=O)N[C@H1]1CCCC[C@H1]1C(=O)NC[C@](C)(O)CSC CN(C)C(=O)C(=O)N[C@@H1]1CC[C@@H1](CNC(=O)[C@@H1]2[C@H1]3COC(C)(C)OC[C@H1]32)C1 CC(C)=CC(=O)N(CCNC(=O)C1=C(C)N=C2SC(C)=NN12)CCOCCO C=CC[C@H1](CC(F)F)C(=O)N1CC[C@@](CNC(=O)C2=COC=N2)(OC)C1 CCN1CCCC[C@H1]1C(=O)NC[C@@H1]2C[C@@H1](OC)CN2C(=O)/C=C/C3(C)COC3 CC=1C=CN2C(=O)C(C(=O)N3C[C@@H1]4C[C@H1](NC(=O)[C@H1]5CC5(F)F)[C@H1]3C4)=CN=C2C=1 C#CC1=CC=CC(OCC(=O)NC[C@](C)(O)CNC(=O)C[C@@H1]2CCNC(=O)C2)=C1 CCC[C@H1](O)C(=O)NCC1(C(=O)N[C@H1]2C[C@@H1](C3=CC=CC=C3)C2)CC(C)C1 C[C@H1](CCO)CNC(=O)[C@@H1](CNC(=O)C=1C=COC=1)CC2CC2 CCS(=O)(=O)N(C)CC(=O)N[C@H1]1C[C@@H1](CNC(=O)[C@@H1](C)[C@@H1](O)C(C)C)C1 CCC1=C[NH1]N=C1C(=O)NC[C@@H1](CO)CNC(=O)[C@H1]2CCN(C(C)=O)C2 CC1=CC=C(F)C=C1C(=O)N2CC[C@H1](C(=O)NC3CCN(C4CC4)CC3)O2 CN1N=C(O)C=C1C(=O)N2CC[C@@H1](CCN=C3[NH1]C=C([N+1](=O)[O-1])C=C3C#N)C2 CC1=NSC=C1C(=O)N2CC3CC2(CNC(=O)[C@@H1]4CCN(C)[C@H1]4C)C3 CC[C@H1](CC(=O)N1C[C@]2(C(=O)NCC3(CCO)CCC3)C[C@H1]1CO2)OC CCC1=NC(C)=C(C(=O)N2CC3CC2(C(=O)NC=4C=NN(CCOC)C=4)C3)O1 CCN1C=C(C(=O)N[C@H1]2C[C@@H1](NC(=O)[C@@H1]3CCC4=NN=C(O)N4C3)C2)N=N1 O=C(NCCC1=CC=CN=C1O)[C@@H1]2[C@@H1](C3CC3)CCN2C(=O)C=C4CCC4 C[C@H1]1CC(C2CN(C(=O)C3(C)CC3)CC2)CN1C(=O)C4=N[NH1]C5=CC=C(F)C=C45 COC1=CC=C(C=2N=C([C@H1]3CCC(=O)NC3)N(C4CC4)N=2)C=C1Cl CC1=CC(C(=O)N[C@@H1]2CCCCC[C@H1]2NC(=O)C3=CC=CC=C3CN(C)C)=NO1 C[C@H1](CNC(=O)[C@H1]1C[C@H1](N(C)C)C1)NC(=O)[C@H1](CC=CCl)C2=CC=CC=C2 O=C(N[C@@H1]1CCCN(C(=O)C2(C(F)(F)F)CC2)C1)C34CC(C3)[C@H1](C(F)(F)F)O4 C#CCC1(O)CCN(C(=O)[C@@H1]2CCC[C@@H1](NC(=O)C3(C)CC(F)(F)C3)C2)CC1 COCCN(CCNC(=O)C1=CCCCC1)C(=O)[C@@H1]2CC[C@H1]2C CCCC(CCC)C(=O)N1CCC[C@H1](CNCC2=CC=NC(Br)=C2)C1 CC(C)NC1=CC(N(C)C(=O)[C@@]23C[C@H1](C4=CC=CC=C4)[C@@H1]2C3=O)=NC=N1 CCC=1N=N[NH1]C=1C(=O)N[C@@H1]2CCCCN(C(=O)[C@H1]3CCO[C@H1]3C)C2 NC1=CC(NCC=CC2=CC=CC=N2)=C(C(=O)O)C=C1Cl CC[C@H1](CC(=O)NCCCCNC(=O)C1(C2=CC=C(F)C=C2)CCC1)C3CC3 CCCN(C(=O)[C@H1](CC)CN(C)C)[C@H1]1CCN(C(=O)C2=C[NH1]N=C2C)C1 CCC(C)=C(C)C(=O)N[C@H1]1C=CCC[C@H1]1C(=O)NC[C@@H1]2NC(=O)NC2=O CO[C@@H1]1CCN([C@H1]2CCS(=O)(=O)C2)C[C@@H1]1C C[C@@H1](CCNC(=O)C1=CSC(C(N)=O)=N1)NC(=O)C=2C=NN3C=CC(C#N)=CC=23 CC1=CC=CC2=C(N(C(=O)CCN3CCOC3=O)[C@H1]4C[C@H1](N)C4)N=CN=C12 C=C(C)[C@H1]1OCC[C@H1]1C(=O)N(C)[C@@H1](CC)C(=O)N2CC3(COC(C)(C)C3)C2 CC(C)C=1[NH1]N=C(C(=O)NCCCN(C)C(=O)[C@@H1]2COC(=O)N2)C=1Br C[C@H1](CN(C)C(=O)CN1CCOCC1)NC(=O)C=2C=NN3C=2OCC4(CC4)C3 CN1C[C@H1](C2=CC=CC=C2)[C@@H1](C(=O)NC[C@H1]3C[C@H1]3NC(=O)CC#N)C1 O=C([C@H1](O)C1=CC=CC=C1)N2CCC(O)(CCN=C3C=CN=C(C4CC4)[NH1]3)CC2 COC1CC(CNC(=O)[C@@H1]2CCC[C@H1](CF)C2)(NC(=O)C3=CC=C(C)C(O)=N3)C1 COC1=CC=C(C(=O)N2CC[C@@H1](C)[C@@H1](NC(=O)C(C)(C)C3CC3)C2)N=C1OC CO[C@@H1]1C[C@H1](CNC(=O)C(C)=CC2=CC=CC(Cl)=C2)N(C(=O)[C@H1]3C[C@H1](C#N)C3)C1 CC1=NC2=CC=CC(C(=O)N[C@H1]3C[C@@H1](CCNC(=O)CC[S@@](C)=O)C3)=C2S1 COCCCC(=O)N[C@@H1]1C[C@H1](OC)CN(C(=O)C2=CC=NC(OC(C)C)=C2F)C1 CCCC1=CC=CC(C(=O)N2CCC[C@@H1](N(CC)C(=O)C=3OC(C)=NC=3C)C2)=C1 N#CC1=CC=C(CN(C(=O)[C@@H1]2CC2(F)F)[C@H1]3CCNCC[C@H1]3C)S1 CSCC(C)(C)C(=O)NCC12CCC(CC1)N(C(=O)C3=CC=C(O)C=C3F)C2 CCC(F)(F)CC(=O)N[C@H1](CC(=O)NCCC[C@@H1]1CCCCO1)CC2CC2 CCCCC(=O)N1CCN(C(=O)CN(C)C(=O)COC2=CC=C(Cl)C=C2)CC1 CC[C@@](C)(CCNC(=O)[C@H1](C)NC(C)(C)CC)NC(=O)[C@H1]1CCC[C@H1]1F CC=1ON=C(C(=O)N[C@@](C)(CO)CNC(=O)C=2N=C(C)N3C=2CCCC3)C=1Br O=C(NC1(CO)CCN(C(=O)C2CC=CC2)CC1)C3=CC=NC(C4CCC4)=C3 CSC1=CC(C(=O)N2C[C@H1](NC(=O)C3C[C@H1]4C[C@@H1]4C3)CC25CCC5)=CC=C1F CC(=O)OC[C@H1](C)C(=O)N1CCC[C@@H1]1CNC(=O)COC2CCCC2 O=C1N[C@@H1](CC(=O)N2CC[C@H1](NC(=O)C3CC4(C3)OCCO4)C2)CO1 COCC1=CSC(C(=O)N[C@H1]2CN(C(=O)[C@]3(C)CC=CCO3)CC4(CC4)C2)=C1 CCC1=CC=C(C(=O)NC[C@]2(O)CCCN(C(=O)C(C)(C)O)CC2)C=C1 O=C(COC(=O)CN=C1C(Br)=CC(F)=CN1NO)OCC2=CC=CC(Cl)=C2 CC(C)C1=NC=CC(C(=O)N[C@H1]2C[C@@H1](CN=C3C=C(C(N)(C)C(=O)NCC)N=C3)C2)=N1 CO[C@@H1](CN1CCC[C@@H1]1CCCNC(=O)CCOC(C)C)C2CCCC2 CCC(C)(CC)C(=O)N1C[C@H1]2[C@H1](CC(=O)NC3(C)CCC(O)CC3)[C@H1]2C1 NC1=CC=CC(F)=C1C(=O)N2CCC[C@H1](CNC(=O)CN3C=NN=C3O)CC2 CC1=CC(C)=CC(N2N=CC(NC(=O)[C@@H1](N)CCC(C)(F)F)=C2C)=C1 C[C@@]1(C(=O)NCCNC(=O)C2=CC=NC3=CC=C(N)C=C23)CCNC(=O)C1 COC[C@@H1]1CN(C(=O)C2=NN=C(S)N2C)CCN1C(=O)C=3C=NN(CCF)C=3 CC=1N=CSC=1COCC(=O)NCC[C@H1]2CN(C(=O)[C@H1](O)C(C)C)CCCO2 CSC1=CN(C)N=C1C(=O)N2CC(C)(NC(=O)CC3=CSC(C4CC4)=N3)C2 COCCNC(=O)[C@@H1](C1=CSC(C)=N1)N2CCC[C@@]3(COCC(=O)N3)C2 COCC(=O)N(C)CC(=O)NC[C@]12CCC[C@H1]1N(C(=O)[C@H1]3CC3(F)F)CCC2 CC1=CN(C)N=C1C(=O)NCCCC2CCN(C(=O)CC3CCC3)CC2 CC(=O)NCC(=O)N1CCN(CC(=O)NC[C@@H1](C)C2=CC=CC=C2)C(=O)C1 COC1=NC=C[NH1]C1=NC(=O)[C@@]2(C)CCN(C(=O)C3=C(F)C=CC=C3F)C2 CN(CCN1CCN(C(=O)C2(CO)CCC2)CC1)C(=O)C3(C)CC4(CCC4)C3 C[C@@H1](C(=O)N1C[C@@H1](CC(=O)NC2=CN=CC(CO)=C2)C3(CC3)C1)N4CCCCC4 COC1=CN=C(C(=O)N2CC[C@H1](NC(=O)[C@H1]3C[C@@H1]3C(C)C)[C@H1]2C)C(F)=C1 COCC=1N=CSC=1C(=O)N2CCC[C@H1](C)[C@@H1]2CNC(=O)C3=CC([N+1](=O)[O-1])=N[NH1]3 CCC[C@](C)(O)C(=O)N1CC2(CC(CC(=O)N(C)C=3C=CSC=3)C2)C1 CC(C)CC1=N[NH1]C(=NC[C@@H1]2CCC[C@@H1]2NC(=O)C3[C@@H1]4COC[C@@H1]34)S1 O=C(NCC[C@@H1]1CN(C(=O)C2=NSC3=CC=CC=C23)CCO1)[C@H1]4CC4(Cl)Cl O=C(C1=C(F)C=C(O)C=C1F)N2C[C@@H1]3C[C@H1](C2)N3C(=O)CCC4=CN=CN=C4 CC(C)OC1=CC(F)=CC=C1NC(=O)[C@]23C[C@H1]2CN(C(=O)C(C)(C)F)C3 CCC1=NON=C1C(=O)N2CCC([C@H1](C)NC(=O)[C@H1]3CC(C)=NO3)CC2 COC1=CC=C(NC(=O)C(=O)N2CCN(CC3=CC=CC=N3)CC2)C=C1C COC(=O)[C@@H1]1C[C@H1]1C(=O)NC2=CC(Cl)=CC=C2C(=O)NC3=CC=C(Br)C(C#N)=C3 CN1C=C(C[C@@H1](CO)NC(=O)[C@@](C)(NC(=O)C(N)=O)C2=CC=CC=C2)C=N1 CC1=CON=C1C=2[NH1]C(=NC3C[C@@H1](C)[C@@H1](CO)C3)C=CC=2F COCN1C=CC(C(=O)N[C@@H1]2CN(C(=O)[C@H1](C)SC)C3(CCC3)C2)=N1 C=C[C@@H1]1C[C@H1]1C(=O)NCC2(CNC(=O)C3=CC=CC(OC(C)C)=C3F)CC2 CCOC1CC2(C1)C[C@@H1]2C(=O)N(CCO)[C@H1]3CCN(C(=O)CC4=CSN=C4C)C3 C=CC[C@H1](C(=O)N[C@](C)(CNC(=O)C1=CN(C(C)(C)C)C=N1)C2CC2)C(C)C CN(C)C(=O)C(C)(C)C(=O)N[C@@H1]1C[C@H1](NC(=O)[C@@H1]2CN3CCC2CC3)C14CCC4 C[C@@](O)(C(=O)NC[C@]1(F)C[C@H1](NC(=O)[C@H1]2CC23CCCCC3)C1)C4=CC=CC=N4 C=CC1(CC(=O)NC2C[C@H1]3CN(C(=O)C4CCSCC4)CC[C@@H1]3C2)CCOCC1 CN1C=C(CCC(=O)NC(C)(C)CCCNC(=O)[C@@H1]2[C@H1]3CNC(=O)[C@H1]32)C=N1 CCCC[C@@H1](C)C(=O)N1CCN(CCNC(=O)[C@@H1]2CC[C@@H1](C)O2)CC1 O=C(NC[C@@H1](F)Cl)C1(F)CN(C(=O)[C@]23CSC[C@@H1]2C3)C1 C#C[C@@H1](NC(=O)[C@H1]1CCCN(C(=O)C#CC2(C)COC2)[C@H1]1CC)C3CC3 CCOC(=O)[C@@]1(C(C)C)CCN(C(=O)NC2=CC(F)=CC=C2OCC3NCC3)C1 CO[C@@H1]CCNC(=O)[C@@]12CC[C@@H1](CN(C(=O)[C@@H1](C)C3(O)CCC3)C1)C2 CCC1=NC(C(=O)N2CC[C@](C)(NC(=O)[C@@H1](C)NC(=O)CN3C=NN=N3)C2)=CO1 CCC=CC=CC(=O)N[C@@H1](C)CCNC(=O)C1=COC2=CC=CC=C12 CCC1=NOC=C1C(=O)NC[C@H1](O)CNC(=O)C2=CN=C(O)C(Cl)=C2 COC=1C=C(CC(=O)NC[C@@H1]2CCN2C(=O)/C=C/C(=O)C3=CC=C(F)C=C3)ON=1 C/C=C/CCCCC(=O)N1CCC[C@H1](N(CCF)C(=O)C=2N=C(C)OC=2OC)C1 CNC(=O)CN[C@@H1](C1=CC=CC(COC)=C1)C2=NN=NN2C(C)(C)C CC(C)(CNC(=O)CC1=CC=CC=C1[N+1](=O)[O-1])NC(=O)C2CC(CCO)C2 COC1=CC=CC(CN2CCO[C@H1](CNC(=O)CCCC3=CC=CC=C3)C2)=C1 CCC1=NC(NC[C@@H1]2CCC[C@H1]2NC(=O)C3=CC=CC=C3OC)=C4C=CSC4=N1 CC1=C[NH1]C(C(=O)N2CC[C@@H1](CN(C)C(=O)C3=CN=C4[NH1]C=NC=C34)C2)=C1C C[C@@H1](NC(=O)C1=CC2=CC=CC=C2[NH1]1)C3CN(C(=O)CSC=4C=N[NH1]C=4)C3 CCCCCCN(CCNC(=O)CC1CCC2(CC1)CC[C@@H1]2O)C(=O)CCSC C[C@@H1](CC1CCC1)C(=O)N[C@@]23C[C@@H1]2CN(C(=O)C4=CC=CC=C4C=5C=N[NH1]C=5)C3 CC(C)(C)ONC(=O)C[C@@H1](NC(=O)C1=CC=NC(O)=C1)C(C)(C)C CCCN(CCC)C(=O)CCN(CCCO)C(=O)[C@@H1](O)C1CCOCC1 CC=1N=CSC=1CC(=O)NCC(C)(C)C#CC(=O)N2CCOCC[C@@H1]2C(C)C CC1=CC=NC(C(=O)N2CCC(NC(=O)C3(C=4C=CSC=4)CC3)CC2)=N1 COCCN1C=C(C2=NC(C3=CC=CC(Cl)=N3)=NN2[C@H1](C)C4CCC4)C=CC1=O COCCN(CCNC(=O)C1=CC(Cl)=CC=C1[N+1](=O)[O-1])C[C@H1]2CCO[C@H1](C)C2 CCC=1SC=NC=1C(=O)N[C@H1](C)[C@@H1]2CCCN(C3=CC=C([N+1](=O)[O-1])C(C#N)=C3)C2 C=CCNS(=O)(=O)C1=CC=C(CC(=O)N[C@@H1]2CC(=O)N(CC(F)(F)F)C2)C=C1 CCNC(=O)C(=O)N1CC(CNC(=O)CCN2C=C(Br)C(O)=NC2=O)C1 CC[C@H1](C(=O)N[C@H1](CC(N)=O)C1=CN([C@@H1]2COC[C@H1]2O)N=N1)N(C)C CC1=C(Cl)C=CC=C1OCC(=O)N2C[C@H1]3CC[C@@H1](C2)N3C(=O)[C@H1](C)NC(C)(C)C C[C@@]1(C(=O)NC[C@@H1](CNC(=O)CN2N=CC3=CC=CN=C32)C(F)(F)F)CCCS1 CC1=CN=CC(C)=C1C(=O)NN2CCC[C@H1]2C(=O)NC3([C@@H1]4CCCO4)CC3 CCCCC1=CC=C(OC(=O)C2=CC(O)=C(O)C([N+1](=O)[O-1])=C2)C=C1 CC(C)(O)CC(=O)NC1(C(=O)N2CC[C@@H1]3C[C@@H1]32)CC(CO)C1 CN1C[C@H1](O)[C@@H1](N(C)C(=O)[C@@H1]2C[C@H1]3C[C@@H1]2C[C@H1]3NC(=O)C[C@H1]4CC(=O)NC4=O)C1 CC1=NC=C(Cl)C=C1C(=O)N[C@@]23CCCN(C(=O)CCCN4C=CN=C4C)C[C@@H1]2C3 O=C(CO)NCCC(=O)N[C@H1]1CCC[C@@H1](NC(=O)CC2=CC=C3SC=CC3=C2)C1 COC(=O)[C@@H1]1[C@H1]2[C@H1]C[C@H1]1[C@@H1](NC(=O)[C@@H1](C)NS(=O)(=O)C3=CC=C(C(C)C)C=C3)[C@@H1]2 CC[C@H1](CO)CCNC(=O)C1=C[C@H1](O)[C@H1](NC(=O)C=2C=CN3C=CN=C3C=2)C1 C[C@@H1]1C(=O)CC[C@H1]1CC(=O)NCCC2(C(=O)N3C[C@H1](O)[C@H1](O)CO3)CCC2 CP(C)(=O)C1=CC=CC(C(=O)N2CCCN(C(=O)C3=CSC(=N)[NH1]3)CC2)=C1 C=C(C)C(C)(C)C(=O)N1CC[C@H1](CNC(=O)C[C@H1]2CCC(F)(F)C2)[C@@H1](C)C1 CC[C@H1](CC(=O)NC1CC2(C1)CN(C(=O)C3=CSC(C4CC4)=N3)C2)CN(C)C COCC1=NC=C(C(=O)N[C@H1]2CC[C@H1]2CNC(=O)C(=O)N3CC[C@H1](C)C3)C(=N)[NH1]1 CC[C@H1](C)[C@H1](C(=O)NC1=CC=C(O)C=C1C)N(C)C(=O)COCCCOC C#CC(C)(C)C(=O)N[C@H1]1C=C[C@@H1](C(=O)NC2CC3(C2)CC(C)(C)C3)C1 COC[C@](O)(CO)CNC(=O)[C@](C)(CO)NC(=O)C=1N=CN(C)N=1 CC(C)[C@]1(C)C[C@H1]1C(=O)N2CCN(C(=O)CC3(C)CCCCC3)C[C@@H1]2C(C)(C)C CC[C@@H1](O)C(F)(F)C(=O)NCC[C@]1(O)CCN(C(=O)CC2=COC(C)=N2)C1 C=CCCOCC(=O)N1C[C@@H1]2CC[C@]2(CNC(=O)C/C=C/CCCCC)C1 CC(C)(NC(=O)C1=CN=C(C(N)=O)S1)[C@H1]2CCN(C(=O)C34CCC(F)(CC3)C4)C2 CC[C@H1](C)CC(=O)C(=O)N1C[C@@H1](C(=O)NC2=CN=C(OC)C(C)=C2)CC13CCC3 CN1N=CC(Cl)=C1C(=O)N[C@@]23CC[C@@H1](C2)N(C(=O)C4=CC=CC=C4O)C3 CCCC[C@@H1](O)CCC(=O)NC1(CNC(=O)[C@H1](C)N2C=NN=N2)CCCC1 C#CCCCC(=O)NC1CCCN(C(=O)[C@@H1]2CC3=CC(Cl)=CC=C3O2)CCC1 COCC1=CC=C(C(=O)NC[C@@H1](F)CNC(=O)C(C)(C)CC(F)F)C=C1OC O=C(N[C@@H1]1CCN(C(=O)CCN2C=CC=NC2=O)C1)C3=CSC(Br)=C3 COC1=CC=CC(C(=O)NC[C@@]23CCC[C@@H1]2N(C(=O)CC4CSC4)CCC3)=C1C C[C@H1](NC(=O)[C@@H1](O)CC1=CN=C[NH1]1)[C@@H1]2CCN(C(=O)C(C)(C)C(N)=O)C2 O=C(N=C1C=C(Cl)C=N[NH1]1)N2CCCC[C@H1]2CC3=CC=CC=C3 COC1=CC=CC(NC(=O)[C@H1](C2=CN=C(Cl)S2)N3CCN4N=CN=C4C3)=C1 CC1=CC=NN1CC(=O)N2[C@H1](C(=O)NCCCC3=CC=CC=C3)C[C@H1]4C[C@@H1]42 CC[C@@H1]1[C@@H1](C(=O)N(C)CCCCOC)CCN1C(=O)COCC(=O)OC CC(F)(F)C=1C=C(C(=O)NC2(CNC(=O)C3=CC=NN3CCF)CC2)[NH1]N=1 CO[C@]1(C(F)(F)F)C[C@H1](CN2CCC[C@@H1](C3=CC4=CC=CC=C4[NH1]3)C2)C1 C[C@@H1](C(=O)N1CC[C@@H1](NC(=O)C2=NSN=C2O)C3(CCC3)C1)C(C)(F)F C[C@@H1]1CCN(C2=NC=NC3=C(Br)C=CC=C23)C1 CN(C)C[C@H1](C(=O)N1CC[C@@](CO)(CNC(=O)C=2C=CN(C)C(=O)C=2)C1)N(C)C C[C@@H1]1C[C@@H1](C(=O)N[C@@H1]2C[C@@H1]3C[C@@H1](C(N)=O)C[C@@H1]32)CCC1=O C[C@H1]1CN(C(=O)COC2(C)CCOCC2)CCN1C(=O)C#C[C@@H1]3CCCOC3 CCCCOC1=CC=C(C(=O)N[C@H1]2CCN(C(=O)C3(SCC)CC3)C2(C)C)C=C1 CCCCC(F)(F)C(=O)N1CCC[C@H1]([C@@H1](C)C(=O)N2CC[C@@](C)(O)C2)C1 CO[C@H1](C(=O)N(C)CC1(NC(=O)C2=CN=NC(O)=C2)CC1)[C@H1]3CCOC3 CN(C)[C@@H1](CCO)C(=O)NC[C@@H1](NC(=O)[C@@H1]1[C@H1]2COC[C@H1]21)C3=CC=CC=C3 O=C([C@H1]1CC[C@H1](C2CC2)C1)N3CC[C@H1]4C[C@]4(C(=O)NC5CCOCC5)CC3 CO[C@H1]1C[C@@H1](CC(=O)NCCC(C)(C)NC(=O)[C@@]23CCC[C@]2(C(N)=O)C3)C1 COC1=CC=C2C(=C1)C[C@@H1](C(=O)N3CCC4=NN(C)C(=O)C=C4C3)CO2 CC1(C)CO[C@H1](CC(=O)NCCC2(CNC(=O)[C@H1]3[C@H1]4[C@H1]5C[C@H1]3C(=O)[C@@H1]45)CC2)CO1 CC1CC(CCNC(=O)[C@]2(NC(=O)[C@H1]3CCCCC(=O)C3)CCSC2)C1 CCCCCCCN(C)S(=O)(=O)C1=CC=C(NCC2=CC(C)=C(C)C(C)=C2)N=C1 CC(C)C[C@@H1](CNC(=O)[C@]1(C#N)CCOC1)NC(=O)CN2CCCC2=O COC[C@]1(C)C[C@@H1](NC(=O)C2=CN=CC(O)=C2Cl)CN1C(=O)CCC3=NC=CS3 C[C@@H1](C(=O)NCCC1(CN=C2C=C(C(N)=O)N=C[NH1]2)CC1)N3C=CC=N3 CC1=NN(CCO)C=C1C(=O)N[C@@H1]2CS(=O)(=O)C[C@H1]2NC(=O)COC3(C)CCC3 CC[C@H1](O)C(F)(F)C(=O)N1C[C@@H1](CNC(=O)C2=CN=C(S)N=C2)C3(CC3)C1 COCC[C@H1]1CN(C(=O)C=2SC=NC=2Cl)CCN1C(=O)[C@H1]3CC(=O)N(C(C)C)C3 CC1=NN(CC2=CC=CC=C2Cl)C(Cl)=C1CN(C)CC3CCNCC3 CC1(C)CCN(CCCC=C2N(CC(C)(C)CNC(=O)C=3C=NSN=3)N=N2)CC1 CC1=CC=C(C(=O)N[C@H1](CCN(C)C(=O)[C@@H1]2C[C@H1]2C=3C=N[NH1]C=3)C(C)C)C=N1 O[C@@H1]1CCCC[C@@H1]1CCCN=C2C=CN=C(N3CC4=CC=CN=C4C3)[NH1]2 CCCCC[C@H1](C)CC(=O)NC[C@@](C)(O)CNC(=O)C1=N[NH1]C=C1OC C#CC1(O)CC(C(=O)N(C)C[C@@H1]2CN(C(=O)[C@H1]3CCCC(F)(F)C3)CCO2)C1 C[C@H1](C(=O)NC[C@H1]1C[C@H1](F)CN1C(=O)[C@H1]2CC[C@H1](C3CCC3)CC2)N4C=CN=C4 C=CC[C@@H1](CNC(=O)C1=CC=NC(C)=C1)NC(=O)CCC2=CC=C(Cl)C(Cl)=C2 CCN(CC)CCNC(=O)C[C@@H1](C)N(C)C(=O)C1=CC=C(C)C(O)=C1 O=C(O)C1=CC=C([C@@H1]2CCCN(CC3=CC(Cl)=NC=N3)C2)C=C1 COC(=O)[C@H1]1OC2=CC=C(NC(=O)C[C@@H1]3CCC[C@H1](C4CC4)O3)C=C2NC1=O COCC1(CNC(=O)COC)CCN(C(=O)C2CC3(C2)CC4(CC4)C3)CC1 O=C(COC1=CC=C2C=CC(=O)OC2=C1)N[C@H1]3C[C@@H1]3CNC(=O)C4=CN=CN=C4 CC(C)(C)N1CC[C@@H1](N2CCC(C3=CC=CC=C3Br)CC2)C1=O C#CCO[C@H1](C)C(=O)NCCCC(C)(C)NC(=O)[C@@H1](F)CN(CC)CC CC(C)(C)OC[C@@H1]1CCCN(C(=O)C(=O)N[C@H1]2CC23CCCCCC3)C1 CN1C=NC=C1C(=O)NC[C@@H1]2CN(C(=O)C3(CCO)CC3)CCO2 CC[C@@H1](C)C(=O)C(=O)N[C@@H1]1CCC[C@H1](CC(=O)NCC2=CC(COC)=NO2)C1 CC[C@H1](C)OCC(=O)N[C@@H1](C)CNC(=O)C1=CC=CN2C=CN=C12 CCCC=CC=CCC(=O)N1CC[C@@H1](NC(=O)C2(CO)CC2)[C@@H1](CC)CC1 CC(C)N(CCN(C)C(=O)C1=CC=C2C=C(Cl)C=CC2=C1)C(=O)CC3=COC=N3 O=C(N[C@@H1]1COC[C@@H1]1NC(=O)[C@@H1]2C[C@@H1]3C[C@H1]2CO3)C4=CSC(C5=CC=CC=N5)=N4 N#CC=1C=C[NH1]C(=NCCCCCCNC(=O)CC2=CC=C(F)C(Cl)=C2)N=1 CC1=CC(C)=C(C(=O)NCC[C@@H1]2COCCN2C(=O)CN3N=CN=N3)C(S)=N1 CC=1ON=CC=1C(=O)NCC(=O)N2C[C@@H1](NC(=O)[C@@H1](C)SC(C)C)CC2(C)C COC1(CNC(=O)[C@H1]2C[C@@H1]2C3CN(C(=O)CCN4C=CN=N4)C3)CN(C)C1 C[C@@H1](CCN(C)C(=O)[C@@H1]1CCCC[C@H1]1O)NC(=O)CC2CCC2 CSC1=NC2=NC=NC(NC[C@H1]3CN(C(=O)C4=CC=NO4)CCO3)=C2S1 CCOC[C@H1](O)CNC(=O)[C@H1]1C[C@H1](O)[C@@H1](NC(=O)[C@H1](C)CC(F)F)C1 CC[S@@](=O)C1=CC=CC=C1C(=O)N2CC[C@H1](N(C)C3=NC=NC=C3Br)C2 CC(C)[C@H1](CNC(=O)[C@H1]1CCN(C)C1=O)NC(=O)C2=CN=C(P(C)(C)=O)C=N2 CC=1N=C(O)SC=1C(=O)N2CC[C@](C)(C3=CN(C4=CC=C(Br)N=C4)N=N3)C2 CC(=O)CC1(C(=O)N2CC[C@](C)(CC(=O)N[C@H1](C)CC3=CN=CC=N3)C2)CC1 CC(=CC1=CC=CN=C1)C(=O)N[C@H1](C)C2CN(C(=O)CCS(=O)(=O)N(C)C)C2 C[C@@H1](CCC(=O)N1CC[C@H1](C)N(C(=O)CC2=CC=C(Cl)C(I)=C2)CC1)N(C)C CCCCC[C@@H1](O)CC(=O)N1C[C@H1](NC(=O)C(C)(C)N(C)C)CC2(CCC2)C1 C=C1C[C@@H1](C(=O)NC2=C(Cl)C=CC3=NSN=C23)N(C(=O)CC4=CSC=N4)C1 CCC[C@@H1](C)N(C)CCC(=O)N[C@@H1]1CCN(C(=O)CC2=CC=CC(SC)=C2)C1 CO[C@H1]1C[C@@H1](C(N)=O)N(C(=O)NCCN2C=C(CCCO)N=N2)C1 CO[C@@H1]1CN(C(=O)[C@@H1](SC)C(C)C)C[C@H1]1NC(=O)C2=N[NH1]C=C2C3CC3 CC1=CC(C(=O)N[C@H1](C(=O)NCC=2C=NSC=2)C3CCCC3)=C(C)N1C CC1=CN=CC(CCC(=O)NC(C)(C)CCN(C)C(=O)C2=CC=NN=C2O)=C1 C[C@H1](C(=O)N1CC([C@H1]2CCCN(C(=O)CC[C@H1]3CC3(Cl)Cl)C2)C1)C(F)(F)F C[C@@H1]1CN(C2=NN=C(C#N)S2)CC[C@@H1]1CNC(=O)C=3C=NN(C4=CC=CN=C4)C=3 CC(=O)N[C@H1](C(=O)N[C@@H1](C)C[C@@H1](C)NC(=O)C(C)=CC1CC1)C2=CC=CC=C2 CO[C@@H1](C)C1=NC=C(C(=O)N[C@H1]2C=CCN(C(=O)C(F)(F)C3=CC=CC=C3)C2)S1 CC(C)(C)OC(=O)NOC[C@H1]1OCC[C@H1]1C(=O)NCCCS(=O)(=O)C2=CC=CC=C2 O=C1CC[C@@H1](C(=O)NC23CC(CNC(=O)CO)(C2)C3)O1 C[C@H1]1C(CNC(=O)C2=CON=C2[C@H1](C)NC(=O)C3(C(=O)C4CC4)CC3)[C@@H1]1C COCCCNC(=O)CCC(=O)N[C@@H1]1C[C@H1]2CC[C@@H1]1N2C(=O)CC3(OC)CCC3 C[C@H1](CNC(=O)[C@@H1]1C(F)(F)C12CC2)CN(C)C(=O)C=3SC=CC=3C4CC4 CC[C@@H1](CNC(=O)[C@@H1](C)CSC1=CC=CC=C1)NC(=O)C2=C(C)CCC2 CN(CCN(C)C(=O)C1(N2C=CN=N2)CC1)C(=O)C=C[C@@H1]3CCOC3 O=C(N[C@@H1]1CN(C(=O)CN2CCOCC2=O)CC13CC3)C=4C=C5N(N=4)CCC5 CS(=O)(=O)C1=CC(C(=O)N2CCC[C@@H1]2CNC(=O)C=3C=CSC=3C(F)F)=CO1 CCN1N=C(C(=O)N2CCC[C@@H1]2CN(C)C(=O)CN3N=CN=N3)C=C1O CC=1[NH1]C(=N[C@@H1]2CN(C(=O)[C@H1](O)CC(C)(C)C)CC[C@H1]2C)C=CC=1[N+1](=O)[O-1] CC1=N[NH1]C=C1CNC(=O)CC[C@H1]2CCN(C(=O)C#CC3(C)COC3)C2 C=CCCC[C@H1](NC(=O)CNC(=O)OC)C(=O)N(C)CC(=O)NC COC1=NC=C(C(=O)NC[C@]2(C)CC[C@@H1](NC(=O)C3=CC(C)=CS3)C2)C=N1 CC(C)[C@H1]1C(=O)NCCN1C(=O)C23CC(CO)(CN2C(=O)[C@H1](C)N4C=CN=N4)C3 O=C(C1=CC(Br)=C(F)C=C1N2)CCC3(CC2)CCN(C(=O)[C@H1]4CC4(F)F)CC3 CC1=CSC(=O)N1CCC(=O)O[C@@H1](C)CN2CCC3(CCCC3)CC2 CCN(CCN(CC)C(=O)C1=CN=C(S)N=C1)C(=O)C2=CN=CN2C CC1(C)CCO[C@H1](C(=O)N2C[C@@H1](O)C[C@H1]2C(=O)N[C@]3(C)CCSC3)C1 C=CC[C@H1](CNC(=O)[C@@H1]1C[C@H1]1C=2C=NN(C)C=2)NC(=O)CCOC3CCCC3 C[C@@H1](C(=O)N(C)C[C@H1]1CCCCN1C(=O)C2=N[NH1]C3=CC=CN=C23)N4C=NC=N4 CC1CCC(C(=O)N2CC[C@@H1]([C@@H1](C)NC(=O)CSCC3=CSC(C)=N3)C2)CC1 COC(=O)NCC(=O)NC[C@@H1]1CCCN1C(=O)CC2=CC(Br)=CS2 COC1=CC=C(F)C(C(=O)NC[C@@H1]2CCN2C(=O)C=3C=CSC=3OC)=C1 CCCCCCC(=O)NC[C@@]1(NC(=O)COCC)CCCC[C@H1]1C C=CCCCCCCCC(=O)N[C@H1](CNC(=O)[C@@H1]1C=CCS1)C2CCCCC2 C[C@@H1]1CCN(C(=O)C(=O)NCCNC(=O)C2=CN=C3C=CC=C(Br)C3=C2)C1 C[C@@H1](NC(=O)C=1C=C2N(C=1)CCC2)[C@@H1]3CCCN(C(=O)CC4=CCN(C)CC4)C3 C[C@]1(C(=O)N2C[C@@H1](NC(=O)CCCC3=NC=CS3)CC4(CC4)C2)CCNC1=O CC1=CC(C(=O)N(C)[C@@H1](C)CNC(=O)[C@@H1](C)NC(=O)C2=CC=CO2)=CN=N1 C=C(Br)CC(=O)N1CCC[C@H1](C2CN(C(=O)C3=CC(F)=CC(F)=C3O)C2)C1 COC1=CC=C(C=2N=C(C[C@H1]3C[C@H1](SC)C3)N([C@@H1]4CCS(=O)(=O)C4)N=2)C=N1 COCC[C@@H1](CO)NC(=O)[C@H1](CC(C)C)ONC(=O)C=1C=COC=1C(C)C CC1=NO[C@H1](CC(=O)NCC#CCNC(=O)CC2=CC=C(S(C)(=O)=O)C=C2)C1 COC[C@H1](C)NC(=NC[C@H1](O)CN1CCOCC1)NCC2=NC(C(=O)OC)=CS2 O=C(C1=CC=C(F)C(F)=C1O)N2CC[C@H1]([C@H1]3CCCCN3C(=O)CC(F)(F)F)C2 CO[C@H1](CO)C(=O)N[C@@H1](C)C1CCN(C(=O)[C@H1](C)C2=CC=CC=C2C)CC1 C=CN1N=CC=C1C(=O)N[C@H1]2C[C@@H1](CO)N(C(=O)COC3=CC=CC(Cl)=C3)C2 CCC1=CC=C(C(C)=CC(=O)N2CC[C@@H1]2CNC(=O)[C@@]3(F)CCS(=O)(=O)C3)C=C1 CN1N=C(C(=O)NC2CCN(C(=O)[C@H1]3[C@H1]4[C@@H1]5C[C@@H1]6[C@@H1]7C[C@@H1]([C@@H1]4[C@@H1]75)[C@@H1]63)C2)C=C1C#N O=C(CCN1CCCCCC1)NC[C@@H1]2C[C@H1]3CN(C4=NN=CO4)C[C@@H1]23 CN1C=CC(CC(=O)N2CCO[C@H1](CNC(=O)CCC3=CC=CC(Cl)=C3Cl)C2)=N1 CC[C@H1](C)N1N=CC(C(=O)N2CC(NC(=O)CCC3=CC=CC=C3C)C2)=C1C CN(CCNC(=O)[C@@H1]1C[C@H1]1[N+1](=O)[O-1])C(=O)[C@@H1]2CCC3(CCOCC3)O2 C[C@H1]1CN(C)CCN1C(=O)[C@H1]2COCCN(C(=O)C3=NC=CC=C3C(F)(F)F)C2 COC1(CNC(=O)[C@@H1]2CC[C@H1](CNC(=O)[C@@]34CC[C@@H1](C3)C4(C)C)C2)CCCC1 CNS(=O)(=O)C1=CC=C(C(=O)N2C[C@H1](C)[C@H1](NC(=O)C3=N[NH1]C(C)=C3C)C2)O1 CON=CC(=O)N[C@H1]1CC[C@@H1](CNC(=O)C2=CC3=C(S2)CCCCCC3)C1 CC1=NC(O)=C(Br)C=C1C(=O)N[C@@H1]2CCCN(C(=O)C(F)(F)[C@H1](C)O)CC2 CN1C=C(N)C(C(=O)N[C@@H1]2C[C@H1](CNC(=O)C3(C4CC4)CC3)C[C@H1]2O)=N1 CC[C@H1](C)CC(=O)N1CC[C@H1](CNC(=O)C2=CC=C(C3=NC=NN3C)C=C2)C1 C=C1CC(COC)(C(=O)N[C@@H1](CNC(=O)CCSCC)C2=CC=C(OC)C=C2)C1 CCN1C=CC(CC(=O)NCC(C)(C)C#CC(=O)N2C[C@H1]3CC=C[C@H1]2C3)=N1 CCN(C[C@@H1](C)NC(=O)C1=CC=NC(O)=C1)C(=O)C2=NN(C)C=C2S(N)(=O)=O CN(C[C@@](C)(O)C1CCCCC1)C(=O)NCC2=CC=NC=N2 CON1CCC(C(=O)N2CCC(CCC(=O)NC[C@@H1](C)C(C)(F)F)CC2)CC1 C[C@H1](NC(=O)C1=CN=C[NH1]1)[C@@H1](C)NC(=O)C2=CC=CC3=NC=C(Br)N23 C=CCCN=C(NC[C@@H1](OC)C1=CC=C(OC)C=C1)NC[C@@H1]2COC(C)(C)C2 CCC(CC)(CNC(=O)[C@@H1](O)CN1C=NC=N1)NC(=O)C2=CC=NC(SCC)=C2 CC(C)CO[C@@H1](C)C(=O)N1CCCN(C(=O)CCC2=CN=CO2)C[C@H1]1CO C[C@@H1](CCNC(=O)[C@@H1]1CCC2=CC=NN2C1)NC(=O)CO[C@H1]3CCC[C@H1](C)C3 CC1=CC=C(C(=O)NCC2(C)CCN(C(=O)C3=NN=C(O)N=C3O)CC2)C=C1C CC(C)CC1=NC(C(=O)N2C[C@H1]3[C@@H1](NC(=O)[C@@H1](C)C4=CC=NN4C)C[C@H1]3C2)=CS1 CCCC1=N[NH1]C=C1C(=O)N2CCC[C@@H1]([C@@H1]3CCCN(C(=O)[C@H1](C)N(C)C)C3)C2 CCCCCC(C)(C)CNC(=O)/C=C/CC(C)(C)NC(=O)CC1=CC(CC)=NO1 O=C(N1CC([C@H1](O)C(=O)N2CC3(COCC(=O)N3)C2)C1)C=4C=C5N(N=4)CCC5 C[C@]1(CNC(=O)[C@]2(C)CC2(F)F)CN(C(=O)C3CS(=O)(=O)C3)CCO1 CCOC(OCC)C(=O)NC[C@H1]1C[C@@H1](O)CN1C(=O)C[C@H1]2C[C@H1]3CC[C@H1]2C3 C[C@H1](NC(=O)C1=CC=CC2=CN=CC=C12)[C@H1]3CCCN3C(=O)[C@@H1]4[C@H1]5CCC(=O)[C@@H1]54 CC=1C=C(C(=O)N2CC([C@H1](C)NC(=O)C3=CC(C)=NC4=C3C(C)=NN4C)C2)ON=1 C=CC1(C(=O)NCC=2N=CSN=2)CCN(C(=O)C3=N[NH1]C=C3CC)CC1 COC1(C(=O)N2C[C@]3(CNC(=O)C4=CC=CC(F)=C4)CC[C@H1]2C3)CCCCCC1 CC1=NOC(N)=C1C(=O)N2CC[C@@](O)([C@@H1](C)NC(=O)C[C@H1]3CN4CCN3CC4)C2 C=CCCCCC(=O)N(C)CCOCCN(C)C(=O)CC1=CC(O)=NC(O)=N1 CC[C@](C)(CNC(=O)[C@@H1](CNC(=O)CNC1=NC=CC=N1)CC)COC CCN(CCNC(=O)[C@H1](C)C1=CN=CC(F)=C1)C(=O)C2=CC(C)=CC(C)=N2 CC(C)(OCC(=O)N[C@@H1]1CC[C@H1]1CNC(=O)CCC2CC2)C(F)(F)F CC[C@H1](C)C1=CSC(=N[C@H1](C)C2=CC=C(O)C(C(N)=O)=C2)[NH1]1 CC[C@@H1](CN(CC)C(=O)C1CS(=O)(=O)C1)NC(=O)C2=NC=NC3=C2OCCO3 CCCC=C[C@H1](O)C(=O)N1CCCC[C@@H1]1CN(C)C(=O)C=2C=NN(CCO)C=2N CC1=NC=CN1CC(=O)NC[C@@](F)(C(=O)N2CCC23CCCC3)C(C)C C[C@H1]1CC[C@@H1]1C(=O)N(C)CCCCC(=O)NCCN2C=NC=CC2=O CSC1=CC=C(C(=O)N2C[C@@H1]3COC[C@]3(C(=O)NCC=4SC=CC=4C)C2)S1 CN1CC[C@H1](NC(=O)CCCN2C=CN=N2)[C@]13CCCN(C(=O)[C@@H1]4C[C@H1]4C)C3 COCCCC(=O)N1C[C@@]23CCC[C@@]2(C1)CN(C(=O)C=4C(C)=NOC=4C)C3 CC[C@@](C)(C(N)=O)C(=O)N1CCC(C(C)(C)NC(=O)[C@H1]2C(Cl)(Cl)C23CC3)CC1 CC1=CC=C2C(CC(=O)N[C@@H1]3CC[C@@H1]3NC(=O)C[C@@H1]4C=CCC4)=COC2=C1 C[C@@H1]1C[C@@H1](NC(=O)CCC(F)F)CN1C(=O)[C@@H1]2CC(=O)N(C3CCCCCC3)C2 CN1CCC[C@@H1]1/C=C/C(=O)N2CC[C@@H1](C3CC3)[C@H1]2CNC(=O)CC4=CC=CO4 CCN(CC)[C@@H1](C)CNC(=O)C[C@@H1](CNC(=O)C(C)(C)[C@@H1](C)O)C1CCC1 CC(C)CCC(=O)N1CCN(C(=O)C2=CC(C#N)=C(O)N=C2N)[C@@H1](C3CC3)C1 C#CC1=CC=CC(CC(=O)NC2(CNC(=O)[C@H1]3CCCCS3(=O)=O)CCC2)=C1 CCC1=CC=C(C(=O)NCC=2OC=NC=2C(=O)NC3(C4=CC=CS4)CC3)S1 C=CCC(=O)N[C@H1](CNC(=O)C1=CC(C)=CC(C)=C1)CC(C)C CCCN(CCNC(=O)C1=CC=CC2=C1CCC2)C(=O)C3CC4(CCC4)C3 CC[C@@H1]1CN(C(=O)CCCNC(=O)CN(C)C)C[C@@H1]1O COC1=CN=CC(CCC(=O)N[C@@H1]2CCN(C(=O)[C@@H1](O)CCN(C)C)C23CC3)=C1 CC[C@](C)(C(N)=O)C(=O)NC[C@@H1](O)CNC(=O)C1=C(C)N(C)C2=CC=CC=C12 CC1=CC=C(C(=O)N(C)CC2CN(C(=O)C3(N4C=CC=N4)CCC3)C2)N=C1 CS[C@@H1](C)C(=O)N[C@H1]1[C@@H1]2C[C@H1]1N(C(=O)C3=CC(F)=CC=4N=C[NH1]C3=4)C2 COC(=O)C1=CN=C(C)C=C1N2C[C@@H1]3C(CNC(=O)C[C@H1](C)C4CC4)[C@H1]3C2 CC1=CSC(CCCNS(=O)(=O)C2=CC(C)=C(C)C=C2C=3C=NOC=3)=N1 O=C(NC/C=C/CNC(=O)[C@H1]1C[C@@H1](O)C1)[C@@]23CC[C@H1]2S(=O)(=O)C3 CN(C1CC(O)C1)S(=O)(=O)C2=CC=C(NCC3CC4(CCC4)C3)C(F)=C2 CC=CC=CC(=O)N[C@@H1]1C[C@H1](O)CN(C(=O)CC2(CC)CCC2)C1 CCC1=CC(C(=O)N2CC[C@H1](C)[C@H1]2C(=O)N[C@@H1](C)CNC(=O)OC)=N[NH1]1 CC(C)CC(C)(C)C(=O)N[C@@H1]1CCC[C@H1](CNC(=O)CC(C(C)C)C(C)C)C1 COC1=CC(C(=O)N2CC[C@](CF)(NC(=O)C[C@H1]3CCC(F)(F)C3)C2)=NC=N1 CO[C@@H1]1[C@@H1](NC(=O)/C=C/CNC(=O)CNC(N)=O)C[C@H1]1O CC1=C(N2C[C@H1](C)[C@@H1](CO)C2)N=CN=C1N[C@@H1]3CCCN(C)C3=O CN(C(=O)NC1CC(C2=NC=C[NH1]2)C1)[C@@H1](C3=CC4=CC=CC=C4O3)C5CC5 CN1C=NN=C1CCNC(=O)[C@H1]2CN(C(=O)CCC(=O)C3CC3)CC2(F)F C[C@@H1](CCC(=O)N(C)CCN1CCN(C(=O)CC2=CC=CO2)CC1)N(C)C O=C(N[C@H1]1CCCC12CN(C(=O)C3=CC=NC=N3)C2)C4=CC5=C(N=N4)OCCS5 O=C(N[C@H1]1[C@H1]2[C@@H1](O)C[C@@H1]1CN2C(=O)CN3CCCC3=O)[C@@H1]4CCC5(CCC5)C4 CCN1CCN(C(=O)N(CC2=NC=CO2)C3=CC=CC(F)=N3)C[C@H1]1C CS(C)(=O)=NCC(=O)NC[C@@H1]1CN(C(=O)C2=CSC(C3CCCCC3)=N2)CCO1 CCC1=NO[C@H1](CC(=O)N2CCCCCC[C@H1]2C(=O)N[C@H1](C)C=3SC=NC=3C)C1 CC1=C(Cl)C=CC=C1C(=O)N[C@H1](C)CN(C)C(=O)C(C)CC2CC2 CSCC(C)(C)C(=O)NC[C@H1](C)N(C)[C@H1](C)C(=O)NC1=CC=C(Cl)C=C1C C[C@@H1]1CCC=2N=C(N3CCN(CCN(C)C)C3)[NH1]C(=NCCSC(F)(F)F)C=2C1 CCNS(=O)(=O)C1=CC=C(C(=O)N(C)CC[C@H1](C)NC(=O)CC2=CCCC2)C=C1 CC1=CC=C(C(=O)N2C[C@@H1]3C[C@H1](C2)CN3C(=O)[C@@H1]4CC(C5=CC=CC=C5)=NO4)S1 CCC1=C(C(=O)N(C)C2=CC=CC(OC(F)(F)F)=C2)C=NN1C3CCCC3 C=C[C@](C)(CC)C(=O)NCC1CC(NC(=O)C2=CC=NC(OC)=C2)C1 C#CCCN=C(NCC1=CC=C(N2C=CC(C)=N2)N=C1)N3CCS[C@@H1](CC)C3 C[C@@H1]1C[C@H1](C(=O)N[C@H1]2C=CC[C@H1](C(=O)NCCC3=CC=CN=C3)C2)CCO1 C=C[C@@H1]1C[C@H1]1C(=O)N[C@]2(C)C[C@H1](NC(=O)[C@@H1](CC(=O)OC)N3C=NC(C)=C3)C2 CO[C@@H1](CC1CC1)C(=O)N[C@@H1](CCCNC(=O)CC2=CSC=N2)C3=CC=CC=C3 CC(=O)C1=C(C)[NH1]C(C(=O)NC[C@@H1]2C[C@H1]2NC(=O)C(C)(C)CC(C)(C)C)=C1C CCOC1=CC=C(C(=O)NC[C@H1]2CCN(C(=O)[C@H1](C)[C@H1](C)O)C23CC3)C=N1 COC1=CC([C@@H1](C)NC(=O)N(C)C2=CC=C(C)C(Br)=C2)=CC=C1OCC#N C#CC1=CC=C(CCC(=O)N2C[C@@H1](O)[C@H1](CNC(=O)C(C)(C)S(C)(=O)=O)C2)C=C1 O=C(C1=CC=CC(F)=C1)N2CCC[C@@H1]([C@@H1]3CCN(C(=O)C4(O)CCCC4)C3)C2 CCC1=NC(C)=C(C(=O)NC2=CC=C(OCCN)C(Cl)=C2)O1 C=C(Br)CCC(=O)NC[C@@H1]1CCN(C(=O)[C@@]2(C#N)C[C@@H1]3C[C@@H1]3C2)C1 C[C@H1](C(=O)N1CC([C@H1]2CCCN(C(=O)C3CCC3)C2)C1)C4=CC=C(O)C=C4 CN1C=C(C(=O)N[C@@H1]2CCC[C@@H1]2CNC(=O)[C@@H1]3CCC[C@H1](F)C3)C(C(C)(C)C)=N1 COC1=NC=C(Cl)C=C1C(=O)N2CCC3(CCN(C(=O)[C@H1]4SCC[C@H1]4C)CC3)C2 CC1=CC=C(C(C)(C)C(=O)N2CC(O)([C@@H1](C)NC(=O)CCC3CCCC3)C2)C=C1 CC1=CC=C(C(=O)NC23C[C@@H1]4C[C@H1](C2)CC(NC(=O)CCF)(C4)C3)C([N+1](=O)[O-1])=C1 CC=CC(=O)N1CCC[C@H1](NC(=O)C2=CC=C(SC3=CC=CC=C3)C=C2)[C@H1](F)C1 CN1N=CC=C1C(=O)N[C@@H1]2C[C@H1]3C[C@H1](NC(=O)C(F)(F)C(C)(C)O)C[C@H1]3C2 COC(=O)C1=CN=C(N2CCC(CCNC(=O)[C@]3(C)CCCCO3)CC2)N=C1 CCC1(C#CC(=O)NC2(C(=O)N3CCN4CC[C@H1]3C4)CC(F)(F)C2)COC1 CN1C=CC2=CC(C(=O)NC3CC(NC(=O)[C@@H1]4CC4(C)C)C5(CCC5)C3)=CN=C21 C[C@H1]1CC[C@@H1](CNC(=O)C2=CC(O)=CC(N)=C2Cl)CN1C(=O)C3CS(=O)(=O)C3 COC[C@@]1(C(=O)N[C@H1]2CN(C(=O)C(N)=O)CC(C)(C)C2)CCOC1 C=CC[C@]1(C(=O)N2CCNC(=O)[C@@H1]2C)CCN(C(=O)[C@@H1](C)N3C=C(C)C=N3)C1 CC1=NC(C(=O)N[C@@H1]2C[C@@H1](O)[C@@H1](CNC(=O)[C@@H1](C)SC(C)C)C2)=CO1 CCC[C@H1](OCC)C(=O)N(C)CCCC(=O)N1C[C@H1]2C[C@@H1]1[C@@H1]3C[C@H1]23 CC(C)C[C@@H1](C)C(=O)N[C@]1(CO)CCN(C(=O)C2=CC=3OC(Br)=CC=3[NH1]2)C1 CC1(C(=O)N2CC3(CO[C@H1](CNC(=O)CN4N=CC=CC4=O)C3)C2)CSC1 CCC[C@@H1](C#N)C(=O)N(C)CCCCN(C)C(=O)CC1=CSC(Br)=N1 CN(CCOCCNC(=O)[C@H1]1CCS1(=O)=O)C(=O)C=2C=C3N(N=2)CCNC3=O CC(=CN1C=CN=N1)C(=O)N[C@H1](CNC(=O)[C@@H1](F)C[C@@H1]2CCOC2)C3CC3 C#CC1(C(=O)N[C@@H1](CC)CN2C=NC=N2)CN(C(=O)C[C@H1](C)CC(C)(C)C)C1 CCC1=NC=C(C(=O)N(C)[C@H1]2CC[C@@H1](NC(=O)C3=CC=CC=C3NC(N)=O)C2)[NH1]1 CC1=NN(C)C=C1CC(=O)N2CCC[C@@](C)(C(=O)NCC3CC4(CC[C@H1]4O)C3)C2 COC(=O)[C@H1]1C[C@H1](C(=O)NCC2(CNC(=O)CC(C)(C)C)CCC2)C13CCCC3 C[C@@H1](CC(=O)N[C@@H1]1CC[C@H1](NC(=O)C2(C)CCCCC2)C1)CN(C)C O=C(NC[C@H1]1C[C@H1]2C[C@@H1](C1)N(C(=O)C=CCF)C2)C3=NC=CC(C(F)F)=N3 CCC1=CC(C(=O)N[C@H1]2CCC[C@]2(C)NC(=O)C3=NC=CC=4OC=CC3=4)=CC=N1 C[C@]12CC[C@H1]1CN(C(=O)[C@@]34CCN(C(=O)C5=CN6C=CC=CC6=N5)C[C@@H1]3C4)C2 C[C@@H1](O)C1=CC=CC(NC(=O)C2=CC3=C(S2)CCN(C(=O)[C@@H1]4CC(=O)N4)C3)=C1 C[C@@H1](CNC(=O)CCCC(F)(F)CO)NC(=O)C[C@@]1(C)CC1(Cl)Cl C#CC1(C(=O)N2CC3CC2(C(=O)N[C@@H1](C)[C@@H1]4CCCCO4)C3)CCCCC1 COC(=O)[C@@H1]1CC[C@]1(C)C(=O)N(C)C[C@H1]2CCCN(C(=O)[C@H1]3C[C@@H1]3C)C2 CCOCCC1(C(=O)NC[C@@H1]2C=CCN2C(=O)C=CC3=NC(C)=C(C)[NH1]3)CCC1 CCCN(CCNC(=O)CCN(C)C(C)=O)C(=O)C1=CC=C(Br)C=2C=N[NH1]C1=2 C=CCC1=CC=CC=C1C(=O)N[C@H1]2C[C@H1](NC(=O)[C@@]3(C)CCO[C@@H1]3C)C2 CC(=O)C1=C(Cl)N=CN=C1N2C[C@H1]3C[C@H1](NC(=O)CC(C)(C)O)C[C@H1]3C2 COCCN(CC1=CC=CO1)C(=O)C(=O)NCC(C)(C)C2=CC=CN=C2 C[C@H1]1CCN(C(=O)CCC2=CC(Cl)=CS2)[C@H1]1C3=CN(CC4CC4)N=N3 O=C(NC[C@@H1]1CCCC2(CN(C(=O)C3=CC4=CC=CN4C=N3)C2)O1)C5=COC=N5 CC[C@H1](CO)C(=O)N[C@@H1]1CCCC[C@H1]1NC(=O)/C=C/C2=CC=CC(F)=C2F C#CC[C@@](C)(CC)C(=O)NCCCN(C)C(=O)C1=CN=C2SC=CC2=C1 CN(CC1=CC=C2C(F)=CC=C(Br)C2=N1)[C@]34COC[C@H1]3C4 CCC[C@H1](C(=O)NCC[C@H1]1C[C@H1](NC(=O)C2(C(C)(C)OC)CC2)C1)C(=O)OC COC(=O)C1CCC(OC(=O)C2=CN3C=C(Cl)C=NC3=N2)C1 CC(C)(C)OC(=O)N1CCO[C@@H1](C(=O)NC[C@H1](O)CNC(=O)C23CC(C2)C3)CC1 O=C(NCCCC1=NC(C(F)(F)F)=CS1)NNC(=O)C2=CC=C3N=N[NH1]C3=C2 CC(C)NC(=O)[C@@H1](C1=CC(C2=CC=CC=C2)=CO1)N3CC[C@@H1](OC(=O)N(C)C)C3 COCCN(CCNC(=O)CCC[N+1](=O)[O-1])C(=O)[C@H1]1C[C@@H1]1[C@@H1]2C[C@H1]2C CCN(CC)C(=O)CCCN=C(NCC1=CC=NN1C)NCC2(OC)CCCC2 CC1(C)C[C@H1](C(=O)N[C@@H1]2CCC[C@H1]2CNC(=O)[C@@H1]3CCC(=O)O3)CCO1 CC1=CC=C([C@H1](C)NC2=CC=C(C(C)(C)C#N)C=N2)C=C1F CCCC[C@H1](C)C(=O)N1CC(SC)(C(=O)NCCC2=CC=C(C)S2)C1 CC(C)N(CC(=O)N[C@H1](C)C1CCCCC1)C(=O)[C@H1]2COC(=O)N2C CSC[C@H1](O)C(=O)N1CCO[C@H1](C(=O)NC2CC3(COCCO3)C2)C1 CC[C@H1](C)OCC(=O)N[C@H1](C)CN1C=C2C=NN=C(CC(F)(F)F)N2C=N1 COC1=CC=CC(C(=O)NC[C@H1]2CN(C(=O)C=3C=C(C)ON=3)CCO2)=C1[N+1](=O)[O-1] CC1=CC2=CC=CC=C2N1CC(=O)N[C@H1](C)CN(C)C(=O)C3=CC=C([N+1](=O)[O-1])[NH1]3 CN1C[C@@H1](O)C[C@H1]1C(=O)N[C@@](C)(C(=O)NCCC(C)(C)O)C2CCC2 O=C(NC[C@@H1]1C[C@H1]2C=C[C@H1]1C2)[C@@H1]3[C@H1]4CN(C(=O)C5(Br)CC5)C[C@H1]43 CC1=CC=C(F)C(C=2C=NC3=NC=C(C(=O)NC4=NC=CC(I)=N4)N3C=2C)=C1O CCN1C(C)=NN(CC(=O)N2CC[C@H1](CN(C)CC(=O)NCC#N)C2)C1=O CC1=CSC(CC(=O)NC2[C@H1]3CCC[C@H1]2CC(NC(=O)C4=COC(C)=C4)C3)=C1 CO[C@H1](CCS(C)(=O)=O)C(=O)NCC1(C(N)=O)CN(C(=O)C2=CC=CN=C2C)C1 NC1=CC=C(Cl)C=C1C(=O)NC23CCC(CC2)N(C(=O)C4(F)[C@@H1]5CCCC[C@H1]54)C3 C=CCC1=CC=CC=C1C(=O)N[C@@H1]2C[C@H1]3CC[C@@H1]2CN(C(=O)[C@H1](C)C(F)(F)F)C3 C[C@@H1](C(=O)N[C@@H1]1CC[C@@H1]1CNC(=O)C2=CC=C(N=NC(N)=O)C=C2)N3C=NC=N3 C#CCNC(=O)CC(=O)N1C[C@@H1](NC(=O)C=2OC=NC=2C(F)(F)F)C[C@@H1]1C CC1=NN2C(=C1C(=O)N[C@@H1]3CCC[C@H1]3NC(=O)C[C@@H1]4CC(C)(C)CO4)CCCC2 CC(C)CSCC(=O)NC/C=C/CNC(=O)CN1CC=CC1 CC(C)CNC(=O)[C@@H1](C1CC(C)(C)OC(C)(C)C1)N2CC[C@@H1](OCCF)C2 CC1=CC=C2C(=C1)C[C@H1](C(=O)OCC=3C=C(Br)N(C)N=3)S2 CSCC(C)(C)C(=O)N1CC[C@](C)(CNC(=O)C2=CN=C3C(=C2)N=C(O)N3C)C1 CCC=1N=C(C)SC=1C(=O)N2CCN(S(=O)(=O)C3=CC(Br)=CC=C3C)[C@@H1](C)C2 COC1=NSC=C1C(=O)N2C[C@@H1](NC(=O)C3=CN=CC(SC)=C3)C[C@@H1]2C O=[N+1]([O-1])C1=CC=C(S(=O)(=O)NC[C@@H1]2CNCCO2)C=C1F COC1=CC(C)=CC=C1C(=O)N2CCN(C(=O)[C@@H1]3C[C@]3(C)Br)C[C@@H1](O)C2 CC1=CC=C2C(C(=O)NC34CC(CNC(=O)[C@H1](C)C(C)C)(C3)O[C@@H1]4C)=C[NH1]C2=C1 CC=CCCC(=O)NC(C)(C)CNC(=O)C1=CN=C2C(=C1N)CCCC2 CCCN(C(=O)[C@@H1]1CC[C@H1](CNC(=O)C[C@@H1](O)C(C)C)C1)C(C)C CC(C)CC(=O)N1CC(CCO)(NC(=O)C2=CC(Br)=C(F)C=C2O)C1 CCCCN1N=NN=C1C2(N[C@@H1](C)C3=CC=CC(CC(F)(F)F)=C3)CCCC2 CC=C(CC)C(=O)NC1([C@H1]2CCN(C(=O)[C@@H1]3[C@H1](C)[C@H1]3OCC)C2)CC1 CC[C@H1](C)[C@H1](C)C(=O)NC[C@H1]1CC[C@H1](NC(=O)C2=CSC(Cl)=N2)CC1 CC1=NC(=N)[NH1]C=C1C(=O)N[C@@H1](C)C[C@H1](C)NC(=O)C2=CC(Cl)=NC=C2F C=CC[C@@H1](CC(C)C)C(=O)N1C[C@H1]2C[C@@H1]1[C@H1]2NC(=O)C=3C=C[NH1]C=3C(C)C CC1=CC(Cl)=NC=C1C(=O)N[C@@H1]2C[C@H1]3C[C@@H1]2CN3C(=O)C=4C(C)=NN(C)C=4C C[C@H1]1CN(C(=O)CC2=CN=C(C3CC3)[NH1]2)C[C@@H1](C)CN1C(=O)CN4C=CC=N4 COC(=O)C1(C(=O)NC[C@@H1](NC(=O)[C@H1](O)CCSC)C2CC2)CC1 C[C@H1]1CCCC2=NC=C(C(=O)N[C@@H1]3CCCN(C(=O)[C@@H1]4C5C[C@@H1]6C4[C@@H1]6C5)C3)N21 N#CC=1N=CN(CC(=O)N2CC[C@H1](CNC(=O)[C@@H1]3CCCN(C(N)=O)C3)C2)N=1 CCO[C@H1](C(=O)NC(C)(C)CN1CCN(C(=O)[C@@H1](F)C(F)(F)F)CC1)C2CCC2 CC1=CC(=NCC=2N=COC=2C)[NH1]C(N3CCN(C4=NC(=N)[NH1][NH1]4)CC3)=N1 O=CCSC[C@@H1]C(=O)N1CC[C@]2(CC[C@@H1](NC(=O)[C@@H1]3C=CCS3)C2)C1N C[C@@H1](O)CC(=O)N1CCC[C@H1]1C2(NC(=O)C3CCC=CCC3)CC2 CC(C)C1=NC=CN1CC(=O)N[C@@H1]2C[C@H1](F)CN(C(=O)CCNS(C)(=O)=O)C2 CC1=CC(C2=CN=CN=C2C(=O)N(CCS(=O)(=O)O)CC(N)=O)=N[NH1]1 CC(C)NC(=O)C(=O)NCC1=CCN(C(=O)[C@@H1](C)CSC2=CC=C(F)C=C2)CC1 CCN(C)C1=CC=C(C(=O)N[C@H1](C)[C@@H1]2CCCN2C(=O)/C=C/[C@@H1]3CCCO3)C=C1 C[C@@H1](N1C=C([C@H1]2CCN(C(=O)C3=CN=CC=C3Br)C2)N=N1)C45CC(CO4)C5 CC1=CC=C(C(=O)N2CC3(CCCC3)[C@H1]2C(=O)NCC(C)(C)C(F)(F)F)N1C CC1(C)[C@H1]2CC[C@]1(C(=O)N3C[C@H1](CO)C4(C3)CN(C(=O)[C@H1](O)C(F)(F)F)C4)CC2 CC(C)[C@H1](C)C(=O)N1CCC(CN(C)C(=O)C2CN(C(C)C)C2)CC1 CC(C)(/C=C/C(=O)NC[C@@H1]1C[C@@]12CCOC2)NC(=O)[C@H1](O)CN3C=NC=N3 C[C@@H1]1CCC[C@H1]1C(=O)NC[C@]2(C)CN(C(=O)C3=CC=CC=C3[N+1](=O)[O-1])CCO2 CCCN1N=NN=C1[C@]2(NCC3=CC=NC=C3Cl)CCC[C@@H1]2CC CCCC[C@@H1](N)CC(=O)N1C[C@@H1]2CCN(C(=O)NC3=CC=CC=C3)[C@H1]2C1 CC1=CN=CC(CCNC(=O)COCCNC(=O)[C@]2(C)CCCOC2)=N1 CCOCCC1(C(=O)N2CCC[C@H1]2CNC(=O)[C@]3(F)C[C@H1]3C)CCCC1 CC1=CC=C2N=CC=CC2=C1NC(=O)C(=O)NCC3=CC=C(N(C)C)C(C)=C3 C[C@@H1]1OCC[C@H1]1CC(=O)NC[C@@H1]2C[C@H1]2CNC(=O)C3=CC=C4OC=NC4=C3 C=CCN(CCC(=O)NC[C@@H1]1[C@H1](CO)C1(C)C)C(=O)[C@H1](C)CC#N COC[C@](C)(NC(=O)C1=NC(C2CC2)=CS1)C(=O)OC CCN(CC)S(=O)(=O)CC(=O)NC(C)(C)[C@H1]1CCN(C(=O)[C@@H1]2CCO2)C1 CC=1N=C2N(N=1)CCN(C3=NC(=NCC4=CC=NN4C)[NH1]C=5C=C[NH1]C3=5)C2 COC1=CN=CC=C1C(=O)NC2(C3CN(C(=O)C=4C=COC=4Br)C3)CC2 COC1(OC)CC(C)(C(=O)NC[C@@H1](O)CNC(=O)C2CC2)C1 CN1CCC[C@H1]1CCC2=CC(C(=O)N3CC4(C[C@@H1]4C(=O)N=C5C=C[NH1][NH1]5)C3)=CC=N2 CC[C@H1](C(=O)NC1=CC=CC(CNC(=O)CCC=2C=C[NH1]N=2)=C1)[C@H1](C)O C=C(Cl)CCC(=O)N(C)[C@H1]1CCC[C@@H1](N(C)C(=O)C2=CC=C(O)C=N2)C1 O=C1C[C@H1](C(=O)N2C[C@H1]3CNC[C@H1]3C2)N(C(=O)[C@@H1]4COC(=O)N4)C1 C#CC[C@@]1(C(=O)N2CC[C@@H1]2C=C)CCN(C(=O)[C@H1]3C[C@@H1](C)N(C)C3)C1 CC1=C(C)C[C@](C)(C(=O)N2CC(O)(CCNC(=O)[C@H1]3C[C@@H1](O)C3)C2)CC1 C#CC[C@H1](C(=O)N1C[C@@H1](OC)C[C@@H1](NC(=O)C2(OC(C)C)CCC2)C1)C3CC3 CCCC[C@H1](O)CCC(=O)N1CCC[C@@H1](C)[C@H1]1CN=C2C=C(C)N=C(OC)[NH1]2 CCN(CCCNC(=O)C[C@H1](C)NC(=O)C1CCCC1)C(=O)C2=NC(=O)N(C)[NH1]2 CCC1=CC=C(C(=O)N[C@H1]2CN(C(=O)C3(C)CC=CC3)CC2(C)C)C(N)=C1 COCCC(C)(C)CC(=O)N1CC[C@@H1](OCC(=O)NCC=2C=N[NH1]C=2)C1 C#CC[C@H1](C(=O)NCCN(C(=O)C1=C(C)C=CC(N)=C1C)C2CC2)C3CC3 C/C=C/CCCCC(=O)N1CC(COC)(C(=O)NC[C@@](C)(O)C(F)F)C1 C[C@H1](CCN(C)C(=O)C1=CC2=CC=CN2C=N1)NC(=O)[C@@H1]3CCC3(C)C C[C@@H1](OC(=O)CC1=CC=CC=C1N2CCCC2=O)C3=CC=CC=N3 C=C[C@@H1](O)C(=O)N1C[C@H1](NC(=O)C2=CC3=C(C)C=C(Cl)C=C3[NH1]2)C(C)(C)C1 CCCC[C@H1]1CN(C(=O)[C@@H1](O)C2=CC=C(C3CC3)C=C2)CCN1C(=O)C(C)(C)F CCSC1CN(C(=O)[C@@](C)(NCCCF)N(CCCOC)C(=O)OC(C)(C)C)C1 CC1=CC([C@@H1]2CCCN(C(=O)COC(=O)C3=C[NH1]N=C3OCC(F)F)C2)=N[NH1]1 CN1C=NC=C1CC(=O)N[C@H1]2C[C@H1]3CC[C@@H1]2N3C(=O)C[C@H1]4CC=CCC4 C#CCCC[C@H1](C)C(=O)N(C)[C@@H1]1CCCN(C(=O)C2=NC=C(C#N)C=C2C)CC1 CC1CN([C@H1](C)C(=O)N[C@@H1](C)CCC(=O)N2CC(N3CC(F)C3)C2)C1 CC1=NC=CC(Cl)=C1C(=O)NC[C@@]2(O)CCN(C(=O)COC=3C=CON=3)C2 O=C1NCCN(C(=O)C2=CC=C(O)C([N+1](=O)[O-1])=C2)[C@H1]1C3CC3 COC1=CC(C(=O)NC[C@H1]2CCC23CCN(C(=O)C(C)(C)CF)CC3)=CC=C1Cl OCCC1=NNC(=NCCC2=CC=C3N=CSC3=C2)[NH1]1 C[C@H1]1CCN(C2=CC(Cl)=CC=C2[N+1](=O)[O-1])C[C@@H1]1NC(=O)CSCC(N)=O CSCC1(CC(=O)N2CC[C@H1](C(=O)N[C@H1](C)C=3C=NN(C)C=3)C24CCC4)CC1 CCCC[C@H1](NC(=O)[C@@H1](C)OCCCC)C(=O)NCC1=NC=C(C)[NH1]1 O=C(N[C@H1]1CCN(CC2=CC=C(C3=CC=C(Br)C=C3)C=C2O)C1)C4=CC(Br)=CS4 CC[C@@H1](OC1=CC=CC(C)=C1)C(=O)N[C@H1]2C[C@H1](NC(=O)C3=NC(=N)C=C[NH1]3)C2 C[C@H1](NC(=O)C1=CC=NN1C2CCC2)[C@H1]3CCCN(C(=O)C4CCCCCC4)C3 COC(=O)[C@@](C)(CO)NC(=O)CCOCCNC(=O)[C@@H1]1CCC(C)(C)OC1 O=C(N[C@@H1]1CCN(C(=O)CC2=CC(F)=CC(F)=C2)C[C@H1]1F)[C@H1]3CC4CC3C4 COC[C@@H1](O)C(=O)NC1(C)CN(C(=O)CCC=2C(C)=NOC=2Cl)C1 N#CCCN=C1[NH1]C2=C(C(=NCC3=CC(F)=C(Br)C=C3F)[NH1]1)SCC2 CCN1C=CN=C1C(=O)NC2(CCC(=O)N[C@@H1]3C[C@H1]4C[C@H1]3[C@H1](O)[C@@H1]4O)CCCC2 CCC1=CC=C(F)C=C1C(=O)N[C@H1](CNC(=O)C2=CC=CC=C2C(C)C)C(C)C CN(C(=O)C[C@H1]1C=CCC1)C2(CC(=O)NC3(CC(C)(C)C)CC3)CC2 C[C@H1]1[C@H1](NC(=O)CSCC2=NC=C[NH1]2)[C@H1](C)CCN1C(=O)[C@H1]3COCCO3 C[C@@H1]1C[C@H1](C(=O)N2CCN(C(=O)C3=CC=CC(O)=C3Cl)C4(CC4)C2)[C@@H1](C)O1 COC(=O)C[C@H1](C)C(=O)N(C)CCOCCNC(=O)C1=CC=CC(Cl)=C1F CN(CC1CN(C(=O)[C@H1]2CC[C@@H1](N(C)C)CC2)C1)C(=O)CC=3C=CSC=3Cl CCCCN1N=CC=C1C(=O)NCC[C@H1](O)CNC(=O)C=2ON=C(CC)C=2C CN(C)CC(C)(C)CC(=O)N1C[C@H1]2C[C@@]2(C(=O)N3CC(C)(C)[C@@H1]3C4CC4)C1 CC=1SC(C(F)(F)F)=NC=1C(=O)N[C@@H1]2CCCN(C(=O)CNC=O)C[C@@H1]2F C[C@H1](NC(=O)C1CCCC1)C(=O)NCCC2CN(C(=O)C3=CN=C(Cl)C(N)=C3)C2 COCCC1CCN(C(=O)C[C@@H1](NC(=O)CN2C=C(CO)N=N2)C(C)C)CC1 O=C(C(=O)N1CC[C@@H1](CC2CC2)C1)N3CCC(C4=CN(CC5CC5)N=N4)CC3 C=CC[C@]1(C(=O)NCC2(C(C)(F)F)CC2)CCN(C(=O)CCN(C)CCC)C1 COC1=CC=C(C(=O)N2CC(F)(F)C[C@H1]2CNC(=O)C3=CN=C(C4CC4)O3)C=N1 C[C@H1](NC(=O)CCN1CCCCC1)C2CN(C=3C=CN4N=CC=C4N=3)C2 CC[C@H1](C(=O)NC[C@H1]1CCC[C@@H1]1NC(=O)C2=CSC(Cl)=N2)N(CC)CC C[C@H1](C(=O)N[C@H1]1CC[C@H1]1CNC(=O)C=2C=NC3=NC=CN3C=2)C4=CC=CS4 CCN1N=NC=C1C(=O)N2CC3(CCC3)C[C@@H1]2C(=O)N(CCC4CC4)CC5CC5 C[C@@H1](C(=O)N1CCN(C(=O)[C@H1]2CCC2(C)C)C[C@@H1]1CC(F)(F)F)N3C=CN=C3 COCC=1C=C[NH1]C=1C(=O)N2C[C@@H1](O)[C@@H1](CNC(=O)[C@](C)(NC(C)=O)C3CC3)C2 N#CC1(CNC(=O)C[C@@H1](NC(=O)[C@@H1]2CC(=O)C23CCC3)C(F)(F)CO)CCC1 CC1(C)C(CC(=O)NCC=C(C(C)(C)C(=O)N2CC=C[C@H1](O)C2)C)C1(C)C CN(C(=O)C1(NC(=O)CC2=CC=CC(F)=C2)CC(F)(F)C1)[C@H1]3COCC3(C)C CN(C[C@@H1]1CN(C(=O)[C@@H1](F)CC2CCCC2)CCO1)C(=O)C3=CC([N+1](=O)[O-1])=C[NH1]3 COC1=CN=CC=C1C(=O)NCCCOCCC(=O)N2CCO[C@@H1](CCF)C2 CC[C@H1](CCCC(=O)N[C@H1](C)C1=NC=C(C)O1)NC(=O)C2=COC(N(C)C)=N2 COC1=CC=CC(N2N=C(C3=CC=CC(C)=C3)N=C2C=4C=NSC=4C)=C1 CC1(C)OC[C@@H1]2C[C@@]21NC(=O)CC3=CCN(C(=O)[C@@]4(C)CC4(C)C)CC3 CC[C@H1](CNC(=O)C1(CC(C)C)CC1)NC(=O)CCN(C)CCC(C)(C)C CC1=CC=C(CNC(=O)N=C2C=C(C3=CC=CC(C)=C3)[NH1][NH1]2)C=C1F CN1C=CC(CCC(=O)NCC(C)(C)CNC(=O)C[C@H1]2CNC(=O)O2)=N1 COCC=CC(=O)N[C@H1]1C[C@@H1](NC(=O)COCCC2=CC=C([N+1](=O)[O-1])C=C2)C1 C/C=C/C[C@@H1](C)C(=O)N[C@@](C)(CO)CNC(=O)C=CC1=CC=CC2=CC=CN=C12 CC(C)[C@@H1](O)C(F)(F)C(=O)N1CCCO[C@@H1](CNC(=O)C[C@@H1]2COC3CC2C3)C1 CC1=CC(F)=C(C(=O)NCC#CCNC(=O)C2C[C@@H1](C)C[C@H1](C)C2)C=C1F CC(=O)NC1(CC(=O)N2CCC[C@](F)(CNC(=O)CC(C)(C)C3CC3)CC2)CC1 O=C(N[C@@H1]1CCC[C@@]12CCN(C(=O)C=CC3=CN=C(O)N=C3O)C2)C4=CSN=N4 O=C(C[C@@H1]1CCCOC1)NC[C@@H1](O)C2CCN(C(=O)C(F)(F)C(F)(F)F)CC2 COC1(CNC(=NCC(=O)NC(C)C)N2CC[C@H1](O)[C@@H1]2C)CCCC1 CSC1=CC(F)=CC=C1C(=O)N[C@H1]2CC(F)(F)C[C@H1]2NC(=O)C3=CSC=C3F CN(CCCNC(=O)C1=C[NH1]C(C2=CC=CC=C2)=C1)C(=O)C3=CC=NC=N3 C[C@H1](O)[C@H1](NC(N)=O)C(=O)NCCC1=CCN(C(=O)CC2=NN=C(S)N2C)CC1 CC=CC=CC(=O)N[C@H1]1CN(C(=O)C2=CC3=C(S2)CCC3)C[C@@H1]1C CCNC1=NC=C(C(=O)NC[C@@H1](NC(=O)C=CC2CC2)C3=CC=CC=C3)C=C1Cl CC1=CC=C([C@H1](C)C(=O)N2CCN(C(=O)C3=C[NH1]C=CC3=O)CC4(CC4)C2)S1 CCOP(C)(=O)CCNC(=O)[C@]1(C(F)(F)F)CCN(C(=O)OC(C)(C)C)C1 CCCCCC1=NC(C(=O)N[C@@H1]2CN(C(=O)C=3SC=C(C)C=3Cl)CC24CC4)=CS1 C[C@H1]1CC[C@@H1](NC(=O)CN(C)CCC2=CC=CC=C2)CN1C(=O)CCC(C)(C)O CCOC1(C(=O)NCC(CNC(=O)CC2=CC=C(Br)C=C2C#N)CCC)CC1 CC(C)(CNC(=O)[C@H1]1CC=CCO1)CC2CN(C(=O)[C@H1](O)C3=CC=CC=C3Cl)C2 C[C@@H1](CC1CCCC1)C(=O)N2C[C@@H1](C(=O)N[C@H1](CO)CCCO)CC23CCC3 CCN1CC[C@H1](C(=O)N2C[C@@H1]3C[C@H1]2[C@@H1]3NC(=O)CN(C)C(C)C)C1 O=C(NCCN1CCCC1)[C@H1]2C[C@@H1]2C(=O)NC3=CC=CC4=NC=C(Br)C=C34 CC(F)(F)C(=O)NC1CC(CCNC(=O)[C@]2(C3=CC=CC=C3)CCC(=O)NC2)C1 CC[C@H1](C)NC(=O)[C@@H1](C1=CC(Br)=CO1)N(C)C[C@]2(O)CCOC2 C=C[C@H1](O)C(=O)NC1[C@H1]2COC[C@H1]1CN(C(=O)C3=CC=CC=4C(C)=COC3=4)C2 CC(=O)OCCCC(=O)N1CCN(C(=O)C2=CC=CC=3OC=CC2=3)C[C@H1]1C(F)F CCCC1=NC(C)=C(C(=O)N2CCC(C3(NC(=O)C4=COCCC4)CC3)CC2)O1 CCC1=CC(C(=O)NC2(CCCC(=O)N3CCC[C@@H1](C)C3)CCC2)=C(C)O1 COC(C(=O)N1CC2(CCN2C(=O)CN3C=NC(Br)=C3)C1)CCC4=CC=CC=C4 CC1=CC=NC=C1C(=O)N(C2=CC(O)=NC=N2)C3CC4(CCNCC4)C3 CCO[C@@H1]1C[C@@H1]1C(=O)N2[C@H1]3CC[C@@H1]2C[C@@H1](CNC(=O)C4CCN(C5CC5)CC4)C3 CCCCC[C@H1](O)CC(=O)NC[C@@H1]1COC(C)(C)CN1C(=O)C2=CSC(C)=C2C CCCN(CCNC(=O)C[C@H1]1COCCN1C)C(=O)C2=CC(C3CC3)=CC=N2 CC[C@H1](CN(C)C(=O)C1=CCCC[C@@H1]1C)NC(=O)C2=C(F)C=C(OC)C=C2F CC1=NC(C(=O)NC[C@@H1](C)NC(=O)C2=CN3C=CC(C)=CC3=N2)=C(C)O1 CN1C=NC=C1[C@@H1](O)C(=O)N2[C@H1]3CC[C@H1]2CN(C(=O)C[C@@]4(C)CCS(=O)(=O)N4)C3 C#CC1=CC=CC([C@H1](C(=O)NCC(F)F)N2CCC(C)(C)[C@@H1](CO)C2)=C1F O=C(CC1=CN=NS1)NC[C@@H1]2CCN(C(=O)[C@@H1]3CCS(=O)(=O)C3)C24CC4 O=C(NC1=CC=C2C(=C1)OCCO2)[C@H1](C3=CCCCC3)N4CCC[C@@H1]4CC5CC5 CNC(=O)C1=CC(Br)=CC=C1N[C@@H1](C2=CC=CC(C)=C2C)C3=NN=NN3C4CC4 CCCN(C)CC(=O)N1CC[C@@H1](N(C)C(=O)C2=CSC(Br)=N2)C3(CC3)C1 C=CCN(C)CCN(CC)C(=O)[C@@H1](NC(=O)C1=CC=CN=C1CC)[C@@H1](C)O CC1=CSC=C1C(=O)NC[C@H1]2CCCCCN2C(=O)C3=CC(O)=CS3 CC[C@@](C)(Cl)CNC(=O)C[C@H1]1CCC[C@@H1](NC(=O)C2=CC=C(F)C(C)=C2)C1 O=C(N[C@@H1]1[C@@H1]2CCCCN(C(=O)C3CC(F)(F)C3)[C@H1]2C1)C4CC(N5C=CC=N5)C4 CC(C)N1C=C(C(=O)NC[C@H1]2CC3(CO2)CN(C(=O)CCNC(=O)CO)C3)N=N1 CCCN(CCNC(=O)C1=COC(Cl)=C1)C2=CC=C([N+1](=O)[O-1])C3=CC=CN=C23 CC[C@@](C)(CNC(=O)C1=CC=CC=C1CN(C)C)NC(=O)C2=NC(Cl)=CS2 CC1=C(C(=O)NC[C@H1]2CN(C(=O)C(C)(C)C(F)F)CC(C)(C)O2)C(C)(C)CCC1 CO[C@H1](C)CCC(=O)N1CCN(C(=O)CC2=C[NH1]N=C2O)[C@@H1](C(F)F)C1 C[C@@H1](F)CC(=O)NCC1(O)CCN(C(=O)[C@H1]2C[C@H1]2C)CC1 CCN1C=C(CC(=O)N2C[C@H1]3C[C@H1](NC(=O)C4=CC(C)=CN=C4N)C[C@H1]2C3)N=N1 CO[C@H1](CSC)C(=O)N[C@H1](C(=O)N(CC(N)=O)CC(N)=O)C1=CN(C)N=N1 CC(=O)OCCC(=O)N1CC[C@@H1](N(C)C(=O)[C@H1](C)CC=2C=NN(C)C=2)C3(CC3)C1 CCN(C)CC(=O)NC[C@@H1]1C2=CC=CC=C2CCN1C(=O)C[C@@H1]3CC3(Cl)Cl NC(=O)CC[C@@H1](N)C(=O)N1CC[C@H1]2CN(C(=O)C3C[C@H1](N)C3=O)CC[C@H1]21 O=C(NC[C@H1]1CC2=CC=CC=C21)[C@@H1](O)[C@H1]3CCC4=CC=CC=C4O3 COC1=CC(O)=CC=C1CN2CCCC[C@@H1]2C(=O)N[C@@H1](CO)C3=CC=C(C)C=C3 NC1=NC=CC=C1C(=O)N[C@H1]2CCC[C@@H1]2NC(=O)[C@H1]3CCN(C4=CC=CC=C4)C3 CC=1C=C(C)N(C2=CC=C(C(=O)N[C@H1]3CC[C@@H1]3N(C)C)C=C2F)N=1 O=C1C=NC=C(Br)N1CC2=NC(CCCO)=NN2CC3=CC=CC=N3 CC=1OC=CC=1C(=O)N[C@@H1](C)[C@@]2(O)CCN(C(=O)C3=CC=C(CC(C)C)C=C3)C2 N#CC1(C(=O)N2CC[C@@H1]([C@@H1]3CCN(C(=O)CC4=CC=NO4)C3)C2)CCC1 CC[C@H1](CNC(=O)[C@H1]1COC2(C1)CN(C(=O)[C@]3(CC)CCNC3=O)C2C)C(C)C CC[C@H1](NC(N)=O)C(=O)N(CC)CCCNC(=O)[C@H1](O)C1CCOCC1 C[C@H1](CC1=CN=C[NH1]1)C(=O)NC(C)(C)CN(C)C(=O)C2(C3CC3)CC=CC2 CC1=C(C(=O)N2CCC=C[C@@H1]2C(=O)N3CCC(F)(CF)CC3)CCO1 CCC=1[NH1]N=C(C(=O)N[C@@H1](CNC(=O)C2=CC(O)=NC(Cl)=C2)C(C)C)C=1Cl CC(C)(C(N)=O)C(=O)N[C@@H1]1C[C@@H1](O)[C@@H1](CNC(=O)CC=2C=NOC=2)C1 C=CC[C@H1](OC)C(=O)N1CC2(C[C@H1](C(=O)N(C)CCC(F)(F)F)CO2)C1 CC(C)N1N=CC(Cl)=C1C(=O)N[C@H1]2CC[C@@H1](C)N(C(=O)C(F)=CC3CC3)C2 CC1=CC(CNC(=O)[C@H1](CNC(=O)[C@@H1]2CC3=NC=CN3C2)C(C)C)=NO1 CC1(NC(=O)C2=CC(C(C)(F)F)=CC=N2)CC(NC(=O)[C@@H1]3CCCOC3)C1 CCN(C[C@H1]1CCCCN1C(=O)COC(C)=O)C(=O)C#CC2(C)CC2 CCN(C(=O)CC=1C=CSC=1Cl)C2CCN(C(=O)CC3=CC(C)=CC(C)=C3)CC2 C[C@@H1](CCN(C)C(=O)[C@]12CCC[C@@H1]1C2(F)F)NC(=O)C3C=CC=CC=C3 CCC[C@H1](NC(=O)CN(CCNC(=O)COCCOC)C1CC1)C(=O)OC CC(C)=CCN=C(NC[C@@H1]1CC1(C)C)NCC(C)(C)C2=CC=CS2 C[C@H1](C(=O)NC1CCC(CNC(=O)C=2C=NN(CCO)C=2)CC1)S(N)(=O)=O C#CC1=CC=C(CC(=O)N[C@H1]2COC[C@H1]2C(=O)N[C@H1]3CCOCC34CCC4)C=C1 CC1=CN2C=CN=C(C(=O)N3CCC[C@H1](NC(=O)[C@H1](C)CN(C)C)C3)C2=N1 COCCCNC(=O)[C@H1](CC[C@@H1]1CCCO1)N2CC[C@@H1]3CCCCC[C@@H1]3C2 CCS[C@@H1](C)C(=O)N1CC[C@](CCOC)(NC(=O)C2=NC=C(Cl)C=C2Cl)C1 C#C[C@@H1](CC(C)C)NC(=O)C1(CNC(=O)CS(=O)(=O)NC)CCC1 COCCC(=O)NC[C@H1]1CCCN1C(=O)C=2SC(N(C)C)=NC=2Cl CC=1[NH1]C(=N)SC=1C(=O)N[C@@H1](CNC(=O)CNC(=O)C2=CC(Cl)=CC=N2)C3CC3 C=CCOCC(=O)N[C@H1](CNC(=O)C1(N2C=CC=N2)CC1)[C@H1](C)C(C)C CC[C@H1](C)CCC(=O)N(C)CCN(C)C(=O)C[C@@H1]CN1C=NC(C2CC2)=N1 CC[C@H1](C)C(=O)NC1=CC=CC(NC(=O)C2=CC=CN=N2)=C1 CCCCC[C@@H1](O)CNC(=O)[C@@H1](CCC)NC(=O)C1=CSC=C1OC CCS(=O)(=O)NCC(=O)NC[C@@H1](NC(=O)C1COCCOC1)C2=CC=CC=C2 C[C@H1](CC(=O)N[C@@](C)(CNC(=O)[C@@H1]1[C@H1](C#N)C1(C)C)C2CC2)C3=CC=CO3 O=C(N[C@H1]1CCC12CCN(C(=O)[C@@H1]3C[C@H1]3C(F)F)CC2)C4=CN=CN=C4C5CC5 C#C[C@H1]1CCN1C(=O)[C@@]2(N=[N+1]=[N-1])CCN(C(=O)C3=CC=C(C)C(O)=N3)C2 CC=C(F)C(=O)NC[C@H1]1CN(C(=O)C2=NC(C)=C(C)[NH1]C2=O)CC1(C)C CC1=CON=C1C(=O)N2CC[C@H1](N(C)C(=O)CCC3=NC=CC=C3C)C4(CC4)C2 CC1=CN=C(NCC=2C=NN(CCO)C=2)C(S(=O)(=O)NCC=3C=CSC=3)=C1 CC(C)(O)CCC(=O)N1CCN(C(=O)C=2C=C(C3CCC3)ON=2)C[C@@H1]1C(C)(C)C CC1=C(Br)C=CC=C1C(=O)N2CCN(C(=O)CC[C@H1](C)C#N)CC[C@H1]2C C#CCOC(=O)CNC(=O)[C@@]1(F)CCCN(C(=O)[C@@H1]2CCCN2C(N)=O)C1 CC1=C(C(=O)N[C@]2(C(=O)N(C)C[C@@H1](O)CN(C)C)CCN(C)C2)COCC1 C#CC[C@H1](C)C(=O)N[C@@H1](C)CCCNC(=O)C=1C=NN(C(C)C)C=1Cl C[C@@H1]1C[C@@H1](NC(=O)CSCC2=CC=CC=N2)CCN1C(=O)CN3CCCCC3 CCOC(=O)C1(S(C)(=O)=O)CCN([C@@H1](CC[C@@H1]2CCCO2)C(=O)NCC3CC3)CC1 CCN(CCNC(=O)C(C(F)(F)F)C(F)(F)F)C(=O)C1=CON=C1COC CNC(=O)CCC(=O)N1CC[C@H1](NC(=O)C2=CC=CC3=NC(C)=NN23)[C@H1](CO)C1 CC(C)CC(=O)N[C@H1]1CN(C(=O)C2=CC=C3C(=C2O)CCC3)CC[C@@H1]1CO CC(C)C1=CC=CC=C1C(=O)N[C@@H1]2CCCCN(C(=O)C3=C[NH1]C(=N)N=C3O)C2 CO[C@H1]1CCN(C(=O)C[C@H1]2CCCN(C(=O)[C@@H1](OC)C3CC3)C2)[C@H1]1C CC=1N=CSC=1CCC(=O)N2CCCC[C@H1]2CCN(C)C(=O)C=CC=3C=N[NH1]C=3 CNC=1SC=NC=1C(=O)N2CCC(/C=C/C(=O)N3C[C@@H1](C)CC[C@H1]3C)CC2 CC[C@H1](CNC(=O)CC1=NN=C(C)O1)NC(=O)[C@H1]2C[C@H1]3C[C@@H1](O)C[C@H1](C3)C2 CC1=CC(CC(=O)N[C@]2(CNC(=O)CC3=CC=C(Cl)S3)CCOC2)=C(C)S1 CC1=NC(C)=C(C(=O)N2CC[C@H1]3C[C@]32C(=O)NCC4=CN=CN4C5CC5)S1 CN(CCC1(C)N=N1)CC2=CC=C3C(=C2)OCC3 CSC1CN(C(=O)C(=CC2=CC=CC(N3CCCC3)=C2)C4CC4)C1 COC12CCC(C(=O)N3CCCC[C@@H1]3C4=NC=CC(Cl)=C4F)(CC1)CC2 CCC(CC)[C@@H1](F)C(=O)N1[C@H1](C(=O)NC[C@H1]2OCC[C@H1]2C)C[C@@H1]3CCC[C@@H1]31 C=CCSCC(=O)N1CC[C@H1](CNC(=O)C2=CC(Cl)=CC=3N=C(C)[NH1]C2=3)C[C@H1]1C CC[C@H1](C(=O)NC[C@@H1]1CCN(CCN=[N+1]=[N-1])C1)C2=CC=C3C(=C2)OCO3 CC(C)C1=CC(C(=O)N[C@@H1](C)C(C)(C)C2=CC=C(N)C=C2)=NC3=NC=NN13 CC=CCC(=O)N1CC[C@H1]2CCN(C(=O)C3=C[NH1]C(=N)C=C3C)[C@H1]2C1 CCC1=CN=CC(C(=O)N[C@H1](CC=2C=N[NH1]C=2)C(=O)N(C)OCC(F)(F)F)=C1 CCCCC(=O)N[C@H1]1C[C@H1]1CNC(=O)C2=CSC3=CN=CC=C23 CCOC1=CC=C(CNC(=O)C2(F)CN(C(=O)C3=CN(C)N=C3C)C2)C=C1OC CC(C)CC[C@@H1](C)NC(=O)C[C@@H1](NC(=O)[C@H1](C)CC(F)F)C(F)(F)F C=CCCCCCCC(=O)N1CC([C@H1]2CCCCN2C(=O)[C@@H1](CO)N(C)C)C1 CC[C@H1]1OCC[C@H1]1C(=O)NNC(=O)CN2CC=CC2 CCCN1C=CC(C(=O)N(C)CCOCCCN(C)C(=O)C=2[NH1]C(C)=CC=2C)=N1 CC(=O)C1=CC=C(C2=N[NH1]C(=NCC3=CC=CC=C3O)S2)C=C1 COC[C@@H1](ON)C(=O)N[C@H1](C)C=1C(C)=N[NH1]C=1C C[C@H1](CN(C)C(=O)C1=CC=C(O)C=C1)NC(=O)[C@@H1](O)CCN(C)C CCC[C@H1](O)CCNC(=O)[C@@H1](NC(=O)C1=CN=NN1CC)C2CCCC2 COC1=NC=C(Cl)C=C1C2=CN(CCCCCC(=O)NC[C@H1]3CC3(F)F)N=N2 COC[C@H1](C(=O)N[C@H1]1CN(C(=O)CSC2=NC3=CC=CC=C3O2)C[C@H1]1C)N(C)C CCOC(=O)C1=CSC(CN[C@@H1](C2=NC=CC=C2Cl)C3=NN=NN3C4(C)CC4)=N1 CN=C1[NH1]C(=NCCCCCC2CC2)[NH1]C(=NCCCC3=CC=C(Br)C=C3)[NH1]1 CN(C)C1CC(CC(=O)NC[C@@H1](CNC(=O)C2=CC=CC(N)=C2)C(F)(F)F)C1 O=C(NC[C@H1]1CC12CC2)C3=N[NH1]C4=C3CN(C(=O)CC(C5CC5)C6CC6)C4 O=C(NC1CCN(C(=O)C2=CC=3C=CSC=3S2)CC1)C4=CC=C5C(=C4)COCC5 O=C(CNC(=O)[C@H1]1CCCN(CC2=NC=CC=C2Cl)C1)NC3=CC=CC=N3 CC1=CC2=NC=CN=C2C=C1C(=O)NCC3(CNC(=O)C(C)(C)CO)CCCC3 CC(C)(C)CCCCC(=O)NC[C@H1]1CCCN(CC2=NC(C(F)F)=NO2)C1 C[C@@]1(S(=O)(=O)N[C@@H1](C2=CC=NC(Cl)=C2)C3CC3)COCCO1 CCOC[C@H1](O)CN(C)C(=O)C=1C=C(CNC(=O)CN2C(C)=CC=C2C)[NH1]N=1 CON=CC(=O)N[C@@H1]1CN(C(=O)CCCCCN(C)C)CC(C)(C)C1 CN1C[C@H1](C(=O)N(C)[C@@H1]2CCCC[C@@H1]2NC(=O)CCOC3CCCC3)NC1=O COCCN1C=C(C(=O)N2C[C@@H1](O)[C@H1](N(C)C(=O)C=C(C)Cl)C2)C=N1 CC[C@H1](CN(C)C(=O)C1=CC(C2=CC=CO2)=C[NH1]1)NC(=O)C3=C(C)N=CN3C CSCCNC(=O)C1=NC(C=2C=C3N(C=2)CCCC3)=C4C=CC=CN14 CC1=N[NH1]C(C)=C1[C@H1](C)C(=O)NCCC[C@@H1]2CCCN2CCO COC1=CC=CC(C=CC(=O)NC[C@@H1]2C[C@H1]2NC(=O)C3(C(N)=O)CCC3)=C1 CN(CCNC(=O)[C@@H1]1C[C@]1(C)C(F)F)C(=O)CSC2=CC=CC(Cl)=C2 C[C@@H1]1CN(C)CCN(C(=O)[C@@]23CO[C@@H1](CNC2=O)C3)C1 CC1=CC(Cl)=C(C(=O)N2CCC[C@H1]2[C@H1](C)NC(=O)C3=CC=C4C(=C3)[C@H1](C)CO4)S1 COC(=O)C1(NC(=O)[C@@]23CC[C@@H1](CN(C(=O)C4(F)CCCC4)C2)C3)CCC1 CCCOCCC(=O)N1CCCC[C@H1]1[C@@H1](C)NC(=O)CC COCC[C@H1](CNC(=O)C1=CN=CC=C1N(C)C)NC(=O)[C@@H1](C)C2=CN=CS2 COCO[C@@H1](C)C(=O)N(C)C[C@H1](C)CNC(=O)CC1(CO)CCOCC1 CCOC(=O)C1=NC(C(=O)NC[C@@H1](C)CNC(=O)C2=CN=C([C@@H1](C)OC)S2)=CS1 CN(C(=O)C1=CC=NC2=C1OCO2)[C@@H1]3CCN(CC4=CC=CC(O)=C4O)C3 CCCC[C@@H1](CNC(=O)[C@@H1]1CCC2=CC=CC=C2O1)NC(=O)C3=CN=NS3 O=C(NCCC1(NC2=NC3=CC=CN=C3S2)CCC1)C4=N[NH1]C5=C4CCSC5 CC1=CC=C(CC(=O)N2CC(CCO)(NC(=O)C3CC(F)(F)C3)C2)C(F)=C1F C[C@@H1]1CCN(C(=O)C=2C=C3N(N=2)CCC3)[C@@H1]1CNC(=O)CS(=O)(=O)C4CC4 C#CCCC(=O)N1CCN(C(=O)[C@@H1]2C[C@H1]2C3=CC=NN3CC(C)C)C[C@H1]1CF CC=1C=NC2=C(C(=O)NC[C@@H1](C)N(C)C(=O)C3=CN=C(Cl)S3)C=NN2C=1 C[C@H1]1CSCN1S(=O)(=O)C2=CC=CC(=NC[C@@H1]3CCC4=CC=CC=C4O3)[NH1]2 C[C@@H1](C[C@@H1](C)NC(=O)[C@]1(O)CCOC1)N=C2[NH1]C3=CC=CC(Br)=C3O2 COC(=O)C1=C(Br)C=CC=C1COC(=O)C2=CC(Br)=CN2C CO[C@@H1]1CN(C)[C@@](C)(C(=O)N(C)C[C@@H1](O)CN(C)C(=O)C(C)(C)CO)C1 CN1N=CN=C1CCCNC(=O)C2=CC[C@@H1](NC(=O)CO[C@@H1]3CCOC3)C2 CC1=NO[C@](C)(CNC(=O)CNC(=O)CNC(=O)[C@@H1]2C[C@H1](F)CN2C)C1 CCCCN1N=CC(C(=O)N2CC[C@](C)(CNC(=O)C(C)(C)C(C)(C)O)C2)=C1C CC1=CC(NC(=O)C[C@@H1]2CCC[C@H1](O)C2)=CC=C1NC(=O)C=3C=CC(=O)N(C)N=3 C=CC[C@@]1(NC(=O)C[C@@H1]2C[C@H1]3C[C@H1]3C2)CCCN(C(=O)C4=CC=C(N)C=C4Cl)C1 CC[C@H1](C(=O)N1CC(O)(CNC(=O)[C@H1](C)C2=CN=CC=N2)C1)C3(O)CCCCC3 COC(=O)[C@H1](NC(=O)C[S@](=O)C1=CC=C([N+1](=O)[O-1])C=C1)C2=CC=CC(I)=C2 CCC[C@H1](NC(=O)C1=CC[C@H1]2CC[C@H1]1N2C(=O)C3=CN=C(C)[NH1]C3=N)C(=O)OC COC(=O)C1=NC(C(=O)NC[C@@H1]2CCC3(CO2)CC(NC(=O)C4=CC=C[NH1]4)C3)=CS1 C=C[C@](C)(CC)C(=O)N1CC[C@H1]1CNC(=O)[C@@H1]2[C@H1]3[C@H1]4C[C@@H1]5[C@@H1]6[C@H1]4[C@H1]2[C@@H1]6C[C@H1]53 CC1=CN=C2N1CCC[C@H1]2CNC(=O)C(=O)N3[C@H1]4CCC[C@H1]3CC4 CS(=O)(=O)CC(=O)N[C@@H1]1CCN(C(=O)C2=CC(C(F)(F)F)=NC=C2Cl)C[C@H1]1F CN(CC(=O)NCCOCCN(C)C(=O)[C@H1](O)CC(N)=O)C(N)=O COCC1=CC(C(=O)N2CCC[C@@H1]2C(C)(C)CNC(=O)C3=CC(C)=C[NH1]3)=C(C)O1 C[C@@H1]1CN(C(=O)C[C@@H1]2CC=CCC2)C[C@H1]1N=C3C(Cl)=C[NH1]C=C3[N+1](=O)[O-1] CCCC(=CC(=O)N[C@@H1](C)C1=NOC=C1C(=O)NC[C@@H1](O)C2CC2)CCC CN(CCC(C)(C)NC(=O)C1=CCCCO1)C(=O)C2=CC=CN3C=NC=C23 C=C1CC[C@@H1]1C(=O)N[C@@H1](CCOC)CNC(=O)CS(=O)(=O)CCCCC CC=1SC2=NC=C(C(=O)N(CC3=CC=C(C)O3)C4CCC4)N2C=1C CC1=CC(C)=C(C(=O)N(C)CCNC(=O)CCNC(=O)C=CCl)C(C)=N1 COC1=CC=C(Cl)C(C(=O)N2CC[C@H1](NC(=O)C3=CC=CC(F)=C3)[C@H1]2C)=C1N CC1=CC=CC(OCCCC(=O)N[C@H1]2C[C@@H1]2NC(=O)[C@H1](C)C#N)=C1C C[C@@H1]1CN(C(=O)CN2C=C(N)C=N2)CCN1C(=O)C3=CC=C(Br)C(O)=N3 C=CCC1(C(=O)N2CCCC[C@H1](CNC(=O)[C@@H1](C)OCCN(C)C)CC2)CCC1 C[C@H1]1C[C@H1]2CN(C(=O)CNC3=CC=C(S(N)(=O)=O)C=C3[N+1](=O)[O-1])C[C@@H1]21 CC(C)C[C@H1](O)CC(=O)NCC[C@H1]1CN(C(=O)C(C)(C)CC(F)F)CCO1 NC1=CC=C2[NH1]C(C(=O)N3CC[C@@]4(CO[C@H1](CCOC=O)C4)C3)=CC2=C1 CC[C@@H1](NC(N)=O)C(=O)N[C@@H1]1CC12CCN(C(=O)C3=CC(Cl)=C(Cl)[NH1]3)CC2 CCNC(=O)CN1C=C([C@@H1]2[C@H1](C)CCN2C(=O)[C@@H1](C)N3C=CC(C4CC4)=N3)N=N1 C=C[C@@H1]1COC[C@H1]1NC(=O)C=2N=C(CNC(=O)C(C)(C)COC(C)C)OC=2C C[C@@H1](O)CCCCCC(=O)N[C@H1]1C=CCN(C(=O)C2=CC=C(C3=CC=CO3)O2)C1 O=C(C=1N=C2SC=CN2C=1Cl)N3[C@H1]4CC[C@H1]3CC(N5CC6=CN=CN=C6C5)C4 CC1=CC(C(=O)N[C@H1]2CCC[C@@H1]2CNC(=O)C=CCF)=CC=C1C(F)F O=C(C1=CC=C(CO)C(F)=C1)N2CCN(C(=O)[C@@]34C=C[C@@H1](CC3)C4)CC25CCC5 CO[C@H1](CNC(=O)C1=CC(CNC(=O)C2=CCCCCC2)=NO1)CSC N#CC1=CC=C(F)C(CNC2=CC=C([C@@H1]3CNC(=O)C3)C=C2)=C1F O=C(CC1=CC=C2N=CC=CC2=C1)NC3=CC=C(C4=CC=CN=C4)C=C3 CCC1=NOC=C1C(=O)N2CC[C@]2(C)CC(=O)NC(C)(C)C3=CC=CS3 CC1=CC=C(C=CC(=O)N2C[C@H1](C)[C@@H1](NC(=O)CCC(C)(C)O)C2)S1 CCN1N=C(C(C)C)C=C1C(=O)NCC2(CN(C)C(=O)[C@H1]3CC[C@H1]4C[C@H1]43)CC2 CCN1CCC[C@@H1]1CN(C)C(=O)CCCCCN(C)C(=O)C2(C(C)=O)CC2 COC1=NC(Cl)=C(C(=O)N2CCC[C@@]3(C2)CN(C(=O)C45CC(CO4)C5)CCO3)S1 C[C@@H1](CN(C)C(=O)CN1C=C(C(F)(F)F)C=N1)NC(=O)C[C@@]2(C)CCCO2 CC1=CC=C(COC(=O)[C@@H1](C)SC2=CC=C(F)C(F)=C2)C=C1O COC(=O)[C@H1]1C[C@@H1](C(=O)N[C@@H1]2CC[C@@H1](C)N(C(=O)C3C(C)(C)C3(C)C)C2)C1 CC[C@H1](CC(=O)NC1(C(F)F)CC(NC(=O)[C@H1]2CCCN2C=O)C1)C(C)C CC(C)[C@@H1](O)C(C)(C)C(=O)N(C)CCOCCNC(=O)COCC=1N=C[NH1]N=1 O=C(N[C@@H1]1CCN(CC2=CC=C(Br)C=C2)C1)N3CC(C4=NN=CS4)C3 NC1=CC=C(F)C(C(=O)N2C[C@H1]3CCN(C(=O)C4=CC=C(Cl)C=C4Cl)[C@H1]3C2)=C1F CC=1[NH1]N=C2C=C(C(=O)NC[C@H1](O)CN(C)C(=O)[C@H1]3CC(C(C)C)=NO3)C=CC=12 CN(C)CCN1C=CC(C(=O)N[C@H1]2C[C@@](C)(NC(=O)[C@@H1]3CCC(F)(F)C3)C2)=N1 CN(CC(=O)N[C@]1(CNC(=O)C2CC(C)(O)C2)CCOC1)C(=O)C3=CC=CC=C3 C=CCCC1(C(=O)N[C@H1]2CCCCN(C(=O)CO[C@H1]3CCC[C@@H1](C)C3)C2)CC1 COC1=CC=CC=C1C2=CC=NC(C(=O)NC3=CC=C(Cl)C4=CC=NC=C34)=C2 COC1=CC=C(C(=O)NC(C)(C)CCN(C)C(=O)C=2OC=CC=2C)C=3SC=CC1=3 CCCN1N=CC(C(=O)N2CCCC(NC(=O)[C@H1](C)C(F)F)CCC2)=C1C3CC3 CC(C)[C@@](C)(CNC(=O)C[C@H1]1CCOC1=O)NC(=O)CN2CCN(C)CC2 CC1=CC(C=CC(=O)N2CC[C@H1](C)[C@@H1](CNC(=O)C3=CCC3)C2)=CC=C1F C#CC[C@](C)(NC(=O)C1CC1)C(=O)N(C)C[C@H1](C)C(=O)OC C=C1CC2(C1)CC(C(=O)N3C[C@@]4(NC(=O)[C@@H1]5C(Cl)(Cl)C56CC6)CC[C@H1]3C4=O)C2 COC1=CC=C(CC(=O)O)C=C1NC(=O)CCNC(=O)[C@@H1](C)N2CCCCCC2 O=C(NCC1=CN(C2=CC(Cl)=C(Cl)C=C2Cl)N=N1)C3=CC=C4C=CC=CC4=C3O CC1=CON=C1CC(=O)N[C@@](C)(CO)CNC(=O)[C@@H1]2CS(=O)(=O)CC(=O)N2 CC(C)OCC(=O)NC[C@@H1](CC1=CC=CC=C1)N(C)C(=O)[C@H1]2C[C@](C)(F)C2 CCOC(CN1C=C(C(=O)N[C@H1]2C[C@H1](CNC(=O)C[C@H1](C)CF)C2)N=N1)OCC CCO[C@@H1](C(=O)OCC1=C(F)C=NC=C1Cl)C2CC(F)(F)C2 CN(CC(C)(C)NC(=O)[C@@H1]1C[C@H1]1C2=CC=C(Br)O2)C(=O)[C@H1](CO)NC(N)=O COC1=CC=C(C(=O)NC(C)(C)CCCNC(=O)[C@H1]2CN3CC[C@H1]2C3)C(C)=C1 CN(C(=O)C1=C(Cl)CCCC1)[C@H1]2CN(C(=O)[C@H1]3CC[C@@]4(CC3)CC4(F)F)C[C@H1]2F C#CCNC(=O)CNC(=O)[C@H1](OC)C1CN(C(=O)C2=CN=C(C)C(C#N)=C2)C1 O=C(N[C@@H1]1CCCCCN(C(=O)C2CC3(CCC3)C2)C1)C4=CC=NC=5[NH1]C=NC4=5 C[C@@H1](C(=O)NC[C@@H1]1COCCN1C(=O)C#CC2=CC=CC=C2)N3C=NN=N3 C#CCN(CCC(=O)N(C)C[C@H1]1COCCO1)C(=O)[C@@H1](CC#C)C2CC2 C[C@]1(C(=O)NCC2(O)CC(C(=O)N3CC[C@H1](CO)[C@H1](O)C3)C2)C[C@H1]4C=C[C@H1]1C4 CCOC(C)(C)C(=O)NCC1(C)CCN(C(=O)[C@H1](OC)[C@@H1](C)CC)CC1 CC1=CC2=C(C=C1C)O[C@H1](C(=O)N3C[C@@H1](O)[C@H1](NC(=O)CC/C=C/C(C)C)C3)C2 CCOC(=O)C=1N=C(NC(=O)[C@H1]2CC[C@@H1](NC(=O)C3=CC=CN=C3Cl)CC2)SC=1Cl CC[C@@H1](C(=O)N[C@H1]1CC[C@H1]2CCN(C(=O)C=3C=NN(C)C=3N)[C@H1]1C2)N(C)C CC/C=C/C[C@H1](C)C(=O)N1CCN(C(=O)CCC=2C=CSC=2)C[C@@H1]1CC3CC3 O=[N+1]([O-1])C1=CC=C(OC(=O)C2=COC(Cl)=N2)C(Cl)=C1 C[C@@H1]1OC(C)(C)N(C(=O)OC(C)(C)C)[C@@H1]1CNC2=NC=C3C(=N2)CCC3 C/C=C/C[C@@H1](CC)C(=O)N1CC(SC)(C(=O)N2CCC[C@@H1]2CN(C)C)C1 CC[C@@H1](CC(=O)NC1(CC)CCN(C(=O)[C@]2(Cl)CC2(F)F)CC1)CN(C)C CC#CCCC(=O)N1CC[C@]2(NC(=O)C3=CC=C4N=CSC4=C3)CCCCC[C@H1]12 CC#CCCC(=O)N1C[C@H1](CO)C2(C1)CN(C(=O)CN3C=NC(C#N)=N3)C2 CCN(C(=O)C1=CN2C(C)=CC=CC2=N1)[C@@H1]3CCCN(C(=O)CC4=CC=CO4)C3 C#CC(C)(C)CNC(=O)C=1OC(CNC(=O)CCC2=CN=CN=C2)=CC=1C CC(C)[C@H1](NC(=O)[C@@]12CC[C@@H1](CN(C(=O)[C@@H1]3CC=C[C@H1](O)C3)C1)C2)C(=O)N(C)C CC(C)(C)OC(=O)N1C[C@@]2(C)C[C@@]2(C(=O)N3CC(CCC(F)(F)F)C3)C1 CC=1OC=NC=1CCNC(=O)C(=O)N2CCC[C@@]2(C)CC3=CC=C(F)C=C3F O=C(N[C@H1]1CCCCN(C(=O)[C@H1](O)C2=CC=CC(F)=C2)C1)[C@H1](O)C(F)(F)F CCC1=CN=CC(C(=O)NC[C@H1]2CCN(C(=O)CCCC3=NN=C(C)N3C)C2)=C1 CC(C)C[C@@H1](C(=O)O)C(=O)N1C[C@H1](C)O[C@H1](C(=O)NC[C@@H1](C)CC(F)(F)F)C1 C=C[C@H1]1CN(C(=O)CCOC2=CC=CC=C2F)C[C@H1]1NC(=O)C=C(C)C CN1N=NC=C1CC(=O)NC[C@@H1]2C[C@H1](C(C)(C)C)CCN2C(=O)C#CC3CC3 FC1=CC=C(N2CCN(CC3=CC(Br)=CC=C3I)CC2)C=C1 COC(=O)C1=NSC=C1NC(=O)[C@]23C[C@@H1]2CN(C(=O)C4=CC=NC(Cl)=C4Cl)C3 CCS(=O)(=O)CC(=O)N[C@H1](C)CNC(=O)COCC=CC1=CC=CC=C1 CCCC(C)(C)CC(=O)N1CC[C@H1]2CC[C@@H1](C1)N2C(=O)C3(F)CCCC3 NS(=O)(=O)CC(=O)N1CCOC2(CCN(C(=O)CC3=CC=CC(F)=C3Cl)CC2)C1 CN1N=CC=C1C2(C(=O)N3C[C@@H1]4CN(C(=O)CC5=CC=C(F)C=C5)C[C@H1]4O3)CC2 CC(C)C1=CC=CC(NC(=O)C2(F)CCN(CC3=CSC(Br)=N3)CC2)=C1 CN(CC(=O)NC[C@H1]1C[C@@H1]1NC(=O)CCCN2C=CC=N2)C3CCCC3 CCCCCCN1C=C(CO[C@@H1]2CCCN(C(=O)[C@@]3(C)CC=C(C)CC3)C2)N=N1 CCN(CC)C[C@@H1](F)C(=O)NC[C@]1(CNC(=O)[C@@H1]2C(C)(C)C2(F)F)CC13CCC3 CCCN1CCCC[C@@H1]1C(=O)N2CCN(C(=O)C3=COC=C3C)[C@H1](C(C)(C)C)C2 CC[C@H1](C)[C@@H1](O)C(=O)NCCCN=C1[NH1]C=NC2N=CN(C)C12 CC[C@H1](COC)C(=O)N[C@H1](C)C1CCN(C(=O)[C@@H1](C)SC)CC1 C[C@@H1](C(=O)NC[C@H1]1COC[C@H1]1NC(=O)CCOC2COC2)C3=CC=CO3 C=C1COCCN(C2=NC(N3CCO[C@H1](CC(N)=O)C3)=NC4=CC=CN=C24)C1 CCOC1=CC=CN=C1NC(=O)[C@@H1]2C[C@H1]3CC[C@H1]2N3C(=O)[C@H1]4C[C@@H1]5CC[C@H1](C4)O5 C[C@@H1]1C[C@@H1](CNC(=O)C2CCS(=O)CC2)CN1C(=O)C3=CC=CC=CC=NN3 C=CCN(CCC(=O)NC1CCN(C)CC1)C(=O)C=2OC=CC=2C CC(C)CC[C@H1](NC(=O)[C@H1]1CC=CCC1)C(=O)N[C@@H1]2COCC[C@H1]2O C#CCCCCCCC(=O)N1CCN(C(=O)CCC2=CC=CC=C2F)[C@H1](CC)C1 CCC[C@H1]1CN(C(=O)C=2C=C[NH1]N=2)CCN1C(=O)C3=CC=CC(Cl)=C3F CCCC1(C(=O)N2CC=C[C@H1](NC(=O)C=3C=NN(C4CC4)C=3C)C2)CC1 N[C@@H1](CC1=CC=C(Cl)C(Cl)=C1)C(=O)N2CCSC[C@@H1]2C3=NC=CS3 CCN1C=NN=C1C(=O)N(C)C[C@@H1]2CN(C(=O)C=3C=C(C)N(C)C(=O)C=3)CCO2 CC1=NN(C(F)F)C(C)=C1CC(=O)NC[C@H1](CO)CNC(=O)CCC2=NC=CS2 O=C(N[C@@H1]1CN(C(=O)C2=CC3=CC=C(F)C=C3O2)[C@]4(CCOC4)C1)C5=CSC=N5 O=C(NCCCN1CCOC1=O)C2=C[C@]3(CCN(C(=O)C4=CN=CN=C4)C3)C2 CC(=O)OCCCC(=O)N(C)C[C@H1](C)C(=O)N[C@H1]1CC[C@H1](O)C1 CN(C(=O)C#C[C@@H1]1CCOC1)C2CN(C(=O)C3=CC=C(C4=CC=CO4)O3)C2 C[C@@H1]1CCN(C(=O)C[C@H1]2CC(=O)NC2=O)C[C@@H1]1CNC(=O)CSS(C)(=O)=O CO[C@H1]1C[C@H1](C(=O)OC)N([C@@H1](CCC2=CC=CC=C2)C(=O)NC)C1 CC1=CC(C(=O)N2C[C@H1]3CCC[C@@H1](C2)C3C(=O)N[C@@H1](C)[C@H1]4CCOC4)=C(C)C=N1 CCC(C)=C(C)C(=O)N1[C@H1]2CC[C@@H1](C(=O)N[C@@H1](C)C=3C=C(C)ON=3)[C@H1]1CC2 CCC(=O)NCC(=O)N[C@H1]1C[C@H1](OC)CN(C(=O)[C@H1](OC)C2CCCCCC2)C1 CC1=CC=C(C(=O)N2CC[C@@]3(CCN(C4=CC=NC(CO)=N4)C3)C2)C(O)=N1 CCC1(CO)CN(C(=O)[C@@H1]2C[C@H1](C)CN(C(=O)CCCC(C)=O)C2)C1 CN1CC[C@@](NC(=O)C2CCC=CCC2)(C(=O)N[C@H1]3CCCN(O)C3=O)C1 CC(C)(C)C#CC(=O)N1C[C@H1](C(=O)N2CCC(O)(C(N)=O)CC2)CC1(C)C C=C[C@@](C)(O)C(=O)N[C@H1](CO)CNC(=O)C=1SN=NC=1C2CC2 C#C[C@H1]1CCC[C@H1]1NC(=O)[C@H1](C)N(CCC)C(=O)C[C@@H1]2CC[C@H1](O)C2 C=CCCOCC(=O)N1CCN(C(=O)C2=CN=C(O)N=C2O)C[C@@H1](O)C1 C=C[C@@](O)(C(=O)N1CCC(C)(NC(=O)CCC(C)(C)C)CC1)C(F)(F)F C[C@@H1]1C[C@H1](NC(=O)CN2C(=O)CC(C)(C)C2=O)CN1C(=O)C3(C4CCC4)CC3 CC(C)[C@@H1](CNC(=O)C=CC1CCCC1)NC(=O)[C@@H1]2CCOC(C)(C)C2 COC=1C=C(C(=O)N2CC3(C2)CN(C(=O)[C@H1]4CC[C@H1]5C[C@H1]5CC4)C3)SC=1Cl C#CCNC(=O)CC(=O)N1CCC2(CC1)CC(NC(=O)[C@@H1](C)OC)C2 CC1=NC(CC(=O)NCC23CCC(NC(=O)C=CBr)(CC2)CO3)=CS1 C[C@H1](C(=O)[C@H1](C#N)C1=NC=C(CC2=CC=NC(C)=C2C)S1)N3CCN(C)CC3 CC(C)[C@@H1](C(=O)NC/C=C/CNC(=O)C[C@@H1](C)C1=CC=CO1)N(C)C O=C(CCC1=CC=NC=N1)N[C@H1]2CCC[C@@H1]2NC(=O)C3=CC=4SC=CC=4C=N3 CO[C@@H1]1CN(C(=O)[C@@H1](O)CC(F)F)C[C@H1]1NC(=O)C2=CC(Br)=CC=C2F CN(C[C@H1](O)CF)C(=O)C=1C=C(C2=CC=C([N+1](=O)[O-1])C=C2)[NH1]N=1 CC1=CC=C(O)C(C(=O)NCC[C@H1]2[C@@H1](C)CCCN2C(=O)C=3N=CN(C)N=3)=C1 CC1=CC=C(C(=O)N(C2CC2)[C@@H1](C)C(=O)N3CCOC[C@](C)(O)C3)S1 C[C@]1(C(=O)N2CCC(NC(=O)C3=C[NH1]C4=CC=CC(Cl)=C34)CC2)CCC[C@@H1]1O O=C(NCC1=NC=CC2=C1CCCC2)C3CCC4(CCNC4)CC3 C[C@H1](C(=O)N[C@H1](C)[C@@H1](CO)NC(=O)COC(C)(C)C)C1=CC=CC2=CC=CC=C12 COC1=CC=C2C=C(C(=O)N[C@@H1]3CC[C@H1]3CNC(=O)CSC)SC2=C1 C#CCC[C@H1]1CCCN(C(=O)[C@@H1](N)CC2=CC=NN=C2)C1 CCOCC[C@H1](NC(=O)C1=CC(O)=CC(=O)O1)C(=O)N(C)CCC(=O)OC O=C(CC1=CSC=N1)N[C@H1]2CC[C@@H1](CCNC(=O)C3=CC=NC=4C=C[NH1]C3=4)C2 C#CCC(CC#C)C(=O)N1CCN(C(=O)C=2N=CSC=2C)CC[C@H1]1C CC1=NOC(C)=C1/C=C/C(=O)NCCC[C@@H1](C)NC(=O)[C@@H1]2C[C@H1]2[N+1](=O)[O-1] CN1CCC[C@@H1]1[C@H1]2COCCN2C(=O)C3=CC4=CC(C#N)=NC=C4[NH1]3 CCS[C@H1](C)C(=O)NC[C@H1](CC(C)C)NC(=O)C=1C=C(C2CC2)OC=1C3CC3 FC1=CC=C(N[C@@H1](CCC[C@@H1]2CCCO2)C3=CC=CC=C3F)C=C1OC(F)F C[C@@H1]1C[C@H1](CNC(=O)C2=CN(CCO)N=N2)CN1C(=O)C3=CN=C(S)N3C4CC4 COC(=O)CC[C@@H1]1CCCCN(S(=O)(=O)CCN=[N+1]=[N-1])C1 CCC1(C(=O)N2CC=C[C@@H1]2CNC(=O)C3=CC=C4SN=NC4=C3)CCCCC1 C[C@@]1(C(=O)NCC2(NC(=O)CCS(N)(=O)=O)CCOCC2)CCC3=CC=CC=C31 C=C[C@@H1](C)C(=O)N1CCC[C@@H1](C(=O)N2CC(=O)N(C)[C@H1](C)CC2)C1 CCC(CC)CC(=O)N[C@H1](CO)CCCCNC(=O)CCC1=CN=C(C)N=C1O CC1=NOC(C)=C1CCC(=O)NCC2(C)CCN(C(=O)CC3=NC=CN3C)CC2 CCNC(=O)CCC(=O)N[C@]12CC[C@H1]1CN(C(=O)C3=CC=C(C(F)(F)F)[NH1]3)C2 CC1=CC=C(NC(=O)[C@@H1]2C[C@@H1]3CC[C@@H1]3C2)C=C1S(=O)(=O)N4CCCC4 CCC[C@@H1](CC)CCC(=O)NCC1(OC)CN(C(=O)[C@@]2(O)CCOC2)C1 O=C(/C=C/C(F)(F)F)NNC(=O)NC1=CC=CC(CN2CC[C@@H1](O)C2)=C1 CC1=NN=CC=C1C(=O)NC[C@@H1](N2CCN(C(=O)CCC[C@H1](C)O)CC2)C(F)F CCOCC1=NC(C2=CC=CN3C=CN=C23)=NN1[C@@H1]4C[C@H1]5CC[C@H1]4C5 COC(=O)CC1CN(C(=O)C2(NC(=O)C[C@H1]3CCSC3)CC2)C1 CCN1CC[C@@H1]1C(=O)N(C)CCN2CCN(C(=O)C3=CC=CC=C3C(C)C)CC2 CC(C)(C)OC(=O)N[C@H1](C(=O)NC[C@H1](CO)CNC(=O)CS(N)(=O)=O)C(C)(C)O CC(CN(C)C(=O)C1=C(N)C(F)=CC=C1F)NC(=O)C(C)NC(=O)C2CCCC2 C=CCCO[C@@H1](C)C(=O)N(C)C1CN(C(=O)[C@H1]2CCC3=NC=NC(C)=C3C2)C1 C[C@@H1]1CN(C(=O)CCCN(C)C)CC[C@H1]1CNC(=O)C(F)=C2CCCC2 CCC1=CC(C(=O)N2CC[C@@](O)(CCNC(=O)[C@@H1]3CCC4=NC=CN43)C2)=NC=N1 CC(C)N(C)CC(=O)NC[C@]1(C)CN(C(=O)[C@H1]2CC[C@@H1](C(C)(C)C)O2)C(C)(C)C1 C=C=CCCC(=O)N[C@](C)(CC=C)C(=O)NC[C@](C)(O)[C@@H1](C)CC C[C@H1](C(=O)NCCN(C(=O)[C@@H1]1CNC(=O)C[C@@H1]1C)C2CCCC2)N3CCOCC3 CCC1=NC=CN=C1C(=O)N2C[C@@H1](CNC(=O)CCC3=CN=C(C)O3)CC[C@@H1]2C CCC1=C(C(=O)N[C@H1]2C[C@H1]3CC[C@H1]2N(C(=O)C4(F)CC5(CCC5)C4)C3)N=NN1C C#CC[C@@H1](C(=O)NCCCCCNC(=O)C=1C=C(C(C)C)N(C)C=1C)C2CC2 CCOCCS(=O)(=O)NCC(=O)N[C@H1]1CCN(C(=O)[C@H1](C)S(C)(=O)=O)C12CC2 O=S(=O)(NC[C@H1](F)CO)C1=CC=C2[NH1]C(=NCC=3C=CC4=NON=C4C=3)SC2=C1 CN(C(=O)COC1=CC=C(Cl)C(F)=C1)[C@@H1](CNC(=O)COC2CC=CC2)C3CC3 CC1=CC=C(C(=O)N[C@@H1]2COCC[C@@H1]2NC(=O)[C@]3(C)CCCN3C)O1 C[S@](=O)CCC(=O)N1CCC(F)(CNC(=O)C[C@H1]2CCCC3(CC3)C2)CC1 CC1(C)COCC[C@@H1]1C(=O)NCC2=CN(C3=CC=CC=C3)C=N2 C=CC[C@@H1](CNC(=O)[C@]1(C)CCN(C)C1=O)NC(=O)C2=CSC(S)=N2 CC1(C)CC(CCN2CC[C@H1]3CCC[C@@H1](C2)N3)(NC(=O)OC(C)(C)C)C1 CCC1=CC=C(C(=O)N[C@@H1]2C[C@@H1]3C[C@H1]2N(C(=O)CCS(=O)(=O)N(C)C)C3)N=C1 C[C@@H1]1C[C@@H1]1CC(=O)NC[C@H1]2CN(C)CCN2C(=O)C3=CC(=O)N(C)C=N3 C1=NC(NCCO[C@@H1]2CC2(F)F)=CC(N3CC[C@H1]4OCC[C@H1]4C3)=N1 CC1=NC=CC(C(=O)NC[C@H1](C)NC(=O)[C@@H1]2CCOC3(CCCC3)C2)=N1 CCCC[C@H1](CC)CCCN(C)C(=O)[C@@H1]1CCCN1C2=CC(O)=NC(C)=N2 CC=1C=C(C(=O)N2CCC([C@@H1](CO)NC(=O)[C@@H1]3CC(=O)N(OC)C3)CC2)N(C)N=1 CC(C)N(C)C(=O)CCC(=O)NC[C@H1]1CN(C(=O)CNC=O)CC[C@]12CCOC2 CCC[C@@H1](C)CC(=O)N1CC[C@@](F)(C(=O)N[C@H1]2[C@H1]3CC[C@H1]4[C@@H1](C3)C[C@H1]42)C1 CCN(C(=O)CCCN1C=C([C@@H1]2CCOC2)N=N1)[C@@H1]3CCN(C)C3 N#CC1=CC(N[C@H1](C2=CC=CC(F)=C2)C3=CC=CC=N3)=C([N+1](=O)[O-1])S1 CCCC1=CC=C(C(=O)N2CCC[C@](CO)(NC(=O)CCNC(N)=O)C2)S1 C=CCCCCCCC(=O)N1CCN(C)[C@@H1](C(=O)N2C[C@@H1](N(C)C)C3(CC3)C2)C1 CC1=C(C)C[C@@H1](C(=O)NCCOCCN(C)C(=O)[C@H1]2CCCNS2(=O)=O)CC1 CC1=NOC(C(=O)NC[C@H1]2CN(C(=O)C3=CC(C)=C4[NH1]C=NC4=C3)C[C@@H1]2C)=N1 CCOC1(C)CN(C(=O)[C@@H1]2C[C@H1](O)CCN2C(=O)[C@@H1]3CCCC(C)(C)C3)C1 C#CC1(C(=O)NC[C@H1](O)CNC(=O)CC2=NOC=C2C(C)C)CCCC1 CCN=C1C=C(C(=O)N2CC3(C[C@H1](NC(=O)CCC(F)F)CO3)C2)C=C[NH1]1 C[C@H1](CO)C(=O)N[C@]1(CNC(=O)C2(N(C)C)CCC2)CCCC[C@H1]1C CN(C[C@@H1](O)CNC(=O)[C@H1]1CC2=C[NH1]C=C2S1(=O)=O)C(=O)COC=3C=NN(C)C=3 CCOCC(=O)NC12CC(CNC(=O)CCNC(=O)C3=CC=CC(Cl)=C3)(C1)C2 CC1=NC(C(=O)N[C@@]2(C#N)CCN(CC3=CN=C(Br)C(F)=C3)C2)=CC=C1F CC=1[NH1]N=C(C(=O)N2CCC3(CC2)OCCC[C@H1]3NC(=O)CC(C)(C)C)C=1C CC1=NC=C([N+1](=O)[O-1])C=C1C(=O)NCC(C)(C)CNC(=O)CCSC2CCCC2 CC(C)(C)[C@@H1](C#N)C(=O)N1CCC(C(=O)NC[C@@H1](F)C(C)(C)O)CC1 CCN(C[C@@H1]1CCCN1C(=O)C2=CC=C3C(=C2O)CCC3)C(=O)CC(C)(F)F CC=1SC(C(=O)N[C@@H1]2CCC[C@@H1](NC(=O)C3=CC=NC=C3)CC2)=CC=1S(N)(=O)=O CC1=CSC(C(=O)N2CCC[C@@](CO)(CNC(=O)[C@H1](O)CN(C)C)C2)=C1Cl C[C@@H1]1CN(C(=O)C(=O)NCC(F)(F)F)CC[C@H1]1CNC(=O)C=2N=CN(C)N=2 CC1=CC(O)=C(C(C)C)C=C1C(=O)N2C[C@H1](NC(=O)C=C3CCSCC3)[C@H1]4C[C@H1]42 COC1=CC=CC=C1C(=O)NNC(=S)NC2=CC=C(C#N)C(Cl)=C2 C#CCC1(NC(=O)[C@H1](CNC(=O)[C@@H1]2CCC[C@H1]2CC)CC3CC3)CCCCC1 CC(C)[C@H1](C#N)C(=O)N1CCC[C@H1]([C@@H1]2CCCCN2C(=O)CCNC(N)=O)C1 CCN1C=C(NC(=O)N2CCC[C@@H1](CN3C=CN=C3)C2)C(C)=N1 CC(C)C1=NC(=NCC[C@@H1]2CCCCN2C(=O)C3=NC(C4CC4)=NC=C3Cl)S[NH1]1 CNC1[C@@H1](O)[C@H1](CC(=O)NCCC2CCN(C(=O)[C@@H1](O)CC=3C=NN(C)C=3)CC2)C1 O=C([C@@H1](O)C1=CC=CC2=C1OCC2)N3CCN(C(=O)[C@@H1]4CC45CC5)CC3 CC[C@@H1](C)C=CC(=O)N1CCC=C[C@@H1]1C(=O)NCC2=N[NH1]C(C)=C2C CCC=1OC=NC=1C(=O)N[C@H1]2CCCO[C@H1]2C3CCN(C(=O)[C@@H1](C)SC)CC3 CN(CC=1C=COC=1)C(=O)[C@H1](CC2=CN=C[NH1]2)NC(=O)C3=CN=C(Cl)N3C C=C(CCNC(=O)[C@]1(C#N)CC1(C)C)CNC(=O)C=2SC3=CC(F)=CC=C3C=2Cl CCN(CCCNC(=O)[C@H1]1CCN(CC2=CC=CC=C2)C1)C(=O)[C@@H1](O)CC(C)C C[C@]1(CNC(=O)C2=CC=C(CN3C=CC=N3)C=C2)CCN(C(=O)[C@H1]4C[C@H1](O)C4)C1 CC#CCCC(=O)N[C@H1]1CCN(C(=O)CC2(O)CCCCC2)C[C@H1]1OC COC(=O)CC[C@@H1]1CN(C(=O)N2CC[C@H1](NC3=NC=CC=N3)[C@@H1](C)C2)CCO1 C[C@]1(C(=O)N2CCO[C@@H1](C(=O)N3CCC(CF)CC3)C2)CCC(=O)NC1 CN1CC[C@@](C)(C(=O)N2C[C@H1](NC(=O)C3=NOCC3)[C@@H1]4CCCC[C@@H1]42)C1 CC[C@@H1]CC(=O)N1CCN(C2=NC=C(Cl)C=C2[N+1](=O)[O-1])C[C@@](C)(F)C1 C[C@@H1]1[C@@H1](NC(=O)C2=CC=C(C3=CC=NC=C3)C(F)=C2)CCN1C(=O)CNC=O CCN(OC)C(=O)C[C@H1]1CCCN(C(=O)C2[C@H1](C)[C@H1]2C)C1 O=C(CC1=CC=C(F)C=C1)NC[C@]2(F)CCCN(CC3=CC=C(I)O3)C2 CC(C)(CNC(=O)CC1=CC=CN=C1Cl)[C@H1]2CCCN2C(=O)[C@@H1]3CCS3(=O)=O C[C@H1](C(=O)N1CC(OCCC(=O)NC2(C)CC(O)C2)C1)C=3C=CN(C)C=3 O=C1N[C@@H1](C(=O)N2C[C@@H1](NC(=O)[C@H1]3C[C@H1]4C=CC[C@H1](C4)C3)[C@H1](C(F)F)C2)CO1 CN1N=CN=C1C(=O)N[C@@H1](CCC2=CC=C(F)C=C2)C(C)(C)C CC1=CSC(C(=O)N2CCC(NC(=O)CCNC(N)=O)CC2)=C1Br CSCCC(C)(C)C(=O)NC[C@H1]1C[C@@H1](NC(=O)[C@H1](C)C2=CC=C(F)C=C2)C1 COC1=CC=C(C2C=CN(C[C@@H1]3CCN(C(=O)C=C(C)Cl)C3)N=N2)C(Cl)=C1 C[C@@]1(C(=O)N[C@H1]2C[C@H1]3CC[C@H1]2N(C(=O)CCCCC4=CN=C[NH1]4)C3)CC1(F)F COC1=CC=C2C(C(=O)N[C@@H1](CO)CNC(=O)C(F)=C(C)C3CC3)=N[NH1]C2=C1 COC(=O)C1=CC(C(=O)N2CC(NC(=O)C(C)(C)C3=CC=NS3)C2)=CC=C1C CC[C@H1](CCOC)C(=O)N[C@H1](CCF)C(=O)NCCC=1C=C(C)N(C)N=1 CCCCC(CCCC)C(=O)NCC12CC(NC(=O)CCN(C)C(C)=O)(C1)C2 CC1=CC=C(NC(=O)C23CC(NC(=O)[C@H1](C)C[C@H1](C)C(C)=O)(C2)[C@@H1]3COC)C=N1 C=C(C)CCC(=O)N[C@H1](CC)CCC(=O)N[C@@H1](CC(C)C)C(N)=O CC(=O)N[C@@H1](C)C(=O)N[C@@H1]1C[C@H1]1C(=O)NC2=CC=C3C(=C2)C(=O)N(C)C3=O CN(CCNC(=O)C1=CC(Cl)=CC(Cl)=C1N)C(=O)CCCC(N)=O CON=CC(=O)NC[C@@H1]1CCN(C(=O)[C@@H1]2CCCC=3N=N[NH1]C=32)C14CCC4 CSC1=CC=C(C)C(C(=O)N2CCN(C(=O)C[C@@H1](C)N3C=CN=C3)CC24CC4)=C1 CC1=C(F)C=CC(C(=O)NC[C@H1](CO)NC(=O)C2=CC(F)=CC(Cl)=C2O)=C1Cl CN1C=C(N2C[C@@H1](NC(=O)NC[C@H1]3CCC(=O)N3)CC2=O)C=N1 CC1=NN=C(O)C(NC(=O)C2=CC3=C(S2)CCN(C(=O)[C@@H1](C)S)C3)=C1C C=CC[C@]1(NC(=O)C2=CSC=C2C(F)(F)F)CCCN(C(=O)[C@@H1]3[C@@H1](C)[C@H1]3C)C1 CCC(=O)NC1=CN=CC(C(=O)NC[C@](C)(O)CNC(=O)CCOCC2CC2)=C1 O=C(CSCC1=CC=C(Cl)S1)NC[C@@H1]2C[C@H1]3CC[C@@H1]2N3C(=O)[C@@]45C[C@@H1](F)[C@@H1]4C5 CCC(C)(C)OCC(=O)N(C)CCCNC(=O)C=1C=NN(C(F)F)C=1 CC[C@H1](COC)C(=O)N(C)CCN(C)C(=O)C=1N=COC=1C2CCOCC2 C=CCO[C@@H1](C)C(=O)N[C@@H1]1[C@H1]2C[C@@H1]3[C@H1]1[C@@H1]3[C@@H1]2C(=O)N4CCC[C@H1](C#N)C4 CC[C@@H1](CNC(=O)CC1=CSC(C=2C=CSC=2)=N1)NC(=O)[C@@H1]3[C@@H1](C4CC4)C3(F)F CCN(C(=O)C1=CN(C)C=C1C)C2CCN(C(=O)C3=NN=C(C)C=C3O)CC2 C[C@H1]1C[C@@H1](C(=O)NCC2(C3CC3)CC2)N1C(=O)C4=CSN=C4Cl O=C(NC[C@H1](O)C(=O)N1CCC2=C[NH1]N=C2C1)C3=CSC(O)=N3 C#CC1(C(=O)N2CC(CNC(=O)C=3OC=CC=3C(C)C)(C(N)=O)C2)CCCC1 CC[C@@H1]1OCC[C@H1]1C(=O)NCC[C@@H1](C)CCNC(=O)C2=CC=NC(Cl)=C2N C[C@]1(C(F)(F)F)CCCN(C(=O)[C@@H1]2C[C@H1]2[C@H1]3CCCN(C(=O)CCCN)C3)C1 CCCSCC(=O)N1CCN(C(=O)C=2N=CSC=2C(C)C)C[C@H1]=CCCC[C@@H1]1 CN1CCN(C(=O)[C@H1]2CC23CCN(S(=O)(=O)C4=CN=CC(Br)=C4)CC3)CC1(C)C C[C@@H1]1O[C@H1](C)C[C@@H1]1CC(=O)NC[C@]2(C)CCCN2C(=O)[C@H1](C)C3CCC3 CC=1C=NSC=1C(=O)NCCCCCN(C)C(=O)[C@@H1]2[C@H1]3CCCC[C@H1]32 O=C(C[C@@]1(O)CCCOC1)NCC2(NC(=O)C=3C=CC4=NN=C(S)N4C=3)CCC2 C[C@@H1]1C[C@H1](C(=O)N[C@H1]2C[C@H1](F)CN(C(=O)C=CC3=CC=CC=C3C#N)C2)CCO1 C[C@@H1]1C[C@@H1]1C(=O)N[C@H1]2COC3(C2)CN(C(=O)CC4=CC=CC5=NON=C45)C3 CCC(C)(C)C(=O)N[C@H1]1CCN(C(=O)C=CC(=O)N(C)C)[C@H1]1C2=CC=CC=C2 CC[C@H1](CNC(=O)C1=CC=C2C(=C1)CCOC2)NC(=O)[C@@H1]3OCCN(C)C3=O CCCCN1C=C(C(=O)NC[C@](C)(F)CNC(=O)[C@@H1](O)C2CC2)C(C)=N1 C[C@H1]1CN(C(=O)C2=CC=C(CNS(C)(=O)=O)O2)CC[C@@H1]1NCC=3C=CN(C)N=3 CC1=NN(C)C=C1C(=O)N2CCC(/C=C/C(=O)N[C@H1]3CS[C@H1](C)C3)CC2 CCN(CCN1CC=CC1)C(=O)[C@H1]2CC=C[C@H1](NC(=O)C[C@@H1](C)OC)C2 NC1=CN=CC=C1C(=O)NC2=CC=C(NC(=O)[C@@H1]3C[C@@H1]4C[C@@H1]4C3)C=C2 CCN1C=NN=C1C(=O)NC[C@H1]2CN(C(=O)[C@]3(C#N)CC4CCC3CC4)CCO2 C[C@@H1]1C[C@@H1]1C(=O)N[C@H1]2C=CCN(C(=O)C3=CC=NC=C3Br)C2 CC[C@H1](O)CC(=O)N1CC2(CC[C@H1](C(=O)NC3=NC(C#N)=CS3)O2)C1 [N-1]=[N+1]=NCC1=CC=C(C(=O)N2CC(NC(=O)[C@@H1]3C[C@@H1]4CCC[C@@H1]43)C2)C=C1 CC1=C(N)C=CC(C(=O)N[C@H1]2C[C@](F)(CNC(=O)C3=CCC(C)(C)CC3)C2)=C1C O=C(NC12CCN(CC1)CC2)C3(CNCC4=C(F)C=C(Br)C=C4F)CC3 C[C@H1](O)C(F)(F)C(=O)N1CC[C@H1](C(F)(F)F)[C@H1](NC(=O)C2=CC=CN(O)C2=O)C1 CCCC(=O)NCC(=O)N[C@@H1](C)[C@H1]1CCCN(C(=O)CN2C(=O)CCC2=O)C1 CC(C)C[C@H1]1C[C@@H1]1C(=O)N[C@@H1](C(=O)N2C[C@H1](O)[C@H1](O)C2)C3=CC=CO3 COCC[C@H1](C)C(=O)NCC1(O)CC(NC(=O)CN(C)CC2=CC=C(C)C=C2)C1 CC(C)(O)CC(=O)NCC1(CNC(=O)C2=CC=CC3=C2CCC3=O)CC1 CCC=1ON=CC=1C(=O)N2C[C@@H1](C)C[C@H1](NC(=O)C3=C(C)C=NN3C)C2 CCC(=O)N1CC[C@@H1]2CC[C@@H1](NC(=O)C[C@H1]3CN4C=CN=C4NC3=O)[C@@H1]21 CCC[C@H1](O)CC(=O)N(C)CCCNC(=O)C1=CC=C2N=C(S)OC2=C1 CCC(CC)N(C)CCC(=O)N[C@@H1](C)CNC(=O)C=1C=NN(C(F)(F)F)C=1 CC1=NOC(C)=C1SCCNC(=O)CCCCCN CNS(=O)(=O)NCC(=O)NCCCCNC(=O)C[C@@H1]1CCC1(C)C COC1=CC(C(=O)N(C)[C@@H1]2CN(C(=O)C3=CC=C(C)C=C3F)CC2(C)C)=NN1C CC(=O)C1=CC=CC(OCC(=O)N[C@@]2(CO)CCCN(C(=O)[C@H1](C)C3CC3)C2)=C1 CC[S@](=O)CC(=O)NCC[C@@H1](C)N(C)C(=O)[C@H1](C)C1=CC=C(F)C=C1 CC1=CC(CN2CCNC[C@@H1]2C(=O)NC3=CC=CC(N4C=NN=C4)=C3)=NN1C C#CC[C@](C)(NC(=O)CCCN(C)C)C(=O)N[C@@H1]1CCC[C@@H1](C)C1 CC[C@H1](CC(C)C)C(=O)NC1([C@@H1]2CCCN2C(=O)[C@H1]3C[C@H1](F)C3)CC1 CCO[C@H1](C)C(=O)N1CCC[C@@H1]1[C@@H1]2CCN(C(=O)CN3N=CC4=CC=CN=C43)C2 CO[C@H1]1C[C@@H1](C(=O)NCCN(C)C(=O)C2=CC=CC3=C[NH1]N=C23)C1 CC1(C)CN(CC(=O)N2CC(N3C=C([C@@H1]4CCCO4)N=N3)C2)C(=O)O1 CC[C@@H1](C1=CC=CC2=C13)C=NN=C(C=CC=C3N=S(C)C=C)O2 C#CCCO[C@@H1](C)C(=O)N[C@@]1(CO)CCCN(C(=O)CN2C=C(Cl)C=N2)C1 O=C(NC[C@H1]1[C@@H1](C2CC2)CCN1C3=CC=C4C(=N3)CCC4=O)[C@@H1](O)C5=CC=CO5 CC(C)(C#N)C(=O)NC1CC(CNC(=O)C2=CC=3SC4=CC=CC=C4C=3S2)C1 CCN1C=CC(C(=O)N(C)[C@H1]2CC[C@H1](CNC(=O)C(C)(C)SC)CC2)=N1 CN(C)C[C@H1]1C[C@@H1]1NC(=O)C[C@@H1](NC(=O)CC2=CC=C[NH1]2)C(C)(C)C CC1=NOC=C1CC(=O)NC[C@H1]2C[C@@H1](O)CN2C(=O)[C@H1]3CCC4=NC=NC=C4C3 COC1=CN=CN=C1C(=O)NC23CC(C(=O)NC[C@@H1]4CCC(F)(F)C4)(C2)C3 CC(C)(C)OC(=O)N1C[C@H1](NC(=O)N[C@H1]2C[C@H1]2C3=CC=C(C#N)C=C3)C(=O)O1 CC1=CC=CC(C[C@@H1](CO)NC(=O)N(C)CC2=CN=NN2C)=N1 C#CC1(C(=O)NC2CCC([C@@H1](C)O)CC2)CN(C(=O)C=3C=C[NH1]C(=N)N=3)C1 CSC1(CNC(=O)[C@H1]2C[C@@H1](NC(=O)CC=3C=COC=3)CCO2)CCC1 COC1=NSC=C1C(=O)N2CCC3(CCC[C@H1]3NC(=O)C[C@H1](O)CC4CC4)CC2 CC[C@](C)(CNC(=O)C(F)(F)C(F)(F)F)NC(=O)[C@@H1](C)OC1=CC=C(C#N)C=C1 CCOC(=O)CCNC(=O)[C@H1](C1=CC[C@@H1](C(C)C)NC1=O)N2CCC[C@H1](OC)C2 CO[C@@H1]1CC[C@]2(C(=O)N[C@@H1]3[C@H1]4CCN(C(=O)CCC5=CC=CC(F)=C5)C[C@H1]43)C[C@@H1]12 CC=1OC=NC=1C(=O)N[C@H1]2CCC[C@H1](NC(=O)C3=CN=CN=C3C4CC4)CC2 CC=C[C@H1](O)C(=O)N(CCNC(=O)C1CCC1)C[C@H1](C)O CC1(C)CC(CC(=O)NC[C@@H1]2CN(C(=O)C[C@@H1]3CCCC(=O)N3)CCO2)C1 CCOC1=NC(N2C[C@@H1]3CC[C@@H1](NC(=O)[C@@H1]4CCC[C@H1](C)C4)C[C@H1]3C2)=NC=C1Cl O=C(N[C@@H1]1CN(C(=O)C2=CC=C(Cl)[NH1]2)C[C@@H1]3CCC[C@H1]13)C4CS(=O)(=O)C4 C[C@@H1]1CC[C@@H1]1C(=O)NCC2=CC=C(C(=O)NC[C@@H1](O)CN3C=CC=N3)O2 COC1=CC=C(CN2C[C@@H1](F)[C@H1](NS(=O)(=O)CC3=CC=C(Cl)C=C3Cl)C2)C(C)=C1 CCC1CC(S(=O)(=O)NOC[C@H1](O)C2=CC=CC=C2)C1 CO[C@@H1]1CC[C@]2(C(=O)N3C[C@H1](C)[C@@H1](C(=O)NC4=C[NH1]C=CC4=O)C3)C[C@H1]12 C=C=CCC(=O)NCC(C)(C)CNC(=O)[C@@]12CC[C@@](C(F)F)(CO1)C2 C[C@@H1](CCNC(=O)[C@@]12CC[C@@H1](C[C@@H1]1F)C2)NC(=O)COCC3CCCC3 CCOC[C@@H1](C)C(=O)N[C@H1](C)CCCNC(=O)C1=CC=C(CS(C)(=O)=O)O1 CO[C@H1]1COCC[C@H1]1CC(=O)NC2CN(C(=O)C3=CC=[N+1]([O-1])C=C3)C2 O=C(COCCF)NCCC1(O)CCN(C(=O)CCC2CC2)CC1 COCCCNC(=O)[C@H1]1CCCN(C(=O)C2=CC=C(Br)C(Cl)=N2)C1 O=C(COCC1=CC=CC=C1Cl)NC[C@@H1]2CN(C(=O)C#CC3CC3)[C@H1]4C[C@@H1]42 C#CC1=CC=C(C(=O)NC[C@H1]2[C@H1](C)CCN2C(=O)C#CC3CC3)C(OC)=C1 CC=CC1=CN(C[C@H1](C)NC(=O)C=2C=C(S(C)(=O)=O)OC=2C)N=N1 CCOC1=CC(Cl)=CC=C1CN=C(NCC(F)F)N2CC[C@@H1](NS(C)(=O)=O)C2 CSCC[C@H1](NC(=O)C1=CC=C(OC(C)C)N=N1)C(=O)NC[C@H1]2CN(C)CCO2 CC(C)[C@@H1](CCNC(=O)[C@H1]1CC(=O)N(CC(F)(F)F)C1)NC(=O)C2(CCO)CC2 CCOCCN1N=NN=C1[C@@]2(NC3=CC=C(Br)C(CO)=C3)CCCC[C@@H1]2C CC[C@@H1](C)CCC(=O)N(CC)[C@H1]1CCCN(C(=O)CCN2N=C(C)C(C)=C2C)C1 CCCCCCC(=O)N1CCC(CCNC(=O)[C@H1]2CC=CC3=CC=CC=C32)CC1 CSC1=NC(C)=CC(N2CC3(CCN(C(=O)[C@@H1]4CCN(C)C4)C3)C2)=N1 CC(C)(C)C(C)(C)C(=O)NCCC[C@@H1]1CN(C(=O)CCS(N)(=O)=O)CCO1 CN(C)C1(C(=O)N2C[C@@H1](NC(=O)C3=CN=C4N3CCC4)C[C@@H1](F)C2)CCOCC1 C/C=C/C[C@@H1](CC)C(=O)N(CC)CC(=O)NCC1(C)CC(F)(F)C1 CCN(C[C@@H1](C)NC(=O)C1=CC=NN1CC(F)F)C(=O)CC=C(Cl)Cl C[C@H1](CCC1=CC=CO1)N2C[C@H1](C(=O)O)CCC23CCC3 CCNC(=O)CC(=O)N(CCNC(=O)[C@@H1]1C[C@H1]1OCC)C2CCCCC2 CC1=C(F)C=C(Br)C=C1C(=O)N[C@@H1](C)C[C@@H1](C)C(F)(F)F CCN1CCC[C@H1]1C(=O)N[C@@H1]2CN(C(=O)C3=CC=C(OCOC)C=C3)CC24CC4 CCN(CCCNC(=O)C1CS(=O)(=O)C1)C(=O)[C@H1]2C[C@]2(C)C(C)C O=C(C=CSC1=CC=CC=C1)N[C@@H1](CNC(=O)[C@@H1]2CSCCS2)C3CC3 C=CCNC(=O)[C@H1](C=1C=CON=1)N2CCCC3=C(OC)C=CC=C32 C#C[C@H1]1CCCN1C(=O)[C@H1]2CCN(C(=O)C=C(C)C3=CC=CO3)O2 CC=1C(C(=O)NC[C@](C)(O)CNC(=O)C[C@H1]2COCCO2)=C[NH1]C=1C#N CC[C@@H1](O)[C@H1](C)C(=O)NCCN(C)C(=O)CCC(=O)N(C)C CN(C[C@H1]1COCCN1C(=O)[C@@H1](F)C2CCC2)C(=O)CCN3CCC3 C[C@@H1]1CC[C@@H1](C(=O)N2CCN(CCN(C)C(=O)[C@H1]3C[C@@H1](N4C=NN=C4)C3)CC2)S1 CCC1=NN(C)C=C1C2=CN=CC(NC(=O)C3=CC(Br)=C(C)C=C3OC(C)=O)=C2 CCC[C@H1]1CCCN(C(=O)[C@H1](CC)N(C)C(=O)CCOCC(F)F)CC1 CC(C)C[C@H1](CNC(=O)C=1[NH1]C=NC=1C2=CC=CC=C2)NC(=O)[C@@H1](C)CC(C)C C[C@@H1]1[C@H1](NC(=O)C2=CC=CN3N=NN=C23)C[C@H1]4CC[C@H1]1N4C(=O)CCF CC(C)NS(=O)(=O)CCNC(=O)C1=N[NH1]C2=CC(F)=CC=C12 C/C=C/C[C@@H1](C)C(=O)N[C@H1]1CCC[C@H1]1C(=O)NCCC2=CC=CC(F)=C2 C=C1C[C@H1]1C(=O)NC(CO)(CO)CN(C)C(=O)C2(N3CCOCC3)CC2 C=CCCC(=O)N1CC[C@@]2(CNC(=O)CCCC3=NC=C(C)O3)CCCC[C@H1]12 CN(C(=O)CNC(=O)C1CCC1)[C@H1]2CN(C(=O)C3=CC4=CC=CN=C4[NH1]3)C[C@@H1]2F CC1=NN=C(CC(=O)N[C@H1]2CCC23CN(C(=O)C4=CC=C5OC(O)=NC5=C4)C3)O1 C#CC1=CC=CC(CC(=O)NC[C@@H1](C)N(C)C(=O)[C@H1]2CC[C@H1](OC(F)F)CC2)=C1 CC(C)CC=1ON=CC=1C(=O)N(C)C[C@@H1](C)NC(=O)[C@@H1]2CC3=CC=C(F)C=C3O2 CCOCCS(=O)(=O)NCC(=O)N1CC[C@H1](NC(=O)CCSCC)C(C)(C)C1 COC(=O)NC(C)(C)C(=O)N(C)C[C@@H1]1CCCN1C(=O)[C@H1](CCN(C)C)N(C)C CCN1N=CC(Cl)=C1C(=O)N(C)C[C@@H1](C)CNC(=O)[C@@]23CC[C@H1]2C3 C[C@@H1](C(F)F)N(C)C(=O)C1=CC(CNC(=O)CN2N=CC=N2)=NO1 CS[C@@H1](C)C(=O)N[C@H1]1CC=C(C(=O)NOCC2CCOCC2)C1 C[C@@H1](CCNC(=O)CCC(=O)C1=CC=CS1)NC(=O)C(C)(C)C2=CC=NC=C2 CN1N=C(C(=O)NC[C@]2(F)C[C@H1](NC(=O)C3(C#N)CCSCC3)C2)C=C1Cl C=C(C)[C@@H1](O)CC(=O)N1CC[C@@](C)(CNC(=O)C=2C(C)=NN(C)C=2C(F)F)C1 CCC[C@](C)(O)C(=O)NCC1([C@H1](C)NC(=O)C2=NN(C)C=C2C)CC1 CCC(=O)N1CCN(C(=O)C#CC(C)(C)O)C[C@H1]1CC(F)(F)F C[C@@H1](NC(=O)CCOCCN(C)C)C1(CNC(=O)[C@@H1](O)C2CCOCC2)CC1 COC[C@H1](C)CNS(=O)(=O)C1=CC=C(N2CCN(C)[C@@H1](C(C)(C)C)C2)C(Cl)=C1 C=C[C@]1(C(=O)N[C@H1]2C=CCC[C@H1]2CO)CCN(C(=O)[C@H1](C)OCCOC)C1 CCNC(=O)C(=O)NC[C@@H1]1CCC[C@@H1]2CN(C(=O)CN3C=CC(C)=CC3=O)C[C@H1]21 C[C@H1](O)[C@@H1](C)C(=O)N1CCO[C@@H1]2CCN(C(=O)C3=CC=C(C4CC4)N=C3O)C[C@@H1]21 COC1(C(=O)NC[C@@H1]2CN(C)CCN2C(=O)C3=CN=CC(Cl)=N3)CS(=O)(=O)C1 COC(=O)CN1C=C(C2=CC=C([N+1](=O)[O-1])C=C2C(=O)O)C=N1 CCCN1C[C@H1](NC(=O)[C@H1](CNC(=O)CC[C@H1](C)N(C)C)CC2CC2)CC1=O CCC[C@@H1](C(=O)O)N(C)C(=O)C(N1C=C(C(=O)C2=CC=C(OC)C=C2)N=N1)C CO[C@]1(C(=O)NC[C@H1]2CCN(C(=O)C3=CC(O)=NC(O)=N3)C2(C)C)CCSC1 CC(=O)NC1=C(C)C=CC=C1C(=O)N2C[C@@H1](O)[C@H1](NC(=O)CC3=CSN=N3)C2 CCC1=CC(C(=O)N2CCC[C@](F)(C(=O)NC3CC([C@@H1](C)O)C3)C2)=CC=N1 C=CCCCCCC(=O)N1C[C@@H1](OC)C[C@H1]1CCNC(=O)COC=2C=CSN=2 CCOC(=O)[C@@H1](NC(=O)CC1CCN(C(=O)C=CC(=O)N(C)C)CC1)C2CC2 C[C@H1]1CCS[C@H1]1C(=O)N(CCO)CCCNC(=O)C2CC(C)(C)C(C)(C)C2 CC(C1)CC(=O)N(CC(=O)N2C[C@H1](NC(=O)COC3=CC=CN=C3)C4(CCC4)C2)O1 C=CCCC(=O)N1C[C@H1](NC(=O)C2=CN(C)C(C)=CC2=O)C3(CCC3)C1 CC(=O)C=CC=CC(=O)NC(C)CC(NC(=O)CC1=CC=C(Cl)C=N1)C(C)(C)C CCN(C(=O)C=CC1=CC=CC(F)=C1)[C@H1]2CCN(C3=CC(C(=O)OC)=NC=N3)C2 O=C(N[C@]1(CNC(=O)C=2N=COC=2C3CC3)CCOC1)C4=C[NH1]C=C(F)C4=O C=CCC(=O)N1CCC[C@@](O)(CNC(=O)[C@H1]2CCCC3=CC=CC=C32)CC1 C[C@@H1](C(=O)NCCCCCC(=O)N1CCC([C@H1](C)O)CC1)C(F)(F)C(F)F C[C@@H1](CC1CCN(C(=O)C2=NC=CC=N2)CC1)NC(=O)C3=CC=NC=4C=CSC3=4 CC(C)(C)CC(=O)N[C@@H1]1C[C@@]2(NC(=O)CNC(=O)C3CCOCC3)CO[C@@H1]1C2 C=CCC[C@H1](NC(=O)[C@@H1](O)[C@H1](OC)C(C)C)C(=O)NC1=CC=C(CCF)C=C1 CC(C)OCCCC(=O)N[C@@H1]1CCCC[C@@H1]1NC(=O)COC2CC2 CC(=O)N[C@@H1](C(=O)NCC1=CN(C2=CC=CC(C(C)C)=C2)N=N1)C(C)(C)C COCCC(C)(C)CNC(=O)C[C@H1](CC(C)C)NC(=O)CC1CC(F)C1 C#C[C@@H1]1CCCN1C(=O)[C@H1](CC(N)=O)NC(=O)C=C[C@@H1]2CCCN2C O=C(N[C@@H1]1CN(C(=O)C=2C=C[NH1]C=2)CC[C@H1]1CO)[C@H1]3C[C@@H1]3C4=CC=CN=C4 CN(C(=O)C[C@@H1]1CCN1C(=O)C2=CC(Cl)=CS2)[C@H1]3C[C@@H1]4C[C@@H1]4C3 C[C@@H1]1C[C@@]2(C(=O)N3CC[C@@H1]3CNC(=O)CN4C=C(C(F)(F)F)C=C(Cl)C4=O)C[C@@H1]12 O=C(C[C@H1]1COC(=O)N1)N[C@@H1]2CN(C(=O)CC3=CN=CN=C3O)CC24CC4 CC1=NC(Cl)=NC(NC2(C)CC(NC(=O)[C@@H1](C)C(C)(C)C)C2)=C1F CN1N=CN=C1C2=CC=C(C(=O)N3CCN(C(=O)C(=O)NC4CC4)[C@@H1]5C[C@H1]53)C=C2 CC1=CC(=O)OC(C)=C1C(=O)N2CC[C@]3(NC(=O)C4=NC=CC=C4Cl)C[C@H1]3C2 O=S(=O)(C=1SC=C(Cl)C=1Cl)N2CCN(S(=O)(=O)N3CCCCCC3)CC2 CC[C@H1]1[C@H1](CC(=O)N2CC(NC(=O)[C@@H1](F)C3CCOCC3)C2)C1(F)F CO[C@@H1]1C[C@@H1](C=2N=C[NH1]N=2)N(C(=O)N[C@@H1]3CCC(F)(F)C3)C1 CC(C)C#CC(=O)NC[C@@H1](C)CN(C)C(=O)CN(C)CCC1=CC=CC=C1 CCC=CC(=O)N[C@@H1]1CCC[C@H1](CN(C)C(=O)C2=CC=CN=C2CC)C1 CC[C@](C)(CO)C(=O)N1CC([C@@H1](C)NC(=O)C2=CN=C(OCF)C=N2)C1 COC1=CC(C)=CN=C1C(=O)N2C[C@H1](CNC(=O)CN3C=CN=N3)C[C@@H1]2C CC1(C)CCC[C@@H1](C(=O)N[C@@H1](CN2C=NC=N2)C(=O)NC[C@H1]3CC=CCC3)C1 CC1=NC(C(=O)N[C@H1]2CCN(C(=O)C=3C=C(C4CC4)N(C)N=3)C2)=CC=C1C#N CC[C@H1](C(=O)NCC1(O)CN(C(=O)C2=COC(N(C)C)=N2)C1)[C@H1](C)O CC[C@H1](NC(=O)C1=CC=C(O)C2=CC=CC=C12)C=3C=CN(C)C=3 CSC1=CC=NC(NC(=O)N(C)C[C@@H1](O)C2=CC=C([N+1](=O)[O-1])C=C2)=N1 CCN(C[C@@H1]1CCCCN1C(=O)C[C@H1](C)CC(F)(F)F)C(=O)C=2C=CSC=2C CC1=NOC(C)=C1CC(=O)N2CCN(C(=O)CN3N=CC=N3)C[C@@H1]2CC#N O=C(CCCC(=O)C1=CC=CC=C1)NCC#CCNC(=O)C=2C=CSC=2C(F)F COC[C@@H1](OC)C(=O)N[C@@H1]1CN(C(=O)C2=NC=CN2C(C)C)CC13CCC3 CC=C(F)C(=O)N1C[C@@H1]2CCC[C@]2(CNC(=O)C3=CC=C(OCC)C=C3)C1 CC(C)[C@@H1](CCNC(=O)C1(F)CCC1)NC(=O)[C@H1](C)CF CCN(C[C@H1](C)NC(=O)CCC(F)(F)C(F)F)C(=O)C=1C=C(C(F)(F)F)[NH1]C=1C C[C@@H1]1C[C@H1](C(=O)N2CCC([C@@H1](C)CO)CC2)C1(C)C O=C1CC[C@H1](CCC(=O)NC2C[C@@H1](CN=C3C=C(C4CC4)N=C[NH1]3)[C@H1](C)C2)N1 CC(=O)NCC(C)(C)C(=O)NCC1[C@@H1]2CN(C(=O)C3=C(N)C=CC=C3Cl)C[C@@H1]12 C[C@]1(C(=O)N[C@H1]2CC[C@@H1]2C(=O)N3CCCC[C@@H1]3CCO)CCC[C@H1]1O CC(C)N(C)CCNC(=O)[C@@H1]1CN(C)CCN1C(=O)CNC(=O)[C@@H1]2C[C@H1]2C C=CCC[C@H1](NC(=O)[C@H1]1CN(CC)CCO1)C(=O)NCC=CCl CN(C[C@H1]1CCN(C(=O)C2=N[NH1]C3=C2COC3)C1)C(=O)C=4SN=C(O)C=4Cl CC1=CC(C(=O)N2CC3(CC[C@H1]3CNC(=O)C[C@H1]4CCN(C)C4)C2)=C(N)C(Cl)=N1 CCCOCCCC(=O)N(CC)CCNC(=O)C1(C2=CC=CC(Cl)=C2F)CC1 CC1=CC(CO)=CC(C2=CC=C(NS(=O)(=O)C3=CC(F)=C(F)C(F)=C3)S2)=C1 CCCCCOCC(=O)N1CC[C@@H1]2CCN(C(=O)C=3N=C(C)N(C)N=3)C[C@@H1]21 C=C(CC)CNC(=O)C1(CCNC(=O)[C@H1]2CN(C)C[C@H1](C)O2)CC1 CC1=NOC(CCNC2=CC(N[C@H1]3CCC4=N[NH1]C=C4C3)=NC=N2)=N1 C=CC1(CC(=O)NC2CC(C)(C(N)=O)C2)CN(C(=O)C3=CC=C(OC)C=C3)C1 CCO/C=C/C(=O)N1CCO[C@H1](CC(=O)NC2=CC(F)=CC=C2CC)C1 CC(=O)NC1=CC=C(C(=O)N2CCC[C@H1]2C3(O)CN(C(=O)C4=C(Cl)CC4)C3)C=C1 CC1=CC=C(CCC(=O)NC2CC(O)(CNC(=O)C(C)(C)C(N)=O)C2)C=C1C CN1C=C(C(=O)N2CC[C@H1]3C[C@H1]2CN(C(=O)CCC4CCOCC4)C3)C(O)=NO1 CCN(CCCNC(=O)C1=COC(CO)=C1)C(=O)C2CC(S(C)(=O)=O)C2 CC=1ON=CC=1C(=O)N2CC[C@@H1](C3CC3)[C@@H1]2CNC(=O)CC4=CC(F)=CC=C4F C[C@@H1](CCC(F)(F)F)NC(=O)CC1=CCN(C(=O)CCC=2C=NOC=2)CC1 CC1=CN=CC=C1C=CC(=O)N2CC[C@H1]([C@@H1]3CCN(C(=O)CCC4(C)CC4)C3)C2 CCOCCC(=O)N1CC([C@@H1](O)C(=O)N2C[C@H1](CO)CC23CCC3)C1 CCN1CCO[C@@H1](C(=O)N[C@H1](CC2=CN=CN=C2O)C(=O)O)C1 CC1=CC=C(CC(=O)NC[C@@H1]2C[C@@H1](CNC(=O)CC3=C[NH1]N=C3C)CO2)O1 C[C@@H1]1CN(C(=O)C2=COC3=C2C(=O)CCC3)C[C@H1]1CC(=O)N[C@]4(C)CCSC4 C[C@H1]1C[C@]1(C)C(=O)NCCOCCCNC(=O)C2=CC(N)=C(O)C(F)=C2 C[C@H1](NC(=O)[C@H1]1CC(=O)N(C)C1)[C@@H1](C)NC(=O)CN=C2C=C[NH1]C=C2 CN1CCN(C(=O)[C@@H1](NC(=O)CC2=CC=CC(F)=C2)C3=CC=NN3C)CC14CC4 O=C(CC1=CC=CO1)NC2=CC=CC(NC(=O)CCN3CCOCC3)=C2 C[C@H1]1CCN(C(=O)C(F)=C2CCC2)[C@H1]1CNC(=O)C3=CC=NC(N4CCCC4)=N3 N#CC1=CC=C(C(=O)N2CCC23CN(C(=O)[C@H1]4CC[C@H1](N=[N+1]=[N-1])C4)C3)O1 CC1(C)C(C)(C)C1(C)C(=O)N[C@H1]2C[C@@H1]2CNC(=O)COC3=CC=C(F)C=C3F NC(=O)C1=CC=C(C(=O)NC[C@@H1]2C=[C@H1]CO2)N=C1 CN(CCO)CC(=O)NC[C@@H1](CO)NC(=O)[C@]1(C2=CC=CC=C2)C[C@H1](O)C1 C#CCCCC(=O)NCCCCCN1CCN(C(=O)CCCC/C=C/C)CC1(F)F CCC[C@@H1](CNC(=O)C[C@](C)(O)CCC)C(=O)N1CC(C2=NOC(C)=N2)C1 CCCCC[C@@H1](C)CC(=O)N[C@]1(C)C[C@H1](C(=O)N2CCC[C@H1](OC)[C@@H1]2C)C1 C[C@@H1](C(=O)N(C)CC(C)(C)NC(=O)C1=CC(O)=C2C=COC2=C1)C3CCCC3 C=CC[C@@]1(NC(=O)C2CN([C@@H1]3CCOC3)C2)CCN(C(=O)C4(CC)COC4)C1 CC1=NC(=N)[NH1]C=C1C(=O)NCC[C@H1](O)CNC(=O)[C@H1](C)[C@@H1]2CCC(=O)N2C COCCC[C@@H1](C)NC(=O)CC1(OC)CN(C(=O)[C@H1](C)N2N=CC=C2C)C1 COC1=CC(OC)=C(Cl)C(C(=O)N[C@H1]2CN(C(=O)CC(C)(C)C)CC[C@@H1]2C)=C1 COC1=CC=C(C)C(C(=O)N[C@H1]2C[C@@H1](C)CN(C(=O)CCC3=CC=CS3)C2)=C1 CC[C@@](C)(CCC(C)C)C(=O)N[C@H1]1C[C@H1](NC(=O)CC23COC(C)(C2)C3)C1 CC[C@H1](O)C(F)(F)C(=O)N1CC[C@@H1]2CN(C(=O)C3=CC(OC)=N[NH1]3)C[C@@H1]2CC1 C[C@H1](CCC(=O)NC[C@@H1](CO)CNC(=O)C=CC1CCCCCC1)N(C)C CC=1C=NN(CC(=O)NC2(C)CN(C(=O)[C@]3(C)CCC[C@@H1]3C)C2)C(=O)C=1 CC(C(=O)N[C@H1]1CN(C(=O)C2=CSC(C3=CC=CC=N3)=N2)C[C@H1]1C)=C4CCCC4 C=C(Cl)CN1C(CC2=CC=CC(OC)=C2)=NN=C1N(C)CCOC(C)C CCN1C=CN=C1C(=O)N[C@H1]2C[C@H1]3CC[C@@H1]2N3C(=O)[C@]4(COC)CC4(F)F CCC[C@@H1](C(=O)N(C)C[C@H1](C)NC(=O)C1(CC(=O)NC(C)C)CCCC1)C(C)C CO[C@H1](C)CN(C(=O)C12CC(C3=CC(Cl)=CC(CO)=C3)(C1)C2)C(C)C O=C(C1=CN=C2C=CC=CC2=N1)N3CC[C@H1](N=C4C=CN5N=CC=C5[NH1]4)C3 COC1=C(F)C=CC(N)=C1NC(=O)C2=CSC3=C2CCN(C(=O)[C@H1](C)S)C3 CC1(C)[C@H1](CNC(=O)C[C@]23CCC[C@H1]2C3)CCN1C(=O)C=4C=CC5=CN=NN5C=4 C=CCCOCC(=O)N[C@H1]1CC[C@@H1]1NC(=O)C(C)(C)OC2=CC=C(Cl)C=C2C CCC1=CN=C([C@H1](C(=O)NC2CCOCC2)N3C[C@H1]4CCS(=O)(=O)[C@H1]4C3)S1 CN(C1=NC(Cl)=NC(C2CC2)=C1F)[C@@H1]3CCN(C(=O)CN4CCC(=O)NC4=O)C3 CC1=CC(C(=O)N[C@H1]2CCCC[C@H1]2CNC(=O)C3CC4(CC(O)C4)C3)=CC=C1O C=CCNC(=O)[C@H1](C1=CC=C(OCCN2CCCCC2)C=C1)N3CCSC[C@H1]3C CC[C@](C)(CO)C(=O)N1C[C@H1](NC(=O)C2=CC=C(OC(C)C)C=C2)C(C)(C)C1 O=C(CC1=CC=C2C=CC=CC2=C1Br)N[C@H1]3CC(=O)N(CC4=CC=CS4)C3 C=CC=CCC(=O)NCC1=CC(C(=O)N2C[C@]3(CO)C[C@]3(CO)C2)=CC=N1 COCC(=O)N1CCC[C@H1]1C(C)(C)NC(=O)CC2=CC(O)=NC(O)=N2 C[C@@H1](CN(C)C(=O)CN1N=C(O)C=CC1=O)NC(=O)[C@@H1]2CCCS(=O)(=O)C2 CCCC(C)=CC(=O)N1CCN2N=CC(CNC(=O)[C@@H1](F)CC)=C2C1 CCC1=CC=CC=C1[C@@H1](CNC(=O)[C@@H1]2CCC(=O)N2)NC(=O)CN(C)C(C)C C#CC1=CC=CC=C1CC(=O)N2CC[C@H1](C(=O)N3CCCSCC3)C2(C)C CNC(=O)[C@H1](C=1C=COC=1)N2CC[C@H1](N3CCCC3)[C@@H1](C)C2 COC1=CC=C(C(=O)N2CCC[C@H1]3CN(C(=O)C=CC(C)=O)CC[C@@H1]32)C=C1 CC1=CN2C(C(=O)N3CC[C@H1]4CC[C@@]43CNC(=O)CCCCC#N)=CN=C2S1 O=C(C1=CC=C(O)C(O)=C1)N2CC3(CC[C@H1](NCC4=CC=C(Cl)S4)C3)C2 CSC1=CC=C(C(=O)N2CCC[C@@](F)(CNC(=O)[C@H1](CC=3C=CSC=3)NC=O)C2)O1 C=CC(C)(C)C(=O)N(C)C[C@H1](O)CN(C)C(=O)C[C@]1(O)CCCN(C)C1 CCOCC(=O)NCC[C@@H1](C)NC(=O)C=1C=C2N=CC(Br)=CN2N=1 CCC[C@H1](C)CC(=O)N[C@@H1]1CN(C(=O)C2(C(=O)N(C)C)CC2)CC(C)(C)C1 CC(C)CSCCC(=O)N[C@@H1](CNC(=O)C1=N[NH1]C=C1[N+1](=O)[O-1])C(C)C CN(C(=O)C=1C=NN(C[C@@H1]2CCCCO2)C=1)[C@@H1]3CCC4=CC(Br)=CC=C4C3 CCNC(=O)CCNCC1=CN=CN1C2CC2 C[C@@H1](CC(=O)N1CCC=2SC(CNC(=O)C=C3CCN(C)C3)=NC=2C1)C(F)F CCC(=O)NC12CC(CNC(=O)C3=CC(N)=C(O)C=N3)(C1)OC24CCC4 C[C@@H1]1CN(C(=O)[C@](C)(F)C=2C=CON=2)C[C@H1]1NC(=O)CN3N=CC4=CC=CN=C43 CC=1SC([C@@H1](C(=O)NC[C@@H1]2CCOC2)N(C)CC3=CSC=N3)=CC=1Br COCC1(CNC(=O)CCCCNC(C)=O)CCN(C(=O)[C@H1](O)CC(F)F)CC1 C[C@H1]1CN(CC2CCC(C)(C)CC2)CCCN1CCO O=C(N=C1[NH1]N(C2=CC=C(Cl)C=C2Cl)C=C1O)N[C@H1]3C[C@@H1]4CSC[C@@H1]4C3 C#CC[C@H1]1CCN(C(=O)[C@@H1](C)N(C)C(=O)CCC(=O)NCCC)C1 COC(=O)C1=CC=C(C(=O)NC[C@@H1](CO)CNC(=O)C2(C(F)F)CC(F)(F)C2)S1 C=CC1(C(=O)NCC[C@H1]2CCCCN2C(=O)CCCC(C)=O)CCC1 CC(C)[C@H1]1C[C@H1](C=2N=N[NH1]N=2)CN(C(=O)C=3ON=C4C=3CCCC4)C1 CC[C@H1](CN(C)[C@@H1](C(=O)NCCOC)C1=COC(Br)=N1)NC(=O)OC(C)(C)C CC[C@H1](COCC(F)(F)F)NC(=O)COC=1C=CON=1 C[C@@H1](CF)C(=O)N1[C@H1](CNC(=O)CCNC(=O)C=2C=CSC=2)C[C@@H1]3C[C@@H1]31 CC(C)[C@H1](C)[C@@H1](CNC(=O)C1=CON=C1C2CC2)NC(=O)C3=CC=C(N)C=C3O CCN(C(=O)CCNC(C)=O)[C@@H1]1CCN(C(=O)[C@@H1]2C[C@@H1]2C3=CC=CC=C3)C1 CN(C)C1=CC=C(C(=O)N2[C@H1](CNC(=O)C3=CC=C(F)O3)C[C@@H1]4C[C@@H1]42)N=N1 CC(C)(C)[C@H1](CNC(=O)[C@@H1]1COC(=O)C1)NC(=O)CN2C(=O)CNC2=O O=C(N[C@H1]1C[C@]12CCN(C(=O)C3=C[NH1]C4=CC=CN=C34)C2)C5=C[C@H1]6C=C[C@H1]5C6 COC1(CNC(=O)[C@H1](C2=CSC=N2)N(C)C)CN(C(=O)C=CCN3C=NC=N3)C1 COCCSCC(=O)N1CCN(C(=O)CCN2C=CC(C)=N2)C[C@@H1]1C3CCC3 CCN(CCNC(=O)[C@@H1]1C=C1C)C(=O)CSCC2=CC=NC=C2 CC1=NSC(N2CC([C@H1](C)NC(=O)C3=CC=NC(C4CCC4)=C3)C2)=N1 C[C@H1](CNC(=O)C1C[C@@H1]2CC[C@H1](C1)O2)N(C)C(=O)C3=CC=C(N4C=NN=N4)C=C3 CC[C@H1](C(=O)N1C[C@H1]2CCN(C(=O)C3=CC4=C(N=N3)CCC4)C[C@H1]2C1)C(C)(F)F O=C(CC1CC1)N[C@@H1]2CCCN(C(=O)[C@@H1]3CCN4CCOC[C@@H1]34)CC2 CCCCC(=O)NC[C@@H1]1CCC[C@H1]2CN(C(=O)C3=COC(SC)=C3)C[C@@H1]12 CC[C@H1](C(=O)N[C@@H1]1CN(C(=O)C2=CC=C(C3CC3)C=C2)C[C@H1]1C4CC4)C(F)(F)F O=C(N1CCC(CCOCC2CCC2)CC1)C3(N4C=CC=N4)CCC3 CC(C)C1(N)CCNC[C@@H1]2COC[C@]2(C(=O)NCCC(=O)OCC3=CC=CC=C3)C1 C#CC[C@]1(C(=O)N[C@H1]2C[C@H1](NC(=O)[C@@H1]3C[C@H1](C)O[C@H1](C)C3)C2)CCCO1 C#CCNC(=O)CC(=O)N1CC[C@H1]2CCC[C@@]21C(=O)NCC3(CCO)CCCC3 CO[C@]1(C)C[C@H1](NC(=O)[C@@H1]2CN(C(=O)[C@H1](O)C3=CC=CO3)C[C@H1](C)O2)C1(C)C CC(C)N1C=CC(CC(=O)NC2CC(C)(NC(=O)CC3(O)CCCCC3)C2)=N1 C[C@@H1]1C(=O)N(C(=O)CCCCCO)CC[S@@](=O)C1(C)C C#CCCCCC(=O)N1CCCC[C@@]2(CCN(C(=O)C(F)(F)[C@H1](O)C3CC3)C2)C1 CN(CCN1C=C(Cl)C=N1)C(=O)NC[C@](C)(O)C=2C=NN(C)C=2 CCC[C@@H1](C(=O)N[C@]1(C(=O)N(C)[C@H1]2CCOC2)CCN(C)C1)N(C)C C[C@@H1](C(=O)N[C@@H1]1C[C@H1]2CC[C@@H1]1[C@@H1](NC(=O)CN3CCCCCC3=O)C2)S(C)(=O)=O CCN(CC(=O)N1CC[C@H1](C)[C@@H1](NC(=O)[C@H1]2CC3CCC2CC3)C1)C4CC4 C=CC[C@@H1](C(=O)N(C)C[C@H1]1CCCCN1C(=O)C2=CC3=C(O2)CCCC3)C(C)C C#CC[C@H1](C)C(=O)N1[C@H1]2CC[C@@H1]1C[C@@H1](NC(=O)C3=NOC(C4CC4)=C3C)C2 COC1=C(C(=O)N[C@@H1](CC(C)C)CN2C=C(C3(O)CSC3)N=N2)SC(Cl)=C1Br C[C@]1(CNC(=NCCF)NC[C@H1]2C[C@@H1](N(C)C)C2)CCOC3(CCC3)C1 O=C(C1=CCCS1)N2CCCC3(CCN(S(=O)(=O)C4=CC=CS4)CC3)C2 CC1=CC=C(O[C@@H1](C)C(=O)N2C[C@@H1]3CC[C@H1](C2)N3CC=4C=C(C)ON=4)C=C1 O=C(CC1CSC1)N[C@@H1]2C[C@@H1](C(=O)O)C[C@H1]2N3C=C(C4=CC=C(Cl)C=N4)N=N3 C[C@@]1(CNC(=O)C2=CN3C=NN=C3C=N2)CC[C@@H1](NC(=O)CC4(C5CC5)CC4)C1 C[C@@H1]1CC[C@H1]1N(C)C(=O)[C@@H1]2CC[C@H1](CNC(=O)CCCCN(C)C)C2 CSCCCN(C)C(=O)C1=N[NH1]C2=C1CN(C(=O)[C@@]3(O)CCOC3)C2 CN(C(=O)C1(S(N)(=O)=O)CC1)[C@@H1]2CN(C(=O)COC3(C)CCC3)C[C@H1]2F CCCC[C@H1](C)C(=O)N1C[C@@H1]2C[C@H1](C1)[C@H1](NC(=O)C[C@@H1]3CCC(F)(F)CO3)C2 COCC[C@H1](C)C(=O)NCC[C@@H1]1CCN(C(=O)C=2C=NN3C=2OCC3)C1 CC(C)[C@H1](NC(=O)[C@H1]1CCC2=C[NH1]N=C21)C(=O)NC[C@H1](O)C(C)(C)C CC(C)(C)C(=O)NCCC(=O)N[C@]1(C)CCCN(C(=O)CC[C@H1](C)C#N)C1 CN1C=C(C[C@H1](O)C(=O)N2CC[C@@H1](CCNC(=O)CC3CSC3)C2)C=N1 CCC(C)(CC)C(=O)N[C@@H1]1CCN(C(=O)C2=CN=C(S)N2C)C[C@H1]1C(C)C C[C@H1]1CCCC=C1C(=O)N2CC[C@H1]3CC[C@@H1](C2)N3C(=O)C=4C=CC(=N)[NH1]C=4 C[C@@H1]1CN(C(=O)C[C@H1]2CC[C@@H1](C3CC3)O2)CCN1C4=NC=NC5=CC=CN=C45 CN(C[C@H1]1CCN(C(=O)C2=CN=CC(Br)=C2)C1)C(=O)[C@H1]3C[C@H1]3C(=O)OC(C)(C)C CSC(C)(C)C(=O)NC[C@](C)(O)C1CCN(C(=O)C2=CN=C(C(C)(C)C)[NH1]2)CC1 O=C([C@@H1]1CCCN1CC2=CC=C3C(=C2)OCCCO3)N4[C@H1]5COC[C@H1]4CC(F)C5 O=C([C@@H1]1CCN(CCO)C(=O)C1)N(CCO)CC(F)F N#CC1=C[NH1]C(C(=O)NC[C@@H1]2C[C@H1](C(C)C)CCN2C(=O)C3=CC(Cl)=C(Cl)[NH1]3)=C1 CC[C@H1](C(=O)NCC1(CO)CCN(C(=O)C(SC)SC)CC1)N2CCCC2=O CN(CCNC1CN(C(=O)/C=C/C=C/C2=CC=CC=C2)CC1)C(=O)CP(C)(C)=O COC1=NOC(C)=C1C(=O)NC[C@H1](CC2CC2)C(=O)NCC(C)(C)C3CC3 CNC(=O)N[C@H1](C)C(=O)N[C@@H1](C)[C@H1]1CN(C(=O)C2=CC=C(F)C(Cl)=C2F)CCO1 CC=1[NH1]C=CC=1C(=O)N2C[C@@H1](O)[C@@H1](O)[C@@H1]2CNC(=O)C3CC(Cl)(Cl)C3 CC1=CC=C(O[C@H1](C)CNC2=NC=CC(N3CC[C@@H1](C)C(C)(C)C3)=N2)C=C1 C[C@H1](NC(=O)C1=CC=CC=N1)C(=O)NCCC(N2C=CC(C(F)(F)F)=N2)CC CO[C@@H1]1C[C@H1](CNC(=O)CN(C)C2=NC=CC=N2)N(C(=O)C3=CC=C(C#N)S3)C1 CC[C@@H1](C)/C=C/C(=O)N1CC[C@@](C)(NC(=O)C2=CC(F)=CC=C2Br)C1 CC1=NSC=C1C(=O)NC2CC(CNC(=O)C3CCN(C4=CC=NC=N4)CC3)C2 CC(=O)CCCC(=O)N1CCCC[C@H1]1[C@@H1]2CCN(C(=O)C3=CC(F)=CC=C3N)C2 C[C@@H1](O)C(=O)N1C[C@@H1](NC(=O)C=2C=C(C3CC3)OC=2C4CC4)CC1(C)C CCC(=CC(=O)N1C[C@H1](C)[C@H1](CNC(=O)C2=CC=C3C(=C2)C(=O)NC3)C1)CC CC=1N=C(Br)OC=1C(=O)N2CC[C@H1]([C@@H1](C)NC(=O)C3=CC=CC=[N+1]3[O-1])C2 CC1=CC(C(=O)N2C[C@H1](NC(=O)[C@@]34CC[C@@H1](C3)O[C@@H1]4C)C[C@H1]2C)=CC=C1[N+1](=O)[O-1] CC1=CC(Cl)=CC(C(=O)NCC23CCC(CC2)N(C(=O)C4=CC=NS4)C3)=C1N COC1=CC=CC(O)=C1C(=O)NC[C@]2(C)CCCN2C(=O)[C@H1](C)CCO CO[C@H1](C)CNC(=O)[C@@H1](CC(F)F)NC(=O)C1=NC(=N)C=C[NH1]1 O=C(C1CC(N2C=C(C3=CC=CN=C3F)N=N2)C1)NC4(C5CC5)CC4 CO[C@H1](CNC(=O)[C@@]1(O)CCOC1(C)C)CC(=O)NCC=CC2=CC=CC=C2 CC1=CC(OCC(=O)N2CC(C)(NC(=O)C[C@H1]3CC=CCN3C)C2)=CC(C)=C1Cl CCCN1C=CN=C1CN[C@@H1]2CC=3CCOC=3C2 CCN1N=NC2=C(N3CC[S@](=N)(=O)C(C)(C)C3)N=CN=C21 COC1=CC(N(C)C)=CC=C1C(=O)NC[C@@]2(C)CCCN(C(=O)[C@H1](C)CC#N)C2 O=C(NCC1CCOCC1)[C@@H1](C2=CC=CC=3N=C[NH1]C2=3)N4CCCN5CCC[C@H1]45 O=C(CN1CCCC[C@@H1]1C[C@@H1](O)C2=CC=CC=C2)[C@@H1]3CCCCO3 CC[C@@H1](CNC(=O)[C@@]1(C)CCOC1)NC(=O)C=2C=C(C)N(C3=CC=NC=C3)C=2C CCCOC1=CC=C(CCC(=O)NC[C@H1](C)N(C)C(=O)C2=CCSC2)C=C1 C[C@]1(CC(=O)N2CC[C@](F)(C(=O)NCC(F)(F)Cl)C2)CCOC1 O=C1C[C@H1](CC(=O)N2C[C@@H1]3C[C@]3(CNC(=O)C4=CN=CC5=CC=CC=C45)C2)CO1 CC=1N=NN(CC(=O)NC[C@H1]2CCCN(C(=O)C3=CC(F)=C(C#N)C(F)=C3)C2)N=1 CC1=CC(NC(=O)N2CCC[C@H1]3CN(C)CC[C@H1]32)=CN=N1 O=C(NC[C@@H1]1CCCN1C(=O)C2=CN=C(O)C(Cl)=C2)C3=CC4=CC=CN=C4[NH1]3 O=C(CCCCF)N[C@@H1]1CS(=O)(=O)C[C@@H1]1NC(=O)C2=CC(Cl)=NN=C2O CCCC=C[C@H1](O)C(=O)N(CCC)CCNC(=O)C1=CC=C(Cl)O1 CC[S@](=O)CC(=O)N1CCC[C@H1](N2CCN(C(=O)[C@@H1](F)C(F)(F)F)CC2=O)C1 CCCOCCC(=O)N(CC)CCNC(=O)C=1[NH1]C2=CC(Cl)=CC(Cl)=C2C=1C CCCC1C(CN(C(=O)C2=CCC2)CC1)C3CC3 CC1=CC=C(CCCC(=O)NC[C@H1](CC(C)C)NC(=O)CCCN2C=NC=N2)S1 O=C(N[C@]12CC[C@H1]1CN(C(=O)COC3=CC=CC=C3Br)C2)C4=CC=NC=C4 CNC(=O)[C@@]1(C)CCN1C(=O)[C@H1]2C[C@H1](O)[C@@H1](NC(=O)C=C3CCCCC3)C2 CC1=NOC(C)=C1CC(=O)N2CC[C@H1]2C(=O)NCCOC3=CC=C(F)C=C3 O=C(O)[C@H1]1[C@@H1](C2=CC=CC=C2)[C@H1]1C3=CC=CC4=CC=CN=C34 C[C@H1]OC1(CNC(=NCCCN2CCOC2=O)N[C@@H1]3CCC4=CC=CC=C4C3)CC1 C[C@H1](CC(C)(C)C)C(=O)NC[C@@H1]1CCCN(C(=O)C=2C=CC3=CN=NN3C=2)C1 CCC1=CC(C(=O)N[C@@H1]2CC[C@H1]2CNC(=O)[C@@H1]3CNC(=O)CC3(C)C)=NC=N1 CC1(C)CCCN(C(=O)C2CCC(F)CC2)[C@@H1]1C(=O)NCC3=NC=CC=C3Cl C[C@@H1](C(=O)N(CC(=O)NCCCCCCN=[N+1]=[N-1])C1CC1)C=2C=CN(C)N=2 C[C@H1]1C[C@H1](NC(=O)CCC2=NC3=CC=CN=C3[NH1]2)CCN1C(=O)[C@H1]4C[C@@H1]5C[C@@H1]5C4 C=CCO[C@H1](C)C(=O)N1CCC[C@](C)(NC(=O)C=CC2=CC=C([N+1](=O)[O-1])C=C2)C1 CC1(C(=O)N2C3CCC2(CNC(=O)COC4=CC=C(F)C=C4)CC3)CSC1 C[C@H1](CCC(=O)N[C@H1](C)CC1=CC=CN=C1)NC(=O)C2(F)CCOCC2 CC=CCC(=O)NC1CC2(C1)CN(C(=O)[C@H1](F)C3=CC=C(F)C=C3)C2 CC1=CC=CC(O)=C1C(=O)NCC(C)(C)NC(=O)COC2=CC=C(Cl)C=C2 CC[C@H1](CNC(=O)C1=CN=C(C)C(C)=C1)NC2=NC=CC=C2C(=O)OC CCC=1N=C(C)OC=1C(=O)N2C[C@@H1](CNC(=O)[C@H1]3CN(C)CCO3)OC(C)(C)C2 CC[C@@H1](C#N)C(=O)NCC12CCC(CC1)N(C(=O)CCC(=O)NCC(F)(F)F)C2 CC1=C[NH1]C=C1C(=O)N2CC[C@@H1]([C@@H1](C)NC(=O)CCSC3=CC(F)=CC=C3F)C2 CC[C@@H1](CC(=O)NC[C@H1]1CCC[C@@H1]1NC(=O)C2=CC(F)=C(C)C=C2F)C(C)(C)C CC[C@H1](SC)C(=O)N1CC(C)(C)C[C@H1]1CC(=O)N2CCC[C@@H1](N3CCC3)C2 C=C[C@@H1]1C[C@H1]1C(=O)NCCCOCCNC(=O)C=2C=NN(C)C=2S(N)(=O)=O C[C@@H1](C(=O)N1[C@H1]2CC[C@@H1]1[C@H1](C(=O)N3CC[C@](C)(O)C3)C2)C4CCC4 CC[C@H1]1OCC[C@H1]1C(=O)N(C)CCCNC(=O)C2(S(=O)(=O)NC(C)(C)C)CCC2 O=C(NC1=CC=NC(Cl)=C1I)C=2C=CC3=NC=C(C4=CC=C(F)S4)N3C=2 CN(CCNC(=O)CSC[C@@H1]1CCCO1)C(=O)C2=C(Cl)CCOC2 CC1=CC=2N=CN(CC(=O)N[C@@H1]3CN(C(=O)CCCF)CCC3(C)C)C=2C=C1C CC[C@H1](O)C(C)(C)C(=O)NCC[C@H1](OC)C(=O)N[C@@H1](C)C1=NC=C(C)C=N1 C[C@@H1](OC1=CC=CC(CO)=C1)C(=O)N(C)C[C@H1](O)CN(C)C(=O)C2(CO)CCC2 C#CC1=CC=C(C(=O)N[C@H1]2CCC[C@H1](NC(=O)CCCSC)C2)N=C1 CCC[C@]1(NC(=O)[C@H1](C)C2=CC=CO2)CCCN(C(=O)CCOCCOC)C1 CCC1=CC=C([C@@H1](CNC(=O)CCC(=O)NN(C)C)N(C)C)C=C1 C#CC1(C(=O)NC23CC(F)(C2)C3)CCN(C(=O)C[C@](C)(O)CCC)CC1 CC1=CC(C)=NC(C(=O)N2CC(C)(NC(=O)C3=CC=C4C=CC=CC4=C3C)C2)=C1 C#CCOCCN(C)C(=O)[C@@H1]1CC[C@H1]1NC(=O)CC2=CSN=N2 CC1=CC=CC2=CC(C(=O)N[C@@H1]3CCN(C(=O)C=4C=CSC=4)C[C@@H1]3F)=CN=C12 CC(C(=O)NC[C@H1]1CN(C(=O)C2=CC3=C(S2)CCS(=O)(=O)C3)C[C@@H1]1C)=C4CC4 O=C1N[C@@H1](C(=O)N2CCCC[C@H1](CN3C=C(C4(CCO)CC4)N=N3)C2)CCO1 CC[C@@H1](C)N1N=C(C(=O)N2CCN(C(=O)C(F)(F)CC3CC3)C[C@H1](O)C2)C=C1C O=C(N[C@@H1]1CCN(C(=O)C23CC(F)(C2)C3)CC[C@@H1]1CO)C4=CC=C(Cl)C(F)=C4 CCSC1(C(=O)N[C@@H1]2CCN(C(=O)C3=CC4=CSC=C4S3)CC2(C)C)CC1 C[C@@H1](CC(=O)N1CCC[C@@H1](NC(=O)C2=CC=C(Cl)C(Cl)=C2N)CC1)CN(C)C O=C(NCCC1CN(C(=O)CN2CCS(=O)CC2)C1)C3=C[NH1]N=C3C=4C=COC=4 CCOC(=O)[C@H1](NC(=O)CN1[C@@H1](C)CC[C@H1]1C)C2=CC=C(Cl)C=C2 O=C(NCC[C@@H1]1CN(C(=O)C2=CC=C(F)C=N2)CCO1)C3=CC(O)=C(O)C(Cl)=C3 CO[C@H1](C)CCC(=O)N1C[C@H1](F)[C@@H1](C(=O)N(C)[C@H1]2CCN(C)C2)C1 CC1(C)CC(C(=O)NC[C@]2(C)CCCN2C(=O)CN3C=C4C=CC=CC4=N3)=NO1 C#CCC1(C(=O)OC)CCN(C[C@H1](C)C2=CC(Br)=CC=C2OC)CC1 CCC1=NC(C(=O)N2CCC[C@H1]2CNC(=O)[C@@H1]3[C@H1]4CC[C@]5(COC(=O)[C@H1]35)O4)=CS1 CC(C)(C)[C@@H1](C(=O)NC[C@@H1](CO)CNC(=O)C(F)(F)C1(O)CCC1)C2CCC2 O=C(N[C@H1]1CCN(C(=O)C=CC(=O)N2CCOCC2)C[C@H1]1)C3=CC(F)=CC=C3F C#CC[C@@](C)(NC(=O)C1=CC=CO1)C(=O)NC[C@H1]2NC(=O)OC2(C)C C[C@@H1](O)C(F)(F)C(=O)N1CCOC2(CCN(C(=O)[C@H1]3CC34CC4)CC2)C1 CCC1=NC(C)=C(C(=O)N[C@H1](CCF)C(=O)NC2CC3(CCCCC3)C2)O1 CN(C)[C@H1]1CN(C(=O)C2=CC=CC=C2CN3C=C([C@@]4(C)CCCO4)N=N3)C[C@@H1]1F CC1=CC(=NC(=O)N2CCC(CNC(=O)C(F)(F)F)CC2)[NH1]N1CC(F)(F)F CCOC=CC(=O)N1CCCC[C@@H1]1[C@@H1](C)NC(=O)C(C)(C)CNC(C)=O CC[C@H1](C)N(CC)C(=O)C=1C=NN(C2=CC=C(F)C=C2)N=1 CC1=C(C2=CN(C[C@@H1]3CCN(C(=O)C4=CSC(C5CC5)=N4)C3)N=N2)C=NN1C CC1=CC=C(F)C(N2C=C(CCC(=O)N3C[C@H1]4CC=CC[C@H1]4C3)N=N2)=C1 CC(C)CN1N=C(C2=CC=NN2C)N=C1[C@@H1](C)O[C@H1](C)C3=CC=C(C)C=C3 CC(C)CC1=NC=CC(C(=O)N[C@@H1]2C[C@@H1]3CC[C@H1](C2)N3C(=O)C[C@H1]4C=CCC4)=N1 C#CCCCCC(=O)N(C)[C@H1]1[C@@H1]2CN(C(=O)C3=CC(C#N)=CN3C)C[C@@H1]21 C#CCCCC(=O)N1CC[C@@](O)(C(=O)NC2=CC=C(C)N=C2Cl)C1 CCN1CC[C@@H1](N(CC)C(=O)[C@@H1](C)N2C=C(C(C)(C)NS(C)(=O)=O)N=N2)C1 C[C@@H1](CC(N)=O)C(=O)NC[C@H1]1CC2=CC=CC=C2CN1C(=O)CN3CCOC3=O CN1C(=O)CC[C@H1]1C(=O)N2C[C@H1]3C[C@H1](NC(=O)C4=NC=C(Cl)N=C4Cl)C[C@H1]3C2 CN(CC(=O)N1CCC(C)(C)[C@H1]1CNC(=O)[C@@H1]2CCCC3=CC=CN=C32)C(N)=O CN(C)C1=CC=CC([C@@H1]2C[C@H1]2C3=NC(CCSCC4CCC4)=NO3)=C1 CC(C)=C(C(=O)N[C@@H1]1C[C@@H1]1CNC(=O)C(C)(C)C(C)(F)F)C2=CC=CC=C2 CC1=C(C(=O)N2CCN(C(=O)CN(C)C)[C@H1](C)C2)C=CC3=C1CCC3 CC1=NOC=C1CCC(=O)N2CC[C@H1](NC(=O)C3=CC=CC=N3)[C@@H1](O)C2 COC1=CC=C(Br)C=C1C2(C(=O)N[C@@H1]3C[C@H1]3NC(=O)CC4CCCCC4)CC2 CC1=CC(F)=CC(CC(=O)NC[C@@]2(C)CC[C@@H1](NC(=O)C=3C=NN(C)C=3Cl)C2)=C1 CC(C)[C@]1(C(=O)N2CCN3C=NC=C3C2)CCN(C(=O)C[C@H1]4CCCC(=O)C4)C1 CC=CCC(=O)N1CC2(CC[C@@H1](CNC(=O)CC3=CC=NC(Br)=C3)O2)C1 CC=1ON=C(CO)C=1C(=O)NCC2(CCNC(=O)CCCCN(C)C)CC2 CC[C@H1]1CCN(C(=O)[C@H1](C(C)C)N2C=NN=C2)[C@@H1](C(=O)NCCOCC(N)=O)C1 C[C@@](CO)(CNC(=O)C1=CC2=C(N=C1O)CCCCC2)NC(=O)COCC3CC3 CO[C@H1](C(C)C)[C@@H1](O)C(=O)N1CC=C(C(C)(C)C(=O)N[C@@H1]2CC[C@H1]3CC[C@H1]32)C1 COC[C@@H1](C)C(=O)N(C)[C@H1]1CC[C@H1](CNC(=O)[C@@H1]2C[C@H1]2C(C)(F)F)CC1 CC[C@H1](CNC(=O)C1=CN=C2[NH1]N=CC2=C1)NC(=O)C3=CC(Br)=N[NH1]3 COC1(C(=O)N2CCC([C@H1](O)CNC(=O)[C@H1](C)[C@@H1](C)O)CC2)CC1 CC(C)CCSC1=CC=C(C2=CC=NC(C(=O)NC3=CC=C(CO)C=C3)=C2)C=C1 CO[C@@]1(CN2N=NN=C2NC[C@H1](O)C[C@@](C)(O)C3=CC=CC=C3Br)CCSC1 CC(C)C1=CC=CC(OCC(=O)N[C@H1](C)C[C@@H1](C)NC(=O)CC(=O)N(C)C)=C1 CO[C@@H1]1CN(C(=O)[C@@H1](C)CF)C[C@@H1]1NC(=O)C2=CN=C(C)C=C2Cl CC=1C=CN(C2=CC=C(C(=O)N[C@H1]3COC[C@H1]3NC(=O)[C@H1](C)C4CCC4)C=C2)N=1 C=C(C)CCC(=O)NC[C@H1](NC(=O)[C@@]12CC=C[C@@H1](C1)OC2)C3CCC3 CC(C)CN1N=CC=C1C(=O)NCC2[C@@H1]3CN(C(=O)CNC(=O)C(C)(C)C)C[C@@H1]32 CCN1N=C(C(=O)N(C)C[C@H1](C)NC(=O)[C@@]2(C)CCC[C@@H1]2C)C=C1C O=S(=O)(NCC=1C=NC2=NC=CN2C=1)C3=CC=C(N[C@@H1](CO)CC4CC4)C(Br)=C3 COC1=CC=CC=C1[C@@H1](C)NC(=O)CNC(=O)C2=NN(C)C3=CC=CC=C3C2=O C[C@H1](O)C1=CN(CC(=O)N2CCC3(CC2)CN(C(=O)[C@H1]4C[C@H1](O)C4)C3)N=N1 C=C(CCNC(=O)CCN=C1[NH1]C=CS1)CNC(=O)C2=CSC(CO)=N2 C#C[C@@H1](NC(=O)CCOC1CN(C(=O)[C@H1]2CC=CCC2)C1)C(C)(C)C CCC[C@H1](NC(=O)[C@@H1]1CC[C@@H1]1C)C(=O)NC2=CC=C(O)C=C2F CC(C)(C#N)CCCC(=O)N1CC2(CCC2)C[C@H1]1CNC(=O)[C@H1](F)N3C=CC=N3 CC(C)[C@H1](C)[C@H1](CNC(=O)C(F)(F)C(F)F)NC(=O)C1=CSC(O)=N1 CSCC1(CNC(=O)[C@@H1](CN2C=CC=N2)NC(=O)C3=C(C)OCCS3)CC1 C=CCC(C)(C)CC(=O)N1CC(C)(NC(=O)[C@H1]2CC3=CC=CC=C3C(=O)O2)C1 CCN(CCNC(=O)C1CN(CC(F)(F)F)C1)C(=O)[C@](C)(OC)C2CC2 C#CCCCOCC(=O)N[C@@H1]1CC(=O)N(C2CN(C(=O)[C@H1](C)OCC)C2)C1 CN1C(=O)N(C)C2=CC(C(=O)NC3CCC4(CCCC4)CC3)=CC=C21 C=CCN=C(NCCN(C)C1CC1)N(C)CC2=CC=C[NH1]2 C#CC1=CC=C(CC(=O)NCC2=CCN(C(=O)[C@@H1]3NC(=O)C[C@@H1]3C)CC2)C=C1 CCC1=CC=CC=C1C(=O)NC[C@@](C)(NC(=O)C2=CC=C(C)N=C2C)C3CCC3 COC1=CC=CC(S(C)(=O)=O)=C1N2N=C(CCCO)N=C2CC3=CC=CO3 C[C@H1](O)CN(CCO)C(=O)[C@H1]1CCC(C)(C)N(C(=O)[C@@H1]2CC3=CC=CC=C32)C1 CC/C=C/C[C@H1](C)C(=O)N[C@@H1]1CCCC[C@H1]1NC(=O)[C@@H1](F)C2CCC2 CN1CCC[C@H1]1C(=O)N2CCN(C(=O)CSCC3=CC=CC=N3)[C@H1](CCO)C2 CCC(=O)N1C[C@@H1](NC(=O)C2=CN=NS2)[C@H1](C3=CC=C(F)C=C3OC)C1 CC1=CC(OCC(=O)N[C@H1](CCC(C)C)C(=O)NC[C@H1]2CCC(=O)NC2)=NO1 COC[C@H1](C)CC(=O)N[C@H1]1CN(C(=O)CCOC2=CC=CC=C2F)CC13CCC3 C=CCC1(C(=O)N[C@@H1]2C[C@H1](CNC(=O)C3CN(C(N)=O)C3)C2(C)C)CC1 CCC1=CC=C(C(=O)NC[C@H1](CC)NC(=O)C2=CC(C3CC3)=NN2CC)C(C)=N1 CCCOCCCC(=O)NC[C@@H1](CCNC(=O)CCSC1=NC=CN1C)OC CC[C@]1(C(=O)NN2C=NN=C2)CCN(C(=O)C3=C[NH1]N=C3Cl)C1 C#CCC[C@H1](NC(=O)[C@@H1]1COC(=O)N1)C(=O)N2CCOC(C)(C)CC2 CS[C@H1](C)CC(=O)N(C)[C@H1]1CCN(C(=O)C=2C=CC3=CN(C)N=C3C=2)C1 COC1=CC(CC(=O)NCCC2CCN(C(=O)C3=CC=C(Cl)O3)CC2)=CC=C1Cl COCC[C@@]1(NC(=O)C2=CC=CC(C)=C2OC)CCN(C(=O)C3=CC=NN3C)C1 CC1=CC(C(=O)N[C@@H1]2CC[C@H1]3C[C@H1]2CN3C(=O)/C=C/C4CCCCC4)=NN=C1C C[C@H1](C(=O)N[C@H1]1CN(C2=NC=C(C#N)C=C2Cl)CC1(C)C)C3=CC=C(C#N)C=C3 CC=1N=CSC=1CCC(=O)NCC2=NC=CC=C2CNC(=O)[C@H1]3C[C@@]34CCOC4 COC1=CC=CC(C(=O)N[C@H1](CC=2C=C[NH1]N=2)C(=O)N(C)[C@@H1](C)C(=O)OC)=C1 CSC=1C=NN(C)C=1C(=O)NCC[C@H1]2[C@@H1](C)CCCN2C(=O)C3=CN=C(O)O3 CC(C)(C)OC(=O)N1CC2(CCC2)[C@H1]1CN3CCC45CC(C4)CC3C5 CN1C[C@H1]2[C@@H1](C1)[C@@H1]2C(=O)NC[C@@H1](O)C(=O)N3[C@H1](CO)CCC34CCC4 O=C(N[C@H1]1CCN(C(=O)CC=2C=NSC=2)C[C@@H1]1O)C=3SC=NC=3Cl CC=1SC=C(C(=O)NC23COC(CNC(=O)C=CCF)(C2)C3)C=1C C[C@@H1]1CO[C@H1](C(=O)N2CC[C@@](C)(CN=C3[NH1]C(Cl)=NC(C)=C3Cl)C2)C1 CC(C)(O)C(C)(C)C(=O)N[C@@H1]1CCC[C@H1](CNC(=O)C2=CC3=C(S2)CCC3)C1 CO[C@]1(C(=O)N2C[C@H1](C(=O)NOCCC3CC3)C4(CCC4)C2)CC[C@@H1](C)C1 CCCCCC1=CC(C(=O)N[C@@H1](CNC(=O)CCN2C=CC=C2)CC(C)C)=NO1 COCN1C=CC(C(=O)N[C@H1](CO)CNC(=O)C2=CC3=C(C=NN3C)N=C2C)=N1 CC(=O)NC1=CC=C(C(=O)N2C[C@@H1]3C[C@H1]2C[C@H1](NC(=O)C[C@@H1](C)CF)C3)C(Cl)=C1 CCN(CCNC(=O)C1=NC(=O)N(C)[NH1]1)C(=O)[C@H1]2CCOC3(CCC3)C2 CCN1C=C(C(=O)NCCCCN(C)[C@@H1](C)C2=CC=CC=C2Cl)C(C)=N1 CC[C@H1](C)CCCCC(=O)N1CC[C@@](C)(C(=O)NN2C=NN=C2)C1 C[C@H1](CC1=CC=NC=C1)NC(=O)[C@]2(CO)CCN(C(=O)CC3(O)CCCC3)C2 CC1=CC=NC=C1CC(=O)N2CCC([C@@H1]3N(C(=O)C(C)(F)F)CC3(C)CC)CC2 CC/C(C)=C/C(=O)N(CC)[C@H1](C)CNC(=O)CNC(=O)C1=CC=C(C)C=C1 CC1(C)CN(C(=O)[C@@H1](CC2CC2)NC(=O)C#CC3(C)COC3)C[C@H1]1CO C[C@H1](CC(=O)NC[C@H1]1CCN1C(=O)C=2C=C(Cl)N(C)C=2C3=CC=CS3)P(C)(C)=O C=CCC1(C(=O)N(C)CC2=CN=CO2)CN(C(=O)[C@H1]3CCC[C@H1](C)CC3)C1 C[C@H1](CC(=O)NC1(CNC(=O)C2(C3=CC=C(Cl)C=C3F)CC2)CC1)CC(C)(C)C CC=1N=C[NH1]C=1CC(=O)N[C@@H1]2CC[C@H1](N(C)C(=O)C=3N=C(Cl)SC=3C(C)C)C2 CN1N=CC=C(C(=O)N2C[C@H1]3C[C@H1]2CN(C(=O)C=4C=CSN=4)C3)C1=O C[C@H1](CNS(=O)(=O)CC1=CC=C(C(F)(F)F)C=C1)N2C=CC=N2 COC1=CC=C(C)C=C1C=CC(=O)N[C@@]2(C)CCN(CC3=CC(C)=CC=C3F)C2 C=CCN1N=NN=C1[C@H1](N[C@@H1](CCO)C2=CC=CS2)C3=CC=NN3CC CN1C=C([C@H1](NCCCO)C2=NN=NN2CCOCC3CC3)C=CC1=O C[C@@H1](C(=O)NC[C@@H1](C)N(C)C(=O)C1(C2=CC=CS2)CC1)N(C)C CCCS(=O)(=O)N[C@@H1](C)C(=O)N1C[C@H1]2CCN(C(=O)C=3C=CN(C4CC4)N=3)[C@H1]2C1 C=C[C@H1]1CCCCN1C(=O)C[C@H1](NC(=O)CCC=2C=NOC=2)C(F)(F)F CCCC[C@](C)(F)C(=O)N1C[C@@H1](NC(=O)C2=CC=C(Cl)S2)[C@H1](S(C)(=O)=O)C1 COCCC(=O)N1CCC[C@]12CCCN(C(=O)[C@@H1]3CCCC4=NC=CC=C43)C2 CCC[C@H1](O)C(=O)N1CCC(CN(CC)C(=O)C=2C=C(C)N(C3CC3)N=2)CC1 CO[C@@H1](C(=O)N[C@H1]1CC[C@H1](C)N(CC2=CC=CC=C2F)C1)[C@H1]3CCOC3 CNC1=CN=C(Cl)C=C1C(=O)N2CCN(C(=O)[C@H1](C)CO)C[C@](C)(F)C2 C[C@@H1](NC1(CO)CC1)C(=O)NC2=NC3=C(S2)CC4(CC3)OCCO4 CN(C(=O)C1=NO[C@H1]2COC[C@@H1]12)[C@@H1]3CCCN(C(=O)C[C@@H1]4CC[C@@H1](C#N)C4)CC3 CO[C@@H1](C(=O)NC[C@@]1(F)COCCN(C(=O)CC=2C(C)=NOC=2Cl)C1)C3CC3 CN1C(=O)OC[C@@H1]1C(=O)N[C@H1]2CN(C(=O)CN3C=NC([N+1](=O)[O-1])=C3)C(C)(C)C2 COC1=CC([C@@H1](C)NC2=NC=C(C)C=C2S(=O)(=O)NC[C@H1](C)S(C)(=O)=O)=CC=N1 CCC1=CC=C(C(=O)N2CCC[C@H1]2CN(C(=O)[C@@H1]3CC4CC3C4)C5CC5)C(C)=N1 COC(=O)C[C@@H1](C)OC(=O)CC1=CSC(C2=NC=CC=N2)=N1 N#CCCCCC(=O)NC[C@@]1(CO)CCN(C(=O)[C@H1](F)C2(O)CCCC2)C1 CC(C)(C)C(=O)N1C[C@@H1](O)C[C@@H1](NC(=O)C2=CC=C(CS(N)(=O)=O)C=C2)C1 CCC(CC)(CCC(=O)NC1(CCO)CN(C(=O)C[C@H1](C)P(C)(C)=O)C1)[N+1](=O)[O-1] COC1=NC(Cl)=C(C(=O)N2CCCC[C@H1]2CNC(=O)[C@H1]3CC(F)(F)C3(C)C)S1 CC1=NOC(C)=C1[C@@H1](C)C(=O)NCCCNC(=O)[C@H1](C)CC(N)=O CCC1=NOC2=NC=C(C(=O)NC[C@@H1](NC3=NC=CN=C3C#N)C4CCC4)C=C12 CC1=CC(Br)=CC=C1[C@@H1](CO)NC2=NC(Cl)=NC3=C2N=CN3C COC1=NC=C(C(=O)NC[C@]2(F)C[C@H1](NC(=O)C[C@H1](C)F)C2)S1 CC(C)C=1N=NSC=1C(=O)NC[C@@H1]2CCN(C(=O)C3=C4CCCN=C4NN3)C2 COC[C@]1(C)CN(C(=O)CC2=CC=CC(OC3=CC=CC=C3)=C2)C(C)(C)CO1 C=C[C@@H1]1CCN(C(=O)CC2(NC(=O)C=CC3=CC=CO3)CCC2)C1 O=C(O)C1=CC=C(O)C(C(=O)N[C@H1]2CCCN3C=CN=C32)=C1 C[C@H1](CCN=C1C=C[NH1]C=C1S(=O)(=O)N2CC[C@H1](O)[C@@H1]2C3=CC=CC=C3)C(F)F CN(CCNC(=O)[C@H1]1CC[C@](C)(O)C1)C(=O)C[C@H1]2CC2(C)C CCCC[C@@H1](CC)CCC(=O)N1CC(C2CCN(C(=O)C3=CC(Cl)=C[NH1]3)CC2)C1 C=CC[C@@H1](NC(=O)NCC1=NN=C(C2CCC2)S1)C3=CC=NC=C3 O=C(NC[C@@]1(O)CCN(C(=O)C2=CC3=C[NH1]C=NC3=N2)C1)C4=CC=5OC=CC=5S4 CO[C@@H1](C)C(=O)N1CCN(C(=O)C=2SC=NC=2C)C[C@@]3(C)CCC[C@H1]13 O=C(CSC1=NN=CS1)N2CCN(C(=O)CC3=CC=CS3)[C@@H1]4CCCC[C@@H1]42 COC1(OC)CC[C@H1](CN(C)C(=O)[C@H1](C)C2=CC=CN=C2)C1 COC1=CC=C(C(=O)NCCC(C)(C)NC(=O)CC2=CN=C(C)S2)C=C1Cl CC1=CC=C(C(=O)NCC#CCNC(=O)C2=CC=CC(OCC(F)F)=C2)C(F)=C1 CC(C)(C)OC1=CC(C(=O)N[C@]2(C)CCN(C(=O)C=3SC=CC=3CO)C2)=CC=N1 C=C(C)[C@@H1]1OCCC[C@H1]1C(=O)N[C@@H1]2CO[C@]3(CCN(C(=O)C4=COC(C)=C4)C3)C2 CCCCC1(C(=O)N2CCN(C(=O)C=3C=C(C)N(C)C=3)[C@H1](C(C)C)C2)CC1 CCC[C@@H1](NC(=O)CSCC1=CN2C=C(C)C=C(C)C2=N1)C3CCCCC3 CCN1CC[C@H1]1C(=O)N[C@H1]2CCC[C@H1]2NC(=O)C3=CC(C)=CC(C(=O)OC)=C3 COC1=CC=C(Cl)C(C(=O)N2CC[C@@H1](NC(=O)[C@H1](C)CSC)C23CCCC3)=C1 CCCOC1=CC=C(OCCN2CCO[C@@H1]([C@H1]3CC3(F)F)C2)C=C1 CC(C)OCCCC(=O)N[C@H1](C(=O)NCCC1=NC=CC=C1F)[C@@H1](C)O C=CC[C@H1](CC)C(=O)NCC=1OC=NC=1C(=O)N(CC)CC(=O)NC2CC2 CC1=CC(C(=O)N2CCC[C@H1]2CNC(=O)[C@H1](C)CC(C)(F)F)=CC3=C1CCC3 CC(C)[C@@H1](CCN(C)C(=O)C1CC(CF)C1)NC(=O)C2=CNC3=NCCC3=C2 COC[C@@](C)(O)C(=O)N1CCC(=CCNC(=O)C2=CC=CC=3N=COC2=3)CC1 C=CCCC1(C(=O)NC2CCC3(CC2)C[C@H1]3NC(=O)C4=CC=C(Cl)C=C4C)CC1 CCC1=NC(C(=O)N[C@@H1]2CCC[C@H1](NC(=O)C=3C=CSC=3)CC2)=C(C)O1 C[C@H1](C(=O)NC12CCC(CC1)N(C(=O)[C@H1]3CCS(=O)(=O)N3)C2)N4CCC4 CC(C)(C(=O)N[C@H1]1C[C@@H1](CNC(=O)C2=CC=3SC=NC=3[NH1]2)C1)N4C=NC=N4 CCS(=O)(=O)C1=CC=CC=C1CCNC(=O)C2(C3=CC=NC(Cl)=C3)CC2 CCCC=C[C@@H1](O)C(=O)N1CCCC[C@H1]1CCNC(=O)C2=CC=CC(CF)=C2 CCOC(=O)CC(=O)N1CCC[C@H1]1C(C)(C)CNC(=O)[C@@H1](CO)C(F)(F)F CC1=NC=C(C(=O)N[C@H1]2C[C@H1](CNC(=O)C3=CN(C4CC4)C=N3)C25CCC5)O1 C#CC1(C(=O)NC[C@H1](O)C2=CC=CS2)CN(C(=O)C3=CC=C(CC#N)C=C3)C1 C[C@H1]1C(=O)C[C@H1]1C(=O)N(C)CCN(C)C(=O)C(C)(C)C C=CC[C@@]1(NC(=O)[C@@H1]2CC(=O)N2)CCCN(C3=NN=C(CC)C(CC)=N3)C1 CCN1C=C(C(=O)N2C[C@@H1]3CC[C@]3(CNC(=O)CNC(C)=O)C2)C(C)=N1 CCCCC(=O)N1CCC[C@H1]1C2(NC(=O)C3=CC(OC)=NN3C)CC2 CCN(CC)C(=O)[C@@H1](C)NC(=O)CCNC(=O)C=1OC=CC=1C C[C@H1](CNC(=O)C=1C=C2N(N=1)CCCC2)C3=CC=CC(Cl)=N3 CC[C@]1(C(=O)N2CCC(C)(C)[C@H1]2C)CCCN1C(=O)C3=NC=NC(C)=C3C CN(C[C@@H1]1CCN(C(=O)C2COC2)C1)C(=O)[C@H1]3CCOC(C)(C)C3 C[C@@H1]1CN(C(=O)CC2(N3CCCC3)COC2)C[C@H1]1NC(=O)[C@H1]4CC5(CCC5)CO4 CC1=NSC=C1CN(C)C2=NC(N3CC[C@]4(CCCN4C)C3)=NC=5C=CSC2=5 C[C@H1](O)[C@@H1](O)CNC(=O)[C@H1]1CCCN(C(=O)C2CC(F)C2)CC1 C[C@H1](CN(C)C(=O)CC1=C[NH1]C=CC1=O)NC(=O)CSC2=CC=CC(F)=C2 CC[C@@H1](CNC(=O)[C@@H1](CC)N(CC)CC)NC(=O)C1=CC=C(O)C(F)=C1 CC(C)(C)[C@H1](O)C(=O)NCC1=NC(O)=CC(CNC(=O)C(C2CC2)C3CC3)=N1 CCS[C@H1](C)C(=O)NCC12CC(NC(=O)[C@H1]3CC(C)(C)CCO3)(CO1)C2 C=C1CC2(C1)CC(C(=O)N3CCO[C@H1](CNC(=O)CCOCCN(C)C)C3)C2 CCCC1(C(=O)N[C@@H1]2[C@@H1]C3CCN(C(=O)C4=COC=N4)[C@H1]3C2(C)C)CCC1 CC1=CC=C([C@@H1](C)C(=O)NCCCOC2=CC=CC(C)=C2C)C=C1 COCCCC(C)(C)C(=O)NC1CCN(CCNC(=O)CC2CC(F)(F)C2)CC1 CC[C@@H1](C)CCCCC(=O)N(C)CC(C)(C)C(=O)N1CC(OC(=N)O)C1 C=C(C)CCC(=O)N[C@@H1]1C[C@H1](C)N(C(=O)C=2N=COC=2C3CCC3)C1 CC[C@@H1](CCCC(=O)NCC(=O)NC1CC1)NC(=O)CN2CCNC2=O C[C@@H1]1COCC[C@H1]1N(C)C(=O)C2(NC(=O)C3=NC=C4C=CC=CN34)CC2 COC1(CN=C(NCC(F)(F)Cl)N2CCC(OCC3CC3)CC2)CCCC1 CC1CCC2(CC1)CC[C@@H1](CNCC3=CC=CC=C3N4C=CC=N4)O2 CC[C@H1](CNC(=O)[C@H1](CO)NC(=O)[C@H1](F)N1C=CN=C1)N(C)C [N-1]=[N+1]=N[C@@H1]1CN[C@H1](C(=O)NC[C@H1]2C[C@@H1]2C3=CC=CC=C3)C1 CN(CCCCN(C)C(=O)[C@@](C)(CF)C1=CC=CC=C1)C(=O)C=C2CCC2 C[C@H1](NC(=O)C1=NC=CC=C1F)[C@]2(O)CCN(C(=O)[C@H1]3CCN4CC[C@H1]3C4)C2 CCCC1=CC=C(C(=O)N[C@@H1]2CCC[C@@H1](CNC(=O)C(C)(C)F)C2)C=C1N C#C[C@@H1]1N(C(=O)C2=CC(C)=CC(OC)=C2)CC13CCOCC3 C=CCCCCNC(=O)C1=CC[C@@H1](NC(=O)[C@@H1](CO)C(C)(C)C)C1 O=C(NCC1(NC(=O)C2=CC(F)=CS2)CCCC1)C3=C(Cl)CCC3 CCC1=NOC(CC)=C1CC(=O)N2CCCO[C@H1](CNC(=O)C(C)(C)F)C2 CCC=1[NH1]C=CC=1C(=O)N2CC[C@H1](N(C)C(=O)[C@@H1](C)CC3=CC=CC(F)=C3)C2 CC[C@@H1](CNC(=O)COCC(F)F)NC(=O)CCC(=O)NCCC1=CC=CC=C1 CC1=NN=CC=C1C(=O)N(C)C[C@@H1](C)CNC(=O)[C@H1]2CCCCN2C CC1CCC(CO)(NS(=O)(=O)[C@@H1]2CC[C@@H1]3[C@@H1](C2)C3(F)F)CC1 CC[C@H1](C)N1N=CC(C(=O)NC2=CC=CC(C3=CC=CC=C3)=C2)=C1C CCOC(=O)[C@@H1](CC)C(=O)N1CC[C@@H1](NC(=O)C2CN(S(=O)(=O)CC)C2)C13CC3 O=C(NCCSCC(=O)N1CCC2C1(CO)CCC2)C3=CC(O)=CS3 CSC1=CC=C(CCCC(=O)NC[C@H1](O)CN(C)C(=O)C2CC(F)C2)C=C1 C[C@@H1]1C[C@](C)(C(=O)NCC2(F)CCN(C(=O)C=3SN=NC=3C4CC4)CC2)CCO1 CCOC(=O)NCC(=O)N[C@@H1](CCC(C)(C)C)C1=CC=CC=C1 C[C@H1]1CN(C(=O)C(C)(C)C#N)CC[C@@H1]1NC(=O)C2=C(F)C=CC=C2F C[C@H1](CNC(=O)CCN1C=C(C2=CC=C(C#N)C=C2)N=N1)CC3=CC=CS3 COCC1=CC=C(F)C=C1C2=CC=C(C(=O)N3CCC[C@]4(CCO4)C3)C(C)=C2F CCC(F)(F)C(=O)NC[C@]1(O)CCN(C(=O)[C@H1](C)NC(=O)OC(C)(C)C)C1 COCC=1C=C(C(=O)N[C@H1]2C[C@@H1]2CNC(=O)C3=CN=CO3)ON=1 CC1=CSC(CC(=O)NC[C@H1](NC(=O)C2=CC3=C(C=CN3C)S2)[C@@H1](C)C(C)C)=C1 CCCC1(C(=O)N[C@H1](CNC(=O)[C@@]2(C)CC2(Cl)Cl)C3=CC=C(F)C=C3)CC1 CC[C@H1](SC)C(=O)NC[C@]1(C)CN(C(=O)C=2C=CSC=2C)C[C@H1]1C CSCC(C)(C)C(=O)NC[C@@H1]1CCCCCN1C(=O)C2=NC=NC=C2Cl C=C1CC(C(=O)N[C@H1]2CCN(C(=O)CCN(C)CCC)CC2(C)C)C1 C[C@@H1]1C[C@@H1](C(=O)NCC2(C3(NC(=O)C=C4CCC4)CC3)CC2)CCS1 CCC1=N[NH1]C(=N[C@H1](C)[C@@H1]2CCN(C(=O)C3=CN4C(=N3)C[C@H1](C)CC4)C2)S1 O=C(C1=CSC=N1)N2C[C@H1]3C[C@@H1](C2)[C@@H1](NC(=O)C4(C(=O)NC5CC5)CC4)C3 CCC[C@@H1](NC(N)=O)C(=O)N[C@H1](C(=O)NC1CSC1)C2(C)CC2 CC(=O)C(=O)N1CC(C2C[C@H1](CNC(=O)CCCCCC(C)C)OC2)C1 CC=1[NH1]C2=CC=C(C(=O)N[C@H1](C(=O)NC3=CC(Cl)=NC=C3I)C(C)C)C=C2C=1C CCC=1OC(C)=CC=1C(=O)N[C@H1]2C[C@@H1](N(C)C(=O)C=3C=COC=3C)C2 CC1(C(=O)NC[C@@H1]2CN(C(=O)C3=CC=CC(F)=C3)CCO2)C[C@H1]4C[C@@H1]4C1 CC1=CC(C)=C(C(=O)NC[C@@H1](C)NC(=O)[C@H1](C)OC2=CC=CC=C2C#N)C=N1 CC1=NC=C(CO)C(CNC(=O)NCC2=NC3=CC=C(F)C(F)=C3[NH1]2)=C1O CC#CCCC(=O)N1CCC[C@@H1]2CN(C(=O)CC3=NC=C(C)S3)CCC[C@@H1]21 O=C(CC=1C=CON=1)N[C@@H1]2C=CCN(C(=O)C=3C=NN4C=CN=CC=34)C2 CC(=O)C1=CC=C(C(=O)N2C[C@@H1]3CCN(C(=O)CC=4C=C(C)ON=4)[C@@H1]3C2)[NH1]1 CNC(=O)N1CC[C@@H1](C(=O)NCCCNC(=O)[C@@H1](C)NC(N)=O)C1 CCC[C@H1](OC)C(=O)NC[C@H1](C)N(C)C(=O)COC1=CC=C(O)C=C1 COCC1(COC)C[C@@H1]1C(=O)NC[C@]2(O)CCN(C(=O)C3=CC=NN3C(C)C)C2 CC1(C)[C@H1](NC(=O)C23C[C@@H1]4CC2(CO)C[C@@H1]4C3)CCN1C(=O)C=CC=C(Cl)Cl C[C@@H1]1CN(C(=O)C(F)=CC2CC2)C[C@H1]1CCNC(=O)C3=NC=C4C=C(Cl)C=CN34 CCOC(=O)[C@@H1](F)C(=O)N[C@@H1](C)CCNC(=O)[C@H1](OC)C1CCCC1 COC(=O)C1=NN(C)C=C1C(=O)N2CCC([C@H1](C)CNC(=O)C(C)(Cl)Cl)CC2 COCCN(CCO)C(=O)[C@@H1]1C[C@H1](C)CN(C(=O)C2=CN=C(C)N=C2C)C1 CC(=O)N1C[C@@H1](O)C[C@@H1]1C(=O)N[C@@H1]2C[C@H1]2CNC(=O)C3(C)CCCCCCC3 CC1=CN=CC(CN2CCC(F)(F)[C@@H1](NC(=O)[C@H1](NC(C)C)C(C)C)C2)=C1 CC(C)=CCC(=O)NC1(CN(C)C(=O)C2=CC3=CC=CN3C(O)=N2)CC1 CC1=CC(C)=C(C(=O)N2C[C@H1](NC(=O)CCOC(C)C)C3(CCC3)C2)C(C)=C1 O=C(NC[C@]1(C2CCOCC2)CCN(C(=O)C3=CSC(Cl)=C3)C1)[C@@H1](F)C(F)(F)F CC1=CC(CCC(=O)N2CCCN(C(=O)CN3C[C@H1]4C[C@H1]4C3)[C@H1](C)C2=N)O1 C[C@@H1](C(=O)N(C)CCCCC(=O)NC[C@@H1]1C[C@H1]2CC[C@@H1]1O2)N3C=CC=C3 C=C[C@H1](C)CCNC(=O)[C@@H1]1C[C@H1](C)CN(C(=O)COCC(C)(C)C)C1 CC(C)[C@H1](CNC(=O)[C@H1]1CC[C@@H1](C)C1)NC(=O)CCNC(=O)C2CCCCC2 CCNC(=O)C(=O)N1CC[C@H1](N(CCO)C(=O)CCCOC2=CC=CC=C2F)C1 C#CCC(CC#C)C(=O)N1CCC(N(CC(C)C)C(=O)CCF)CC1 C[C@H1]1C(=O)NCCN1C(=O)[C@H1]2C[C@H1]3CC[C@@H1]2N3C(=O)[C@H1]4CC[C@H1](C5CC5)C4 CO[C@@H1](CCNC(=O)C=1C=NSC=1C)C(=O)N2CCS(=O)(=O)CC2 CCOC(C)(C)CNC(=NCCC(C)C)NCC1CCN(C2=CC=CC=C2)CC1 C=C[C@H1]1CN(C(=O)[C@@H1](CSC)OC)C[C@H1]1NC(=O)CN2C=NC(Br)=N2 C[C@@H1](CNC(=O)C=CC(=O)C=1C=NN(C)C=1)N=C2N=C(C=3C=NN(C)C=3)[NH1]S2 CCCCSCC(=O)N1CC2(C[C@H1](NC(=O)C[C@H1](C)CN(C)C)CO2)C1 CC(C)CC1=CC=C(C(=O)N2CC[C@@H1]3CN(C(=O)CCC(N)=O)C[C@@H1]3C2)C=C1F O=C(NCC(F)F)C(=O)N1CCC[C@@H1]([C@H1]2CCCCN2C(=O)CCCCCF)C1 CCNC(=O)CCC(=O)NC[C@@H1](CCNC(=O)CN1C=CC([N+1](=O)[O-1])=N1)OC COCCCCC[C@@H1](N[C@@H1](C)CC1=CC=CC(Cl)=C1)C2=NN=NN2C3CC3 CCCC[C@H1](CC)C(=O)N1CC[C@H1](C(=O)NCCC2=NC=CS2)C[C@@H1]1C C[C@@H1]1[C@H1](C(=O)NCC2=CN(C)C=N2)CCCN1C(=O)CCC3CCCCC3 C[C@@H1]1C[C@H1](CNC(=O)[C@@H1]2CCC(=O)N(C)C2)CN1C(=O)CC3=CSC=N3 CC[C@@H1]1[C@@H1](C)CCN1C(=O)N(C)C2=NC3=CC=CC=C3O2 CC1=CC=C(C(=O)N[C@@H1](CC(=O)N2CCC=C(Cl)C2)C(F)(F)F)C=C1O O=C(CC1=CC2=CC=CC=C2C1)N[C@H1]3CCOC34CCCC4 CC1=CC=C(O)C(CNC(=O)C[C@H1]2C[C@H1](C3=CC=CC=C3)NC2=O)=N1 O=C1CC[C@@H1](CC(=O)N[C@@H1](CC=2C=N[NH1]C=2)C(=O)N3CC4(CCOC4=O)C3)N1 O=C(NC[C@@H1]1C2=CC=CC=C2CCN1C(=O)C3=CC=C(Br)O3)[C@H1]4C=CCC4 CC1=CC=C(C[C@@H1](C)C(=O)NC2(C)CN(C(=O)CC34COC(CF)(C3)C4)C2)C=C1 O=C(NC1=CN=CC(CO)=C1)[C@@H1]2CN(C(=O)[C@@H1]3CC(=O)NC(=O)N3)CCS2 C[C@H1](SC(F)(F)F)C(=O)N1CCC2(CCOCC2)[C@H1](NC(=O)C3=CSN=C3Cl)C1 C=CCC1([C@@H1](NC2=CC=C(C3CCC3)C=C2)C4=NN=NN4C)CCOCC1 C[C@@H1]1C[C@H1](CC(=O)NCC[C@H1]2CCCN2C(=O)CC3=CC=CC=N3)[C@@H1](C)O1 CCCO[C@@H1]1CCCC[C@@H1]1C(=O)N(C)CCNC(=O)C2=NC=NC=C2Cl C[C@H1]1CN(C(=O)CSC(F)F)CC[C@@H1]1CNC(=O)C2=CC=C(O)C(F)=C2 C#CC=1C=NN(CC(=O)N2C[C@H1]3CC[C@H1]2CN3C(=O)CS(=O)(=O)C(C)C)C=1 CN1N=CC2=CC(C(=O)NCC34COC(C3)C4)=CN=C21 C[C@@H1]1[C@H1](NC(=O)C2=NN(C)C=C2C(F)(F)F)CCCN1C(=O)CCC=3C=CON=3 C=C=CN1C=CC(C(=O)NC2CN(C(=O)NC3=CC=CC=C3C(C)C)C2)=N1 CCN(C(=O)C1=CC=CC=2[NH1]N=C(O)C1=2)[C@H1]3CCN(C(=O)CSC)C3 CC=1C=C(C(=O)N[C@@H1]2CC(=O)N(C(C)C)C2)SC=1Br CCN1N=NN=C1[C@H1](NCC2=CC(C(C)(C)C)=NO2)[C@H1]3C[C@@H1]4C[C@@H1]4C3 COCC1=NC(C)=C(C2=NC([C@H1]3CC4=CC=CC=C43)=NN2C5=CC=CC=C5F)S1 CC1(C)CC(C)CN1C(=O)CN2C=C(C3=CC(Cl)=CC=C3Cl)N=N2 CC[C@H1](O)C(=O)N1CC[C@H1](C(=O)N2CCC3(CC2)CC(=O)N(C)C3)[C@@H1](O)C1 CCCCCC(=O)N[C@H1]1CCCC12CN(C(=O)C3=CN=CC=C3Cl)C2 CC[C@@H1]1CN(C(=O)CCC2=CC=C(C)C(Cl)=C2)C[C@@H1]1NC(=O)CN(CC)C3CC3 CN(CCNC(=O)[C@]1(C)COC2=CC=CC=C2O1)C(=O)C3=NSC=C3Br CC(C)(C)C1=CC=C(C(=O)N[C@H1]2C[C@@H1](O)CN(C(=O)CC34CC(C3)C4)C2)C=C1 CC(C)C1=CC=C(CC(=O)N2CC(N(C)C(=O)C3=CC(C4CC4)=NO3)C2)C=C1 O=C(/C=C/C(F)(F)F)N[C@H1]1C[C@@H1](CNC(=O)C=2C=CC3=NN=C(O)N3C=2)C1 CC(C)[C@H1]1[C@H1](C(=O)NCCC2=CC=C(O)C=C2)CCN1C(=O)C=3C=C(F)N(C)N=3 CCS(=O)(=O)NCC1=CN([C@@H1](C)C(=O)NC2([C@H1](O)COC)CC2)N=N1 C[C@@H1](CC(=O)NC1=CC=CC(NC(=O)C2CC(CC3CC3)C2)=C1)C4CC4 COC1=NC=CC(Br)=C1C(=O)N(C)C2CCN(C(=O)[C@H1]3C[C@@H1](C)CO3)CC2 COC=1SC=CC=1C(=O)N2CCC[C@](F)(CNC(=O)C=3N=C(C)SC=3C)C2 CC(=O)N[C@@](C)(C(=O)N(C)CCNC(=O)C1=CC=C(C#N)C=N1)C2CC2 CC1=NO[C@](C)(C(=O)N2CCC(O)(CNC(=O)C3=NC(C4CC4)=CS3)CC2)C1 CC1=CC(Cl)=CC(C(=O)N2CC[C@@H1](C)[C@H1]2CNC(=O)CC3=COC(C)=N3)=C1O C[C@H1](C(=O)N1CCC=C(C(=O)NCCCN2CCOCC2)C1)C=3C=C[NH1]N=3 CCCCC/C=C/C(=O)N1[C@H1](C(=O)NC2=CC=C(C)C(O)=C2)C[C@H1]3C[C@H1]31 O=C(NC1=CSC(C2=CC=CC=N2)=N1)[C@@H1]3CC(C4=CC(F)=CC(F)=C4)=NO3 C[C@H1]1[C@@H1](NC(=O)C=2ON=C3C=CC=CC=23)CCN1C(=O)[C@@H1](O)CCN4C=NC=N4 CCCC(C)(CCC)C(=O)N1CC2(NC(=O)C[C@H1](O)CCC)CCC1CC2 COC(=O)C1=NOC(C)CC=C1NC(=O)NC(C)(C)CC(=O)N2CCCC[C@@H1]2C CCC[C@]1(NC(=O)C=2N=NN(C)C=2C)CCCN(C(=O)CSCC(=O)OC)C1 CC1(C)CCO[C@@H1]1CC(=O)NC[C@@]2(F)CC[C@@H1](NC(=O)CC3=CC=C(Cl)C=C3)C2 CO[C@@H1](C(=O)N[C@@H1]1CN(C(=O)C2=CC=NC=C2N)CC13CCC3)C4CCCCC4 CC1=CC(C(=O)N2C[C@@H1]3CCN(C(=O)C[C@@H1]4CCCCC45CC5)C[C@@H1]32)=CN=C1O C#C[C@@H1](CC)NC(=O)C1=CC=C(CNC(=O)CN2[NH1]C=NC2=N)S1 CC1=CC(C(=O)N2CCN(C(=O)C3=CC(N)=C(Cl)C=N3)C[C@H1]2C)=CC=C1Cl C#CCC1(C(=O)NCCCC[C@H1](C)NC(=O)C2=CSC(COC)=C2)CCCC1 CC[C@H1](C(=O)NCCC(=O)N(C)[C@@H1]1CCCN(C)C1)C(F)(F)F CSC[C@H1](C)C(=O)N[C@H1]1C[C@H1](NC(=O)[C@@]2(C3=CC=C(F)C=C3)CC2(C)C)C1 CCC(=O)NC1=CC=CC=C1C(=O)N[C@@H1]2C[C@@H1]2NC(=O)CSCC(C)C C[C@@H1]1CCCCN1C(=O)[C@@]2(F)CCN(C(=O)C=3C=COC=3)C2 C[C@H1](C(=O)N[C@H1]1CC[C@@H1](C2CC2)C1)N(C(=O)[C@@H1](C)C(F)(F)F)C3CC3 C[C@@H1](NC1CC2=C(C=CN=C2Cl)CC1)C(C)(C)C3=CC=CC(OC(F)(F)F)=C3 CN(C(=O)C1(C2CC2)CN(C(=O)C[C@@H1]3CCC(=O)N3)C1)[C@H1]4CCOC4 CCN1C=CC(C(=O)N2CC[C@H1]3CN(C(=O)CC4(COC)CC4)C[C@H1]32)=N1 CCN1C=CC(C(=O)NC2=CC=C(C3=CC=C(CN4C=NC=N4)C=C3)C=N2)=N1 CC1=CC=C(C(=O)N[C@@H1](CC=2C=N[NH1]C=2)C(=O)N3C[C@H1](C)[C@@H1](CO)C3)C=C1F CC1=CC(Cl)=C(C(=O)N(C)C[C@H1]2CCN(C(=O)[C@@H1]3CCOCC3(C)C)C2)C=C1F CCC1=CC(C(=O)N[C@@H1]2CN(CCC=3SC=NC=3C)CC(F)(F)C2)=NO1 C=CCCC(=O)N1C[C@H1](N=[N+1]=[N-1])[C@H1](NC(=O)C2=CC=C(N3C=CN=C3)N=C2)C1 CC1=CC=C(Br)C(C(=O)N2CCC[C@@H1](CCNC(=O)CCCC(C)C)CC2)=N1 C[C@H1](CNC(=O)CC(F)(F)Cl)N(C)C(=O)CC1=CC=C(Br)C(O)=C1 CC1(C)CN(C(=O)C2=CC=C(Br)C(F)=C2N)[C@@H1](CO)CO1 CCCC=CC(=O)N1CC=C[C@H1](NC(=O)C2=CN(C)C3=CC=C(C(C)C)C=C23)C1 C[C@H1](CO)C(=O)N[C@H1]1CN(C(=O)C2=CC=C3C(=C2)OCCN3)C[C@H1]1C C[C@H1]1OCC[C@@H1]1CN(C)C(=O)C=2N=COC=2CNC(=O)C3=COC(C(N)=O)=C3 CN(CC1=C(F)C(F)=C(F)C(F)=C1F)C2CCC3(CCOCC3)OC2 C[C@]1(O)C[C@@H1](C(=O)N2CC[C@@H1](CNC(=O)C[C@@H1]3C[C@H1]4CC[C@H1]3O4)C25CCC5)C1 CCCCO[C@H1]1C[C@H1](NC(=O)CNC(=O)C2=CC=CO2)C1(C)C C[C@@H1](C(=O)NC[C@@H1](C(=O)N1CC(C)(F)C1)C(C)(C)C)N(C)C C=C=C(C)CC(=O)N1C[C@@H1](COC)C[C@H1]1CNC(=O)C2=CN=C3N(C2=O)CCS3 C#CC[C@](C)(CC)C(=O)N[C@@H1](CCC)C(=O)N(C)CC1=CC=NC=N1 NC(=O)NC1CC(NC(=O)CCCCCCNC(=O)C=CC2CC2)C1 CO[C@H1](CN(C)CC(=O)[C@@H1]1CCN(C(=O)OC(C)(C)C)C1)C2CC2 COC[C@](C)(O)CC(=O)N[C@H1]1CC[C@H1]1CNC(=O)CCN2C=CN=C2C(C)C CCC(=O)N1CCC[C@H1](C(=O)NCCC2=CC=CC(Cl)=C2)[C@H1]1CC O=C(COC1=CC=C(Cl)C=C1)NC2C[C@@H1]3CCC[C@H1](C2)N3C4CC4 CSC1=CC(=NC(=O)[C@H1]2COCCN2C(=O)[C@H1]3[C@H1](C(C)=O)C3(C)C)[NH1]N1C CCN1C=C(C(=O)N[C@@H1]2CCN(C(=O)C3=NN=C(C)C=C3O)[C@@H1](C)C2)C=N1 O=C(NCC1=CC=CC=C1CN2CCOCC2)[C@H1]3CCC[C@H1]3NCC4=NC=C[NH1]4 CCCCCC1=CC(C(=O)N[C@@H1]2CC(=O)NC3=CC(Br)=CC=C32)=N[NH1]1 CC(=O)C=CC(=O)NCCC1(CNC(=O)C[C@H1](C2=CC=CC=C2)C3CC3)CC1 CC1=NC(N2CCN(C(=O)C3=CC(Cl)=CC=C3I)[C@@H1](C#N)C2)=NC=C1Br C=CCC1(NC(=O)C2=CC=NN2CCF)CN(C3=NC(Cl)=NC=C3C)C1 O=C(N[C@@H1]1C[C@H1]2C[C@@H1]1CN2C(=O)[C@H1]3C[C@@H1]3C4CCC4)OCC5=CC=CC=C5 CCCOCCC(=O)NCC1(CCNC(=O)CNC(N)=O)CC1 CN1CCC[C@]1(C)C(=O)NCCC2(NC(=O)CN3C=CC=C(N)C3=O)CC2 CCCN1C=C(Cl)C(C(=O)N2CCC[C@@H1](NC3=C([N+1](=O)[O-1])C=NN3C)CC2)=N1 CC[C@@H1]1CN([C@H1](CC)C(=O)N2CCCN(CC(=O)OC)CC2)CCO1 CN1CC2(C1)CN(C(=O)[C@@H1]3C[C@@H1]4C[C@@H1]4N3C(=O)C=5[NH1]C=CC=5C6CC6)C2 CN(CCOCCCNC(=O)C1=CCCOC1)C(=O)[C@@H1]2C[C@H1]2F CSC1(C(=O)N[C@H1]2CCC[C@@H1](CNC(=O)C3(O)CCOCC3)C2)CC(=O)C1 C=C1CN([C@@H1]2CCN(S(=O)(=O)C3=CC([N+1](=O)[O-1])=CC=C3CCOC)C2)C1 CC(C)CC1=NC(C(=O)N[C@@H1](C)[C@H1]2CCN(C(=O)[C@@H1](C)C3=CN=CN=C3)C2)=CS1 CC[C@H1](C)C1=NC(C)=CC(=NC[C@@]2(OC)CCCC(C)(C)C2)[NH1]1 CCCN(C)C(=O)C[C@H1]1CN(C(=O)C2=CC=CC(F)=C2C)CC13CC3 O=C1CCCN1C2=CC=C(CN=C3[NH1]C(=NCCCCO)[NH1]C=4C=C[NH1]C3=4)C=C2 CCC=1N=C(C)OC=1C(=O)N(C)[C@@H1]2CCN(C(=O)C3=CC=CC=[N+1]3[O-1])C[C@@H1]2C CNC(=O)NCCC(=O)NCCC(C)(C)C(=O)NC[C@H1]1CCCCS1 CCOCC1CCN(C(=O)[C@@H1](CNC(=O)CN2CC[C@@H1](OC)C2)N(C)C)CC1 O=C(N1CCC[C@H1]([C@H1]2C[C@@H1]2NC(=O)C3(F)CCC(F)(F)CC3)C1)C45CC(F)(C4)C5 CC1=CC(=N)[NH1]C=C1C(=O)N(C)C[C@@H1](C)NC(=O)[C@H1]2CCN(C3CCCCC3)C2 COC1(C(=O)NC[C@H1](F)CNC(=O)C2=CC(F)=CC(F)=C2)CCCCCCC1 CCOCC[C@H1](NC(=O)C1=NC=CC=N1)C(=O)NCCC2=CC=CC=C2O CN1CCN(C(=O)[C@H1]2OCC2(C)C)C[C@@H1]1CNC(=O)C=CC3=CC=C(F)C(F)=C3 C/C=C/C(=O)NC12CC(C(=O)NCC3=CC=C4C=CC=CC4=C3)(C1)C2 CCOC=CC(=O)NCCCN(C(=O)C1=CC=C(OCC2CC2)C=C1)C(C)C CC=1C=C(N(C)C[C@@H1](C)NC(=O)[C@@H1]2C[C@@H1]3C[C@@H1]3C2)N4N=C(C(F)(F)F)N=C4N=1 CC[C@@H1]1CN(C(=O)C2=CC=CC(Cl)=C2[N+1](=O)[O-1])CCN1CC3=CC=C(Cl)C(Br)=C3 COC1=CC(C(F)(F)F)=NC(N(C)CCN(C)C(=O)C2=CN=C3N2CCOC3)=N1 CC(C)(O)[C@@](C)(O)CNC(=O)NCC[C@H1]1CC1(F)F CN(CC[C@@H1](NC(=O)C1=CSC=N1)C(C)(C)C)C(=O)[C@@H1](F)C2=CC=CC=C2F CC1=C[NH1]C=C1C(=O)N2C[C@H1]3C[C@H1]2C[C@@H1]3NC(=O)C4(C5=CC=C(Cl)C=C5)CC4 CN1C=C([C@@H1](NC(=O)C2=CC=C(O)C=N2)C(=O)N[C@H1]3CCC(=O)NC3)C=N1 CCC[C@@H1](OCC)C(=O)N1CC[C@H1]2CN(C(=O)C3=CN=NC=C3OC)C[C@H1]21 CC[C@@H1](CNC(=O)C(F)F)NC1=CC=C(S(=O)(=O)N(C)C)C=C1[N+1](=O)[O-1] CC=1SC(O)=NC=1C(=O)N2CCC[C@H1]2CN(C)C(=O)C3=CC=CC=C3[C@H1]4CC4(F)F CCSCC(=O)N[C@@H1]1CN(C(=O)C2=CC=CC3=C2OC[C@@H1]3C)CC4=CC=NN4C1 CC(C)CN1CCC[C@@H1]1C(=O)N(C)CC(C)(C)CNC(=O)C[C@@H1]2CC[C@@H1](C)CO2 C=C(Cl)CNC(=O)[C@H1]1C[C@@H1](C)N1C(=O)[C@H1](C)N(C)C CC[C@H1](CC(=O)N[C@@H1]1CN(C(=O)C2=CC=CC(N)=C2)C[C@@H1]1C)C3CCC3 CC1=NOC(C)=C1C(=O)N2CC[C@@](C)(CNC(=O)CCOCC(C)C)C2 CC=C(C)C(=O)NCC12CC(NC(=O)[C@@H1]3[C@H1]4CC[C@@]3(C5=CC=NC=C5)C4)(C1)C2 CN(C(=O)C1CC(S(C)(=O)=O)C1)C2CCN(C(=O)C=3C=C(CO)ON=3)CC2 CN1N=C(C2=CC=CS2)C3=CC=C(C(=O)OCC(=O)C4=CC=C(Cl)C(Cl)=C4)C=C31 C[C@@H1](C(=O)NCCOCCCNC(=O)CO)C1=CC=CC=C1Br C=CC[C@H1](C(=O)N[C@@](C)(CSC)C(=O)N[C@H1]1CCN(CCC)C1)C(C)C CC1=C[C@H1](C(=O)NCCOC2CN(C(=O)C3=CC=C(C4CC4)C(C)=C3)C2)SC1 C=CC[C@@H1](CC)C(=O)N[C@@H1]1CN(C(=O)CC2=CN=CC(O)=C2)C3(CCOCC3)C1 CCC(=CC(=O)N[C@H1]1C[C@H1](NC(=O)[C@H1](C)SC[C@H1]2CCCO2)C1)C3=CC=CC=C3 CC1=NC(N)=C(CC(=O)N[C@@H1]2CC[C@@H1]2NC(=O)C(C)(C)CC(C)C)C(O)=N1 CCOC1=NC(N2CCC[C@H1]2CNC(=O)[C@@H1]3C[C@H1]3C4CCCCC4)=NC=C1C C#CC[C@H1](NC(=O)C12CCC(CC1)N(C(=O)C3=CC=C(Cl)O3)C2)C(=O)OCC CC=1C=COC=1C(=O)N2C[C@H1](N(C)C(=O)C3C(C)(C)C3(C)C)C4(CC4)C2 CN1CC[C@H1](CC(=O)N2CCCC(C)(C)[C@@H1]2C(=O)N3C[C@@H1](CO)C4(CCC4)C3)C1 CO[C@@H1]1CN(C(=O)C2=CSC(C(F)F)=N2)C[C@@H1]1NC(=O)CCC3=NC=C[NH1]3 C=C1CC(C)(C(=O)N[C@H1]2CC[C@H1](NC(=O)[C@@H1]3CCC[C@@H1](C#N)C3)CC2)C1 CC(=CC(=O)N[C@@H1]1CCC[C@H1](N(C)C(=O)CN=S(C)(C)=O)C1)C2=CC=CC=C2C CSC[C@@H1](C)C(=O)N1CCCC[C@H1]1CC(=O)NCCOC2=CC=CC=N2 CC=1SC=C(C(=O)N2CCN(C(=O)C3=CN=NN3C)C[C@H1]2CC(F)F)C=1C4CC4 CCOC=1C=C(C(=O)N(C)C[C@@H1](O)CN(C)C(=O)[C@@H1]2CCC23CCC3)ON=1 CCCCSCC(=O)N[C@@H1](CC(=O)N(CC)CCCF)C(F)(F)F CC(C)(C)NC(=O)[C@H1](C1=CC=CC(C=2C=C[NH1]N=2)=C1)N3CC[C@H1](CO)[C@@H1](O)C3 CC1(CCC(=O)N2C[C@@H1]3C[C@H1]2C[S@]3=O)CN(C(=O)C[C@H1]4CCC(=O)N4)C1 CC(C)C1=C[NH1]N=C1C(=O)N[C@@H1]2CN(C(=O)C3=C[NH1]C4=CC=CC(Cl)=C34)[C@H1]5C[C@@H1]25 C[C@H1](F)[C@@H1](C)NC(=O)[C@@H1]1COCCN(C(=O)C2=CC=C(C#N)S2)C1 CC[C@H1](O)[C@@H1](C)C(=O)NCC1(COC)CN(C(=O)[C@@H1](F)N2C=CC=N2)C1 N#CC1=CC=CC(NC(=O)CC2(NC(=O)C[C@@H1]3CCCC(=O)N3)CCC2)=C1F C=CCC(=O)NC[C@@H1]1C[C@H1]2CC[C@@H1]1N2C(=O)CC3=CC=C(Cl)C(Cl)=C3C C[C@H1](CNC(=O)[C@H1]1[C@H1](C)OCCN1C(=O)C[C@@]2(O)CCCOC2)C3=NC=CS3 NS(=O)(=O)C1=CC=C(CNC[C@@H1]2C[C@]23CCC4=CC=CC=C43)C=N1 CC[C@H1](C)[C@@H1](OC)C(=O)N1C[C@@H1]2C[C@H1](C1)C2NC(=O)[C@@H1](C)SC CCC(=O)NC1=CC=CC(C2=CC=C3C=C(C(=O)N4CC[C@](C)(O)C4)SC3=C2)=C1 O=C(NC1=CC=C(Br)C(OCC2CCCCC2)=C1)C(=O)N3C[C@H1]4CC[C@H1]3[C@@H1](O)[C@@H1]4O CC(=O)OC1(C(=O)N2CC[C@H1](N(C)C(=O)C3=CC=C(C)N=C3C)C4(CC4)C2)CC1 CCCOC(=O)C(C)(C)NC(=O)[C@H1]1CN(CC2=CC(C)=NC(C)=C2)CC[C@H1]1O CCOCCC(=O)NC[C@]1(F)CCN(C(=O)[C@H1](CO)NC(=O)C(C)C)C1 CC/C=C/C[C@H1](C)C(=O)N1CC2(NC(=O)[C@@H1](C)C3=CC=C(F)C=C3)CC1C2 COC1=CC=CC=C1[C@H1](NC(=O)CC2=C(O)N=CN=C2O)C3=CC=CO3 COC(=O)[C@@H1]1CC[C@H1](NC(=O)N2CC[C@@]23CCCS(=O)(=O)C3)C1 CCCCC[C@H1](CC)C(=O)N1CCCCCC[C@H1]1C(=O)NC2CN(CCOC)C2 COC(=O)C1=CON=C1C2CN(S(=O)(=O)CCC3CCOCC3)C2 CC1=CSC(Cl)=C1C(=O)N2CC(CO)(NC(=O)C3=CC(Cl)=C[NH1]3)C2 C=C1C[C@@H1]1C(=O)N[C@@H1]2CCN(C(=O)CO[C@H1](C)CC)C[C@H1]2CC CSCC[C@@H1](NC(=O)C1=CC(O)=NC=N1)C(=O)N[C@@H1](C)C2CSC2 C[C@@]1(C(=O)NC[C@@H1]2C=CCN2C(=O)C3=CC(Br)=CN4C=CN=C34)CCCOC1 CC[C@@H1](C)[C@H1](C)C(=O)NCC1CC2(C1)CN(C(=O)CC=3[NH1]C=NC=3C)C2 C[C@@H1]1CCC[C@H1](C2=CN([C@@H1]3CCN(C(=O)C4=C(Cl)C=CC=C4[N+1](=O)[O-1])C3)N=N2)C1 O=C1CCC(C(=O)N2CC(CNC(=O)C=3C=C(C4=CN=CC=N4)[NH1]N=3)C2)=NN1 C#CCN(CC(=O)OC)C(=O)[C@@H1]1CCC(C)(C)N(C(=O)C2CC3(CCC3=O)C2)C1 CCN(CC1=CC=CC=C1C)C(=O)CN2CCC(N3N=C(C)C=C3C)CC2 C[C@H1](NC(=O)CC1=CC=CC=C1)C(=O)N2CC(CN(C)C(=O)C=3C=CON=3)C2 O=C(NC[C@@H1]1C[C@@H1](O)CN1C(=O)C2=CCC2)C=3SC=CC=3NC4=CC=CC=C4 CC1=CSC(CN[C@@H1](C2=NN=NN2C3COC3)C4CC4)=C1 O=C(C[C@@H1]1CSCCO1)N2CC[C@H1]([C@@H1](F)C(=O)N[C@H1](CF)C3=CC=CC=C3)C2 C=CN1N=CC=C1C(=O)NC[C@H1](CO)NC(=O)C2=NOC3=C2CCCCC3 CC1=NC(C(=O)N2CCN(C(=O)C=CBr)[C@H1](CF)C2)=NN1C=3N=C[NH1]N=3 O=C(C1=CC=CC(F)=C1I)N2CCC(C3=NC4=CC=CC=C4[NH1]3)CC2 C[C@@H1](CNC(=O)[C@@H1]1CCN(C(=O)CC2=CC=C(O)C=N2)C1(C)C)OCCO CCOCC1(C(=O)N2[C@H1]CC[C@@H1]2[C@H1](C(=O)NC[C@H1]3CCCC(=O)N3)C)CC1 CC[C@H1](NC(=O)CSC=1C=N[NH1]C=1)C(=O)NCC(=O)N2CCOCC2 CCN(CC(N)=O)C(=O)[C@@H1]1COCCN(C(=O)C[C@@H1](C)COC)C1 C=CCN(OC)C(=O)C1=COC(CNC(=O)[C@]2(C)CCCN2C)=C1 C1C=CC(C)=NC(CN=C2N=C3SC=CC3=C(NCC4CC5(CC5)C4)[NH1]2)=N1 CC(C)(C)OC(=O)NC1=CC=CC(S(=O)(=O)N[C@H1]2CCCC23CC3)=C1 C=C[C@H1](OC)C(=O)NCC1=NC(C(=O)NC[C@]2(C)CCC(=O)N2)=CO1 CCCN(CCCN(C)C)C(=O)/C=C/C(C)(C)NC(=O)COCCOC COC(=O)CC(=O)N(CCCNC(=O)C12CCC(C)(CC1)CC2)C3CC3 C=C[C@@H1](C)CC(=O)NCC(C)(C)CNC(=O)C1=CC=C(OC)C=N1 CCC1(C(=O)N[C@@H1](CO)C2=CC=CN=C2)CN(C(=O)C[C@@H1](O)CC(C)C)C1 CC(=O)NCCC(=O)N1C[C@@H1]2C[C@H1](C1)CN2C(=O)C3=NC(C)=NC=C3Br CC1=C(CN(C)C(=O)C23[C@@H1](NC(=O)CN(C)C(C)C)C4C[C@H1]2[C@H1]3C4)C=NN1C CC[C@H1]1CC[C@H1](C(=O)N(C)CCNC(=O)C2=C(C)OC3=NC=NC(O)=C23)C1 CC[C@@]1(C)CCN1C(=O)[C@H1]2C[C@@H1](NC(=O)C#CC3(C)COC3)C2 CC(C)(C(=O)N1CCN(C(=O)C2=CC=C([N+1](=O)[O-1])O2)CC3(CC3)C1)[C@@H1]4CCOC4 CC1=CN=C([C@H1](C)CN[C@H1](CN(C)C)C2CCCCC2)S1 C#CCOCC(=O)N1CCC2(CCCN(C(=O)[C@]3(CC)CC3(F)F)C2)C1 COC1=C(CN2CCC[C@@H1]2C3=CC=C(Br)C=C3F)C=CC=C1C4=CC=CC=C4 CC1=CC(C2=CC=CC(NS(=O)(=O)C(F)(F)F)=N2)=CS1 CC1=CC=CC(C2(NS(=O)(=O)C3=CC=C(CS(C)(=O)=O)C=C3)CCC2)=C1 CN1C=CC(C(=O)NC[C@@H1]2CN(C(=O)[C@H1]3CC[C@@H1](C(N)=O)O3)CC24CCC4)=N1 C=C(C)C[C@@H1](NC(=O)C[C@@H1]1CCC[C@H1](C)O1)C(=O)N=C2C=C(OC)N(C)[NH1]2 COC(=O)[C@H1]1CC[C@](F)(CNC[C@H1]C[C@H1]NC(=O)OC(C)(C)C)CC1 O=C(C=1C=NSN=1)N2CC3(C2)CN(C(=O)C4=CC5=CC(Cl)=CC=C5O4)CCO3 C=CCOC1=CC=CC=C1C(=O)NC[C@@H1]2C[C@@H1]2NC(=O)C3=CN4C=C(C)SC4=N3 CCC(CC)N(C)C(=O)[C@@H1]1CCN(C(=O)[C@H1](C)N2C=CN=C2)O1 N#C[C@@]1(C(=O)N2C[C@@H1]3CC[C@H1](C2)N3C(=O)C[C@H1]4CCCOC4)C[C@H1]5C=C[C@H1]1C5 C#CCCONC(=O)CN(C(=O)C1=CC(Cl)=CS1)C2CCC2 CCC(C)(C)N1N=NN=C1[C@@]2(NCC[C@@H1]3CC(C)(C)CCO3)CCN(C4CC4)C2 CCN1C[C@H1](C(=O)N[C@@H1](CCSC)C(=O)N(C)[C@@H1]2CCC[C@H1](C)[C@H1]2C)CC1=O C=C(C)COCC(=O)N1CCOC[C@@H1](NC(=O)[C@@]2(COC)CCOC2)C1 CN1CC=C(C(=O)N2CC[C@@H1]3C[C@@]3(C(=O)NC4(C5CC5)CCCC4)CC2)C1 CN(CC1C(C)(C)C1(C)C)C(=O)C[C@H1]2C[C@H1](NC(=O)C3=CCCOCC3)C2(C)C COC[C@]1(CNC(=O)C2=CC=C([N+1](=O)[O-1])[NH1]2)CCN(C(=O)[C@@H1](C)CC(F)F)C1 CCN(CCNC(=O)C1=NN2C(=C1C)CCCC2)C(=O)CC(C)(C)CN(C)C C=CCC1=CC=CC=C1C(=O)N2CCSC[C@@H1]2CCNC(=O)[C@@H1](C)C3CCC3 CSC1=CC=CC(CC(=O)NC2(CO)CN(C(=O)CN3CC[C@H1](C)C3)C2)=C1 C#CC1=CN=C(N2CCC[C@@H1](NC(=O)CCC3CCOCC3)CC2)N=C1 N1C2=CC(Cl)=NC(C(=O)NC3=CC4=CC=NN4C=N3)=C2S1 CCC=CN1C=NC(C(=O)NCCC2CCN(C(=O)C3(C)CC(C)C3)CC2)=C1 CC1=CC=C(F)C=C1C2NCC(F)(C(=O)N=C3N=C[NH1]N4C=CC(Br)=C34)C2 CC(C)CCC(=O)C(=O)N[C@@]12CC[C@@H1](CN(C(=O)C3(CO)CC(F)(F)C3)C1)C2 CC(Cl)=CC(=O)NCCCOC1CCN(C(=O)[C@@H1]2CCCN2CCC(C)C)CC1 C[C@H1]1CCC[C@@H1](C)CN1C(=O)C2C[C@@H1]3CC[C@H1](C2)N3C(=O)C4=CC=CC=C4F CC1=CC(C(=O)N[C@H1]2C[C@H1](CNC(=O)CC3=CCOCC3)C2)=C(F)C=C1Cl O=C1NC2=CC=CC=C2CC13CCN(C4=CC=NC(NCCN5CC[C@H1](O)C5)=N4)C3 COC1=CC=C(C(=O)N[C@]2(C)C[C@@H1](NC(=O)CCCCSC)C2)C=C1C CCC[C@H1](CC(=O)N[C@@H1]1[C@H1]2COC[C@H1]21)NC(=O)CCC3(C)CC3 O=C(N[C@@H1](CO)[C@H1](O)C1=CC=CC=N1)C2=COC3=CC=C(Br)C=C23 CCC[C@H1](OCC)C(=O)NCCNC(=O)[C@]1(C)C[C@@H1](C(=O)OC(C)(C)C)C1 COCCOCC(=O)N[C@H1](C)CC1CN(C(=O)[C@@H1]2CCC3=C(N=NN3C)C2)C1 CC1=CC(C(=O)N[C@H1](C)CCN(C)C(=O)C2=CC=CC3=NC=CN=C23)=NC=C1Cl C#C[C@H1]1C[C@H1]1C(=O)N[C@@H1]2CCCCN(C(=O)C3=CN4C(=N3)SCC4)C2 C=C1CC(CNC(=O)C2=COCCC2)(C(=O)N3CC[C@H1](O)[C@H1](O)C3)C1 CC1=NO[C@](C)(C(=O)N2CCCC[C@H1](CNC(=O)C3(C#N)CC4(CCC4)C3)C2)C1 CC[C@@H1](C)[C@H1](O)C(=O)NC[C@H1]1CC[C@H1](CNC(=O)CNC2=CC=C(Cl)C=C2)CC1 O=C(NC[C@@H1]1CC[C@H1](NC(=O)[C@@H1]2CCC[C@@H1]3C[C@@H1]32)C1)C4=CN=C5SC=CN45 O=C(C1=CC=C2C=CC(O)=CC2=N1)NCCCN3CCOCC3 COC1=NC=CC(C(=O)NC[C@@H1](O)CC(=O)NCC(F)(F)CO)=N1 CN=C1[NH1]N=C(CC(=O)N(C)C[C@H1]2CC[C@H1](CNC(=O)[C@H1]3C[C@@H1](C)CO3)CC2)S1 CC1=CC(C)=C(N)C(C(=O)NCC(C)(C)CNC(=O)CC[C@H1]2CC[C@@H1](C)O2)=C1 CCOC1(CNC2=CC(=N)[NH1]C3=CC=C(Br)C=C23)CCCC1 C[C@](CO)(CNC(=O)C1=CN(C2CC2)C=N1)NC(=O)[C@@H1](O)C3CCCC3 CCC[C@@H1]1CN(C(=O)C=2SC=C3C=2OCCO3)CCN1C(=O)[C@H1](C)COC C[C@@H1](CNC(=O)C(F)(F)C1=CSC(Br)=C1)NC(=O)CCC=2C=CN(C)N=2 COC(CNC(=O)[C@H1](C)CCC1=CC=C(F)C=C1)(OC)C2=CC=CC=C2 C[C@@H1]C1CN(CC(=O)N(CCO)[C@@H1]2CCCN(C(=O)COC3=CC=C(Cl)N=C3)C2)C1 CC(=CC(=O)N1CC[C@@H1]([C@@H1](C)NC(=O)[C@@H1](C)CC2CCCC2)C1)C(C)(C)C CC1(C)COC[C@@H1]1C(=O)N[C@H1]2CC[C@H1]2CNC(=O)C3=CC=NC(Cl)=C3N C[C@@H1](CC(F)F)C(=O)N(C)[C@@H1]1CCCCN(C(=O)CC23COC(C)(C2)C3)C1 CC1=CC=C(O)C=C1C(=O)N2CCC[C@H1]2C(C)(C)NC(=O)C=3C=NN(C4CC4)C=3 CC1=NC(CC(=O)NC[C@]2(O)CCCN(C(=O)CN3C=NC=N3)CC2)=CO1 CC1=C(C(=O)N2CCO[C@@H1](CCNC(=O)C34CC(C#N)(C3)C4)C2)N=NN1C(C)C [N-1]=[N+1]=NCCCOCC(=O)N[C@H1]1CCO[C@H1]1C(=O)NCCOC2CC2 C=CC[C@@](C)(O)C(=O)N1CCC[C@@H1](CN(C)C(=O)CCCCC2CC2)C1 CN1N=CC(C(=O)N[C@H1]2C[C@@H1](CNC(=O)[C@@H1]3CC[C@]34CCCO4)C2)=C1Cl CC(=O)N(C)CC(=O)NCC[C@@H1](O)CNC(=O)C1=CC=C2C=C(C)C=CC2=C1 C[C@@H1](C(=O)N1C[C@H1](NC(=O)CC2(C#N)CC2)CC13CCOCC3)C(C)(C)C COCC[C@H1]1CN(C(=O)CC[C@@H1](C)N(C)C)CCN1C(=O)CC2CC3(CC3)C2 COC1(CC(=O)N2CC[C@H1](C3CC3)[C@@H1]2CNC(=O)C=4C=C(C(C)C)N(C)N=4)CC1 CCCCSCC(=O)N1CCC[C@]12CCN(C(=O)C3=NC(C)=NC=C3Cl)C2 O=C(NCCC1=NC=CC=N1)C(=O)N2CCCOCC23CCCC3 CC1=N[NH1]C(C)=C1S(=O)(=O)N2CC[C@@H1]3CN(CC4=CC=CC(O)=C4)C[C@H1]32 CC[C@H1](CC(F)F)C(=O)NC[C@@H1]1CN(C(=O)C2=COC(C(F)F)=C2)CC(C)(C)O1 CCOC(=O)[C@@]1(C)CCN(C2=CC=C(C(=O)N(C)C3=CC=CC=C3)C=N2)C1 CCC1=CC(C(=O)NCC[C@H1](C)CCNC(=O)C2=C(C)C=CC=C2C)=N[NH1]1 C[C@@H1](CC(N)=O)C(=O)N1CCN(C(=O)C=CC2=CC=C(Cl)C=C2)C[C@H1]1CCO CCCC[C@H1](C(=O)N1CCN(C(=O)/C=C/C=2C=COC=2)C[C@H1]1CO)C(C)C O=C(N=C1C=C[NH1]C=C1Br)[C@H1]2C[C@H1](F)CN(C(=O)C3=N[NH1]C=C3I)C2 C#CC1=CC=CC(C(=O)N2[C@H1]3CC[C@H1]2CN(C(=O)C[C@@H1]4CC[C@H1]5C[C@@H1]5C4)C3)=C1 O=C(CC1=CN=CC(Br)=C1)N[C@H1]2CN(C(=O)CCC3=CC=C(O)C=C3)CC24COC4 C[C@@H1]1C[C@H1]2CN(C(=O)C=3SC=CC=3F)C[C@H1]2N1C(=O)C4=NN=C(O)C=C4O CC[C@H1]1C[C@@H1]1NC(=O)C#CCNC(=O)C2=CSC(O)=N2 COC[C@@H1](C)CC(=O)N1CC[C@H1]2[C@@H1](C1)CN2C(=O)C=3OC(C(F)(F)F)=NC=3C CC1=NC(C(=O)N[C@H1]2COCC[C@H1]2C(=O)N3CC(C4=NC=CC=N4)C3)=CC=C1C CC[C@H1]1CCN(C(=O)C2=NN(C)C=C2Cl)[C@@H1](C(=O)N[C@@H1](C)COCC3CC3)C1 CC[C@](C)(O)CC1=CN(C2(C(=O)NNC3=CC=NC(O)=C3)CCOCC2)N=N1 CCN1C=CC(CC(=O)N2CC(C)(C)[C@H1]2C3CCN(C(=O)C(C)(C)C)CC3)=N1 CC1=CC=C(Br)C(C)=C1C(=O)N[C@@H1]2CC[C@H1]2CNC(=O)[C@H1]3CCC(C)(C)C3 CCN(C(=O)CN=C[NH1]C1=C(C(N)=CC#N)COCC1)[C@H1](C)CS(=O)(=O)CC CC[C@](C)(O)C(=O)N[C@@H1]1CN(C(=O)CC2(N(C)C)CCCC2)C[C@@H1]1C CO[C@H1]1CC[C@@H1](C(=O)N2CCC[C@H1](C(=O)NCC3=CCCC3)C2)CC1 O=C(NC1CCN(C(=O)CO)CC1)C2=NC=CC(Cl)=C2F CC(C)C(C(=O)N1CC(NC(=O)CC2=CC=C(Cl)C=C2Cl)C1)C(C)C NC(=O)C1=CC=C(C(=O)NC[C@]2(F)CCCN(C(=O)C3=NC(Cl)=CS3)C2)O1 CCCC(CCC)C(=O)NC[C@@]1(O)C[C@@H1]2CC[C@H1](C1)N2C(=O)CC3CCC3 CC(C)[C@@H1](CCN(C)C(=O)[C@@H1]1COC(=O)N1)NC(=O)OCC2=CC=CC=C2 CC(C)SCC(=O)N1CC[C@H1]([C@@H1]2CCN(C(=O)C=CC3=CSC=N3)C2)C1 CCOC(=O)CCC(=O)N(C)C[C@H1]1CCN(C(=O)C[C@H1]2C[C@H1](SC)C2)C1 CC=1C=CC2=CC(C(=O)NC[C@H1](CC(F)(F)F)NC(=O)C=3[NH1]C=NC=3C)=CN2C=1 CC1(C)C[C@H1](NC(=O)C2=CC(Cl)=CC(Cl)=C2)CN(C(=O)C[C@H1]3C=CCC3)C1 CC1=CC=C(C(=O)N2CC[C@H1](N(CC3CC3)C(=O)CC(C)(C)C4CC4)C2)C=C1C CNC(=O)NCCC(=O)N1CC2CC1(C(=O)N3CCN4C(C)=NN=C4C3)C2 C[C@H1](CC(=O)N1CC[C@H1](CNC(=O)C23CC(C2)[C@@H1](C)O3)C(F)(F)CC1)C(F)F CC(C)(C(N)=O)C(=O)N1CCC2(CC[C@@H1]2NC(=O)C=3C=CN(C4CC4)N=3)CC1 O=C(NC1(CO)CN(C(=O)C=C(Cl)Cl)C1)C=2SC=CC=2Cl COCCC(=O)NC[C@H1](NC(=O)[C@H1]1C[C@@H1](N2C=NN=C2)C1)C3=CC=C(OC)C=C3 O=C(NC1=NC=C(Cl)C=C1I)C23CCC(C(=O)N[C@@H1]4CCCCC4(F)F)(CC2)C3 CO[C@H1]1C[C@@H1](CC(=O)N[C@H1]2CCN(C(=O)C3=CC=C(S(N)(=O)=O)O3)C[C@H1]2C)C1 C[C@@H1](CNC(=O)C1=C[NH1]C2=NC=CC2=C1)N(C)C(=O)C=3SC4=CC=CN=C4C=3Cl CC1=CC=CC([C@H1](O)C(=O)NC[C@@H1](NC(=O)COCCF)C2=CC=CC=C2)=C1 CC(C)C=1OC=CC=1C(=O)NC[C@H1](NC(=O)C=2C=NN(CCO)C=2N)C3CC3 CC[C@H1](CN(C)C)C(=O)N1C[C@H1](C)[C@H1](NC(=O)[C@H1](C)C=2C(C)=NOC=2C)C1 C[C@H1](CF)CC(=O)N[C@@H1]1CN(C(=O)C2=CC=CC(C3=CSC=N3)=C2)CC14CCC4 CC[C@@H1](C)CCC(=O)N(C)[C@@H1](CC(C)C)C(=O)NCCCOCCCC CC(C)[C@H1](C)CC(=O)N1C[C@H1]2CN(C(=O)CCN3CCCCCC3)C[C@H1]2C1 CCC(CC)[C@@H1](F)C(=O)NCCCN(C(=O)C1=C[NH1]C(C(N)=O)=C1)C2CCCC2 COC(C)(C)CC(=O)NC[C@](C)(F)CNC(=O)CC=1C=C(C)N(C)N=1 CC=1[NH1]N=C(C(=O)NCCC2=C[NH1]C(=NCC=3C(C)=NN(C)C=3C)S2)C=1[N+1](=O)[O-1] CN(C)C1=CN=CC(NC(=O)[C@@H1]2CCC3(CC3)N2C(=O)[C@]4(C)CCCC[C@@H1]4O)=C1 COC(=O)N1CC[C@@H1](CNC(=O)NC[C@H1]2CCC(F)(F)C2)C1 CC1=NC(C2=CC=CO2)=CC(N3CC[C@@H1](C)[C@H1]3CNC(=O)C4=CN=C(C)N4C)=N1 O=C(N[C@@H1]1CN(C(=O)C2=CC=NC=N2)CC3=CC=CC=C31)[C@H1]4CCCC(F)(F)C4 CCN1N=C(C(=O)N2CCC[C@@]23CCN(C(=O)[C@@](C)(O)CC)C3)C=CC1=O C[C@H1](CNC(=O)CC(C)(C)CNC(=O)[C@@H1](C)C=1C=C[NH1]N=1)CC(F)(F)F CCCN(C)C(=O)[C@H1]1CCN(C(=O)[C@H1]2CCC(=O)O2)[C@@H1](CC)C1 COC[C@@]1(NC(=O)C2=CC3=C(C=N2)OCCO3)CCN(C(=O)CCCCC#N)C1 CCN(CC)CCSCC(=O)N[C@@H1]1CC[C@H1]1CNC(=O)[C@@H1]2CCCOC2 C=C(C)C[C@H1](OC)C(=O)N[C@@H1](C)[C@@H1]1CCN(C(=O)C(C)(C)COC)C1 CC1=NO[C@@](C)(C(=O)N[C@H1]2CCC[C@@H1]2NC(=O)C3=CC4=C(S3)CC(C)(C)C4)C1 CC1=CC(Cl)=C(N)C(C(=O)N2C[C@@H1](NC(=O)CCCNC(N)=O)CC2(C)C)=C1 CC1(C)C[C@@H1](NC(=O)[C@@H1]2CCSC2)CN(C(=O)C3=CC=CC(C(F)F)=N3)C1 CSCC[C@H1](O)CC(=O)N1C[C@H1](CNC(=O)CC(F)F)CC12CCC2 C[C@@H1]C1CC[C@H1](C(=O)N2CCOC3(CN(C(=O)OCC4=CC=C(Cl)C(Cl)=C4)C3)C2)C1 CCC1(C(=O)N[C@H1]2COC3(C2)CN(C(=O)C[C@H1](C)N4C=CN=C4)C3)CCCC1 CC1=CC=C2OC(C=NC=3C=C(I)SC=3C(=O)NC)=CC2=C1 C#CCOCCC(=O)N1C[C@@H1]2C[C@H1]1[C@@H1]2CNC(=O)C[C@@H1]3C[C@H1]3CC O=C(CC1CS(=O)(=O)C1)N2CCC[C@@]3(C2)CN(C(=O)[C@@H1]4CCOC4)CCO3 CC1=COC=C1C(=O)NC[C@H1](O)CCNC(=O)C=2C=C(CO)OC=2C CC(C)(C#N)CCC(=O)NCCCOCCNC(=O)[C@H1]1C[C@H1]2CCC[C@H1](C2)C1 CN1CCC[C@H1](CCN[C@@]2(C3=NN=NN3C(C)(C)C)C[C@@H1]4CCC[C@H1]4C2=O)C1 CNC(=O)[C@@H1](C1=CC=C(COC)S1)N(C)[C@@H1](C)C=2C=C(C)ON=2 C[C@@H1](CNC(=O)[C@H1](C)N(C)C(=O)C1=CC=C(F)S1)CN(C)C CC(C)(C)[C@H1]1CC(C(=O)NC[C@H1]2CN(C(=O)C3=CCS(=O)(=O)C3)CC2(C)C)=NO1 COCC[C@]1(C(=O)NCCN(C[C@H1](C)O)C(=O)C=2C=N[NH1]C=2)CC1(F)F CC(C)[C@@H1](C(=O)NCCOC1CN(C(=O)CCCCC(N)=O)C1)N2CCCC2=O CC(C)(O)[C@H1]1CCN([C@@H1](C(=O)NCCCF)C2=CN=C(C3=CC=CO3)S2)C1 COC1=CN=C(C(=O)NC2CN(C(=O)[C@H1](C)CC3CCC3)C2)C=N1 CP(C)(=O)CCC(=O)N(CCNC(=O)[C@@H1]1C[C@H1]2C=C[C@@H1]1O2)CC3CC3 COC1=CC=C(C2=CN([C@@H1](CCC(N)=O)C(=O)N3CCC[C@@H1](C)C3)N=N2)C(F)=C1 CC1=CC=C(CC(=O)N2CC(C)(C)OC[C@@H1]2CNC(=O)C3=CC=C(C)N=C3N)S1 COCCC(=O)NC[C@@H1]1CN(C(=O)[C@H1]2CC(=O)C3=CC=CC=C3O2)C[C@H1]1C CCOC1CC(C(=O)NCCCCC(C)(C)NC(=O)[C@H1]2CC[C@H1](CC)CC2)C1 CC1=CC=CC=C1CC(=O)N(C2=NC=NC=C2Br)[C@@H1]3CCNC3 COC1=CC=C2C(=C1)CN(CC3=CC=CC=C3C4=CC=CC=C4OC)CC2 CSC1=CC(C)=C(C(=O)NCCSCC2=CN(C3=CC=CC=C3CO)N=N2)S1 C[C@H1](NC(=O)[C@@H1]1CC12CN(C(=O)C(=O)C3=CC=CN3C)C2)C4=CC=C(C#N)C=C4 CNC1=NC=CC=C1C(=O)NC2CC3(CC[C@@H1](CNC(=O)[C@@H1](F)C(C)C)OC3)C2 CC=CCC(=O)N[C@H1]1C[C@@H1]2CC[C@H1](C1)N2C(=O)C=CC3=CN=CN3C CS[C@H1](C)CC(=O)N[C@@H1]1CN(C(=O)C=2C(C)=NOC=2C3CC3)C[C@H1]1C CO[C@H1]1CN(C(=O)[C@@H1]2CCC3=N[NH1]C=C3C2)C[C@H1]1NC(=O)[C@@](C)(OC)C4CC4 O=C(NCC[C@H1]1CCN(C(=O)C2=CC=C(F)C=C2F)C1)[C@@H1]3C[C@@H1]4CC[C@H1]3C45CC5 CN1CC[C@@H1](C(=O)N[C@H1](C(=O)NCCCCCO)C2=CC=CN=C2)C1 CC[C@H1](CO)N(CC1=CC=CO1)C(=O)[C@]23CCC[C@H1]2OCC3 COC1=NN(C)C=C1C(=O)NC[C@@H1](F)CNC(=O)C2=CC=C(N(C)C)C=C2 C=C(C)C[C@H1](OC)C(=O)N[C@@H1](CNC(=O)CC=1C(C)=NOC=1Cl)CC(C)C CC1=CC=CC(CC(=O)N2CC[C@@H1](NC(=O)CCNC(=O)C(C)(C)C)[C@@H1](O)C2)=C1 CC(C)(C)NS(=O)(=O)CC(=O)N[C@H1]1CCCC12CN(C(=O)[C@H1]3C[C@@H1](O)CN3C)C2 CN=C1[NH1]C(=NCC=2C=CN(C3=CC=CC=C3)N=2)[NH1]C(=N[C@H1]4CCO[C@H1](C)C4)[NH1]1 CN(C[C@H1](O)CN(C)C1=CC(O)=NC=N1)C(=O)C2=CC=C3N=NN(C)C3=C2 CC(=O)N1CCCC[C@@H1]1C(=O)N2CC(O)(CN(C)C(=O)[C@H1](C(C)C)N(C)C)C2 CCOCCNC(=O)[C@H1](C1=CC(CC)=CC=C1F)N2CC3=CN=C(C)N3C[C@H1]2C C[C@H1](CO)C(=O)N[C@@H1](CNC(=O)CC1CCC1)C2=CC=CC=C2Br CO[C@]1(CNC(=O)C2CCC(F)CC2)CCN(C(=O)CC[C@@H1]3C(C)(C)CCO3)C1 COC1=NC=NC=C1NC(=O)C[C@H1](C)CNC(=O)[C@@H1]2CCO[C@@H1]2C(C)C C[C@@H1](F)CC(=O)NCC1(NC(=O)C2=CC=C(N3C=CC=C3)C(F)=C2)CCC1 O=C(NCC[C@@]1(O)CCCN(C(=O)C2=CN=C(S)N=C2)C1)C3=CCCOC3 CCCC[C@@H1](NC(=O)[C@@H1](C)C(F)(F)F)C(=O)N(C)CC1(O)CCCC1 CCC=1[NH1]N=C(Cl)C=1[C@@H1](NC[C@@H1](COC)C(C)C)C2=NN=NN2C3CCCCC3 C[C@@H1](C(=O)N[C@H1](CNC(=O)C1=CC=C(C2=CC=C(F)C=C2)[NH1]1)C(C)(C)C)N(C)C O=C1C[C@@H1](C(=O)NCC[C@H1]2C[C@H1](NC(=O)[C@@H1](F)CC3CCCC3)C2)NC(=O)N1 CC(C)C[C@H1](CN=C1[NH1]N=CS1)NC(=O)[C@H1]2CCCCN2C3CCCC3 CCCCC[C@H1](C)NC(=NCCC(=O)N(C)C)NCC=1N=NN(C)N=1 CO[C@H1](C)C(=O)N1CCN(C(=O)C=CC2=CC=C(O)C=C2)C[C@H1]1C3CC3 COC[C@]1(C)C[C@@H1](NC(=O)CC2CC(F)C2)CN1C(=O)CCN3C=C(Cl)C=N3 CC1=NC=C(C(=O)N2C[C@H1](C)N(C(=O)C3=CC=C(N=[N+1]=[N-1])C=N3)[C@H1](C)C2)[NH1]1 CC(C)NC(=O)[C@H1](C1=CC=CC(OC2CC2)=C1)N3CCN(C=4C=C(Cl)ON=4)CC3 CCN(CCNC(=O)[C@H1]1CCN(CC(C)C)C1)C(=O)C2=CC(C)=C(C(F)F)C=N2 O=C(N[C@@H1]1CCN(C(=O)CC[C@@H1]2CCOC2)C13CC3)[C@@H1]4CCC5=C[NH1]N=C54 CCOC1=CN2C(=N1)CC[C@@H1](C(=O)N(C)[C@H1](C)CN(C)C(=O)CC(F)(F)Cl)C2 CC(C)CC[C@H1](O)C(=O)N[C@H1]1CCCCCC[C@H1]1NC(=O)C=2N=CSC=2C3CC3 COC1=CC(C(=O)N[C@H1]2C[C@H1](C)CN(C(=O)C3=CC(O)=CC(O)=N3)C2)=CN=C1O CCC[C@@H1](C)C(=O)NCC1=CC=C(NC(=O)C2=CC(C#N)=C3C=C[NH1]C3=C2)C=N1 CN1CC[C@H1](CC(=O)N[C@@H1]2CCC[C@H1]3CN(C(=O)C4=CC=C([N+1](=O)[O-1])O4)C[C@@H1]32)C1 COC[C@H1](CNC(=O)CC(C)C)NC(=O)C[C@@H1]1CCCC(C)(C)O1 CN(C)[C@H1](CO)C(=O)N1CC(O)(CCNC(=O)C2=CC=NC(N3C=CN=C3)=C2)C1 O=C(N1C[C@@H1]2[C@@H1](CCC[C@H1]2N=C3N=C4[NH1][NH1]C=C4C(O)=N3)C1)C5(CCO)CC5 CN(C(=O)[C@@H1]1CO[C@H1](CNC(=O)C2=CCCOCC2)C1)[C@H1]3CCC[C@@]3(C)O CO[C@@](C)(C1CC1)[C@@H1](C)NC2=CC(=NCC3=NC(Br)=N[NH1]3)[NH1]C(C(F)(F)F)=N2 O=C(NC[C@@H1]1CCCN1C(=O)CC2CC=CC2)[C@@H1]3C[C@H1]3C4=CC(F)=CC=C4F C[C@@H1]1CN(C(=O)CCOC[C@@H1]2CCCO2)CC[C@H1]1N(C)C(=O)C3=CC=NC=C3 NC(=O)C=CC(=O)N[C@@H1]1C[C@H1]2CC[C@H1]1N(C(=O)[C@H1]3CCOC4=CC=C(F)C=C43)C2 CSC1=CN=C(N[C@@H1]2CCN(C(=O)NCCCl)C2)N=C1 C[C@H1]1C[C@@H1](C(=O)N(C)CCNC(=O)CN(C)S(=O)(=O)C2=CC=CC=C2F)CCS1 CC[C@@H1](O)C(=O)N1CCN(C(=O)C=C(C)C2=CC=CC=C2C)[C@H1](CC)C1 CC1=CC(C(=O)N[C@H1]2C[C@@H1](O)[C@H1](NC(=O)C3=CC=C(F)C(C)=C3Cl)C2)=CO1 CC1(CNC(=O)C[C@@H1]2CCC[C@H1](O)C2)CCN(C(=O)CCC3=CC=CN=C3)CC1 C[C@@H1](CC1CC1)NC(=O)CCN(C(=O)C2=CN=CS2)C3CC3 CC(=O)C1=CC=C(C(=O)N2C[C@H1]3C[C@H1](NC(=O)C4(C)CC5(CC5)C4)C[C@H1]3C2)O1 O=C(N[C@H1]1CC[C@]2(CCCN(C(=O)[C@H1]3C[C@@H1](O)C3)C2)C1)[C@@]4(Cl)CC4(F)F COC(=O)[C@H1](C)NC(=O)[C@@H1](C[C@H1]1CCCCO1)N2C[C@@H1]3CCC[C@H1](C2)N3C CC1=CC=CC(C(=O)NCC[C@@H1]2CCN(C(=O)CC(C)(F)F)CC2(F)F)=C1C CC=1SC(C(=O)NCC2(O)CC(NC(=O)[C@@H1]3CCC(=O)N3CC)C2)=NC=1O C[C@H1](CC(C)(C)C)NC(=O)[C@]1(F)CCN(C(=O)C2(C)CCOCC2)C1 CCC1=NON=C1C(=O)NC[C@]2(C)CC[C@@H1](NC(=O)C=3C=C(C4CC4)[NH1]N=3)C2 COC1=CC(C2=CN=C(CNC(=O)CC3=CC=NC=C3)N=C2)=CN=C1F COC1=CC=CC(NC(=O)[C@H1]2CCC[C@@]23CCN(CC4=N[NH1]C=C4Cl)C3)=C1C C=C(CCNC(=O)[C@@H1]1[C@H1]2CCCO[C@H1]21)CNC(=O)[C@H1]3CCCCO3 COC1=CC(S(=O)(=O)F)=C(NC(=O)C2CN(CC3=CC=C(O)N=C3)C2)C=N1 CSCC[C@H1](NC(=O)C1=NC=NC(O)=C1F)C(=O)NC[C@H1]2C=CCCC2 CC(C)(C)C#CCCNC(=O)C1=CN(CCNC(=O)C(N)=O)C=N1 CCC(=O)N[C@H1](C)C(=O)NC(C)(C)[C@H1]1CCN(C(=O)C=2C(C)=NOC=2C3CC3)C1 CCC1=CN=CC=C1[C@H1](NC[C@H1](C)C2=CC=C(F)C=N2)C3=NN=NN3C4CC4 CN(C)C(=O)CCC(=O)N1CCC[C@H1]2[C@@H1]1CCN2C(=O)CCC3=CC=CC=N3 COC1(CC(=O)N2CCOC[C@@H1]2CCNC(=O)CC3=CN=CN=C3)CC1 CC[C@](C)(C#N)C(=O)N1CC[C@@H1]2CN(C(=O)C=3C(C)=NOC=3C4CC4)C[C@@H1]2C1 CC=C(C)C(=O)N[C@@H1]1CN(C(=O)CC2=CC(Cl)=CC(Br)=C2)[C@@H1]3C[C@@H1]13 CN(CCC(=O)N1CC[C@H1]2CN(C(=O)CC3CC3)C[C@H1]21)C4=CC=NC=C4 O=C(N[C@@]12C[C@@H1]1CN(C(=O)C(=O)C3=CC(F)=CC(Cl)=C3)C2)C4=CC=C(C(F)F)O4 CC1=CN=CC(OCC(=O)N[C@H1](CNC(=O)C#CC(=O)N(C)C)C(C)(C)C)=N1 CC1=CC(NC(=O)[C@@H1]2C[C@H1]3CCN(C(=O)C4CCC4)C[C@H1]32)=NC(C)=N1 CCCCCC[C@@H1](C)CC(=O)N1CC[C@H1]1CNC(=O)C2(CC)CCC2 C#C[C@]1(O)C[C@@H1](C(=O)N[C@H1]2CC[C@H1]2CNC(=O)[C@H1](COC)C3=CC=CC=C3)C1 CC1=CSC(C(=O)N(C)C[C@@]2(O)CCN(C(=O)[C@@H1](O)C(C)(C)C)C2)=C1 CC1(C)CC(C(=O)N2CC(CNC(=O)CC=3N=C[NH1]N=3)C2)(C4=CC=C(F)C=C4)C1 COC(=O)[C@H1]1C[C@H1](C(=O)NCC2=NC3=C(S2)COC[C@H1]3C(=O)OC(C)(C)C)C1 CCC=1C=COC=1C(=O)N[C@@H1](C(=O)NC2(C=3N=N[NH1]N=3)CC2)C4=CC=CS4 CC[C@H1](C)CN(C)C(=O)CCCCCCNC(=O)C1=CN(C)C=CC1=O CN1N=CC(S(C)(=O)=O)=C1C(=O)N[C@H1]2CO[C@H1]3CN(C(=O)CC4CC(=O)C4)C[C@@H1]23 O=C(NC[C@@]12C[C@H1]1CN(C(=O)CC3=CC=C(Cl)C=N3)C2)C4=N[NH1]C5=C4COCC5 CS(=O)(=O)CC(=O)NCCC(CNC(=O)C1[C@@H1]2CS(=O)(=O)C[C@@H1]12)CC CC=1N=C(CCC(=O)N[C@@H1]2CN(C(=O)[C@H1]3C(C)(C)C3(F)F)C[C@H1]2C4CC4)OC=1C CC1=NC(CC(=O)NC[C@@H1](C)CN(C)C(=O)C2=CSN=C2Cl)=CS1 CC1CC(CCC(=O)N2CC(C3(NC(=O)[C@H1](C=4C=NN(C)C=4)C(C)C)CC3)C2)C1 CSCCCN=C(NCC1=CC=C(NC(C)=O)N=C1)NC[C@H1](O)CS(C)(=O)=O C[C@@](CO)(CNC(=O)C1=CN(CCCF)N=N1)NC(=O)/C=C/C2=CC=C(Cl)S2 CC1=CN=CC=C1C(=O)N2CCO[C@H1](CNC(=O)C3=CC=C4C=NC=CC4=C3)C2 CC[C@@H1]1[C@H1](C(=O)N2CC=C(C)C2)CCCN1C(=O)[C@H1](O)CC(N)=O CCC1=C[NH1]C=C1C(=O)NC2CN(C(=O)CSC3=CC=CC(F)=C3C(=O)OC)C2 COCC(C)(C)CC(=O)NC[C@](C)(CO)NC(=O)[C@@H1](C)C1=CC=CC=C1OC C[C@@H1](C(=O)N(C)[C@H1](CNC(=O)C1=CSC(Cl)=N1)C2CC2)C3=CC=CC(F)=C3 CN(C(=O)COC=1C=NN(C)C=1)[C@H1]2CCC[C@@H1](NC(=O)CCC(C)(C)[N+1](=O)[O-1])C2 CC1=CC=C([C@H1](NC(=O)CC=2C=NN(C)C=2)C3CC3)C=C1 CC12CC(C(=O)N3CC[C@@H1]([C@@H1](C)NC(=O)CCC4=CC=C(Br)N=C4)C3)(C1)C2 CC(=O)NC1=CN=CC=C1C(=O)NC[C@@H1]2CC[C@H1](NC(=O)C3=CCCC3)C2 CCC1=CSC(C(=O)N2CC3=CC=C(C4=CC(F)=C(F)C=C4F)C=C3C2)=N1 COC1=CC(Cl)=CC=C1C(=O)N[C@@H1]2CC[C@H1]3CN(CCS(C)(=O)=O)C[C@@H1]3C2 CC1=C(C(=O)N2CCSC[C@H1]2CCNC(=O)CSCC(N)=O)CCC1 C=CC[C@]1(C(=O)N2CC[C@@H1](N3C=NN=N3)C2)CCCN1C(=O)CCCCC#N CC(C)(C(N)=O)C(=O)N1CC2(CC[C@H1](CNC(=O)[C@H1](F)C(F)(F)F)O2)C1 CC1=NC(N2C[C@H1]3C[C@H1]2CC[C@@H1]3NC(=O)C4=CC5=C(S4)CCCCC5)=NC=C1Br C[C@@]1(NC(=O)C2=CC=C(C(N)=O)C(Cl)=C2)CCN(C(=O)[C@@H1]3[C@H1]4CCCC[C@H1]43)C1 CC[C@H1](C(=O)NCC1[C@H1]2CN(C(=O)C3=N[NH1]C4=C3CCCC4)C[C@H1]12)C(C)C COC[C@H1](O)C(=O)N1CC=C(CNC(=O)CC[C@H1]2CC2(F)F)CC1 CC[C@@H1](C(=O)NC[C@H1]1CN(C(=O)C=2C=NN(C)C=2COC)CC3(CCC3)O1)N(C)C O=C(C1=CC=C(I)C=C1O)N2C[C@H1]3[C@@H1](C2)N3S(=O)(=O)CC4=CC=C(F)C=C4F CC1=CC(Cl)=CC=C1O[C@@H1](C)C(=O)NC2(CN(C)C(=O)CCC(C)C)CC2 CCN(CCC(=O)N(C)CCC1=CC=CN=C1)C(=O)[C@@H1](C)C2CC2 CSC[C@@H1](O)C(=O)N[C@@](C)(CO)C(=O)N[C@H1](C)CCC(F)(F)F CC1=CC(N2CCC[C@@H1]2CNC(=O)CN3C=C(Cl)C=N3)=NC(CO)=N1 C=CCCCCCCCCC(=O)N1CC(N(C)C(=O)CC2CCSCC2)C1 CCC1(C#CC(=O)NC[C@@H1]2C[C@@H1](NC(=O)C(F)=C3CCCC3)CCO2)CC1 CNC(=O)[C@@H1]1C=C[C@@H1](NC(=O)CCCN(C)C(=O)[C@@H1]2SCC=C2C)C1 CCOC(=O)N1CCC[C@@H1](C(=O)N[C@](C)(CO)CNC(=O)CNS(N)(=O)=O)C1 COCCS(=O)(=O)N1C[C@H1](F)[C@@H1](NC(=O)C2=CC=C(Cl)C(C)=C2Cl)C1 CCC1=CC=C2[NH1]C(C(=O)N[C@@H1](CO)CNC(=O)C(=O)NOC)=C(C)C2=C1 CC(C)NC(=O)C(=O)N[C@@H1]1CN(C(=O)C=2C=CN3C=NN=C3C=2)C[C@@H1]1C CCC1=NC(C)=C(CNC(=O)C2=CC=C(C)C(Br)=C2N)S1 CC1=C[C@@H1]1C(=O)NC[C@@H1]2CCCC[C@@H1]2NC(=O)[C@@]34CC[C@@](C)(C3)OC4 NC1=CC=CN=C1C(=O)N2CC[C@@H1](N3CCN(C(=O)[C@@H1]4C[C@H1]4CF)CC3)C2 CN1N=C(C(=O)NCC2(NC(=O)[C@@H1]3C[C@@H1]3CF)CCCC2)C4=CC(F)=CC=C41 CO[C@@]1(C(=O)NC2CCC(C(=O)N3CCCCN(C)CC3)CC2)CCOC1 CS[C@@H1](C(=O)N1CCC[C@@]1(C)C(=O)NC[C@@H1]2CCC(C)(C)O2)C3CC3 CC1=CC(C(C)C)=CC=C1C(=O)NC[C@@H1](C)CN(C)C(=O)C2=CC(Cl)=C(Cl)N2C CC1=CC(C(=O)N2C[C@@H1]3C[C@H1]2[C@@H1]3NC(=O)C4=CCCS4)=C(O)C(C)=N1 C[C@H1](O)CCCC1N(C=NC2=CC=C(S(=O)(=O)N3CC=CCC3)C4=C2SCC4)CC1 CC=1C=CSC=1C(=O)N2CC[C@H1](CNC(=O)C3=CC(C(C)(F)F)=N[NH1]3)C2 C#CCCC(=O)N(CC)CCN(CC)C(=O)[C@H1]1CCC2=CC=C(OC)C=C21 C[C@H1](CCNC(=O)C1CCC(C)(C)CC1)N(C)C(=O)[C@@H1]2CCCCCS2(=O)=O CCCC=C(CC)C(=O)NCC[C@@](C)(CC)NC(=O)CN1N=CN=N1 CC1=CC=C(C)C(NC(=O)[C@H1](C)SC2=NN=C(N3CCCCC3)N2C4CCCC4)=C1 CC[C@H1](CC(=O)N1CCC[C@H1]2CN(C(=O)C=CC3=CN=CS3)C[C@H1]21)SC COCC1=NC(CC(=O)NCCC(C)(C)CNC(=O)C(C)(C)CN(C)C)=CS1 C=C=C(C)CC(=O)NCCN1CCN(C(=O)[C@H1]2CCN(C3=NC=CN3C)C2)CC1 CCC=1OC=C(C)C=1C(=O)N[C@@H1](CCOC)CNC(=O)CNC(=O)NC CC1=CC(C)=C(S(N)(=O)=O)C=C1C(=O)NC[C@@H1](F)CNC(=O)[C@@H1]2C[C@H1]3CC[C@@H1]2O3 C=CCCOCC(=O)N1CC[C@H1](C2CC2)[C@@H1]1CNC(=O)[C@@H1](O)[C@H1](C)CC C[C@H1](CN(C)C(=O)[C@@H1]1CC2=NC=CN2C1)NC(=O)[C@@H1]3NC(=O)C[C@H1]3C CC[C@]1(C(=O)N[C@@H1]2CCN(CC3=CC(C)=CC(C)=C3)C[C@H1]2C)CC1(F)F CC1=NOC=C1CCC(=O)N2CC3=C(C2)CN(C(=O)[C@@H1](F)C4CCCCCC4)C3 CN1C=C(C(=O)N2C[C@H1](C(=O)NC3(C(F)F)CCC3)C(F)(F)C2)C=CC1=O CCOC(=O)[C@H1](OC(=O)C1=C(C)N=C2SC(C)=NN12)C3CCC3 COC1=CC=C([C@@H1](CCO)N=C2N=C3SC=CC3=C(N[C@H1](C)CC#N)[NH1]2)C=C1 C[C@H1]1[C@@H1](NC(=O)C#CC(C)(C)C)CCN1C(=O)COC2=CC=C(F)C=C2Cl CCS[C@@H1](C)C(=O)N1CC(C)(C)CC[C@H1]1CNC(=O)C2=CN=CC(C(C)C)=C2 CC1CN([C@@H1](C)C(=O)NCC2(CN(C)C(=O)C[C@H1]3CCC(F)(F)CO3)CC2)C1 O=C(NC[C@@H1]1C[C@@H1](O)[C@H1](NC(=O)[C@@H1](O)C2=CC(F)=C(F)C=C2F)C1)C=3C=COC=3 CC1=CC(CC(C(=O)NC/C=C/CNC(=O)C2=CC=C(Cl)O2)CC)=CC=C1F CC(C)C[C@@H1](C)C(=O)NCC[C@H1]1CCCN(C(=O)C2=CC=C(CCF)C=C2)C1 COCC(=O)N1C[C@@H1](NC(=O)C2=C(C)S(=O)(=O)CC2)C[C@@H1](F)C1 CCSCCC(=O)NCC1(O)CC(C(=O)NC[C@@]2(C)CCCCO2)C1 CC(C)CCCCC(=O)N[C@H1]1CS(=O)(=O)C[C@@H1]1NC(=O)C2=CC=C(C(C)C)N=C2 O=C(NCCC1=CC=CC(CO)=C1)C2=NC=NC=C2C3=CC=C(C4(O)COC4)C=C3 COCC[C@H1](NC(=O)C[C@H1](C)CC(C)C)C(=O)NCCC(=O)OC C=CCOC[C@@H1](C(=O)NC1CC2(CCN(C(=O)C[C@@H1]3CC3(Cl)Cl)C2)C1)C(C)(C)C COC1=CC2=C(C(C(=O)N(C)CCOCCNC(=O)COC(C)=O)=C1)O[C@H1](C)C2 CCC(=O)N1CCC([C@H1](CNC(=O)COC2(C)CCC2)C3=CC=C(F)C=C3)CC1 CCCC[C@@](C)(F)C(=O)N[C@H1]1COCC[C@H1]1NC(=O)C2(C3=CC=CC=C3F)CC2 CS[C@H1](C)CC(=O)N[C@@H1]1CCN(C(=O)C2=C[NH1]C3=CC=C(Cl)C=C23)C1(C)C CC1=CC=C(CN(C)C[C@@H1]2CC3=CC=CC=C3CN2C(=O)C=4[NH1]N=NC=4C)C=N1 CC=1N=CSC=1C(=O)NC[C@H1]2[C@@H1](C)CCCN2C(=O)CC3CC4(CC4)C3 CC(C)[C@H1](C#N)C(=O)N1CC[C@](F)(C(=O)N[C@@]2(C)CC2(C)C)C1 O=C(CC1=CN2C(=N1)CCCC2)OCCCOC3=CC=CC(C(F)(F)F)=C3 CN1C=C(C(=O)C(=O)NC/C=C/C(=O)NC[C@@H1]2CCC(=O)O2)C=N1 CN(C)C(=O)C#CC(=O)N[C@@H1]1CCC[C@H1](NC(=O)CC=2C=CON=2)CC1 CSC1=CC=C(O)C(C(=O)N2CC(CNC(=O)C3=C(Cl)C=NN3C)C2)=C1 O=C([C@H1]1CCC(F)(F)C1)N2CCC(F)(C(=O)N3CCC=4SC=CC=4C3)CC2 CC1=CC=CN=C1CCC(=O)NC[C@@H1]2[C@H1]3CCC[C@H1]2N(C(=O)CN4C=NC=N4)C3 CC1=CC(C(=O)N2CC(C3CN(C(=O)CCS(C)(=O)=O)C3)C2)=C(C)O1 O=C(CC1=CC=NC(Br)=C1)N2C[C@H1]3[C@@H1](C2)[C@@H1]3C(=O)N4CCC5(CCOC5)CC4 CCOCC(=O)N(C(=O)CCC1=CC=CC=C1C(F)(F)F)[C@H1](C)C2=CC=CC=C2 CC[C@H1](C)[C@H1](CO)CNC(=O)[C@H1]1CCCN1C(=O)[C@@H1](C)SC CCC1=NC=C(C(=O)N[C@H1]2CN(C(=O)C3=NC=NN3C(C)C)C[C@@H1]2C)S1 COC(C)(C)C(=O)N1[C@H1]2CN(C(=O)C3=CC=CC(I)=C3C)C[C@H1]21 CC1=CC(C)=C(S(=O)(=O)N2CCC[C@H1](C(=O)N3CCCC[C@H1]3CCO)CC2)C(C)=C1 C#CCC(CC#C)C(=O)N[C@H1]1CCN(C(=O)[C@@H1]2C[C@@H1]3C[C@@H1]3C2)[C@@H1]1CC CC[C@H1](N=C1[NH1]C(=N[C@@H1](C)C=2C=C(C)OC=2C)[NH1]C=3C=C[NH1]C1=3)C4=CC=NC=C4 CO[C@]1(C(=O)N2C[C@H1]3[C@@H1](C2)[C@@H1]3C4=CN([C@@H1]5C6C[C@@H1]7C5[C@@H1]7C6)N=N4)CCSC1 CCCCC(=O)NC[C@@H1]1C=2C=CSC=2CCN1C(=O)[C@@]34C[C@@H1](OC)[C@@H1]3C4 CCS(=O)(=O)N1C[C@@H1]2CCN(C3=NC=CC(C(F)F)=N3)[C@@H1]2C1 CCC1=CN=CC(C(=O)N[C@H1](C(=O)N(CC)CCOCCO)[C@@H1]2CC=CCC2)=C1 CC1=CN=CC(C(=O)N2CC(F)(CNC(=O)CNC(=O)[C@@H1]3C[C@@H1]3C)C2)=N1 CC[C@@](C)(F)C(=O)NC[C@@]1(O)CCN(C(=O)C=C(C)C2CCCCC2)C1 CCC(CC)CNC(=O)C[C@@H1]1N(C(=O)CC2=CC=C(O)C=N2)CCC1(C)C C[C@H1](O)C(=O)N1C[C@@H1]2[C@@H1](C1)N2C(=O)OCC3=CC=CC=C3 CCOCCC(=O)N[C@@H1](CC1=CC=CC=C1)CN(C)C(=O)C(C)(C)C(F)F CC1(C)CC(=O)NC[C@@H1]1C(=O)NC[C@@]23C[C@@H1]2CN(C(=O)C4=CC=CC(=S)N4O)C3 C[C@H1](O)CCN(C)C(=O)[C@H1](C)N(C)C(=O)[C@H1]1C[C@@H1]2CCC[C@@H1]2C1 C#CC1=CC=CC(C(=O)N2[C@H1]3CN(C(=O)C4=CC(Cl)=C(Cl)C=N4)C[C@H1]32)=C1 CC=1N=NN(C)C=1C(=O)N2C[C@@H1](NC(=O)C[C@@H1]3CCCN3C)[C@H1](C(F)F)C2 NC1=CC=C(C(=O)N2CC3(CCC3NC(=O)C=CC4=CC=CC=C4Cl)C2)C(Cl)=C1 CC1=CC(C(F)(F)F)=NC=C1C(=O)N[C@@H1]2CCCN(C(=O)C3(C)CC3)CC2 COC1=CC=C(Cl)C=C1NC(=O)[C@H1]2C[C@H1]2NC(=O)CCC3=CC=CC=C3 CN1CCC[C@@H1]1CC(=O)N2CCN(C(=O)CC(F)(F)F)[C@H1](CC(C)(C)C)C2 O=C(N[C@H1](CC1CCOCC1)C(=O)NCC2=CC=NS2)C3=CC=CC=C3 CC1(C)CCC[C@@H1]1C(=O)NCC[C@H1]2CCCCN2C(=O)[C@@H1]3CCSC3 CC[C@H1](C)N1CCC(CN=C2C=C(C)[NH1]C(=NCC3=N[NH1]C4=C3CCC4)[NH1]2)CC1 C[C@H1](O)C(=O)N1CC[C@@H1]2CN(C(=O)C=3[NH1]N=NC=3C(F)F)C[C@@H1]2CC1 CC1=CC=CC(CNC(=NCC2=CC=C3C(=C2)OC(F)(F)O3)N[C@@H1]4C[C@H1]4C)=C1 CCC(CC)[C@H1](CNC1=NC=C(C)C=C1S(=O)(=O)NCCC(C)C)OC O=C(CC1=CC=NC=C1Cl)NC[C@]2(NC(=O)C3=CC=C4OC=CC4=C3)CCOC2 CC(C)N1C=C(C(=O)N[C@H1]2C[C@@H1](C(=O)NCCOCCF)C23CCCC3)N=N1 CC1=NN(C)C=C1CN(C)C(=O)C[C@@H1]2CCN(C(=O)CSCC(F)F)C2 CCN1N=CC(CN(C)C(=O)C(C)(C)C2=CC=C(Cl)C(Cl)=C2)=C1C CC=1N=C(Br)OC=1C(=O)NCC[C@H1]2C[C@@H1](NC(=O)[C@@H1]3C[C@]34CCCOC4)C2 CSC1=CSC=C1C(=O)NC[C@@H1](CO)NC(=O)C2CC(=C3CCC3)C2 CC[C@@H1]1CCN(C(=O)C=CC2=CN=CN2C)[C@@H1]1C(=O)N[C@@H1](C)CC3=CC=CS3 CO[C@@H1](C)CCC(=O)N1CC(CO)(NC(=O)C2=CSC(C=3N=C[NH1]N=3)=N2)C1 CCC=1OC=CC=1C(=O)N2C[C@@]3(CNC(=O)[C@H1](C)OC[C@@H1]4CCCO4)C[C@H1]2CCO3 CC1=NSC(NC2CC2)=C1C(=O)N[C@H1]3CCN(C(=O)CCC4CCOCC4)C3 CN(C(=O)C1=CC(F)=C[NH1]1)C2CCC(NC(=O)[C@@H1]3C[C@@H1]3C#N)CC2 CCN1N=CC(C(=O)N2CC[C@@H1](NC(=O)C=CC3CC3)C(C)(C)C2)=C1C(F)(F)F C[C@H1](C(=O)N(CCS(C)(=O)=O)C1CC2(CCNCC2)C1)N3C=NN=N3 CN(CC(=O)N1CC[C@H1]2C[C@@]2(C(=O)N3CCCCC(F)(F)C3)CC1)C4CC4 CP(C)(=O)CCC(=O)NCCC[C@@H1]1CN(C(=O)[C@H1]2CCCN2C3CC3)CCO1 CO[C@H1]1C[C@@H1](C(=O)N2CCC[C@H1](NC(=O)C=COC3=CC=C(OC)C=C3)CC2)C1 C[C@@H1](CCCO)N=C1[NH1]C2=C(C(=NC[C@H1]3CC4(CCC4)CCO3)[NH1]1)COC2 O=C(C[C@@H1]1C=CCC1)N[C@]23CCC[C@H1]2CN(C(=O)C4=CC(Br)=CC=C4F)C3 COC[C@H1](O)C(=O)N[C@@H1]1CCN(C(=O)C2=CC=C(CNC(=O)OC(C)(C)C)O2)C1 C=C[C@H1](C)[C@H1](C)C(=O)N1CC(C=2OC=NC=2CNC(=O)C=C(Cl)Cl)C1 C=CC(F)(F)C(=O)N1[C@H1]2CCC[C@H1]1CC(NC(=O)C3=NC(C)=NN3C)C2 CCN(CC1=CC=CC(C(F)(F)F)=C1)[C@H1](C(=O)NC(C)C)[C@H1](C)C(C)(C)C CO[C@@H1]1CN(C(=O)C=2SN=NC=2C(C)C)C[C@@H1]1NC(=O)C3C(C)(C)OC3(C)C C=C[C@H1]1CCCCN1C(=O)[C@H1]2CCCCCN2C(=O)CNC(=O)NC CCOC1=CC=C(CCC(=O)N(C)[C@@H1](C)CNC(=O)C2(C(C)C)CC2)C=C1 COC(=O)C1=C[NH1]C(C)=CC1=N[C@@H1]2CCCC[C@@H1]2CNC(=O)[C@H1](C)NC(C)=O CC1(C)[C@H1](C(=O)N2CC[C@](C)(O)C2)CCN1C(=O)[C@@H1]3CC(=O)NC(=O)N3 CO[C@H1]1C[C@H1](NC(=O)[C@@H1]2CCCN(S(N)(=O)=O)C2)CN(C(=O)CSC(C)(C)C)C1 COC1=CC=C2[NH1]C=C(C(=O)NCC3CN(C(=O)[C@@H1](O)C4=CC=CC=C4)C3)C2=N1 C[C@@H1]1CC[C@H1](CNC(=O)CC2(C)CC2)CN1C(=O)C=3N=C4N(C=3Cl)CCCC4 CC[C@]1(N(C)C)CCN(C(=O)[C@@H1]2CN(C(=O)CCC(=O)N(C)C)C3(CCC3)C2)C1 CC1=NSC(N)=C1C(=O)N[C@@H1]2C[C@H1](C)N(C(=O)C3=CC=C(C(F)(F)F)C(F)=C3)C2 CSC1=CC=C(CNC(=O)CC2(NC(=O)C3CCC=CCC3)CCCCC2)O1 C=CCCC1(C(=O)NCCCNC(=O)CC2CC(C)C2)CCCC1 CC1(C(=O)N[C@H1]2CCOC[C@H1]2NC(=O)C(=O)C3=CC(C(F)(F)F)=CC=C3)CCC1 CC1=NC([C@H1]2CCN([C@@H1](C(=O)NC3=CC=CC=C3)C4=CC=CC(Br)=C4F)C2)=N[NH1]1 COC(=O)C[C@H1](C)C(=O)N1CCN(C(=O)C[C@@H1](C)OC)[C@@H1](C2CC2)C1 COCCN(C)CC(=O)N1C[C@H1](C)CC[C@H1]1CNC(=O)C2=CC=CC=3ON=CC2=3 CC(C)CCO[C@H1](C)C(=O)N[C@@H1](C)CCNC(=O)[C@@H1]1OCCCC1(C)C COC1CC(C(=O)N2CCC[C@](O)(CNC(=O)C3=NNC(=O)C3)CC2)C1 CCCOCC(=O)N[C@@H1](C(=O)N[C@@H1](CC(N)=O)C1CC1)C2=CC=CN=C2 C[C@@H1]1CC(C(=O)N2CCC3(CCC[C@@H1]3NC(=O)C4=C(Cl)CCOC4)CC2)=NO1 CCNC(=O)C1=CC=C(C2=CC=C(CNC(=O)C3=CC(C)=CC(C)=C3)N=C2)C=N1 CCCN(C(=O)CCN1C=CC=N1)[C@H1](C)C(=O)N(C)CC(F)=N CCC1CC(C(=O)N2CC=C(C(=O)NC3([C@@H1](O)CO)CC3)C2)C1 CC=1C=NOC=1C2(C(=O)N3CC[C@@H1](O)[C@H1](NC(=O)C4(CF)CCC4)C3)CC2 O=C(O)C[C@@H1]1CCC[C@H1](NC(=O)C2=CC(F)=C(Br)C(F)=C2)C1 C#CC[C@H1](C)N(C)[C@H1](C(=O)NCC1=CC=CC(OC)=C1)[C@H1]2C[C@@H1]2C3=CC=C(C)O3 C[C@@H1]1C[C@@H1]1C(=O)NCCC(=O)NCC2=CC=C(CNC(=O)C=C3CCC3)C=C2 CC1=NSC=C1C(=O)N[C@H1](CC2=CC=C(Cl)C=C2)C(F)F C[C@H1]1CCO[C@H1]1CNC(=O)[C@@H1]2C[C@H1](F)CN2C(=O)[C@H1]3CCNC3=O CO[C@H1]1C[C@@H1](C(=O)NC[C@@]2(C)CCCN2C(=O)[C@@H1]3CCCOCC3)C1 O=C(NC1=NC=C(F)C=C1O)[C@@H1]2C[C@@H1](F)CN2CC3=CC=C(C4=CC=CS4)C=C3 CC1=CC(C(=O)NC23CC(C)(C2)OC34CCN(C(=O)[C@@H1]5CCCC[C@H1]5O)CC4)=N[NH1]1 CC(=O)C1=CC=CC(C(=O)N(CCO)C2=CC=CC=C2C)=C1 O=C(C[C@@H1]1CCN(C(=O)CCN2CCCCC2)C1)NC=3C=CC4=NC=NN4C=3 N#CC1=CC(=NC(=O)[C@@H1]2CN(CCC3=CC=CC=C3Cl)CC2(F)F)[NH1]O1 CC(C)CC(C(=O)N[C@@H1]1CN(C(=O)[C@@H1](O)C(F)(F)F)CC1(C)C)C2=CC=CC(F)=C2 C#CC1=CC=CC=C1CC(=O)N2CCC[C@]3(NC(=O)[C@H1]4CC(=O)N4)CCC[C@@H1]23 C=C(Cl)C[C@@H1](N)C(=O)N1CC[C@H1](S(=O)(=O)C(C)(C)C)C1 CC(=CC(=O)N1CCC[C@H1]1C2CCN(C(=O)CCC(C)(C)F)CC2)C(F)F CS[C@@H1](C)CCC(=O)N1[C@H1]2CC[C@H1]1CN(C(=O)CS(C)(=O)=O)C2 C[C@@H1](NC(=O)[C@]1(C)CCCN1C(=O)C2=C(F)C=C(Br)C=C2F)C3=CC=C(Br)C=C3 CCC1=CC=CC(C(=O)N[C@@H1]2CN([C@@H1](C)C3=NN=CN3C)CC4(CCC4)C2)=N1 C[C@@H1]1CN(CC2=CC(Cl)=CC(Cl)=C2)CCN1C(=O)C3CC4(CCOCC4)C3 CN(C(=O)C1=CC=CC(F)=C1Br)[C@@H1]2CC[C@@H1](NC(=O)C=3C=C[NH1]C(=N)C=3)C2 O=C(N[C@@H1]1CCC[C@@H1](O)C1)C2CCN(C(=O)CCC3=CC=C4C=CC=CC4=N3)CC2 CCC1=NN(C)C=C1C(=O)NCC[C@@H1]2CN(C(=O)C3=C(N)C=CC=C3F)C[C@H1](C)O2 O=C(O)C[C@H1]1C[C@H1](NS(=O)(=O)CC2=CC=CC=C2Cl)C1 CCC1O[C@@H1]2CC[C@H1](C(=O)N[C@@H1]3COC(C)(C)C3)C[C@H1]21 O=C(N[C@H1]1CN(CC2=CC=C(Cl)C(Cl)=C2)C[C@H1]1F)C3=C[NH1]C4=CC=CC=C34 O=S(=O)(C1=CC=C(I)C=C1)N([C@H1]2CC[C@@H1](O)C2)[C@@H1]3C[C@H1]4CN[C@H1]3C4 O=C(N[C@@H1]1CCC[C@H1](C(=O)N2CCN3C(Br)=NN=C3C2)CC1)C4=CN=NC(O)=C4 C#CCN(CCC(=O)N[C@@H1]1C[C@H1]2C[C@H1]1[C@H1]3C[C@H1]32)C(=O)C=4C=C(C)SN=4 C=C[C@H1](C)CC(=O)N[C@@H1](C)C1(O)CN(C(=O)C2=NN=C(O)C=C2C)C1 CCOC(=O)[C@@H1](CC)C(=O)N[C@H1](C)CNC(=O)C1=CSC=N1 CN(C(=O)C1=CC=NO1)C2CN(C(=O)C3=CC=CC=C3C(C)(C)C)C2 C[C@@H1]1OCC[C@@H1]1CC(=O)N[C@@H1](CC(F)F)C(=O)N[C@@H1]2CCCC[C@H1]2F C[C@]1(CNC(=O)[C@H1](N)C2=CC=C(SC(F)(F)F)C=C2)CCC(=O)N1 CN(C[C@H1](F)Cl)C(=O)C1(N2C=C(CN3CCCCC3=O)N=N2)CCOCC1 CC(=CC(=O)NC[C@@H1](C)CNC(=O)[C@@H1]1[C@H1]2CCCO[C@H1]21)C3=CC=CC(Cl)=C3 CC1CCC(C(=O)N2CC(C)(NC(=O)C3=CC=C4N=C(S)[NH1]C4=C3)C2)CC1 C=CC1CN(C(=O)[C@@](C)(C2CC2)N(C)C(=O)CCC3=CC=CC=N3)C1 CC(=CC(=O)NCCN(C(=O)C1=CC=C2C=CC=C(F)C2=N1)C(C)C)C(F)F CC1=C(C(=O)N2CC[C@H1](C3CN(C(=O)[C@@H1]4CNC(=O)CC4(C)C)C3)C2)N=CN1C CC1=CON=C1C(=O)N[C@H1](C)CCCNC(=O)COCC2=NC(C3CC3)=NO2 CC(=O)C=CC(=O)N1CCO[C@@H1](C)[C@@H1]1C2=CC=CC=C2 O=C(CCC(F)(C1=CC=CC=C1)C2=CC=CC=C2)NCCC3CNC3 C=CC[C@]1(C(=O)NC[C@H1](C)CN(C)C(=O)C(C)(C)C2=CC=CC(Cl)=C2)CCOC1 CCC[C@H1](NC(=O)C=1[NH1]C=C(C)C=1C)[C@@H1](O)C(=O)N2CCCCO2 CCC[C@H1](NC(=O)C1=CCCC[C@@H1]1C)[C@H1](O)C(=O)NCC2=NC=CC(C)=N2 FC1=C(Cl)N=CC(Br)=C1CN[C@H1]2CCCO[C@H1]2CCCCC COC[C@@]1(NC(C)=O)CCN(C(=O)[C@H1]2CCCN(C(=O)C3=CC=CO3)C2)C1 CC1=CC(C(=O)N[C@@H1]2CC[C@H1]2CNC(=O)CC[C@@H1]3C[C@H1]4CC[C@H1]3C4)=NN1C O=C(NC[C@H1]1[C@@H1]2C[C@H1]1CN2C(=O)CSCCC(F)(F)F)C3=CC4=C[NH1]N=C4S3 C#CC1=CC=C(C(=O)N[C@@H1]2C[C@H1](OC)CN(C(=O)C3(C(N)=O)CC3)C2)C(OC)=C1 CCCN1C=CC(C(=O)N(C)CCCCCCNC(=O)CC2=CN=NS2)=C1 C#CCN(C(=O)CCS(C)(=O)=O)C1CCN(C2=NC=NC(C)=C2OC)CC1 C[C@@H1](CC=1C=NN(C)C=1)C(=O)N2C[C@@H1]3C[C@@H1]3[C@@H1](NC(=O)C4=NC=CN4C)C2 CC[C@@H1]1CN(C(=O)C2=NC(COC)=NO2)CC[C@H1]1NC3=CC(O)=NC(=O)N3C CCS(=O)(=O)N1CCC(C(=O)N(C)CC2(NC(=O)[C@@H1]3CCC[C@@H1]3OC)CC2)CC1 C#CCCCCCC(=O)NC[C@]1(O)C[C@@H1]2CC[C@H1](C1)N2C(=O)C3CC=CC3 COC=1C=C(C(=O)NCC[C@H1]2CC(F)(F)CN2C(=O)C3=CN=C(C)C(C)=C3)ON=1 CC1=C(C(=O)NC2(C)CCN(C(=O)CC3=C[NH1]C4=CN=CC=C34)CC2)CCCC1 C#CCNC(=O)[C@H1](CCC#C)NC(=O)[C@H1]1CCCC(C)(C)C1 C[C@@H1](CC1CN(C(=O)CC2=CC=CC3=CC=CC=C23)C1)NC(=O)[C@@H1](C)NC(N)=O C=CCSCC(=O)N1C[C@H1](F)[C@H1](N(C)C(=O)CCSC2=CC=C(C)C(C)=C2)C1 CC(C)CCC[C@H1](C)C(=O)N1C[C@H1]2CC[C@H1]1C[C@H1]2NC(=O)C3=CC(C(C)C)=NO3 CCN1C=C([N+1](=O)[O-1])C(C(=O)N[C@H1]2C[C@@H1]3CN(C(=O)COCC(C)C)C[C@@H1]3C2)=N1 CSC1=CN=CC(C2=CN=CC=3SC(C(=O)N4CCC(C)(OC)CC4)=CC2=3)=C1 CC=1OC(C(=O)NC[C@H1]2CC[C@@](C(=O)NCC3=NN=CN3CC)(C2)C)=CC=1CO O=C(C(=O)C1=CC=CO1)NC[C@@H1](CNC(=O)C2(C(F)F)CCOCC2)C(F)(F)F O=C(C1=CCCOC1)N2C[C@H1]3CCN(C(=O)[C@@H1]4CCNC4=O)[C@H1]3C2 O=C(N[C@@H1]1[C@H1]2C[C@@H1]1N(C(=O)[C@@H1]3C[C@]34CCOC4)C2)C5=CC=C6[NH1]N=C(Cl)C6=C5 CC1=COC=C1C(=O)N2C[C@H1]3[C@@H1](NC(=O)[C@H1](NS(N)(=O)=O)C(C)C)CO[C@H1]3C2 O=C(C1CNC1)N2CCC[C@H1](N3C=C(C4=CC=CC=5N=C(O)[NH1]C4=5)N=N3)CC2 CC1=CSC(C(=O)NC[C@@H1]2CC[C@H1](NC(=O)C3=CN(C)C(=O)N3C)C2)=C1 CC1=C(C(=O)NC2C[C@@H1]3CCC[C@H1](C2)N3C(=O)CN(C)S(N)(=O)=O)CCO1 CC1(C)[C@H1](O)C[C@@H1]1CC(=O)NC[C@H1]2CC[C@H1](NC(=O)C3(Cl)CC3)C2 C[C@@H1](CC=1C=NN(C)C=1)C(=O)N2C[C@@H1](CNC(=O)CS(=O)(=O)CCO)C(C)(C)C2 COCCN(CCNC(=O)/C=C/C1=CN=C[NH1]1)C(=O)[C@@H1]2C=CCCC2 C[C@H1](NC1=NC=NC2=NC=NC=C12)[C@H1]3CN(C(=O)C45CCC(CC4)OC5)CCO3 CN=C1[NH1]C(C(=O)N2CCC[C@@H1](NC(=O)C3=CN=C(C(F)(F)F)C(C)=C3)C2)=CS1 CN1C(=O)OC[C@H1]1C(=O)N2CCC[C@H1]2CC(=O)NCC3(N4C=CC=N4)CC3 O=C(CN1C=C(Br)C=N1)N[C@@H1]2CC[C@H1]2NC(=O)C(O)(C3CC3)C4CC4 COCCC1N(CC=2C(C(=O)O)=NOC=2)CC(C)(C)S1(=O)=O C[C@H1](CN(C)C(=O)CCN1C=CC=NC1=O)N(C)C(=O)[C@@H1]2CCOC3(CCC3)C2 O=C(N[C@@H1]1CCCN(C(=O)CC=C(Cl)Cl)CC[C@@H1]1CO)C2CC(F)(CF)C2 C/C=C/C[C@H1](CC)C(=O)N[C@](C)(CSC)C(=O)N=C1C=CN(CC2CC2)[NH1]1 CCC[C@H1](C)CC(=O)N[C@]1(C(=O)N[C@H1]2CO[C@@H1](C(C)C)C2)C[C@H1](O)C1 CC1CCC(C(=O)N2C[C@@H1](C)N(C(=O)C3=CC=CN=C3F)C[C@H1]2C)CC1 CC1=CC=CC(NC(=O)C(=O)N[C@@]2(C)CCN(C3=NC=C([N+1](=O)[O-1])C=N3)C2)=C1 COC(=CC1=CC=CC=C1)C(=O)N2CCC[C@@H1](N(CCO)C(=O)[C@H1](C)CO)C2 CCC1CC(C(=O)N[C@]2(C)CCCC[C@H1]2C(=O)NC3(CC(=O)OC)CC3)C1 CC[C@@H1](C)CCC(=O)NCC[C@@H1](NC(=O)C1=CC(O)=NC2=CC=CC=C12)C(C)C CON=CC(=O)N1C[C@@H1]2CCN(C(=O)[C@@H1](O)C3=CC(F)=CC(F)=C3)[C@@H1]2C1 CC1=CSC(NC(=O)[C@H1]2C[C@@H1]2C(=O)NC3=C(Br)C=C(Cl)C=4OC=CC3=4)=C1C#N CC1=CC=C(C(=O)N[C@@H1](C)CCN(C)C(=O)CC2=CC=CC(C(C)C)=C2)C=C1C CCC1=NC(C(=O)N[C@@H1]2CN(C(=O)CC[C@H1]3CCC(=O)N3)CC[C@H1]2O)=C(C)O1 CO[C@H1](CO)C(=O)N1C[C@H1]2CC[C@@](C(=O)NCC[C@H1]3CCCCO3)(C2)C1 C[C@@H1](CNC(=O)[C@](C)(O)C1CC1)NC(=O)C2=CC=C(C=3C=C[NH1]N=3)S2 C[C@@H1]1CN2CCN1C[C@@H1]2C(=O)N[C@@]3(C)CCN(C(=O)[C@@H1]4CC45CCCCCC5)C3 CCCOC1=CC(CNC[C@@H1]2C[C@H1](OC)O[C@@H1]2OC)=CC=N1 C=CC1(CC(=O)N[C@H1]2CC[C@H1]2N3C(=O)[C@H1](CC4=CC=C(C)C=C4)N(C)C3=O)CC1 O=C(N[C@@H1]1CCN(C(=O)CCCN2C(=O)CCC2=O)C1)[C@@H1]3CCC[C@H1]4CCCN43 C#CCOC1CN(C(=O)[C@H1](CC#C)NC(=O)[C@H1](C)S(N)(=O)=O)C1 C#C[C@H1]1CC[C@H1](C(=O)N2C[C@H1](CNC(=O)CO)C(C)(C)C2)CC1 CC(=O)N1CC[C@@H1](OCC2CCN(C(=O)C3=CN([C@@H1]4COC[C@@H1]4F)N=N3)CC2)C1 CCC1=NN(C)C=C1C(=O)NCC[C@@]23CC[C@@H1](C2)N(C(=O)[C@@H1]4CCO4)C3 CCO[C@@H1](C)C(=O)N[C@@H1]1CCN(C(=O)C2=CC(F)=CC(F)=C2)C[C@H1](O)C1 CC1=NC=C(C=CC(=O)N2CCC(NC(=O)CCCN(C)C)CC2)C(O)=N1 CS[C@H1](C)CC(=O)N1CC[C@@H1](C2(NC(=O)CC3=CC=CC(F)=C3)CC2)C1 CC1=CC(O)=CC(O)=C1CN2CC3(C[C@@H1]3C(=O)NCC4COC4)C2 CC[C@H1](CC(=O)N1CCN(C(=O)C2C3(CCC3)C24CCC4)CC[C@H1]1C)C5CC5 CC(C)N1N=CC=C1C(=O)N[C@H1]2CCOC[C@H1]2NC(=O)[C@H1]3CCCC(=O)N3 C[C@H1](CNC(=O)CNC(=O)C1=CC=CC=C1)NC(=O)C2=CC=C3C(=C2)CCCC3 CC=1C=NN(CC(=O)N2CC[C@@H1]([C@@H1](F)C(=O)N(C)C3CC3)C2)C=1 C[C@H1](C(=O)N[C@H1]1C[C@H1](CC(=O)NC(C)(C)CO)C1)C(C)(C)C CC(=O)CSCC(=O)NCCCCNC(=O)C1CC(C(F)(F)F)C1 CC1=CC=C(C(=O)N[C@@H1](CO)CNC(=O)[C@@H1](C)C2=CC=CC(O)=C2)C(C)=N1 CC1=NC=C(C(=O)N2CC(=O)NC[C@H1]2C(=O)N(C)C[C@@H1]3OCCC3(C)C)S1 CCCCC1=NC=C(C(=O)N2C[C@H1](O)[C@H1](NC(=O)[C@H1](C)CC(C)C)C2)S1 CC1(C)CCCN(C(=O)NCCC2=C[NH1]C3=CC=C(Br)C=C23)[C@H1]1CN CCC1=NC=C(C(=O)N[C@@H1](C)[C@@H1]2CCN(C(=O)CCCC=3SC=CC=3C)C2)S1 C[C@@H1](C(=O)N[C@H1]1CCCN(C(=O)C2OCCCO2)CC1)C3=C[NH1]C4=CC=CC=C34 C=C[C@H1](O)C(=O)NC[C@]1(CNC(=O)[C@]23CC=CCN2CCC3)CC1(F)F CC1=NOC(C)=C1CCC(=O)NC2(CNC(=O)[C@H1]3CC[C@H1]3C=4N=C[NH1]N=4)CCC2 C=C(C)COCC(=O)N[C@H1]1C[C@@H1](C)CN(C(=O)C23CCCN(CCC2)C3)C1 N[C@@H1](CN[C@H1]1CCC=CCCC1)C2CCCCC2 CCCOCC(=O)N1CCN(C(=O)C2(OCC)CCC2)C[C@H1](O)C1 CC(=O)N[C@@H1](C)C(=O)N1CCC[C@@](O)(CN(C)C(=O)C2=COC3=CC=CC=C23)C1 CC1=CC=C(C(C)C)C=C1C(=O)NC[C@H1]2CCN(C(=O)[C@@]3(C)CC3(C)C)C2 O=C(CC=1C=CSC=1Cl)NCC2(NC(=O)C3=COCC3)CC2 CC[C@@H1](F)C(=O)N[C@H1](CO)CNC(=O)C1=CC=C(C=2N=C[NH1]N=2)C=C1 COCC(C)(C)C(=O)NC[C@H1]1CN(C(=O)C2CC3(C2)CC3(F)F)CCN1C COC[C@]1(CNC(=O)C2=CC(C)=CO2)CCCN1C(=O)[C@H1]3CC34CCOCC4 CN1C=C(OCC(=O)N[C@@H1]2COC[C@@H1]2NC(=O)[C@@H1](F)C3CCC3)C=N1 COC(=O)[C@H1](CCSC(C)=O)NCCC1CC2(C1)C(F)(F)C23CC3 CC1=CN=C(CN(C)C(=O)C2(CC(C)(C)C)CC(F)(F)C2)[NH1]1 COC[C@@]1(C(=O)N2CC[C@@H1](NC(=O)[C@H1]3CCCCN3C)CC(C)(C)C2)C=CCC1 CN1CCCC[C@H1]1C(=O)NCCCCCCN2C=C(C3=CC=C(C#N)N=C3)N=N2 O=C(CCC1=NC=CS1)NC2=CC=CC(NC(=O)[C@H1]3CC(=O)N(C(C)(C)C)C3)=C2 CO[C@@H1]1C[C@@H1](CNC(=O)C=CC2=CC=C([N+1](=O)[O-1])C=C2)N(C(=O)C=3C=NSN=3)C1 CC1=CN=C(CCC(=O)N[C@@H1]2CCCC[C@H1]2NC(=O)CCC3CCCC3)[NH1]1 C#CC1=CC=CC(C(=O)N[C@@]23CC[C@@H1](C2)N(C(=O)CCSCCCC)C3)=C1C CCN1C=CC=C1C(=O)NCC[C@H1]2CCN(C(=O)C=3C=CN4N=CC=CC=34)C2 CC(C)[C@@H1](CCNC(=O)C1=CC=C2C=COC2=C1)NC(=O)C3=C(F)C=CC=C3Cl COC(=O)N1CC(C)(NC(=O)[C@@]2(F)CCCN(C(=O)C3=CC(OC)=NN3C)C2)C1 CC1=CC(=NC(=O)[C@]23C[C@H1]2CN(CC4=NC=C(C)S4)C3)[NH1]C(Cl)=N1 CCC1=NN=C(SCC2=CC=C(C(=O)NC)C=C2)N1CCNC(=O)OC(C)(C)C CC=1C=CC(=N)[NH1]C=1C(=O)NC[C@H1]2C[C@H1](C)N(C(=O)C[C@@H1](C)C3=CC=CC=C3)C2 CCOC=CC(=O)NC[C@@H1]1C[C@H1]2CC[C@H1]1N2C(=O)[C@H1]3CC3(Cl)Cl COCC1(COC)C[C@@H1]1C(=O)NC2=CC=CC=C2[C@H1](O)C3=CC=CC=C3 CCC=1ON=C(C)C=1S(=O)(=O)N[C@H1]2CCN(C)[C@@H1](C)C2 CCC[C@@H1](C)C(=O)N[C@H1]1CN(C(=O)C2C[C@H1]3CC[C@H1](C2)C3)CCC14CCOCC4 CN1C[C@@H1](F)C[C@H1]1C(=O)N[C@@H1]2CS(=O)(=O)C[C@H1]2NC(=O)[C@@]3(C)CCCO3 CC1=CC=C(C(F)(F)C(=O)N2CCCC[C@@H1]2C3=CC=CN=C3O)N=C1 CC1=C(C(=O)NCCN(CC(=O)N[C@H1]2CCC[C@@H1]2C(C)(C)C)C3CC3)CC1 C/C=C/C[C@H1](CC)C(=O)N[C@@H1]1C[C@@H1]C[C@H1]1N(C(=O)C2=CC=CC=C2OCC#N)C C[C@@H1](NC(=O)CC1=CC=NN1C)C2CN(C(=O)C3(C(=O)OC(C)(C)C)CC3)C2 CC1=CC(C)=NC(C(=O)N[C@H1]2C[C@H1](CNC(=O)C(C)(C)C#N)C2)=C1 COCC(=O)N[C@H1]1CN(C(=O)CS(=O)(=O)CC(C)C)C[C@H1]1N2C=CN=N2 C[C@H1](O)CN(CCO)C(=O)[C@@H1](O)C1CN(C(=O)CCC(=O)N(C)C)C1 CCOC(=O)C1(C(=O)N[C@@H1]2CC[C@H1](NC(=O)C3=N[NH1]C=C3F)C2)CC=CC1 CCOCCCCC(=O)N(CC(=O)NCC=1SN=NC=1C)CC(C)C CCCC[C@@H1](O)C(=O)NC[C@]1(F)C[C@@H1](CNC(=O)C2(CC3CC3)CCC2)C1 CCC=CC=CC(=O)N1CCN(CC(C)(C)NC(=O)[C@H1](COC)C(F)(F)F)CC1 CCCC1(C(=O)N2CCN(C(=O)CC=3C=CON=3)C[C@@H1]2CC)CC1 O=C(NCC=CCl)[C@@H1]1[C@H1]2CC[C@H1](C2)N1C(=O)C=3C=NN4C=3OCC4 CCN(C)C(=O)C(=O)N1CC(O)(C2=CC=CC(F)=C2)C1 CCC1=C(C(=O)N2CC[C@@H1](C(=O)N(C)CCC(C)(C)C)C23CCC3)C=NN1C C=CCC1(NC(=O)CC(=O)NC)CCN(C(=O)[C@H1]2CC[C@H1]3CCC(=O)N32)CC1 C[C@@H1]1OCC[C@@H1]1C(=O)NC[C@H1](NC(=O)COC2CCCC2)C3=CC=CC=C3 C=CC[C@H1](CC(=O)NC[C@](C)(CC)CO)NC(=O)C1=CC=C(C#N)O1 C[C@H1](NC(=O)C1=CN=NN1C2CC2)C3=NOC=C3C(=O)N(CCCO)C4CC4 C[C@H1](NC(=O)CC1=CCCC1)[C@@H1](CO)NC(=O)C2=CN=CO2 CC1(C)CN(C(=O)C2CCOCC2)CC[C@@H1]1NC(=O)CCCC3=NC=CO3 CCN1N=CC([N+1](=O)[O-1])=C1C(=O)NC2CCCN(C(=O)C(C)(C)COC)CCC2 O=C(CC1=CSC(C2=NC=CC=N2)=N1)NCC#CCNC(=O)[C@H1]3CCCSC3 CC[C@@H1]1CN(C(=O)CCC(=O)N(C)C)CCN1C(=O)[C@@H1]2CCCC3=CC=CN=C32 CCC1=NOC(CCC(=O)NCC2(O)CCN(C(=O)CCC=3C=CON=3)CC2)=N1 CC[C@H1]1CN(C(=O)C2=CC=C(C#N)C(C)=C2)C[C@@H1]1C(=O)N[C@H1]3CCCC(F)(F)C3 CC[C@@H1]1CN(C(=O)C2=CC=NC(F)=C2OC)CC[C@H1]1NC(=O)CN(C)C(N)=O COCC1(C(=O)N2CCO[C@H1](C)CC2)CN(C(=O)COCC(=O)OC)C1 C#CCOCC(=O)N[C@@H1]1C[C@H1](C)CN(C(=O)CC23COC(CF)(C2)C3)C1 CC=1C=COC=1C(=O)N[C@@H1]2CC[C@H1]2CNC(=O)[C@@H1]3CC(C(F)(F)F)=NO3 C[C@@H1]1CC[C@@H1]1C(=O)NCCNC(=O)C2=C[NH1]C3=CC=CN=C3C2=O CC1=NN=C2C=CC(C(=O)N3C[C@H1](C)C(NC(=O)CC(C)(C)O)[C@@H1](C)C3)=CN12 CC1=CC=C(CC(=O)NC[C@H1]2CCN(C(=O)[C@@H1](C)C#N)C23CC3)C(Br)=C1 COC[C@H1]1CN(C(=O)C=CC2=C(F)C=CC=C2F)CCN1C(=O)C=3N=NSC=3C CCN1C=NC2=C(N(C)C[C@](C)(CC)OC)N=C(N3CC[C@@H1](P(C)(C)=O)C3)N=C21 CC(C)C1=CC(=NC(=O)[C@H1]2[C@H1]3CC[C@H1](C3)CN2C(=O)OC(C)(C)C)[NH1][NH1]1 CO[C@@H1](CC1CC1)C(=O)N2CCN(C(=O)C=3OC=NC=3C)[C@H1](C4=CC=CC=N4)C2 O=C(N[C@]12CN(C(=O)C[C@H1]3CCCC[C@@H1]3O)C[C@@H1]1CS(=O)(=O)C2)C4=COCCO4 CCSC1(C(=O)N[C@@H1]2C[C@H1]3C[C@@H1](NC(=O)[C@H1]4C[C@@H1](C)CC(C)(C)C4)[C@H1]3C2)CC1 CCCC1=CC=CC(C(=O)N[C@@H1]2CN(C(=O)CC3=CC(C)=NS3)CC24CC4)=C1 CO[C@@H1](CNC(=O)C1=CC=NC=C1F)CN2C=C(C3=CC=C(C)C(C#N)=C3)N=N2 C[C@@H1](CNC(=O)CCOC1=CC=CC=C1)CN(C)C(=O)C2=NC=CC=C2N(C)C CC(C)(C)N1C=NC(C(=O)N[C@@H1]2CCN(CCCNC(=O)CC=3C=N[NH1]C=3)C2)=C1 C=CCCN1C=C(C(=O)N2C[C@@H1](C)[C@@H1](NC(=O)[C@@H1]3CCCC3(F)F)C2)N=N1 O=C(C[C@@H1](O)C1CC1)N2CCC[C@H1]([C@@H1]3CCN(C(=O)C4=CC=C(C(F)(F)F)O4)C3)C2 CO[C@@H1](CNC(=O)[C@@H1]1CC1(F)F)C(=O)NC2=CC=C3C=CC=CC3=C2 O=C(CC1=COC=N1)N[C@H1]2C[C@H1](CNC(=O)C3=CC4C=C(Br)CC=C4C3=O)C2 CN(CC1CCCO1)C(=O)C2=CC=CC=C2CO C[C@H1](CCCC(=O)N[C@@H1]1CCN(C)C1)NC(=O)C[C@@H1]2CCC[C@@H1]3C[C@H1]23 CSC[C@H1](C)C(=O)N1C[C@@H1](C)[C@H1](CNC(=O)[C@@H1]2C[C@H1]3CC[C@H1]2O3)C1 CC1=NC=C(CNC(=O)C2=CC[C@H1](NC(=O)C3=N[NH1]C(C)=C3C)C2)[NH1]1 CN(C)C[C@@]1(C)CCN(C(=O)[C@@]23C[C@@H1](CO2)N(C(=O)C4=CN=C(O)O4)C3)C1 CCN1CCN(C2=CC=C(C(=O)N3C[C@H1](C4CC4)C[C@@H1]3C)C=C2F)CC1 C=CC[C@@H1](CC(C)C)C(=O)NC1([C@@H1]2CCCN(C(=O)C3=NSC=C3N)C2)CC1 CC(C)CN=C(NCC1=NC=C[NH1]C1=O)N(C)CC[C@H1]2CCCN2C CN(C)NC(=O)CCC(=O)N1C[C@H1](N(C)C(=O)[C@H1]2CC23CCC3)C4(CC4)C1 CO[C@H1]1CN(C(=O)CCC=2C=CN(C)N=2)C[C@@H1]1C(=O)NCC3[C@H1]4CCC[C@H1]34 C[C@@H1]1CN(C(=O)C2=NC(=O)N(C)[NH1]2)C[C@H1]1NC(=O)[C@H1]3CC[C@H1]3C4=NN=C(S)N4C CC1=NC=CC=C1CC(=O)N[C@@]2(C)CCCC[C@H1]2C(=O)N3[C@H1]4COC[C@H1]3C4 C[C@H1](CC1CN(C(=O)C2(O)COC2)C1)NC(=O)CSCC3=CC=NC=C3 CCC1=NC(C(=O)NC[C@H1]2C[C@@H1](N=C3N=C[NH1]S3)CC2)=CS1 CN1N=C(C(=O)NC2CCC(O)(CNC(=O)[C@@]34COC[C@@H1]3C4)CC2)C=C1C(N)=O O=C(C1=C2C=C(Br)C=CC2=NN1O)N3CCCN(CC4=CC=CC=N4)CC3 O=C(CN1C(=O)CNC1=O)N2CCC3(CC2)CCN(C(=O)CC=4C=N[NH1]C=4)CC3 CC1(C)C[C@@H1]1C(=O)N[C@]2(CO)CCN(C(=O)COCC(F)(F)F)C2 CN(C)CC1=CC(C(=O)NC2CCC(N(C)C(=O)[C@@H1](O)CC3CC3)CC2)=NO1 CC[C@@H1](C)/C=C/C(=O)NC[C@@H1]1[C@H1]2CC[C@H1](C2)N1C(=O)C3=C(F)C(C)=CC(N)=C3F CC[C@H1](C(=O)NC[C@H1](C)CC(=O)N1CCOC[C@@H1]1C(F)F)N2C=NC=N2 CC1=CC(C(=O)N2C[C@H1]3CC[C@H1]2[C@H1](CNC(=O)/C(F)=C/CCF)C3)=NO1 F[C@H1]1CCCC[C@@H1]1N[C@H1](C2=CC(Cl)=NC(Cl)=C2F)C3=NN=NN3C4CCC4 CC[C@@H1](CNC(=O)[C@H1](N1CCNC1=O)C(C)(C)C)NC(=O)C2=CC(O)=NN2C CO[C@]1(C(=O)N[C@H1](CC(=O)NOC2CCC2)C3CC3)CCCOC1 CC=1N=C(C(C)(C)C)SC=1C(=O)NC[C@H1](O)CNC(=O)CC(F)(F)F CCC=1C=C(C(=O)N[C@H1]2[C@H1]3C[C@@H1]4[C@H1]2[C@@H1]4[C@@H1]3C(=O)N[C@H1]5CCCN6CCC[C@H1]56)ON=1 CN(C(=O)[C@@H1]1C[C@@]12CCN(C(=O)C3=CCCC3)C2)[C@@H1]4C[C@H1]4C5CC5 O=C(NCCO[C@H1]1CCN(C(=O)C2=CC=C(F)S2)C1)[C@H1]3CCCC[C@H1]3C4CC4 CC[C@H1](C)[C@H1](C(=O)N[C@@H1]1C[C@H1]2C[C@H1](O)[C@@H1]1C2)N(C)C(=O)[C@H1](C)C(C)(C)C C=CCOCC(=O)N1CC[C@@H1](NC(=O)[C@H1]2CCC3=CC(OC)=CC=C3C2)C1(C)C CC(=O)OCCCC(=O)N1CC2(CN(C(=O)CN3C=CC=CC3=O)C[C@@H1]2CO)C1 COC1=CN=C(F)C=C1C2=CC=C3C=NC(NC(=O)C4=CC=C(F)C=C4I)=NC3=C2 N#CC1=CC=C(Cl)C=C1S(=O)(=O)NC[C@@]2(O)CCC3=CC=CC=C32 CC1=CC=C(CC(=O)NCC2(CCN2C(=O)[C@@H1]3C[C@H1]3C(C)(C)C)C)C(C)=C1 C=CCC1(NC(=O)[C@H1]2C[C@@]2(CC)C(C)C)CN(C(=O)CC3=CC=CN=C3Cl)C1 CCCNC(=O)CCCC(=O)N1CCC[C@H1]1C2(NC(=O)CN3C=NN=C3)CC2 CN1C=C(C=CC(=O)N2CCC(CO)(CNC(=O)C[C@H1]3CCCOC3)CC2)C=N1 CC[C@@H1](C)[C@@H1](C(=O)NC=1C=CC2=N[NH1]C=C2C=1)N(C)C(=O)C(=O)NOC CC(C(=O)N[C@@H1]1CCC[C@H1](N(C)C(=O)C=CCN2C=NC=N2)C1)=C3CCCC3 C=CC[C@H1](OC)C(=O)N1CCCCCC[C@@H1]1C(=O)NCC2C[C@H1]3CCC[C@@H1]3C2 CCC1=NC(C)=C(C(=O)N[C@@H1]2CN(C(=O)[C@H1]3CCC(C)(C)O3)CC4(CC4)C2)O1 CC(C)(C#N)CCC(=O)NC[C@](C)(NC(=O)[C@@H1]1CCCN(C(C)C)C1)C2CC2 CC1=NC(CC(=O)N[C@H1]2CC[C@H1](NC(=O)C=3C=CC(=O)N(O)C=3)CC2C)=N[NH1]1 C#CCOCCC(=O)N[C@H1]1COC2(CNC(=O)C3CC4(CC[C@@H1]4OC)C3)CC1C2 CNC(=O)C(C)(C)C(=O)N1CC[C@@](CO)(CNC(=O)C=2C=NN(C3CC3)C=2)C1 CC1=CC(F)=C(N)C(C(=O)N2CCN(C(=O)C=3ON=CC=3C)[C@H1]4C[C@H1]42)=C1 CS[C@@H1]1CN(C(=O)C2=CC=C(C)O2)C[C@H1]1NC(=O)[C@H1]3CCC4=NC(C)=CN4C3 CC=1C=CN2N=CC(C(=O)NC[C@@]3(O)CCN(C(=O)[C@@]4(C)CC4(F)F)C3)=C2C=1 CCO[C@@H1](C)CCC(=O)N1C[C@@H1](F)C[C@@H1]1CNC(=O)C2=COC(C)=N2 CN1C(C(=O)N[C@@H1]2C[C@H1]2CNC(=O)CC=3C=CON=3)=CC(Cl)=C1Cl CC1(C)[C@@H1](C(=O)N2C[C@H1](C)[C@@H1](CO)C2)[C@H1]1CNC(=O)C=CC3=CC=NC=N3 CCCC[C@H1](C(=O)NC[C@@H1]1C[C@H1](F)CN1C(=O)[C@@H1](C)SC(F)(F)F)C(C)C CCOC1(CC(=O)NCCCN(CC)C(=O)[C@@H1]2CC(=O)N(C(C)C)C2)CCC1 CCOC=1C=C(C(=O)N2C[C@H1]3CC(NC(=O)C(C)(C)C(C)(F)F)CC[C@H1]3C2)ON=1 C[C@@H1](CN(C)C(=O)CCCCC#N)N(C)C(=O)C[C@H1]1OCCC=2SC=CC=21 CC[C@@H1](C)CCCC(=O)N1CCCC[C@H1](NC(=O)CCCC(C)(C)CC)CC1 CN1C=C(C(=O)N2CCC[C@@H1]3CCN(C(=O)C(C)(C)S(C)(=O)=O)C[C@@H1]32)C(O)=N1 O=C1CN(CCNC(=O)[C@@H1]2CCCCCN2C(=O)C3=CC=NC(O)=C3)CCN1 CCC1(C(=O)N[C@@H1]2C[C@@H1](C)CN(C(=O)CC3CCN(C(C)C)CC3)C2)CC1 CC(C)=C(Br)C(=O)NC[C@H1](C)CNC(=O)CCCC[C@@H1]1SC[C@@H1]2NC(=O)N[C@H1]12 CC[C@H1](COC)C(=O)N[C@@H1]1CCN(C(=O)C=2SC=CC=2Br)C[C@H1]1CC COC(C)(C)C(=O)N[C@H1]1CC[C@@H1](C(=O)NC[C@H1](O)[C@H1]2CCCO2)C1 CSCC1(CC(=O)N2CCO[C@@H1](C(=O)NC=3C=CSC=3C)C2)CC1 COCCC1=CC(C(=O)N(C)CC(C)(C)NC(=O)C2=CC(N)=NC(Cl)=C2)=NO1 CC1(C)C[C@@H1](NC(=O)CC2=CC=C(Br)C=C2F)CN1C(=O)[C@@H1]3C[C@@H1]4C[C@@H1]4C3 C#CC1=CC=C(C(=O)N2C[C@@H1](C)[C@H1](CNC(=O)CCC3=NC(C)=CS3)C2)C=C1 C=CCC[C@@H1]1CCCN1C(=O)[C@@H1](CCC)NC(=O)CCNC(=O)COC CCN(CCNC(=O)C1CC2(CC(O)C2)C1)C(=O)CC3=CC(C)=CS3 O=C(CCC1CCC1)N2CCCN(C(=O)C3=CN=C(O)S3)CC2 CN1C(S)=NN=C1CN=C2[NH1]C(=N[C@H1]3C[C@H1](CO)C3)C4=NC=CC=C4[NH1]2 NS(=O)(=O)C1=CC(Cl)=C(F)C(C(=O)N[C@@H1]2CCC[C@@H1]2CNC(=O)/C(Cl)=C/Cl)=C1 C=CC[C@H1](CNC(=O)[C@@H1]1O[C@H1]2CC[C@H1]1C2)NC(=O)C3=CC(C)=C(C)C=C3C CC(C)[C@H1](O)[C@H1](C)C(=O)N1CC2(CC2)C[C@H1]1CC(=O)NC[C@](C)(O)CO CN(C[C@@]1(O)CCCN(C(=O)CC2=NN=C(O)S2)CC1)C(=O)C[C@H1]3CNC(=O)C3 CC=1C=C2N=CC(C(=O)N3CC=C[C@@H1]3CNC(=O)[C@@H1](CC)CC(F)F)=C(C)N2N=1 C[C@@H1](NCCC1CC(CO)C1)C2=CC=C(C3=CN=CN=C3)C=C2 CCC1=CN2C(C(=O)NC[C@]3(C)CCCN3C(=O)CCOC4CC4)=CC=CC2=N1 CC1=CC(=NCCCN2CCC2)[NH1]C(N[C@H1]3CC[C@@H1](C(=O)OC(C)(C)C)C3)=N1 C[C@H1](C(=O)N[C@@H1]1CCN(C(=O)[C@@H1]2CCC3=N[NH1]C=C3C2)C1(C)C)N4CCCCC4 COC1=CC(Br)=C(N)C(C(=O)O[C@H1](C)C2=NOC(C)=N2)=C1 CCC1=CC=C2N=CC=CC2=C1NC(=O)CC[C@@](C)(O)C3=CC=CC=C3 CC1(CNC(=O)[C@@H1]2CCC[C@H1](C#N)C2)CCN(C(=O)[C@H1](O)C3CCCCC3)CC1 O=C(CC1=CN=CS1)NC[C@H1]2CC[C@@H1](C(=O)N[C@H1]3CCN4C=NN=C4C3)O2 CSC1=CN=C([C@H1](C(=O)NC2=C(C)C=CC=C2C)N3CCN4N=CC(C)=C4C3)S1 CC1=N[NH1]C=C1CC(=O)N[C@H1](C)C(C)(C)C(=O)NC[C@@]2(C)CC=CCC2 CCO[C@H1](C(=O)NCC1(NC(=O)/C=C/C=C/C2=CC=CC=C2)CCC1)C3CC3 C[C@H1](NC(=O)C[C@@H1]1CC=CCC1)C(=O)NCCCN2CCC2 CC(C)(O)C(=O)NC[C@@H1](NC(=O)C(F)(F)C1=CC=C(Cl)C=C1)[C@H1]2CCOC2 CC[C@H1](CC1=CC=C(C(F)(F)F)C=C1)C(=O)N(C)CCCNC(=O)C[C@@H1](C)F CC1=CSC(C(=O)NC[C@@H1]2CCCN2C3=CC(C(C)C)=NC(N4CCCC4)=N3)=C1 CCOCCN1N=NN=C1[C@@](C)(NCC2=CC=CC(C(C)(F)F)=C2)[C@H1]3CCOC3 CCCC=1C=C(C(=O)N2C[C@H1]3CCC[C@H1]2[C@@H1]3CNC(=O)[C@H1]4CC[C@@H1](C)C4)N(C)N=1 C[C@H1](O)C1CCN(C(=O)C=2C=COC=2CNC(=O)[C@H1]3C[C@]3(F)Cl)CC1 CC1=NC(C)=C(C(=O)N2CC[C@@H1](C(=O)N3CC[C@@]4(CNC(=O)C4)C3)C25CCC5)O1 CCC=CC(=O)NCC1=NOC=C1C(=O)N(C)C[C@H1](C)C(=O)OC CN1CC[C@H1](NC(=O)C2=CN=C[NH1]2)[C@]13CCCN(C(=O)[C@@]4(C)CCNC(=O)C4)C3 CC(C)(O)CC(=O)N[C@H1]1C[C@@H1]2CC[C@H1](C1)N2C(=O)C3=CC=C4N=CC=CC4=C3Cl COCC1CN(C(=O)C(=O)NCC(F)(F)F)CCO1 O=C(N[C@@H1]1CN(C(=O)CCC2CCCC2)C[C@@H1]1O)C3=COC=C3Br CC[C@H1](CO)NC(=O)C[C@H1]1CCN(C(=O)[C@@H1](N)C2=CC=CC(C)=C2)C1 C[C@H1](C(=O)N[C@H1](C(=O)NC(C)(C)CCCO)C=1C=COC=1)C2CCOCC2 OCCOC1=C(Cl)C=C(NCCCC[C@@H1]2CCC[C@H1]2O)C(F)=C1Br C=C[C@H1](C)CC(=O)NC1CC(NC(=O)C2=CC=C(Br)C(C)=C2OC)C1 CC1=CC=C(C)C(C(=O)NC[C@H1](CNC(=O)C2=N[NH1]C(O)=N2)C(F)(F)F)=C1 CSC1=CC=C(O)C(C(=O)N[C@H1](C)[C@H1]2CCCCN2C(=O)C=CC3=CSC=N3)=C1 CCCC=C[C@@H1](O)C(=O)NCC#CCNC(=O)[C@H1](C)N(C)C(=O)OC(C)(C)C CO[C@@H1]1CCC12CC(C(=O)N[C@@H1]3CN(C(=O)C4=CC=CN4C)C[C@@H1]3N5C=CN=N5)C2 CC1(C)[C@@H1](C(=O)N=C2C=C(C3CCC3)[NH1][NH1]2)C1(F)F CC(C)CCSCC(=O)N[C@@H1]1CN(C(=O)C[C@H1]2CCCSC2)C(C)(C)C1 CC(C)=CCCC(=O)N1CC(C)(C)C[C@H1]1CNC(=O)C=2C=C(C(C)C)[NH1]N=2 C#CC[C@H1](C)C(=O)N1C[C@H1](CNC(=O)C(F)(F)C2=NC=CN2C)OC(C)(C)C1 CCC[C@@H1]1CCCN1C(=O)[C@]2(NC(=O)C[C@@H1](O)[C@H1](C)CC)CCN(C)C2 C[C@@H1](CC(=O)N1CCOC[C@H1]1CN(C)C(=O)CC2(C)CC(F)(F)C2)CC(F)(F)F CC1(C)OC[C@H1]2C[C@]21C(=O)N[C@H1]3C[C@@H1](CO)N(C(=O)CN4C=CC=NC4=O)C3 COC1=CC=CC([C@H1](O)C(=O)N[C@@H1]2CCCC[C@H1]2NC(=O)C=3C=C(C)N(C)N=3)=C1 C[C@@H1](CNC(=O)C1=CC=CC(N2C=NC=N2)=C1)N(C)C(=O)C[C@@H1](C)[C@H1]3CCCO3 CCC1=C[NH1]N=C1C(=O)NC[C@H1](NC(=O)C2(C)CCCC2)C3CC3 CC1=C(C(=O)N[C@@H1](COC(=N)O)C(=O)O)N=NN1C2=CC=CC(Cl)=C2 C=CC[C@@H1](C(=O)N[C@@H1]1CC[C@H1]1CNC(=O)C=2C=C(Br)C3=NC=CN3C=2)C(C)C C=C(Cl)CCC(=O)NC(C)(C)[C@H1]1CCN(C(=O)C=2SC=CC=2CC)C1 CCC1=CC=CC=C1NC(=O)[C@H1]([C@@H1]2C[C@]2(C)Br)N3CCS[C@@H1](CC)C3 CCC1=CC=C([C@@H1](NC2CC3=CSC=C3C2)C4=NN=NN4[C@H1](C)CC)C(OC)=C1 C[C@H1](CNC(=O)CCN1CC[C@H1](F)C1)CNC(=O)CCCC(F)F COC(=O)C1=CC=CC(CN2CC[C@@]3(C[C@H1]3C(=O)N(C)CC4=CC=CC=C4Cl)C2)=N1 CC(C)N1CCC(CC(=O)N[C@@]23CCN(C(=O)C4=CCCCO4)C[C@@H1]2C3)CC1 CC(C)[C@H1](CNC(=O)[C@]1(C)C[C@]1(F)Cl)NC(=O)C2=C[NH1]C(=N)N=C2O C[C@@H1](CC=1C=NN(C)C=1)C(=O)N2CCC(CN(C)CCCC3CCCCC3)CC2 COCCSCC(=O)NC[C@@H1](NC(=O)C=1OC=CC=1Cl)C2=CC=CC=C2 CN(CC1CCOCC1)C(=O)CC2(N)CCN(C(=O)OC(C)(C)C)CC2 C=CCOCCCC(=O)N1CCN(C(=O)C2=CS(=O)CCO2)[C@H1](CC(F)F)C1 C[C@H1](CCNC(=O)[C@@](C)(O)C(F)(F)F)N(C)C(=O)CCCN1C=CN=C1 CC1=CC(CN)=CC(S(=O)(=O)N2CCN3C=NN=C3C2)=C1 CN1C[C@@H1]2C[C@H1]1CN2C(=O)C[C@H1](O)CNC(=O)[C@H1]3OCCCC3(C)C CCN(C(=O)C=C(C)Cl)C1CCN(C(=O)[C@H1]2CC23CCSCC3)CC1 CC1=CN=CN=C1NC2CC(CNC(=O)CC3C[C@@H1]4CC[C@H1](C3)N4C)C2 CCO[C@@H1](C)C(=O)N1CC(C)(C(F)(F)F)C1 C[C@@H1](OC1=CC(Cl)=CC(Cl)=C1)C(=O)N2CC3(CC(S(C)(=O)=O)C3)C2 CCO[C@H1](C)C1=CN(CC2=CC=CC(C(=O)N(C)C3=C(C)C=CC=C3C)=C2)N=N1 CC1=CC=C2C(=C1)C[C@H1](C(=O)NC3=CSC4=NC=CC=C34)CO2 CCCN1CCC[C@H1]1C(=O)NC[C@@H1](NC(=O)C=2C=N[NH1]C=2)C3=CC=CC(OC)=C3 O=C(N[C@@H1]1CC[C@]2(CCCN(C(=O)C3=CC(Cl)=NS3)C2)C1)C4=NC=CC(Cl)=C4O CCN(CC=1C=COC=1)C(=O)[C@H1]2CCN(C(=O)C=CCOC)[C@H1]2C CN1N=C(C(=O)N2CC(N3C[C@@H1](NC(=O)C4=CN=NS4)CC3=O)C2)C=CC1=O C[C@@H1](CCN(C)C(=O)C1=NOC=C1C(C)(C)C)NC(=O)CNC(=O)CC(C)(C)C O=C(COC=1C=CSN=1)NC[C@H1]2CC[C@H1](NC(=O)C3=NC=CC4=NC=CC=C34)C2 CC1=C(Br)C(CNC(=O)C(=O)N[C@H1]2CC[C@@H1](C(=O)O)C2)=NN1C CC1=CC(Cl)=C(CNC(=O)C(=O)N[C@H1]2CC[C@@H1](CC3=CC=CC=C3)C2=O)C(Cl)=C1 CC=1N=COC=1C(=O)N2CCO[C@H1]([C@H1](C)NC(=O)[C@@]34CCCC[C@@H1]3C4)C2 C[C@@H1](CC1=CC=C2C(=C1)OCO2)NC(=O)NC3=CC(C4=CC=CC=C4)=NN3C CCC(=O)N1CCC[C@H1]2CCN(C(=O)C3=CC=C(C4(C(F)(F)F)N=N4)O3)C[C@@H1]21 CCC(CC)(CO)C(=O)N1CCCC[C@@H1]1CNC(=O)C2=CN=CN2C CCCN(CCNC(=O)C1=CC(C)=C(F)C=N1)C(=O)C2=CC=C(C)C(C)=C2N O=C(C1=CN=C(C2CCC2)S1)NC34CC(F)(C3)C4 CCC1=NO[C@@H1](CC(=O)NC(C)(C)[C@H1]2CCCN2C(=O)CCOC3COC3)C1 CC(=O)N(C)CCCCC(=O)N1C[C@@H1](NC(=O)C2=C(Cl)CCC2)C[C@@H1](O)C1 COCC1(CNC(=O)C[C@@H1](C)SC)CCN(C(=O)[C@@H1]2CCC[C@H1]2P(C)(C)=O)CC1 CCC1=CC=C(C(=O)NC[C@@H1](C)CNC(=O)[C@H1]2CCS(=O)(=O)[C@H1](C)C2)C=C1CF O=C(CN1CCSCC1)NC/C=C/CC(=O)NCC[C@@]2(O)CCOC2 O=C(NC[C@]12CC[C@H1]1CN(C(=O)[C@]3(CO)CC3(F)F)C2)C4(O)CCSCC4 NS(=O)(=O)C1(C(=O)NCC2(CCNC(=O)CN3C[C@@H1]4C[C@H1]4C3)CC2)CCC1 C=CC[C@@H1](C)C(=O)N1CCCN(C(=O)CNC(=O)C2=CC=CC(C)=C2)[C@@H1](CO)C1 O=C(C[C@H1]1CCCN(C(=O)[C@@H1]2CC2(F)F)C1)N[C@H1]3C[C@H1](O)[C@H1]3O CC(C)(CS(C)(=O)=O)C(=O)N1CCC2(CC1)C[C@@H1]2CNC(=O)C3(C)CC3 CS(=O)(=O)N1CC(NC(=O)[C@@H1]2CC[C@H1](NC(=O)C3=NC=C(Cl)S3)C2)C1 CCS(=O)(=O)N(C)C1=CC=C(N[C@H1](C2=NC=CC=C2C)C3=NN=NN3CCCF)C=C1 CC=1C=COC=1C(=O)N[C@H1](C)C[C@@H1](C)NC(=O)[C@H1]2CCON2C(=O)OC(C)(C)C CC(=O)N[C@@H1]1CCN(C(=O)N[C@H1](C)C2=CC=CC=C2Cl)C1 CCN1C=NC(C(=O)N[C@H1]2C[C@H1]3C[C@@H1](NC(=O)C[C@@H1]4CCS(=O)(=O)C4)[C@@H1]2C3)=N1 C[C@@H1]1CCN(C(=O)[C@H1](O)C2CCCC2)[C@@H1]1C(=O)N3CC[C@H1](C(C)(C)C)C3 CC1=CC(=NC(=O)C(=O)N(C)[C@@H1](C)CNC(=O)CSCC2=CC=CS2)[NH1]O1 CN1C=C(C(=O)NCC[C@H1](O)CNC(=O)CCCCC(N)=O)C(=O)N(C)C1=O CN1N=CC=C1[C@H1]2CN(C(=O)[C@H1]3CSCCS3)CCN2C(=O)CCS(C)(=O)=O CC1=CC(C(=O)NCC=2C=NN(C)C=2C(=O)NCCC3=CC=CS3)=CC(C)=N1 CC[C@H1]1CC[C@H1](C(=O)N(CCNC(=O)C(C)(C)N2CCOCC2)CCOC)CC1 CC=1C=CSC=1CC(=O)NCCCOCCCNC(=O)[C@@H1](CC(F)F)C2CCC2 CSC1=CC(C(=O)N[C@H1]2C[C@H1](CNC(=O)[C@H1]3CCN3S(C)(=O)=O)C2)=CC=C1F CC1=CC(C)=NC(NS(=O)(=O)C2=CC=C(C)C=C2C(=O)OC(C)(C)C)=N1 CC(C)N1C=NC=C1C(=O)N2CCO[C@@H1](C(=O)N[C@@H1]3CCCCC[C@H1]3O)CC2 O=C(N[C@@H1]1CCCC12CN(C(=O)CC3COCCOC3)C2)C4=CC(Cl)=NC=C4F CC(C)C1=NN=C(CCC(=O)N[C@@H1]2CN(C(=O)C(=O)C3CCCC3)CC2(C)C)O1 CCOC(=O)C1(C(=O)N[C@H1](C)CN(C)C(=O)C2CCC(C(F)F)CC2)CC=CC1 CCC1=CC=C(O)C(C(=O)N(C)C2CC(NC(=O)[C@@H1]3CO[C@@H1]4CCCC[C@H1]34)C2)=C1 CCOC(=O)[C@@H1](C)[C@H1]1CCCN(C(=O)C2=N[NH1]C3=C2CCNC[C@@H1]3C)C1 CC1=CC([C@H1](C)N=C2[NH1]C(=N[C@H1]3C[C@H1](S(C)(=O)=O)C3)C=4[NH1]C=CC=4[NH1]2)=CC=C1F CC1=CC=CC(Cl)=C1OCC(=O)NCC2(F)CCN(C(=O)[C@@H1]3CCCSC3)CC2 O=C(NC[C@@H1]C1N(C(=O)C2C3(CC3)C24CC4)C[C@H1]C(F)(F)F)O1 CCCC[C@@](C)(F)C(=O)N(C)CCCC(=O)N[C@@H1]1CCN(CC)C1 C[C@H1]1C[C@@H1](CNC(=O)CN2C=CC3=CC=CC=C32)CN1C(=O)CCCF CCOC(=O)[C@H1]1C[C@@H1]1C(=O)N2CC[C@](F)(C(=O)N[C@H1]3CN(C)C4(CCC4)C3)C2 CS(=O)(=O)[C@H1]1C[C@H1](C(=O)N[C@H1]2CC[C@@H1](NC(=O)[C@@H1]3CCNC(=O)C3)C2)C1 O=C(CC[C@@H1]1NC(=O)NC1=O)NC[C@H1]2CCCN(C(=O)C3(F)CCOCC3)CC2 CC[C@H1](CSC1=CC=CC=C1)NC(=O)C(=O)N[C@@H1]2CC[C@]3(C2)CC3(F)F COCCCC(=O)N[C@]1(COC)CCCN(C(=O)C2=NC(C)=CC=C2O)C1 CC1=CC(Cl)=C(C(=O)N[C@@H1]2CN(C(=O)[C@@H1](O)CN3C=NC=N3)CC[C@H1]2O)C=C1N O=C(C[C@@H1]1CCCC12CC2)N3C[C@@H1](CO)C4(C3)CN(C(=O)C5=CN=NS5)C4 CC1=NC(CC(=O)N[C@@H1]2C[C@@H1]3CC[C@H1](C2)N3C(=O)C[C@@H1]4CCC[C@@H1]4C)=N[NH1]1 CC=C(F)C(=O)N[C@@H1]1CCCC[C@@H1]1CNC(=O)/C=C/C2=CC=C(C(=O)OC)N=C2 CCOCCCCC(=O)N1C[C@H1]2CC[C@H1]1CN(C(=O)C3=NC=CN4C=CN=C34)C2 O=C(CCC1=NN=C(O)N=C1O)N2CCN(C(=O)CCC3CCCC3)[C@H1](CO)C2 O=C(N[C@H1]1CN(CC=2C=C[NH1]C=2)CCC1(F)F)C3=CN=C(O)C=C3O NC(=O)C1=CC=C([N+1](=O)[O-1])C(S(=O)(=O)N[C@H1](CO)C2CCOCC2)=C1 CC1=CC=C(F)C=C1C(=O)C(=O)NCC[C@@H1]2CCN(C(=O)C=CC3=CSC=N3)C2 CC1(C)CN(C(=O)C2=COCC2)C[C@@H1](CNC(=O)CCN3C=NN=N3)O1 C[C@@H1]1C[C@@H1](CNC(=NCCC2=CC=CN=C2)NC3CCOCC3)CO1 CC1=CC=CC(NC(=O)NC2CCN(C(=O)C3=CC=CC=4N=C(Cl)SC3=4)CC2)=C1 CC=1N=C(CC(C)C)OC=1C(=O)N(C)C[C@@H1](C)NC(=O)C2OCCO2 CC1=CC(C)=C(C(=O)N[C@@H1]2CN(C(=O)[C@]3(O)CCOC3)C[C@@H1]2C)C(C)=N1 C[C@H1](CCNC(=O)[C@]1(C)CCNC1=O)NC(=O)CC[C@@H1]2CCOC2 CCC(CC)(CNC(=O)[C@H1]1CN(C(=O)[C@@H1](C)C#N)CCC1(C)C)OC CO[C@@H1]1C[C@@H1](CC(=O)N(C)C[C@@H1]2CCCN2C(=O)CC(F)(F)C(F)(F)F)C1(C)C CC=1SC(O)=NC=1C(=O)NC[C@@H1]2[C@H1]3C[C@H1]3CN2C(=O)CCN=C4C=CC(Cl)=N[NH1]4 CC1=CC=C2OC=C(C(=O)N3CCO[C@@H1](CNC(=O)[C@@H1]4C5C[C@@H1]6C4[C@@H1]6C5)C3)C2=C1 C#CC[C@@H1](O)C(=O)N1CCN(C(=O)C2=NC(Cl)=CC=C2Cl)C[C@H1]1C COCC1(C(=O)NC2CCN(C(N)=O)CC2)CN(C(=O)[C@H1](C)C3CCCCC3)C1 O=C(N[C@H1]1C[C@@H1](F)CN(C(=O)C2=CN3C=CN=C3S2)C1)[C@@H1]4CCN5N=NN=C5C4 COC(OC)C(=O)NC12CC(C(=O)N[C@H1](C)C3=CC=CC=C3F)(C1)C2 CCOCC1(C(=O)NC2(C3=CC=C(C(F)(F)F)C=C3)CCC2)CCC1 C#CCNC(=O)NCCCC(=O)NCC1(CNC(=O)C2=CCOCC2)CCCC1 C[C@@H1]1C(=O)N(CC(=O)N2C[C@@H1]3CCC[C@H1](C2)N3C(=O)/C(Cl)=C/Cl)C(=O)[C@@H1]1C O=C(NCC1=CC=CC=C1CNC(=O)C2=COC3=CC=CC=C23)C4=CC(O)=CS4 CC#CCN(C1CCCC1)[C@@H1](C(=O)N[C@@H1]2CCOC2)C=3C=NN(C4CCC4)C=3C C[C@@H1]1CN(C(=O)C2=CC(F)=CC(C(F)F)=C2)CCN1C(=O)[C@@H1]3CC=CCO3 COC(=O)C1(C(=O)N[C@H1]2CN(C(=O)[C@@H1](C)C3CC3)CC24CCS(=O)(=O)CC4)CC1 C=CCO[C@@H1](C)C(=O)N1[C@H1]2CN(CC3=CC4=CC=CC=C4C=N3)C[C@@H1]21 CN1CC(C(=O)N[C@H1]2CCC[C@@H1](CNC(=O)C3=CC(C(F)(F)F)=N[NH1]3)C2)C1 CC1=CC=C(C(=O)NC[C@@H1]2C[C@@H1](CNC(=O)CS(=O)(=O)C(C)C)CO2)N=N1 CC(=O)OC(C)(C)C(=O)NC[C@@]1(C)CC[C@@H1](NC(=O)C(F)(F)C2=CSC(C)=C2)C1 C=C(C)CCN1CCC[C@H1](NC(=O)C[C@@H1](C)C2=CC=CC=C2C)CC1 CC1=C(C(=O)N(C)[C@H1]2CCN(C(=O)CN3CC(=O)NC3=O)C[C@@H1]2C)CCCO1 CC1=CC=C([C@@H1](CO)NC(=O)CC2(C)CN(CC3=NC=C(Br)C=C3C)C2)C=C1 NC1=CC(Cl)=NC=C1C(=O)NCC[C@@]23CC[C@@H1]2CN(C(=O)C4(CO)CC4)C3 CC1(C)C[C@@H1]1C(=O)NC2(CC(=O)N[C@]3(C)CCC(=O)NC3=O)CC2 CCN(CC)CCCCNC(=O)[C@H1]1CCCN1C(=O)[C@]2(C)CC=CCC2 CN(CC1=NC(=O)O[NH1]1)C(=O)[C@@H1](CO)NC(=O)C=2C=C(CCO)ON=2 CC(C)[C@@](C)(CNC(=O)C1=CC=C(C2=CC=CC=C2)[NH1]1)NC(=O)CN3C=NN=N3 C[C@@H1]1CCN(CC(=O)N2CC[C@H1](O)[C@@H1](N(C)C(=O)C(=O)NC3CC3)C2)C1 CN1CC=C(CC(=O)N[C@H1]2C=CC[C@H1](C(=O)NC[C@H1](F)CO)C2)CC1 CCCCS(=O)(=O)CC(=O)NC[C@@H1]1C[C@@H1](NC(=O)[C@H1](CC)CC(F)(F)F)[C@H1]C1 CCN(C(=O)[C@@H1]1C[C@H1]2C[C@@H1]1C[C@H1]2NC(=O)[C@H1](C)C3=CC=CC=C3)[C@@H1]4CCCOC4 CSC1=NN(C)C=C1C(=O)N[C@]2(C)C[C@H1](NC(=O)CC[C@H1]3CCC(=O)N3)C2 CC(Cl)=CC(=O)N(C)[C@@H1]1CCCC[C@@H1]1NC(=O)C2CCN(CC(F)(F)F)CC2 COC1=CC=C(CC(=O)N[C@@H1]2[C@H1]3C[C@@H1]2N(C(=O)[C@H1]4C[C@]45CC5(F)F)C3)C=C1Cl CC(C)(C)C(=O)N[C@@H1]1C[C@H1]2CC[C@H1]1N(C(=O)CC[C@H1]3CC[C@@H1](O)CC3)C2 CN1CCC(C(=O)N[C@H1]2CCCCN([C@H1](C)C3=CC=C(S(C)(=O)=O)C=C3)C2)CC1 CCO[C@@H1]1C[C@H1]1C(=O)N2CCN(C(=O)CCCCCCC(=O)OC)[C@@H1](CF)C2 CO[C@@H1](C(=O)NC1(C)CN(C(=O)[C@@H1]2CCCC3(CCC3)O2)C1)C=4C=NN(C)C=4 COC(=O)C1=CC(C)=NC(N(C)[C@H1]2CC[C@@H1](NC(=O)C=3C=NOC=3C4CC4)C2)=N1 CC1=NO[C@H1](C(=O)NCC2C(N(CCO)CC3=CC(C)=CC=C3F)CC2)C1 CC(C)N1C=C(C(=O)N[C@H1]2C[C@@H1]3C[C@H1](NC(=O)CC4(N(C)C)COC4)[C@@H1]3C2)C=N1 C#CCOCCN(C)C(=O)[C@@H1](C)N(C(=O)C1=NC=NC=C1Cl)C2CC2 CC1=CC(N(C)CCCNC(=O)C=2OC=CC=2C(C)C)=NC(CC3CC3)=N1 CC1=C(C(=O)N[C@H1](C)CCNC(=O)C[C@]2(O)CCCOC2)C=C(C3CCC3)N1C CC[C@H1](CNC(=O)[C@H1]1CC(C(C)C)=NO1)NC(=O)C2=CN=C3C(=C2)N=CN3C CO[C@@H1](CNC(=O)[C@@H1](NC(=O)[C@@H1]1CCCCCN1C)C2=CC=CO2)CSC COC(=O)[C@H1]1[C@H1]2CC[C@H1](C2)CN1[C@H1](C(=O)NC3CCCC3)C4=CCCCCC4 C[C@H1](C(=O)N1CCOC[C@](C)(CNC(=O)C2CC(F)(F)C2)C1)C3(O)CCC3 CN1C(O)=NC=C(C(=O)NCCCCNC(=O)CS(=O)(=O)CC(F)(F)F)C1=O C#CC1=C[NH1]N=C1C(=O)N[C@@H1](CN=[N+1]=[N-1])C(=O)N(C)[C@H1]2CC[C@@H1](O)CC2 O=C(NCC(=O)N1CCCC1)[C@@H1]2COC3(CCN(C(=O)[C@@H1]4CC=CCC4)CC3)C2 C#CCCCN(C)[C@H1](C(=O)NC(C)C)C1=CC(I)=CC=C1F CC[C@@H1](C(=O)N1CC[C@@](CO)(NC(=O)C2=CC=CC3=C2CCO3)C1)N4C=CN=C4 CC1=CC(C(=O)N2CC3(CN(C(=O)C4=C[C@@H1]5CCC[C@@H1]45)C[C@@H1](C)O3)C2)=NS1 C[C@H1](CC(=O)NC[C@H1]1[C@H1](C)CCN1C(=O)C2=CC=C(F)N=C2)C(F)F CCO[C@@H1](C(=O)N1C[C@H1]2CCN(C(=O)C[C@@H1]3CCC(=O)NC3)[C@H1]2[C@@H1]1C)C4CC4 CCN1CCC[C@H1](CNC(=O)[C@](C)(NC(=O)C2CC3(CCC3=O)C2)C4CCC4)C1 O=C1NCCCC=2OC(C(=O)N[C@H1]3C=CCN(C(=O)C45CC(CO4)C5)C3)=CC=21 CC(C)(C)COCC(=O)N1CCOC[C@H1]1CC(=O)NCCC2=NC=C[NH1]2 CS[C@H1](C)[C@@H1](C)N(C)C(=O)C1([C@H1](C)NC(=O)C=CC2=CN=CS2)CC1 CC(=O)NC1C[C@@H1]2CC[C@H1](C1)N2C3=NC(N(C)CCC4=CC=CS4)=NC5=C3SCC5 O=C(CCOC[C@H1]1CCCO1)NC[C@H1]2CC3(CC3)CN2C(=O)C4CC4 C=CCN1C=CC=C1C(=O)N2CCCC[C@]3(CCN(C(=O)C45CC(C4)C5)C3)C2 COC1=CC(C2=C[NH1]N=C2C(=O)NC3=CC(I)=CC=C3C)=CC=C1C(F)F C#CCOC1=NC=CC=C1C(=O)NCC2(NC(=O)C3=CC(C)=NO3)CCOCC2 C#CCOCCC(=O)N1CC[C@](C#N)(NC(=O)C2=CC=C(S)C=C2)C1 CCOCCO[C@H1](C)C(=O)NC[C@@H1]1C[C@@H1](OC)CN1C(=O)C2=CC(O)=CC(O)=N2 C[C@H1]1N(C(=O)C2(CNC(=O)[C@H1]3O[C@H1]4CC[C@H1]3C4)CCCCC2)CCCC1(C)C COC(=O)C1=CN(CC(=O)NCCC[C@@H1](C)NC(=O)CC2=CSC(Cl)=C2)N=N1 C#CC1(OCC(=O)N2CCC[C@H1](NC(=O)CCOCCOC)C2)COC1 CC(C)C=CN=C(Cl)CNC(=O)[C@@H1]1[C@@H1]2C[C@H1]1N(C(=O)[C@@H1]3CCCCC3(F)F)C2 C#CC[C@H1](CC(=O)NC[C@H1](C)C1=NN=CN1C)NC(=O)C=2OC=NC=2C3CC3 C[C@@H1](CCC1=CC=CC=C1)[C@@H1](C(=O)NC2CCCCC2)N(C)CCOCCO O=C(N[C@@H1]1CCN(C(=O)C2=CC=NC(C(F)F)=C2)C13CCC3)C4=CC=NC=C4 O=C(CCC1=CN=CS1)N[C@H1](CNC(=O)C2[C@H1]3COC[C@H1]23)C4CCCC4 C=CCCO[C@@H1](C)C(=O)NC[C@H1](C)CNC(=O)C1=CC=CN1CC2=CC=CS2 O=C1CC[C@@H1](C(=O)N2CCC[C@H1](C(=O)NCCC3=NC=CS3)CC2)N1 COC1=CC=NC(C(=O)N[C@H1]2COCC[C@H1]2NC(=O)CC3=CC=C(Cl)N=C3)=C1 N=C1N=C(CNC(=O)[C@H1]2CC23CCN(C(=O)CC4CC(F)C4)CC3)[NH1][NH1]1 CCC[C@@H1]1C[C@H1]1C(=O)N2CC(CCNC(=O)[C@@](O)(C3=CC=CC=C3)C(F)(F)F)C2 O=C(C[C@@H1]1CC2=CC=CC=C2NC1=O)NC3CN(C(=O)C=4C=C(CO)ON=4)C3 C[C@@H1]1CN(C(=O)C2=CC=CC3=C2CCO3)C[C@H1]1NC(=O)C=CC=C(Cl)Cl CC[C@@H1](CNC(=O)C=1C=C(C)N(C2=CC=CC=N2)N=1)NC(=O)C3(Cl)CC3 O=C1NC[C@@H1](C(=O)NC2([C@H1]3CCCN3C(=O)C4CC5(CC[C@@H1]5O)C4)CC2)N1 O=C(N[C@@H1]1CCC[C@H1]1CF)C2=CN=CC(CNC(=O)C=3C=CSN=3)=C2 CCC12CN(C(=O)[C@@H1](O)CSC)C(CNC(=O)C3=CN(C)C=C(Br)C3=O)(C1)C2 CC[C@H1]1C[C@@H1](CC(=O)N[C@@H1]2CN(C(=O)C(F)F)CC2(C)C)CCO1 CNC1=CC=CC=C1C(=O)N2CC(NC(=O)C3=CON=C3C)(C4=CC=CC=C4)C2 C#CCOCCNC(=O)C1=CC2=CC=C(C3=CC=C([S@@](C)=O)C=C3)C=C2S1 CC1=NC(C(=O)NC(C)(C)[C@@H1]2CCCN2C(=O)[C@H1]3CC=C(C(C)C)CC3)=NN1C O=C(CC1=CSC(S)=N1)N[C@@H1]2CCN(C(=O)[C@]3(CO)CCCO3)CC24CCC4 CC=1SC(Br)=NC=1CNC2(C3=NN=NN3[C@@H1]4CCOC4)CCC5(C=CCO5)CC2 CCOCCCCCC(=O)N1CC[C@]2(C[C@H1]2NC(=O)CCCCN3C=CN=N3)C1 C[C@@H1]1CC[C@H1](NC(=O)CCCC#N)CN1C(=O)CCOC2=CC=C(Cl)C(Cl)=C2 O=CN[C@@]1(CO)CCN(C(=O)CCS(=O)(=O)NC=2C=NSC=2)C1 C#CCN(CCO)C(=O)C1=C[NH1]N=C1[C@H1]2CCCCN2C(=O)[C@@H1](CC)C/C=C/C CCC1(CNC(=O)[C@H1]2C[C@H1](NC(=O)C3=CC(O)=NN3C)C2(C)C)CCOCC1 CC1=CC=C(C(=O)N[C@@H1]2CC23CCN(C(=O)C[C@H1](C)C(C)C)CC3)C(C4CC4)=C1 CCC(=O)N1CC=C[C@@H1]1CNC(=O)C2=C[NH1]C(Br)=C2 CCOC(=O)[C@@H1](OC)C(=O)N1C[C@H1](CC(=O)N[C@H1](C)C2=CN=N[NH1]2)C3(CC3)C1 C#CCCO[C@H1](C)C(=O)N[C@@H1]1C[C@H1]2CC[C@@H1]1N2C(=O)C3(OCC)CCCC3 COC1=CC=C2[NH1]N=C(C(=O)N[C@H1](C)C(C)(C)NC(=O)[C@@H1]3CN4CCC3CC4)C2=C1 O=C(CC=CC1=CC=CC=C1F)N[C@H1]2CC[C@H1](NC(=O)[C@H1]3C[C@@H1]3[N+1](=O)[O-1])C2 CC(C)(C)C1=CC=C(CNC(=O)[C@@H1]2[C@H1]3CC[C@H1](C3)N2C(=O)C4CC(F)(F)C4)C=C1 COCCOC1=NC=CC=C1C(=O)NC2CC(CNC(=O)[C@@H1]3CC3(C)C)C2 CN(C)CCC1(C(=O)N[C@@H1](CN=C2N=N[NH1]N2CC3=CC=CC=C3)C4CC4)CC1 C[C@H1]1C[C@H1]1CC(=O)NCCOCCN(C)C(=O)C2=CC=C(N(C)C)N=C2 O=C(N[C@H1]1CCO[C@H1]1C(=O)NOCCCO)C2=CC=C(CO)O2 C[C@H1](CC(=O)NC[C@@]1(F)CCOC1)C(C)(C)NC(=O)C[C@@H1]2C=CCCC2 CSCC[C@H1](C(=O)N[C@H1]1CC[C@@H1](NC(=O)C2=COC(C)=N2)CC1)N(C)C CC[C@H1](C)[C@@H1](CO)NC(=O)[C@@H1]1[C@H1]2CN(C3=NC(C)=NC(C)=C3F)C[C@H1]21 CCCCCCCCC(=O)N[C@@H1]1[C@H1]2C[C@@H1]1N(C(=O)C3=CC(O)=CN=C3Cl)C2 CCC=1C=COC=1C(=O)N[C@H1]2C[C@@H1](CCC(=O)N[C@@H1]3CCS[C@H1](C)C3)C2 CCN1N=NN=C1[C@@H1](CCC2=CC=C(C(=O)OC)C=C2)NCCC3=CC=NC(Cl)=C3 C=CCN1C=C(C(=O)N[C@H1](CCC)C(=O)N2CC[C@@H1]2CC(C)C)N=N1 CO[C@@H1](C)[C@@H1](NC(=O)C1=CC(Cl)=C(OCC2=CC=C(I)C=C2)C(Br)=C1C)C(=O)O CC1(C)CC[C@@H1](CC(=O)N2CC3(C2)CN(C(=O)[C@H1]4C[C@@H1]5CC[C@H1](C4)S5(=O)=O)C3)C1 CN(CCO)C1=CC=C(CNC2CCN(CC3CCCC3)CC2)C=C1 CN(C)C[C@@H1](O)CN(C)C(=O)[C@@H1](O)C1CN(C(=O)C2=CC=C(O)N=N2)C1 CC(C)C(CC(=O)N[C@@H1]1C[C@H1](C)N(C(=O)C2=CN=CC(F)=C2Cl)C1)C(C)C CC(=O)N(C)[C@H1](C)C(=O)NCC1(CC(=O)NCCC2=NC=C(C)O2)CC1 CC(C)(CNC(=O)C[C@H1]1C[C@@H1](OCC2=CC=CC=C2)C1)N3C=CC=N3 CSC[C@@H1]1CCN(C(=O)[C@@H1]2CSCN2C(=O)C3=CC=CN=C3O)C1 CC1=CC=C(C)C(CN[C@@H1]2CN(C(=O)C3=CC(Cl)=NC=C3Cl)CC24CC4)=C1O CC1=C(F)C=CC=C1C(=O)N2C[C@@H1](CNC(=O)CC3=C(O)N=CN=C3O)C[C@@H1]2C C=C(Cl)C(C)(C)C(=O)NC[C@H1](F)CNC(=O)[C@@]12CCCN(CC1)C2 CC(C)COCC(=O)N1[C@H1](C(=O)NCC[C@@H1](C)N2CCC2)CC[C@H1]1C3CC3 C#CC1=CC=C(OCC(=O)N2CC[C@@H1]2CNC(=O)[C@H1]3C[C@H1](C(F)F)C3)C(OC)=C1 CN1C[C@H1]2[C@@H1](C1)[C@@H1]2C(=O)N3CC([C@@H1](O)C(=O)N4CC([C@H1]5CC5(F)F)C4)C3 C/C=C/CCCCC(=O)N1C[C@@H1]2CC[C@H1](C1)N2C(=O)CCCCSC CCCC1=NN=C(SC2=NC=CC(OCCOC)=N2)N1C[C@@H1]3CCCO3 ClC1=CC=CC2=CC(CN[C@H1](C3=CC=C(F)C=C3)C4=CC=CC=N4)=CN12 CC=C(CC)C(=O)N1CCC2(CC1)CO[C@H1](CNC(=O)C3CC4=CSC=C4C3)C2 COC1(CC(=O)N[C@H1]2C[C@@H1]2NC(=O)C3=CC4=C(C=C3O)CCCC4)CCCC1 CC=1OC=C(C(F)(F)F)C=1C(=O)N(C)CCNC(=O)[C@@H1]2C[C@H1]2C#N CCC(CC)[C@@H1](O)CNC(=O)COC(C)(C)CNC(=O)CCC1=NC(C)=NO1 C#CC(C)(C)C(=O)N[C@H1]1CCN(C(=O)CCCCC(=O)OCC)C[C@@H1]1O CN(CCCNC(=O)C=1C=CON=1)C(=O)C2CCC(C3=CC=CC=C3)CC2 CC1=C(C(=O)N2CC[C@@H1]2CNC(=O)COCC(F)F)[NH1]C3=CC(Cl)=CC(Cl)=C13 CN1CC2CC1(CNC(=O)[C@H1](CN3C=CC=N3)NC(=O)C=CC4CC4)C2 CCO[C@@H1]1C[C@H1]1C(=O)N2CCN(C(=O)C3=CC=C(C)C(C)=C3N)C[C@H1]2C C=CC(C)(C)CC(=O)N(C)CCCN1C=C(C2=CC(OC)=CC=C2OC)N=N1 O=C(CC(=O)NC1CC1)NCC2(NC(=O)[C@@H1]3C[C@@H1]4C=C[C@H1]3C4)CCCCC2 CC1=CC=CC=C1[C@H1](N)C(=O)NC[C@H1](CO)CC2=CC=CO2 CC(C)C(=O)NC[C@H1]1CC[C@H1](NC(=O)C2=C[C@@H1]3CCCC[C@H1]23)CC1 COC1=CC=CC(NC(=O)[C@H1](C=2N=C[NH1]N=2)N3CC[C@]4(C=CCO4)C3)=C1 CC(C)[C@H1](CNC(=O)C1=CC=CN=C1Cl)NC(=O)CC2C[C@H1]3C[C@@H1]3C2 CC[C@@H1](CSC)NC(=O)/C=C/CC(C)(C)NC(=O)C1CCN(C)CC1 CO[C@@H1]1CN(C(=O)C[C@H1]2[C@H1]3CCC[C@H1]3N2C(=O)C(C(C)C)C(C)C)C[C@H1]1O CC[C@@H1](CC1CCCC1)C(=O)N(C)C[C@@H1]2CCCN(C3=NN=NN3C)C2 CCC1=NC(C)=C(C(=O)NC[C@@H1]2CCN2CC3=CC=CC=C3Cl)S1 CS[C@H1]1C[C@H1](C(=O)NC2C[C@@H1]3CC[C@H1](C2)N3C(=O)/C=C/C4=CSN=C4C)C1 CCCN(C(=O)[C@H1]1C[C@H1]2CCC[C@H1](C2)C1)CC3=CN(C(C)C)N=N3 CCN1N=CC=C1C(=O)NC[C@H1]2CC[C@H1]2NC(=O)[C@H1]3CCC[C@@H1]3O CC/C=C/CC(=O)N1C[C@@H1](F)C[C@H1]1CN(C)C(=O)[C@@H1]2CCN(S(C)(=O)=O)C2 CSC[C@H1](C)C(=O)N1CC(OCCNC(=O)CCC2=CC(C)=CC=C2Br)C1 CN(C)C1=NC2=CC(NC(=O)C3=CC(C(=O)N4CCOCC4)=C[NH1]3)=CC=C2O1 O=C(CN1C=CC(Br)=N1)NC2=CC(Cl)=CC=C2C(=O)C3=CC=C(F)C=C3 C[C@@H1](SC1=NC=CC=N1)C(=O)N(CCNC(=O)C2=CC=NS2)C3CCCCC3 CCC(CC)N(CC)C(=O)C[C@@H1](NC(=O)C1=CN=CC(C)=C1)[C@@H1](C)OC CC=1C=NN(CC(=O)N[C@@H1]2C[C@H1]2[C@@H1]3CCCN(C(=O)C=4C=NSC=4C)C3)C=1 CO[C@@H1]1C[C@@H1](CNC(=O)CC2(O)CC2)N(C(=O)C3=COC(C(F)F)=N3)C1 CCC(=CC(=O)N1CCC2(CC1)CN(C(=O)C=C3CN4CCC3CC4)C2)CC COC1=CC(OC2CC2)=CC=C1C(=O)N[C@H1]3C[C@H1](NC(=O)C(C)(C)SC)C3 O=C([C@@H1]1[C@@H1]2CC[C@]21C3=CC=CC=C3CO)N4CC[C@H1](OC5=CC=CC=N5)C4 CCN(C(=O)C12CC(C(C)(C)C)(C1)C2)[C@@H1](C3=CC=CN=C3)C4(CC)CC4 O=C1N[C@H1](CCCCCCCC2CC2)C(=O)N1CCCNS(N)(=O)=O CC(C)(C)[C@@H1](O)C(=O)N1CC(CNC(=O)CC=2C=CSC=2Cl)(C(C)(C)O)C1 CC[C@@]1(C(=O)N2CCCN(C(=O)C(=O)N=C3C=C(C)O[NH1]3)[C@@H1](C)C2)CCCO1 C[C@@H1]1NC(=O)CC[C@H1]1CNC(=O)/C=C/C2CCN(C(=O)C=3N=C[NH1]N=3)CC2 CC1=CSC(C(=O)N2CCC[C@H1]2/C=C/C(=O)N[C@H1](C)C3=CC=C(O)N=C3)=C1 C=CC(C)(C)C(=O)N1CCC([C@H1](C)NC(=O)C2=C[NH1]C(C3=CC=NC=C3)=N2)CC1 O=C(CCCF)NCC1(CC(=O)N[C@@H1]2CCOC[C@H1]2F)CC1 NS(=O)(=O)CCC(=O)N1CCC[C@H1](C2CCN(C(=O)C3(C4CC4)CC3)CC2)CC1 CCCC(=O)NCC(=O)N1C[C@H1](NC(=O)CCN(C)CCC(C)(C)C)C2(CC2)C1 CCOC1(C(=O)N2CC3(C[C@H1](NC(=O)C45CC6C[C@H1]4[C@H1]5C6)CO3)C2)CCCC1 CN(C(=O)C1=CC(Cl)=C(Cl)C(Cl)=C1Cl)C2CN(C(=O)CC3=CC=CC(Cl)=C3F)C2 CC(C)[C@H1](C)[C@@H1](CNC(=O)/C=C/C1=CC=C(Br)C=C1)NC(=O)C2(O)CCC2 CC(C)CCC(=O)NCC12CC(CN1C(=O)C3=CC=C4N=C(O)[NH1]C4=C3F)C2 C[C@@H1](C(=O)NCC[C@H1]1CN(C(=O)C2=CN=CO2)CCCO1)[C@@H1]3CCC(=O)N3 CC1(C)OCC[C@H1]1CC(=O)N2C[C@@H1](C(=O)NC3=C[NH1]C4=CC=CC=C34)C5(CC5)C2 COCCC[C@@H1](C)C(=O)N[C@@H1](CNC(=O)C(=O)C1=CC=C(F)C=C1)C2CC2 C=C(Br)CC(=O)NC[C@H1](CC)NC(=O)C1(OCC)CCC1 CNS(=O)(=O)CCC(=O)N1CCC[C@H1]1C(C)(C)NC(=O)[C@@H1](F)C(C)(F)F C[C@@H1](NC(=O)C=1C=COC=1)C(=O)NC[C@@H1]2CCCCN2C(=O)C3=CN=C[NH1]C3=N C[C@@H1](CCNC(=O)C1=CC=C2C(=C1)CCCO2)N(C)C3=NC=NC(=N)[NH1]3 COC1=CC=C(Cl)C=C1C2=NN=C(N3C[C@@H1]4C[C@H1]4C3)N2C[C@H1]5CCCCO5 C=CCOCCCC(=O)N1CC[C@H1](NC(=O)CO[C@@H1]2CCCC[C@H1]2CC)[C@@H1]1C CC[C@H1](C)[C@H1](O)C(=O)N1CC[C@@H1](C)[C@@H1](CNC(=O)CNC(=O)C=CCl)C1 C[C@H1](NC(=O)C=1C=NN(C)C=1F)[C@@H1]2CCCCN2C(=O)CCC(C)(C)F CCN(CC)C[C@H1](O)CNS(=O)(=O)C1=CC=CN=C1N(C)C[C@@H1](C)C#N CO[C@@H1]1[C@H1](NC(=O)N[C@H1]2CCCN(C3=CC=CN=N3)C2)CC14CCC4 CCO[C@@H1]1CN(C(=O)CC=2[NH1]C=NC=2C)C[C@H1]1CNC(=O)C=3OC=CC=3C CC1=NNC(=O)[C@@H1]1CCC(=O)NC[C@H1](CO)NC(=O)CCCP(C)(C)=O CC(C)C[C@H1](C(=O)N1C[C@@H1](F)C[C@H1]1CNC(=O)CN2CC(=O)NC2=O)N(C)C CC[C@H1](C(=O)NC1CC(N(C)C(=O)C2=NOC=C2C)C1)N3C=NC(C#N)=N3 O=C(NC1=CC=CC(CO)=C1)C(=O)N[C@@H1]2CCCC[C@H1]2F COCCN1C=NN=C1CCN=C2[NH1]C(=N[C@@H1](C)[C@@H1]3CCCO3)C4=CC=CC=C4[NH1]2 C[C@H1]1CN(C(=O)C(F)(F)[C@H1](O)C2CC2)CC[C@H1]1NC(=O)C=3SC=CC=3C(F)F CC1=CC2=CC(CCN(O)C3=COC(=O)C=C3)=C(C)OC2=C1 CC[C@@H1](C(=O)NC[C@@H1]1CCCO1)N2C=C(COC3=CC=CC(C)=C3)N=N2 CN(CCCCN(C)C(=O)C=1N=COC=1CCC(F)(F)F)C(=O)CCF C=C1CC[C@@]1(C(=O)NC/C=C/CNC(=O)C2=CC=C(SCC)C=C2)C(=O)OC CCC1=CC=CC=C1C(=O)N[C@@H1]2C[C@H1]3CC[C@@H1]2C[C@H1]3NC(=O)CC[C@@H1](C)N(C)C COC[C@](C)(OC)C(=O)NCCO[C@@H1]1CCN(C(=O)[C@H1]2CC[C@H1](C)CC2)C1 O=C(NCCC(=O)N1CC=C[C@H1]1CNC(=O)[C@@H1]2[C@H1]3CCCO[C@H1]32)C4=CC=C(Cl)S4 CCN(CC)CC(=O)NC[C@H1]1CCN(C(=O)C2CC(OC)(OC)C2)C[C@H1]1O COC[C@H1](C)CN(C)C(=O)[C@@H1](F)CC(C)(C)NC(=O)CCCN(C)C(C)C CC1=NC=NC=C1C(=O)NC2=NC(CC(=O)NCC3CC(F)(F)C3)=CS2 O=C(C[C@@H1](NC(=O)[C@@]1(O)CCOC1)C(F)F)NCCCSCCO CC1(C)C[C@@H1]1NC(=O)[C@H1]2CC[C@H1](N3C=C(C4=CC=CS4)N=N3)C2 N#CCNC(=O)[C@@H1]1CC12CCN(S(=O)(=O)C3=CC=C(Cl)C=C3)CC2 O=C1C[C@H1](CC(=O)N2C[C@H1](CNC(=O)[C@H1]3CCS(=O)(=O)C3)C4(CCC4)C2)C(=O)N1 CC1=NC(N)=CN=C1C(=O)N[C@@H1]2CC[C@@H1]2CNC(=O)CCCSC(C)(C)C CSC[C@](C)(O)CNC(=O)[C@H1](CN(C)C)NC(=O)C1[C@H1](C)[C@H1]1C C[C@H1](O)CCC(=O)NC[C@H1]1C[C@H1]2CC[C@H1]1N(C(=O)C3=CC=C(O)C=C3O)C2 C[C@H1](NC(=O)C=1C=C2N(N=1)CCCN2)[C@@H1](C)NC(=O)C=3N=NN(C(C)(C)C)N=3 COC[C@@H1](OC)C(=O)NCC1CN(C(=O)C2=CC(O)=NC3=CC=C(F)C=C23)C1 COCCCCCC(=O)N(CCN(C)C(=O)C1=CC(OC)=CN=C1F)C(C)C O=C1NC[C@]2(CCN(C(=O)[C@@]3(NC(=O)[C@H1]4C[C@@H1]5CC[C@H1](C4)O5)CCSC3)C2)O1 CCC1CC(C(=O)N2CCO[C@H1](CC(=O)N3CCC[C@@H1](O)CC3)C2)C1 C=C(C)CC(=O)N1CC(C)(C)C[C@@H1]1CNC(=O)[C@](C)(F)C2=CC=C(F)C=C2 C[C@@H1]1CCN(C(=O)C=2C=CN(CC(F)F)N=2)CCN1C(=O)C3=CC(Cl)=CC=N3 CCN(CC)CC1=CN(CC2=CC=C(C(=O)N3CC=CC3)O2)N=N1 CN(C(=O)CCNC(=O)COC=1C=CN(C)N=1)[C@H1]2CCCC[C@]2(C)O COC1(CC(=O)N2CC=CC23CCCCC3)CN(C(=O)C4CC5(CC5)C4)C1 C[C@@H1](C[C@@H1](C)NC(=O)C1=CC=NN1CCC(F)(F)F)NC(=O)CC2=CCCC2 O=C(NCCOCCNC(=O)C12C[C@@H1]3CC1(CO)C[C@@H1]3C2)[C@H1]4CC4(F)F CC=1C=NN(C)C=1CC(=O)N[C@H1]2CCO[C@H1]2C(=O)N3CCOC(C)(C)CC3 CCOC1=CC=CN=C1C(=O)NCCC2(CNC(=O)[C@@H1]3C[C@]3(CC)C(C)C)CC2 C[C@@H1](NC(=O)C1=CN(C)N=C1C2=CC=CS2)[C@H1]3CCCN(C(=O)C(=O)N(C)C)C3 CC[C@@]1(C)CN(C(=O)[C@@H1]2C[C@H1](F)CCN2C(=O)CC3=CC=CO3)CCO1 CNC(=O)C1=CC=C(NC(=O)N2CCCC[C@H1]2CCN3CCN(C)CC3)N=C1 C=C1CC(C(=O)NC[C@@H1]2CN(C(=O)C=3OC=CC=3CC)[C@@H1]C4CCC[C@H1]24)C1 CC[C@H1](CC(=O)N(C1CC1)[C@H1](C)C(=O)NC[C@H1](OC)C2CCC2)C3CC3 CC1=COC=C1C(=O)NC2CC3(C2)C[C@H1]3NC(=O)CC4(O)CCC4 CC(C)CC1(C(=O)N(C)C[C@H1](O)CN(C)C(=O)C2=COC=N2)CC1 CN(CC1(NC(=O)COC2(C)CCC2)CC1)C(=O)[C@@H1]3C[C@H1]4C[C@@H1]3C[C@H1]4O COC(=O)C1=CC(OCC(C)(C)[C@@H1]2CCCCN2C(C)=O)=CC=C1C CC1=CC2=CC=CC=C2C=C1C(=O)N[C@@H1](C(=O)O)C34CC5CC(CC(C5)C3)C4 CC(=O)N1CC(C(=O)NCC2CC3(C2)CN(C(=O)C=4C=CSC=4)C3)C1 CC1=CC(C(=O)N2CCC[C@H1]([C@@H1]3C[C@H1]3NC(=O)CC(C)C)C2)=NN=C1O CCN1N=C(C(=O)NCC2(OC)CCN(C(=O)[C@]3(C)C[C@H1]3Br)CC2)C=C1C4CC4 CCC[C@@H1](CC)C(=O)NC[C@@H1](NC(=O)C1=NC=CN1C(C)C)C(C)(C)C CN1CCC(C(=O)NC[C@H1](F)CNC(=O)[C@H1](F)OC2=CC=C(Cl)C(F)=C2)CC1 CSC1(C(=O)N[C@@H1]2C[C@@H1]3C[C@H1](NC(=O)CC4=CCOCC4)C[C@@H1]32)CC(O)C1 CC1(C)C[C@@H1]([C@H1](C(=O)NC[C@@H1]2CCOC2)N3CCO[C@H1](C(F)(F)F)C3)CCS1 CC=1C=C2N(N=1)CCN(C(=O)[C@H1]3CCCN(C(=O)CCC4=CC=CN=C4)C3)C2 CC(C)N1CCC(C(=O)NC[C@H1](O)CCNC(=O)C[C@H1]2CC3(CC3)CO2)CC1 COC(OC)C(=O)N[C@@H1](CNC(=O)C=1SC(C)=CC=1Cl)C2=CC=CC(C)=C2 CC1=CC=CC(F)=C1CC(=O)N[C@H1]2C[C@H1](NC(=O)C[C@@H1]3CC=CCC3)C2 C#CCCCC(=O)NCC[C@@H1]1CN(C(=O)C2(CC=C)CC(=O)C2)CCCO1 CC(=O)NCC(=O)N1CCN(C(=O)CN2C=CC(C(F)F)=N2)[C@H1](C)[C@@H1]1C CC1=CC=C(CN(C)C2=NC(=N[C@@H1](C)CCCCCO)[NH1]C3=C2SCC3)C=C1Cl CC1=NN(C(C)C)C=C1C(=O)N[C@@H1](C)C(C)(C)NC(=O)[C@H1](C)C2=CC=CO2 CN(CCNC(=O)C1=CN=CO1)C(=O)C2=CC=C3C=C(Cl)C=CC3=N2 CC1=CC(Cl)=CC=C1C(=O)N(C)C2CC(NC(=O)C3=CC=CC(C(C)C)=N3)C2 O=C(CC=1SN=CC=1Br)NCC2=CN3C=NN=C3C=N2 CC(C)CN1CCN(C(=O)[C@@]23C[C@@H1]2CCN3C(=O)C4CC5(CC5)C4)CC1 CC1(C)CCCN(C(=O)C(=O)C2CCOCC2)[C@@H1]1C(=O)NC(C)(C)CCF CN(CC1(CNC(=O)C2=CN=NC(O)=C2)CC1)C(=O)C=CC3CC3 C[C@H1]1CCCN1CC(=O)N[C@H1]2C[C@@H1]3C[C@H1](NC(=O)CN4C(=O)CN(C)C4=O)[C@@H1]3C2 CN(C)CCCC(=O)NC[C@@H1](NC(=O)CC1COCCOC1)C2CC2 CN(CCC[C@@H1]1CCCO1)CC2=CC=CC=C2NC3=CC=CC=N3 C[C@@H1]1CN(CCCS(C)(=O)=O)CCN1C(=O)C2=CC=NC(C3=CC=CO3)=C2 C=CC(C)(C)CCNC(=O)[C@H1](F)C1(O)CN(C(=O)[C@H1]2C[C@@H1]2[N+1](=O)[O-1])C1 COC(=O)[C@H1](C)C(=O)N1CCN(C(=O)[C@@H1]2CCC3=C[NH1]N=C3C2)[C@@H1](C)C1 CC[C@H1](C)[C@H1](O)C(=O)N[C@@H1]1CN(C(=O)C=2SC=NC=2Br)C[C@H1]1O CSC(C)(C)CC(=O)N1CC[C@H1]2CCN(C(=O)C(C)(C)C3=CC=CC=C3)C[C@H1]21 CC1=CC=C(C(=O)N2CC[C@@H1](NC(=O)C3=CC(C4=CC=C(Cl)C=C4)=NO3)C2)N1C C[C@@H1](OCCN(C)C)C(=O)NCCC[C@H1](NC(=O)[C@@H1]1C[C@@H1]1C)C2=CC=CC=C2 CC(C)[C@@H1](COC1=CC=CC(Cl)=C1)NC(=O)[C@@]23CCC[C@@H1](C2)O[C@H1]3C C#CCCNC(=O)[C@@H1]1C=C[C@H1](NC(=O)C=CC2=CN(C)C=N2)C1 CCSCC1=CC=C(C(=O)NC2C(C3(NC(=O)C4=NC=C(N)C=C4Cl)CC3)C2)C=C1 CN1CCC[C@@H1]1C(=O)N[C@H1]2CCN(C(=O)CN3C[C@H1]4C=C[C@H1]3C4)C[C@@H1]2F C[C@@H1](C(=O)N[C@H1]1COC[C@H1]1NC(=O)C2=CSC(C3=CC=CO3)=N2)C4=CCCC4 CC[C@@H1]1CCC[C@]1(C)C(=O)N(C)CCCOCCNC(=O)CCC2=CN=CC=N2 CC[C@H1](OC)C(=O)N[C@H1](C(C)C)C1CCN(C(=O)C=2N=C(C)OC=2C)CC1 C=CC[C@H1](NC(=O)C1(F)CN(C(=O)CC2(OCC)CC2)C1)C(=O)OCC CCC(=O)NC[C@]1(O)CCN(C(=O)C=2C=C(S(N)(=O)=O)SC=2Cl)C1 CC1=CN2C=CC(C(=O)N[C@@H1](C)C3CCN(C(=O)C(=O)NC4CC4)CC3)=CC2=N1 C#CC[C@]1(C(=O)N[C@@H1](CO)COCC)CCN(C(=O)[C@@H1]2CCC[C@H1](O)C2)C1 CCOC(=O)C1(CN[C@H1](C)C[C@@H1](C)CCN)CC1 COC1=NC(C)=C(C(=O)N[C@]23CC[C@H1]2CN(C(=O)CC=4C=NN(C)C=4C)C3)S1 CC=1C=NOC=1C(=O)N2CC[C@@](C)(CNC(=O)[C@@H1](O)C3CCC3)C2 CC(C)(O)C(F)(F)C(=O)NC[C@]1(F)C[C@H1](NC(=O)[C@H1]2CCC[C@H1](C(F)(F)F)O2)C1 CC(C)(C)CC[C@@H1](F)C(=O)N1CC(=O)C[C@@H1]1C(=O)NCCC(=O)NO CN(C)CCCCC(=O)N1[C@@H1](CC(=O)NCCC(F)=C(F)F)[C@H1]2CCC[C@H1]21 CN(C[C@H1]1CCCN1C(=O)C2=CC=C(C3CC3)C=C2F)C(=O)C4(F)CCC4 CC(=O)N1CC(CC(=O)N[C@H1]2CCC[C@H1](C(=O)N=C3C=CN(CCO)[NH1]3)CC2)C1 O=C(C1=CN=C2C=CC(Br)=CN12)N3C[C@H1]4[C@@H1](C3)N4C(=O)NC5=CC=CC=C5 CC=1C=C(C(=O)N2CCC[C@](F)(CNC(=O)CC3=NON=C3C)C2)SC=1Cl CCC(CC)OCC(=O)N[C@H1]1CCCN(C(=O)[C@@H1]2[C@H1](CN=[N+1]=[N-1])C2(C)C)[C@@H1]1C C[C@H1]1CCC[C@@H1]1CC(=O)N[C@H1]2C[C@H1]3COC[C@@H1](C2)N3C(=O)CC(C4CC4)C5CC5 CC(C)[C@@H1](CNC(=O)C[C@H1]1OCCOC1(C)C)NC(=O)C=2C=NC3=NC=CN3C=2 CO[C@]1(C(=O)N(C)CC(=O)N2CCN(C(=O)[C@@H1](O)CC(C)(C)C)CC2)CCSC1 O=C(NC[C@@H1](O)C(=O)OCC1CCCC1)C2=CN=C(O)C3=CN=CC=C23 CCCCC(=O)N1CCC(N(CCOC)C(=O)[C@H1]2CC2(F)F)CC1 COCC(COC)C(=O)N1CCCC2(CCN(C(=O)[C@H1]3[C@@H1](C)[C@H1]3C)CC2)C1 CC1=NOC(C(F)F)=C1C(=O)NC[C@@H1]2N(C(=O)C#CC3CC3)CCCC2(C)C C=CC[C@H1](CNC(=O)C1=C[NH1]C(=O)C2=CC=NN12)NC(=O)C[C@H1](C=C)CC CC[C@]1(NC(=O)[C@H1](C)SC(C)C)CCCN(C(=O)C2(CO)CCCC2)C1 CSCC(=O)N1CC[C@@](CNC(=O)[C@H1](C)CC2CCCC2)(C3CCOCC3)C1 COCC(=O)N(C)CC(=O)NCC1(C(=O)NC[C@@]2(C3CC3)CCCO2)CCCC1 CCCN1C=CC=C1C(=O)N2C[C@@H1](NC(=O)COCCF)C3(CC3)C2 CCN(CCF)C(=O)[C@H1]1CN(C(=O)CN2CCOCC2)CC13CC3 C[C@H1](CNC(=O)[C@@H1]1CC2=CC=CC=C21)C(=O)NCC3CC(=C4CC4)C3 CC[C@@]1(F)CCN([C@H1](C(=O)NC2=CC=CC=C2)C3=CN=C(OC)C(Br)=C3)C1 CCCN(C(=O)C1=CC=CC(F)=C1)[C@@H1](C)C(=O)N(CC)CCOCCO CC(=O)N[C@@H1](C)C(=O)N1CC[C@](F)(C2=CN(CCF)N=N2)C1 CC(C)[C@@H1](C(=O)NCCCCN(C)C(=O)[C@H1]1CC1(F)F)N2CC3=CC=CC=C3C2 COC(=O)CCCC(=O)NC1(C)CN(C(=O)[C@H1]2CC=3N=N[NH1]C=3[C@@H1](C)C2)C1 CO[C@@H1]1CN(C(=O)[C@H1](O)C2CCCC2)[C@](C)(CNC(=O)C3=CC(Cl)=CN3C)C1 C=CC1(C(=O)N(CCCNC(=O)C=2N=NN(C)C=2C)C3CC3)CCCCC1 CCN(C[C@@H1](C)NC(=O)C1=COC(SC)=C1)C(=O)[C@H1](C)OC2=CC=C(C)C=C2C CCCCCOCC(=O)NC[C@@H1]1CCC[C@H1]1NC(=O)CC=2C=NSC=2 CSC1(C(=O)N[C@@H1]2CC(=O)N(C3CN(C(=O)CC4=CC(C)=NS4)C3)C2)CCC1 CC1=CC=CC=C1[C@H1](C)CC(=O)NC2(CCO)CN(C(=O)C=3C=C(C)SC=3C)C2 O=C(NC[C@@H1]1CCN(C(=O)CC2CCSCC2)C1)[C@@H1](O)C3=CN=C[NH1]3 O=C(NC1=C(O)C=CC=C1O)[C@H1]2C[C@@H1]3C[C@@H1]3N2C(=O)[C@@H1]4C=CCC=C4C=5SC=CC=5 C[C@H1](CC1CCC1)C(=O)N2CC[C@H1](CNC(=O)CC3OCCCO3)[C@H1](O)C2 N#CC1=CC=C(NC(=O)COC(=O)C2=NC(C(F)(F)F)=NO2)C(C#N)=C1 CC1=NN=CC=C1C(=O)NC[C@H1](CC2=CC=CC=C2)NC(=O)[C@H1]3CCC[C@@H1]3C C#CCOCCC(=O)NCCCC[C@@H1](C)NC(=O)C1=CC=NN1COC CCOC1=CC=CC=C1C(=O)N2C[C@@H1]3C[C@H1](C2)CN3C(=O)CC4=CC=CO4 CC[C@@](C)(OC)C(=O)N(C)C[C@H1]1CCCN1C(=O)C2=CN=CC=3C=CSC2=3 COC1(C(=O)N(C)C[C@H1]2CCCN(C(=O)CC[C@@H1]3CCCC(=O)N3)C2)CCCC1 CC1CCC(=CC(=O)N2CC3(CCC3)C[C@H1]2C(=O)N[C@H1](C)CCC(C)(C)C)CC1 CN(C)C(C)(C)C(=O)N1CC(NC(=O)C2=CC([N+1](=O)[O-1])=CC=C2Br)C1 CC1=CC=CC=2C=C(C(=O)N3C[C@H1](CNC(=O)C=4C=C[NH1]N=4)CC35CCC5)[NH1]C1=2 C[C@@H1](C(=O)N[C@H1]1CCC[C@@H1](NC(=O)C=CC2=CN=CN=C2O)C1)C(F)F CC1(C)CCN(CC(=O)N[C@H1]2C[C@H1](NC(=O)C3=CC=CN=C3S)C24CCC4)C1 CCCS(=O)(=O)[C@H1](C)C(=O)N[C@H1](CO)CCCCNC(=O)C1=CSC(C#N)=C1 CO[C@@H1](CNC(=O)C=CC=1SC=CC=1C)CNC(=O)C=2SC=CC=2NS(C)(=O)=O CSC1=NC=C(C#N)C(N2CC(CO)(NC(=O)C3=C(Cl)C=CC(Cl)=C3F)C2)=N1 CO[C@@H1]1CN(C(=O)[C@@H1](F)CCC(C)(C)C)CC[C@@H1]1NC(=O)CCC2=NN=CN2C O=C(CC1=CC=CC=C1Cl)N[C@@H1]2CN(CC3=CC=C(O)C=C3F)C[C@H1]2O O=C(CCN1C=CN=N1)NC[C@H1]2C[C@@H1](C(=O)NCC[C@@H1]3CCCO3)CO2 CC[C@@H1]1CN(C(=O)[C@@H1]2C[C@H1]2C3=CC=CC=N3)CC[C@@H1]1NC(=O)CCC(F)F COC1=C(C(=O)N2CC(F)(C(=O)NC3=CC=C4OC=CC4=C3)C2)C=CC(F)=C1F O=C1CC(C(=O)NC[C@@H1]2CCN(C3=CC(O)=NC=N3)C2)=CC=N1 CCC=1C=NOC=1C(=O)N2C[C@H1](NC(=O)CCOC(C)C)CC(C)(C)C2 CC(C)N(C)CC(=O)N[C@@H1](C)C1(O)CN(C(=O)C=CC2=CC=C([C@H1]3C[C@H1]3C)O2)C1 C#CCCC[C@@H1](C)C(=O)NCC=1C=COC=1C(=O)NC[C@@H1](O)C2=CC=CO2 CC1(NC(=O)C2=COC(CC3CC3)=N2)CN(C(=O)CCC(=O)C4=CC=NC=C4)C1 C[C@H1]1CN(C(=O)CC2(NC(=O)C3=CC=NN=C3)CCC2)C[C@H1]1F CN1N=NC2=C(C(=O)N3C[C@H1]4C[C@]4(CNC(=O)CCCS(C)(=O)=O)C3)C=CC=C21 C[C@H1](CCNC(=O)CN1C=CC=C([N+1](=O)[O-1])C1=O)NC(=O)[C@H1]2CC3(CC3)CO2 CCC1=CC([C@@H1](NCCC2=CC=CC=C2)C3=NN=NN3CCC4CC4)=CC=C1C CC1=CC=C(C(=O)N[C@H1](CNC(=O)[C@]2(C)CC[C@@H1](C(C)(C)C)CC2)C(C)(C)C)O1 CCC1=CC(F)=C(C(=O)N[C@H1](CC)CNC(=O)C=2C(Cl)=NN(C)C=2Cl)C(F)=C1 O=S1(=O)CCN(S(=O)(=O)C=2C=NN3C=CC(=NC[C@@H1]4CC4(F)F)[NH1]C=23)CC1 CC1=NN=C(CNC(=O)CN(CC(C)C)C(=O)[C@@H1]2CCSC2)S1 O=C([C@@H1]1C=CCS1)N2CCC(C(=O)N(C3CCC3)C4CCC4)CC2 CC1=CC=C(CNC(=O)[C@@H1]2CCC[C@@]23CCN(CC4=CC=C(Br)[NH1]4)C3)C=C1C CCC1=CN2C(=N1)C[C@H1](C(=O)N[C@@H1]3CN(C(=O)[C@H1](C)C4CC4)CC5(CC5)C3)CC2 CO[C@@H1](C(=O)NC(C)(C)C(C)(C)C)C1CN(C(=O)[C@H1]2C[C@@H1]2[N+1](=O)[O-1])C1 O=C(N[C@@H1]1CN(C(=O)CC2=CN=CO2)CC[C@H1]1CO)[C@@H1]3CCCS3(=O)=O CC[C@](C)(OC)C(=O)N1[C@H1]2CC[C@@H1]1C[C@@H1](CNC(=O)C3=N[NH1]C4=C3CCOC4)C2 C=C1CCC(C(=O)N[C@@H1]2CN(C(=O)CC3=NN=CN3C)C[C@@H1]2F)CC1 C[C@@H1](CN(C)C(=O)CN1C=NN=C1)NC2=NC=NC3=C2N=NN3C4CC4 O=C(NC[C@H1]1CCCCN1S(=O)(=O)C2=CC=C(Br)C(CO)=C2)C3=CN=CC=C3Br C#CCC1(C(=O)NC[C@H1](C)N(C)C(=O)[C@H1](F)CC2=CC=CC=C2)CC1 CCC(CC)N1C[C@@H1](C(=O)N(C)C[C@H1](O)CNC(=O)C2(F)CCC2)CC1=O C=C(C)CCC(=O)NC[C@H1](C)N(C)C(=O)CC1=CC(C)=NO1 CCC=CC(=O)N1CC(=O)NC[C@H1]1C(=O)NC[C@@H1](C)CC(=O)NC COC1=CC(Cl)=CC(CN2CCN(C(=O)C3=CCCCO3)[C@@H1](C#N)C2)=C1OC O=C(CC1CC(F)C1)N2CC=C(CNC(=O)C(F)(F)[C@H1](O)C3=CC=CC=C3)CC2 N#CC1=CC=C(C(=O)N2CC=C[C@@H1](C(=O)NC3=CC=CC4=C3OCO4)C2)C=C1 O=C(NC1=CC(O)=NC(Cl)=C1)[C@H1]2CN(C(=O)C3=CC=CC4=C3CCCO4)CCS2 C=CCC1(NC(=O)C2=CC=C[NH1]2)CN(C(=O)CC3=CN(C)N=N3)C1 C[C@@H1](OC(C)(C)C)C(=O)N1CC[C@H1]2[C@@H1]1CCCN2C(=O)CC3CC3 COC[C@@]1(C)CCN(C(=O)[C@H1](NC(=O)CC2CCCCCC2)C3=CC=CN=C3)C1 CCO[C@H1](CC)C(=O)NCCC1(O)CN(C(=O)[C@@H1]2CNC(=O)C[C@]23CCOC3)C1 CC(C)C1=CC=CC(C(=O)N2CCN(C(=O)[C@@H1]3CCC[C@@H1](C)C3)C[C@H1]2C)=C1F CC1=C[NH1]C(C(=O)N[C@@]2(C(=O)N[C@H1](C)C3=NN=CS3)CC2(C)C)=C1 C#C[C@@]1(C(=O)NC2=CC=C(C)C(C)=C2)CCN(C(=O)[C@H1](F)C3CCCCC3)C1 CC(=O)NCC(=O)NCC(=O)N[C@H1]1CCN(C(=O)C2=CC(C)=CN=C2C)C[C@@H1]1O C[C@@H1](CNC(=O)CCC1=CC=CC=N1)CNC(=O)C(C)(C)S(=O)(=O)C2CC2 CC(C)CC(=O)N[C@H1](C)[C@@H1](NC(=O)C=1SC=C2C=1OCCO2)C3CCCCC3 CC[C@@H1](O)[C@H1](C)C(=O)N[C@@H1](C)CC1CCN(C(=O)C2=CC(F)=CN=C2O)CC1 COC1=CC=C(CC(=O)C(=O)NC[C@H1](C2CC2)N(C)C(=O)C3=NS[NH1]C3=O)C=C1 CSCC(=O)NC[C@@H1]1C[C@@H1](O)[C@H1](NC(=O)C2(C3=CC=C(Cl)C(Cl)=C3)CCCC2)C1 CCC(=O)N1CCC[C@H1]1CN(C)C(=O)C[C@@H1](NC(=O)OC(C)(C)C)C2CC2 CC[C@H1](C)[C@H1](O)C(=O)N1CC[C@@H1]2CCN(C(=O)C3=CCCCC3)[C@@H1]2C1 CCC1=CC=C(CC(=O)N(C)[C@H1]2CC[C@H1](NC(=O)C3=CN=C(Cl)[NH1]3)C2)C=C1F O=C(NC[C@@H1]1CC[C@H1]1NC(=O)C2=CC(=O)C=C(Cl)[NH1]2)C3=CC=CC=N3 CCCCN1N=NN=C1[C@@H1](NCC2=CC=C3C=NC=CC3=C2)C4(C#N)CCCC4 CCCCCC(=O)NC[C@H1]1C[C@H1](OC)CN1C(=O)C2=CC(COC)=CC=N2 C=CC(C)(C)CC(=O)N1[C@@H1]2CN(C(=O)[C@H1](CC)C3CCOCC3)C[C@@H1]2C[C@H1]1C CC1=N[NH1]C=C1C(=O)NC[C@@]23CC[C@@H1]2CCN3C(=O)C4=CSC(C5=CN=C[NH1]5)=N4 COC[C@@H1](C)C(=O)N1CC[C@](C)(NC(=O)CN2SC(=O)C3=CC=CC=C32)C1 C[C@H1](NC(=O)C1=CC=CO1)C(=O)N(C)[C@H1](C)CCNC(=O)C2=COC3=C2COC3 CCOC1=CC(C(=O)N2C[C@@H1]3C[C@H1]2CN3CC=4C=C[NH1]C=4)=CC=C1OC O=C1C[C@@H1](CC(=O)N2CCCC[C@@H1]2CCCNC(=O)C=CC=3C=CSC=3)CN1 CC[C@@H1](O)CNC(=O)CCN(C(=O)[C@@H1]1C[C@@H1](F)C(=O)N1)C2CC2 CC1=CN=C(C(=O)N[C@@H1]2C[C@@H1](NC(=O)CC3=CON=C3C)C[C@H1]2O)N=C1 O=C(N[C@@H1]1CCCC[C@@H1]1C(=O)NC[C@@H1](O)C(F)(F)F)C2=CC=CC=C2I O=C(N[C@H1]1C[C@H1](CN2C=NC=N2)C1)C3(C4CCC4)CCC3 COC1=CC=CC(C(=O)N2C[C@@H1]3C[C@@H1](NC(=O)[C@H1](C)C=4C=CSC=4)[C@H1]2C3)=C1C O=C(CC1CCC2(CC1)CC2)NC[C@H1]3CCN(C(=O)CCC4=CSC=N4)C35CC5 CC1=CC=C(C(=O)N[C@]2(C)CCN(C(=O)[C@@H1]3CCS[C@@H1](C)C3)C2)C(N)=C1 CC1=CC=C(C(=O)NCC2(O)CC(NC(=O)[C@H1](C)OC(C)(C)C)C2)C=N1 COC1=NC(C)=CC=C1C(=O)N2CC(CNC(=O)C3=CN(C)C(=O)N=C3O)C2 CCCC[C@H1](CC)CC(=O)NC12CC(CNC(=O)C[C@@H1](C)C(C)C)(C1)OC2(C)C CC1=CC(CC(=O)NC2CC3(C2)C[C@H1]3NC(=O)C4=CC=NC=C4)=C(C)S1 CN(C[C@@H1](O)CNC(=O)CN1CCCNS1(=O)=O)C(=O)CN2C=CC=N2 CN1CCC(=CC(=O)NCCC2CN(C(=O)[C@H1]3C[C@H1]4C=CC[C@H1](C4)C3)C2)C1 C[C@H1](NC(=O)C1=CC=NS1)C2CCN(C(=O)CN(C)C(=O)C3=CC=CC=C3)CC2 CC(=O)NC1=CC=CC(C(=O)N2C[C@H1](NC(=O)C3=CSC(Br)=N3)[C@H1](F)C2)=N1 CC1=NSC=C1C(=O)N2C[C@@H1](NC(=O)C3=NN(C)C=C3Cl)C[C@H1](C(F)(F)F)C2 C#CCO[C@@H1](C)C(=O)N1CC(N(C)C(=O)[C@H1]2CC3(CCC3)CCO2)C1 C#CC1=CN=CC(C(=O)N2CCN(C(=O)[C@@H1](C)CC(N)=O)C[C@@H1]2CCOC)=C1 C=C[C@H1](CC)CC(=O)NCCN(C(=O)C=1C=C(O)N(CC)N=1)C(C)C CN(CC(=O)NCC[C@]1(O)CCN(C(=O)[C@@]23CC[C@@](C)(CO2)C3)C1)C(N)=O C[C@H1](CCN(C)C(=O)CC1=C[NH1]N=C1O)NC(=O)C2=CC=C(Cl)C3=NC=CC=C23 C[C@@H1](C(=O)N1CCCC[C@@H1]1CCNC(=O)C2=CC=CO2)N3CCOCC3 C[C@H1](NC(=O)NCCC12CCC(CC1)CC2)[C@H1](C)S(C)(=O)=O CO[C@H1](C)[C@@H1](CC(=O)N1CC(O)(C2=CN=N[NH1]2)C1)NC(=O)[C@@H1](C)NC(=O)C3CC3 C[C@H1](CCCCNC(=O)CCC1=NN=CN1C)NC(=O)[C@H1]2CC(C(C)(C)C)=NO2 C[C@H1](CNC(=O)C1=CC(F)=CC(Cl)=C1Br)NC(=O)CC2=CC=C(O)N=C2 CC1=NC(CNC(=O)[C@@H1](F)[C@@H1]2CCN(C(=O)CCCN=[N+1]=[N-1])C2)=CO1 C[C@@H1](CC(N)=O)C(=O)NC[C@@H1]1CN(C(=O)C2CC3(CCOCC3)C2)CC(C)(C)C1 CCN1N=C(C)C=C1C(=O)NC[C@]2(O)CCN(C(=O)C=3C=NN(C(C)C)C=3C)C2 CCC[C@H1](C)[C@@H1](C)NC(=O)C1(CNC(=O)C2CS(=O)C2)CC3(CC3)C1 CO[C@]1(C(=O)N(C)C[C@@]2(O)CCN(C(=O)C3(C#N)CCCCC3)C2)CCSC1 CC1=NN(C)C(N)=C1C(=O)N[C@H1]2CCCCN(C(=O)[C@@H1](C)S(C)(=O)=O)C2 C[C@H1](C(=O)N[C@@H1]1CCC[C@H1](CC(=O)N[C@@H1]2CC23CCC3)C1)N4C=CC=C4 COC1=CC=C(C)C(C(=O)N2CCC[C@@H1](C)[C@H1]2CNC(=O)CC3=NC(C)=CS3)=C1 CN1C=C(C(=O)NC[C@H1]2C[C@@H1](CNC(=O)C3=CC(Cl)=NS3)CO2)C(C(F)(F)F)=C1 CO[C@@H1](C)C(=O)NC1CC2(CCC[C@@H1](CNC(=O)C=CC3=CC=CC=C3F)O2)C1 O=C(C[C@@H1]1CCCOC1)NCC2=NOC=C2C(=O)N[C@@H1]3COC4(CCC4)C3 C[C@@H1]1C[C@@H1](C(=O)NCC2=CN=CO2)N1C(=O)C(C)(C)CC(F)F CCOC1=CC=C(CN[C@@H1](COC)[C@@H1]2CCCOC2)C(Cl)=C1 CC1=CN=CN=C1C(=O)N[C@@H1](C)C2=NOC=C2C(=O)NCC3CCC=CCC3 C[C@@H1]1CN(C(=O)C2=CC=C3[NH1]C=CC(=O)C3=C2)CCCN1C(=O)[C@@H1]4CCC(=O)N4 CC1(CNC(=O)[C@@H1]2CC=CC3=CC=CC=C32)CC(NC(=O)C(=O)NCC4CC4)C1 CC1(C)CCO[C@@H1]1C(=O)N[C@H1]2C[C@@H1](NC(=O)C3=CC=CC(C(N)=O)=N3)C24CCC4 C=C[C@@H1](CC)CC(=O)N[C@@H1](CO)CNC(=O)CCN1CCN(C(C)C)CC1 C[C@@H1](CNC(=O)C(F)(F)C1=CN=CC=N1)N(C)C(=O)C2=CN=C(C(C)(C)CF)O2 N#CCCCCC(=O)N1CCC([C@@H1]2CCN(C(=O)C3=COC(O)=N3)C2)CC1 O=C(NCC12CCC(CC1)N2C(=O)C3=CC(O)=CC=C3)C4=CCC(F)(F)CC4 C#CC[C@]1(O)C[C@@H1](C(=O)N2CCSC[C@H1]2C(=O)N3CCC(F)(F)[C@@H1](C)C3)C1 CCCC1CC(C(=O)N2CC3(CC[C@H1]3NC(=O)C[C@@H1](O)CC4=CC=CC=C4)C2)C1 CC1=CC=CC(SCC(=O)NCCCN(C)C(=O)[C@@H1]2CCOC[C@H1]2C)=C1 CN1C=NC2=C1C[C@H1](C(=O)NC[C@H1](O)CN3CCOCC3)CC2 CC1=CC=CC=C1OCC(=O)N(C)CC2(NC(=O)C3=NC(Cl)=CS3)CC2 CCCN1CCC[C@H1]1C(=O)N(C)C[C@@H1]2CCCCN2C(=O)C=3ON=C(C)C=3C COC1(C(F)(F)C(=O)O[C@@H1](C)C2=C(F)C=CC=C2Br)CCCC1 CSCC[C@H1](O)C(=O)N1CCC2(CC1)CC(NC(=O)[C@@H1]3C[C@@H1]4CCC[C@@H1]43)C2 CC1=CC=C(C(=O)N2CCC[C@@H1]([C@H1]3CCN(C(=O)C4=CC=C(N)C=C4)C3)C2)[NH1]1 CC1=NN=C(CC(=O)N2CCC3(CCCC[C@H1]3NC(=O)CC4CSC4)CC2)O1 N#CCCC(=O)N1[C@H1]2CC[C@@H1]1[C@H1](NC(=O)C=CI)C2 CO[C@H1](CNC(=O)C1=CSC(O)=N1)CNC(=O)[C@@H1]2CCN(C)[C@@H1]2C CCC[C@H1](NC(N)=O)C(=O)N[C@H1]1CC[C@@H1](NC(=O)[C@@H1]2CCN3N=CN=C3C2)C1 CCC1=C(C(=O)N2CC[C@H1](CNC(=O)COC3CC=CC3)[C@@H1](C)C2)C=CN1C COC1=NC(Cl)=C(C(=O)N[C@H1]2CC[C@@H1](N(C)C(=O)C3=C[NH1]C=CC3=N)CC2)S1 CC(C)(C)OC(=O)N1CC[C@H1](C(=O)NC2CC3=CSC=C3C2)CC[C@H1]1C(=O)O CC1=NC=CN1CCC(=O)N2C[C@@H1]3CCC[C@]3(CNC(=O)C4=COCC4)C2 COCN1C=CC(C(=O)N[C@H1](CNC(=O)CCC(F)F)C2=CC=C(F)C=C2)=N1 CCO[C@H1]1C[C@@H1]1C(=O)N2CCN3N=CC(CNC(=O)C4=CN=CO4)=C3C2 CC[C@H1](CC(=O)N1CC[C@H1]2[C@@H1](C1)CN2C(=O)C3=CSC(C4CC4)=N3)SC CC(C)[C@H1](O)C(F)(F)C(=O)NC[C@H1]1COCCN(C(=O)C=2C=NN(CCF)C=2)C1 CCN(CC)CC(=O)N1CC[C@@H1]2OCCN(C(=O)CN3C(=O)CCCC3=O)[C@@H1]2C1 C=CCCOCC(=O)N[C@H1]1CC12CCN(C(=O)C=CC3=CC=CC=N3)CC2 COC1=NC=C(C(=O)N(C)C[C@@H1](O)CNC(=O)CCN2C(C)=CC=C2C)N=C1C CCN1C=NN=C1C(=O)N[C@H1]2COC[C@H1]2NC(=O)C3=CC(F)=CC4=NN(C)C=C34 C[C@H1]1C[C@H1](NC(=O)C[C@H1]2CCOC2)CN(C(=O)C=3N=COC=3C4CC4)C1 CN(C(=O)[C@@H1]1C=C[C@H1](NC(=O)C(C)(C)N2C=CC=N2)C1)C3CCCCC3 C#CC1=CC=CC(C(=O)N[C@@H1]2CCN(C(=O)[C@@H1](OC)C3CCC3)C24CC4)=C1F CC(C)(C)[C@H1](O)CC(=O)N[C@@H1]1C[C@@H1]2CC[C@@]1(NC(=O)C(F)=C3CCCC3)C2 CCC1=C[NH1]N=C1C(=O)N[C@@H1]2CC[C@H1]2NC(=O)[C@@H1](C)C3=CC=CO3 CCOC[C@@H1](O)CN(C)C(=O)C(C)(C)[C@H1]1CCCN(C(=O)CN2CCCC2)C1 CO[C@H1]1C[C@@H1](CCNC(=O)COCCN(C)C)N(C(=O)[C@H1](F)[C@@H1]2CCOC2)C1 CC[C@@H1](CSC)NC(=O)[C@H1](CC1CC1)NC(=O)COCC(C)C NC1=CC=C(O)C=C1C(=O)N2CC[C@H1](CNC(=O)[C@H1]3CCS(=O)(=O)C3)C24CC4 C#CCCC[C@H1](C)C(=O)N1CCN(C)[C@H1](C(=O)N(C)CC2=CC=CC=C2F)C1 CC[C@H1](CNC(=O)C1=CN=C(C2CC2)[NH1]1)N(C)C(=O)CS(N)(=O)=O CCC[C@H1](O)C(=O)N1C[C@H1]2[C@@H1](C1)N2C(=O)/C=C/C3=C[NH1]C4=CC=CC=C34 C[C@](O)(CNC(=O)COC1=CC=C(O)C=C1)CNC(=O)CN2C[C@H1]3C=C[C@H1]2C3 CCCC[C@@H1](CC)CN(C)C(=O)C12[C@@H1](NC(=O)C=CC3=CC=CO3)C4C[C@H1]1[C@H1]2C4 CC(C)N(CCCNC(=O)C1(CO)CC1)C(=O)C=CC2CCCC2 CN(C[C@H1]1COCCO1)C(=O)COCCNC(=O)C2=CC=CC(O)=N2 CO[C@H1](CC1=CC=CC=C1)C(=O)NC[C@@H1](C)NC(=O)CC2=CN=NS2 COCC1(CCNC2=CC(NCC[C@@H1]3CC(C)(C)CO3)=NC=N2)CC1 CC1=C(C)[C@](C)(C(=O)N2C[C@@H1]3C[C@]3(NC(=O)CCCOC(C)(C)C)C2)CC1 CC(C)SC[C@H1](CNC(=O)OC(C)(C)C)NCC1=CN(C2=CC=C(Cl)C=C2)N=C1 CN1C[C@H1](O)C[C@]1(C)C(=O)N2CC(C)(NC(=O)COC3=CC=C([N+1](=O)[O-1])C=C3)C2 C[C@@H1]1CN(C(=O)C2=CC(Cl)=C(Cl)N2C)C[C@@H1]1CNC(=O)[C@@H1]3CCCN(C)C3 COC[C@@H1](C)CC(=O)NC[C@@](C)(CC(C)C)NC(=O)C=C(C)C1=CC=CS1 CN1CC(C)(C)C[C@@H1]1C(=O)N2CC3(CCN(C(=O)C=4N=NN(C)N=4)CC3)C2 CC=CSC[C@@H1]1[C@@H1](C)CN1C(=O)C(=O)N2CCC3(CC2)CN(C)CCN3C4CC4 O=C(NCC1(C2(O)CCOCC2)CC1)[C@@H1]3NCCOC34CCC4 CSC1=CC=C(Cl)C(C(=O)N[C@@H1]2C[C@@H1]3CCC[C@@H1]3N2C(=O)C=C[S@@](C)=O)=C1 O=C(CCC(=O)N1C[C@H1]2CC[C@]2(C(F)(F)F)C1)C3=CC=CC=C3[N+1](=O)[O-1] C=C(C)CONC(=O)CCN(C)C(=O)C=1C=CC2=C[NH1]N=C2C=1 CN(C(=O)CNC(=O)CNC(=O)CC[C@@H1]1CCCNC1)C2CC2 CC1=CN(C2=CC=CC=N2)[NH1]C1=NC(=O)CN3C=C([C@@]4(C)CCOC4)N=N3 CC(=O)OCC(=O)NC1CC(NC(=NCC2=CN=C(C)N=C2)N[C@@H1]3CCOC3)C1 CC(=O)NCC(=O)N1CCC(C[C@H1]2COCCN2C(=O)C[C@]3(C)CCCO3)CC1 C=C1C[C@@](C)(NC(=O)[C@@H1](NC(=O)CC2CC3(CCC3)C2)C4(O)CCCCC4)C=C1 CC(C)=CCN(C)C[C@@H1]1CCN(C(=O)C2=CC(F)=C(F)C=C2Cl)C1 C#CC1=CC=C(C(=O)N2C[C@@H1](C)C[C@@H1](NC(=O)[C@H1]3C[C@@H1](OC(F)F)C3)C2)C(F)=C1 CCN1C=CC(C(=O)N[C@@H1]2CCN(C(=O)C[C@H1](C)SC)C23CCC3)=N1 C[C@@H1](C(=O)NC1=CC=CC=C1)N2CC[C@@H1](CCNC(=O)C3CC(=O)NC(=O)C3)C2 CC(C)OC1(C(=O)NCCC2CN(C(=O)C3=CC=C4C(=C3)CCCN4)C2)CCC1 CN1CCN(C(=O)[C@H1]2CN(CC3=CC(F)=CC=C3Br)CC[C@@H1]2O)CC1 CC1(C)CCC=C1C(=O)N2CCN(C(=O)C3=CC(F)=C[NH1]3)C[C@@H1]2C=4C=N[NH1]C=4 CSC1=NC=CC=C1C(=O)N(CC2=CN(C(C)C)N=N2)C3CC4(CNC4)C3 CC(C)(C#N)CCC(=O)N1CCC[C@](C)(C(=O)N2CCO[C@H1]3[C@H1](O)C[C@H1]32)C1 C#CC1(F)CCN(C(=O)[C@H1]2CC23CC(NC(=O)C=4N=COC=4C)C3)CC1 O=C([C@H1]1CC12CCC2)N3CCN(C(=O)CN4N=NC(C5CC5)=N4)C6(CCC6)C3 CC1=NC(=N)[NH1]C=C1C(=O)N2C[C@H1](NC(=O)C3(C)CCCCC3)CC[C@@H1]2C CCOC(=O)CCCNC(=O)[C@@H1](C1CC2(CCCO2)C1)N3CCSCC3(C)C COC1=CC(F)=CC(C(=O)N[C@@H1]2CCCN(C(=O)C34CC(C(C)C)(CO3)C4)C2)=C1 CC1=NC=C(C(=O)NC[C@@H1]2CN(C(=O)C=3C=CC(=O)OC=3)C[C@H1]2C)C(O)=N1 C[C@H1](C(=O)N1CCC(C)(C)[C@H1](NC(=O)C2=CC=C(CO)N=C2)C1)C(C)(C)C C[C@@H1](CN(C)C(=O)C1=CC=C(C2CCCCC2)S1)NC(=O)[C@@H1](C)O CC[C@@H1]1CCC[C@@H1]1CNC(=O)NC[C@@H1]2CCCC=3OC=CC=32 CC=1C=NN(CC(=O)NCC2(O)CC(CNC(=O)[C@@H1]3C=CCCC3)C2)C=1 O=C(C[C@H1]1C[C@H1](NCC2=NC=C[NH1]2)C1)NCC3=CC=C(Cl)C=C3 C=CCNC(=O)CC1CC2(C1)CN(C(=O)C(C)(C)CF)C2 CC(=O)N1C[C@H1](CNC(=O)C2=CC=C3SN=CC3=C2)[C@@H1](C(F)(F)F)C1 CC(=O)OCCC(=O)N1C[C@H1](O)CC[C@H1]1C(=O)NCCN(C(C)C)C2CC2 CO[C@@H1]1C=CCN([C@H1](C(=O)NCCCSC)C=2C=N[NH1]C=2)C1 C[C@@](O)(CNC(=O)C1=CC=CN=C1NC(=O)C2CCC2)C(F)(F)F O=C(N[C@]1(C2CC2)CCN(C(=O)C3(O)CC(F)(F)C3)C1)C4C[C@@H1]5CC[C@H1](C4)S5 CC=1C=C(CCC(=O)N[C@H1](C)[C@@H1]2CCN(C3=NC=NC(C(C)(C)C)=N3)C2)N(C)N=1 CC1=CN(C)N=C1C(=O)N2CCCN(C(=O)[C@@H1](C)C=3C(C)=NN(C)C=3C)C[C@@H1]2C COC1=CC=C(O)C(CN2CCC(F)(F)[C@H1](C(=O)NC3=CC=CC(F)=C3Cl)C2)=C1 CC(C)(C)C=1C=C(C(=O)N[C@](C)(CNC(=O)C2=CN=C(Cl)C=N2)C3CC3)ON=1 CC[C@H1]1CN(C(=O)C2=CC=C(CC(=O)OC)C=C2)CCN1CC=3C=N[NH1]C=3 CO[C@H1]1C[C@H1](C(=O)NC[C@@H1]2C[C@@H1](NC(=O)CCC(C)(C)C)CCO2)C[C@H1]1OC CC[C@H1](NC(=O)[C@H1]1CN(C(=O)C2CC3(CC[C@@H1]3O)C2)CCO1)C4=NC=CC=N4 CCC1=CC(C(=O)N[C@@H1](C)[C@@H1]2CN(C(=O)C3(CCOC)CC3)CCO2)=NO1 CN(CC1=CSC=N1)C(=O)C2=CCN(C(=O)C3=CC=CC(F)=C3N)C2 CC1=CC=C(C#N)C=C1C(=O)NC/C=C/CC(=O)N[C@H1](C)C2=NN=C(O)O2 C[C@H1]1CCC[C@@H1](N2N=C(C3=CC=NN3C)N=C2C4=CC=C(C(F)F)N=C4O)C1 COC1=CC=C2C(C(=O)N[C@@H1]3CCN(C(=O)CC[S@](C)=O)C[C@H1](O)C3)=C[NH1]C2=C1 CC1=NC(CC(=O)N2CCOC[C@]23COCCN(C(=O)C(C)(C)N(C)C)C3C)=CS1 C=CCN(CC(=O)OCC)C(=O)C1=CCN(C(=O)[C@H1](F)C(C)C)CC1 COCC1(NC(=O)CC2=CC=CC(SC)=C2)CN(C(=O)[C@@]3(C)C[C@]3(F)Cl)C1 C[C@@]1(C(=O)NCCN(C(=O)C2=CC([N+1](=O)[O-1])=C(Cl)C=C2Cl)C3CC3)CCC[C@@H1]1O NC1=NC=CC=C1C(=O)N2CC[C@H1](NC(=O)C3=CC=CO3)C2 CC(C)[C@H1](C)C(=O)N1CC[C@H1](CNC(=O)CSC[C@H1]2CCCCO2)C13CCC3 O=C(N[C@@H1]1CN(C(=O)C[C@@H1]2CCC(F)(F)CO2)C[C@H1]1O)C3=NC=CS3 CS[C@@H1](C(=O)NC[C@@](C)(O)CNC(=O)C=CC=1C=N[NH1]C=1)C(C)C N#CCCSCC(=O)N[C@@H1](CO)CNC(=O)C1=CC=C(CO)C=C1F CC1(C)CC=C(C(=O)NC[C@@H1]2CN(C(=O)[C@@H1]3[C@H1]4CCCCC[C@H1]43)CCCO2)CC1 C[C@@H1](CC(=O)N1CC2(C1)CN(C(=O)C=3[NH1]C=NC=3C#N)C2)C4=CC=NC=C4 C[C@H1]1C[C@]1(C)C(=O)NC2CC3(CCN(C(=O)[C@@H1]4CS(=O)(=O)CC(=O)N4)CC3)C2 CC(C)N1N=NN=C1C2(NC3=CC=C(OC[C@H1](O)CF)C=C3)CC(C)(C#N)C2 CC1=NC(C(C)C)=CC=C1C(=O)NC[C@@H1](O)CCNC(=O)COC[C@@H1]2CCOC2 C=C[C@H1](C)ONC(=O)CC[C@H1]1CCCCN1C(=O)[C@@H1](CCC)N(C)C CC(C)=C(C)C(=O)N[C@H1](CNC(=O)CSCC=1C(C)=NOC=1C)[C@H1]2CCOC2 CC=1SC=C(C(=O)N2CC[C@H1](CNC(=O)[C@H1]3CC[C@@H1](C(N)=O)C3)C2(C)C)C=1N C#CCOC1=CC=C(C(=O)N(C)[C@H1](CNC(=O)[C@]2(C)C=CCCC2)C3CC3)C=C1 NC1=CC(C(=O)N[C@@H1]2C[C@H1]3CC[C@@H1]2[C@@H1](NC(=O)C4=C(Cl)CCOC4)C3)=CC=C1F CCCCOCCCNC(=O)C[C@@H1]1COCCN1S(=O)(=O)C2=CC(C)=CC(Br)=C2 CCCCC[C@H1](F)C(=O)N[C@@]12CCC[C@]1(F)CN(C(=O)[C@H1]3CCO[C@H1]3C)C2 COC[C@H1](O)C(=O)NCCCN(C)CCCNC(=O)[C@H1](C1CCC1)C(C)(C)C CCOC(=O)[C@@H1](OC)C(=O)NC1(CN(C)C(=O)[C@H1]2CC3=C(C)C=CC=C3O2)CC1 CC[C@@](C)(Cl)CNC(=O)CN(C)C(=O)[C@@H1](COC)N(C)C C[C@@H1]1CCC[C@H1](C(=O)N2CC[C@H1]([C@H1](C)NC(=O)[C@@H1]3CC[C@H1]([C@@H1]4CCCO4)O3)C2)C1 CC=1C=CN(C[C@@H1](C)C2=NC(C3=CN=CS3)=NN2C4=CC=NN=C4)N=1 CCCCCC(=O)NCC1CC2(C1)CN(C(=O)[C@H1]3CCCCN3CC(F)F)C2 CCCCS[C@@H1](C)C(=O)N[C@H1](CC(=O)NCCCCC(C)(C)C)C(C)(C)C CC(=O)N1CCSC[C@@H1]1CCNC(=O)C2=CC=C3C=CN(C)C3=C2 O=C(NCC1=CCN(C(=O)CCC(F)(F)F)CC1)C2=CSC(Cl)=N2 C=C[C@@H1](C)CC(=O)N[C@@H1]1CN(C(=O)C2=NC=CC=C2C)C[C@H1]1OC O=C1NCCN(S(=O)(=O)C2=CC=C(I)C=C2Cl)[C@H1]1C3=CC=CC=C3 O=C(N[C@@H1]1CCC[C@@H1]1C2CC2)C(=O)N3CCC(N4C=CC([N+1](=O)[O-1])=N4)CC3 CN1C=C(I)C=C1[C@H1](C(=O)NC(C)(C)C)NC[C@H1]CSC(=O)C=O CC1=CN=CC(CC(=O)NCC[C@@H1](C)CCNC(=O)C23CCC(C)(CC2)OC3)=C1 CCCN1N=C(C)C(C(=O)NC[C@H1]2CCC3(CN(CC4CC(C)O4)C3)O2)=C1C O=C(C[C@@H1]1CSCCO1)NCCCCCC(=O)NC[C@@H1]2CC[C@H1](O)C2 CN(C)CC[C@H1]1CCCN(C(=O)CNC(=O)C(=O)NC2=CC=CC=C2F)C1 COCCCOCCC(=O)N(C)C[C@H1](C)NC(=O)C(F)(F)C1=CC=C(F)C(F)=C1 CN1C=C([C@@H1]CC2CN(C(=O)[C@@H1]3CCO[C@]4(CCOC4)C3)C2)C5=CC=CC=C51 C[C@@H1]1C[C@@H1](C(=O)NCC2=CCN(C(=O)CCS(=O)(=O)N(C)C)CC2)[C@@H1](C)O1 CC1(C)CCC[C@@H1](C(=O)N2CC=C[C@H1]2CNC(=O)C3=CC=NC(C4=CC=CO4)=C3)C1 C[C@H1](N[C@H1](C)[C@H1]1CCCC2=CC=CC=C21)C=3C=N[NH1]C=3 O[C@@H1]1CCCC[C@@H1]1CNCC2=CN=C([C@@H1]3CCCO3)S2 C[C@@H1]1C[C@H1](C(=O)N(C)C[C@H1]2CCCN2C(=O)[C@H1]3CS(=O)(=O)CC(=O)N3)CCO1 CC(=O)OCCCC(=O)NC[C@@H1]1C[C@@H1](O)CN1C(=O)C[C@H1](C)C(C)(C)C CC(=O)N1CCC[C@@H1]1CC(=O)N2CC(F)(CNC(=O)[C@H1](O)C3=CC=C(Cl)C=C3)C2 COC1=C(CCNC(=O)C[C@@H1]2CC[C@H1](C)O2)C=CC=C1C(=O)O CC1=NOC=C1CCC(=O)N2CCN(C(=O)CC[C@@H1]3CC3(Cl)Cl)[C@@H1](CCO)C2 CC=CC(=O)N1CC[C@H1](F)C[C@@H1]1C(=O)NC[C@H1](O)[C@H1](C)O CC=1N=C(CC2CC2)OC=1C(=O)N3C[C@H1]4[C@H1](NC(=O)C5=CC=C(CO)O5)[C@H1]4C3 CCC1=CC=C(N2C=C(C(=O)N[C@@H1](C)CNC(=O)[C@H1]3CCCC4(CC4)C3)N=N2)C=C1 CCC1=NC(C)=CC=C1NC(=O)C=2OC(CNC(=O)C(C)(C)OC(C)=O)=CC=2C CCOC(=O)[C@@H1](C)N1C=C([C@@]2(C)CCCN(C(=O)C3=NOC=C3C(C)C)C2)N=N1 COC1(C(=O)N2CC[C@]2(C)CC(=O)NC34CCC(O)(CC3)CC4)CCCC1 CCS(=O)(=O)C1=CC=CC=C1C(=O)N[C@@H1]2CCN(C(=O)/C=C/C(F)(F)F)C[C@@H1]2C CC(C)(CCNC(=O)C1=CC(Cl)=CC=C1N)NC(=O)[C@@H1]2CCCC3=NC=CN32 C/C(I)=C/C(=O)NC[C@H1](C)CN(C)C(=O)C1=CN=CC(C)=N1 C#CC1=CN=CC(C(=O)N[C@H1]2CN(C(=O)[C@H1]3CC(=O)N(C(C)C)C3)CC2(C)C)=C1 O=C(NCC1=NC2=C(S1)CCN(C(=O)C=CC3=CC=C(Cl)S3)C2C4)CC=C[NH1]4 CN(C)S(=O)(=O)CC(=O)N[C@@H1]1CN(C(=O)CC2=CC=C(F)C=C2F)C3(CCC3)C1 O=C(NCC1=CSC=N1)[C@H1]2COCCN(C(=O)[C@H1]3CCCC4(CC4)C3)C2 C[C@H1](CC1OCCO1)OC(=O)C=2[NH1]C3=CC=CC=C3C=2[N+1](=O)[O-1] CC=1C=C[NH1]C=1C(=O)N2C[C@H1]3CC[C@@]2(CNC(=O)C4=NN(C)C=C4Br)C3 CCC(CC)(CC)C(=O)N[C@H1](C)CCC(=O)NC[C@@H1](SC)C1CC1 CS[C@H1](C)CC(=O)NCCO[C@@H1]1CCN(C(=O)C2=CC3=CSC=C3S2)C1 CC[C@H1](C(=O)N1CCN(C(=O)C2CC3(CC(F)C3)C2)C[C@@H1]1C)C(C)C C#CC[C@@H1](C)C(=O)N[C@@H1](CCCC)CNC(=O)C=1N=C(C)OC=1CC COC1=CC(N2C[C@@H1]3CN(C(=O)C4=CC(F)=CC5=CC=NC=C45)C[C@H1]32)=NC(C)=N1 CC1=CC(=O)N(CCC(=O)NC[C@@H1](C)CNC2=NC=NC=C2Cl)C=N1 C[C@@H1]1CC[C@H1](C(=O)N(CCCO)C2CCN(C(=O)CN3C=C(CO)N=N3)CC2)O1 CS(=O)(=O)N1CCO[C@@H1](C(=O)N2C[C@H1](O)[C@H1](NC(=O)C3=COC=N3)C2)C1 CC[C@H1](C)[C@H1](O)[C@H1](C)C(=O)N(C)[C@](C)(C(=O)N1CC[C@@H1](COC)C1)C2CC2 CC[C@H1](CNC(=O)C1=CC2=C(N=C1O)CCC2)NC(=O)[C@@H1](C)C3=CCCC3 O=C(N[C@@]1(CF)CCN(C(=O)[C@H1]2CC23CCC3)C1)C4=CC(F)=C(F)C=C4Cl C=C(Br)CN=C1C=C[NH1]C(=NC2CCN(CC(=O)NCC3CC3)CC2)[NH1]1 C[C@H1]1CCCC[C@H1]1CC(=O)NC2[C@H1]3C[C@H1]2CN(C(=O)CN(C)C4=CC=NC=C4)C3 CCC1=CC=C(C(=O)NCC[C@H1](C)NC(=O)C2=CC(O)=NC=N2)C=C1 CC(Cl)=CC(=O)N[C@@H1]1CC[C@@H1](C)N(C(=O)C2=CN=C(C3=CC=C(Cl)S3)S2)C1 COCC1(NC(=O)CC2=CN=C(C(C)(C)C)O2)CN(C(=O)[C@@H1]3CCC(=O)N3)C1 COC(=O)CC1(CC(=O)N[C@H1]2CC[C@H1]2CNC(=O)[C@H1]3CC34CC4)CCCC1 COC1=C(C(=O)N[C@@H1]2CN(C(=O)[C@@H1](C)C3CCCC3)CC24CCC4)C=NN1C CCOC[C@H1](C)C(=O)N(CC)[C@@H1]1CCCN(C(=O)C2(CC)CCC2)C1 C#CC(C)(C)C(=O)N1[C@H1]2CC[C@@H1]1[C@@H1](CO)N(C(=O)CCC3=NC(C)=CS3)C2 CN(C[C@@H1](O)CN(C)C(=O)C1(O)CCCCCC1)C(=O)C2=CC(Cl)=C(F)C=C2O CCCOCC(=O)N1CC[C@H1](C)[C@H1](NC(=O)C=2C=CC(=O)N(C)N=2)[C@@H1]1C CC1=CC(=NCCC2=NC=NN2C)[NH1]C(N[C@H1]3C[C@H1]4CCCCN4C3)=N1 C[C@H1](O)CC1C[C@@H1]2CC[C@H1](C1)N2C(=O)NC=3[NH1]C=NC4=NC(Cl)=CC=34 COC1=CN=C(C(=O)N2CC[C@@H1]2CNC(=O)C34CC(C3)C(C)(C)O4)N=C1 C=C[C@@H1](C)CC(=O)NCCOC1CN(C(=O)C[C@H1](C)C=2C=NN(C)C=2)C1 COC1=CC=CC(C(=O)N(C)CC[C@@H1](C)NC(=O)C2=CC(C)=CC(C)=N2)=C1C CO[C@H1]1C[C@@H1](CNC(=O)C2=CC=CC(O)=N2)N(C(=O)C3=CC(F)=C[NH1]3)C1 CCCCCCCCC(=O)NCC(=O)N[C@@H1](C)CC(=O)NC(C)C C=CC[C@@H1](OC)C(=O)N[C@@](C)(CC)CCNC(=O)C1=CC2=CC=CC(C)=C2O1 C=CC/C=C/CCC(=O)N(C)CCN(C)C(=O)C1=CC=CC(N2C=CN=C2O)=C1 COCC12CN(C(=O)[C@H1](C)[C@@H1](C)O)C(CNC(=O)C=3C=C(C)SC=3C)(C1)C2 CC1=CC=C(N2CCO[C@@H1]([C@@H1](C)NC(=O)C3=CC=CC(C(C)C)=C3F)C2)C=C1 O=C(NC[C@H1]1CCN(CC2=CC=CN=C2)C1)NC[C@H1]3CC34CCOCC4 CC(C)(C)C[C@@H1](O)CC(=O)NC1(C2CN(C(=O)C[C@@H1](O)C3=CC=CC=C3)C2)CC1 CCC=C(CCC)C(=O)N[C@@H1](C(=O)NCCC1CCC1)[C@H1]2CCOC2 C=CC1=CN=CC(C(=O)N2C[C@H1](NC(=O)C3=CN=NS3)CC4=CC=CC=C42)=C1 C=CC1(C(=O)N[C@H1](C)[C@@H1](CO)NC(=O)C=2C=NN(C)C=2C3=CC=CC=C3)CC1 C=CC(O)C(=O)NC(C)C1(CNC(=O)CC2=CC=C(C)S2)CC1 CC(=O)C=1C=C(C(=O)NC[C@H1](O)CNC(=O)[C@@H1]2C3C[C@@H1]4C2[C@@H1]4C3)N(C)C=1 CCCOCC(=O)N[C@@H1]1CN(C(=O)[C@@H1]2CC3CC2C3)C[C@H1]1OC CC(C)[C@@H1](CC(=O)N[C@H1]1CC[C@@H1](N=[N+1]=[N-1])CC1)NC(=O)[C@@H1]2C[C@H1]2Cl CC1=CC(C(=O)N2CCC[C@@H1]2C(C)(C)NC(=O)C=CBr)=C(C)N1C3CCOCC3 C=CCCCCC(=O)N[C@H1]1CCCN(C(=O)C2=CC=CC(NS(N)(=O)=O)=N2)[C@@H1]1C CN1N=CC=C1CNS(=O)(=O)C2=CC=CN=C2N3CCN(C4CCCC4)CC3 CNC(=O)C1=CC=C(C(=O)NC[C@@H1](NC(=O)CN2CC(C)C2)[C@@H1](C)C(C)C)C=N1 COC(=O)C[C@@H1](C)CN[C@]1(C2=NN=NN2CCCC3CC3)CCNC(=O)CC1 O=C1N[C@H1]2CC[C@H1]1CN(C(=O)C3=CCN(C(=O)C=C4CCOCC4)CC3)C2 O=C(C[C@H1]1CC12CC2)NC[C@H1]3[C@@H1]4CN(C(=O)/C=C/C5=CC(F)=C(O)C(F)=C5)C[C@H1]34 COCC(COC)C(=O)N(CCCNC(=O)[C@@H1](F)OC(F)(F)F)CC1CCCC1 O=C(CCF)NC[C@@H1]1C[C@@H1](O)CN1C(=O)C2=NC3=CC=CC=C3C=C2Br C[C@@H1](C(=O)NCC1=CC(C(=O)N2CCC[C@]2(C)C3CC3)=CS1)N4C=CN=C4 CC(C)=C(C)C(=O)N1C[C@@H1](CNC(=O)C=2SC(C#N)=CC=2Cl)CC[C@@H1]1C C[C@@H1](NC(=O)C(=O)N[C@@H1]1C[C@H1]1CC(C)C)C2=CC(Br)=CC=C2Cl CC1=CC=CC(C2=NC(C)=C(C(=O)N[C@H1](C)CN(C)C(=O)C34CC(C3)C4)S2)=C1 C#C[C@H1](CC1CC1)NC(=O)CCN(CC=C)C(=O)[C@H1]2C[C@@H1]2[C@@H1]3CCCO3 CC=1N=C[NH1]C=1C(=O)N2C[C@@H1](CNC(=O)C3=CC=NC(Cl)=C3O)C[C@H1]2C O=C(NCC[C@H1]1COCCO1)[C@H1]2C[C@@H1]2C3CN(C(=O)CCC=4C=CSC=4)C3 CC(C)(CNC(=O)[C@]1(C2=CC=CC=C2)C[C@H1](O)C1)NC(=O)C3=C[C@H1]4CC=CC[C@H1]34 C[C@H1](CCN(C)C(=O)[C@@H1]1[C@H1]2CCCO[C@H1]21)NC(=O)C3=CC=C4N=C(O)[NH1]C4=C3 CC1=CN=C(NCC2=CC=CC(CC#N)=C2)C=C1Br C[C@@]1(C(=O)N[C@H1](CNC(=O)C2=NC=C(Br)C=N2)C3CC3)CCOC1 CC[C@@H1](CNC(=O)CN1N=CC(Br)=N1)NC(=O)[C@@H1](O)C2CCCCC2 COCC(C)(C)CC(=O)N1CCC(O)(CCNC(=O)C2CC3(CC[C@@H1]3O)C2)CC1 CC(Cl)=CC(=O)NC1(CO)CCN(C(=O)C[C@H1]2OCC3=NC=CC=C32)CC1 CN1C=C(C(=O)N[C@H1]2CN(C(=O)C3(C)CC=CC3)C[C@@H1]4C[C@@H1]42)C(Cl)=N1 CC=CC=C[C@]1(C)CCN(C2=NN=C(C3=NC=NN3C)N2CC(=O)NCCO)C1 O=C(C=CC(=O)N1CCN(C(=O)C[C@@H1]2CCOC2)[C@H1](C3CCC3)C1)NC4CC4 O=C(N=C1[NH1]C(Br)=CN2C=CN=C12)N3CCC([C@@H1]4OCCC[C@H1]4O)CC3 CC=CC(=O)N[C@@H1]1CCN(C(=O)[C@@H1]2[C@H1]3CNC(=O)[C@H1]32)C[C@H1](O)C1 C=CC[C@]1(NC(=O)C2=NC=CN=C2Cl)CCN(C(=O)C3=CC4=C([NH1]3)CCC4)C1 C[C@H1](CC1=CN(C)N=N1)NC(=O)[C@]2(C#N)C[C@@H1]2C(F)(F)F O=C1C[C@@H1](CN=C2C=C(NCCN3C=NC4=CC=CN=C43)N=C(C(F)(F)F)[NH1]2)CN1 CC1(NC(=O)C2=CN=C(CNC(=O)C3=NO[C@H1]4COC[C@@H1]34)N=C2)CC1 O=C(C=1C=CC2=C[NH1]N=C2C=1)N3C[C@H1]4CCN(C(=O)C5=CSC=C5Br)[C@H1]4C3 COC1=CC=C(C(=O)N2CCC[C@H1]2CN(C)C(=O)C=CC=3SC=CC=3C)S1 CC(C)(C)CC1(NC(=O)[C@]2(NC(=O)C3=CSC(=N)[NH1]3)CCSC2)CC1 C[C@H1]1CCO[C@H1]1C(=O)NC[C@]2(CO)CCCN(C(=O)C3=CC=C(Cl)C=C3Cl)C2 CC1=NC=CC=C1C(=O)NC[C@]2(F)C[C@@H1](NC(=O)[C@H1](C)N3CCNC3=O)C2 CC(C)CNC(=O)CNC(=O)C[C@]1(C)CCN1C(=O)[C@H1]2COC[C@H1]2C(N)=O COC(=O)C1=CN=C(NC(=O)C2=CC=NC=C2I)C(Cl)=N1 CCN1N=C2C(=C1C(=O)NC3CN(C(=O)[C@H1]4C[C@@H1](C)CC(C)(C)C4)C3)CCCC2 COC[C@H1](O)C(=O)N1CC2(CC[C@@H1](CNC(=O)C=3SC(C)=CC=3C)O2)C1 CCS[C@H1](C)C(=O)N1CCC[C@@H1](N(CC2CC2)C(=O)/C=C/C3CCCCC3)C1 CN(C)[C@H1]1CC[C@H1](C(=O)NC[C@@H1]2C[C@H1]2NC(=O)C=3C=NN(C(F)(F)F)C=3)CC1 CC(C)(C)OCCCC(=O)N[C@H1](CC1=CC=NC(F)=C1)C(=O)O CC[C@H1](C)[C@H1](NS(C)(=O)=O)C(=O)NCCOCCNC(=O)CC1=NON=C1C C#CC[C@H1](CC(=O)N1CCC=2N=C[NH1]C=2C1)NC(=O)C[C@@H1]3C[C@H1](O)C3(C)C CC[C@@H1](F)C(=O)NCCCOCCNC(=O)C(C(C)C)C(C)C C#CCN(CC#CC)C(=O)CC[C@@H1](C)NC(=O)C(=O)[C@H1](C)CC O=C(CCC(F)(F)F)NC1=CC=C(C2=CC(O)=CC3=CC=CC=C23)N=C1 C#CCSCC(=O)NC1CC2(C1)CC(NC(=O)C[C@@H1]3CC(=O)C4=CC=CC=C43)C2 C[C@@H1]1C[C@@H1](C(=O)NCC2=CC=CC=C2CNC(=O)CCSC3=CC=CC=C3)CO1 CCOCC(=O)N1C[C@H1](C)CC[C@H1]1C(=O)NC[C@H1](C)C2=CN=C[NH1]2 CCC[C@H1](C)CNC(=O)[C@H1](CNC(=O)C1=CC=C(C2CC2)C=C1)C(C)C CCC[C@@H1](NC(=O)C=CC(=O)N(C)C)C1=CN(C2=CC=C(F)C=C2Br)N=N1 C[C@H1](O)[C@@H1]1C[C@@H1]1C(=O)N2CC[C@@](CF)(NC(=O)[C@H1]3CCC(C)(C)O3)C2 C[C@@H1](CCC(=O)N[C@H1]1CCC[C@H1](O)[C@@H1]1O)NC(=O)[C@H1]2C[C@H1]3C=C[C@@H1]2CC3 CCC(CC)CN(CC)C(=O)[C@H1]1CN(C(=O)C2=CC=NN2CC)CC(C)(C)C1 CN(CCN1C=CN=C1)C(=O)[C@H1](NC(=O)C[C@H1]2CCC(=O)N2)C3=CN(C)N=N3 C=C(Br)CCC(=O)NC[C@H1]1CCN1C(=O)C2=CC(C)=NC(O)=N2 COC1=NC=NC(OC)=C1C(=O)N2CCC(O)(CNC(=O)[C@@H1]3CCC3(C)C)CC2 CNC(=O)[C@H1](C)CNC(=O)C1=CC=CC2=C1C3CCC2CC3 C[C@@H1](C(=O)NC[C@H1]1CN(C(=O)C2=CC3=NC(F)=CC=C3O2)C[C@H1]1O)C(F)(F)F C[C@]12CC[C@H1]1CN(C(=O)C3(F)CN(C(=O)CN4C=C(C#N)C=N4)C3)C2 CC(=CC(C)(C)C)C(=O)N1CC(F)(F)C[C@H1]1CCNC(=O)[C@@H1](C)N2CCC2 CCO[C@@H1]1C[C@@H1]1C(=O)NC[C@H1]2[C@@H1]3C[C@H1]2CN3C(=O)C[C@H1](C)C4=CC=CC=C4F CCNC(=O)C1=CC=C(CNC(=O)C2CCC(CC2)NN=CC)C=C1 CC1=NC([C@@H1](C)NC2=CC(NCC3=CC=CC(N)=N3)=NC=N2)=CS1 C[C@H1](CC(=O)N[C@@H1]1CC[C@@H1](NC(=O)CN2CCOCC2)C1)OC3=CC=CC=C3 CC[C@@H1](CN(CC)C(=O)C1=C(C)CCC1)NC(=O)C2=CC=CC=C2N=NN(C)C O=C(C[C@H1]1CCCO1)NC[C@@H1](CO)CNC(=O)C=2[NH1]C=CC=2C3=CC=CC=C3 CCCCOCC(=O)NC[C@H1]1[C@@H1]2CN(CC3=NC(C4CCC4)=NO3)C[C@H1]12 C=C(Cl)CCC(=O)NC[C@H1]1C=C[C@@H1](NC(=O)C2=NC=NN2C)C1 O=C(CCC1=NN=CS1)N[C@H1](CO)C(=O)N[C@H1]2CCOCC23CCC3 C=CC1(C(=O)NC[C@@H1](C)NC(=O)C=2C=C3C=CC=CN3C=2)CCCCC1 O=C(NC[C@@]12CCC[C@@H1]1CCN2C(=O)CC3CC3)C4=CN=C5C=CC=CN5C4=O C=CC1(NC(=O)[C@@]2(F)CCCN(C(=O)[C@H1](CN(C)C)N(C)C)C2)CCC1 O=C(CNS(=O)(=O)C1=CC=CS1)NCCC2(NC(=O)[C@H1]3CC34CCSCC4)CC2 C[C@@](O)(C(=O)N1CC[C@H1](N2CCN(C(=O)C=3N=N[NH1]C=3Cl)CC2)C1)C(F)(F)F CO[C@@H1](C(=O)NCCCOCCN(C)C(=O)[C@H1]1CC12CCC(C)(C)CC2)C(C)C CC[C@H1](CC(=O)N(C)C[C@H1](O)CN(C)C(=O)C1(C)CC(F)C1)C(C)C COC1(C(=O)N[C@@H1]2CCCC[C@H1]2CNC(=O)[C@H1]3CCN(C)C3=O)CCCCCC1 C#CC(=O)N1CCC(F)(F)[C@@H1](C(=O)N2CCC3=C(Cl)C=C(Cl)C=C3[C@H1]2C)C1 CS[C@H1]1C[C@H1](C(=O)N(C)[C@H1]2CCCN(C(=O)COC=3C=CN(C)N=3)C2)C1 CN(CC[C@H1]1CCCO1)C(=O)[C@@H1]2CCN(C(=O)C3CC(CF)C3)O2 CCC(CC)CCCN(C)C(=O)[C@H1]1CN(C)CCN1C(=O)CCCCCC#N CC[C@H1](CNC(=O)C[C@@H1](C)[C@H1]1CCCO1)NC(=O)C2=COC(C(F)F)=C2 CCCCN(C)C1=NC(N[C@@H1](C)C2=CC(Cl)=CC=C2F)=NC3=C1C[C@@H1](C)CC3 C[C@]1(C(=O)NCCC(=O)NC2CC2)CCN(C(=O)CC[C@@H1]3CCOC3)C1 C[C@H1](CCCNC(=O)[C@@H1]1CCCOCC1)NC(=O)CCNC(=O)C2CCC2 CCC=1C=C(C(=O)NC[C@@H1]2CCC[C@@H1](NC(=O)C(F)(F)C(C)(C)O)C2)SC=1C O=CNCCC1(SCC(F)F)CCCN1 CCC1=CC(C(=O)N[C@H1]2CC23CC(NC(=O)C(F)(F)C4=CC=C(Cl)C=C4)C3)=N[NH1]1 CC=1SC=CC=1C(=O)N2[C@H1](CNC(=O)C3=COC(C(C)C)=N3)C[C@@H1]4COC[C@H1]42 COC[C@H1](O)C(=O)N1CCC(C)(CNC(=O)C2=CN=CC(F)=N2)CC1 CCCCSCC(=O)NCCC[C@H1](CCC)NC(=O)C1CCN(CC(F)F)CC1 CCC1=CC=C(C(=O)N2CC[C@H1]([C@@H1](C)C(=O)NC[C@@]3(CO)CCN(C)C3)C2)[NH1]1 CCS(=O)(=O)N[C@@H1](C)C(=O)NCC[C@H1](C)CCNC(=O)CN1CCCCCC1 CC1=CC=C(C(=O)N[C@@H1]2C[C@H1]3C[C@H1]2CN3C(=O)C(F)(F)C4=CSC(=N)[NH1]4)C=C1 CC(C)=CCC(=O)NC[C@@H1](F)C1CCN(C(=O)CNC=O)CC1 CC(C)C1=CC=CC=C1CC(=O)NC[C@@H1]2CCC[C@@H1](NC(=O)CN(C)C)C2 CC[C@@H1](C(=O)NC[C@H1]1C[C@@H1]2CC[C@H1](C1)N2C(=O)[C@]3(C)C[C@@H1](O)CN3C)C(C)C CC/C=C/CC(=O)N1CCC(F)(F)[C@@H1](NC(=O)C2=CC(C)=CC=C2I)C1 CC(=O)C1=CC=C(C(=O)NC2CCN(C(=O)C3CS(=O)(=O)C3)CC2)N=C1 C=C1C[C@@H1]1C(=O)N2C[C@H1]3C[C@H1](NC(=O)C4=NC=C([N+1](=O)[O-1])N4C)C[C@H1]3C2 COC1=N[NH1]C=C1C(=O)N2C[C@H1]3C[C@H1](O)[C@@H1]2[C@@H1]3NC(=O)C4=CC=CC(=O)N4C CCNC(=O)CNC(=O)[C@@]1(COC)C=CCN1C(=O)CNC(=O)[C@H1]2C[C@@H1]2C C[C@H1]1C[C@@H1](CO)CCN1C(=O)C23CC(CO)(CN2C(=O)[C@H1]4C[C@@H1](C)N(C)C4)C3 CC(C)N(CCCNC(=O)[C@@H1]1C[C@H1]1C2=CN=CN2C)C(=O)C=CC3CCOCC3 CC1=C(C(=O)NCCC2(O)CCN(C(=O)[C@]3(C#N)CCCOC3)CC2)C=NN1C C[C@@H1](CN(C)C(=O)[C@H1]1COCC1(C)C)C(=O)NN2N=NC3=C2CCCC3 CCC1=NC=C(Cl)C(C(=O)NCCCCNC(=O)[C@@H1](SC)C(C)C)=N1 CC=1N=C(S)SC=1CC(=O)NCC[C@H1](C)N(C)C(=O)[C@H1]2CC3=CC=C(F)C=C32 COC1=C(C(=O)N2[C@H1](C(=O)NCC[C@H1]3C[C@H1](F)C3)C[C@@H1]4C[C@@H1]42)C=NN1C COC1=CC=C([C@H1](NC(=O)N2CCC[C@@H1](C3CC3)CC2)C4CCC4)C=C1OC CC1=CC=C(F)C=C1CC(=O)N[C@H1](CO)[C@H1](C)NC(=O)[C@H1]2CCC3(CCC3)OC2 O=C(NC[C@@H1]1CC[C@H1]1NC(=O)C2=CN=C3N=CC(Cl)=CN23)C=4C=NN5C=4CCC5 C#CCCCC(=O)N[C@@H1]1CCC[C@@H1]1CNC(=O)CN2C=NC(C(F)(F)F)=N2 CC[C@H1](C(=O)NC[C@@H1]1[C@@H1](C)CCCN1C(=O)C=2C=CN3C=C(C)N=C3C=2)N(C)C CCCC1=CC(C(=O)N2[C@H1](C)[C@H1]3C[C@@H1]2[C@H1]3NC(=O)C[C@@H1]4COCCN4C)=CC=N1 CCC1=CC=NC(C(=O)NC[C@H1]2[C@H1](O)[C@H1](O)CN2C(=O)CC3CS(=O)(=O)C3)=C1 O=C(C1=CN=NC=C1O)N2CCOC3(CN(C(=O)CCC4=CC=CN=C4)C3)C2 CC(=O)NC1=NC=C(C(=O)NC[C@@]2(C)COCCN(C(=O)CCNC(N)=O)C2)O1 CC=1C=C(CNC(=O)[C@@H1](CCSC)NC(=O)[C@@H1]2CN(C)CCO2)OC=1C C[C@@H1]1CN(C(=O)[C@@H1]2CCCC[C@@H1]2C3CC3)CC[C@H1]1CNC(=O)C[C@@H1]4CC[C@@H1](O)C4 CC1=CN=C(NCCCNS(=O)(=O)CC)C(S(=O)(=O)N2CC[C@H1](N(C)C)C2)=C1 CC1=NC2=NC=CC=C2C=C1CC(=O)NCC3(C(N)=O)CN(C(=O)CN(C)C)C3 C=CCNC(=O)[C@@H1](CCCCCOC)N1C[C@H1](O)[C@@H1](OC)C1 CCN=C1C=C(C(=O)NC2(CNC(=O)CCC3=CC=CC=C3Cl)CCC2)C=C[NH1]1 C=C1CC(C)(C(=O)N[C@H1]2COC3(C2)CN(C(=O)C4=N[NH1]C=C4OC)C3)C1 CC1=N[NH1]C(C)=C1CCC(=O)NC[C@@H1]2CN(C(=O)C3(O)COC3)CCC2(F)F COC1=CC=C(C(=O)NC2([C@H1]3CCN(C(=O)CC4CC=CC4)C3)CC2)N=C1Cl CO[C@H1]1C[C@H1]2C[C@H1]1C[C@@H1]2NC(=O)N3C[C@@H1](NC(C)=O)C4(CC4)C3 COC1=C[NH1]C(C(=O)N2[C@H1]3CCC[C@H1]2CN(C(=O)C4=CN(C)[NH1]C4=N)C3)=CC1=O CC[C@@H1](C(=O)N[C@@H1]1CN(C(=O)CC2=NN=CN2C(C)C)C[C@H1]1C)C3CCOCC3 CCCC(C)(C)CC(=O)N[C@H1](C)C1(O)CN(C(=O)C2=CC=C(C(F)(F)F)[NH1]2)C1 COC1=CC(OC)=CC(C(=O)N[C@H1]2[C@@H1]3CN(C(=O)C4=NC=C(Cl)N=C4Cl)C[C@@H1]32)=C1 CO[C@@H1]1CN(C(=O)[C@H1](N2C=CN=N2)C(C)(C)C)C[C@H1]1NC(=O)C3=NN(C)C=C3N C#CCCC(=O)N1CC2(NC(=O)C=3C=NN([C@H1](C)CC)C=3C)CCC1CC2 C[C@H1](CC(=O)N1C[C@@H1]2C[C@@]2(CNC(=O)C3=CC=C(F)C=N3)C1)NC(N)=O O=C(NC[C@H1]1C=CCN1C(=O)C2=CC=C3C(=C2)CCCCC3=O)C4=CCCSC4 COCCOCCOCC(=O)N[C@H1](CNC(=O)[C@@H1](C)C1=CC=CS1)C2CC2 CO[C@@H1](C)C1=NC(C(=O)N[C@H1]2CN(C(=O)C=3C=N[NH1]C=3)CC24CCC4)=CO1 CC[C@H1](C)[C@H1](C)CN1C[C@@H1]2C[C@H1]1CN2C(=O)CC3CC3 CCC1=CC(C)=C(C(=O)N[C@@H1]2CCN(C(=O)C3CC4(C3)CC4(F)F)C2)O1 COC1=CN=C(CNC(=O)[C@H1](CCF)NC(=O)C2=NC=C(F)C=C2C)C=N1 CN(CCNC(=O)[C@@H1]1COC(=O)N1)C(=O)C2=CC=C(CN3CCC(O)CC3)C=C2 CO[C@@H1](C(=O)N1C[C@@H1]2[C@H1](C1)[C@@H1]2NC(=O)C3=NC=C(Cl)C=C3Cl)C4=CC=CC=C4Cl CC[C@H1](C)[C@H1](C(=O)NC1CC2(CSC2)C1)N(C)C(=O)CCC3=CN=CS3 CCOC(=O)C1=CN=C(N(C)C[C@H1](O)CN(C)C(=O)[C@H1](F)OC)N=C1C O=C(NCCCNC(=O)C1(CC2CC2)CCC1)[C@@H1]3CCC4(CCC4)C3 COC1=NC(C(=O)N2CC[C@@H1](CC(=O)N3CC=4N=C(C)SC=4C3)C2)=CC=C1Br COC1=NC=C(C(=O)N2[C@H1]3CCC[C@H1]2CN(C(=O)[C@@H1]4C[C@H1]4[N+1](=O)[O-1])C3)C=N1 CS[C@H1](C)CCC(=O)NCCCCCNC(=O)C1=CC(C2(C)CC2)=N[NH1]1 O=C(O)CC1=NC2=C([NH1]1)CN(C(=O)[C@@H1]3CO[C@@H1](CN4C=CC=N4)C3)CC2 CCOCCC(=O)N(C)CC[C@H1](C)NC(=O)CC1=CC=C(S(=O)(=O)NC)C=C1 CNC(=O)COCC(=O)NC1CC(N2C=C(CN3CCSCC3)N=N2)C1 CC(C)N1C=CC(CNC(=O)CC2(N(C)C(=O)[C@@]3(C#N)C[C@H1]3C)CC2)=N1 CN(CC(=O)N(CCO)CCCNC(=O)[C@@H1](O)CC1=CN=C[NH1]1)S(C)(=O)=O C[C@H1]1OC(=O)N[C@H1]1C(=O)N2CC=C(CNC(=O)C3=CC=[N+1]([O-1])C=C3)CC2 CC1=CSC(CCC(=O)NC[C@@H1]2C[C@H1]2NC(=O)/C=C/C3=CC=C(Cl)C=C3F)=N1 O=C(NCC1=CC=CC=C1OCC(F)(F)F)NC[C@]23CCCC[C@H1]2C3 CCC(CC)CCC(=O)N1CC[C@@H1](NC(=O)CCCCC(N)=O)C12CCC2 CC=1N=C(C)N(CCC(=O)N[C@H1]2CCN(C(=O)[C@@]3(C)CCCCO3)[C@H1](C)C2)N=1 C[C@H1](CC(=O)NCC=1C=C(C(=O)N(C)CCC2CCC2)ON=1)CC(C)(C)C CC1=NC=CN=C1[C@H1](C)NC(=O)[C@H1]2CC(=O)CN2C(=O)C(F)(F)C3CC3 CC1=NOC(C)=C1[C@@H1](C)CC(=O)N(C)C2CN(C(=O)[C@@H1]3CCCSS3)C2 CCC(=CC(=O)NCC[C@]1(C)CCO1)C2=CC=C(C)C=C2 CC1=CN(C)[NH1]C1=NC(=O)C2=CON=C2[C@H1]3CCCN3 CC[S@](=O)CC(=O)NC[C@H1]1CC12CCN(C(=O)C3=CN(C4CC4)C=N3)CC2 C[C@@H1](OCCN(C)C)C(=O)NC1CC(C2CCN(C(=O)[C@@H1]3CNC(=O)N3)CC2)C1 COC1=CC=C2C=CC=NC2=C1C(=O)N[C@H1](CO)CNC(=O)C[C@H1](C)F C[C@@H1]1[C@H1](N(C)C)CCN1C(=O)C2(F)CCN(C(=O)C3=CN=C(Cl)S3)CC2 O=C(C1=CC=C(C2(O)COC2)C=C1)N3CCN(C(=O)N4CCCCC4)CC3 C[C@@H1]1CCN(CC(=O)NCC2=NC(C(=O)NCCC3=CC=C(O)C=N3)=CO2)C1 CCN1N=CC(Cl)=C1C(=O)NC[C@]23C[C@@H1]2CN(C(=O)CCC4=CC(C)=NO4)C3 CC1(C)CC[C@H1](C(=O)N2CC[C@@H1](CO)[C@H1](NC(=O)C=3SC=C4C=3OCCO4)C2)O1 CCC1=NC=CC=C1C(=O)NC2=NC=C(C3=CCCC3)C=N2 C[C@H1]1CN(C(=O)[C@H1]2CNC(=O)N2C)C[C@H1]1NC(=O)[C@H1](O)CCC3=CC=CC=C3 O=C(NC1(CO)CCN(C(=O)[C@@H1]2COCC3=CC=CC=C32)CC1)C4=CSC=N4 COCCOC1=CC=CC(CN(C=O)C2CC(C(F)F)C2)=C1 CC(C(=O)N1CCO[C@H1](CN(C)C(=O)[C@H1](C)/C=C/C2=CC=CC=C2)C1)=C3CCC3 CC1=NC(C2CC2)=CC=C1C(=O)NC(C)(C)[C@H1]3CCN(C(=O)[C@H1](C)C#N)C3 CC(C)(C)[C@@H1](O)C(=O)NC[C@@H1]1CCCCCN1C(=O)CCC2CC(F)(F)C2 CN1CCC(C(=O)N2C[C@@H1]3C[C@H1]2[C@@H1]3CNC(=O)[C@@H1]4CC5(CCCC5)CO4)CC1 CC(C)C=1C=C(C(=O)NCCC2(O)CCN(C(=O)CCC3CCC3)CC2)ON=1 CCC[C@H1](F)C(=O)NC[C@](C)(O)CNC(=O)[C@H1](F)C1CCC1 CCOC1=NC(C(=O)N2CCO[C@@H1](C)[C@@H1]2C(=O)N(CC)C[C@@H1]3CCCO3)=CO1 COC(C)(C)C(=O)N[C@H1]1C[C@]2(C(=O)NC[C@H1](C)C3=CC=NC=C3)CO[C@H1]1C2 CC=1[NH1]N=C(C(=O)N[C@@H1]2C[C@@H1](CC(=O)N[C@H1]3CCNC3=O)C2(C)C)C=1O CC[C@H1](C)N1N=C(C=2C=CSC=2)N=C1C3=CN=C4N3C[C@H1](C(F)(F)F)CC4 O=C(NC[C@H1]1C[C@H1](O)[C@H1](O)C[C@H1]1C(=O)N(CCO)C2CCC2)[C@@H1](F)[C@@H1]3CCOC3 CC(C)NC(=O)CN(C)CC(=O)NC[C@H1](C1CC1)N(C)C(=O)C2C[C@H1]3C[C@@H1]3C2 CCC1=NN=C(CNC(=O)C(C)(C)[C@H1]2CCCN(C(=O)[C@H1]3CC[C@H1]4C[C@H1]43)C2)O1 CCOC1=CC=CC=C1CCC(=O)N[C@@H1](CNC(=O)C[C@@H1](C)SC)CC(F)(F)F COC=1C=C(CN(C)C2=NC(N(C)CCOC3CC3)=C4N=CC=CC4=N2)SN=1 COCC(COC)C(=O)NCC=1C=C(C(=O)NCC[C@@H1](O)C(F)F)N(C)N=1 COC(=O)C1(CN2CCC[C@@]3(CC=CCC3)C2)CC(C)C1 CO[C@H1]1C[C@H1](NC(=O)CCC(C)(C)C)CN(C(=O)[C@@]23CC[C@@](F)(CO2)C3)C1 CC1=CC=C(Cl)C(C(=O)NCCCN(C)CCCNC(=O)CS(C)(=O)=O)=C1 CN1CCC(CC(=O)N[C@H1]2CN(C(=O)C(Cl)(Cl)Cl)CCC2(F)F)CC1 COC1=CC=CC=C1[C@@H1](C)CC(=O)N[C@H1](CO)CNC(=O)C2=CC(C)=CC=C2N C#CC1=CC=C(CCC(=O)NC[C@H1](O)CNC(=O)[C@@H1]2CC3=NN=C(C)N3C2)C=C1 C[C@@H1]1CN(C(=O)C2=CC=NN=C2N[C@@H1]3CC3(C)C)C[C@H1]1N4C=C(C(C)(C)O)N=N4 O=C(COCCOCCO)NC1=CC=C(N2CCOCC2)N=C1 CC1=NO[C@H1](C(=O)NC2(C(=O)N(C)[C@H1]3C[C@H1](CO)C34CCC4)CSC2)C1 CCN(CCCNC(=O)C1=CN2C=CC=C(N)C2=N1)C(=O)[C@@H1]3CCCC(C)(C)C3 CC1=NC(C(=O)N2CC[C@H1]3CCC[C@@]32CNC(=O)CC=4SC(O)=NC=4O)=NN1C C=CC[C@H1](CC)C(=O)N[C@H1]1C[C@H1]2CC[C@]1(C(=O)NOC[C@H1](C)CC)C2 CC1(CNC(=O)CSC2=CC=NC=C2)CC(NC(=O)CC3(C#N)CCOCC3)C1 COC(=O)C1=CC=CC(C(=O)N(C)CC(C)(C)CNC(=O)[C@H1]2C[C@H1]2C(N)=O)=C1C O=C(NC[C@H1]1CCCN(C(=O)C2CC3(CCO3)C2)C1)[C@@H1]4CCC5=NN=C(O)N5C4 CC1=CC(C#N)=C[NH1]C1=NC(=O)C(=O)N2CCC(O)(C3(C(=O)O)CCC3)CC2 C[C@@H1]1CCN(C(=O)C[C@@H1]2CC3CCC2CC3)[C@@H1]1CNC(=O)CC[C@H1]4CC[C@@H1](C)O4 CS(=O)(=O)C1=NC=C(C(=O)NC2CCCN(CC3=CC=C(F)C(Br)=C3)CCC2)S1 C[C@H1]1COC[C@H1]1N=C2[NH1]C=NCC(=O)N(C)C=C2 CC1=CC(OCC(=O)N[C@@H1]2CC23CCN(C(=O)[C@H1](C)CF)CC3)=CC(C)=C1Cl CC=1N=C(O)[NH1]C=1C(=O)N[C@@H1](C)[C@H1]2CN(C(=O)CC34COC(C)(C3)C4)CCO2 CC1=CC(C(=O)N2CCN(C(=O)C3=NSC4=CC=CC=C34)C[C@@H1]2C)=CC(C)=C1O CCOC(=O)CCC(=O)N1[C@H1]2CC[C@@H1]1[C@@H1](CO)N(C(=O)CCNC(N)=O)C2 C[C@@H1](C(=O)NCCCOCCNC(=O)[C@H1](C)CC(N)=O)C(F)(F)C(F)F C[C@H1](OCCN(C)C)C(=O)N[C@H1]1CCCN(C(=O)C2=CC3=C(C=C2O)OCO3)C1 NCCCC[C@H1](CCC(F)(F)F)C(=O)N1C[C@H1]2CCCC[C@H1]2C1 CC[C@@H1](SC)C(=O)N1CCO[C@@H1](C(=O)NCCCCC2CC2)CC1 CN1C[C@@H1](F)C[C@H1]1C(=O)NCCC(=O)NCCCC[C@H1]2C[C@H1]2C N#CC1=CC=CC(C(=O)NCCO[C@@H1]2CCN(C(=O)[C@@H1]3CCNC(=O)C3)C2)=C1 COC1=NC=CC=C1NC(=O)[C@H1](CC2CCOCC2)NC(=O)C=3N=CSC=3C CC1=CC=C2C(=C1)C[C@H1](C(=O)NCC[C@H1](C)N=C3[NH1]N=C(C(C)(C)C)O3)S2 CC[C@]1(O)CCN([C@@H1](C)C(=O)NNC(=O)C2=CC=C(C)O2)C1 O=C(C1C=CC=CC=C1)N2CC[C@H1](NS(=O)(=O)C3=CC=C4C(=C3)CCC4)C2 CN(CC(=O)NCC[C@](CNC(=O)C1(F)CC1)(C(C)(C)C)C)C(=O)C2CC2 O=C(N[C@@H1]1C[C@H1]2C[C@@H1](C1)N(C(=O)C=3C=N[NH1]C=3)C2)C4=CC=C5N=C[NH1]C5=C4 CCCC[C@H1](CC)C(=O)N[C@H1](CCC)CCCNC(=O)CNS(N)(=O)=O CC1=NC(C)=C(C(=O)N[C@@H1](C)C2CN(C(=O)C3=CC=CC4=C3C(=O)NC4=O)C2)[NH1]1 CCN1CC[C@H1](N(C)C(=O)[C@]2(CC)CCN(C(=O)[C@@H1]3CCO[C@@H1]3C(C)C)C2)C1 CCC1=CN=C(C(=O)N2C[C@@H1](NC(=O)[C@@H1]3CNC(=O)N3)CC[C@@H1](O)C2)C=N1 C#CCCC[C@@H1](C)C(=O)OCCN1N=CC2=CC=CC=C21 CCOC(=O)C1=CN2C(=N1)CN(C(=O)[C@@H1](C3CC3)N(C)C(=O)C4=COC=N4)CC2 COCCCC1CCN(C2=CC(C)=NC(N(C)C[C@]3(C)CCCO3)=N2)CC1 CC1=NC(O)=CC(C(=O)N2CC[C@](O)(CCNC(=O)[C@H1](NC(N)=O)C(C)C)C2)=N1 C[C@H1]1C[C@H1]1CCCCOC(=O)C=2C=NN3C=2N(C(=O)OC(C)(C)C)CC3 COCC[S@@](=O)CCNC1(C2=NN=NN2CCCSC)CCS(=NC(C)(C)C)CC1 C[C@@H1](CNC(=O)/C=C/C1=CN=CC(O)=C1)NC(=O)CCCC2=CC=C(Cl)C=C2 CC1(C)CC=C(C(=O)NC[C@]2(F)CCCN(C(=O)CC3CC(F)C3)CC2)CC1 C[C@]1(F)CN(C(=O)C2=CC3=CC=C(O)C=C3[NH1]2)CCN(C(=O)[C@@H1]4CCC4(F)F)C1 C/C=C/C[C@@H1](CC)C(=O)N[C@H1]1C[C@@H1](CNC(=O)[C@](O)(C(C)C)C(F)(F)F)C1 CN1C=C([C@@H1](O)C(=O)NC[C@@H1]2CC(C)(C)CN2C(=O)C3=CSC=N3)C=N1 O=C(N[C@@H1]1CCC=2ON=C(C(=O)NC[C@]34CCC[C@H1]3C4)C=2C1)C56CC(CO)(C5)C6 COCC(=O)N[C@H1](C)C(=O)N1C[C@@H1]2C[C@H1](NC(=O)C3=NC=NC=4SC=CC3=4)[C@H1]1C2 CC=1C=C(C)N2N=CC(C(=O)N3C[C@@H1]4CN(CC5=CC(Br)=C(C)S5)C[C@H1]4C3)=C2N=1 CC1=C([C@H1](C)NC(=O)[C@H1]2CC3(CCOCC3)CO2)C=NN1C C#C[C@@H1](C)OC(=O)[C@H1](CC1=CC=CC=C1F)N(C)C CC=1C=C(C=CC(=O)NC2(C/C=C/C(=O)NC3=CC=C(C)C(CO)=C3)CC2)ON=1 C[C@H1]1CC[C@H1](C(=O)NC2CC(CC(C)(C)C)C2)N(C(=O)C3=CC=CO3)C1 FC1CCN(C2=NC3=C(C(=NCC4=CC=C(C(F)(F)F)N=C4)[NH1]2)CSC3)CC1 NC(=O)C[C@@H1](O)C(=O)N1CCN(C(=O)CCN2C=CN=N2)[C@H1](C3CCC3)C1 CNC(=O)[C@H1]1CCN(C(=O)C(=O)N[C@H1]2CCC3=NC(=N)[NH1]C=C3C2)[C@@H1]1C CCSC[C@H1](CO)NCC1=CC=CC=C1O[C@@H1](C)CC O=C([C@@H1]1CO[C@@H1]2COC[C@@H1]21)N3CC4(C3)CN(C(=O)C5CC6(C5)CC67CC7)C[C@H1]4CO CC(C)CCC(=O)N[C@@H1](C)C1(O)CN(C(=O)C2=CC=CC=3C=CN(C)C2=3)C1 COCCC(=O)N1C[C@H1]2[C@@H1]([C@H1]1C(=O)N3CCC4=NC=CC=C4C3)C2(C)C O=C(N[C@H1]1C[C@H1](CO)C12CCC2)[C@@H1]3CCCN(C(=O)CC4(O)CCCC4)C3 CN(C)S(=O)(=O)CC(=O)N1CC(N2CCN(C(=O)[C@H1]3COCC3(C)C)CC2)C1 CC(C)(CC[C@@H1](NCC1=NC(C(C)(C)C)=NS1)C2=CC=CS2)C(F)F CSCCCCC(=O)N1CC[C@@](CO)(C(=O)NCC2CCC(C)CC2)C1 N#CC1[C@H1]2CC[C@H1]1CN(S(=O)(=O)C3=CC=C(N4CCCC[C@@H1]4CC(N)=O)N=C3)C2 CCN(CC)C(=O)CCC(=O)N[C@H1]1C[C@@H1](CNC2=CC(=O)N3C=CC=CC3=N2)C1 CC=C(F)C(=O)N1CCC[C@H1](NC(=O)C2(COC)CCC2)[C@@H1]1CC CCNC(=O)C(=O)N1CCC[C@@H1]1[C@@H1](O)C(=O)NC[C@@](C)(O)CCOC COC[C@@H1](C(=O)N[C@@H1]1CC12CC(NC(=O)CCC3=CC=C(Cl)C=C3F)C2)N(C)C CCC(CC)OCC(=O)N[C@@H1]1CCN(C(=O)/C=C/C(C)(C)C)C[C@H1](O)C1 COC1=CC(C(=O)N2CCCC[C@@H1]2C(=O)N3CCOC[C@@H1](C)C3)=CC4=N[NH1]C=C14 C[S@](=O)CCCN=C1N=C2N=CN(C)C2=C(NC3CCN(C4CC4)CC3)[NH1]1 CC1=CC=C(C(=O)N[C@H1]2CCC[C@@H1]2CNC(=O)CCN=C3[NH1]C=CS3)C=C1CO C[C@@H1](NC(=O)C1=CC=C(N2N=NN=C2O)C=C1)C3=NN=CN3C CC(C)C[C@H1](ONC(=O)CC1(C)CC1)C(=O)NCCCCN2CCCC2 COC(=O)CC1(CNC(=O)[C@@H1]2C[C@H1]3C=C[C@H1]2N(C(=O)C4(C(C)(C)O)CC4)C3)CC1 CN(C)C[C@H1](O)CC(=O)NC[C@]1(F)CCN(C(=O)C2=C(O)C=CC=C2Cl)C1 C[C@H1](OC1=CC=CC(Cl)=C1)C(=O)NCC2=CN(CC3=CC=C(C(=O)O)O3)N=N2 O=C(CC1=CC=C(O)C(F)=C1)N2CCC([C@@H1]3CCCN3C(=O)C=CCF)CC2 COCC1=NC(C(=O)N2CCCN(C(=O)CC3=NC=C(Cl)S3)C[C@H1]2C)=N[NH1]1 COC1=NC(Cl)=C(C(=O)N[C@@H1]2C[C@@H1]3CN(C(=O)[C@@H1](CO)C(C)C)C[C@H1]32)S1 CN(C)C1=CC=C(CN[C@@](CF)(C2=NN=NN2CC3CC3)C4CCCCC4)C=C1 CN(CCO)CCC(=O)N1CCOC2(CN(C(=O)C3=CC=C(F)C(N)=C3)C2)C1 CC1=CC(O)=NC=C1C(=O)N2C[C@@H1](NC(=O)[C@@H1]3CC34CCC4)CC[C@@H1](O)C2 C[C@@]1(CNC(=O)[C@@H1]2CCCN2C3=NC=CC=N3)CCCS1 CC[C@@H1]1CCO[C@@H1]1C(=O)N[C@H1]2C[C@@H1](C)CN(C(=O)C34CC5CC(CC(C5)C3)C4)C2 NC1=CC=CC(C(=O)N2CC[C@@H1](CNC(=O)C3=CC=CC(=O)N3O)C2)=C1 CC[C@@H1](C(=O)N[C@H1]1C[C@@H1]2CC[C@H1](C1)N2C(=O)C=3[NH1]C=CC=3C)C4=CC=CC(Cl)=C4 CC(C)(C)[C@H1]1CCCC[C@@H1]1OC(=O)C2=CC(C3=CC=C(Br)C=C3)=NS2 CC=1C=C(C(=O)NCCN(C(=O)[C@H1]2C[C@H1]2F)C3CC3)OC=1C C1C2=CC=CC=C2O[C@@H1]1C(=O)NC[C@H1](NC(=O)C=CC3=CC=CN=C3)C4CCC4C CCN(CC(=O)N1C[C@@H1]2C[C@H1]1CN2C(=O)C3=CC([N+1](=O)[O-1])=N[NH1]3)C4=CC=CC=C4 O=C(NCCC1CC1)[C@@H1](C2=CSC3=CC=CC(F)=C23)N4CCCC5(CC4)CC5 CC1=CC(C)=C(OC(=O)C2=CC=C(C3=CC=C(C)O3)S2)C(C)=C1 CCO[C@H1](C)C(=O)N[C@@]1(CF)CCN(C(=O)C(C)=C2CCCC2)C1 CCC1=NC(=N)[NH1]C=C1C(=O)N[C@H1]2C[C@@](C)(NC(=O)C[C@H1](C)N3C=CC(C)=N3)C2 O=C(CCOC1=CC=C(F)C(Cl)=C1)N2CCN(C(=O)C#C[C@H1]3CCOC3)[C@@H1](CO)C2 CCCC=CC(=O)NC1(CC(N)=O)CCN(C(=O)CCCC2=CC=NC=C2)CC1 COCCN1C=CC(C(=O)N[C@H1](C)CCCCNC(=O)[C@H1]2CCCCN2C)=N1 C[C@H1](C(=O)N[C@H1](C=1N=N[NH1]N=1)C2CC2)N(C(=O)[C@@H1](O)C3=CC=CN=C3)C4CC4 C[C@]1(CNC(=O)C2=CC=CC=N2)CC[C@H1](NC(=O)C(F)(F)C3=CC=C(Cl)N=C3)C1 CC(=O)NCC1CCC(C(=O)N(C)C2=NC=C(C(C)C)S2)CC1 CC(C)(C)N1CC[C@@H1]1CNC(=O)[C@@H1]2CN(C(=O)C3=CSN=C3Cl)CC2(F)F CN(CC1(O)CN(C(=O)[C@@H1]2[C@H1]3CCCO[C@H1]32)C1)C(=O)[C@H1](F)CC4=CC=CC=C4 C#CC1=CC=C(C(=O)N2CCSC[C@H1]2CCNC(=O)[C@]3(C)CCCCO3)O1 CCC1(C(=O)NCCN(CC2=CC=CC(Cl)=C2)C(=O)[C@H1]3CCC[C@@H1]3C)CCCC1 COC1CCC(C(=O)N(CCO)[C@H1]2CCN(C(=O)C(C)=CC3CCCC3)C2)CC1 COC1=CC=C(C(=O)N2CC[C@@](C)(NC(=O)[C@@H1](F)N3C=CC=N3)C2)C(C(F)F)=C1 CC1=NC(C(=O)N(C)CCNC(=O)[C@H1]2[C@@H1](C)[C@H1]2C)=C(Br)S1 CC[C@H1](CC(F)F)C(=O)NCC[C@@]1(C)CCN(C(=O)[C@]23COC[C@H1]2CN3C)C1 CCC(CC)CCC(=O)NCC[C@@H1](C)N(C)C(=O)[C@H1]1CCC2=CN(C)N=C2C1 CC(=O)C1=CC=CC(C(=O)N2CCO[C@H1](CNC(=O)CC3=CSC(C)=N3)C2)=C1 CC[C@H1](C(=O)N[C@H1]1C[C@]2(CCCCN2C(=O)CC3CCC3)C1)N4N=CC=C4C C#C[C@@H1]1CN(C(=O)[C@@H1](O)CCCC)CCN1C(=O)CN2C=CC=CC2=O COCCOC1=CC=C(C(=O)N2C[C@@H1](O)C[C@H1](NC(=O)[C@H1](SC)C(C)C)C2)C=C1 COC1(OC)CC(C)(CN=C2N=C3C(C=NN3C)=C(NCC(C)(C)CSC)[NH1]2)C1 CC(C)C[C@](C)(CNC(=O)C(C)(C)CCCO)NC(=O)C1=CC=C2C=NSC2=C1 CCC=1ON=C(C)C=1C(=O)N2CC[C@](CNC(=O)[C@@H1]3CCCC[C@@H1]3O)(C4CC4)C2 CN(C)CC(C)(C)CC(=O)NC/C=C/CNC(=O)C1=CC=NN=C1NC2CCC2 CC(C)(C)OC1=CC=CC(C(=O)NC[C@@H1]2C[C@@H1]2NC(=O)C3=NN=C(O)N=C3O)=N1 CCC=1N=NSC=1C(=O)N2CCC([C@H1]3C[C@@H1]3NC(=O)C4=CC(F)=CN=C4O)CC2 C[C@@H1]1C[C@@]2(C(=O)NC34C[C@H1]5C[C@@H1](CC(CNC(=O)CN(C)C)(C5)C3=O)C4)C[C@@H1]12 COC1=CC=C(C(=O)NCC2(NC(=O)C3=COC4=CC=CC(Br)=C34)CC2)N=C1 CC1=NC=CN1CCC(=O)N2[C@H1](CNC(=O)C=3SC=CC=3F)C[C@@H1]4CCCC[C@@H1]42 C[C@@H1](N1N=C(C2=CC(Cl)=CC=N2)N=C1C3=CN(C(F)F)C=N3)C4(C)CC4 CC[C@@H1]1CN(C(=O)C2=CC=NC=N2)CC[C@H1]1NC(=O)C3=NC=CN=C3C(F)(F)F CN(CCNC(=O)[C@@H1]1CC12C3CC4CC(C3)CC2C4)C(=O)[C@H1]5CC[C@@H1](N(C)C)C5 CC1(C)[C@H1](C2=CC=CC=C2)CCN1C(=O)N[C@H1]3C[C@@]3(C)C4=CC=CC=C4 CNC(=O)NCC(=O)N[C@H1]1CN(C(=O)C2=CC=C(C3=CC=CO3)S2)CC[C@H1]1C CN=C(NCC[C@H1]1CCC2(CCOCC2)CO1)NC[C@@H1](C)N3C=CC=N3 CC(C)[C@H1](C(=O)NC1(CNC(=O)COCCCN=[N+1]=[N-1])CC1)C2=CC=CC(Cl)=C2 O=C1C[C@H1]2[C@@H1](C1)[C@@H1]2C(=O)N3C[C@@H1](CC(=O)N4CCC45CCCC5)C6(CC6)C3 C[C@H1](NC(=O)[C@@]1(CO)CCCO1)C(=O)N2CCCCCCC2 C#CCCOCC(=O)N(C)CCNC(=O)C=1N=NN(C(C)C)C=1C CC(C)C[C@H1](C(=O)N1C[C@H1]2C[C@@]1(C3=CN([C@H1]4CCCNC4=O)N=N3)CO2)N(C)C CCOCCCN=C(NCCOC1=CC=C(F)C(F)=C1)NC[C@]2(OC)CCOC2 CC1=CC(C(=O)NC[C@H1](C)N(C)C(=O)C=2N=COC=2C)=NC=C1F O=C(C1=CSC(O)=N1)N2CCCC[C@@H1](CNC(=O)C3(C4CC4)CC3)C2 O=C(NCCC1CCOCC1)[C@H1]2CN(C(=O)CSC=3N=C[NH1]N=3)CC24CC4 CO[C@](C)(CO)C(=O)N1CCC(C(=O)N2CC(C3=NO[C@@H1](C)C3)C2)=C(F)C1 CC1=CC(C(=O)N[C@H1]2CC[C@H1](CNC(=O)[C@@H1]3CCNC(=O)CN3C)C2)=N[NH1]1 C[C@@H1](C(=O)NCCOCC(F)F)N(C(=O)C(C)(C)N1C=NN=N1)C2CC2 CC1=CSC(C(=O)NC[C@H1](O)CN(C)C(=O)C=2C=CSC=2C(F)F)=C1C O=C(CCC(F)F)N[C@H1]1C[C@H1]2CC[C@@H1]([C@@H1]1F)N2C(=O)C3(C4(O)CCOCC4)CC3 C[C@@H1](NC(=O)C=CC1=CC=CC=C1)C(=O)NCCCNC(=O)[C@@H1]2C[C@H1]2C3CCC3 CCCC=CC(=O)N1CC[C@H1](NC(=O)CSC=2C=NN(C)C=2)[C@@H1](CO)C1 COC1(C(=O)N[C@@H1]2C[C@@H1]3C[C@H1](NC(=O)C=4C=CC5=CN(C)N=C5C=4)C[C@@H1]32)CCC1 COC1=NC=C(C(=O)N2CCC[C@@H1](C3=CN(CC4=CSC=N4)N=N3)C2)C=C1Cl CN1CC[C@H1](NC(=O)CCC2=CN=CS2)[C@@]13CCCN(C(=O)C4=C(Cl)CCC4)C3 COC1=CC=C(S(=O)(=O)NC(=O)CC2=CC=CC3=CC=CC=C23)C(F)=C1OC CC1=CN2N=C(N3CCC[C@@H1]3CCNC(=O)[C@H1](NC(N)=O)C(C)(C)C)SC2=N1 CCCCN(CC)C(=O)C[C@H1]1CCCN(C(=O)[C@H1](CCOC)OC)C1 CC(=O)C1=NC=CC=C1C(=O)N(C)C[C@@H1]2CCC[C@@H1](NC(=O)C3CCCC3)C2 O=C(NC[C@H1]1C=CCN1C(=O)C2=CC=C(N3CCOCC3)C=C2)C4=CN=CS4 CC(C)(CC1CC1)C(=O)NC2C[C@@H1]3CCC[C@H1](C2)N3C(=O)CCN4C=NC(=N)[NH1]4 COC1=CC=C(C(=O)N2C[C@H1]3CCN(C(=O)C=CC4=NC=CS4)[C@@H1](C3)C2)C(Cl)=C1 CN(C[C@@H1](O)CN(C)C(=O)C1=CC2=C(S1)CCCC2)C(=O)C=CC3CCCC3 O=C([C@@H1]1CCN1C(=O)[C@H1]2C[C@@H1](O)C2)N3CCO[C@@H1](C4CC4)CC3 N#CC=1C(Cl)=NSC=1N2CCC3(CCC3)[C@@H1](CNC(=O)C[C@H1]4CC4(Cl)Cl)C2 C[C@H1]1CN(C(=O)[C@@]2(C)CCCO2)C[C@H1]1NC(=O)C3=C(F)C=CC(F)=C3O CSC1=NC=CN=C1C(=O)N(C)CCCCN(C)C(=O)[C@@H1]2CCC[C@H1]3CCCN32 CN1C[C@H1]2C[C@@H1]1CN2C(=O)[C@@H1]3COC4(CCN(CC5=CC=C(Cl)C=C5Br)CC4)C3 CCC[C@@H1](C(=O)N[C@H1](C)CNC(=O)C1=CC=CC2=CC=CC(Br)=C12)N(C)C COC1(C(=O)NC[C@@H1]2[C@H1](C)CCN2C(=O)C3=CC4=CC=CC(F)=C4O3)CC1 COC1=CC=CC=C1N2N=NN=C2[C@H1](NCC(C)(C)F)C3=CN=NN3C O=C(CC1=CC=CN=C1Br)NC[C@H1]2CCN(C(=O)[C@H1]3CC34CC(F)(F)C4)C2 CCN1C[C@H1]2CN(C(=O)[C@@H1](CNC(=O)C3(NC(N)=O)CC3)C(C)C)C[C@H1]2C1 CC[C@H1](C)[C@H1](O)C(=O)N[C@H1]1C[C@H1]2C[C@@H1](NC(=O)C(F)(F)C3=CN=CS3)[C@@H1]1C2 CO[C@@H1]1CCC[C@H1]1C(=O)NCC=2C=C3N(N=2)CCN(C(=O)C4=COC(C#N)=C4)C3 CCOC(=O)C1=CC(OCC)=CC=C1NC(=O)C2=CC=C([N+1](=O)[O-1])C=C2C COC(=O)C1=CC=CC([C@H1](F)CN[C@@H1](C)CC2(C)CC2)=C1 CCCC[C@H1](C(=O)OC)NCC12CCC(CC1)C2 CC=1C=COC=1CC(=O)NCC2(O)CN(C(=O)[C@@H1]3CC(C(C)C)=NO3)C2 C[C@@H1](NC(=O)C[C@H1]1CCCO1)[C@@H1](CO)NC(=O)C=CC2=CC=CC(F)=C2 CC1=CC(C(=O)NCC2=CCN(C(=O)C3=CC=C(O)N=C3)CC2)=CN=C1F C[C@@]1(NC(=O)C[C@@H1](O)C2=CC=CC=C2)CCN(C(=O)C3CC(N4C=CC=N4)C3)C1 C=CC1(CC(=O)NC[C@@H1](CC)NC(=O)[C@](C)(O)C2=CC=C(F)C=C2)CCCCC1 C=CC[C@H1](CNC(=O)[C@H1](F)CN(CC)CC)NC(=O)CCC1=CC=C(F)C=C1F CCC[C@@H1](C)C(=O)NCC[C@@H1]1CCCN(C(=O)CCN2C=NC(C)=CC2=O)C1 CC(Cl)=CC(=O)N[C@@H1]1C[C@H1](CNC(=O)[C@@H1](C)C=2C=C[NH1]N=2)C[C@H1]1O CCOC(=O)[C@@H1](CC1CC1)NC(=O)C=2C=C(C3=CC=CO3)[NH1]N=2 O=C(NC1CC(CNC(=O)C2=CC(C3=CC=CC(Cl)=C3)=NS2)C1)C4=COCC4 O=C(CCC=1C=CSC=1)NCC2=CCCN(C(=O)C3CN(C4CCOCC4)C3)C2 C[C@@H1](CCNC(=O)C1=CC2=C(S1)CCCNC2=O)NC(=O)[C@@H1]3C[C@@H1]4CCCC[C@@H1]43 O=C(NC[C@H1]1CN2CCC1CC2)[C@@H1]3[C@H1]4[C@H1]5C[C@H1]3[C@@H1](NC(=O)C6=NC=CC=C6F)[C@@H1]45 CCCC=CC1=C[C@@H1]([C@H1](C(=O)NCC(C)C)N2CCOC3(CCCC3)CC2)C=C1 CC[C@@H1](O)C(=O)N(CCNC(=O)CC1(COC)CCCC1)C2CC2 CC[C@@](C)(OC)C(=O)NCC=1OC=CC=1C(=O)N[C@@H1]2CCC[C@@H1](C(N)=O)C2 CN(C[C@@H1]1C[C@H1]1C2=CC(F)=C(F)C(F)=C2)CC(=O)C3CCC3 CC(C)C[C@@H1](CN(C)C)NC(=O)C12CCC(CC1)N(C(=O)[C@H1]3CNC(=O)C3)C2 CS[C@H1](C(=O)NCC1([C@H1](C)NC(=O)CCOC(C)C)CC1)C2CC2 CN1CC[C@@](C)(C(=O)N(C)[C@H1]2CCCC[C@@H1]2N(C)C(=O)C3CC3)C1 C[C@@H1](NC(=O)[C@H1]1CC(C2CC2)=NO1)C3CC(NC(=O)CCCCC#N)C3 CO[C@H1]1C[C@@H1](CNC(=O)CC(F)F)N(C(=O)C(C)=CC2=CC=CO2)C1 COCC1=CC(CC(=O)N[C@H1](C)CC2CN(C(=O)[C@@H1](F)CC3CC3)C2)=NO1 CCOCCN(CC)C(=O)C1(SC)CN(C(=O)C#CC2CCOCC2)C1 C[C@@H1]1OCC2(CCN(C(=O)C=3N=CN(C)N=3)CC2)[C@H1]1N4CCN(C)CC4 O=C(N[C@@H1]1C=CCN(C(=O)[C@@H1]2[C@@H1]3CCC(=O)[C@H1]32)C1)[C@H1]4CCCC5=N[NH1]C=C54 C[C@H1](C(=O)N1C[C@H1](C)[C@@H1](NC(=O)C2=CC=3C=C[NH1]C(=O)C=3S2)C1)C4CCC4 C[C@H1](CN=C1[NH1]C2=C(C(=NCC3(C)CCC(O)CC3)[NH1]1)SCC2)S(C)(=O)=O CC(=O)C1=CC=CC(C2=CC=C3OC(C(=O)NC4=CC(I)=NC=N4)=CC3=C2)=C1 CC(=O)N[C@H1]1CC[C@H1](C(=O)N[C@@H1](CO)CNC(=O)C2=NC=CC=C2C(F)F)CC1 CC(C)N(C)CC(=O)NCC(C)(C)C#CC(=O)N1CC(NC(=O)C2CC2)C1 CC1=NC(C(=O)N2CC[C@H1]3[C@@H1]2C[C@H1]3NC(=O)C4=C[NH1]C5=NC=CC5=C4)=CO1 CCC1=C[NH1]C(C(=O)N[C@@H1]2[C@@H1](C)CN(C(=O)CCN3C=NN=N3)C[C@H1]2C)=C1 CC=1[NH1]C(C(=O)N[C@@H1]2CCN(CC3=COC4=CC=C(F)C=C4C3=O)C2)=C(C)C=1C CN1C=C(C(=O)C(=O)N[C@@H1]2C[C@@H1]3C[C@H1](NC(=O)CC4=CSC(S)=N4)[C@H1]2C3)C=N1 CN1N=NC=C1C(=O)N2C[C@H1]3C[C@@H1](NC(=O)C4=CC(Cl)=CS4)C[C@H1]2C3 CCSC[C@@H1](C)C1=CN(CCCNC(=O)C=2ON=CC=2CC)N=N1 COC1=CN=CC(C(=O)NC[C@@H1](NC(=O)[C@@H1](F)CC2CCC2)C3CCC3)=C1C CCOC(=O)CNC(=O)[C@H1]1CN(C(=O)[C@]2(C)CCCN2C(C)=O)CC1(C)C COCC1=NN=C(NC(=O)C2=CC(Cl)=C(C3=CC=C(Cl)C=C3)C(F)=C2)N1C CCCN1C(=O)N(CC(=O)N(C)CCNC(=O)[C@@H1]2C[C@H1]2F)C3=CC=CC=C31 CNC(=O)CN(C)C1=CC(S(=O)(=O)N[C@H1](CC2=CC=NC=C2)C3CC3)=CC=C1Cl C#CCCC(=O)N(C)[C@@H1]1CCC[C@H1](NC(=O)C2=CCCCO2)C1 CN(C[C@H1]1[C@@H1]2CN(C(=O)C=C3CCOCC3)C[C@H1]12)C(=O)[C@]4(C)CCC(=O)N4 CNC(=O)[C@H1](C1=CC=C(C(F)(F)F)C=C1Cl)N2CCC(N3N=C(C)N=C3C)CC2 C[C@H1](NC(=O)C1(C)CCC1)[C@@H1]2CN(C(=O)CC3=NC(=N)[NH1][NH1]3)CCO2 C[C@@H1](CO)C1CCN(C(=O)C2CCN(C(=O)C3(C)CC(=O)C3)CC2)CC1 CCOC(=O)[C@@H1]1CCCN(C(=O)CN2CCCO[C@H1](CCO)C2)C1 C[C@H1]1CC[C@H1](CNC(=O)C2SCCS2)N(C(=O)[C@@]3(C)CCCNS3(=O)=O)C1 CCCC1(C(=O)NC[C@@H1](F)CNC(=O)C2=CSC(Cl)=C2OC)CC1 CC1=CN=C(CC(=O)NCCC2CN(C(=O)C3=CC=C(C4CC4)C(F)=C3)C2)[NH1]1 CN=C1[NH1]C(C(=O)N(C)C[C@H1]2CCN(C(=O)[C@H1](F)C(F)(F)C(F)(F)F)C2)=CS1 CC1(C(=O)N2C[C@@H1]3COCC[C@]3(NC(=O)C4=CC=CC(C)=N4)C2)CCCC1 C[C@@H1](CN(C)C(=O)C(F)=CC1=CC=CN=C1)NC(=O)C2=CC=C(N)C3=NC=CC=C23 C=C1C[C@@H1]1C(=O)NC[C@H1](NC(=O)CC2=NC=C(C)S2)C3=CC=C4C=CC=CC4=C3 CCCC[C@H1](NC(=O)C1=CC=C(OC)N=N1)C(=O)N2CC3(CCC3(C)C)C2 C[C@@H1]1C[C@H1](NC(=O)C2=CN=C([C@H1]3CCCO3)S2)CCN1C(=O)CC4=CC=NN4C CCCC[C@H1](CC)CC(=O)N1C[C@]23CCC[C@@]2(CN(C(=O)C[C@H1](C)SC)C3)C1 COC1=CC(C(=O)N(C)C[C@H1](C)NC(=O)C2=NN=C(C(C)C)S2)=CC([N+1](=O)[O-1])=C1 CN1OC(C(=O)N[C@H1]2CCC[C@@H1]2NC(=O)[C@@H1]3CCCN3C(=O)C(C)(C)C)=CC1=O CCOC1=CN=CC=C1C(=O)N[C@H1]2C[C@@H1](C(=O)NC3=CC=C(Cl)C(C)=C3)C2 CC(C)OCC(=O)N[C@H1](C(=O)N[C@@H1](C)C=1SC=NC=1Cl)C2(C)CC2 CN1C=NC(C=CC(=O)N2C[C@H1](CNC(=O)[C@@H1]3CCCC(C)(C)C3)C(F)(F)C2)=C1 CC(C)(C)C1=CC(C(=O)N2C[C@@H1](NC(=O)C3=CC=C(C(F)(F)F)[NH1]3)[C@H1](C)C2)=NO1 CCCN1[NH1]C=NC1=N[C@@H1](C)C2=CC=CC=C2CC CCC1=CC=CC(OCC(=O)N[C@H1]2CC[C@H1](NC(=O)[C@H1]3CC[C@H1](CC)C3)CC2)=C1 O=C(CCOCC(F)F)N[C@H1](C(=O)N[C@@H1](CO)C1CCCC1)C2=CC=CC=C2 CN(C)C(=O)[C@@H1]1CCN1C(=O)C[C@@H1](NC(=O)[C@H1]2COCC2(C)C)C(F)F CC1(CCNCC2=CC=CN2C3=NC=CS3)CCN1 N=C1[NH1]C(Cl)=C([N+1](=O)[O-1])C(=NC[C@H1](NC(=O)C2=CN=CO2)C3CC3)[NH1]1 COCCN1CCN(C(=O)[C@@H1](CNC(=O)[C@@H1](C)CC(F)F)C(C)C)CC1 CC1(CC(=O)NC2=C(F)C=C(I)C=C2F)CN(C(=O)C3=CN=CC=C3C#N)C1 C=CC1(C(=O)N[C@@H1](C)CCCNC(=O)C2=CC=CC=C2O)CCC1 CO[C@H1](C)CCC(=O)N1CCC[C@](O)(CNC2=NC(Cl)=NC=3N=CN(C)C2=3)C1 CCC1=CON=C1CC(=O)NCCC2(CNC(=O)[C@H1]3C[C@H1]3Cl)CC2 CCN(C(=O)C1=N[NH1]C2=C1CCC2)C3CCN(C(=O)C4=CC=5OC=CC=5[NH1]4)CC3 O=C1CN(N2CCC[C@@]3(CCCO3)CC2)C4(CCC4)C1 CCCC[C@H1](O)CC(=O)NC[C@H1](C)[C@H1](F)C(=O)NCC1=CON=C1C CC(C)[C@H1](CCN(C)C(=O)C(=O)N1CC[C@@H1](C)C1)N=C2N=CC(I)=C[NH1]2 CC=CC=CC(=O)NC[C@@](C)(CO)NC(=O)C1=CC(Cl)=NS1 CC1=CC=C(C(=O)O)C=C1CN2CC[C@H1](CC(=O)NC3=CC=C4ON=CC4=C3)C2 C[C@H1]1CCN(C(=O)/C=C/C=2C=C(Cl)SC=2Cl)[C@H1]1CNC(=O)CCCNC(N)=O CC1(NC(=O)[C@]23C[C@H1]2CCN3C(=O)[C@H1]4CC5(CC5)CO4)CC(O)(CO)C1 C[C@@H1](CNC(=O)[C@@H1]1CC(=O)N(C)C1)CN(C)C(=O)C2=CC=C(F)C(Br)=C2 CCC(CC)(CO)C(=O)NCC1(NC(=O)C2=CN=NN2CC3=CC=CC=C3)CC1 CC1=CC=NC(N[C@@H1](C)[C@@H1]2CCN(C(=O)C3=CN4C=NN=C4C=N3)C2)=N1 C[C@@H1](O)C1CCN(C(=O)C2(N(C(=O)C[C@@H1]3C=CCC3)C4CC4)CCC2)CC1 O=C(NC[C@]1(O)CCCN(C(=O)CO[C@@H1]2CCOC2)C1)C=3C=C(C(F)F)[NH1]N=3 CC=1C=CN2N=CC(C(=O)N[C@@](C)(CO)CNC(=O)CC=3C=CSN=3)=C2N=1 COCC1(C(=O)NC[C@]2(C)CCC[C@H1]2NC(=O)CCC3=CN=CC(O)=C3)CC1 CO[C@H1](C(C)C)[C@H1](O)C(=O)N(C)[C@@](C)(C(=O)NC1(CC(C)C)CC1)C2CC2 CC1CC(C)(C(=O)N2CC(O)(CN(C)C(=O)CCN=C3[NH1]C=CS3)C2)C1 CCC[C@@H1](NS(=O)(=O)C1=CC=C(NCC2CCOCC2)N=C1)C3CCCC3 CC1=CC(F)=CC(Cl)=C1C(=O)N[C@@H1]2CCCCN(C(=O)CN3CCCCC3=O)C2 CC(C)N1C=C(C(=O)N[C@@H1]2CN(C(=O)[C@@H1]3CC(C4CC4)=NO3)CC25CC5)C=N1 COC[C@H1](C)C(=O)N[C@H1]1CCCC12CN(C(=O)[C@H1](C)C3=CC=C(C)C=C3)C2 CC=1SC=CC=1C(=O)N[C@@H1]2C[C@H1]3CN(C(=O)C=4C=CN(CC#N)N=4)C[C@H1]32 O=C(NC[C@H1]1CCCCN1CCCO)[C@@H1]2CCCC3(CCCCC3)C2 C#CCC1(C(=O)N[C@@H1]2CC[C@H1](NC(=O)CC3(CC)CCOCC3)C2)CCC1 CC[C@@H1](NC(N)=O)C(=O)N[C@H1](C)CCCNC(=O)C=1OC(C)=NC=1C CC[C@@H1](C)NC(=NC1CC(OC(C)(C)C)C1)N2CC[C@@H1](C3=CC=CC=C3OC)C2 CC1=CC=CC=C1[C@@H1](C)NC(=O)[C@@H1]2CC[C@H1](CNC(=O)C3=CC=CC(F)=C3N)O2 O=C(N[C@@H1]1CN(C(=O)COCC2CC2)[C@H1]3C[C@H1]13)C4=CC(NC5CC5)=NC=C4Cl CC1=CN(C)C=C1C(=O)N(C)CCCNC(=O)CC2=CC3=CC=CC=C3C=C2O CCC1=NC=NC=C1C(=O)N[C@@]2(C)CCCN(C(=O)[C@H1](C)CC(F)F)C2 CC1=NOC(Cl)=C1CC(=O)N[C@H1](C)CN(C)C(=O)[C@@H1]2CC3=CC=CC=C3O2 CC[C@@H1](C)C(=O)N[C@@H1]1CCN(C(=O)C2=CC(I)=CC=C2O)C[C@H1]1O CN(C(=O)CNC1=NC=CC=N1)[C@H1](CC(F)F)C(=O)NC[C@H1](CO)C2CCC2 CCC1=C(Cl)N=CN=C1N2CC[C@@H1](N3CCN(C(=O)[C@@H1]4CCS(=O)(=O)N4)CC3)C2 CC1=CC(=NC(=O)CCN(CCO)C(=O)C23CC(C#N)(C2)C3)[NH1]N1C CN1CCCC[C@@H1]1C(=O)NC[C@H1]2CCC3(CCN(C(=O)[C@H1]4C[C@@H1](O)C4)CC3)CO2 C=CC(C)(C)CC(=O)NC[C@@]1(NC(=O)C2=CC([N+1](=O)[O-1])=C(C)S2)CCCC[C@@H1]1C CC=CC=CC(=O)N1CCN(C(=O)[C@H1]2CCN2CC)[C@@H1](C3=CC=CC=C3CC)C1 CC1=NC(C)=C(C(=O)N2CCO[C@H1](CC(=O)NCC[C@@H1](C)N3CCC3)C2)O1 CC(=O)O[C@H1]1C[C@@H1]1C(=O)N[C@H1](CO)C(=O)NCC(F)(F)CO CCC1=NC=C(C(=O)N[C@H1]2CO[C@]3(CCN(C(=O)CC4CCOCC4)C3)C2)O1 CC1=CN=C(F)C=C1C(=O)N2CCC[C@@H1](NC(=O)CSC3=NN=CN3C)[C@H1]2C COCCCOCCC(=O)NC[C@@H1](C(=O)N1CC[C@@H1](OC)C(C)(C)C1)N(C)C O=C([C@H1]1OC2CCC1CC2)N3CCC[C@]4(CCN(C(=O)C5(F)CCCCC5)C4)C3 CC[C@H1](C)[C@H1](O)CC(=O)N(C1CC1)[C@H1](C)C(=O)N2CCC=C(Cl)C2 CC1=NC=CN=C1C(=O)N[C@@H1]2CN(C(=O)C3=CC(C(F)(F)F)=CS3)CC2(C)C CC1(F)CC(C(=O)N2C[C@H1]3CC[C@H1]2[C@@H1](NC(=O)C=4C=NSN=4)C3)C1 CC(=O)NCC(=O)N1CCC[C@@H1]([C@@H1](C)NC(=O)C2=CC=CC(C(C)(C)C)=C2)C1 CN(C(=O)C1SCCS1)[C@H1]2CCN(C(=O)[C@H1](O)C(F)(F)F)C2 CC1(C)C[C@H1]1CC(=O)N2CC[C@@H1]2CNC(=O)C3=CC4=C([NH1]3)CCCC4=O CCCC1(C(=O)NC[C@@H1]2C[C@H1]2CNC(=O)[C@@H1]3CC(=O)C4=CC=CC=C43)CC1 C=CC[C@@]1(NC(=O)C=2SC=CC=2COC)CCN(C(=O)[C@H1]3CCCO[C@H1]3C)C1 CCCCC[C@@H1](O)[C@@H1](C)C(=O)N1CC(NC(=O)CC2=CN(C)N=C2C)CC13CC3 COC1=CC=C(C2CC2)C(C(=O)NC3=N[NH1]C(C(=O)N4CCCC4)=N3)=C1 C#CCNC(=O)CC(=O)N1C[C@H1](CNC(=O)CN2C=NN=N2)[C@H1](C(F)(F)F)C1 CC[C@@H1](C(=O)N(C)[C@@H1](C)CNC(=O)C=1C=C(C2=CC=CO2)ON=1)C(F)(F)F CC=C(C)C(=O)N1CC[C@H1](CCNC(=O)C2=CC(C#N)=CC=C2C)C[C@@H1]1C COC1=CC=C(C(=O)N2CC(O)([C@@H1](C)NC(=O)[C@@H1]3C[C@@H1](F)C(=O)N3)C2)C(N)=C1F CC[C@@H1](C(C)C)[C@H1](C(=O)NCC(C)C)N1CCC=C(C)C1 CC1CC(N(C)C(=O)C2=CCN(C(=O)[C@H1]3CC[C@@H1](C)C3)CC2)C1 CC/C=C/CC(=O)NC[C@@H1]1CN(C(=O)C2=CC=CC3=C2OCCC3)C[C@H1]1C CCN(C[C@@H1]1CCOC1)C(=O)[C@@]2(CC)CCCN(C(=O)[C@@H1]3CC34CC4)C2 CCOC(=O)C1(C(=O)NC[C@H1]2CCN2C(=O)C[C@@H1](CC)C(C)C)CC1 C[C@@H1](C(=O)N1CCC[C@@H1](N(C)C)C1)N(C)C(=O)C2=CC=C([N+1](=O)[O-1])O2 C[C@@]1(C(=O)N2CCC3(CC2)CC(NC(=O)C4=CC=C(F)C=C4)C3)CCCS1(=O)=O C[C@@H1]1CN(C(=O)C2=CC=C(N)C=C2Br)CC[C@H1]1CNC(=O)C3=CC=CC=C3 CCCC[C@H1](O)CCC(=O)N[C@H1](CNC(=O)[C@H1](CC)[C@H1](C)O)CC(C)C C#CCSCC(=O)N[C@@H1]1CS(=O)(=O)[C@H1]2CN(C(=O)[C@H1]3CC4(CC4)CO3)C[C@@H1]12 CN(CCCCCCNC(=O)C1(C)CC1)C(=O)CN2C(=O)[C@@H1]3CCCC[C@H1]3C2=O COCCC(C)(C)NC(=O)C=C(C)CNC(=O)[C@H1](C)CN1C=CN=C1 O=C(CC1(NC(=O)C2=CC=NO2)CCCC1)NCCC3=CC=C(F)C=C3 C=CC1(CC(=O)NC2[C@@H1]CN(C(=O)[C@H1]3CCS3(=O)=O)CC4(CCC4)O2)CC1 CN1CC=C(C(=O)N[C@H1]2C3C[C@H1]4[C@@H1](C3)C24C(=O)NCCN5CCC(C)(C)C5)C1 CC1=CC=C(C2=CC=C(C)C(NC(=O)C(=O)N[C@@H1]3CC[C@@H1]([S@](C)=O)C3)=C2)N=N1 CC[C@H1](CC(=O)NC1C[C@@H1](NC(=O)C(C)(C)SC)[C@H1](CC2CC2)C1)C(C)C C[C@](O)(C(=O)N1C[C@@H1]2CC[C@H1](C1)N2C(=O)[C@H1](F)C[C@H1]3CCOC3)[C@@H1]4CCOC4 CC1=NC(C(=O)N2CC[C@@](CO)(NC(=O)C3=NC=CC=N3)C2)=CN1C(F)F CCCN(C(=O)C1=NN=C(Cl)C=C1N)[C@@H1]2CCN(C(=O)C3=C(F)C=NC=C3Cl)C2 N#C[C@H1]1CN(CC2=CC3=CC=NC=C3[NH1]2)CCN1C(=O)C4=C(Cl)C=CC(F)=C4Cl C[C@H1]1CN(C(=O)C2=CC(Cl)=NS2)C[C@H1](C)N(C(=O)CSC3=CC=NC=C3)C1 CCCCC[C@H1](CC)C(=O)NC[C@@H1]1CCN(C(=O)C=2C(Cl)=NN(C)C=2Cl)C[C@@H1]1C C=CCC1(C(=O)N[C@H1]2C[C@@]2(C)C(C)C)CN(C(=O)CCC)C1 COC1=N[NH1]C(C(=O)NC[C@@H1]2CC3(CO2)CN(C(=O)CC=4C=CON=4)C3)=C1Cl CC(C)N1C=CN=C1C(=O)N[C@@H1]2CN(C(=O)C=3C=NN(C(F)F)C=3)CC[C@@H1]2CO O=C(NCC1=CC=CN=C1)[C@@H1](NC(=O)[C@]23C[C@H1]2CNC3=O)C4CCC4 COCC1=CC=C(C(=O)OCC(=O)[C@@H1]2CC23CC(C(=O)OC(C)(C)C)C3)[NH1]1 CN(CCCNC(=O)CCNC1=CC=CC=N1)C(=O)C2(S(N)(=O)=O)CCCC2 C#CCN(C)C(=O)C1(F)CCN(C(=O)[C@H1](O)C2CCC2)CC1 C[C@@H1](O)CC1=CN(C=2[NH1]N=C3C=C(C(=O)NCCCC#N)C=CC=23)N=N1 C=CCC(=O)N1C[C@]23CCC[C@]2(C1)CN(C(=O)C4=CC(C(F)(F)F)=NC=C4N)C3 CC=1C=CSC=1CC(=O)N[C@@H1](CC(=O)N(C)CC2=CC=CC(O)=C2)C(F)F CCC(CC)CN(CC)C(=O)[C@H1]1CC12CCN(C(=O)[C@@H1]3C4C[C@@H1]5C3[C@@H1]5C4)CC2 CCCC=C=CC(=O)N1CCC(O)(CNC2=CC(C)=NC3=NC(C)=NN23)CC1 COCC=1C=C[NH1]C=1C(=O)N(C)[C@@H1](C)CNC(=O)C(C)(C)C2=CC=C(C)C=C2 CC(C)C1CC(C(=O)N2CC(N(C)C(=O)CNC(=O)CC3CCCCC3)C2)C1 COC[C@H1]1CN(C(=O)[C@H1]2C=CCC=C2C)CCN1C3=NC=C(C)C(OC)=N3 CCC1=NNC2=C(C(=O)N[C@H1]3C=CCN(C(=O)[C@@H1]4CCS(=O)(=O)C4(C)C)C3)C=NC12 C=C[C@@H1](OC)C(=O)N(CCOC)C1CCN(C(=O)C(F)(F)C2=CCOCC2)CC1 CCC1=NOC=C1C(=O)NCC[C@]2(O)CCCN(C(=O)C[C@H1]3CCCC(=O)C3)C2 CC(C)C1=CC=C(C(=O)N2CC[C@](O)(CCNC(=O)CCC(N)=O)C2)C(O)=C1 CCCN(CCNC(=O)C[C@H1](O)C1=CC=CC(F)=C1)C2=NC=C3C=CSC3=N2 O=C([C@H1]1C[C@H1](F)CN1S(=O)(=O)C2=CC(F)=C(Br)C=C2F)N3CC[C@H1](O)C3 CC1=NC=CC=C1C(=O)NCC2=CC=C(C(=O)N3CCCCC3)N=C2 N#CC1=C[NH1]C(C(=O)N2CC=C[C@H1]2CNC(=O)C[C@H1]3CCCS(=O)(=O)C3)=C1 COC(=O)CCCCC(=O)N[C@H1]1CCCCCN(C(=O)CC2=CN(C)N=C2Cl)C1 CC(Cl)=CC(=O)N[C@@H1]1C[C@H1]2C[C@@H1]1CN(C(=O)CCC3=CC=CC4=CN=CC=C34)C2 CNS(=O)(=O)C1=CC=CC(C(=O)N(C)C[C@H1](C)N(C)C(=O)C2=CC(C)=NO2)=C1 C[C@H1](C(=O)N1C[C@@H1]2C[C@H1](C1)CN(C(=O)[C@]3(C)C[C@H1]3Br)C2)N4C=C(Cl)C=N4 CC1=C(C(=O)NC23CC(C(=O)NC[C@H1](C(C)C)N(C)C)(C2)C3)C=NN1C NC(=O)C1=CC(C(=O)NCCC2CC(NC(=O)C(F)=CC3CC3)C2)=N[NH1]1 N#CC1=CC=CC(C(=O)N2CCC(F)(C(=O)N[C@H1]3C[C@@H1](CO)[C@@H1]3O)CC2)=C1 CCOC1=CC=C(C2=CN(CC(=O)N3CC[C@H1](OC4CCOCC4)C3)N=N2)C=N1 CN(C[C@H1]1CN(C(=O)C2(C)CC2)CCO1)C(=O)[C@H1](C3=C(F)C=CC=C3F)N(C)C CC1=CC=2[NH1]C(C(=O)N3CCN(C(=O)C4=NC=C(Cl)C=C4F)CC3)=CC=2O1 C[C@H1](C(=O)N1CC[C@@H1](CC(=O)NC2(C(F)F)CCC2)C1)N3CCOCC3 C[C@H1](CSC(F)(F)F)C(=O)N1CCN(C(=O)C2=CCOCC2)C[C@H1]1CO NC=1C=C(S(N)(=O)=O)SC=1C(=O)NC[C@@]23CCCC[C@H1]2C3 CCN1C=NC([C@@H1](C(=O)NC[C@@H1]2CCOC2)N(C)CC3=NC4=CC=CC=C4[NH1]3)=C1 CCC[C@H1](C)C(=O)NC1CCC2(CC1)CN(C(=O)[C@@H1](C)C=3C=CON=3)C2 O=C(NC1=CC=C(NCCN2CCOCC2)C=C1)NC3=C(F)C=CC(F)=C3F CC=1OC=NC=1C(=O)NC[C@H1](CNC(=O)[C@@H1](C)CC2=CC=CO2)S(C)(=O)=O CCC[C@H1](C)C(=O)N[C@H1](CCC1=CC=CC=C1)[C@H1](C)N=C2C=CC3=C([NH1]2)CCC3 CC1=NN(C)C(N)=C1C(=O)NCC[C@@H1](C)NC(=O)CCCCCS(N)(=O)=O CCC1=NC=CC=C1C(=O)NC[C@@H1](NC(=O)[C@@H1]2C[C@H1]2C3CCCCC3)C4CC4 O=C(NC1CN(C(=O)[C@H1]2CCCC23CC3)C1)C4CCC5(CC4)CC5 NS(=O)(=O)C1=CC(C(=O)N2CC3CC2(CNC(=O)[C@@H1]4CCC(=O)N4)C3)=CO1 CN(C)[C@@]1(C)CCCN(C2=NC(=N[C@@H1]3CCC(C)(C)C3)[NH1]C=4N=CN(C)C2=4)C1 C#CC1=CN(C)N=C1C(=O)N[C@H1]2CC[C@H1]2NC(=O)C3=CC=CC(OCCC)=C3 CP(C)(=O)CCC(=O)N[C@@H1](CNC(=O)[C@@H1]1CCCOC1)C2CC2 CC[C@@H1]1[C@@H1](C(=O)N2C[C@H1](NC(=O)/C=C/C(C)(C)C)C3(CCOCC3)C2)CCN1C CC1=CC2=C(C(C(=O)N[C@H1]3C[C@@H1]3CNC(=O)C4(O)CCC(C)(C)CC4)=C1)CCC2 CC1=CC=C(C=CC(=O)N[C@@H1](C)[C@H1](C)NC(=O)C2=NC(=O)N(C)[NH1]2)O1 COCCSCC(=O)N1C[C@@H1]2C[C@H1](C1)C2NC(=O)C[C@]3(C)CC3(F)F CC=CCC(=O)N1CC[C@]2(C[C@@H1]2C(=O)N[C@@H1](C)[C@@]34CC[C@@H1](CO3)C4)C1 CC[C@@H1](COC(F)(F)F)NC(=O)C1=CC=C2C(=C1)CCCC(=O)N2 COCC(C)(C)N1CCN(CNC(=O)OC(C)(C)C)CC1 CCCN(C(=O)CNC(N)=O)C1CCN(C(=O)C2=CC=CN=C2)CC1 CC(C)C=1SC=NC=1C(=O)NC[C@H1](O)CNC(=O)CC2=CC=NC(C(F)(F)F)=C2 COC1=N[NH1]C(C(=O)N[C@H1]2CO[C@@H1]3[C@@H1](NC(=O)CSC4CC4)CO[C@H1]23)=C1Cl O=CN1CCCN(C2=NC=NC3=C2N=CN3[C@H1]4C[C@@H1](OC5=CC=CC=C5)C4)CC1 CCN(CCCNC(=O)C=1OC2=CC=CC=C2C(=O)C=1C)C(=O)[C@@H1]3C[C@]3(F)Cl CC1=CC=C2C(=C1)C[C@H1](C(=O)N3CC[C@H1](NC(=O)C=4C=NOC=4)C5(CCC5)C3)O2 O=C(N[C@H1]1CC[C@H1]1NC(=O)C2=CC=CC(F)=C2F)C3=CN=CC4=C3CCC4 CCC1(C(=O)N2CC[C@H1](C)[C@@H1](CNC(=O)C3=CC=NC4=CC=C(N)C=C34)C2)CC1 CSC[C@H1]1CCCN1C(=O)C[C@H1](O)CNC(=O)C=2C=C[NH1]C=2 CCC[C@H1]1CCCN1C(=O)[C@H1](CC(C)(C)C)NC(=O)C2=CC(OC)=CS2 CC[C@H1](CC(=O)NC[C@H1](C)NC(=O)C1=CC=CC=C1OC(F)(F)F)C(C)C O=C(NCC1=CC(O)=NC(CNC(=O)C(C2CC2)C3CC3)=N1)C4(CO)CCCC4 CN(CC(=O)NC[C@@H1](NC(=O)COCC(F)F)[C@@H1]1CCOC1)C2=CC=CC=C2 CC1(C)CCCCCN1S(=O)(=O)N2CC(O)(C3=CC=C(Cl)C=C3)C2 CC1=CN=C2N1CCC[C@H1]2C(=O)N3CC[C@H1](CCNC(=O)C4=CC(Cl)=NS4)C3 COC1=CC=C(NC(=O)[C@H1]2CCCCN2C(=O)C3=CC=4C=C[NH1]C=4C=N3)C=N1 CC[C@H1](C(=O)NCCCC1C=CC(I)=C1Br)C2=CC=C(Cl)C=C2 COC1=CN=C(Cl)C=C1C(=O)N(C)C[C@H1](C)N(C)C(=O)COC[C@@H1]2CCCO2 COCC=1C=C(C(=O)NC[C@@]23CCCC[C@@H1]2CN(C(=O)C(C)(C)CO)C3)ON=1 CCSC1CCC(C(=O)N2CC(NC(=O)C3CCC4(CC3)CC4)C2)CC1 CCCN1N=C(C)C=C1C(=O)N[C@H1]2CN(C(=O)C=3C=NN(C)N=3)C[C@H1]2C CC1=CN=C(C(=O)NC[C@@H1](C)CNC(=O)C[C@@H1]2C=NN(C)C2=O)C(C)=C1 C=CCC(CC=C)C(=O)N1CCC[C@H1](C2CN(C(=O)C3=C[S@@](=O)CCC3)C2)C1 COC[C@]1(C(=O)NC[C@@H1]2CN(C(=O)C3=CC=NN3CC#N)[C@H1]4C[C@@H1]42)CCOC1 CC(C)(C)[C@@H1](C#N)C(=O)NC/C=C/C(=O)N1CC[C@@H1](OCCO)C1 CC[C@@H1](CC(=O)N1CC[C@H1](NC(=O)C2(O)CCCCCC2)C[C@H1]1C)C3CC3 C#CCN(CC1CC1)C(=O)[C@@H1](C/C=C/C)NC(=O)C=CC2CCCCC2 CC=1OC=CC=1CC(=O)N[C@@H1]2C[C@@H1]2CNC(=O)C3=CN4C=C(Cl)C=C(Cl)C4=N3 C=CCC(=O)N[C@H1]1CCCN(C(=O)C2=CC=C(NC(=O)NC(C)(C)C)C=C2C)C1 CNC(=O)CC(=O)N1CCC2(CC1)CN(C(=O)C3=CC(F)=CC(Cl)=C3)CCO2 COC1=CC(C(=O)N2C[C@@H1](NC(=O)C3=NN(C)C(C)=C3Br)[C@H1](OC)C2)=NC=N1 CC=C(F)C(=O)NC[C@]1(C)CCCN1C(=O)CC2=CC=CC(OCC)=C2 CC[C@@](C)(OC)C(=O)N[C@@H1](C)C1CCN(C2=CC(C(N)=O)=NC(Cl)=N2)CC1 NC(=O)C1=CN=CC(C(=O)N(CCCNC(=O)[C@H1](F)C(F)(F)F)C2CC2)=C1 NC1=CC=CC(Cl)=C1C(=O)NC[C@]23CCC[C@H1]2CCN3C(=O)CCOC4CC4 COCC1=CC=C(C(=O)N2CCCC[C@@H1]2[C@@H1](C)NC(=O)C(C)(C)C(C)(C)O)O1 CCOC=CC(=O)N1CC[C@@H1]2CCN(C(=O)CC3=CC=C(OC)C=C3F)C[C@@H1]2C1 O=C(CN1CCCC1)N2CCC[C@H1]2CCC3=CN(C4=CC(Cl)=CC=C4Br)N=N3 CCN(CC(=O)NC[C@H1](C)C1CC1)C(=O)CCC(=O)C(C)(C)C CCCC[C@H1](C(=O)N[C@H1](C)C1CC(NC(=O)C=2C=C(OC)N(C)N=2)C1)C(C)C CN(CCCCCNC(=O)[C@@H1]1NC(=O)[C@H1]2CC[C@H1]21)C(=O)CC3=CN=CN3C CC[C@](C)(CNC(=O)C1=CN(C)N=C1Br)NC(=O)[C@@H1]2CCOC2 C=C[C@H1](C)CCNC(=O)C1([C@H1](C)NC(=O)CN2CCSCC2)CC1 CCN(CC)C1=CC=C(C(=O)N(C)C2CC(NC(=O)CCN3CCCC3)C2)C=N1 CC=1C=C(C(=O)N[C@H1]2CC[C@H1]3CCN(C(=O)C4(O)CCC(C)CC4)[C@H1]2C3)OC=1C O=C(COC1=CC=CC(F)=N1)N[C@@H1]2C[C@@H1]2NC(=O)C=3C=C(Br)SC=3Cl CON=CC(=O)N1CC[C@@](O)(CN(C)C(=O)CCOC2CCN(C)CC2)C1 CC1=CC(C)=CC([C@@H1](C)C(=O)N[C@@H1]2CCN(C(=O)C3=CC(Cl)=CN3C)C2)=C1 C#C[C@H1]1CN(C(=O)[C@]23COC[C@H1]2CN(C(=O)C4=CC=CN4CCC)C3)CCO1 O=C(N[C@H1]1CC[C@@H1](NC(=O)C2CC(C(F)(F)F)C2)C1)C3=CC=CC=4SC=NC3=4 C[C@@H1](C#N)CNC(=O)[C@@H1]1CC[C@H1]1NC(=O)C[C@@H1]2CCCN(C)C2 COC1=NC=C(CN2CC[C@@H1]3[C@@H1]2CCCN3C(=O)CCC4CCCCC4)C=C1C CC1=NOC(CCC2CN(CC(=O)NCCC3=NN=CN3C)CC2)=N1 C[C@@H1]1[C@H1](O)CCCN1C(=O)[C@H1]2CCN(C(=O)C3=C(F)C=CC(C#N)=C3Cl)C2 COC1CC(CCC(=O)N(C)CCCCCNC(=O)CN2C=C(C3CC3)N=N2)C1 C#CCO[C@@H1](C)C(=O)NCC[C@H1](O)CNC(=O)C1=CN=C(N(C)C)N=C1 CCCC(C)=CC(=O)N[C@@H1]1CCN(C(=O)C2=CN(C)C=N2)C[C@@H1]1O NC(=O)CCNC(=O)C(=O)NCC1(O)CC(CNC(=O)C2(C3CCC3)CC2)C1 CCC(C)(C)CC(=O)N[C@]1(CF)CCN(C(=O)C2=COC(Cl)=N2)C1 CC[C@@H1](C)/C=C/C(=O)N[C@@H1]1CCN(C)[C@]12CCCN(C(=O)C=CC3CCCC3)C2 CCC1=CON=C1C(=O)N2C[C@H1](C(=O)NCC[C@H1](C)F)C3(CC3)C2 C#CC1(C(=O)NCC2(C)CC(C)C2)CCN(C(=O)CCC3=NC(C)=NO3)CC1 CC1=NOC2=NC(C(=O)N[C@@H1](C)[C@H1](NC(=O)C3=CC=C(O)N=N3)C(C)C)=CC=C12 CC(=O)C1=CC=C(S(=O)(=O)NC2CC(NCC3=CC=C(O)C(C#N)=C3)C2)C=C1 CCC(CC)(CNC(=O)C1=CN=C(C2CC2)N=C1O)NC(=O)C=CC3=CSC=N3 C1[C@H1]C(=CC2=CC=CC=C2F)N1CC3=CSC([C@H1]4CCS(=O)(=O)C4)=N3 O=C(CSCC1=CC=C(Cl)S1)NC[C@H1]2CN3CCC2CC3 C[C@H1](C(=O)N1CC[C@H1](C(=O)N2C[C@H1]3COC[C@@H1](C3)C2)C(C)(C)C1)N4CCNC4=O O=C(N[C@H1]1CCC12CN(C(=O)C3([C@@H1]4CCCO4)CCC3)C2)C5=CN=C(Cl)S5 CN(CCS(=O)(=O)NCC1CC1)C2=NC(Cl)=C(Br)C=C2F CN(C)C[C@@H1](O)CC(=O)N[C@H1]1C[C@@](C)(NC(=O)CN2C=CSC2=N)C1 C#CC[C@]1(C(=O)NCC(C)(C)C(F)F)CCN(C(=O)C2=CC=C(C)N=C2)C1 CC(C)CC[C@@H1](NC(=O)[C@@H1]1CCC[C@H1](CF)C1)C(=O)N[C@H1]2C[C@@H1]2C3=CC=CO3 CCC(C)=C(C)C(=O)NCCOCCN(C)C(=O)C[C@@H1]1CCC[C@H1]1C C[C@@H1](CF)CC(=O)N(C)CCNC(=O)C1=CC=C(C2=CC=C3C(=C2)OCO3)S1 COC=1C=C(C(=O)N2CC[C@](C)(CNC(=O)CN3CCSCC3)C2)SN=1 CC(C)(C)OC(=O)C1(NC(=O)[C@@]2(O)CC3CC2C3)CCCC1 CSC1=CC=C(C(=O)N([C@H1]2CCC[C@@H1]2O)[C@H1]3CCNCC[C@@H1]3C)C=C1 CC1=CC=C(NC(=O)[C@@H1](NC(=O)[C@H1](C)C2(O)CCC2)C3=CC=NN3C)C=N1 CC1=NC=CN=C1C(=O)N2CC[C@H1](C(=O)N(C)CC3=NC=C(C)O3)C2 COC[C@]1(C(=O)N2CC(OCCNC(=O)C3CC3)C2)CCCOC1 C[C@@H1](C(=O)NCC[C@H1]1CCN(C(=O)[C@H1]2CC[C@](C)(O)CC2)C1)C3=CC=C(F)C=C3 O=C(N[C@@H1]1COC[C@H1]1O)[C@@H1]2C=CCN2C(=O)C3=CC=C(N4CCCC4)C=C3 CC1=NO[C@H1](C(=O)NC[C@@H1]2COC[C@H1]2NC(=O)CCC(C)(F)F)[C@H1]1C FC1=CC=CC=2C(=NCC=3C=NN(CC4CCC4)C=3)[NH1]C(=NCC(F)(F)Br)[NH1]C1=2 CNC(=O)C1(CNC(=O)[C@H1]2CCC3=C(N=CN3C)C2)CC1 CCOC1=NC=CC(C)=C1C(=O)N[C@@H1](C)[C@@H1]2CCCN(C(=O)C3(C)CC(F)C3)C2 CC1=NC=2C=C(C(=O)N3C[C@H1]4C[C@H1](NC(=O)[C@H1]5C[C@@H1](N(C)C)C5)C[C@H1]4C3)[NH1]C=2S1 COC(=O)CC1=CC(C(=O)NC[C@@H1]2C[C@H1]3CN(C(=O)C[C@@H1](C)F)C[C@@H1]23)=NO1 CCCCC[C@H1](CC)C(=O)N(C)C[C@H1](O)CN(C)C(=O)C1=CC(C(F)(F)F)=NO1 CO[C@@H1]1CCC[C@H1](N(C)C(=O)[C@@H1](N)CC2CC(F)(F)C2)C1 C[C@@H1](CC(=O)O)CN1C=C(CCN(C)C(=O)CN2C=CC=CC2=O)N=N1 O=C1OCCN1CCC2=CN(C3CC4(C3)CC(NC(=O)[C@@H1]5CCCSS5)C4)N=N2 O=C(C[C@@H1]1CCCO1)N2CCC(C3(CC(=O)O)CCC3)CC2 CSC1=CC(C2=NC([C@@H1]3C[C@H1]3C)=NN2C=4C=NN(C)C=4)=CC=C1[N+1](=O)[O-1] CC=1N=COC=1C(=O)NC23CC(CNC(=O)CCO[C@H1]4CCCOC4)(C2)O[C@H1]3C CCC1=CC(Cl)=CC=C1C(=O)OCC2=CN=CC(C3=NN=NN3C)=C2 CC1=CC=C(CCC(=O)N2CC[C@](CNC(=O)[C@@H1](NC=O)C(C)C)(C3CC3)C2)O1 CC(C)C[C@@H1](C)C(=O)N[C@@]1(CNC(=O)C=CC2=NN=C(C(C)C)O2)CCOC1 C[C@@H1](CC(=O)N1CCC[C@H1]1CNC(=O)C2=CC=CC([N+1](=O)[O-1])=C2I)CC(C)(C)C CCC1=CON=C1CC(=O)NC[C@]2(F)CCCN(C(=O)[C@H1](SC)C(C)(C)C)C2 O=CC1OCC2(CN(C(=O)C(F)CN(C(=O)CCC(F)(F)C3(O)CCCC3)C)C2)N1 COCC[C@H1](CNC(=O)CCC1=CC=CC=N1)NC(=O)CCC2=CC=CC=C2F CC[C@@H1]1CN(C(=O)[C@@H1](O)COC)C[C@@H1]1NC(=O)CN(C)C C[C@]1(CNC(=O)[C@H1]2C[C@@H1](NC(=O)CN3CCC(F)CC3)CCO2)CCOC1 COCCOC1=CC=C(C(=O)N[C@H1]2CC[C@H1]2CNC(=O)C3=CC=CN=C3S)C=N1 C#CC[C@@](C)(CC)C(=O)N[C@@H1]1CC[C@H1]1NC(=O)C2=CC(OC)=CC(C)=C2N CC1=C(F)C=CC=C1C(=O)NCCCOCCN(C)C(=O)C2=CC(Cl)=CC=C2F CC1=CC(O)=NC(C(=O)N[C@@H1](CNC(=O)CC2=CC=CN=C2)[C@@H1](C)C(C)C)=C1 CC1=CC(NC(=O)[C@@H1]2COCCN2C(=O)[C@H1](C)O)=CC(C)=C1C C=CCCCCC(=O)N[C@H1]1C[C@@H1]1CNC(=O)C2=C(OC)C=CN3C=CN=C3S2 O=C(CC1=CC=CO1)N[C@H1]2C3C[C@H1]4[C@@H1](C3)C24C(=O)N5CC[C@H1](N6C=CC=N6)C5 C=C1CC(C)(C(=O)NC[C@@H1](NC(=O)C2=CC(OC)=CC=C2C)C3CC3)C1 CC1=CC(C(=O)NC[C@](C)(CO)NC(=O)[C@H1](C)OCC2=CC=CC=C2C)=C(C)O1 CC1=CC(C(=O)NC[C@@H1]2CCCC[C@H1]2NC(=O)C3=C[NH1]C=C3C)=CC=C1C(C)C O=C(CCC1=CC=C[NH1]1)N2CC3=C(C2)CN(C(=O)C=4C=NN(CCF)C=4)C3 CC1=NO[C@H1](C(=O)NC[C@H1]2CN(C(=O)C3(CO)CC(F)(F)C3)CC24CCC4)[C@H1]1C CC1=C[NH1]C=C(C(=O)N2C[C@H1](CNC(=O)[C@@H1]3COCCO3)C4(CC4)C2)C1=O C[C@H1](CC1CCC1)C(=O)NC[C@@H1](CNC(=O)[C@H1]2CCC[C@H1](F)C2)S(C)(=O)=O CCC=1C=C(CC(=O)N2CC(=C(F)CNC(=O)C3=C(C)S(=O)(=O)CC3)C2)N(C)N=1 COC(=O)C1CCN(C(=O)NC2=CC=C(S(=O)(=O)N3CCCCC3)C=N2)CC1 CCN1N=CC=C1C(=O)N2CC[C@@H1](C3CC3)[C@H1]2C(=O)NCC=4N=NN(C)C=4C C[C@@H1](C(=O)N1CCC[C@@H1]([C@H1](C)C(=O)N2CCO[C@H1]3COC[C@H1]32)C1)N4CCOCC4 CN1CCOC[C@H1]1C(=O)NC[C@@H1]2C[C@H1]3CC[C@H1]2N(C(=O)C4=CC(O)=NN4C)C3 O=C(NCC1=CN=CC(Cl)=N1)[C@@H1]2CC[C@@H1](NC3=NC=CC(N4CCOCC4)=N3)C2 CN(C[C@H1]1CCCN1C(=O)C2CC3(CC[C@H1]3O)C2)C(=O)C4=CN=C5C=C[NH1]C5=C4 NC(=O)NCC(=O)N1[C@H1]2CC[C@@H1]1C[C@H1](NC(=O)C=CC3=CC=CN=C3)C2 CN(C)C1=CN=C(C(=O)N[C@H1]2CCN(C(=O)C3=NC=C(F)C=C3F)C[C@H1]2CO)C=N1 COCCNC(=O)C(=O)NC[C@@]12CC[C@@H1](C1)N(C(=O)[C@H1]3CC[C@H1]4C[C@H1]4CC3)C2 CCN1C=C(C(=O)N2CCCC(NC(=O)C3CC(C(C)C)C3)CCC2)C=N1 C=C[C@@H1](CCC)CC(=O)NCCCCNC(=O)[C@H1]1CCN(C2=CC=CC=C2)C1 C#CCC(C)(C)C(=O)N[C@H1]1CCCC[C@H1]1N(C)C(=O)/C=C/C(F)(F)F C#CC1=CC=C(OC)C(C(=O)N[C@@H1](C2=CC=CC=C2)C3=CC=CO3)=C1 C[C@H1]1CC[C@H1](C)N1CC(=O)NCCCN(C(=O)C2CCSCC2)C3CC3 C[C@H1](CNC(=O)[C@@H1]1CC[C@H1]1C2=CC=C(F)C=C2)NC(=O)C3=CC(C(F)F)=NC=N3 C=CC[C@]1(NC(=O)C2=CN=NS2)CCCN(C(=O)C3=CC=CC=4N=C(C)[NH1]C3=4)C1 CCN1CCC[C@@H1]1C(=O)NCC[C@@H1](O)CNC(=O)CS(N)(=O)=O CO[C@]1(C(=O)NCCOCCCN(C)C(=O)C2=NC=CC=C2F)CCCOC1 CCCC1=NSC(N)=C1C(=O)N2CC[C@H1]([C@@H1]3CCN(C(=O)C4=CC=C(C)S4)C3)C2 O=C1C[C@H1](C(=O)NCCCOCCNC(=O)C2C[C@@H1]3CCC[C@H1]3C2)CCN1 C[C@@H1](C(=O)N(C)CCNC(=O)CCC1=CN(C)N=N1)C2CCC2 C[C@@](O)(C(=O)N[C@@H1]1C[C@H1]1NC(=O)C2=CC=C(CN3CCCC3)C=C2)C4CC4 CC1=CC=C(C(=O)N2CC[C@@](CO)(NC(=O)CC3=N[NH1]C(C)=N3)C2)C=C1O C=CCC(=O)NC[C@H1]1CN(C(=O)[C@H1](OC)C2=CC=C(F)C=C2)CC(C)(C)O1 CCCC(CCC)CC(=O)N(C)C[C@@H1](C)CNC(=O)C(C)(C)NS(C)(=O)=O CCC(CC)(CNC(=O)[C@@H1](C)CF)NC(=O)C=1C=C(C2=CN(C)N=N2)ON=1 C=C[C@@](C)(O)CC(=O)NC[C@H1]1C[C@H1](O)[C@H1](O)C[C@H1]1C(=O)N(C)[C@@H1]2CCSC2 O=C(N[C@@H1]1CN(C(=O)C=2C=CC3=NN=NN3C=2)[C@H1]4CCCC[C@H1]14)C5CC(F)(F)C5 CC1=CC=C(C(=O)N2CC[C@@H1](C)[C@@H1](N(C)C(=O)C3=CN(C)C=N3)C2)C=C1CO CS[C@@H1]1CN(C(=O)CCC(=O)N(C)C)C[C@H1]1NC(=O)C(C)(C)OC(C)C O=C(NC[C@@H1]1CCN1CC=2C=CN(C3CCCC3)N=2)C4=CC=C[NH1]4 CC1=C[NH1]N=C1C(=O)N2C[C@@H1](NC(=O)C3=NC=C(F)C=C3F)[C@H1](S(C)(=O)=O)C2 CCC[C@@H1](CC)C(=O)N1C[C@H1](CNC(=O)C(C)(C)C2=CC=C(O)C=C2)[C@@H1](C)C1 CCOCC[C@H1](NC(=O)C1=CC=CC(F)=C1C)C(=O)N2CCC[C@@H1]2CC3CCC3 CC=1C=CSC=1C=CC(=O)N[C@H1]2C[C@@H1](OCC(=O)N(C)CCOC3CC3)C2 CC1=NOC(CCNC(=O)C2(NC(=O)[C@@H1]3CNC(=O)C[C@@H1]3C)CC2)=N1 CS(=O)(=O)CCNC(=O)C[C@@]12CC[C@@H1]1CN(C(=O)C3=CN(CCO)N=N3)C2 COC1=CC=C(C(=O)N2CC(NC(=O)C=3C(C)=NN(C)C=3Br)C2)C(N)=C1F C[C@H1]1CN(C(=O)C=CC2CC2)CCN1C(=O)[C@H1]3C(F)(F)C34CC4 CC1=NC=C(Cl)C(C(=O)N[C@H1]2CC[C@](C)(CNC(=O)C3CC(C(C)C)C3)C2=O)=N1 N=C1N=CN=C(N2CC[C@H1](NC(=O)C[C@@H1]3CC[C@@H1]4C[C@@H1]4C3)C2)[NH1]1 C=C[C@@H1]1OCCC[C@H1]1C(=O)NC[C@@H1](C)CNC(=O)C2=CN(C)N=C2C3CCC3 CCS[C@H1](C)C(=O)NC[C@@]1(C)CN(C2=CC=NC=C2C#N)CCO1 CN(CCS(C)(=O)=O)C1=CC=C(S(=O)(=O)N2CCO[C@H1](C(F)(F)F)CC2)C(Br)=C1 C[C@H1](C(=O)N1CC2(NC(=O)C3=CC4=CC=CC(Cl)=C4[NH1]3)CC1C2)C5=CC=CC=C5 CCN(CCCNC(=O)C1=CC=2C=CSC=2C(O)=N1)C3=NC(C(C)C)=NS3 CC(C)[C@@H1](O)C(=O)NCCNC(=O)C(C)(C)N1C=NN=N1 O=C([C@H1](F)CC1CC1)N2CCC[C@H1]([C@@H1]3CCN(C(=O)C=4N=CSC=4C5CC5)C3)C2 CNC(=O)N1CC(C(=O)NCC2CN(C(=O)CC3=CN=C4C(=O)[NH1]C=CN34)C2)C1 C[C@@H1]1CN(C(=O)[C@@H1]2CN(C(=O)[C@H1](C)C3(O)CCC3)CCC2(C)C)C[C@H1](CO)O1 CCCCN(C)CCNC(=O)CC(C)(C)CNC(=O)[C@@H1]1COCC1(C)C COC(=O)N1CCC[C@H1]1C(=O)N[C@H1]2C[C@H1](NC(=O)C3(C)C(C)(C)C3(C)C)C2 CC1=NC=C(C)C(N[C@H1](CNC(=O)CC2=CC=CC=C2F)C3CCC3)=N1 CCCN(C1=CC=CC(Cl)=C1[N+1](=O)[O-1])[C@@H1](C)C2=CC=C(C(F)(F)F)C=C2 CC[C@H1](CCC(=O)NCC1=CC(C(=O)N[C@H1]2CCN3CCCC[C@@H1]23)=CS1)OC CC1=NN=C(CN(C)[C@H1](C(=O)NC2CC2)C3=CC=CC(Br)=C3F)S1 COC1=CC(Br)=C(F)C=C1[C@H1](C(=O)NCCC2CC2)N3CCCC[C@@H1]3CCCO CCOC(=O)C1=C(NC(=O)C2=CC(NCC3=CN=CO3)=CC=C2Cl)CCC1 C=CC1(CC(=O)N2C[C@@H1](OC)C[C@@H1](NC(=O)[C@@H1](C)CN(C)C)C2C)CCC1 C[C@H1](NC(=O)C1=CC2=CC(Cl)=CC=C2O1)[C@H1]3CCCN(C(=O)C4=CC(C)(C)C4)C3 CC1=CC=C(C(=O)N2CCC[C@H1]3[C@H1]2CCCN3C(=O)CN4CCCC4=O)N1C CC(C)(F)CCC(=O)N1CC[C@@](F)(CNC(=O)[C@@]23COC[C@@H1]2C3)C1 C#CC1=C[NH1]N=C1C(=O)N2CC[C@@H1](N(C)C(=O)C3=C[NH1]C4=C(C#N)C=CC=C34)C2 C[C@@H1]1CN(C)CCN(S(=O)(=O)C2=C[NH1]C=CC2=NCCC3=NC=CN3C)C1 C=C(C)C[C@H1](NC(=O)C[C@@](C)(O)CCC)C(=O)N[C@H1]1CCO[C@@H1]1C2CC2 C[C@H1](C(=O)NC1CCC2(CC1)CN(C(=O)CC3(C#N)CC3)C2)C4=CC=C(Cl)C=C4 C[C@H1]1CC[C@@H1](C(=O)N(CC#N)CC#N)N1CC=2C=CN(C3=C(F)C=CC=C3F)N=2 CC1(C)C[C@@H1](NC(=O)CNS(C)(=O)=O)CN(C(=O)C2=NSC3=C(Cl)C=CC=C23)C1 C#CCOC(=O)C=1N=C(C2=CC=CC=C2OC)N(CC3=CC=CS3)N=1 CCN(C)CC(=O)N1CCC[C@]2(CCCN2C(=O)[C@H1](F)N3C=CC=N3)C1 C#CCC(CC#C)C(=O)N1CC(CNC(=O)C23CCN(CC2)CC3)(C(N)=O)C1 O=C(N[C@@H1]1CCOC[C@H1]1O)[C@H1]2CC23CCN(C(=O)[C@H1]4C[C@@H1]5C=C[C@H1]4C5)CC3 C[C@H1](CC(=O)NCCCN1CCN(C(=O)[C@@H1](F)OC(F)(F)F)CC1)CC(C)(C)C C#CC[C@]1(O)C[C@@H1](C(=O)N2CC[C@@H1](N3CCN(CC4=CC=C(Br)C=C4)CC3)C2)C1 C#CC[C@@H1](O)C(=O)NC[C@H1](CC(F)(F)F)NC(=O)CN1C=C(C(N)=O)C=CC1=O O=C(N[C@H1]1CC[C@H1](CNC(=O)C2=CC=C(Br)C=N2)CC1)C3=NC=CC=N3 C[C@H1](CCNC(=O)C1=CC(Cl)=CC=C1N)N(C)C(=O)C2=CC=NC(O)=C2 C[C@H1](CC(=O)N[C@H1](CO)CN(C)C)N(C)C(=O)C1=CC=C2C=CC=NN12 COC1=CN=CC(C(=O)NCCC(=O)N=C2C=CN(CCCO)[NH1]2)=N1 CC(C)N(C)C(=O)C1(C(=O)NC[C@H1]2[C@@H1]3CN(C(=O)C[C@]4(C)CCOC4)C[C@H1]23)CC1 CCC(=O)NNC(=O)C[C@@H1](C)N(C)C(=O)OC(C)(C)C CCC(C)(C)CC(=O)NC[C@H1](C(=O)N1CCC[C@H1]1[C@@H1](O)CO)C(C)(C)C CN1N=NC(CNC(=O)[C@@H1](C2=CC3=C(Br)C=CC=C3O2)N(CC#N)CCC#N)=N1 O=C(NCC1CN(C(=O)[C@@H1]2OCCOC23CCC3)C1)C4=CC=CC5=NN=CN45 C=C(Cl)CONC(=O)C[C@@H1](NC(=O)C=1C=CN(C(C)C)N=1)C2CC2 CC12CC(C(=O)NC3CC(CNC(=O)[C@@H1]4CCCC5=C4N=CN5C)C3)(C1)C2 O=C(N[C@@H1]1CCCN(C(=O)C2=CSCCO2)CC1)C3=CC=CC(C(F)F)=N3 CCCCCCCCCCS(=O)(=O)N1C[C@@H1]2CN(C(=O)C3(F)CCC3)C[C@@H1]2C1 CCN1N=CN=C1C(=O)N2C[C@@H1](NC(=O)C(=O)N3CC[C@@H1](C)C3)[C@H1](CC4CC4)C2 ClC1=CC=C(N2CCC(CCN=C3[NH1]C=CC4=N[NH1]C=C34)CC2)C(Cl)=C1 CO[C@H1]1C[C@@H1](NC(=O)C=2C=CON=2)CN(C(=O)[C@H1]3C[C@@H1](C4=CC=C(O)C=C4)C3)C1 CSC=1SN=NC=1C(=O)N2C[C@H1]3[C@@H1](CNC(=O)CCN4C=CN=C4)CCC[C@H1]3C2 CN(C)CC1=CC=C(C(=O)NC[C@@H1]2CN(C(=O)CN3C=CC=C3)CCO2)O1 CSCCOCC(=O)N[C@H1]1CCOC[C@H1]1NC(=O)C=C2CCN(C)C2 CCC(C)(C)CCCC(=O)N1C[C@H1]2[C@@H1](N(C)C(=O)[C@H1]3CCN(C)C3)CC[C@H1]2C1 C[C@H1](NC(=O)CCN(C)C(=O)CN1N=CN=N1)C2=CC=CC(F)=C2 CC[C@H1](O)[C@@H1](C)C(=O)N1CCCC[C@H1]1CNC(=O)C2=COC(CO)=C2 CN(C)CCOCCNC(=O)[C@H1]1CN(C(=O)C2=CCCC2)CC(C)(C)C1 CCOC(=O)CCC(=O)N1CCC(C)(C)[C@@H1]1CNC(=O)C=2SC=CC=2CC C[C@H1](NC(=O)[C@H1]1C[C@H1]1C)[C@H1]2CCCN2C(=O)[C@@H1]3CN4CCN3CC4 C#CCC[C@H1](NC(=O)[C@@H1](C)NC(=O)C1CC1)C(=O)NCC2=CC=C(F)C(O)=C2 CC(C)CC(=O)C(=O)NC1CC2(C1)CC(C(=O)N[C@@H1]3CCC[C@H1](C4CC4)C3)C2 CC=1C=NSC=1C(=O)NCCCC(=O)N(C)CCP(C)(C)=O CO[C@@]1(C(=O)N(C)CC2(NC(=O)[C@@H1](OC(C)(C)C)C(C)(C)C)CC2)CCCOC1 O=C(CC1OCCO1)NC[C@H1]2CCN2C(=O)C=3C=C(C4CCOCC4)ON=3 CC[C@@H1](C)CCCCC(=O)NCC(C)(C)CNC(=O)CNS(=O)(=O)N(C)C COC[C@H1](C)[C@@H1](C)C(=O)N[C@@]1(CNC(=O)C2=CSC3=CN=CN23)CCCC[C@@H1]1C CC(C)C1=CC=CC=C1OCC(=O)N[C@H1]2CC23CC(NC(=O)[C@@H1](F)C(C)C)C3 CC1=CC=CC(C(=O)N[C@H1](C)C2(O)CN(C(=O)C3=CC=CN=C3C(C)=O)C2)=C1N NC(=O)NC1(C(=O)N2CC[C@]3(CCN(C(=O)/C=C/S(F)(F)(F)(F)F)C3)C2)CC1 CCC[C@@H1]1CN(C(=O)C2COC2)CCN1C(=O)C[C@H1]3CCCC3(F)F CC=1OC(Br)=CC=1C(=O)N2CC[C@@H1]3[C@@H1](NC(=O)C4=CC(O)=NC(O)=N4)[C@@H1]32 CCCCCCCCOCC(=O)N[C@H1]1C[C@H1]2C[C@H1]1N(C(=O)CC(C)(C)CC)C2 CCOC1=NC(C(=O)NCC23CC(NC(=O)[C@]45CCC[C@H1]4C5)(C2)C3)=CO1 CC(=CC(=O)N1CCN(C(=O)COC=2C=CSN=2)[C@@H1](C)[C@H1]1C)C(C)(C)C CC1=CN=CC(C)=C1C(=O)N2CC(C3(NC(=O)C4=CC=CC5=NC=CN45)CC3)C2 CCN1CCCC[C@@H1]1C(=O)NC[C@H1]2CCN(C3=NC(Cl)=NC(C)=C3F)C2 C#CC1CN(C(=O)COC2CN(C(=O)CC3(O)CCCCC3)C2)C1 CN1C(C#N)=CC=C1C(=O)NC[C@H1]2CCC[C@H1]2C(=O)N3C[C@@H1](F)C[C@H1]3CO C[C@H1](O)C(=O)N[C@@H1]1C[C@H1]2CN(C(=O)C3=CC=C4CC(C)(C)CC4=C3)C[C@@H1]21 CC1=NN(C)C=C1CCC(=O)NC[C@H1](C)CN(C)C(=O)CN(C)C2CCCC2 CC(C)[C@@H1](C)[C@@H1](CNC(=O)CC(C)(C)F)NC(=O)C1=CC=CC=2[NH1]N=CC1=2 CCN1C=C(C(=O)NC2(C)CC(NC(=O)[C@H1]3CCSC3)C2)C(C(F)(F)F)=N1 CC1=CON=C1CC(=O)N2CC[C@H1](CO)[C@H1](NC(=O)C[C@@H1](O)C3CCCC3)CC2 CN1C=CC=C(C(=O)NC[C@H1]2C[C@@H1]2NC(=O)C=3[NH1]N=C(C(F)(F)F)C=3C)C1=O CCC[C@@H1](NC(N)=O)C(=O)N1CC(C[C@@H1](C)NC(=O)C2=CC=3SC=NC=3[NH1]2)C1 CC=CC=CC(=O)N1CCC2(C1)CN(C(=O)C[C@H1]3CC[C@H1](C#N)C3)C2 CCC(C)(C)NC(=O)[C@H1](C1=CC(Cl)=CC(Cl)=C1OC)N(C)[C@H1](C)C=2C=C(C)ON=2 O=C1N[C@H1](C(=O)N[C@@]23CCN(C(=O)C4=CN=C(C5CCC5)S4)CC[C@H1]2C3)C[C@@H1]1F O=C(NCC[C@@H1]1CSCCN1C(=O)C[C@@H1]2CC[C@H1]3C[C@@H1]23)[C@@H1](O)C4=CC=CC=C4 CNC(=O)N1CC(C(=O)N2CC[C@H1]3CCCN(C(=O)COC(C)=O)[C@@H1]3C2)C1 CC[C@@H1](OC)C(=O)N(C)CCNC(=O)C1=CC(C)=CC2=C(C)C=CN=C12 O=C(NCC1(C(=O)NCC2CC3=CC=CC=C3C2)CCCC1)C4CC(O)C4 C[C@H1]1C[C@@]2(CCN(C(=O)NCC3=NN=C(C(F)F)S3)C2=O)CO1 C=C1[C@H1](C(=O)OC)[C@H1]1C(=O)N2CC[C@](O)(CNC(=O)CC=C(C)C)C2 C=CC[C@@H1](CNC(=O)[C@](C)(O)COC)NC(=O)C1=CC(O)=NC(CC(C)C)=C1 CCCCCCCCCC(=O)N1C[C@@H1]2C[C@]2(NC(=O)C[C@@H1](C)C(C)C)C1 CC1=CC=CC(C(=O)NC[C@@]23C[C@@H1]2CN(C(=O)C4=C[NH1]N=C4C(C)(F)F)C3)=C1O CCS(=O)(=O)N1CC(C(=O)N[C@H1]2C[C@@H1]2NC(=O)CC3(O)CCCCCC3)C1 CCN=C1[NH1]C=C(C(=O)N[C@@H1]2C[C@H1]3C[C@H1]2CN(C(=O)CCC4=CN=C[NH1]4)C3)S1 COCC1=CC=NC(C(=O)N[C@H1]2COCCN(C(=O)CN3CSCC3=O)C2)=C1 CC=1C=C(CNC(=O)C2=C(Cl)CCC2)OC=1C(=O)NC[C@@](C)(O)C(F)F CC[S@](=O)(=NC(=O)CCC=1C(C)=NOC=1Cl)C(C)C C[C@H1](C1=CC=CC=C1)N2N=NN=C2[C@@H1](NCC3(CO)CC3)C4=CC(Cl)=C(F)C=N4 CC1=CC(Cl)=C(C(=O)N(C)CCC(C)NC(=O)C2=C3C=C(C)C=CC3=CC=C2)S1 CCC(C)(C)CC(=O)N1CC[C@H1](NC(=O)C2=CC3=CC=CC=C3C=C2F)[C@@H1](F)C1 CC1=C(C)C[C@H1](C(=O)N2CC[C@H1]3[C@@H1](C2)[C@@H1]3C(=O)N[C@H1](C)C4=NN=CN4C)CC1 C=CCOCC(=O)N1C[C@@H1](NC(=O)CCCC2=CC=CC=N2)CC[C@H1]1C CC[C@H1]1C[C@@H1]1C(=O)N(CCC(=O)NOCC[C@H1](C)O)CC2CC2 O=C(COC=1C=CON=1)N[C@@H1]2C[C@H1]2CNC(=O)C3=N[NH1]C4=CC=C(Cl)C=C34 CCC[C@H1](C)NC(=O)[C@@]1(CNC(=O)[C@@H1](C)OCC(C)C)CCCO1 CC=CCONC(=O)[C@H1]1CCN(C(=O)C2=CC=CC(NC)=N2)[C@H1]1C(C)C CCC1=CC=C(OC)C(C(=O)N[C@H1]2CCC[C@@H1]2NC(=O)CN(C)C(=O)C(C)C)=C1 C[C@@H1](F)CC(=O)N1CC[C@@]1(C)CC(=O)NCC2=NO[C@H1]3COC[C@@H1]23 COC1=CC=C(Br)C(CC(=O)N[C@@H1](C)C2CN(C(=O)C=3N=NN(C)N=3)C2)=C1 CC(C)CC1=CC(C(=O)N2CC[C@H1](C)C[C@@H1]2CNC(=O)COC3CC(F)(F)C3)=NO1 CCCCC(=O)NCC[C@@H1]1CN(C(=O)CCC2=CN=C3N2CCCC3)C[C@H1]1C CN(CC(C)(F)F)C1=NC(N(C)CCCCN2CCCC2)=NC=3C=C[NH1]C1=3 CC(C)(O)C(=O)N1[C@H1]2CCC[C@H1]1CN(C(=O)C3=CC=C(C(F)(F)C(F)F)C=N3)C2 CCS[C@@H1](C(=O)N1CCC2(C1)CN(C(=O)C3=CC(F)=C(F)C(F)=C3)C2)C(C)C CC1=NC=C(C(=O)NCCNC(=O)C=CC2=COC=N2)C=C1N CC1=CC(C(=O)N[C@H1]2C=CCN(C(=O)C3=CC=C[NH1]3)C2)=C4C(C)=NOC4=N1 COC1=NC=C(S(=O)(=O)NC=2[NH1]C=NC=2C)C=C1F C[C@H1](C(=O)NCCCC(C)(C)NC(=O)CCCS(N)(=O)=O)C=1C=C[NH1]N=1 CCC1(O)CN(C(=O)[C@]23CCC[C@H1]2CCN3C(=O)CCOC(C)=O)C1 C[C@H1](CN1C=C(CCN2CCCSCC2)N=N1)NC(=O)[C@H1]3C[C@@H1]3C4=NC=CN4C C[C@@H1](NC(=O)[C@H1](C)S(N)(=O)=O)C1(CNC(=O)C=2[NH1]N=NC=2C3CC3)CC1 COCC(COC)C(=O)N1CCC[C@H1](N(C)C(=O)C2=CN=C3[NH1]C=NC=C23)C1 CCCOC1=CC=CC(CC(=O)N2CC3(CC(NC(=O)C4=C(C)CCC4)C3)C2)=C1 O=C(O[C@@H1]1C[C@H1](C2=CC=CC=C2)NC1=O)C3=C(Cl)N=C4C=CC(Br)=CN34 CO[C@@H1]1C[C@H1]1C(=O)NCCN(C)C(=O)C2(C(=O)N3CCCC3)CC2 C[C@H1](C(=O)N[C@H1](CNC(=O)[C@H1]1C[C@H1]1C)C2CCCC2)C3=CC=CC(F)=C3 CCCOCC1=CC=CC=C1C=2N=CSC=2C(=O)NCCN=C3C=CC(C)=C[NH1]3 C=C(CO)CCNC(=O)NCC(=O)C=1C=NN(C)C=1 CC(C)C(=O)N1C[C@@H1](NC(=O)CCF)CC12CCCC2 C[C@H1](CN1CCN(C(=O)C2=CC=CC(=O)N2C)CC1)NC(=O)C3(C)CC3 CCN1CCN(C2=CC(NCCNC(=O)C3=CC=CC=C3)=NC=N2)CC1(C)C C=CCN1N=NN=C1C2(N[C@H1]3CCO[C@](C)(CC)C3)CCC(F)(F)CC2 CCC1=NN=C(C(=O)NC[C@@H1]2CN(C(=O)C(C)=CC3=CC=CO3)C[C@@H1]2C)S1 CC(C)[C@H1](NC(=O)C1=CC(S(N)(=O)=O)=CO1)[C@@H1](C)NC(=O)C2=CC=C(C(F)F)S2 CC(=CC(=O)N[C@@H1]1CN(C(=O)C2(F)CC2)CC13CC3)C(C)(C)C CN(C)CCOCCC(=O)NC[C@]1(F)C[C@@H1](NC(=O)C2=CN=C3N2CCS3)C1 CC1(C)C[C@@H1](O)CN1C(=O)C=2N=CN3C=C(NC(=O)[C@@H1]4CCCO4)C=CC=23 COCCC(=O)N[C@@H1]1CCCN(C(=O)C2=CC=C([N+1](=O)[O-1])N2C)CC1 COC1=CC=C(C(=O)N2CC(CC(=O)NC[C@H1]3CC3(Cl)Cl)(OC)C2)S1 COC1=CC=C(Br)C=C1S(=O)(=O)NCCN2C=C(C3=CN(C)N=C3C(N)=O)N=N2 CCC=1OC=NC=1C(=O)NC2(CCC(=O)NCCN3CC(C)(O)C3)CCCC2 C[C@H1](NC(=O)C1CCC1)[C@]2(O)CCN(C(=O)C3=CN([C@@H1]4CCOC4)N=N3)C2 CC(=O)N[C@@H1](C)C(=O)N1CCC2(CC(NC(=O)[C@H1](CC(C)C)N(C)C)C2)C1 CO[C@H1]1CN(C(=O)CCCN2CCCC2)C[C@H1]1NC(=O)C3CC4(CCC4)C3 CCC1=CC=CC(C(=O)N2C[C@H1]3C[C@]3(CNS(=O)(=O)C4=CC(F)=CC=C4F)C2)=C1 CC=1N=C[NH1]C(=NC[C@H1]2CN(C(=O)[C@H1]3CCCN(C(C)C)C3)CCCO2)C=1Br CS(=O)(=O)CC=1N=C(C2=C[NH1]C=C(Br)C2=O)N(CC3=CC=CC=C3Cl)N=1 C#C[C@H1](CC)NC(=O)CC[C@@H1]1CCN(C(=O)C=2C=C(C(F)F)[NH1]N=2)C1 COC(=O)[C@@H1](NC(=O)C12CC(CO)(CN1C(=O)C3(SC)CCC3)C2)C4CC4 COC=1C=C(C(=O)N(C)CC(C)(C)C(=O)NCC2=CN=N[NH1]2)[NH1]N=1 COC1=CC=C(CCC(=O)N(C)[C@H1]2CCCN(C(=O)C34CC(F)(C3)C4)C2)C=C1 O=C1C[C@H1](C(=O)NC[C@H1]2C[C@]3(CCN3C(=O)C4=CN=C(NC5CC5)S4)CO2)N1 COC(=O)[C@H1](CNC(=O)C1(NC(=O)CCN2C=CN=C2)CCCC1)OC CCOCCOCC(=O)N1[C@H1](C(=O)N(C)C2CCN(OC)CC2)[C@H1]3CC[C@@H1]1C3 C=CCCO[C@@H1](C)C(=O)N(C)[C@@H1]1CCCCN(C(=O)C2=C(Cl)C=CC(F)=C2C)C1 COC1=NC=C(C(=O)N2CC[C@](CO)(CNC(=O)CC[C@@H1]3CCC(=O)NC3)C2)S1 CCCN(CCCO)C(=O)C1=CSC(CNC(=O)CC2(OC)CCC2)=C1 N#CC=1C=N[NH1]C=1C(=O)N2CCN(C(=O)C[C@@H1]3CCC[C@H1]3O)C[C@H1]2CC(F)F C[C@@H1]1CC=C(C(=O)N2C[C@H1](CNC(=O)C3=CC=C(O)N=C3Cl)[C@@H1](N(C)C)C2)CC1 CC1=CC(F)=CC(C(=O)N2CC[C@@](F)(C3=CN(C[C@@]4(F)CCOC4)N=N3)C2)=C1 CS[C@H1](C(=O)NC1(CO)CCN(C(=O)[C@H1](O)C2CCCC2)CC1)C(C)C COC[C@H1](C)C(=O)N[C@H1]1CN(C(=O)C2(CS(C)(=O)=O)COC2)CC(C)(C)C1 COC1=CC(C(=O)NCC2=CC=CC(Br)=N2)=C(C=3C=CC4=NSN=C4C=3)C=N1 C[C@H1](OCC(F)(F)F)C(=O)NC(C)(C)[C@@H1]1CCN(C(=O)CCC2CCCC2)C1 CSC1(CNC(=NCCC(C)=O)N2CCC[C@H1](S(C)(=O)=O)C2)CCC1 O=S(=O)(C1=CC=C(Br)C=C1)N(C[C@@H1]2CCNC2)C3=NC=C(I)C=N3 CC(=O)OCCC(=O)N1CCCN(C(=O)C2=NN(C)C3=C2CCC3)C[C@@H1]1C C[C@@]1(CN=C2[NH1]C3=C(C(=NCCCN4C=C(CO)N=N4)[NH1]2)COC3)CC1(Cl)Cl COC1(C(=O)NC[C@@H1]2CC3(CCN(C(=O)C4CCSCC4)CC3)CO2)CCCC1 CC1=CC(C(=O)NC[C@H1](C)[C@]2(O)CCN(C(=O)COCCN(C)C)C2)=CC(C)=N1 CN(C(=O)[C@@H1](CC=1C=C[NH1]N=1)NC(=O)CCCCC2CC2)[C@H1]3CCCOC3 CCN1CCC[C@@H1]1CC(=O)NC[C@@H1]2CCCN2C(=O)C3=CC(Br)=CN=C3S COCC(F)(F)C(=O)N1C[C@@H1](N(C)C(=O)[C@H1](OC)C2=CC=CC=C2)C3(CC3)C1 CC(=O)N1CC[C@@H1](C(=O)N2CC[C@H1](C(C)(C)NC(=O)C=C3CCC3)C2)C1 O=C(CCCN1C=C(C2=CC=C3C(=C2)CNCC3)N=N1)N[C@H1]4CCO[C@H1]4C(=O)O C[C@H1](N=C1C=CN=C(N)[NH1]1)[C@H1](O)C2=CC=C3C=CC=CC3=C2 COC1=C(C(=O)N2CCO[C@H1](C(=O)NCCSC3=CC=CC=N3)C2)C=CN=C1Cl COCCOCC=CC(=O)N1C[C@@H1]2CN(C(=O)C3=CN=CC(Cl)=N3)CC[C@@H1]21 C[C@@H1](CNC(=O)[C@H1]1CCOCC12CCCC2)NC(=O)C=3C=C4N(N=3)CCCN4 CN1N=NC=2C=C(C(=O)NC[C@]3(NC(=O)C[C@H1]4CC4(Cl)Cl)CCCC[C@H1]3C)SC=21 CCN1CC[C@@H1](C(=O)N[C@@H1](CO)CNC(=O)C2=CC3=C(C=C2Cl)NC(=O)C3)C1 CCC[C@H1]1CN(C(=O)CCS(=O)(=O)NC)CCN1C(=O)[C@H1]2CCCCC23CCC3 CC[C@H1]1CCN1C(=O)[C@H1]2CC(C3=C(F)C=CC=C3F)=NO2 CON=CC(=O)N1CC[C@](CNC(=O)CC2(N(C)C)CCCC2)(OC)C1 COC1(CC(=O)NCCC2(C)CN(C(=O)C=CC=3C=NN(C)C=3)C2)CCCC1 C#CCCCC(=O)NCCC1=CC=C(C(=O)NC2=CC=C(C#N)C=C2)C=C1 CCC[C@H1](NC(=O)C(C)(C)COCC)[C@H1](O)C(=O)N1CC2=CC=CN=C2C1 CCC1=CC(NC(=O)[C@@H1]2C=CCN(C(=O)[C@@H1]3CN(C)CCO3)C2)=CN=C1C CC1=CSC(C=CC(=O)NCCCN(C)C(=O)C2=CC=C(CC(N)=O)C=C2)=N1 CC(=O)C1=C[NH1]C(C(=O)NC[C@H1]2CCC[C@@H1]2NC(=O)[C@H1]3C[C@H1](O)CN3C(N)=O)=C1 CN=C1N=C(N2CC=CCC(C)(C)C2)[NH1]C(=N[C@H1](C)CC=3C=N[NH1]C=3)[NH1]1 COC1=CC=C(CN2C=C(CNC(=O)[C@@H1](O)C(F)(F)C3=CC=CC=C3)N=N2)N=C1 C[C@@H1](CNC(=O)C(C)(C)C1=CC=CC(C#N)=C1)NC(=O)[C@@H1](O)CCN(C)C CC(C)=C[C@@H1]1[C@H1](C(=O)NC(C)(C)CNC(=O)CN2N=NC(=O)[NH1]2)C1(C)C C=CC[C@@H1](CNC(=O)C1=CC=C(C)C=C1)NC(=O)C2=CC(C(F)F)=CC=C2Cl O=C(C1=CCCC1)N2CC(C3CCN(C(=O)C4=COCCC4)CC3)C2 COC1=NC(Cl)=C(C(=O)N(C)CC2CCN(C(=O)[C@H1](F)CC3CC3)CC2)S1 CC1=CC=C(CN[C@H1]2C[C@@H1](NS(=O)(=O)C3=CC=C(Br)C=N3)C24CCC4)C=C1Cl C[C@@H1](NC(=O)C(C)(C)N1C=NN=N1)C2=NOC=C2C(=O)N(C)C[C@H1](O)C3CCCC3 CCCN(C(=O)C1=CC=C[NH1]1)C2CCN(C(=O)[C@@H1]3CCC[C@@H1](F)C3)CC2 O=C(CC1=CCN(C(=O)[C@H1]2CCC2(F)F)CC1)NCC[C@H1]3CCOC3 CS(=O)(=O)C1=CC(C(=O)N2CC[C@]3(NC(=O)C4CC=CC4)CCCC[C@H1]23)=CC=N1 C#CC1=CC=CC(C(=O)N[C@H1]2C[C@H1](O)CN(C(=O)C[C@H1]3CCC(C)(C)O3)C2)=C1 C[C@H1](CN1CCCCC1)NC(=O)C#CC(=O)N(C)C C[C@H1](CCC(=O)O)NC(=O)N1CC[C@H1]2CC[C@H1]2C1 C[C@@H1]1C[C@@H1](CNC(=O)C2=CC=C(C(N)=O)S2)CCN1C(=O)CCC=3C=CSC=3 CCCSCC(=O)N(C1)C[C@H1]CN(C(=O)C[C@@H1]CCF)CC12CC2 O=C(N[C@@H1]1COCCN(C(=O)CC(F)(F)F)C1)[C@@H1]2C[C@@]23CCC4=CC=CC=C43 CC1(C)CN(C(=O)C2=CCCCC2)[C@H1](CNC(=O)C3CN(S(C)(=O)=O)C3)CO1 CC=1N=COC=1C(=O)N2C[C@@H1]3C[C@H1](NC(=O)CC4OCCCO4)C[C@@H1](C3)C2 CC[C@H1](C(=O)N1CCN(C(=O)C2=N[NH1]C(C3CC3)=C2C)C[C@H1]1C)N4C=CC=N4 CCOC(=O)C=CC(=O)NCCCC[C@@H1](C)NC(=O)COC1=CC=CC=C1C CC[C@@]1(C(=O)N2CCC(NC(C)=O)CC2)CCCN1C(=O)CCCCC#N CC(=O)N[C@@H1](C)C(=O)N1CC(CC(F)(F)F)C1 CC1=CC(C(=O)N2C[C@@H1]3C[C@H1]2[C@@H1]3NC(=O)[C@H1](C)NC(N)=O)=C4C(=N1)CCCC4=O CC(=O)NCC1=CC=C(C2=CSC(=NC[C@@]3(C)C[C@H1]4CC[C@H1]3C4)[NH1]2)C=C1 C=CC[C@H1](CNC(=O)CNS(=O)(=O)NC)NC(=O)CCC1=CC=NC=C1Br CC[C@H1](COC)NC(=O)C1(COC)CN(C(=O)/C=C/C2=CC3=CC=CC=C3O2)C1 CC(C)(C)C=1C=C(CS(=O)(=O)NCCN2C=NC3=CC=CC=C3C2=O)ON=1 CCN1C=NC(C(=O)N[C@H1]2CC[C@@]3(CCN(C(=O)OC(C)(C)C)C3)C2)=C1 C#CC[C@H1](NC(=O)C=CC1CCOCC1)C(=O)NC[C@@H1]2OCCCC2(C)C CN(C(=O)[C@@H1]1C[C@H1](F)CN1C(=O)CC2=CC=CN=C2O)[C@@H1]3COC[C@H1]3O COC(=O)[C@H1](NC(=O)[C@@H1]1CN(C2CCC(C)CC2)CCS1)C3=CC=NC=C3 CCCN(C(=O)C1=CC=C(N)C=C1CC)C2CCN(C(=O)C3=CC=NS3)CC2 CNC(=O)C1=CC=C(N[C@@H1]2CCN(C(=O)C3CCC4(CC3)CC4)C2)C([N+1](=O)[O-1])=C1 CC[C@H1](C(=O)N1CCC(CC)(NC(=O)C2=NN=C(O)C=C2O)CC1)C(C)(F)F CCOC(=O)C1=CC=NC(CN2C[C@H1](C#N)[C@@H1](NC(=O)NCCCl)C2)=C1 COC1=CC(NC(=O)[C@H1](C)C2CCN(C(=O)C=CC3=COC=N3)CC2)=CC=C1F CC1=NSC=C1CC(=O)N2C[C@@H1](NC(=O)[C@H1]3CCC(C)(C)OC3)[C@H1]4CCC[C@H1]4C2 CCOC1=CN=C(C(=O)N(C)CCCN2CCOCC2)C=N1 CC1=C[NH1]N=C1C(=O)NCC2(C)CC(NC(=O)C3=C(O)C=C(F)C=C3F)C2 COCCC1(NC(=O)[C@@H1]2CCN(C(=O)[C@H1](C)N3C=CN=N3)C2(C)C)CCCC1 CO[C@H1](C(=O)N[C@H1]1CCCN2CCC[C@H1]12)C3CN(C(=O)CCC4=CN(C)C=N4)C3 C#CC1=CC=C(C(=O)NCCSCC(=O)NCCOCC(N)=O)C(C)=C1 CCCC=1[NH1]C=CC=1C(=O)N2CC3(CCC3)C[C@@H1]2C(=O)N4CCO[C@H1](C)CC4 COC1CC(C(=O)NC2=CC=C3C(=C2)N(C)C(=O)CC3)C1 CCC1=NC=C2C(=N1)CC[C@H1](C(=O)N[C@@H1](C)C3CN(C(=O)C4=N[NH1]C=C4Br)C3)C2 C1=CN=CC(C=2N=C(CN3CCCOCC3)N(C4=CC=CC5=CN=CC=C45)N=2)=C1 CC(=O)C(=O)N1CC[C@H1]1C(=O)N2CCCC[C@@H1]2CO C#C[C@]1(O)C[C@@H1](C(=O)N2C[C@@H1](C)[C@H1](CCNC(=O)C=3SC=NC=3C)C2)C1 CC=CCCC(=O)NC[C@H1]1C[C@@H1](C)N(C(=O)C2=CC=C(NC(=O)C3CC3)C=C2)C1 CCN1C=C(NC(=O)C[C@@H1]2CN(C(=O)[C@@H1]3CCC[C@@H1](OC)C3)CC24CC4)C(C)=N1 CN(CCCNC(=O)C=C1CCSCC1)C(=O)[C@@H1]2CC2(C)C C[C@@H1]1C[C@H1]1CCC(=O)N(CCCNC(=O)C2CCCCC2)C3CCCCCC3 C[C@H1](C(=O)NCC[C@H1]1CC12CCOCC2)N3C=CN=N3 C[C@H1]1CN(C(=O)C2(F)CCOCC2)CC[C@@H1]1CNC(=O)C(F)(F)C(C)(C)O CO[C@H1](CO)C(=O)N(C)[C@@H1]1CCC[C@H1]2CN(C(=O)C3=CC(N)=C(F)C=C3C)C[C@H1]21 OC=1[NH1]C2=NC=NC(NCCCCNC(=O)CCSC3=CC=CC=N3)=C2C=1 C[C@@H1](C(=O)N[C@]1(C)CCCN(C(=O)CC2(O)CCCCC2)C1)C3=CC=CO3 CC[C@@H1]1CC[C@H1](C)N1C(=O)[C@@H1]2CCC[C@@H1](NC(=O)[C@H1]3O[C@H1]4CC[C@H1]3C4)C2 CS(C)(=O)=NC1=CC=CC(C(=O)NCCNC(=O)[C@H1]2C[C@H1]2Cl)=C1 C[C@@H1](CCCCCO)NC(=O)C[C@@H1](C)C(C)(C)NC(=O)C1=CC(O)=CC(C#N)=C1 COC1=NC=CC=C1C(=O)N(C)[C@H1](C)CNC(=O)C=2C=CN(C(C)C)C=2C CC(C)N1C=CC(C(=O)N2CC[C@@]3(CNC(=O)C=C4CC[C@H1](C)C4)C[C@H1]3C2)=N1 CN1CC[C@@H1](CC(=O)NC2(CNC(=O)C3=CN=C4[NH1]C(O)=NC4=C3)CCC2)C1=O CCCC[C@@H1](O)C(=O)N1CC(CC2=CN(C3=CC=C(Br)C=C3)N=N2)C1 CCCC12CC(C(=O)N(C)C[C@@H1](C)NC(=O)[C@@H1](O)CN(C)C)(C1)C2 CC1=CC(OCC(=O)N2CC[C@H1]([C@H1](F)C(=O)N(C)C[C@H1](O)C(F)(F)F)C2)=NO1 CC1=CC=CC=C1C(F)(F)C(=O)N2CCCN(C(=O)[C@H1]3CCC3(C)C)[C@@H1](CO)C2 O=C(NCCOCCCN=C1C=CC2=NC=CC=C2[NH1]1)[C@H1]3CCC[C@@H1](O)C3 COC1=CC=C(Cl)C=C1CNC(=O)C(=O)N2CCCC3=CC=CC(Br)=C32 COC(=O)[C@@H1](CNC1CCC2(C=NN(C)C2Cl)CC1=O)C3=CC=CC=C3 CC1=CC(C(=O)N(CCO)CCCNC(=O)C=2C=CC3=NSN=C3C=2)=CC=C1Cl CC[C@@H1](CNC(=O)[C@H1](CO)NC(N)=O)NC(=O)CC1=CC(F)=CC=C1Br C[C@H1](CCN=C1[NH1]N=C(C(F)(F)F)C=C1Cl)NC(=O)[C@@H1]2C[C@H1]2F CN(CCC(=O)N1CC[C@@H1](O)[C@@H1](C2CCCC2)C1)CCC(C)(C)O CC[C@H1](CC(F)(F)F)C(=O)N[C@H1]1CCN(C(=O)C2=CC=C(OCCOC)C=C2)C1 CS[C@@H1](C)C(=O)N[C@H1]1CCN(C(=O)COC2=CC=C3C(=C2F)CCC3)[C@@H1]1C(C)C NC1=CC(C(=O)N2CC[C@]3(CO)CN(C(=O)CCOCC(F)F)C[C@@H1]3C2)=CN=C1 CCOC1=N[NH1]C=C1C(=O)N2CC3(CN(C(=O)CC4=CC=CC=C4)C3)C2 CCC(C)(C)CCCC(=O)NC[C@@H1](C)NC(=O)C1=C(C)C=C(O)C=C1C CC(=CC(=O)N1CCC[C@H1](NC(=O)C2=CC=C(N)C=C2OC)CC1)C=3C=CSC=3 C[C@@]1(C(=O)N2C[C@H1]3CN(C(=O)C4=C(O)C=CC(Cl)=C4F)C[C@H1]3C2)CCCNC1=O CCC1=CC=C(C(=O)N[C@@H1]2CCOC23CCN(C4=NC(COC)=NS4)CC3)C=C1 CN(CCN=C(NCC1CCC1)NC[C@H1](Cl)C(F)(F)F)C(=O)OC(C)(C)C O=C(NC1=CC=C(Cl)C(S(=O)(=O)N2CCCCC2)=C1)C3=CC=C4C(=C3)C(=O)NC4 CC=NN(C)C=C(NC[C@H1]1CCOC2[C@@H1]1C)N=C(N(C)CCN(C)CCN(C)C)N=C2 CCC1=C[NH1]C(C(=O)NCCCN(C)C(=O)C(C)(C)C2=CC=CC=C2)=C1 CC1(C)CCCC[C@@H1]1CC(=O)NCCC2(O)CCN(C(=O)CC3CSC3)CC2 CC[C@@H1](C(=O)N(C)[C@@H1](C)C1=CN(C2=CC=CC=C2S(C)(=O)=O)N=N1)N(C)C C[C@@H1]1CC=C(C(=O)N[C@H1]2C[C@@H1](F)CN(C(=O)CCC(C)(C)C)C2)CC1 O=C(C1=CC([N+1](=O)[O-1])=C(F)C=C1Br)N2CCOC[C@H1]2C3=CC=CC=C3 N#C[C@H1]1CN(C(=O)C2=CC(F)=CC(Cl)=C2Cl)C[C@H1]1NC(=O)[C@@H1]3CCC[C@H1]3CC CC1=NOC(CCCC(=O)NC[C@@H1]2C[C@H1]2NC(=O)C=3C=C(C)N(C4CC4)C=3C)=N1 CCC[C@@H1](NC(=O)CO[C@@H1]1CCN(C(=O)CCC(=O)NC)C1)C(=O)NC CCC1=CN=C(CNC(=O)[C@]2(NC(=O)C3=CN=C(O)C(F)=C3)C[C@@H1](O)C2)O1 CC[C@H1](C(=O)N[C@H1]1CCCN(C(=O)CC2=CC(C)=CC(F)=C2)C1)C3=CC=CC=C3 C=CCN1C=CN=C1C(=O)N2CC[C@H1](NC(=O)CO[C@@H1]3CCC[C@@H1]3C)[C@H1](C)C2 CO[C@@H1](C(=O)N[C@@H1](CO)CNC(=O)C=1C=C2N(N=1)CCOC2)C(C)C O=C(NCCO)[C@H1]1COC2(CCN(C(=O)C3=CC=NC=C3Br)CC2)C1 C=CCOCCCC(=O)N[C@@H1]1CCN(C(=O)C2=CC(F)=C[NH1]2)C[C@H1]1C COC1=CC=CC(N2CC[C@H1](C(=O)NC3=CSC(C#N)=C3)C2=O)=C1 CC[C@]1(C)CC[C@@H1](C(=O)N[C@H1]2C=CCN(C(=O)C=CC3=CC=CC=C3OC)C2)O1 O=C(NC1CCN(C2=NC=C3C=CN=C3[NH1]2)CC1)[C@H1]4C[C@@]45CCOC5 C[C@@H1](CNC(=O)C1=CN=C(C2=NC=CC=N2)S1)N(C)C(=O)CCCC(=O)C3CC3 CC[C@@H1]1CCN(C(=O)[C@@H1](C)N2N=CC=C2C)[C@@H1]1C(=O)N3C[C@H1]4CC[C@@](CO)(C4)C3 C=CC1(CC(=O)N[C@]2(C)C[C@@H1](NC(=O)C3CCN([C@@H1]4CCSC4)CC3)C2)CC1 CC(C)(C)OC(=O)N[C@H1](C(=O)NCC1=C(Cl)C(C)=NN1C)C2=CC=C(Cl)C=C2 CC[C@@H1](C)[C@H1](OC)C(=O)N1CCN(C(=O)C=2C=CSC=2C)C3(CCC3)C1 CC1=CC=C(C=CC(=O)N[C@]23C[C@H1]2CN(C(=O)C4=CN(C)N=C4Br)C3)N=C1 CO[C@@H1]1C[C@H1]1C(=O)N2CCC[C@@H1](CCNC(=O)C3=CC(O)=NC(C4CC4)=N3)CC2 CSC1=CC=C(C)C(C(=O)N(C)C[C@@H1]2CCN(C(=O)C3(OC(C)C)CCC3)C2)=C1 C#C[C@]1(NC(=O)C2=C[NH1]N=C2CNC(=O)[C@]3(OCC)CCOC3)C[C@H1]4CCC[C@@H1]41 CCN(C)CC(=O)N[C@@H1]1CCC[C@]12CCN(C(=O)C3=CC4=CC=C(C)C=C4O3)C2 CC(C)C#CC(=O)N[C@H1](C)C(C)(C)C(=O)N[C@H1](CCF)C(=O)OC CC(C)[C@@H1]1CCC[C@H1]1C(=O)N[C@@H1](CO)CNC(=O)C2=CC=CC([N+1](=O)[O-1])=C2N COC1=CC=C(C(=O)N2CC[C@@H1](NC(=O)[C@]3(F)CC=CCC3)CC(C)(C)C2)N=N1 CN1CC=C(CC(=O)NC(C)(C)CCNC(=O)[C@@H1]2CC[C@H1](C3CC3)C2)CC1 CC(=O)N[C@@H1](C(=O)N1C[C@H1]2[C@H1](NC(=O)[C@H1]3CN(C)CCO3)[C@H1]2C1)C(C)C CN(C(=O)CCOC1CC1)[C@@H1]2CCCCN(C(=O)C[C@@H1]3CCCC(=O)C3)C2 CNS(=O)(=O)CC(=O)NCC1=N[NH1]C=C1C(=O)NCC2CCCCCCC2 CCO[C@@H1]1C[C@H1]1C(=O)NC[C@@H1]2CCCCN(C(=O)C3=CC(N)=CC=C3C)C2 C[C@H1](OC(C)(C)C)C(=O)N1CCC[C@H1]1C2(C(=O)NC(C)(C)CF)CC2 COCCOCCNC(=O)[C@H1]1CCCCN(C(=O)[C@@H1]2CCC[C@H1](O)C2)C1 CC(=O)N[C@]1(C2=NOC(C3=CC=C(N4C=NN=N4)C=C3)=N2)CCOC1 CN(CCC(=O)NCC1(O)CC(CO)C1)C(=O)[C@]23C[C@H1]2CCC3(F)F CCC1=CC=CC=C1C(=O)N2CCCCC[C@@H1](NC(=O)C=3N=COC=3C4CC4)C2 O=C1C[C@H1]2C(C(=O)N3CC[C@H1](C(=O)N4CCN5N=CC=C5C4)C36CCC6)[C@@H1]2C1 CC1=NN(C)C=C1[C@@H1](C)NC(=O)CC2CC3(C2)CN(C(=O)[C@@H1]4C[C@H1]4C#N)C3 CC=1SC(C(=O)N2CCC(CNC(=O)C(Cl)(Cl)Cl)CC2)=CC=1CS(C)(=O)=O CC1=CC(C(=O)N(C)[C@@H1](C)CCNC(=O)C2=CN=CC(C(F)(F)F)=C2)=CO1 COC(=O)[C@H1]1CCN(C(=O)C[C@@H1]2[C@@H1](NC(=O)[C@H1](C)OCCN(C)C)C[C@H1]2O)[C@@H1]1C COCC=1N=C(C[C@@H1]2COC(C)(C)C2)N(C3=CC=C(OC(F)(F)F)C=C3)N=1 C#CC1=CC=C(CC(=O)N[C@@H1](C)/C=C/C(=O)N[C@H1]2CC(C)(C)OC2=O)C=C1 CCC1=NC(CCNC(=O)[C@@H1]2COCC[C@H1]2NC(=O)C34CCC(CC3)C4)=NO1 CCN1C=C(C(=O)N[C@]23CCOC[C@@H1]2CN(C(=O)C4=CC(C)=C(C)[NH1]4)C3)C(C)=N1 CC1=NC(CN2CC3=C([NH1][NH1]C3=NC(=O)[C@@H1](C)NC=O)C2=O)=CO1 CCC1=NOC(CCC(=O)N[C@@H1]2CC[C@](F)(CNC(=O)[C@@H1]3CCCC[C@H1]3O)C2)=N1 C[C@@H1](C(=O)N1CC(O)(CN(C)C(=O)C(C)(C)N2C=C(Cl)C=N2)C1)S(C)(=O)=O C[C@H1](CC(N)=O)C(=O)N[C@H1]1[C@@H1]2CC[C@@H1](C2)[C@H1]1C(=O)NC3(CCO)CCCC3 CC(C)OC[C@H1](NC(=O)CN1N=CN=N1)C(=O)N[C@H1]2COC3=CC=CC=C32 C#CCC=NNCC(=O)N1CCCC[C@@H1](CCC(=O)N2CC=C(C)C2)C1 O=C1C[C@@H1](C(=O)NCCC2(O)CN(C(=O)[C@@H1]3CCO[C@H1]3C(F)(F)F)C2)CO1 CC1=C[NH1]N=C1C(=O)N2CC[C@@](O)(CCNC(=O)CC3=CSC=N3)C2 CC(C)(C)[C@](C)(O)CNC(=O)CCN(CCO)C(=O)[C@H1](O)C1CCCCC1 COC1(CNC(=O)C2=CC=CO2)CN(C(=O)C(F)(F)[C@H1](O)C(C)C)C1 C[C@]1(NC(=O)C2=CN=CC(Cl)=C2)CCCN(C(=O)C=3C=NN([C@@H1]4CC4(F)F)C=3)C1 CSC[C@H1]1CCN(C2=NC=CC(=NCCC3=NC=CC4=C3CCCC4)[NH1]2)C1 CC1(C(=O)NC[C@@](C)(CO)NC(=O)C2=C[NH1]C(C(F)(F)F)=C2)CS(=O)(=O)C1 C[C@@H1]1CC[C@@](C)(C(=O)NC2CC(CNC(=O)CC3=CSC(Cl)=N3)C2)C1 CC1=CC=NC(S(=O)(=O)N2CCN(C(=O)NCCCN(C)C)CC2)=C1 C[C@@H1](C(=O)N(C)[C@@H1]1CCCC[C@H1]1N(C)C(=O)C=CCF)C2=CC=C(F)C=C2F CC1CN([C@H1](C)C(=O)N2[C@H1](CNC(=O)C=3C=C(O)N(C)N=3)C[C@@H1]4C[C@@H1]42)C1 CN(C(=O)C=CC1=CC=C[NH1]1)C2(C(=O)N[C@@H1]3CCCCC[C@@H1]3F)CC2 CC1=NC(SCC(=O)NCC2CC(NC(=O)C3=CC=NC=4[NH1]C(O)=NC3=4)C2)=N[NH1]1 O=C(CC1=CCCC1)NC2(C(=O)NCCN3CC[C@H1](CO)C3)CCCCC2 COC(=O)C1=CC(C(=O)NCC2CC3(C2)CC(NC(=O)[C@H1]4CC(C)=NO4)C3)=NO1 CC1(C)[C@H1](C(=O)N2C[C@H1](CNC(=O)C3=CN4C(=N3)CCC4)CC25CCC5)C1(F)F O=C([C@H1]1CCN1C(=O)NOCCF)N2CC3CC2C3 CC(C)(O)C1(CNC(=O)C=2C=CON=2)CN(C(=O)[C@@H1]3CCC4=N[NH1]C=C4C3)C1 COCC1(NC(=O)[C@H1](C)CC2CCC2)CN(C(=O)C3=COC4=CC=C(F)C=C34)C1 CC[C@H1](CC1=CN([C@@H1]2CCN(C(=O)C3=CC=CN=C3OC)C2)N=N1)C(=O)OC CCC[C@H1](C)CC(=O)N[C@H1]1CCN(C(=O)CCCC#CC2=CC=CC=C2)[C@@H1]1C C[C@H1](NC(=O)C/C=C/CNC(=O)C=1C=C[NH1]C=1)C23CC(CO2)C3 C=C1CC(C(=O)N[C@@H1]2C[C@@H1]3CN(C(=O)[C@@H1]4[C@H1]([N+1](=O)[O-1])[C@H1]4C(F)(F)F)C[C@H1]3C2)C1 C=C(Cl)C[C@@H1](NC(=O)C[C@H1]1COCC1(C)C)C(=O)N2O[C@H1]3CC[C@H1]2C3 CCCC[C@@H1](CNC(=O)C(C)(C)CC1=CC=CC=C1)NC(=O)C2CC3(CC3)C2 CC(=O)OC(C)(C)C(=O)N[C@@H1]1C[C@@H1]1NC(=O)CCSC2=NC=NC=3[NH1]C=NC2=3 CC[C@H1](CNC(=O)CC1=CC=C(F)C=C1F)NC(=O)CC=2SC=CC=2Br C[C@H1](CNC(=O)C1=CC=C(Br)C=C1C#N)CNC(=O)[C@H1]2C[C@@](F)(CO)C2 C[C@@H1]1CCC[C@H1](C2=NO[C@@H1](C(=O)NCC3=CC=CC=4C=NN(C)C3=4)C2)C1 CC=1N=C(N[C@@H1]2C[C@@H1](NC(=O)C34CCC(C)(CC3)CO4)C25CCC5)[NH1]C(=N)N=1 CC(C)C[C@@H1](O)CC(=O)N1CCN(C(=O)C2=NC(Cl)=CS2)[C@H1]3COC[C@H1]31 CC1=CC(C(=O)N2CCCCCC[C@@H1]2C(=O)N3CC(C=4C=CON=4)C3)=NC(C)=N1 CC=1C=NN(C)C=1CC(=O)NCCNC(=O)C=2C=C(C=3C=CN(C)N=3)ON=2 CC1=C(C(=O)NC[C@@H1]2[C@H1]3CC[C@H1](C3)N2C(=O)[C@H1]4CC4(C)C)C=NN1C(C)C C=C(C)C[C@@H1](C)C(=O)N1CC[C@@H1]1CNC(=O)CN2C(=O)CCC2=O CC1=CC(C(=O)N2CC[C@H1]3CCC[C@@H1](C2)N3C(=O)C4=C(C)N=C(C)N4O)=NC=N1 CCCC[C@@H1](CNC(=O)C1=CC=C(Cl)C=C1)NC(=O)C23[C@H1]4CC(C[C@H1]42)C3(F)F CN(C)[C@@H1](CCO)C(=O)N1CCN(C(=O)C=C(C2CC2)C3CC3)C[C@H1]1CO CCC[C@@H1](O)C(=O)N[C@@H1](C)CC1CN(C(=O)CCC2=NC(CSC)=NO2)C1 CCC1=C(Cl)N=C[NH1]C1=NCCCOC2CCN(C(=O)COC=3C=CON=3)CC2 C[C@H1](NC(=O)C1CCC1)C(=O)N[C@@H1](C(=O)O)C2CCN(C)CC2 C[C@H1]1CC[C@H1](NC(=O)C2=N[NH1]C=C2Cl)CN1C(=O)C34CC5C[C@H1]3[C@H1]4C5 CC1=CC=CC=C1CC(=O)N[C@]2(CNC(=O)C3=NC=CN3C)CCOC2 CO[C@@H1]1CC[C@@H1](C)N(C2=CC(N3CCS(=O)CC3)=NC=N2)C1 CCC1=NC=CC=C1C(=O)NCCC2=NC=CC=C2F O=C(NC1CCC2(CC1)C[C@@H1]2NC(=O)C3CC4(CC4)C3)C=5OC=NC=5C(F)(F)F CCC=1N=N[NH1]C=1C(=O)N2CC[C@H1](C(=O)NC3(CC4CC4)CC3)C2 NC1=NC=C(Br)C=C1S(=O)(=O)NCC2=CC=NN2C(F)F C#C[C@H1](NC(=O)[C@H1](NC(=O)CN1CSCC1=O)C2=CC=CO2)[C@H1](C)OC O=C(NCC=1C=COC=1C(=O)NCCC2CCC2)[C@@H1](O)C3CCCC3 CC1=CC(C(=O)N2CCN(C(=O)C3=CC=C(F)S3)[C@@H1](C)[C@H1]2C)=CN=C1O CC(C)[C@@H1](F)C(=O)N1CC(O)(C(C)(C)CNC(=O)[C@@H1]2C[C@H1]3C=C[C@@H1]2C34CC4)C1 CCC1=CN=C(C(=O)NC[C@@](C)(CO)NC(=O)[C@@H1]2CS(=O)(=O)CC(=O)N2)C=N1 COCCN(CCOC)C(=O)[C@@](C)(C1CC1)N(C)C(=O)CCOC2COC2 CC[C@]1(C)CC[C@H1](C(=O)NC[C@@H1]2C3=CC=CC=C3CCN2C4=NC(SC)=NS4)O1 CC1=CC=C(C2=CC=C3C=C(C(=O)NC[C@H1](O)C4=CC=C(O)C=C4)N(C)C3=C2)S1 CCC1=CN=CC(C(=O)N[C@H1]2CCN(C(=O)C3(C(C)(F)F)CC3)CC2(C)C)=C1 CCOC1=CC=C(C(=O)N(C)[C@@H1](C)CCNC(=O)C2=CC(C)=NN=C2O)C=C1 CN(CC1=CN(CC=2ON=CC=2C(=O)O)N=N1)C(=O)CCOC[C@H1]3CCCO3 COC[C@@H1](O)C(=O)N[C@H1]1CCN(C(=O)C2(C3=CC=CC(Br)=C3)CCCC2)C1 COC1=CC(O)=CC=C1NC(=O)C2=C[C@@H1](O)[C@@H1](O)[C@H1](O)C2 C=C=CC(C)C(=O)N1CCC(O)(CN(C)C(=O)[C@@H1]2OC[C@@H1]3CCC[C@@H1]32)CC1 CS(=O)(=O)NCCCC(=O)NC[C@@H1]1COCCN(C(=O)C2(CO)COC2)C1 CC1=CN(C)C=C1C(=O)NCCC2CCN(C(=O)C3=CSC=C3C4CC4)CC2 COC[C@]1(C(=O)N2CC(N(C)C(=O)C3=CN=C4C=CSC4=C3)C2)C=CCC1 C[C@H1]1CC[C@H1](C)N1CC(=O)N[C@H1]2C[C@H1](F)CN(C(=O)C3(N(C)C)CCOCC3)C2 C=C(I)CC(=O)N1C[C@H1](F)[C@H1](N(C)C(=O)COC2CC2)C1 CC(C)C1=NC(C(=O)N2C[C@H1](O)[C@H1](NC(=O)[C@H1]3C[C@H1](N4C=CN=N4)C3)C2)=CO1 CC1=CC=C(C=CC(=O)N2CC[C@@H1](C)N(C(=O)C3=CN=C4N3CCC4)CC2)C=C1 CC1=CN=C(CC(=O)NCC2(NC(=O)[C@H1]3CCCO[C@@H1]3C)CCCC2)O1 CN(CCN(C)C(=O)[C@@H1]1COCC2(CCC2)O1)C(=O)COC3=CC=C(Cl)C(Cl)=C3 CC1=CC=C(Br)C(C(C2=NC(C3=CC4=CC=CC=C4O3)=NN2C)CC)=C1 CCCCC(F)(F)C(=O)NC[C@H1]1C[C@]2(CCN(C(=O)C3=NN(C)C=C3N)C2)CO1 CCC1=NN(C)C=C1CNC2=NC=CC(=NCC(=O)N3CCCC4=CC=CC=C43)[NH1]2 CC1=C(C(=O)N2CC(O)(CCNC(=O)C[C@H1]3CCCO3)C2)C=NN1C(C)C COCCNS(=O)(=O)C1=CC=C(Cl)C(C(=O)N(C)[C@@H1]2CC[C@H1]3C[C@H1]32)=C1 CC=CC=CCCCC(=O)N1C[C@H1]2C[C@@H1](NC(=O)C3=CN=C(C)N=C3)C[C@H1]1C2 C=C(C)CC(=O)N1CCC[C@H1](N(C)C(=O)C2=CC(OC)=CC3=CC=CC=C23)C1 CCC=1[NH1]N=C(C(=O)NCCCCC2(NC(=O)[C@H1]3CCCC[C@H1]3OC)CC2)C=1Cl CC1=NOC(C(F)(F)Cl)=C1C(=O)NC[C@H1]2CCCCN2C(=O)C3(F)CCCCC3 CC(C)C=1ON=CC=1C(=O)N2CCC3(C2)CN(C(=O)[C@H1](C)SC[C@H1]4CCCO4)C3 CC1=NC=NC(C)=C1C(=O)N[C@@H1]2CCCC[C@@H1]2CNC(=O)[C@@H1]3CCOCC3(C)C CC1=NC(CC(=O)N2CC[C@H1](C)[C@H1](NC(=O)CC3=CC=CC(C(N)=O)=C3)C2)=N[NH1]1 C[C@H1](C#N)CCC(=O)NC[C@H1]1CCCN1C(=O)CC2=CN=CN2C3CC3 COC1=NC=C(Cl)C(C)=C1C(=O)N[C@@H1]2CC[C@H1]3CCN(C(=O)C(C)=C4CCC4)[C@H1]3C2 O=C(C=CCF)N[C@@H1]1CCN(C(=O)CC2(O)CCCCC2)CCC1(F)F CCC1=CC=CC=C1[C@@H1]2C[C@H1]2C(=O)N(CCO)CCCNC(=O)C3(CO)COC3 CCC1=CC(C(=O)NC2(C(=O)N[C@H1]3CCC[C@@H1]3C)CC(CO)C2)=NS1 O=C(NC[C@H1]1CCCN(C(=O)C2=CN=C3C=CSC3=C2)C1)[C@H1]4CC=CCO4 O=C(N1CCN(C(=O)CCF)CC1)C2=CC=CC(OCC3CC3)=C2 CC1=CC=C(NC(=O)[C@@H1]2CCCN(C(=O)C3=CC=C(Cl)C=N3)CC2)C(Br)=N1 N#CCN1C=C(NC(=O)NC[C@@H1]2C[C@H1](O)CCO2)C=CC1=O CC1=CC=CC(C(=O)N(C)CC(CO)(CO)NC(=O)CN2N=CC=N2)=C1C#N COCCOCCN(C)CCC(=O)N[C@H1](C)C1(O)CN(C(=O)[C@H1]2CCCS2)C1 C#CC1=CC=CC(C(=O)NCC2=NC(CNC(=O)CCCC#CC)=CS2)=C1C CO[C@@H1](CSC)C(=O)N[C@@H1]1CCC12CN(C(=O)C3=CC(C)=C4[NH1]N=NC4=C3)C2 CC1=NOC=C1C(=O)N2CC=C[C@H1](NC(=O)C3=CC=CC(N4CCNC4=O)=C3)C2 C#C[C@]1(O)C[C@@H1](C(=O)N2CC[C@H1]([C@H1](C)C(=O)N3CCN(C4CCC4)CC3)C2)C1 CC1(C)CCN(CC(=O)NC[C@@H1]2CCC3(CC3)C2)CC1 COCC(C)(C)C(=O)N1C[C@@H1](CNC(=O)CS(=O)(=O)C(C)C)C(C)(C)C1 CN1C=NC(C(=O)COC(=O)C2=CC=CC([C@H1]3CC3(F)F)=C2)=C1 CC(C)/C=C/C(=O)N1CCN(C(=O)[C@H1]2C[C@H1]3COC[C@H1](C3)C2)[C@@H1](C)[C@@H1]1C COC1=NC=C(CO)C=C1NC(=O)[C@@H1]2CSCCN2CC3=C(F)C=C(F)C=C3Br CN1N=NC=C1CC(=O)NC2CC(C)(NC(=O)C3=CC(O)=C4C=CSC4=C3)C2 CN(C(=O)C=1C=CN(CCF)N=1)[C@H1](CNC(=O)C(C)(C)C)C2=CC=CC=C2 O=C(C[C@H1]1CCCN1C(=O)C=C2CCC2)N[C@@H1]3COCC[C@H1]3O O=C(NC1(C2CC2)CC1)C3=CC=C(CNC(=O)[C@@H1](O)C=4C=CSC=4)O3 C[S@@](=O)C1=C(Cl)C=CC=C1NC(=O)C2=CC(F)=C(Br)C(F)=C2 CC=1C=CN(C[C@H1](C)C(=O)N[C@H1]2CCCC[C@H1]2CNC(=O)CC(F)(F)F)N=1 C[C@@H1](CC(=O)N1CCCC[C@H1](NC(=O)[C@H1](C)C2=CC=C(Cl)C=C2)C1)N3C=CN=C3 C[C@@H1](CCC(=O)N1CC[C@](O)(CN(C)C(=O)COC2CCC2)C1)C3=CC=CC=C3 CC=1OC([N+1](=O)[O-1])=CC=1C(=O)NC[C@H1](C)NC(=O)[C@@H1]2C[C@]2(C)C(F)F CC=1SC=CC=1C(=O)N[C@H1](C)C(C)(C)NC(=O)C2=NC3=CC=CN=C3S2 COC1=CC=C(F)C=C1[C@@H1](NCC=2SC(Br)=NC=2C)C3=NN=NN3C4CCCC4 CC(C)N(CCN(C)C(=O)CN1C=NC(=N)[NH1]1)C(=O)C2=CC=NC(F)=C2Cl CCNS(=O)(=O)C1=CC=CC(C2=CC=NC(O)=C2CN(C)[C@@H1](CO)OC)=C1 C[C@@H1](NS(C)(=O)=O)C(=O)N1CC2(NC(=O)C=3C=N[NH1]C=3)CC1C2 C=C(C)CCCC(=O)N1C[C@H1]2CC[C@@]2(CCNC(=O)C3=CC=NC=C3F)C1 CC(C)/C=C/C(=O)N1CC[C@@H1]2C[C@]2(C(=O)NCC3=CC=NC=C3Cl)CC1 CCC(CC)CCC(=O)N1CCC[C@@H1](C(=O)N[C@@H1]2C[C@H1](O)[C@H1](O)CC2)CC1 CCCC[C@@H1](C(=O)NC1(CCCNC(=O)C[S@@](=O)CC)CC1)N(C)C C=CCC(C)(C)C(=O)NC[C@@]1(O)CCCN(C(=O)C2=CN=C(O)N2C)C1 CO[C@@H1]1CCC[C@@H1](C(=O)N[C@H1](C)C[C@H1](C)NC(=O)C2=CC=C(S(C)(=O)=O)S2)C1 CSCCCN[C@H1](C1=NN=NN1C)C2=NC3=C(S2)CC(C)(C)CC3 CCOC(OCC)C(=O)NCC(=O)NOC[C@H1](O)CO CC=1C=CN(CC(=O)N2CC[C@@H1](C)[C@@H1](NC(=O)CCCC3=CC=CS3)C2)C(=O)C=1 O=C(C1=CC=C(F)C(O)=C1)N2CC3(C2)CN(C(=O)[C@@H1]4CCC[C@@H1]5CCCC[C@H1]54)C3 CCS(=O)(=O)C1=CN=C(O)C(C(=O)N(C)[C@H1](C)CNC(=O)CC[C@@H1](C)OC)=C1 C=CC[C@H1](CC(C)C)C(=O)N1CC[C@@H1](CN2C=C(CCC(=O)CCO)N=N2)C1 CS[C@H1](C)CCC(=O)NC1C[C@H1]2CN(C(=O)C(C)(C)COCC(F)F)C[C@@H1]2C1 CC1=CN=CC(C(=O)NC[C@@H1]2CN(C(=O)[C@@H1]3CC4=CC=CC=C43)CCC2(F)F)=N1 CC1=NC(=N)[NH1]C(C)=C1C(=O)NCCCN(C)C(=O)C2=CSC(S(N)(=O)=O)=C2 O=C(O)C1=CC=NC(S(=O)(=O)NC[C@]2(F)C[C@@H1](CO)C2)=C1 CC=1C=CC(=O)N(CC(=O)NC[C@@H1]2CN(C(=O)[C@@H1](C)OC3CCCC3)C[C@H1]2C)C=1 C=C=CCCC(=O)N1[C@H1]2CC[C@@H1]1CN(C(=O)C3(OC)CCCCCC3)C2 CC[C@H1](C)CCC(=O)N1CCC[C@H1]1[C@H1](C)NC(=O)C2=CN(CCO)N=N2 CC1=CC=NC(NC2=CC=CC(C(=O)NC3=C(Br)C=CC4=C3CNCC4)=C2)=N1 CN(C)C[C@@H1]1C[C@@H1]1C(=O)N2CCCC[C@@H1](N(C)C(=O)CN3C=NC([N+1](=O)[O-1])=C3)C2 O=C(C1=CN=C2N1CCCC2)N3C[C@H1](NC4=CC(CC5CC5)=NC=N4)C6(CC6)C3 O=C(N[C@@]1(CO)CCCN(C(=O)C2=CC(Br)=N[NH1]2)C1)C3=CC=C(C4CC4)O3 C[C@H1]1CCC[C@@H1](C(=O)NCCO[C@H1]2CCN(C(=O)[C@@H1](C)C=3C=NN(C)C=3)C2)CC1 CC1=CC(=NC(=O)[C@@H1](CC2CC2)NC(=O)C=3C=CN(C(C)C)N=3)[NH1]N1C(C)C O=C(CC1=CC=C(Cl)C=C1)N[C@@]2(CF)CCN(C(=O)[C@@H1]3CC(=O)C34CCCC4)C2 COC(=O)[C@H1]1CN(C(=O)C(=O)NC[C@@]2(C)CCCC2(F)F)C[C@@H1]1C3=CC=CC=C3 CCOC(=O)[C@H1](CCOC)NC(=O)C1=CC=C2C(=N)[NH1]C=NC2=C1 O=C(C=CC1=CNC=C1)NCC2(C(=O)N[C@H1]3[C@H1](O)[C@H1]4CCO[C@@H1]34)CC5(CC5)C2 CC(C)N1C=CC(C(=O)NC[C@@](C)(CO)NC(=O)C2=CC=C3C=C[NH1]C3=C2)=N1 CC1=CC(F)=CC=C1C(=O)NC[C@@H1]2CCC[C@@H1]2C(=O)N(C)CCC[C@@H1](C)O CC(C)N1C=C(C2=CC=C3[NH1]C=C(CC(=O)N4[C@H1]5CC[C@@H1]4CNC5)C3=C2)C=N1 C=CCNC(=O)[C@@H1]([C@H1]1CC1(C)C)N(CCC(C)C)CC2=CC=C(Cl)C=C2 CC[C@H1](C)[C@H1](C)C(=O)N[C@H1](CC)CNC(=O)C1=CC(O)=C(OC)C(C#N)=C1 CC=1N=C[NH1]C=1CNC(=O)C(C)(C)[C@@H1](C)NC(=O)[C@@H1](C)CN2C=CC=N2 CNC(=O)NCC(=O)N(C)C[C@H1]1CC[C@H1](NC(=O)C[C@@H1](C)C2=CC=CN=C2)CC1 CC1=NN=C(C(=O)N2CCC[C@]2(C)CNC(=O)C=3C=C4C=CC=CN4C=3)S1 C=C1C(C2([C@@H1](NCC3=NC=C(Br)S3)C4=NN=NN4C5=CC=C(F)C=C5)CCC2)=CS1 CCN(CC(C)(C)CNC(=O)[C@@H1]1CC(=O)N(OC)C1)C(=O)[C@H1](C)CCCOC CCC1=CSC=C1C(=O)N2CC[C@@](F)(CNC(=O)C3=NC=C(OC)N=C3OC)C2 [N-1]=[N+1]=NCC(=O)N1CCC([C@H1](O)CNC(=O)COCC2CC2)CC1 O=C(N[C@]12C[C@H1]1CN(C(=O)CC3CC3)C2)[C@@H1]4CN(CC5=CC=CC=C5)CC4(F)F O=C(N[C@@H1]1C[C@@H1]2C[C@H1]1CO2)N(CCC3=CC=C(Cl)C(Cl)=C3)C4CCCC4 C#CCCONC(=O)C1(F)CN(C(=O)CN2CCNC(=O)C2)C1 C=CCC1(CC(=O)N[C@H1](C)[C@H1]2CCCN(C(=O)C=CC3=NC=C[NH1]3)C2)CCCC1 CCN(CCNC(=O)C1=CC(Cl)=C2C=CN=CC2=N1)C(=O)[C@H1]3CCCN3N=O O=C(CC1CC1)N[C@@H1]2CN(C(=O)C34COCC(C3)C4)CC[C@@H1]2C5=CC=CC(F)=C5 CC(C)=C(C)C(=O)N1C[C@H1](NC(=O)CC2=CC=NS2)CC1(C)C CO[C@H1]1C[C@H1](NC(=O)[C@@H1]2C[C@H1]2OC)CN(C(=O)C3=CC=CC(Br)=C3N)C1 CC1(C)CC[C@@H1](CC(=O)N2C[C@H1]3CC[C@@](C(=O)NC[C@]4(C)CC4(F)F)(C3)C2)C1 CC(C)S[C@H1](C)C(=O)NCCNC(=O)C1=CN=C(O)C2=NC=CC=C12 CO[C@H1](C)CCC(=O)N1CCC(O)(CN(C)C(=O)C2=C(F)C=C(N)C=C2F)CC1 O=C(CCCCCNC(=O)CN1C(=O)CNC1=O)NCCN2C=NC=N2 COC(=O)C1=CN=CN1CC(=O)N2CCC(CCCCNC(=O)C3=CC=C[NH1]3)C2 CC1=C(Br)C=NC=C1C(=O)NC2(C)CN(C(=O)C[C@H1](C)P(C)(C)=O)C2 CC=1N=C(CO)SC=1C(=O)NC[C@@H1]2C[C@@H1]3C[C@@H1]3N2C(=O)CC4=CC=CS4 O=C(N[C@]1(CNC(=O)C2(CO)CCOCC2)CCOC1)C3CCCC3 CC[C@@H1](CCC(=O)N(C)C[Si](C)(C)C)NC(=O)[C@@H1](C)OCC(C)C CC[C@H1](C)NC(=O)[C@@H1](C1=CC(C(C)(C)C)=NN1C)N(C)[C@@H1]2CCN(C3CC3)C2 O=C(N[C@]12CCC[C@@]1(F)CN(C(=O)CC3CC(F)C3)C2)C4=CC=C(O)C=N4 CN(C(=O)C=1C=CC2=C[NH1]N=C2N=1)[C@H1]3CC[C@@H1](NC(=O)C=CC(N)=O)CC3 CC[C@]1(C(=O)N2CC[C@](O)(CCNC(=O)/C=C/C(C)(C)SC)C2)CC[C@@H1](O)CC1 C=C[C@@H1](CC)C(=O)N[C@H1](C(=O)N[C@H1](CCCC)C(C)(C)C)C1=CC=CN=C1 CCC1=CC=NC(CNC(=NC[C@H1]2CCCO2)N(C)CC3COC(C)(C)OC3)=C1 C[C@H1]1CN(C(=O)C23CC(F)(CO2)C3)C[C@H1](CCNC(=O)[C@@H1]4C[C@@H1]5CC[C@@H1]5C4)O1 CC[C@@]1(C(=O)NCCOCC(C)(C)C)CCCN(C(=O)COC(C)(C)C)C1 COC1=N[NH1]C(C(=O)N[C@@H1]2CCC[C@H1](CNC(=O)[C@H1](C)C3=CC=CN=C3)C2)=C1Cl C=C[C@H1]1CCN1C(=O)[C@@H1]2CCN(C(=O)[C@@H1](CSC)OC)O2 COC(=O)C1=CC=NC(C(=O)NCCC2(N)CCN(C(=O)C3=CSN=N3)CC2)=C1 CN1CC2(CCN2C(=O)CC3CCC(NC(=O)C4=NN=C(O)N=C4O)CC3)C1 C[C@H1]1CN(C(=O)[C@H1]2C[C@@H1](O)CN2CC3=CC=CC(N4C=CC=N4)=C3)CCO1 CN(CC1=CC=NC=C1Br)[C@@H1]2CN(C(=O)OC(C)(C)C)CC2(C)C CC(=O)N1CSC[C@@H1]1C(=O)NCCCNC(=O)C2CC3(CCC3)C2 COC[C@H1]1CN(C(=O)CCC=2C=N[NH1]C=2)CCN1C(=O)[C@H1](F)C3(O)CCCC3 C[C@@H1]1CCO[C@@H1]1CC(=O)N2CC([C@H1]3CN(C(=O)CCC(C)(C)[N+1](=O)[O-1])CCO3)C2 CC=1C=C[NH1]C=1C(=O)N[C@H1]2CC[C@@H1](CNC(=O)C3=CN=C(C4=CC=CO4)S3)C2 CC(C)(C)OC(=O)N1[C@@H1](C(=O)NC2=NC=CC3=NC=NC=C23)C[C@H1]4C[C@@H1]41 CN1C=CC(C(=O)N2C[C@@H1]3C[C@H1](C2)CN3C(=O)C4=CC=C[N+1]([O-1])=C4)=C1C5CCC5 CC[C@H1](C(=O)N1CC(N=C2[NH1]C3=NC=NC3=C(C(F)(F)F)[NH1]2)C1)[C@H1](C)O COC[C@@H1]1COCCN1C(=O)COCCNC(=O)[C@@]2(O)CCOC2(C)C CC[C@@]1(C)CCCN(C(=O)[C@@H1]2C=CCN(C(=O)C=3C(CO)=N[NH1]C=3C)C2)C1 C[C@H1](C1=CC=CC(S(C)(=O)=O)=C1)N(C)C(=O)C[C@H1]2C[C@@H1](NC(=O)OC(C)(C)C)C2 C=CCCC(=O)N[C@H1]1C[C@@H1]1C(=O)NC2=C(O)C=CC=C2C#N C[C@@H1]1CCN(C(=O)C=2C=CC3=NC=CN3C=2)C[C@H1]1NC(=O)C(F)(F)C(F)(F)F CN1C=C([C@@H1](NC(=O)C[C@H1]2CCCOC2)C(=O)NCCN3C=CC(=O)C=C3)N=N1 O=C(N[C@H1]1CCSC1)[C@H1]2CCCN(C(=O)CCCN3C=CC=N3)CC2 O=C(NC1=NC=C(F)C=N1)[C@@H1]2CN(C(=O)C3=C(I)C=CN=C3Cl)CC[C@@H1]2O O=C(NCC1=NC2=CC=CC=C2N1C3CC3)N4CC[C@@H1](C(F)F)C4 CCOCCN(C)C(=O)[C@@H1]1[NH1]C2=CC=CC=C2C(=O)N1C3=NC=CC=C3F C#CC[C@@]1(C(=O)N[C@@H1]2CC[C@H1](CCC(=O)N(C)C[C@@H1](O)CO)C2)CCOC1 COC1=CC=C2OC(C(=O)NCC3CN(C(=O)C[S@@](=O)C(F)(F)F)C3)=C(C)C2=C1 C=C=C[C@@H1](C)C(=O)NC1(CC(=O)NCCC2=CC=CS2)CCC1 CCC1=NOC=C1C(=O)N[C@H1]2CC[C@@H1](NC(=O)C[C@H1]3OCC[C@@H1]3C)CC2 CC1=CC=C(F)C=C1C(=O)NCC2(O)CC(CNC(=O)COCCN(C)C)C2 COC1=C(Br)C=C(C)C=C1NC(=O)N=C2C=CN(CCOCCO)[NH1]2 C[C@]1(CNC(=O)CCCCO)CCCN1C(=O)C=2C=CC3=N[NH1]C=C3C=2 O=C(N[C@H1]1CCCC[C@H1]1NC(=O)C(F)(F)C2(O)CCCCC2)C3=CN=CC(O)=C3 CC(C)[C@H1](OC1=CC=CC=C1C#N)C(=O)N(C)CC23CCC(CC2)C3 COC[C@@](C)(OC)C(=O)N[C@@H1](CNC(=O)C1=NC(Cl)=C(Cl)S1)C2CCCC2 C=CC[C@H1](CC)C(=O)NCC(C)(C)CC1CN(C(=O)[C@@H1]2CCN(C)C(=O)C2)C1 CC=1N=C(C)N(CC(=O)NC[C@@H1](CO)CNC(=O)C2=CC=CN=C2N(C)C)N=1 CCCCN1N=NN=C1[C@@H1](NC2CN(C3=CC=C(C)C=N3)C2)C=4SN=NC=4CC CC=1[NH1][NH1]C2=NC=NC(=NC[C@H1]3CN(C(=O)CC(F)(F)C(F)(F)F)C[C@@H1]3C)C=12 CCCOC1=CC=CC=C1C(=O)N2CC(N3C=C(C4=CC=CC(F)=C4C)N=N3)C2 CCOC[C@H1](C(=O)NCCN1C=NN=C1C2CC2)N3C=C(COC(C)(C)C)N=N3 C=C=CCC(=O)N1CCC[C@@H1]2CN(C(=O)C[C@@H1]3CC[C@@H1](C)CO3)CC[C@@H1]21 CCC1=CC(C(=O)N2[C@H1]3CC[C@@H1]2C[C@@H1](CNC(=O)C#CC(C)(C)C)C3)=NO1 CN1CC(CC(=O)N2CC[C@H1]3[C@@H1](C2)CN3C(=O)C4CCC(S(C)(=O)=O)CC4)C1 C[C@@H1]1[C@@H1](C)C1(Br)C(=O)N2CC(C)(C3=CC=CC=C3C(F)(F)F)C2 CC#CCCCC(=O)N1CC=CC[C@@H1]1C(=O)NC[C@H1]2CCO[C@@H1]2CC COCC1(NS(=O)(=O)C2=CC=CN=C2N(C)CC3=NC(C(C)C)=NO3)CC1 C=C(F)CNC(=O)[C@H1]1C=CCN(C(=O)C=2C=NSC=2C)C1 CC=C1C=C2C(=NC[C@@H1]3CC4CCC3CC4)[NH1]C(=NCCC=5SC=NC=5C)[NH1]C2=C1 CC(C)(C)OC(=O)N1CCC[C@@](O)(CCNC(=O)/C=C/CN2CCOCC2)C1 CC(C)(C)NC(=O)C1=CC=C(S12)C(CCNC(=O)C3=CC(O)=NC(O)=N3)CC2 CCO[C@@H1](C(=O)N1CC2(CCOCC2)C[C@@H1]1CNC(=O)C3=CC=C(F)S3)C4CC4 CC1=C[NH1]N=C1C(=O)N2C[C@H1](CNC(=O)[C@H1](C)C3=CC=C(Cl)C=C3)C(C)(C)C2 CCC1(NC(=O)C2=CSC3=CC=CC=C23)CCN(C(=O)COC4CCCC4)CC1 C=CCCC[C@@H1](NC(=O)CCOCCC)C(=O)NCC1(O)CCC1 COC1(C(F)(F)C(=O)NC[C@H1]2CCC[C@@H1]2NC(=O)C=CCN3C=NC=N3)CCC1 O=C(NC1CC2(CCCN(C3=CC(O)=NC=N3)C2)C1)[C@H1]4C[C@@H1]4F C=CC1(C(=O)NC2CN(C(=O)CC[C@@H1]3CC[C@@H1](C)O3)C2)CCC1 C[C@@H1](CN(C)C(=O)C1=C[NH1]C2=CC=NC=C2C1=O)NC(=O)[C@H1]3CC(=O)N(C)C3 CCN(C(=O)C1=CSC(S(N)(=O)=O)=C1)C2=CC=CC(Br)=C2 N#C[C@@H1]1CN(CC2=CN=C(C3CCC3)S2)CCCO1 C[C@H1]1CN(C(=O)C2=CN(C)C3=CC=C(Cl)C=C23)C[C@H1](C)C1NC4=NC=NC=C4Br CSC1=NC=C([C@@H1](NC[C@@]2(C)CCOC2)C3=NN=NN3CCCF)S1 N#CC1=CC=NC(N2CCC([C@@H1]3CCCN(C(=O)C4CC=CC4)C3)CC2)=N1 CCC1=NC(C)=NC=C1C(=O)N2CC[C@@H1](NC(=O)C(C)=C(C)C)[C@H1](CC)C2 C=CCSCC(=O)N[C@@H1]1CC[C@]2(CCN(C(=O)C3=C4C(=NN3C)CCSC4)C2)C1 C#C[C@H1](NC(=O)[C@H1]1CCN(C(=O)C=CCN2CCCC2)[C@H1]1C(C)C)C3CC3 CS[C@@H1](C)CC(=O)N1CCC[C@H1](NC(=O)C2=CC=CN=C2SC3=CC=CC=C3)C1 O=C(NCCC1=NC([C@H1]2CCCO2)=N[NH1]1)NC3=CC=C4C(=C3)C(=O)NCC4 CO[C@@]1(CO)CCCN(C2=CC(N3CCC(CF)CC3)=NC(C(C)C)=N2)C1 CC[C@@H1](C)[C@H1](C(=O)NCCNC(=O)OC)N(C)C(=O)CCCCC(N)=O C/C(I)=C/C(=O)N(CC1=CC=CC(O)=C1)C2CC2 COC1C=NC=C(CNC(=O)[C@H1](CC2=CC)CC=C2C3=CC=C(OC)C=C3)[NH1]1 CN1C=CC([C@@H1](C(=O)N2CCC[C@H1](NC3=CC=CC=C3)C2)N4CCCC4)=N1 COC1=CC(C(=O)NC[C@@H1](NC(=O)C2(C)CC(C)(C)C2)C3CC3)=CC(F)=N1 CN(C)[C@@]1(C)CCN(C2=NC(=N[C@H1]3CCSC3)[NH1]C=4C=C[NH1]C2=4)C1 O=C(NC1=NC=C(C2=CC=C([N+1](=O)[O-1])N=C2)S1)C3=CC(Br)=C[NH1]3 CC(C)CCC(=O)C(=O)N1CC[C@@H1](OCCNC(=O)C2=CC=CC=C2[N+1](=O)[O-1])C1 C[C@@H1]1CC[C@@H1](C)N1[C@H1](C)C(=O)NC2(C)CN(C3=NC=CC=C3[N+1](=O)[O-1])C2 CC[C@@H1](CN(C)C(=O)CC(C)C)NC(=O)[C@H1](C)OC1=CC=C(OC)C=C1 CSCCOCC(=O)N[C@H1](CO)CCCCNC(=O)CC=1C=CSC=1 CCC(F)(F)CC(=O)N[C@H1]1C[C@@H1]1NC(=O)CCC2=CC=CC=C2N=[N+1]=[N-1] CCC1CN(C(=O)C23CCC(CC2)CO3)CCN1C(=O)C(C)C(C)C CC(=O)C1=CN(CC(=O)NC[C@@H1]2CN(C(=O)[C@H1]3C[C@H1]3F)CC24CC4)N=N1 O=C(NC1(CCCNC(=O)[C@H1]2C[C@@H1]2F)CC1)C3=CC=C(Cl)C(Cl)=C3O C=C[C@@H1]1C[C@H1]1C(=O)N[C@@H1]2CCC3(CCN(C(=O)C4=CC=NC5=C4CCC5)CC3)C2 CC(C)CCCC(=O)N1CCC(N(C)C(=O)CN(C)[C@H1]2CCSC2)CC1 C=CC=CCC(=O)N1CC[C@](CNC(=O)C(C)(C)N(C)C)(C(F)F)C1 C[C@H1](C(=O)NC1(CC(=O)N2CC=3N=CSC=3C2)CC1)C4=CC=CC=C4 CCCC(C)(CCC)C(=O)N(C)CC1(F)CCOCC1 CC[C@@](C)(CNC(=O)C1=C(Cl)C=CC(F)=C1C)NC(=O)CCC2=CC=CC=C2 C#CCOCCC(=O)N[C@@H1]1C[C@@H1](F)CN(C(=O)C2=CC=CC(C3=NN=CO3)=C2)C1 CC1=CC=NN1[C@@H1](C)C(=O)NC2(CCCNC(=O)CC=3C(C)=NN(C)C=3C)CC2 C[C@@H1](N[C@@](C)(CCBr)C1=NN=NN1CC2CC2)C3=CC=C(C(F)(F)F)C(Cl)=C3 CC(C)(C)OC(=O)N1CCC[C@](C)(C(=O)OCCC2CC3=CC=CC=C3O2)C1 O=C(C1=C[NH1]C(C2=CC=CC=N2)=N1)N3CCCCCCC3 CCC[C@H1]1CCCCN1C(=O)[C@@H1](CCOC)NC(=O)C2=NN=CC=C2C CC=1OC(C(=O)N2C[C@@H1](C)[C@@H1](CNC(=O)CN3CC(CC)C3)C2)=CC=1Br CN1C=NN=C1[C@@H1]2CCN(C(=O)C3CCC(NC(=O)CCN)CC3)C2 C[C@@H1](CCC(C)(C)C)C(=O)N1C[C@H1]2OCCN(C(=O)C=3C=NN4C=CSC=34)[C@@H1]2C1 C=C=CCCC(=O)NCC[C@H1](C)NC(=O)C=1C=NN2C=1OCCC2 C[C@@H1](CCNC(=O)C(=O)CC1=CC=CS1)NC(=O)CC=2C=NN(C)C=2 CC[C@H1](C#N)C(=O)NCC[C@@H1](C)N(C)C(=O)COC1=CC=C(SC)C=C1 CN1C(=O)CC[C@H1](NC(=O)[C@@H1]2CN(C(=O)C3CCCCC3)CC[C@@H1]2CO)C1=O C=C[C@H1](C)NC(=O)C1=CCCN(C(=O)C2=CC=CC3=NC=CN=C23)C1 CCC(CC)C(=O)NCC(=O)N[C@@H1]1CC2=CC=CC=C2[C@H1]1NC(=O)CCCC#N CC=1C=C(F)SC=1C(=O)N2CC[C@H1](NC(=O)CCCC3=CSC(=N)[NH1]3)[C@H1](C)C2 C#CC1=CC(C(=O)N2CCC[C@H1](C3CN(C(=O)[C@]4(C)CC4(F)F)C3)C2)=CC=C1C C[C@@H1](C(=O)N1CCC=2[NH1]N=C(C(=O)NCC3=CC=C[NH1]3)C=2C1)C4(O)CCC4 C[C@@H1]1C=C(C(=O)N[C@@]23CC[C@@H1](C2)N(C(=O)C4=CC(C(F)F)=CC=N4)C3)CC1 COC1=CC=CC(C2=CSC(=NC3=CC=C(OC)C=C3)N2CCCCCC#N)=C1 C#C[C@]1(NC(=O)[C@@H1](C[C@@H1](C)CC)NC(=O)C2=CN=NS2)CCCOC1 CC[C@H1](N[C@@H1](C1=CSC(C)=C1)C2=NN=NN2C3CC3)C4=NC=CS4 CN1CCOC[C@H1]1C(=O)N(CCCNC(=O)C2=CC3=CC=CC=C3N=N2)C4CC4 CC(=O)N[C@H1](C)C(=O)N1C[C@H1](C)[C@@H1](NCC2=CC(F)=C(C)C(F)=C2)C1 CC1=CC=C2SC(N[C@H1]3C[C@@H1](NC(=O)C4=CC=CN=N4)C3)=NC2=C1 CC[C@@H1](C)CCOC(=O)C1=CC=CC(CN2CCCC[C@@](C)(F)C2)=C1 C=CC[C@@H1](CC)C(=O)N(CC)CCCNC(=O)C1=CC([C@@H1](C)CC)=NO1 CCC1=C[NH1]C(C2=NC(CN3C=NC=N3)=NN2[C@@H1](C)C4CCOCC4)=C1 C[C@@H1]1CCCC[C@H1]1CC(=O)NCC2(NC(=O)C[C@@](C)(O)C(F)(F)F)CCOCC2 CO[C@@H1](CNC(=O)C(C)(C)CC(F)F)C(=O)N=C1C=CN(C(C)(C)C)[NH1]1 CN(CC(=O)NC[C@]12C[C@@H1]1CN(C(=O)C3=CSC=C3C(F)(F)F)C2)[C@H1]4CCSC4 CCN(CC1CCN(C(=O)C(C)(C)COC)CC1)C(=O)CN(C)C2CCC2 CO[C@@H1](C)CC(=O)N[C@@]1(C)CCCN(C(=O)C2=CC(Cl)=CC=C2O)C1 CSC(C)(C)C(=O)NC[C@H1]1C[C@@H1](NC(=O)C2=CC=C(OC(C)C)C=C2Cl)C1 C[C@@H1]1[C@H1](C(=O)N2CC[C@]3(CN(C(=O)CCCCC4=CN=N[NH1]4)CCO3)C2)[C@@H1]1C COCC1=NC(NC(=O)N2CCOC(CO)(CO)C2)=CC=C1Cl O=C(/C=C/C=1C=COC=1)NCCOC2CCN(C(=O)C34CCCC3CCC4)CC2 CC1=COC(CNC(=O)[C@@H1]2CC23CCN(C(=O)C4CCCCCC4)CC3)=C1 CCNS(=O)(=O)CC(=O)NCCOC1CN(C(=O)C[C@H1]2CC(C)(C)CO2)C1 CC=1N=C(C=CC(=O)N2[C@H1](CNC(=O)C(C)(Cl)Cl)C[C@@H1]3C[C@@H1]32)[NH1]C=1C C[C@@H1](C[C@@H1](C)NC(=O)C1=CC2=CC=CC=C2S1)NC(=O)[C@@H1]3C4=C[NH1]N=C4CC[C@H1]3C CC[S@](=O)CC(=O)N1CCC[C@@H1](CCNC(=O)CC2=CC=CC=C2[N+1](=O)[O-1])C1 CC=1SC(C(=O)NC23CC(C2)N(C(=O)C=CCO[C@@H1]4CCCCO4)C3)=C(C)C=1C CC1=C(Cl)C=CC([C@@H1](C(=O)O)N2CCC(C(F)(F)F)CC2)=C1Cl CC(C)(C)CC(=O)NCC(=O)NC1CN(C(=O)C2=CN=C([C@@H1]3CCCO3)S2)C1 O=C(CC=1C=NOC=1)N2CCCCC23CN(C(=O)[C@]45CC[C@@H1]4C5)C3 CCC1=C[NH1]N=C1CNC2=CC=C(S(=O)(=O)NCCNC(=O)C3CCC3)C=C2Cl CC1=CN=C(C(=O)N2C[C@H1](C)O[C@@]3(CCN(C(=O)[C@@H1]4CSC(C)=N4)C3)C2)C(C)=C1 CC1=C(C(=O)NC[C@H1](O)CNC(=O)CCN2C=CC=N2)OC3=C1C(=O)CCC3 CCCC(C)=CC(=O)N1CCC(/C=C/C(=O)N[C@@]2(CO)CC[C@@H1](C)C2)CC1 O=C(N[C@H1]1CN(C(=O)C2=CN=C3OC=CC3=C2)CC[C@H1]1F)C4=CC(Br)=CC(Br)=C4 C[C@@H1]1C[C@@H1](NC(=O)CCOCC(F)(F)F)CCN1C(=O)C2=CC=C(C(F)F)N=C2 CC1=C(C)C[C@@](C)(C(=O)N(C)CCCCNC(=O)CC2CCS(=O)(=O)CC2)CC1 COCCC1(C(=O)NCCCOCCN(C)C(=O)C2(C(F)F)CC(O)C2)CC1 N#C[C@@](C(=O)N1CCN(CC2CN(C(=O)C3(C(F)(F)F)CCC3)C2)CC1)C4CC4 C#CCCONC(=O)COC1CN(C(=O)C2=NC=C(F)C=N2)C1 CN=C(NC[C@@H1]1CCC2(COC2)O1)N[C@H1]3CCOC4(CCCC4)C3 C=CC[C@]1(NC(=O)[C@H1](C)S(N)(=O)=O)CCN(C(=O)C2=CC3=CC=CC=C3S2)C1 CC=1[NH1]C2=CC=CC=C2C=1CCN[C@@]3(C4=NN=NN4C5COC5)CCC(C)(C)C3 CC1=CC=C(C(=O)NC[C@@]2(C)CCCN(C(=O)CC3=CC=CS3)C2)C(C4CC4)=N1 CC[C@@H1](CNC(=O)C1=CC(C)=NC2=CC(F)=CC=C12)NC(=O)C=3SC(=N)[NH1]C=3C COC1=CC=CC=2C(C(=O)N[C@@H1]3CN(C(=O)CN4N=CC(Cl)=C4C)C[C@H1]3C)=N[NH1]C1=2 CC1=NC(C)=C(F)C(=NC[C@@H1]2CCCCN2C(=O)C3=CN=C(C(F)F)C(C)=C3)[NH1]1 CC(C)C1=CC=C(C(=O)N[C@@H1]2CCC[C@@H1]2NC(=O)[C@H1](C)C#N)N=C1 CC(=O)C1=NC=C(C(=O)NC[C@H1](C)CNC(=O)C2=CC=C(F)C(C(F)F)=N2)S1 C=1C=CN2C(CCNC(=O)C(=O)N3C[C@H1]4[C@H1](CN(C)C)[C@H1]4C3)=NN=C2C=1 O=C(N[C@H1]1CCN(C(=O)C2=CC=CC(F)=C2F)[C@@H1](C3CC3)C1)C4=CCCS4 O=C(NC[C@H1](O)C1=CC=CC=C1)[C@H1]2C[C@H1]3C[C@@H1]3N2C(=O)C=4C=CON=4 C[C@@H1](C(=O)N[C@@H1]1CCN(C(=O)C=2C=C[NH1]C(=N)C=2)C13CC3)N4C=CC(Br)=N4 CCC1(C(=O)O)CCN(C(=O)CCN2C=C([C@H1](C)O)N=N2)CC1 CS(=O)(=O)C1=CC=C(Br)C(C(=O)N[C@@H1](CO)CNC(=O)[C@@H1](F)C2CCC2)=C1 C[C@@H1]1CC(NC2=CC(Br)=CC=C2S(=O)(=O)NCCCN3CCC3)C[C@@H1](C)O1 O=C(C[C@@H1]1C[C@H1]1C(F)(F)F)N[C@]23CCC[C@H1]2CN(C(=O)C4=CN=CC(Cl)=C4)C3 CCCC[C@@](C)(F)C(=O)N1CC2=C(CN(C(=O)C3=C(F)C=C(CC)C=C3F)C2)C1 COC(=O)C=1C=CN(CCCC(=O)N2CCN(C(=O)CP(C)(C)=O)C[C@@H1]2C)N=1 COC1(CNC(=O)C2=CSC([N+1](=O)[O-1])=C2)CN(C(=O)C3=CC=CC=C3)C1 CC(C)CCC(=O)N[C@H1]1COCCN(C(=O)C2=C(Cl)C=C(CO)C=C2Cl)C1 C[C@](O)(CNC(=O)C[C@H1](O)CNC(=O)CC1=CC=CS1)C(F)F CCN(CCNC(=O)[C@@H1](C)C1=CC=C(C)S1)C(=O)C(F)(F)C(F)F CCCCO[C@@H1](C)C(=O)N(C)CCC1CCN(C(=O)C[C@@](C)(O)COC)CC1 CCCN1N=NN=C1[C@@H1](NCC=2C=CN(C3CC3)N=2)C4=CC(C)=C(Br)C=C4C COC[C@@H1](C)CC(=O)N1CCC2(CC1)CC(CNC(=O)CCSCC(C)C)C2 CSCCC(=O)N1CC[C@](C)(CNC(=O)C2=CC=C3N=CN=CC3=C2)C1 CC1=NOC(C)=C1[C@H1](C)NC(=O)[C@]2(NC(=O)C[C@H1]3CCC(=O)NC3)C[C@@H1](O)C2 CCNC(=O)CCC(=O)N1C[C@H1](CNC(=O)[C@@H1]2CCCS(=O)(=O)C2)[C@@H1](C)C1 CC(C)(C)[C@@H1](C#N)C(=O)N1CC(F)(CNC(=O)C2=CN([C@@H1]3CCOC3)N=N2)C1 C#CCCC(=O)N1CCCC[C@H1]1[C@H1](C)NC(=O)C2=CC=C3N=NN(C)C3=N2 CCN1C=NC(CNC2=CC(N(C)CC3=NC4=C(OC)C=CC=C4S3)=NC=N2)=N1 C[C@@H1]1[C@H1](NC(=O)[C@H1]2C[C@@](C)(O)C2)CCCN1C(=O)C3=CC=C(F)C(F)=C3F CCN(C[C@H1](C)NC(=O)CCC1=CC=NC=C1)C(=O)C2=CC(F)=C(F)C=C2F CC=1C=C(C(=O)NC[C@H1]2C[C@H1](NC(=O)[C@@H1](C)N(C)C)C2)SN=1 CCN1CCCC[C@H1]1C(=O)N2CC[C@@H1](CN(C)C(=O)C3(O)CC(C)(C)C3)C2 CCC1=CC(C(=O)N2CC[C@H1](N(C)C(=O)C3=CON=C3C4CCC4)[C@H1](C)C2)=NO1 C[C@H1](CC1=CC=NN1C)NC(=O)[C@H1](CCC2CC2)NC(=O)[C@H1]3CC(=O)C34CCC4 CC1(OCC(=O)N2CCC[C@@H1]2CNC(=O)C3=CC=C(Cl)C=C3C(F)(F)F)CCC1 CC1=NSC(C(=O)NC[C@H1](CC(C)C)NC(=O)C2=NC=C(F)C=N2)=C1N CC[C@H1](CC(=O)N[C@H1]1CCCC[C@@]12CCN(C(=O)C3(CF)CCC3)C2)OC CO[C@@H1](CNC(=O)C1(CCCF)CC1)C(=O)N[C@H1]2CC[C@@H1](C(N)=O)C2 COC1=CC(F)=CC=C1CNC(=O)C(=O)NCC2=CC(F)=C(F)C(OC)=C2 CC(C)N(CCN(C)C(=O)CCCCCNC(N)=O)C(=O)[C@@H1](F)C1CCC1 CCOC1(CC(=O)NC[C@@]2(O)CCN(C(=O)[C@@H1]3CC34CCOCC4)C2)CCC1 CC1=CC(Cl)=CC=C1OCC(=O)N2CCC([C@@H1](C)NC(=O)[C@H1]3C[C@@H1]3C)CC2 C[C@@H1]1CC(=O)NC[C@H1]1C(=O)N2CC[C@H1]2CN3C=C(C4=C[NH1]N=C4C(F)(F)F)N=N3 CC(C)N(C)C(=O)CCC(=O)N[C@]12CCCN(C(=O)[C@@]3(F)CCOC3)C[C@H1]1C2 CN(CCC1=CC=C(C(F)(F)F)C=C1)C(=O)[C@@H1]2COCC(C)(C)N2 CC1=CC=NN1CC(=O)N2C[C@H1](NC(=O)CC3(C)OCCO3)C4(CCC4)C2 CN(C(=O)C=1C=C2N(N=1)CCC2)[C@H1]3CCCCN(C(=O)CC(C)(C)C)C3 FC1CCC(N[C@H1](C2=CC=C(Br)C(Cl)=C2F)C3=NN=NN3C4=CC=CC=C4)CC1 C[C@@H1]1C[C@H1]2CN(C(=O)C(C)(C)C3=CSC=N3)C[C@H1]2N1C(=O)CSC=4N=C[NH1]N=4 CC(=C(F)C(=O)N1C[C@@H1](O)[C@@H1](CNC(=O)[C@H1](C)C(C)(F)F)C1)C2CC2 C[C@@H1]1[C@H1](C(=O)N2C[C@H1]3C[C@H1]2CC[C@H1]3NC(=O)C=CC4=CC=CC(CO)=C4)[C@@H1]1C CC1=CC=C(F)C(CN(C)[C@@H1](C(=O)NCCC#N)C2=CC=CC(I)=C2F)=C1 C=CC[C@H1](CC(=O)N(C)C[C@@H1](C)C(C)C)NC(=O)C=1C=CN(C2CC2)N=1 CC[C@@H1]1COC(C)(C)CN1C(=O)[C@H1](CCNC(=O)CCCF)OC CCCCC[C@@H1](C(=O)NC[C@@](C)(O)CNC(=O)CN1C=C(Br)C=N1)C(C)C O=C(O)[C@@H1]1CC[C@H1](C(=O)NCC2=CN(CC3=NC=CC=N3)N=N2)O1 CO[C@H1]1C[C@@H1](CCNC(=O)[C@H1](O)C2CCCCC2)N(C(=O)C[C@H1](C)SC)C1 CC(C)[C@@H1]1[C@@H1](NC(=O)CCC2=CC=CS2)CCN1C(=O)[C@@]34COC[C@@H1]3C4 COCCN(CCNC(=O)C1=CC=C(Cl)C=N1)[C@H1](C)C2=C(F)C=CC=C2F CN(C[C@H1]1CCC[C@H1]1NC(=O)C23CCN(CC2)CC3)C(=O)C4CC(=O)NC(=O)C4 C[S@@](=O)C=CC(=O)N1CCC(CCNC(=O)C2=C[NH1]C=C2Br)CC1 CCOC(=O)[C@H1](F)C(=O)N1C[C@H1](O)[C@H1](NC(=O)C2(O)CCCCC2)C1 CCCN1N=NN=C1C2(N[C@H1]3C[C@@H1](CN4C=CN=C4)C3)CCC5(CC2)CC5(F)F COC(=O)C1(C2=CC=C(NC(=O)N3CCOC[C@H1](C(C)C)C3)C=C2)CCCCC1 CC1=CN=C(N[C@@H1]2[C@H1]3CCCCC[C@H1]32)C(S(=O)(=O)NC(C)(C)[C@H1](O)C(F)F)=C1 CC1(C)[C@@H1](NC(=O)CC2=C(Cl)C=NN2C)C[C@@H1]1C(=O)NCCS(C)(=O)=O CC(C)C1=CC=C(C(=O)N[C@@H1]2CCN(C(=O)CS(=O)(=O)N3CCOCC3)C2)N=C1 CCCCC[C@@H1](O)C(=O)N1CC[C@@H1](NC2=CN=C(C(=O)OC)C=N2)C1 COCC=CC(=O)N1CC[C@@H1](NC(=O)C2(C(=O)N3CCOCC3)CC2)[C@@H1](C)C1 CC1=NN(C)C=C1CCC(=O)NC[C@H1]2CCN(C(=O)CC3=C[NH1]N=C3O)[C@H1](C)C2 O=C(NC1(CO)CN(C(=O)C2=CC=CN=C2SC(F)F)C1)[C@H1]3CCCS(=O)(=O)C3 CC(C)CN1N=CC=C1C(=O)N2CCN(C(=O)CCC3=COC=N3)[C@@H1](C(C)C)C2 CC[C@H1](O)C(=O)N[C@@]1(CNC(=O)C=CC=2SC=NC=2C)CCOC1 CC1=C[NH1]N=C1C(=O)N(C)CCCNC(=O)[C@H1]2CN(C(=O)OC(C)(C)C)C2(C)C CN1C=C(C(=O)N[C@@H1](C(=O)NCCCOCCCO)[C@H1]2CC=CCC2)N=CC1=O CN(CCC1=CC=C(Br)C=C1)C(=O)[C@H1]2C[C@@H1]2C(=O)NCCN3C=C(Br)C=N3 CN(C(=O)C[C@H1]1CCN(C(=O)CC2=CC=CS2)C1)C=3C=C[NH1]C=3 O=C(N1CCOC[C@@](F)(CNC(=O)C2(Cl)CCCCC2)C1)C3CC(F)(F)C3 CNC(=O)[C@@H1](C1=CSC(C)=C1)N2CCN(CC(F)(F)F)[C@H1](C)C2 COCC1=NC(CC(=O)N2CC(CNC(=O)C(=O)NCCNC(C)=O)C2)=CS1 O=C(NCC1CN(C(=O)C2(CF)CC2)C1)C=3C=CC4=NON=C4C=3 C[C@@H1](NC1=NC=NC2=CC=CC=C12)[C@@H1]3CN(C(=O)C=4SN=NC=4C5CC5)CCO3 CCC1=NSC(CN[C@H1](C2=CCCCCC2)C3=NN=NN3CCCF)=N1 O=C(C=1C=NN(CC(F)(F)F)N=1)N2CCCN(C(=O)C[C@@H1]3CC3(Cl)Cl)CC2 CC(C)[C@H1](CO)CCNC(=O)[C@H1]1CCC[C@@H1](NC(=O)CC(C)(C)C#N)CC1 CCC1=CC=CC=C1OCC(=O)N2C[C@H1](C)CN(C(=O)CN3N=CN=N3)C[C@@H1]2C CCC1=CC(C(=O)N(CCCN(C)C)CCNC(=O)C(F)(F)[C@@H1](O)CC)=NO1 CC1=CC([C@H1](C)NC(=O)[C@H1](CC(N)=O)NC(=O)C=2C=C(C3CC3)[NH1]N=2)=NO1 O=C(NC1=CC=NC(C2=CC(F)=CC=C2O)=C1)NC3=NC(Cl)=NC=N3 CCCNC(=O)C1=CC=CC(C2=NC([C@@H1](O)CC)=NN2C=3C=NN(C)C=3)=C1 CN(CC(C)(C)NC(=O)[C@H1]1COCC1(C)C)C(=O)C2=N[NH1]C=C2Br CC1=CC(C)=CC([C@H1](O)CN[C@H1](C2=NN=NN2CC=3N=NN(C)N=3)C4(C#N)CC4)=C1 CCC1(C(=O)N2CCC3=CC=CC=C3[C@H1](NC(=O)C4=NC=CN4C(C)C)C2)CC1 CCN1N=CC(C(=O)NC[C@H1](O)CCNC(=O)C2=CN=C(O)C(C)=C2)=C1Br O=C(N1C[C@@]2(NC(=O)[C@H1]3C[C@H1]3F)CC[C@H1]1C2)C4=NC=NC5=C4CCC5 CC[C@H1](C)[C@H1](C(=O)N1CC[C@@H1](C(=O)NC)[C@H1]1C)N(C)C(=O)C2=CN=C(O)C(C)=C2 COCC1=CSC(C(=O)NCC2CC(NC(=O)C3=N[NH1]C4=C(C)C=CC=C34)C2)=C1 C=CCC(=O)NC1(CNC(=O)/C=C/COC(C)(C)C)CC1 C=CC[C@]1(NC(=O)C[C@@H1](NC(=O)[C@@]2(C#N)CCCO2)C(F)(F)F)CCOC1 C=CC[C@]1(NC(=O)C2C[C@@H1]3COC[C@H1]3C2)CCN(C(=O)[C@H1](C)CCOC)C1 CCCCN(CC)C1=NC2=CC=CC=C2N=C1N[C@@H1]CCP(C)(C)=O CC1=C[NH1]N=C1C(=O)N2CCN(C(=O)C3=NC=NC(C)=C3C)[C@H1](C(F)F)C2 C[C@H1]C1OC[C@H1](C(=O)NCCN(C(=O)C=2C=C(C3CC3)SN=2)C4CCCCCC4)O1 CC#CC(=O)N1C[C@H1]2C[C@@H1]1[C@@H1]2C(=O)NC=3SN=C(Cl)C=3C#N COC1=CC=C(Br)C(CN2CCN(C(=O)CC3=CC=C(Cl)S3)[C@H1]4C[C@@H1]42)=C1OC C[C@@H1](NC(=O)NC1CCN(CC(=O)N(C)C)CC1)C2CS(=O)(=O)C2 C#CC1(C)CC(NC(=O)N[C@@H1](C2CC2)[C@H1]3COCCO3)C1 CC(=O)NCC(C)(C)C(=O)N1CC2(CCCN(C(=O)C[C@@H1]3CCNC3=O)C2)C1 CO[C@H1]1C[C@@H1](C(=O)N2CCO[C@@H1]3CN(C(=O)[C@@H1](C)N4C=NC(C#N)=N4)C[C@@H1]32)C1 C[C@@H1](NC(=O)C1(O)CCOCC1)C2=NC3=CC=CC=C3N2C CC1=C(C(=O)N[C@@H1]2CN(C(=O)C=C(Cl)Cl)CC23CCC3)C(C)(C)CCC1 CC1(CCC(=O)NCC[C@H1]2CSCCN2C3=NC=NC(Cl)=C3F)CC1 C#CC1=CC=C(C(=O)N(CCNC(=O)C2=NN(C)C=C2N)C3CC3)C=C1F COC1=CC(C)=C(NC(=O)N[C@H1]2CC23CCC3)C=C1OC CC[C@@H1](C(=O)N1C[C@H1](NC(=O)[C@@H1]2CNC(=O)N2)CC[C@H1]1C)C3=CC=C(F)C=C3 CC[C@@H1]1[C@@H1](C(=O)N(C)C[C@H1]2CCCCN2C(=O)CC3(CC(=O)OC)CC3)CCN1C CC=1OC=CC=1C(=O)NCC2(O)CN(C(=O)C3=CC=C4C=NN=C(O)C4=C3)C2 C1CC=2N=C(N[C@H1]3C[C@@H1](OC)C3)[NH1]C(=NC[C@@H1](C)C(C)C)C=2C1 COC1=NN(C)C=C1C(=O)N[C@H1]2C[C@](C)(NC(=O)C=3C=NN(C)C=3C(C)C)C2 CCN=C1[NH1]C(C(=O)N2CCC[C@@](C)(NC(=O)C3=C[NH1]C(C(N)=O)=C3)C2)=CS1 CCC1=N[NH1]C=C1C(=O)N2CC[C@@H1](C)[C@H1](CNC(=O)CSCCOC)C2 COCCN(C)CC(=O)N[C@H1](CCC(=O)NCC1(O)CCOCC1)C(C)C CC(C)SC1=NC=CC=C1C(=O)N(C)C[C@H1]2[C@@H1]3CN(C(=O)C4=CC(O)=CS4)C[C@H1]23 COCC(COC)CC(=O)N[C@H1](CN(C)C)C(=O)N[C@@H1]1CO[C@H1](C(F)F)C1 COC1=CC=CC(CCN=C(NCCNC(=O)C(C)(C)C)NC[C@@H1]2CCOC2)=C1 COCC1=CC(C(=O)N[C@H1]2C[C@@H1](CNC(=O)CC3=CC=C(C)C(Cl)=C3)C2)=C(C)O1 CC(C)N(CCN(C)C(=O)[C@H1]1C[C@@H1]1C)C(=O)CCC2=CC(Cl)=CS2 CCCN(CCNC(=O)C1=CC=C([N+1](=O)[O-1])C(Cl)=C1)C(=O)[C@]2(C)C[C@H1]2F CC(C)(C)C1=CC=C(C(=O)N[C@@H1](CNC(=O)CCC(F)(F)F)[C@H1]2CCOC2)C=N1 COCCC[C@H1](NC(=O)C1=CC(C)=CC(F)=C1)C(=O)NC2CC(Cl)(Cl)C2 CCC1=C[NH1]C(C(=O)N2CC([C@@H1](C)NC(=O)C3=CC=C(Br)C=C3C#N)C2)=C1 COCC=1N=N[NH1]C=1C(=O)N2CCSC[C@@H1]2CCNC(=O)[C@]34C[C@H1]3[C@H1](C)C4 CC1=CC=C(CN2N=CC=C2NC(=O)C(=O)NC[C@@H1]3CN[C@H1]4CCC[C@@H1]4O3)C=C1 CCOC(=O)N[C@@H1](C(=O)N1CC(O)(CNC(=O)[C@@H1]2C=CCCC2)C1)C(C)C CCC[C@@H1](O)CC(=O)N1[C@H1]2CC[C@H1]1CC(N(C)C(=O)[C@H1](C)C=3C(C)=NOC=3C)C2 CC=1OC=CC=1CC(=O)N2CC[C@]3(CCCN3C(=O)CSCC(F)(F)F)C2 CCCN(C)CC(C)(C)NC(=O)[C@H1](C)N(CCC)C(=O)[C@@H1](CO)OC CC(C)[C@@H1](CCNC(=O)[C@]1(NC(=O)CN(C)C)C[C@@H1](O)C1)N(C)C C[C@@H1]1O[C@H1]2CC[C@@]1(C(=O)NCC3=CC(O)=NC(CNC(=O)CC=4C=COC=4)=N3)C2 CC1=NOC(C)=C1CC(=O)NCC[C@H1]2C[C@@H1](NC(=O)C[C@H1]3CC[C@@H1]3C4CC4)C2 CNC(=O)C[C@@H1]1SC(=NC2=CC=C(F)C(F)=C2)N(CC3=CC=C(F)C=C3)C1=O CC1=NN=C(CC(=O)N[C@H1]2C[C@H1](CCNC(=O)[C@@H1](C)[C@@H1](O)C(C)C)C2)S1 CC1=CC(C)=C(C(=O)N2CCN(C(=O)C[C@H1](O)C3CC3)C[C@H1]2C)C(C)=N1 CN(C(=O)[C@@H1]1COCCO1)[C@H1]2CN(C(=O)C#CC3CCOCC3)CC2(C)C CN(C[C@@H1]1CCC1(F)F)C(=O)[C@@H1]2CN(C(=O)CC(F)(F)C(F)F)CC2(F)F C[C@@H1]1CC=CC[C@@H1]1[C@@H1](NC2COC2)C3=NN=NN3C4=CC=CC=C4Cl CO[C@H1]1CN(C(=O)C=C=C(C)C)[C@@](C)(CNC(=O)C2=CC3=NC=CN3C(O)=N2)C1 O=C(CC(Cl)Cl)N[C@@H1]1C[C@H1](O)[C@@H1](NC(=O)[C@H1]2C[C@@H1]2F)C1 C#CC[C@@]1(C(=O)N2CC(C3=CC(O)=N[NH1]3)C2)CCN(C(=O)C4CCS(=O)CC4)C1 C=CC[C@@H1](NC(=O)[C@@H1](CC#CC)NC(=O)[C@H1](F)CCCCC)C(=O)OC COC(C)(C)CCC(=O)N[C@H1]1C[C@](C)(NC(=O)C[C@H1]2COCC2(C)C)C1 C=CCCC1(C(=O)N2CCC[C@]3(CCN(C(=O)C[C@H1](O)CN(C)C)C3)CC2)CC1 CCCC[C@H1](CNC(=O)C1=CN=CC(Cl)=C1)NC(=O)C2=CN=C3N2CCOC3 COC(=O)C[C@@H1]1CC(C)(C)CN1[C@@H1](C(=O)N[C@@H1]2CCOC2)C3=CC=C(Cl)C=C3Br CC1=CC(C(=O)NC[C@H1]2CCCCN(C(=O)C=3OC=NC=3C)C2)=C(C)C=N1 CC=1SC=NC=1C(=O)N[C@H1](C)CC2CN(C(=O)C(=O)NCC(F)F)C2 CCN1C=C(CN(C)C2=NC(=N)[NH1]C(=N[C@@H1]3CCCC[C@H1]3C)[NH1]2)C=N1 N[C@H1]1[C@H1]2CC[C@H1]3[C@@H1](C2)[C@@]31C(=O)NC4=CC=CC(OCCO)=C4 C=CC[C@H1](C(=O)N1C[C@@H1](C)C[C@@H1](NC(=O)C2=CC(F)=CC=3C=COC2=3)C1)C(C)C O=C(COC=1C=CSN=1)NC[C@H1]2CC23CCN(C(=O)C=4C=C(CO)[NH1]N=4)CC3 CCCS(=O)(=O)N[C@H1]1CN(CC2=CC=CC(Br)=C2F)CC(F)(F)C1 CO[C@](C)C(=O)N1CC[C@@H1](C(=O)N2CCC[C@H1](OC3CC3)C2)C(C)(C)C1 C[C@H1]1CN(C(=O)C=CC2=CN(C)C=N2)C[C@H1]1CNC(=O)C3(C)CS(=O)(=O)C3 CC1=CC=C(S(=O)(=O)NC2CC2)C=C1C(=O)N3CC[C@@H1](OC4=CC=C(F)C=C4)C3 CC1=NC(C(=O)N2CC[C@H1]3CC[C@]32CNC(=O)C4=CC=C([N+1](=O)[O-1])C(O)=C4)=CS1 CN1CCC[C@@H1](N(C)C(=O)NC[C@H1]2CC3(CC3)S(=O)(=O)N2)C1 CCN(CCNC(=O)C1=NC=C(N)N=C1C)C(=O)[C@H1]2CC[C@H1]2C3=CC=CC=C3Cl CC1=NC(C(=O)N2CCN(C(=O)C[C@@H1](O)CC(C)C)C[C@@H1](CO)C2)=CO1 CC1=CN2C=C(C(=O)NC[C@H1]3COC[C@H1]3NC(=O)[C@H1]4C(Cl)(Cl)C45CC5)SC2=N1 CC=1N=C(C(C)C)OC=1C(=O)N2CC[C@@H1](CNC(=O)CC3(C#N)CCC3)[C@@H1](C)C2 CC(=CC(=O)N[C@]1(CO)CCN(C(=O)C(C)(C)C(N)=O)C1)C2=CC=CC(Cl)=C2 CN(C[C@@H1]1CCCN1C(=O)C#C[C@@H1]2CCOC2)C(=O)COC3CCOCC3 C#CCCC(=O)N1CCC[C@@H1](NC(=O)[C@]2(C)COC(=O)N2)[C@H1]1C COCCC1(C(=O)NCC2(CNC(=O)C3=NC=CC(OC)=C3F)CC2)CC1 O=C(NC1(CCCNC(=O)[C@@H1]2OCCC3=CC=CC=C32)CC1)C4=CC=C(O)C=N4 CC1=CN(C)C=C1C(=O)NC[C@@]2(NC(=O)C(F)(F)C3=CN(C(C)C)N=N3)CCO2 CCC1(CO)CN(C(=O)C[C@@H1]2C[C@@H1](O)CN2C(=O)[C@@H1](C)NC(C)(C)CC)C1 C[C@@H1]1C[C@H1]1CCC(=O)NCC2CC3(CCN(C(=O)C(=O)C=4C=NN(C)C=4)CC3)C2 CC1=NC([C@H1](C)NC(=O)C[C@H1]2CN(C(=O)C=CC=3C=CSC=3)CCO2)=C(C)O1 C[C@@H1]1COC[C@@H1](C(=O)N(C)CCN(C)C(=O)C=2C=C(OC(F)F)N(C)N=2)O1 C[C@@H1](CCO)C(=O)N(C)CC1CCN(C(=O)C(C)(C)O)CC1 CCCC=CC(=O)N1CC(OCC(=O)N(OC)C2CC2)C1 CC1=CC=CC2=NC=C(C(=O)N[C@H1]3CCCN(C(=O)[C@H1](C#N)C(C)(C)C)C3)N12 CCO[C@@H1](C(=O)NC(C)(C)CNC(=O)C1=C([N+1](=O)[O-1])C=NN1CC)[C@@H1]2CCOC2 CO[C@@H1]1CC[C@]2(C(=O)N3CCO[C@](C)(CNC(=O)CCC=4C=NOC=4)C3)C[C@H1]12 COC1=CC=C(CC(=O)N[C@H1](C)[C@H1](C)NC(=O)C2=CN3C(C)=NN=C3C=N2)C=N1 CCOCC(C)(C)C(=O)N(C)C[C@H1](CC)NC(=O)C1=CSC(C=2N=C[NH1]N=2)=N1 O=C(NCCC[C@H1]1CCCN1C(=O)C2=CCCCO2)C3=CC=C(C4CC4)N=C3O CCSCCC(=O)N[C@@H1]1CCN(C(=O)[C@H1](C)C[C@H1](C)C(C)=O)C12CC2 C[C@@H1]1C[C@@H1]1CCCC(=O)N2CCC(F)(C(=O)NCCN3C=C(CO)N=N3)CC2 CN1CC[C@@H1](N(C)C(=O)C2=CC=C(CNC(=O)[C@@H1](F)C3CCC3)N=C2)C1(C)C C=C1CC(C(=O)N2C[C@@H1](O)[C@H1](N(C)C(=O)C[C@@H1]3CCN4C=NC=C4C3)C2)C1 C=CC1(CC(=O)N[C@@H1]2C[C@H1]3[C@@H1](C2)C3(F)F)CN(C(=O)[C@@H1](C)[C@@H1](O)CC(C)C)C1 CC(C)(C)/C=C/C(=O)N1CCC[C@@H1]1CCCNC(=O)[C@H1]2CCCSC2 CCC1=CC(C(=O)N[C@H1](C)C(C)(C)C(=O)N[C@@]23CC[C@@H1](C2)[C@H1](O)[C@@H1]3O)=NS1 CN(CCNC(=O)C[C@H1]1CN(C(=O)[C@H1]2CCC2(F)F)C(C)(C)C1)CC(F)F CSC=CC(=O)NCC(C)(C)CNC(=O)C(C)(C)CCCN=[N+1]=[N-1] O=C(NC1[C@H1]CCN(C(=O)C2=CN=N[NH1]2)CC[C@@H1]1CO)C=3OC=C4C=3CCOC4 COC1=CC=C(C(=O)N[C@@H1](C)[C@@H1]2CCCN(C(=O)C3=CN(C)C=N3)C2)C=N1 CSC1=CC(N)=CC=C1C(=O)NCC2=CC=C(S(=O)(=O)N(C)C)C=C2 CC1(C)CN([C@H1]2CCCN(C[C@H1](O)C(F)F)C2=O)C(=O)O1 C=CN1N=CC=C1C(=O)NC(C)(C)CCCC(=O)N2CC[C@@H1](N(C)C)[C@H1](C)C2 CC[C@@](O)(CC(=O)NCCC1=CCN(C(=O)[C@H1](C)N(C)C)CC1)C2=CC=CC=C2 NC(=O)C1=CC(F)=CC(C(=O)NCCC2(NC(=O)[C@@H1]3NC(=O)[C@@H1]4C[C@@H1]43)CC2)=C1 COC(=O)[C@H1](OC)C(=O)N1CCC[C@@H1](NC(=O)C2=CC=CC3=CC=C(C)N=C23)C1 N#CC1=CC=C(CNC(=O)C2CC3(CC(NC(=O)C4=CC(Cl)=CN=C4Cl)C3)C2)S1 CN(CC1(NC(=O)[C@H1]2CCOC2(C)C)CC1)C(=O)C3=CON=C3C(F)(F)F CC=CCC(=O)N1C[C@H1](NC(=O)CC2(C)OC3=CC=CC=C3O2)C[C@]1(C)COC CN(C)NC(=O)CCC(=O)N1C[C@H1](NC(=O)C2=CC=C(C3CC3)C=N2)C4(CC4)C1 CN1C=NC(NC[C@H1]2CN(C(=O)C3=CN(CC(N)=O)N=N3)CCO2)=C(Br)C1=O CC(C)[C@H1](C(=O)N1CC[C@@H1]1C(=O)NC2=CN(C)N=C2C(N)=O)C3=CC=C(Cl)C=C3 CC[C@H1](C#N)C(=O)NC1(C2=CC=CC=C2)CN(C(=O)C3=CSN=C3OC)C1 CCC[C@H1](NC(=O)C1=N[NH1]C=C1CC)C(=O)NCCCN2C=CN=N2 O=C(CN1CCC[C@@H1]1CO)NCCCCCCNC(=O)C2CC3(C2)C(F)(F)C34CC4 CCN1C[C@@H1](C(=O)N2CCCC[C@@H1](N(C)C(=O)C3=CC=CC(=O)N3C)C2)CC1=O C=CC[C@H1](CC(=O)N1[C@H1](CO)C[C@H1]1C)NC(=O)[C@H1]2CC[C@@H1]2C(C)(C)C CCCC[S@](=O)C1=CC=C(C2=CC=C(C(=O)NCC3CN(C)C3)N=C2)C=C1 CCC1=NC=C(C(=O)N[C@H1](CCOC)C(=O)N(C)[C@H1](CC)C(F)(F)F)S1 C[C@H1](NC(=O)C1CCSCC1)C2=NOC=C2C(=O)NC3([C@H1]4CCCO4)CC3 N#CC[C@H1]1C[C@H1](NC(=O)C2=CC=C(O)N=C2)C1 CC(C)(C)CC(=O)N[C@@H1]1C[C@H1](CNC(=O)C(=O)C=2C=NN(C(C)(C)C)C=2)C[C@H1]1O O=C(N1CCC[C@@H1]1CN=C2N=C(C3CC3)[NH1]S2)C4CCCC4 CC1=NSC(C)=C1CN(C)CCN(C(=O)CCC(C)(C)C)C(C)C CCN=C1C=C(C=2N=C(C3=CC=C4[NH1]C=CC4=C3)N([C@H1]5CCSC5)N=2)C=C[NH1]1 C#CCSCC(=O)N[C@@H1]1CCSC12CN(C(=O)C3=C[NH1]C=CC3=N)C2 CC=1C=C(P(C)(C)=O)OC=1C(=O)N2CC3(CCC[C@@H1]3NC(=O)[C@H1]4CC45CC5)C2 C[C@@H1](NC(=O)NNC(=O)CCCO)C1=CC=C(C(F)(F)F)C(Cl)=C1 CC=CC(=O)N1CC[C@@]1(C)CC(=O)NCCN2CC[C@H1]3C[C@H1]32 CN1C=C(Cl)C(C(=O)N2C[C@H1]3[C@H1](NC(=O)C4(F)[C@@H1]5CCC[C@H1]54)[C@H1]3C2)=N1 CC[C@H1](C)[C@@H1](C(=O)N1CC(C[C@@H1](F)C(=O)NC2(C3CCCC3)CCC2)C1)N(C)C C[C@@H1](NC(=O)C1CC1)C(=O)N2CCCC[C@@H1]2C(=O)NC3CC4(CCCO4)C3 CC[C@H1](C)/C=C/C(=O)NCC(=O)N1CCN(C(=O)[C@H1]2CCCN2C(C)C)CC1 COC(=O)[C@H1](CNC(=O)[C@H1]1CCCN1C(=O)CC[C@H1]2CCOC2)OC CCC1=CC(C(=O)NC[C@H1](NC(=O)CC=2C=COC=2C)[C@@H1]3CCOC3)=N[NH1]1 CC1=NN=CC=C1C(=O)NC[C@H1]2CCN(C(=O)C=CCF)C[C@H1]2C C=CC[C@@](C)(CO)CNC(=O)C1=CON=C1[C@@H1](C)NC(=O)C2(F)CCOCC2 O=C(CSC1=CC=C(F)C=C1)N[C@@H1]2CN(C3=NC=CC=N3)CCC24CCOCC4 CCCCC[C@@H1](O)C(=O)NC[C@@H1]1COC[C@H1]1NC(=O)C(C)(C)CC C[C@@H1](NC(=O)C1=CC=C(N)C(Cl)=C1)C2CCN(C(=O)CC3=CC=CC(F)=C3)CC2 C[C@]1(CN)CC[C@@H1](NCCC[C@@]23CC[C@@H1](C2)C(=O)N3)C1 CC1=C(C(=O)N2C[C@@H1](C)[C@H1](CNC(=O)C3=CN=CC(N)=C3)C2)C=NN1C4CC4 C#CCCCC(=O)N(C)CCC(=O)NC[C@@H1]1CCC[C@H1]1CF CCOC=CC(=O)N1C[C@@H1](CNC(=O)[C@@H1](O)CC2CCOCC2)C(C)(C)C1 CCC(CC)[C@H1](NC(=O)[C@](C)(O)[C@@H1](C)O)C1=CC=CS1 CC1=CC=C(SCC(=O)NCC[C@H1]2CCCN(C(=O)[C@H1]3CCC=CO3)CC2)C=C1 O=C(C1=CC=CC=2C=NSC1=2)N3CC[C@]4(CCCN4C5=CC(F)=NC=N5)C3 CC(C)N1C=C(C(=O)N2CC[C@@H1]2CNC(=O)[C@]3(C)CCCO3)C=CC1=O COC[C@H1](O)C(=O)N[C@H1](C)CN1CCN(C(=O)CC2=C(O)N=CN=C2O)CC1 CCCCCCCCC(=O)N1CC[C@@H1](C)[C@@H1](NC(=O)C2=COCC2)C1 C#CC1=CC=C(OC)C(C(=O)N[C@@H1]2C[C@H1]2CNC(=O)C(F)(F)[C@H1](O)CC)=C1 C[C@H1](C(=O)N1CCC[C@H1]1C2(NC(=O)C=3C=N[NH1]C=3)CC2)C4=CC=C(Br)S4 CCSCC(=O)N[C@H1]1C[C@@H1]1NC(=O)[C@@H1]2CC(C3=CC=CC(OC)=C3)=NO2 CCOC[C@@H1](NC(=O)C=1C=CN(C)C(=O)C=1)C(=O)N2[C@H1]3COC[C@H1]2C3 C=C1CCN(C(=O)C2=CC=C(O)C=C2F)[C@@H1](C(=O)N[C@@H1](C)CN(CC)CC)C1 COCC[S@](=O)C1=CC=C(CC(=O)N[C@H1](C(=O)OC)C2=CC=NN2C)C=C1 CCOCCOCCC(=O)NC[C@H1]1C[C@@H1](C(=O)N(C)CCC2=CC=CS2)CO1 N#CC1=CC=CC(C(=O)N[C@H1]2CCC[C@H1]2NC(=O)COC3=CN=CC(Cl)=N3)=C1F CCOCCOC1=CC=CC(C2=NC(C[C@H1](C)CC)=NN2CCC(C)C)=C1 CCCN(C(=O)COCCSC)[C@@H1](C)C(=O)N(C)CCOC C=CCC1(C(=O)NC[C@H1]2CN(C(=O)C=CC=CC)CCC23CCC3)CC1 C[C@H1](C(=O)N1CC[C@@H1](C2=CN=N[NH1]2)C1)N(C(=O)C[C@@H1]3CCCC(=O)C3)C4CC4 CC(C)OCC(=O)N1CC[C@H1]2CCN(C(=O)C=3C=CC(=O)N(C4CC4)C=3)[C@H1]2C1 CCN(CCNC(=O)C[C@@H1]1CCCC(=O)C1)C(=O)C2=CC=CC(OC)=N2 CN1C[C@@H1](O)C[C@H1]1C(=O)N2CCC[C@@]23CCCN(C(=O)CNC(=O)C(C)(C)C)C3 CN(C)CC(=O)N1CCC(CC2CCN(C(=O)C3CC4(C3)CS(=O)(=O)C4)CC2)C1 CCN(C)CCNC(=O)[C@@]1(F)CCN(C(=O)C2=NON=C2N)C1 O=C(NC[C@H1]1C[C@@H1]2CC[C@H1](C1)N2C(=O)CC3OCCO3)C=4C=NN(C(F)F)C=4 CC1=CC(C(=O)NC[C@H1](F)CNC(=O)[C@]2(C)C=CCCC2)=CC(C)=C1C CC(=O)N1CC[C@H1](F)[C@H1](NC2=NC=NC=3OC=CC2=3)C1 CC1(C)CCC[C@](CO)(NC(=O)C(=O)N2CCC(OCCC3CCCC3)CC2)C1 C=C(Cl)CCC(=O)N1CCC[C@@H1]1[C@@H1]2CCCN(C(=O)CCC(=C)C)C2 CN1C=CC(C(=O)N2CC[C@H1]3CN(C(=O)C4=NC=C[NH1]4)CC[C@@H1]3C2)=C(O)C1=O C[C@H1](C(=O)NC[C@]1(C)COCCN(C(=O)C2=C(Cl)C=NN2C)C1)N3CCC3 CC1=C[NH1]N=C1C(=O)N[C@@H1](C)C2(O)CN(C(=O)CSC3=N[NH1]C(=N)S3)C2 CC[C@@H1](OC)C(=O)N1CCOC2(CN(C(=O)[C@@H1](C)OCCC3=CC=CC=C3)C2)C1 CC1=NC=C(C(=O)NCCC2=NN=C(C3=CC=CC(Br)=C3)O2)N1C4=CC=CC=C4 O=C(NCC1(O)CC(NC(=O)[C@@H1]2CCC[C@H1](O)C2)C1)C3CCN(C4CC4)CC3 CCC1=NC(Cl)=C(F)C(=NC[C@@H1](NC(=O)CC2=CC=CC=C2Cl)C(C)(C)C)[NH1]1 C[C@@H1](CC(=O)NCCCN(C(=O)C1=CSC=C1Cl)C2CC2)N3C=CC=N3 CC(C)CCSCC(=O)N[C@H1]1CCN(C(=O)CCCC(C)(C)C)[C@@H1]1C(C)C CC1=CSC(CNCCN2CCN(C(=O)[C@@H1]3C[C@H1]3C4CC4)CC2)=C1 C=CCCN1C=C(C(=O)N2CC[C@](F)(CNC(=O)[C@H1]3C[C@@H1]3C)C2)N=N1 CC[C@@H1](N[C@@H1](C1=CC(Cl)=NN1C)C2=NN=NN2CC3=CC=CC=C3)C4=CC=CS4 CNC1=NC=CC=C1C(=O)N[C@H1]2CN(C(=O)[C@H1](C)SC3=CC=CC=N3)C[C@@H1]2C C[C@@H1](CCNC(=O)[C@H1](C)CC1=CC=CC=C1)NC(=O)CC2=CN(C)N=C2Cl C=CCSCC(=O)NC[C@@]12C[C@@H1]1CN(C(=O)C3=CC(C(F)F)=CC=C3Cl)C2 COC[C@@H1](C#N)NC(=O)[C@]1(C)CCCN1C(=O)OCC2=CC=CC=C2 CC1=CC=NC([C@H1](N[C@H1](C)C2=CC=C(Br)C(C)=C2)C3=NN=NN3C4CC4)=N1 CCC1=CC(C(=O)N2CC[C@@H1](N(CCO)C(=O)C=3C=C(CC)ON=3)C2)=NN1C C[C@@H1]1CC=C(C(=O)NC[C@H1](NC(=O)C2=CSC(Cl)=N2)C3=CC=CC(Cl)=C3Cl)CC1 C[C@@H1](CNC(=O)C1=CSC(O)=N1)[C@]2(O)CCN(C(=O)[C@@H1]3C[C@@H1]4C=C[C@H1]3CC4)C2 CC(C)C[C@@H1](CNC(=O)C=1C=C2N(N=1)CCNC2=O)NC(=O)C3=C(Cl)CC3 CN(CC(=O)N1CC2(C[C@H1](NC(=O)C3=CC=CC=4C=COC3=4)CO2)C1)C5CCC5 CC=C(CC)C(=O)N[C@@H1]1CCCCN(C(=O)CCSC2=CC=CC=C2)CC1 CC(C)(C)[C@H1]1[C@H1](NC(=O)C2=NOCC2)CCN1C(=O)C=3C=CC4=NC=NN4N=3 CCN(CCNC(=O)[C@](C)(O)[C@@H1](C)C1=CC=CC=C1)C(=O)C2=CC=NC=C2SC COC1=CC(C)=CC=C1C(=O)N2C[C@H1]3CC[C@H1]2[C@H1](NC(=O)CCSC(F)(F)F)C3 CCCC[C@H1]1CN(C(=O)C2=C(Br)C=NN2CCC)CCN1C(=O)[C@H1]3CC3(C)C CO[C@@H1]1CC[C@H1]1NC(=NCCF)NC[C@H1](C2=CC=C(N(C)C)C=C2)N(C)C CC=1C=NN([C@H1](C)C(=O)N[C@@H1]2C[C@H1]3CC[C@H1]2CN3C(=O)C[C@H1](C)C(C)C)C=1 C#C[C@H1](CC)CNC(=O)[C@@H1]1C[C@H1](NC(=O)C(F)(F)C2CC2)CCO1 C=C(CCNC(=O)[C@]1(COC)CCC(=O)N1)CNC(=O)[C@@H1](F)C2(O)CCCC2 CCCC[C@H1](C)CCC(=O)N1CCC2(CC1)C[C@H1](OC)CN2C(=O)C(N)=O CS[C@@H1](C(=O)N1CCN(C(=O)COCC2=CC=NN2C)[C@H1](C)C1)C3=CC=CC=C3 CC1=CC(C)=C(C(=O)N2[C@H1]3C[C@H1]2CN(C(=O)C[C@@H1]4CCO[C@@H1]4C)C3)C(O)=N1 O=C(CC1=CC=C2C(=C1)CCO2)NC3(C(=O)O)CSC3 C=C1CC[C@H1]1C(=O)N[C@H1](C)CN(C)C(=O)C2=COC3=C2C(=O)CCC3 NS(=O)(=O)C1=CC(C(=O)NC[C@@]2(O)CCCN(C(=O)C3(O)CCC3)C2)=CC=N1 CC1=CC=C(C(=O)N2C[C@H1](NC(=O)CN(C)C3CCCC3)[C@@H1]4C[C@H1]42)[NH1]1 C[C@@H1](NC(=O)[C@@H1]1CC2(CCN1)CC2)C3=CN(C4=CC=C(Cl)C=C4Cl)N=N3 CN(C[C@H1]1CCN(C(=O)C=2C=CN(C3CC3)N=2)C1)C(=O)C[C@H1]4NC(=O)CNC4=O CN(C[C@@H1]1C[C@H1](F)CN1C(=O)C2=C(Cl)C=NN2C)C(=O)[C@@H1]3CCOC3=O CC[C@H1](O)C(=O)N[C@@]1(C)CCN(C(=O)C2=CN3C(=N2)SCC3)C1 C=C[C@H1](O)C(=O)N[C@@H1]1CCN(C(=O)C2=C(Cl)C=CC=C2OC)C[C@H1]1CO CC(C)(CNC(=O)[C@H1](O)CC(F)(F)F)OCC(=O)NC[C@H1]1CCCC[C@@H1](O)C1 CC[C@@](C)(O)C(=O)N1CCC[C@@H1](N(C)C(=O)CN2C=C(C(=O)OC)N=N2)C1 CCOC(=O)C1=NC(N[C@@H1]2CCCC3=C[NH1]C=CC32)=NC4=CC=CC=C14 CC(=O)N1CCO[C@@H1]2CN(C(=O)CCC3=NC=C(C4=CC=CC=C4)O3)C[C@H1]21 CCCCC[C@@H1](F)C(=O)N1CCN(C(=O)C2(O)CCOCC2)C[C@H1]1C CC(C)C[C@@](C)(CO)NC(=O)C1=CC[C@H1](NC(=O)CCC2=CC=CN2C)C1 CCC1=CC=C(C(=O)N2CC[C@@H1](C(C)(C)C(=O)N3CC[C@H1]4CCC[C@H1]4C3)C2)C=C1 CNC(=O)N[C@@H1](C)C(=O)N1CC[C@H1](NC(=O)C2=CC=NN2C)[C@@H1](C)C1 CC1=CC=C(CNC(=O)C[C@@H1]2CC3(CC3)CN2C(=O)[C@@H1]4CC[C@H1](C)O4)C(F)=C1 CO[C@H1](CNC(=O)C1=CCN(C(=O)[C@@H1]2CC[C@H1]2C#N)C1)CC3CC3 C=CCCC1(C(=O)NCCN2C=C(C)C=N2)CN(C(=O)CCC3=CN=N[NH1]3)C1 CC1=CC=C(C(=O)N[C@@H1](C)C[C@H1](C)NC(=O)C2=CC3=NC=CC=C3S2)C=C1Cl CC(C)(C)OCCOCCC(=O)N[C@H1]1C[C@@H1](NC(=O)C2=C[NH1]C(C(F)(F)F)=C2)C1 CC[C@H1](C)[C@@H1](C)C(=O)N(CC)CCNC(=O)C1=CC=C(C(=O)OC)C=C1C C[C@H1](NS(C)(=O)=O)C(=O)NC1CCC(N2CCN(C3=NC(O)=N[NH1]3)CC2)CC1 NC(=O)C1=CC=CC(C(=O)N2CC[C@@H1]2CNC(=O)[C@@H1]3COC4(CCC4)C3)=N1 CCN1CC[C@H1]1C(=O)NC2(CCNC(=O)[C@H1]3COCCN3CC(F)F)CC2 C=C(C)COCCNC(=O)/C=C/CN(C)C(=O)CCC1=NC(=N)[NH1][NH1]1 CC[C@@H1]1C[C@H1]1C(=O)N[C@@H1]2COC[C@@H1]2NC(=O)C3=CN(C4=CC=CC=C4)N=C3C CCOC(CC(=O)NCC(C)(C)CN1C=C(CC2CCC2)N=N1)OCC CCC(=O)N[C@@H1](C)C(=O)N(C)C[C@H1]1CCN(C(=O)/C=C/C2=CC=C(Cl)C=C2F)C1 CN1N=CC(C(=O)NC[C@H1]2CCC[C@H1]2NC(=O)[C@]3(C)CCCCC3(F)F)=CC1=O CON(C)S(=O)(=O)C1=CC=C(C(=O)N2CC[C@H1]3C[C@H1]2C(=O)N3C)C=C1 CC[C@H1](O)CCC1=CN(CCN(C)C(=O)CSC2=NC=NC=N[NH1]C=C2)N=N1 C=CC(C)(C)C(=O)NC[C@H1]1C[C@H1]1NC(=O)CC=NN2C(C3=CC=CC=C3)=CC=N2 C[C@H1]1C[C@@H1](C(=O)NC[C@@H1]2C[C@H1]2C3=CC=CO3)CN(C(=O)CNC(=O)CN(C)C)C1 C[C@@H1](CCC(C)(C)C)NCC1=NC(C(=O)O)=CS1 CCC1=NC(=N)[NH1]C=C1C(=O)NCC2CN(C(=O)C3=CN=CC4=C3CCC4)C2 CC[C@@H1](F)C(=O)N1CCC2(CC1)OC3(C)CC2(NC(=O)C4=CN=NN4CC)C3 CC=1C=C(CC(=O)N2C[C@H1](C)C(NC(=O)C3CCC(C(C)C)(O)C3)[C@@H1](C)C2)SN=1 CNC(=O)[C@@H1](C1=NC(C)=CO1)N2C[C@H1]3C[C@@H1](C2)C4=CC=CC=C43 COC(=O)C1=CC=C(CC(=O)NCC[C@H1](C)NC(=O)C=2C(C)=NSC=2C)C(C)=C1 C[C@H1]1CC[C@@H1](CNC(=O)CC(F)(F)Cl)CN1C(=O)CCCNC(N)=O C[C@H1](CC(=O)NCC[C@H1]1CCCN(C(=O)COC=2C=N[NH1]C=2)CC1)N(C)C CC1=NC=CC(C(=O)N2CCC[C@@H1]2CNC(=O)C3=CC(=N)[NH1]C(Cl)=N3)=C1C COCCC1(C(=O)N2CCN(C(=O)CSC(F)F)[C@@H1](C(F)F)C2)CC1 C[C@H1]1CC[C@H1](CC(=O)NC[C@H1](NC(=O)CNS(=O)(=O)N(C)C)C2CCCC2)OC1 CC1(C#CC(=O)N2CC(C)(C)CC[C@H1]2CNC(=O)[C@@H1]3CCC(=O)N3)COC1 CC1=CC(C(=O)N2CCC(C)(NC(=O)CCC=3C=NN(C)C=3C)CC2)=NC(O)=N1 C[C@@H1](NC(N)=O)C(=O)N[C@H1]1C[C@@H1](NC(=O)C=2C=C(C3CC3)ON=2)C1 CC(C)=C(C)C(=O)N1CC[C@@H1](CNC(=O)C2(CC3=CC=CN=C3)CC2)C14CCC4 CCCC(C)(C)CC(=O)NC[C@@H1]1C[C@@H1](OC)CN1C(=O)[C@H1](O)C2CC2 COC[C@H1](C(=O)NC[C@H1]1C[C@H1]1C(=O)N[C@@H1](C)C2=CC=C(C)C=C2)N(C)C COCCN(C(C)=O)C1=NC(CN[C@@H1](C)[C@@H1](CO)SC)=CS1 OCC[C@H1]1CCCCN1C2=NC=NC3=C(Cl)C=C(Cl)C=C23 CCN1C=C(C(=O)N[C@H1]2CCCN(C(=O)C3=CC(N)=C(C(=O)OC)S3)CC2)N=N1 C=C(Cl)CCC(=O)N1CCC[C@]2(CCN(C(=O)[C@@H1]3C[C@H1]3C=4C=N[NH1]C=4)C2)C1 CC=1N=C(O)[NH1]C=1C(=O)NC[C@H1](NC(=O)C2=CN=CN2C3CC3)[C@H1](C)C(C)C [N-1]=[N+1]=N[C@H1]1CC[C@H1](C(=O)N2CC[C@H1](CNC(=O)C3(CO)CC3)C(F)(F)CC2)CC1 CCC=1N=C(C)[NH1]C=1C(=O)N2CCCC[C@@H1](NC(=O)C=3SC=CC=3C4CC4)CC2 CC1(CCC(=O)N2CCC3(CC2)C[C@@H1]3CNC(=O)C4CC=CC4)N=N1 C[C@@]1(CN=C2[NH1]C3=CC=C(S(=O)(=O)NC4(CCF)CC4)C=C3S2)CCCO1 C#CCN(CCC(=O)NC[C@@H1](C)C1=CC=CC=C1)C(=O)C[C@@H1]2CCC(=O)N2C CN(CC1(O)CN(C(=O)[C@@H1](CCO)N(C)C)C1)C(=O)CCC(=O)OC(C)(C)C O=C(CCN1C=CC=N1)N[C@H1]2C[C@](F)(CNC3=NC=NC=4C=C(Br)SC3=4)C2 COC(=O)[C@@H1]1CSCCN(C(=O)C(=O)N[C@H1]2CCN(C3=CC=CC(Br)=C3OC)C2)C1 CC(F)(F)CC(=O)N1CCC(C(C)(C)NC(=O)[C@@H1](F)OC2=CC=C(Cl)C(F)=C2)C1 CS[C@H1](C)[C@H1](C)NC(=O)C1=CC(CNC(=O)CC[C@H1](C)N(C)C)=NO1 CCC[C@H1](O)C(=O)N[C@H1]1C[C@]2(C(=O)N=C3C=C(C(N)=O)N(C)[NH1]3)CO[C@H1]1C2 COC1(C(=O)N2CCO[C@@H1](CNC(=O)CSC3=NN=CN3C)CC2)CCOCC1 O=C(CC1OCCCO1)N[C@@H1]2CO[C@@]3(CCN(C(=O)CSC(F)(F)F)C3)C2 O=C(NCC[C@@H1]1CCCN(C(=O)C=2C=CON=2)C1)[C@H1]3CC4=CC=C(F)C=C4O3 C#CC1=CC=CC=C1CC(=O)N[C@H1](C(=O)N[C@H1]2CC23CCOCC3)C(C)C C[C@H1]1CN(C(=O)CSCC2=CC=CN=C2)CC[C@@H1]1CNC(=O)CCC3OCCO3 CC(C)(C)CCCCC(=O)N[C@@H1](C(=O)NCCCC1=CN=CN=C1)C2(O)CCC2 CC[C@H1](CNC(=O)C1=CC=C(C)C=C1Cl)NC(=O)C2=CC=C(OC)N=N2 C[C@@]1(C2=CC=CC(C(=O)NC[C@@H1](F)CNC(=O)C3=C(Cl)CCOC3)=C2)CCO1 CC[C@H1]1CC[C@@H1](CNC(=O)C2(CNC(=O)C[C@H1]3CCSC3)CCC(C)CC2)O1 COCC1=NC=C(NC(=O)C2(CCNC(=O)C[C@@H1]3C[C@H1]4CC[C@H1]3C4)CC2)C=N1 O=C(C1=CC=C2N=C(C(F)(F)F)SC2=C1)N3[C@H1]4CC[C@H1]3C[S@@](=O)CC4 COC(=O)C(C)(C)CC(=O)NC[C@H1](CNC(=O)[C@H1]1CCOC(C)(C)C1)OC CCC1CCC([C@H1](C(=O)NCC2CC2)NC[C@H1](C3=CC=CC=C3)C(C)C)CC1 COC(=O)[C@@H1](NC(=O)/C(C)=C/CNC(=O)C1=CN(C)C=C1C)C2(C)CC2 CCS(=O)(=O)C1=CC=C(OC)C(C(=O)N(C)C2CCC(NC(=O)CSC)CC2)=C1 CN=C(NCC[C@](C)(O)C1=CC=CC=C1)NC[C@H1]2CCCS2 CC[C@@H1](NC(N)=O)C(=O)N[C@@H1](C)CN1C=C(C(C)(C)NS(C)(=O)=O)N=N1 CCOC(=O)C1(C(=O)NCC23CC(NC(=O)C4=NN=C(S)N4C)(CO2)C3)CC1 CCN(CC=1OC=CC=1C)C(=O)[C@@H1]2CCN(C(=O)[C@H1](C)C3=CC=CS3)C24CCC4 CC(C)[C@@H1](CNC(=O)CCC1=NC=NN1C)NC(=O)C2=CC3=CC(Cl)=CN=C3[NH1]2 O=S(=O)(NC1=CC=CC(C(F)(F)F)=C1)C2=CC=C(C3=CC(O)=N[NH1]3)C=C2 CC1=CC=NC(C(=O)N2C[C@@H1](F)C[C@H1]2CNC(=O)CN(C)C(=O)OC(C)(C)C)=C1 CCO[C@H1](C)C(=O)N1CCO[C@H1](CCNC(=O)C2=CN=CC=3C=CSC2=3)C1 CC1=NC(CCC(=O)N2C[C@@H1](O)[C@H1](NC(=O)[C@@H1]3[C@H1]4CC[C@H1]5[C@@H1](C4)C[C@H1]53)C2)=CS1 COC1=C(C(=O)N2C[C@@H1]3CC[C@H1](C2)C3N4CC[C@H1](OC)C4)C=CC(Cl)=C1Cl COCC(=O)N(C)[C@H1]1CCCN(C(=O)C2=CN(C3=CC=C(Cl)C=C3)N=N2)C1 CC(C)C[C@@](C)(O)C(=O)N1CCC([C@H1](C)CNC(=O)C=2C=NN(C3CC3)C=2)CC1 COC/C(C)=C/C(=O)N1CC[C@](COC)(NC(=O)[C@@H1]2C[C@@H1](F)C(=O)N2C)C1 CC1(C)OC2=CC=C(C(=O)N[C@H1]3CCN(C(=O)C4=COC(Cl)=N4)C[C@@H1]3F)C=C2O1 CCCC[C@H1](CC)C(=O)N1CCC[C@H1]1CNC(=O)C2OCCO2 CCC1=NC(C(=O)N[C@H1](C)[C@@H1](C)C(=O)NC2=CN=CN=C2C(=O)OC)=CS1 CO[C@@]1(C(=O)N2C[C@H1]3[C@H1](CNC(=O)C=4C=C[NH1]C(=N)N=4)[C@H1]3C2)CCOC1 C[C@@H1](CC1=CC=C(N)C=C1)C(=O)NC2CN(C(=O)C[C@@H1]3CCOC(C)(C)C3)C2 CCN1C=C2C=CC(CN=C3C=CN=C(N4C[C@@H1](C)N(C)[C@H1](C)C4)[NH1]3)=CC2=N1 O=C(NC[C@]12C[C@@H1]1CN(C(=O)CC=3N=CN4C=3COCC4)C2)[C@@H1]5CC56CC(O)C6 CC=1[NH1]N=C(C(=O)N[C@H1]2CCCC[C@H1]2NC(=O)C3=COCCC3)C=1Br CC1=CC(C(=O)N2C[C@@H1](NC(=O)C3=C[NH1]C(C)=C3)C(F)(F)C2)=C(O)N=C1C CO[C@H1](CNC(=O)C[C@@H1]1CN(C(=O)[C@@]23CC[C@@H1](C2)O[C@H1]3C)C[C@H1]1C)C4CC4 CCCCOCCN=C1[NH1]C(=NC[C@H1]2CCC3=NC=CN32)C4=CC=C(C)C=C4[NH1]1 CCC1=CC(C(=O)N2CC[C@H1]3CC[C@]32CNC(=O)CC(F)F)=NC=N1 CNC(=O)N[C@@H1](C)C(=O)N1CC=C[C@@H1](NC(=O)[C@H1]2CC(C3CCOCC3)=NO2)C1 CC1=CC(C(=O)N2CC[C@H1](C(=O)N(C)[C@@H1]3CCO[C@@H1](C)C3)[C@H1]2C(C)C)=NC(C)=N1 CNC(=O)N[C@H1](C)C(=O)NC[C@@H1]1CC[C@H1](NC(=O)CC2=NNC(=O)C2)C1 CSCCC(=O)NCC1(F)CN(C(=O)C2=CC=C(S(C)(=O)=O)C=C2)C1 CN1C[C@H1](C(=O)OCCC[C@H1]2C[C@H1]2C)CC1=O CC[C@@]1(C)C[C@H1](NC(=O)C(C)(Cl)Cl)CN1C(=O)CC/C=C/C(C)C CC[C@@H1](O)[C@H1](C)NC(=O)C(=O)NC1=CC(C)=C(C)C(C)=C1 COCCN(C)CCCNC(=O)C(=O)NCC12CC(C[C@@H1]1CO)C2 CCC1(C(=O)N[C@H1]2CCCC[C@H1]2NC(=O)C3=NC(C4CC4)=NC=C3Cl)CCCC1 O=C(NC1=CN=C2[NH1]C=NC2=C1)[C@H1]3C[C@@H1](NS(=O)(=O)C4=CC=CC=5SC=NC4=5)C3 CN1CC[C@H1](C(=O)N[C@@H1](CNC(=O)C2=CN=C3N2CCCC3)C4CC4)S1(=O)=O CC1=CC=CC2=C(C(=O)NC3(CNC(=O)[C@@H1]4C[C@@H1]5CC[C@@H1]5C4)CCC3)C=NN12 CCC1=NN=C(CN=C2[NH1]C3=C(C(=N[C@@H1](CC)C4=NC=CC=N4)[NH1]2)CSC3)S1 CCNC(=O)C(=O)NCC1(C)CC(NC(=O)C2(C3=CC=C(Cl)C=C3)CC2)C1 O=C1CCN(C[C@@H1]2COCC23CCC3)C(=O)[C@@H1](CNC(=O)C4CC=CC4)C1 CCOC=1C=C(C(=O)N2C[C@@H1](NC(=O)C3=CC(C)=CC4=C3OCC4)C[C@@H1]2C)ON=1 CC(C)N1N=C(C(=O)N2C[C@@H1](C)[C@@H1](CNC(=O)CC3=CN=NN3C)C2)CCC1=O CC(C)N(CCN(C)C1=NC=C(C#N)C=C1Br)C(=O)[C@@]2([C@@H1]3CCCO3)CCCO2 CN1C=CC(C(=O)N2CCOC[C@@H1](NC(=O)C=3SC=NC=3Cl)C2)=C1 C[C@@H1]1C[C@@H1](CNC(=O)CN(C)C)CN(C(=O)C2=N[NH1]C3=C2NCCC3)C1 CC(C)(C#N)CCC(=O)N1C[C@H1]2C[C@@]2(NC(=O)C3=COC4=C3COC4)C1 CC1=CC(C)=C([C@H1](C(=O)NCC2=CC=C(F)C=C2)N(C)[C@@H1](C)CS(C)(=O)=O)C=N1 CN(CCNS(=O)(=O)C1=CC=C(F)C=C1)C(=O)NCC2=CSC(C3=CC=CO3)=N2 C#CC1=CC=C(C(=O)N2CCC[C@@H1](C(=O)N[C@H1]3CCOC3)CC2)C=C1 COC(=O)[C@@H1]1CN(C(=O)C(O)CSC)C[C@H1]1CNC(=O)OC(C)(C)C CC1=C(C(=O)NC[C@H1](O)CC(=O)N2C[C@H1](O)C3(CCCC3)C2)N=CN1C CN(C)CC(C)(C)C(=O)NC1C[C@H1]2CN(C(=O)C(F)(F)C3=CN=CC=N3)C[C@@H1]2C1 C[C@]1(C(=O)N[C@H1]2[C@@H1]3CN(CC4=C(F)C=CC=C4F)C[C@@H1]32)C[C@@]1(F)Cl CO[C@@H1]1C[C@@]2(C(=O)N[C@@H1](C)[C@@H1](C)NC(=O)C3=CN=C(C4=CC=CS4)O3)C[C@@H1]12 COC1=CC=C(C(=O)N[C@H1]2CC[C@@H1](O)CN(C(=O)[C@@H1](F)C(C)(C)O)C2)C(Cl)=N1 C[C@@H1](NC(N)=O)C(=O)N1CC[C@H1](O)C[C@@H1]1C(=O)NCCC2=CC=CC(F)=C2 CCC1=C[NH1]N=C1C(=O)NC2(CCCC(=O)N[C@@H1](C)C3=NC=CC=C3F)CCC2 CCCOCC(=O)N1C[C@H1](CNC(=O)C2=CN=C3C(=C2)OCCN3)C4(CCC4)C1 CC=1C=C(CCC(=O)NC[C@@]2(C)CCCN(C3=CC(Cl)=NC(C4CCC4)=N3)C2)ON=1 CC1=CC=NC(C(=O)NC[C@@H1]2CCCN(S(=O)(=O)CCCCCl)CC2)=C1 C=C1C[C@@H1]1C(=O)NC[C@@]2(OC)CCN(C(=O)C3=CC=C(OC)C(C)=C3)C2 CC(C)SC1=CC=C(C(=O)N2CCN(C(=O)C3(C#N)CCC3)C[C@H1](O)C2)C=C1 C=CCCN1C=C(C(=O)N2[C@H1]3CC[C@@H1]2C[C@@H1](NC(=O)C(C)(C)C(C)(F)F)C3)N=N1 CO[C@H1](C)CCC(=O)NC1(C2(O)CCN(C(=O)C3=CN=CC(Cl)=C3)CC2)CC1 C=CCC(C)(C)C(=O)N[C@H1]1C[C@H1]1CNC(=O)C2=CC(C3=CC=CC=C3)=CC=C2N CSC1=NC2=NC=NC(N3CCOC[C@@H1](CNC(=O)C4(CO)CC4)C3)=C2S1 CON(CCO)C(=O)C[C@H1]1CCCC1(F)F CN(C[C@H1]1CCCCN1C(=O)COCP(C)(C)=O)C(=O)[C@H1]2CCC3=C[NH1]N=C32 C[C@@H1]1C[C@@H1](C(=O)NCCC2(C)OCCO2)CN(C(=O)CC3(O)CCCC3)C1 CCCCC(=O)N[C@@H1]1C[C@H1]2CC[C@H1]1N(C(=O)C3=CN=C4C(C=NN4CC)=C3)C2 CC(=O)N1CCCC[C@@H1]1C(=O)N2CC(C3CN(C(=O)C=CC=4C=N[NH1]C=4)C3)C2 NC1=CC(C(=O)N2CCC[C@@H1](CCNC(=O)C3(F)CCOCC3)CC2)=NC=C1Cl C[C@H1](C1CCCC1)N(C)C(=O)[C@@H1]2N(C(=O)COC=3C=CSC=3)CCC2(C)C COC1=CC=C(S(=O)(=O)NC2=CC(NCCN3CCOC3=O)=CC=N2)C=C1OC CCOC(CC(=O)NC1([C@@H1]2CCN(C(=O)[C@@H1]3CCCS3)C2)CC1)OCC CC(C)(C(=O)N1CC[C@@H1](F)[C@@H1](NC(=O)[C@@H1]2CNC(=O)N2)C1)C3=CC=C(F)C=C3F CC(C)C[C@H1](CNC(=O)C1(O)CCC(=O)CC1)NC(=O)C=CC(=O)N(C)C O=C([C@@H1]1CCC2=NC=C(Br)N2C1)N3CC[C@H1](OCCO)C3 CC[C@@H1](CC(=O)NC[C@@]1(F)COCCN(C(=O)C(F)(F)COC)C1)C(F)F CC[C@H1]1CN(C2=NC=C(C)C=C2S(=O)(=O)N3CC[C@@H1](C4CCC(F)(F)CC4)C3)C1 CC[S@@](=O)CC(=O)N1CCCC[C@H1]1C2=N[NH1]C=C2C(=O)N[C@H1]3CC(=O)N(C)C3=O CO[C@@H1]1CN(C(=O)[C@@H1](C(C)C)N2C=NC=N2)C[C@@H1]1NC(=O)C3=CSC(C(F)F)=C3 CC(C)C1=NC(CC(=O)N(C)C[C@H1](C)CNC(=O)C2=CCSC2)=CS1 CCC=1SC=NC=1C(=O)NCCCNC(=O)C2=CC=CC=C2CN3C=NC=N3 CCC1=CN=CC(C(=O)N[C@H1]2CC[C@@H1](CN=C3[NH1]C=NC(Cl)=C3C(=O)OC)C2)=C1 CO[C@@](C)(CO)C(=O)NC[C@]1(F)C[C@H1](CNC(=O)C=2C=CC3=NN=NN3C=2)C1 CN(CC1(NC(=O)C=2C=NSN=2)CC1)C(=O)C3=CC=CC(OCC(F)(F)F)=C3 C[C@H1](C(=O)N[C@H1]1CC12CCN(C(=O)CSC3=CC=CC=C3O)CC2)C4CCCC4 COC(=O)C1=NC(NC(=O)[C@H1]2C[C@@H1]2NC(=O)C3=CC(C)=CC(O)=C3)=C(Br)C=C1Br O=C(C=1SN=NC=1C2CCC2)N3CCC[C@@H1](C4CCN(C(=O)C5(O)CC5)CC4)C3 N#CC1=CN=C(N[C@H1]2CCCCCC2(F)F)C(Br)=C1 CC1=CC=C(C(=O)N[C@]23CCCC[C@H1]2N(C(=O)CCC4=NC=CN4C)CC3)N=N1 CCC1=NC(C(=O)NC[C@H1]2[C@H1](C)CCCN2C(=O)CC3=CC=NO3)=CO1 COC(=O)C(C)(C)CC(=O)N1CC[C@@H1](O)[C@H1](N(C)C(=O)[C@H1]2C[C@H1](O)C2)C1 COC(=O)[C@H1]1COC2(C(=O)NC3[C@H1]4[C@H1]5CC[C@@H1](C5)[C@@H1]34)CC1C2 COC1=CC(C(=O)NC2=NC(Cl)=CC=C2C(=O)N3CCC(O)(CO)CC3)=NN1C CN(C)[C@H1](C(=O)N[C@H1]1C[C@@H1](CNC(=O)CC=2C=C[NH1]C(=N)C=2)C1(C)C)C(C)(C)C C[C@H1](CF)C(=O)N[C@H1]1C[C@@H1](CNC(=O)CCN2CCN(C)CC2)C1 C[C@H1](CNC(=O)C1CC(CF)C1)NC(=O)C[C@@H1]2CC(=O)NC3=CC=CC=C32 O=C(N[C@@H1]1CCCC[C@@]12CCCN(C3=NC(C4CC4)=NS3)C2)C5CC(F)(F)C5 CCCC[C@H1](O)C(=O)N1CCN(C2CN(C(=O)C3=CC=C(S(C)(=O)=O)[NH1]3)C2)CC1 C=C1C[C@@H1](C(=O)NC2=CC(Cl)=CC(Cl)=N2)N(C(=O)C3=CC(Br)=C(O)C(Br)=C3)C1 CC#CCN(C)C(=O)[C@H1](F)C1CC(NC(=O)C(C)(C)[C@H1]2CCOC2)C1 CN(C)C(=O)[C@H1](CO)NC(=O)C1=CC=NC(CNC(=O)C=2C=CON=2)=C1 CC[C@@]1(C)C=C(C(=O)N2CCC[C@@H1]2CNC(=O)C=CC3=CC=C(F)C(C)=C3)C1 COC1=CN=NC(C(=O)N2CC(C)(C)OC[C@@H1]2CNC(=O)[C@@H1](C)C3=CCCC3)=C1 CC(=O)OC[C@@H1](OC(C)=O)C(=O)N1C[C@@H1]2CN(C(=O)C3=CC=CC(Cl)=C3Cl)[C@H1]2C1 COC1=CC(Br)=CC=C1CNC(=O)C2=C(F)C=C(C(F)(F)F)C=C2Br O=C(CCC=1N=C[NH1]N=1)N2CC[C@@]3(C2)CN(C(=O)C4=CC=CC(F)=C4Cl)CCO3 COC=1C=C(C(=O)N[C@](C)(CO)C(=O)NCC=2C=NN(C(C)C)C=2)ON=1 O=C(NC1(CO)CC=CC1)C2=CC3(CN(C(=O)[C@@H1]4C=CCCC4)C3)OC2 CCN1C(=O)CC[C@H1]1C(=O)N(CCNC(=O)CC2=CN=C(C3CC3)[NH1]2)C[C@@H1](C)O COC1=CC=C2C(C(=O)NC[C@H1]3C[C@H1]3CNC(=O)CN4C=NC=C4C)=COC2=C1 CC1(C)C[C@@H1](C(=O)NC[C@@H1](F)CNC(=O)C(C)(C)C2=CN=CN=C2)O1 CN1N=C(C(=O)NC[C@H1]2CCCCN(C(=O)[C@@H1]3[C@H1]4CCC(=O)[C@H1]43)C2)C=C1C(F)F O=C(NC[C@]1(F)C[C@@H1](CNC(=O)C2CCCC2)C1)C3=CC=C(Cl)C=C3F CC[C@]1(C(=O)N[C@@H1]2CCOC[C@H1]2C(=O)N3CC4(CCCCCC4)C3)CCC[C@H1]1O CC[C@H1]1CN(C(=O)C[C@@H1]2CC3(CC3)CO2)CC[C@H1]1CNC(=O)CN4C=NC=N4 CN(C)CC(C)(C)CC(=O)NCCC1CN(C(=O)[C@@H1]2[C@H1]3CC4=CC=CC=C4[C@H1]32)C1 CO[C@H1](C(=O)NCCOCCC(=O)N(CCO)C1CCCCC1)C(C)(C)C CC1=CC=CC=C1C(=O)N[C@@]2(C)CCN(C(=O)C(F)(F)C(F)(F)C(F)F)C2 CCC=1OC=NC=1C(=O)NCCN(C(=O)C2=CC=CC=C2COC)C3CC3 C[C@@H1](C1=CC=CC(C(F)(F)F)=C1)N2CCS(=O)(=O)C[C@H1]2CO CC[C@H1](SC)C(=O)N1CCN(C(=O)C2=CC=CC(P(C)(C)=O)=N2)C[C@H1]1C(C)C CC1(C)OCCO[C@H1]1CC(=O)N[C@H1]2C[C@@H1](O)[C@H1](NC(=O)C3=CN=C(O)C=C3O)C2 CCC(=O)NCC(=O)N1C[C@@H1]2C[C@H1]1C[C@H1]2CNC(=O)[C@@](C)(OC)C(C)C CC1=CN=CC(C(=O)NC[C@H1]2C[C@H1]3C[C@@H1](C2)N(C(=O)C=4C=CSN=4)C3)=C1Cl COC[C@H1](O)CN(C)C(=O)[C@H1](NC(=O)C1=CC(O)=CS1)C2=CC=CO2 CCN1C=CC(C(=O)NC2([C@H1]3CCCN(C(=O)C4=CN=NN4C)C3)CC2)=N1 CN(C(=O)CSC1=NN=NN1C)[C@H1]2CCCN(C(=O)[C@H1]3C=CCC3)C2 COC[C@]1(C(=O)N2CC(C)(NC(=O)C3=CN=C4C(F)=CC=C(F)C4=C3)C2)CCC1 CO[C@@H1](C)CCC(=O)NCC[C@H1]1CCCN1C(=O)C2=CN=C(N)C(O)=C2 CC[C@@H1]1CC[C@H1](C(=O)N2CC[C@]3(NC(=O)C4=CC(Cl)=CC=C4F)C[C@@H1]3C2)O1 C=CC[C@H1](CNC(=O)[C@@H1]1C[C@H1]1C#N)C(=O)N(C)CC2=CN=N[NH1]2 C[C@@H1]1CO[C@H1](C(=O)N2CC[C@@H1](OCCNC(=O)[C@@]3(C#N)C[C@H1]4CC[C@H1]3C4)C2)C1 CC(C)S[C@@H1](C)C(=O)N[C@@H1](C)CCN(C)C(=O)CCC1=NC=CC=N1 CC[C@H1](CCOC)NC(=O)[C@@H1]1C[C@@H1](C)CN1C(=O)[C@@H1](F)CCC(C)(C)C CC(C)(O)C#CC(=O)N1CC[C@@](CO)(C(=O)NC[C@H1]2C[C@@H1]2C3CC3)C1 O=C(NC[C@@H1]1CC2(CC2)CN1C(=O)C[C@H1]3CCCSC3)C4=CN=C(S)[NH1]4 C=CN1N=NC=C1C(=O)NC2([C@H1]3CCCN3C(=O)C(=O)C=4C=NN(C)C=4)CC2 CO[C@H1](F)C(=O)N1CC[C@@H1](O)[C@H1](NC(=O)C2=CC=C(OC(F)F)C=N2)C1 COCCCCC(=O)N[C@@H1]1CCCC[C@H1]1NC(=O)CC=2C=CSN=2 CSC1=CC=C2C=C(C(=O)NCCC[C@H1]3CCCN3C(=O)C=4C=C(C)ON=4)[NH1]C2=C1 CCCCCC[C@@H1](C)CC(=O)N1CCCO[C@H1](CCNC(=O)C2SCCS2)C1 C=C[C@H1](OC)C(=O)N(C)[C@H1](C)CCNC(=O)[C@@H1]1CC[C@H1](C(N)=O)C1 CCC1=CN=CC=C1[C@H1](N[C@H1]2CCO[C@H1]2C)C3=NN=NN3CCC4CC4 CC1=CC=C(CCC(=O)N(C)C2CN(C(=O)CN3C=CC=CC3=O)C2)O1 N[C@@H1]1CCCC1C2N(C=C3N=CC=C4C=CC=NN34)C2 CO[C@H1](C)CC(=O)N[C@H1]1CCN(C(=O)C=2C=C(Br)N(C)C=2)CC[C@@H1]1CO CC#CCNC(=O)CC1(C2CC2)CCN(C(=O)[C@H1]3CC[C@H1]3C(=O)OC)CC1 CC1=CC=CC(F)=C1C(=O)N[C@@H1](C)C[C@@H1](C)NC(=O)C2=C[NH1]C3=C(Cl)C=CC=C23 CC1=NC=C2N1CCN(S(=O)(=O)C=3C=CC(=NC[C@@]4(N(C)C)CCSC4)[NH1]C=3)C2 O=C(NCC1(O)CC(N=C2[NH1]C=NC=3C(C4=CC=CC=C4)=NSC2=3)C1)C5(Cl)CC5 CC=1N=C(CNC(=O)[C@H1](F)N2C=CN=C2)OC=1C(=O)NCC3=CN(C4CC4)N=N3 CC(C)CC(C)(C)C(=O)N(C)CCN(C(=O)[C@@H1](CCO)N(C)C)C(C)C C[C@@H1]1[C@@H1](NC(=O)C2=CC(C(F)(F)F)=NN2C)CCN1C(=O)[C@@H1]3CC3(C)C C[C@@H1]1C[C@H1]1CCC(=O)NCC[C@@H1]2CCN(C(=O)CCNC(=O)C=CCl)C2 CCC=C(F)C(=O)N(C)[C@H1]1[C@@H1]2CN(C(=O)C=CC3=CC=C(C(N)=O)O3)C[C@@H1]21 CCN1C=NN=C1C(=O)N[C@@H1]2CC[C@H1](CNC(=O)[C@@](C)(F)CC3CCCC3)C2 C=CCC1(C(=O)NCC2(O)CC(NC(=O)[C@H1]3C=C(C)CS3)C2)CCCCC1 COCC#CCNC(=O)[C@H1]1CCC2(CC2)N1C(=O)[C@@H1](C)C(F)F CCC1=CC(C)=CC=C1C(=O)NCC(C)(C)CNC(=O)CC2(COC)CC2 CCC(C)(C)N[C@H1](C)C(=O)NCC(C)(C)CN(C)C(=O)[C@H1]1OCCN(C)C1=O CC(C)[C@@H1](CCN(C)C(=O)C1(N(C)C)CC1)NC(=O)C=2SC=CC=2F CN1C(=O)OC[C@H1]1C(=O)NC2CCN(C(=O)C=3C=C(C4CC4)[NH1]N=3)CC2 CS(=O)(=O)C1=CC(C(=O)N[C@@H1]2CC[C@@H1](N3CCN(C(=O)C4(O)CC4)CC3)C2)=CO1 CC=1C=CSC=1CC(=O)NC[C@@]2(C(=O)N3CCC(F)(CF)CC3)CCCO2 CN(CC(C)(C)CNC(=O)C[C@@H1]1CC=CCC1)C(=O)[C@@]2(C)C[C@H1]3CC[C@@H1]2O3 C=CC[C@H1](CNC(=O)C1=CC(Br)=C[NH1]1)NC(=O)C2=CN3C(=N2)C[C@@H1](C)CC3 CO[C@H1](C)CCC(=O)N1CCC[C@@H1](C(=O)NCCCCN2CCC2)C1 COC1=C(Br)C=CC=C1C(=O)N2CC[C@]3(C[C@@H1]3C(=O)N[C@@H1](C)C#N)C2 COC1=CC=C(C)C=C1CN2CCC[C@H1]2C(=O)NCC3=NOC(C4=CC=CC=C4)=N3 CCCCCC(=O)N(CCNC(=O)[C@H1]1COC2=CC=CC=C2C1)C(C)C CN1CC[C@H1](C(=O)NCCC2(O)CN(C(=O)C=3C=C(C4=CC=CO4)ON=3)C2)C1 COCCCCC(=O)N1CCCC[C@H1](CNC(=O)C2=CN=C3C(C=NN3C)=C2)C1 C[C@H1]1[C@H1](NC2=CC=3N=C(O)OC=3C=C2[N+1](=O)[O-1])C4CCN1CC4 CCC(CC)C[C@H1](F)C(=O)N[C@@H1]1CCN(C(=O)COC=2C=CN(C)N=2)C[C@H1](O)C1 C=CCN1C[C@H1](C)N(CC2=CC=CC=C2)C[C@@H1]1C C[C@@H1](CCCCO)NC(=O)C=1OC=CC=1CNC(=O)[C@H1](C)C=2C=NN(C)C=2 CC[C@@]1(NC(=O)C2=C[C@H1](O)CCC2)CCCN(C(=O)CN3CCOCC3)C1 O=C(C[C@H1](O)CNC(=O)C=1C=C(C2CC2)ON=1)NC3=CC(Cl)=CC=C3O CC(=O)NCCCC(=O)N[C@@H1](C)[C@H1](C)C(=O)N(C)CC(=O)OC CC(C)N1N=CC(C(=O)NCCC2(O)CN(C(=O)C3=NN(C)C=C3I)C2)=N1 CCSCCC(=O)NCCCCC(=O)N[C@H1]1CCOCC12CCC2 CC[C@@H1](C)/C=C/C(=O)N1CC2(CC[C@@H1]2CNC(=O)CC=3N=C(C)SC=3Cl)C1 CC=1N=C[NH1]C=1CC(=O)NC[C@H1](F)CNC(=O)C2=CC=C3N=C(O)[NH1]C3=C2 C=CC[C@@]1(NC(=O)CC2=CC=C(C)C=C2C)CCCN(C(=O)CO[C@@H1](C)CC)C1 C[C@@H1](CN(C)C)NC(=O)[C@@H1]1CN(CC2=CC=C(OCCCl)C=C2)CC[C@@H1]1O O=C1CCN(C(=O)[C@H1]2CN(CC3=CC4=CC(Cl)=CC=C4[NH1]3)CCO2)CCN1 CCN1CCC[C@@H1]1C(=O)NCCOC2CCN(C(=O)[C@@H1]3COC4=CC=CC=C43)C2 CC=1C=C(F)SC=1C(=O)N2CCC[C@@H1](C3(NC(=O)C[C@H1]4CCC(=O)NC4)CC3)C2 CC(=O)NCCCCC(=O)NC[C@@H1]1CCN(C(=O)C=2OC(C)=CC=2C)C13CCC3 C[C@@H1]1CCN(C(=O)C[C@H1]2CCCCO2)[C@H1](CNC(=O)C3=CN=C(C(N)=O)S3)C1 CONC(=O)C1CCN(C(=O)CCN2CCC[C@H1](C=3C=CN(C)N=3)C2)CC1 CC1(C)CC[C@@H1](C(=O)NC[C@H1]2CN(C(=O)C3CC=CC3)CCO2)C1 N#CCC(=O)N1C[C@H1]2C[C@H1]1C[C@@H1]2N3CCC(OC4=CN=CC(Cl)=N4)CC3 CC1CC(C(=O)N[C@H1]2C[C@H1](F)CN(C(=O)C3=CC(O)=NC4=CC=C(F)C=C34)C2)C1 C[C@@H1](NC(=O)C[C@@H1]1C=CCC1)C(=O)N2CC(NC(=O)[C@@H1]3CC4=CC=CC=C4S3)C2 CN1CCOC[C@@H1]1C(=O)NC[C@H1]2CCCN2C3=NN=C(C=4C=CON=4)S3 O=C(N[C@H1]1CCCC12CN(C(=O)C=C(Cl)Cl)C2)[C@@H1](O)C3=CC=C(Cl)C=C3F COCO[C@@H1](C)C(=O)N[C@@H1](CCN(C)C(=O)C1=NC=NC(C)=C1C)C(C)C COCCO[C@H1](C)C(=O)N1C[C@@H1](N(C)C(=O)CSCC(F)F)C2(CC2)C1 C[C@H1](NC(=O)CN1CCOCC1=O)[C@@H1]2CN(C(=O)C3(C)CC(C)(C)C3)CCO2 C[C@H1](CN(C)C(=O)NCCC=1C=NN(CC2=CC=CC=C2F)C=1)C(=O)OC(C)(C)C CC1=CC=C(C(=O)N[C@H1]2C[C@H1](C)CN(C(=O)[C@H1]3CC4=NC=CN4C3)C2)C(N)=C1F CC1=NSC(C(=O)N2CCN(C(=O)C3=CC(C4CCCC4)=NO3)CC[C@@H1]2C)=C1N CC1=NC(C)=C(CNC(=O)C2(CNC(=O)[C@H1](F)C(C)C)CC=CC2)S1 CC1=NC(CC(=O)N[C@H1]2C[C@@H1](C)CN(C(=O)C3=CN=CC=4N=C(C)[NH1]C3=4)C2)=N[NH1]1 CC=1N=C(C)N(O)C=1C(=O)NC[C@H1]2C[C@@H1]2CNC(=O)CCC3=CN(C)C=N3 C[C@@H1]1C[C@H1](NC(=O)C2=NOC(C)(C)C2)CN(C(=O)CN3C=NC4=CC=CC=C43)C1 O=C(C=CC1CC1)N[C@H1](CC(F)F)C(=O)N2CCC[C@@H1](CCO)C2 C=CCCCC(=O)N[C@@H1]1CC[C@@H1](CNC(=O)C2=CC3=C(C([N+1](=O)[O-1])=C2)OCO3)C1 CS[C@H1](C)CCC(=O)N1CC[C@H1](C2(NC(=O)CCCC(C)C)CC2)C1 CCCN(C(=O)C1=CC=CS1)[C@@H1]2CCN(C(=O)C=3C=NN([C@H1](C)CC)C=3C)C2 CC[C@@H1](CNC(=O)[C@@H1]1CCC[C@H1]1C)NC(=O)C2=NC=C(C)C=C2OC C=CCN1C=CN=C1C(=O)N(C)[C@@H1]2CCCN(C(=O)C=C(C)C3=CC=CO3)CC2 C#CCC(C)(C)C(=O)NC[C@H1]1[C@@H1](C)CCN1C(=O)C=CC(=O)N2CCOCC2 CC1=NC(Cl)=CC=C1CC(=O)NCC=C2CCN(C(=O)C=CCO)CC2 CCN(C(=O)C1=CC(SCC)=CN=C1O)[C@H1](C)CNC(=O)C(=O)NC(C)C CCC1=NN(C)C(Cl)=C1CN(C)CCOC2=CC=CC(I)=C2 CC(C)C[C@@H1](CNC(=O)[C@@H1]1OCCN(C)C1=O)NC(=O)[C@@H1]2[C@H1]3CC(=O)C[C@H1]32 CC[C@@H1]1C[C@H1](C(=O)NCCCC[C@H1](C)NC(=O)C2=CC(C)=CC(Cl)=C2C)CCO1 C=CCC1(NC(=O)C2=CC(F)=CC(C(C)C)=C2)CN(C3=NN=C(COC)S3)C1 COC(=O)NCCC(=O)N1CCCC[C@H1](N(C)C(=O)CC=2C=CSN=2)C1 COC[C@]1(C(=O)N[C@H1]2C[C@@H1](OCC(=O)NCC3CCCC3)C2)CCCO1 C#CC[C@](C)(CC)C(=O)N1C[C@@H1](C)[C@@H1](NC(=O)C=C2CCN(C)CC2)C1 CC=1C=C(CN(C)C(=O)CN(C(=O)[C@H1](O)CN(C)C2)CCC(C#N)CC2)ON=1 CCN(CCN1C=C(C=CC(C)=O)N=N1)C(=O)[C@H1]2C[C@](O)(CCC(C)(C)C)C2 C[C@H1](C(=O)NC12CC(C(=O)NC[C@H1]3C=CCOC3)(C1)C2)N4CCOC4=O CN=C1[NH1]C=C(C(=O)N2CC[C@@]3(CCCC[C@@H1]3NC(=O)CC4=NN=CN4C)C2)S1 O=C(N[C@@H1]1[C@H1]2CCN(C(=O)[C@@H1]3CCSC3)[C@H1]21)C4=CC=C(N5CCCCC5=O)C=C4 C#CCN1CC(OCC2CCN(C(=O)[C@H1](C)N3C(=O)CCC3=O)CC2)C1 C=CCCCC(=O)NCC1(CN(C)C(=O)C(F)(F)C=C)CC1 CCC1=CON=C1CC(=O)NC[C@@H1]2CCCCN2C(=O)[C@@H1](CC(F)F)C3CCC3 CN1C=C(C(=O)CCC(=O)N[C@@H1]2CC[C@H1](NC(=O)[C@@H1]3CCC3(C)C)C2)C=N1 CC(C)C[C@@H1](O)[C@H1](C)C(=O)NCCCOCCC(=O)NC1=CC=C(O)C(=O)C=C1 CC=1C=C2C(C(=O)N[C@H1](C)[C@H1](NC(=O)C3=CC(Br)=NO3)C(C)C)=NC=CN2N=1 CC[C@@H1](CN(C)C(=O)[C@@H1](C)P(C)(C)=O)NC(=O)C=1C=NN(C(C)C)C=1C CC[C@H1](O)C(F)(F)C(=O)NCCN1CCC(NC(=O)C2=CC=CC(SC)=N2)CC1 CC1=C(C#N)C=CC=C1C(=O)NC[C@](C)(NC(=O)[C@H1]2OCCCC2(C)C)C(C)C CCCC[C@@H1](CC)C(=O)NC[C@H1]1C[C@@H1](C(=O)N[C@H1](CCC)C(=O)NC)CO1 C=CCOCC(=O)NC[C@H1](C)CN(C)C(=O)[C@H1](C1=CC=C(Cl)C=C1)C(C)C O=C(NC1(C2(O)CCN(C(=O)C3(Br)CC3)CC2)CCC1)C4=CN=C(S)[NH1]4 CCN(C)C(=O)C[C@@H1]1CCCCN1C(=O)CCC2=CC=CC=N2 CC1=NC(C(=O)N(C)C2CCC(NC(=O)C3=CC=NN3CC#N)CC2)=C(C)N1C CC(C)C[C@@](C)(CNC(=O)CSCCC(F)(F)F)NC(=O)[C@H1]1CC2(CC2)CO1 COCC(=O)N[C@@H1](C)C(=O)N1CCN(C(=O)[C@@H1](C)CC(=O)OC)C2(CC2)C1 C=CC[C@@]1(NC(=O)CSC)CCN(C(=O)[C@H1](CCC2=CC=CC=C2)C(C)(C)C)C1 CC(C)[C@H1](N=[N+1]=[N-1])C(=O)NC[C@H1](O)CNC(=O)[C@@H1]1OCCC1(C)C COC1=CC=NC(C(=O)NC[C@H1](NC(=O)[C@H1](C#N)C(C)(C)C)C(C)C)=C1O C[C@@H1](CNC(=O)[C@@H1](C)[C@@H1]1CCOC1)NC(=O)C2=CN(C)C(C(F)F)=N2 O=C(NC1CN(C(=O)[C@@H1]2CSCN2C(=O)C3CCC3)C1)[C@H1]4CCC5=NC=NN5C4 COC(=O)[C@H1]1CN(C(=O)[C@H1]2CC3(CC3)CN2C(=O)C=4SC=CC=4OC)CC[C@@H1]1O CC1=CC=C(CC(=O)N2C[C@H1](O)[C@H1](NC(=O)[C@@]34C[C@@H1]3COC4(C)C)C2)S1 CC[C@@H1](CNC(=O)CCC1=CC(F)=CC(Br)=C1)NC(=O)C[C@@H1]2CCN(C)C2 O=C(C=CC1=CC=CS1)C(=O)N(CCCNC(=O)CC2CSC2)C3CCCC3 C[C@@H1]1OC2(C)CC1(C(=O)N[C@H1]3CCN(C(=O)CN4CC(=O)NC4=O)[C@H1]3C)C2 CCO[C@H1](C(=O)N1C[C@H1]2C[C@@]2(CNC(=O)[C@H1]3C[C@@H1](O)C3)C1)C4CC(F)(F)C4 CCCC(C)(C)CC(=O)N[C@H1](C)CCCNC(=O)[C@@H1](C)OCCC(C)C C[C@H1](NC(=O)C1=CC=C(CNC(=O)C2CC(OC3CC3)C2)C=C1)[C@@H1](O)C(F)F FC1=CC=CC(Br)=C1CN2CC3(CCN3C4=NC=NS4)C2 CC1=CC(CNC(=O)[C@H1]2COCC[C@H1]2NC(=O)CCC3(C#N)CCC3)=NC=N1 CCC1=NOC(COCC(=O)N2CC[C@H1]3CN(C(=O)C[C@H1](C)O)C[C@H1]32)=N1 CC1(C)C[C@H1]1CC(=O)N2CC(C3CN(C(=O)C[C@@H1]4CCC(=O)NC4=O)C3)C2 CCC[C@H1](F)C(=O)N(C)[C@@H1]1CN(C(=O)C2=CC(O)=CC(Cl)=C2)C[C@H1]1O C=C1[C@H1]2C[C@@](NCC(=O)N[C@H1](C)C3=CC=CC(C)=C3)(C2)C1 CS[C@H1]1C[C@H1](C(=O)N2C[C@@H1](F)C[C@H1](NC(=O)COC3=CC=C(C)C(C)=C3)C2)C1 C=C1CC(CNC(=O)[C@H1](C)CC(C)C)(C(=O)NC2([C@H1]3CCCO3)CC2)C1 CN(C)[C@H1]1C[C@@H1](C(=O)N[C@@H1]2C[C@H1](C(=O)N[C@H1]3CCCCC[C@H1]3F)C2(C)C)C1 C[C@H1]1CN(C(=O)C2=C[NH1]C(C(C)(C)C)=C2)CC[C@H1]1NC(=O)C3=CSC(C(N)=O)=N3 CN(CC=1N=CN(C)N=1)C2=NC(=NCC3CC(F)C3)[NH1]C4=C2CSC4 CN(C(=O)C1=NC=C(F)C=N1)[C@@](C)(C(=O)NC=2C=NN(C)C=2)C3CC3 C=CC[C@@H1](CNC(=O)C1=CC(C(C)(F)F)=N[NH1]1)NC(=O)C2=CC(C)=NN2C3CC3 C=CC=C(C)C(=O)N(C1CC1)[C@H1](C)C(=O)NC=2C(C)=NN(CC)C=2C CNC(=O)COCC(=O)N1CC[C@@H1](C)[C@@H1](CNC(=O)C2=CC(C)=CN=C2OC)C1 COC(=O)C=1SC(N2CCC[C@@]2(C)CNC(=O)[C@@H1](CO)C3=CC=CC=C3)=NC=1Cl CCC1(C(=O)N2CC(=O)NC[C@@H1]2C(=O)NOC[C@H1]3CCOC3)CCCCC1 CC1=NC=C(C(=O)N[C@@H1]2C[C@H1]2CNC(=O)C3=CC=CC4=NN(C)C=C34)[NH1]1 C#CCOCCC(=O)NCC1(O)CC(CNC(=O)C2=CON=C2C3CCC3)C1 CCNC(=O)[C@H1](C1=CC(Cl)=CC(Cl)=C1Cl)N2CCC(NS(=O)(=O)C3CC3)CC2 C1=COC(CC2CCN(NCCC=3[NH1]N=C(I)C=3)CC2)=N1 CC=1C=C(CC(=O)N[C@@H1]2CCCN(C(=O)CN3CCC[C@H1]3CO)[C@H1]2C)ON=1 COCCCCC(=O)N[C@H1]1CCC[C@H1]1NC(=O)C2=NC=C(C#N)C=C2Cl CSC1=NC(N2CC=C[C@@H1](NC(=O)[C@@H1]3CCCN3C(C)C)C2)=NC=C1C CC(C)N(CCN(C)C(=O)[C@]CCF)C(=O)[C@H1](C)N1C=CC=N1 NC(=O)C1=CC=CC(C(=O)N2C[C@H1](O)[C@H1](NC(=O)CCC3=CC(Cl)=NO3)C2)=C1F C=C[C@@](C)(CC)C(=O)N1CCC(C)(CNC(=O)[C@]2(C)COC3=CC=CC=C32)CC1 C=CCOC(=O)NCC(=O)N[C@H1]1CC[C@H1](NC(=O)CN2C[C@H1]3C[C@@H1]3C2)C1 C[C@H1](CCNC(=O)C(C)(C)C1CCC1)N(C)C(=O)C[C@@H1]2CCC[C@H1](C3CC3)O2 O=C1CCCC[C@@H1](C(=O)NCCCCCCN=C2[NH1]C=C([N+1](=O)[O-1])C=N2)N1 CN(C[C@H1]1COCCN1C(=O)[C@H1]2CCCN2N=O)C(=O)C3=CSC(Cl)=N3 CC(=O)N(C)CCC(=O)N1CCC[C@@](C)(CNC(=O)C(F)(F)[C@@H1](O)C2CC2)C1 CCCN(C(=O)C[C@H1]1CCCN1C)C2CCN(C(=O)[C@@H1]3CC(C(C)C)=NO3)CC2 CCO[C@H1](C)C(=O)NCC1(COC)CCN(C(=O)CCC#N)CC1 CC1(CNC(=O)C2(F)CC2)CCN(C(=O)C3=CC=CC4=NC=CN=C34)CC1 C[C@@H1]1C(=O)N2CCC[C@@H1]2CN1C(=O)[C@@H1]3CCCN([C@H1](C(=O)O)C(F)(F)F)CC3 CC1=CSC(C(=O)NCCC2(CNC(=O)C#CC(C)C)CC2)=C1C CCNC(=O)[C@@H1](C1=CC=NC=C1Br)N2CC(F)(F)C[C@H1]2CC#N CCC1=NC(CC(=O)NC[C@H1]2CCN(C(=O)C3CC(=O)C3)CC2(F)F)=CS1 CC=1C=CN([C@H1](C)C(=O)N[C@@H1]2C[C@H1]2CNC(=O)C=3C=CC4=NN(C)C=C4C=3)N=1 CC1=CSC(CC(=O)NC[C@]2(O)CCCN(C(=O)C[C@@H1]3CCOC3)C2)=C1 CC(=O)C(=O)N1CCC2(CC1)CN(C(=O)COC3=CC=C(F)C(C)=C3)CCO2 C[C@@H1](C1CCCC1)N(C)C2=NC3=C(C(N4CCC(C(F)F)CC4)=N2)COCC3 CON(C)C(=O)C1CC2(CC(NC(=O)C[C@@H1](C)CN(C)C)C2)C1 C=C1C[C@H1]1C(=O)NC[C@]2(C)COCCN(C(=O)C(=O)NCCOC)C2 C#C[C@H1](COC)NC(=NCCOC(C)(C)CC)NC(CC)CC COCC1=CC(C(=O)NC[C@@H1]2CC[C@H1]2NC(=O)CCCCCSC)=CS1 O=C(NC1CCN(C(=O)C[C@@H1]2C=CS(=O)(=O)C2)CC1)[C@@H1]3CC34CC4 C[C@@]1(CNC(=O)[C@]2(C(F)F)CCCO2)CCCN1C(=O)C3=CC=CC4=CN=CN34 CC[C@@H1]1CCC[C@@H1]1C(=O)N2CC(C3CCN(C(=O)C4CC5(C4)CC5(F)F)CC3)C2 CCC=1C=CSC=1C(=O)N2C[C@H1]3C[C@H1]2CN(C(=O)CC4(C)OCCO4)C3 C[C@@H1](C(=O)N1CCCC[C@H1](CNC(=O)C2=CC(Cl)=CC=C2C(F)F)C1)S(N)(=O)=O O=C(N[C@H1]1CCCO[C@H1]1C2CCN(C(=O)C3=CC(O)=NC(O)=N3)CC2)[C@@H1]4C[C@@H1]4F CN1C=C(C#N)C=C1C(=O)NC[C@H1]2CC[C@H1](NC(=O)CC34CC(C3)C4)CC2 CC1(C)CN(C2=NC=CC(CC#N)=N2)C[C@H1](CNC(=O)C3=CC(C#N)=C[NH1]3)O1 C[C@H1]1C[C@@]1(NC(=O)[C@H1]2CN(C)CCN2C)C(=O)NC[C@@]3(C)CCN(C)C3 CN1C=CC(CCC(=O)N2C[C@@]3(C(=O)NCC4(F)CC(O)C4)C[C@H1]2CCO3)=C1 CC=1[NH1]C2=CC=CC=C2C=1CC(=O)NC3=CC=CC(Br)=C3CN CCSC1=CC=CC=C1CC(=O)N2C[C@H1](NC(=O)C[C@@H1]3C=NN(C)C3=O)C[C@@H1]2C CC1=CN=CC(CC(=O)N[C@H1]2C[C@H1](NC(=O)C34CC(CO3)C4)C25CCC5)=C1 C=CC[C@@H1](CC)C(=O)NC[C@H1]1CCN(C(=O)C2=CN=C(O)C([N+1](=O)[O-1])=C2)C13CC3 CN(CCNC(=O)C1C[C@@H1]2CCC[C@H1](C1)C2(F)F)C(=O)CN3CCSCC3 CC=1N=NSC=1C(=O)N2CCN(C(=O)[C@@H1]3CC[C@H1](C#N)C3)C[C@@H1]2C4=NC=CN4C CC[C@@H1](C(=O)NCC1(O)CC(CNC(=O)C=2C=C[NH1]C=2C)C1)C3CCC(C)CC3 C[C@@H1](C(=O)N1CCN(CCO)CC1)N2C=C(C3=CN=CC=C3C(F)(F)F)N=N2 C[C@@H1]1C[C@H1](NC(=O)C2(CCN(C)C)CC2)CN1C(=O)C3=CC=CC(C#CCO)=C3 O=C(C=CCF)NC1(C2CN(C(=O)C3=CC=C(OC4CCC4)C=C3)C2)CC1 COC1CCC(C)(C(=O)N(C)[C@@H1](CN=C2C=C(Cl)N=C(C(C)C)[NH1]2)C3CC3)CC1 COCCOCCN(C)CCC(=O)N[C@H1]1C[C@@H1]1NC(=O)[C@H1]2CCS(=O)(=O)N2 CN(CCOCCNC(=O)CCCC(N)=O)C(=O)C1=CC=C2N=CSC2=C1 C[C@H1]1C[C@H1](CCNC(=O)C(C)(C)C(N)=O)CCN1C(=O)CCC2=NC=C(F)C=N2 C[C@@H1](CCCNC(=O)C#CC1CCCC1)NC(=O)C2=CC=CC=3OC(=N)[NH1]C2=3 O=C(CC1=CC=C(Cl)C([N+1](=O)[O-1])=C1)N[C@H1]2C[C@@H1]3C[C@H1]2N(C(=O)[C@@H1]4[C@H1]5COC[C@H1]54)C3 C[C@H1](C#N)CNC(=O)/C=C/C1CCN(C(=O)CC[C@@H1](C)CN(C)C)CC1 CC1(C(=O)N2C[C@@H1](CO)C3(CCN(C(=O)C(C)(C)CC#N)CC3)C2)CCCC1 COCC1(CNC(=O)C[C@H1](C)OC)CN(C(=O)C2=CN=CC(C(F)(F)F)=N2)C1 N#CC1(C(=O)NC[C@H1]2CC[C@H1](NC(=O)C3=NC(C4CC4)=CS3)CC2)CC=CC1 O=C(C1=CC(F)=CC(I)=C1)N2C[C@@H1]3[C@@H1](C2)N3C(=O)C4=NC=CC=C4Cl CC1(C)CCC[C@H1]1NC(=O)N(CCO)[C@@H1]2C[C@H1]3CC[C@H1]2C3 CC(C)(CCl)C(=O)NC[C@@H1]1CN(C(=O)C2=CC3=CC=C(O)C=C3O2)CCO1 CN1N=CC(C(=O)N[C@H1]2C[C@@H1]3CC[C@H1](C2)N3C(=O)C4=CC=C(C(F)F)O4)=N1 CC1=CC(C(=O)N2CCC[C@@H1](N(C)C(=O)CCSC3=CC=CC=C3)C2)=NC(C)=N1 CC(C)(C(=O)NC[C@H1]1CCC2(CCC2)[C@@H1]1NC(=O)C=C(Cl)Cl)C3=CN=CO3 CC(C)CS(=O)(=O)CCC(=O)NC[C@H1]1C[C@H1]1CNC(=O)C2=CC=NN2C3CCC3 CCC(F)(F)CC(=O)N1CC[C@]2(CC[C@H1](NC(=O)CN3CCSCC3)C2)C1 CCOC1=CC(Br)=CC(CNC23CC(C(=O)NCC=4C=CN(C)N=4)(C2)C3)=C1 CCC[C@@H1]1CCCN(C2=NC(N3CCOC4(CCSCC4)C3)=C5N=CSC5=N2)C1 CC(=O)C1=CC=CC(NC(=O)[C@@H1](C)N(C)CCOC(C)C)=C1O COC(=O)C1CC(N(C)C(=O)[C@H1](C)CN(C)C(=O)[C@@H1]2C[C@@H1](F)C(=O)N2)C1 COC[C@@H1]1CCN(C(=O)C(=O)N[C@@H1](C2=CC=CC=C2C)C3=CC=CC=C3C)C1 O=C(NCCCSC(F)F)[C@H1](C[C@H1]1COCCO1)C(F)(F)F NC(=O)NC1CCC(C(=O)N[C@H1]2C[C@H1](F)CN(C(=O)C=CC3=CN=C[NH1]3)C2)CC1 C[C@H1](C(=O)N1C[C@@]2CC[C@@H1](CN(C(=O)C3CC(C4CC4)C3)C2)C1)N5CCOC5=O CN(C(=O)[C@@H1]1CSCCN1C(=O)C[C@H1]2CCCC(=O)C2)C3CC(C)(C)C3 O=C(N[C@H1]1CN(C(=O)C2=CC=NC=C2O)CCC13CCC3)[C@H1](O)CC4=CN=C[NH1]4 CC1=NC(=NC(=O)C2=CN=C(Br)C(C#N)=C2)C3=CC=CN3[NH1]1 CSC1=CC=C(C(=O)NC[C@]2(C)CCC[C@H1]2NC(=O)[C@@H1]3CC34CCCCC4)O1 O=C1CS(=O)(=O)C[C@@H1](C(=O)NC2(C3CN(C(=O)C4CC(F)(F)C4)C3)CC2)N1 CO[C@H1]1C[C@@H1](CCNC(=O)N(CC=2N=CON=2)C3CC3)C1 CCC1=NC=C(CN=C(N[C@H1](C)COC)N2CC[C@H1](N3C=C(Cl)C=N3)C2)S1 CC=1C=C(CCNC(=O)[C@@H1](N2C=C(C3=N[NH1]C(C)=C3C)N=N2)C(C)C)CON=1 C#CC1(N(C)C(=O)[C@H1](C)CNC(=O)[C@H1]2CCCC[C@@H1]2O)CC1 COC1=CC=CC=C1C[C@@H1](C)N2C=CN=C2C3=CN=C4C=CC=CN34 CC(=O)N(C)[C@H1](C)C(=O)N1CCC(CCNC(=O)[C@H1]2CCOCC2(C)C)CC1 COC1=CC=C(C(=O)N(C)C2CC(NC(=O)[C@H1]3CC(=O)OC3(C)C)C2)C(O)=C1 CC1=NC=C(C(=O)N2[C@H1]3CC=C(C(=O)N4CC[C@H1](O)[C@@H1]4C)[C@H1]2CC3)O1 CSCC(=O)N1CC[C@H1]1C(=O)NC2=CC(C)=CC(CN(C)C)=C2 C[C@@]1(CNC(=O)C23CSC(C2)C3)CCCN1C(=O)C4=CC(=O)C5=CC=CC=C5[NH1]4 COC1=CC=CC=C1NC(=O)[C@H1](C=2C=NN(C)C=2Cl)N3CCS[C@@H1]4COCC[C@H1]43 CC(C)CC[C@@H1](F)C(=O)N1[C@H1](C(=O)N2CC([N+1](=O)[O-1])C2)CC[C@H1]1C(C)C C[C@H1](CC(=O)NC1CC2(CCC(NC(=O)C3(S(N)(=O)=O)CCC3)CC2)C1)C(F)F CCC1=C(C)C=CC=C1C(=O)N(C)CCOCCNC(=O)[C@H1](SC)C2=CC=CS2 CC[C@H1](C)N(C)C(=O)N[C@@H1]1C2=CC=CC=C2C[C@@H1]1CC3=CC=CC=C3 C1C=C(C(=O)N[C@H1]2[C@@H1]3CN(C(=O)C4=CC=C(N(C)C)C=C4C)C[C@@H1]32)C=CN1C CC=1[NH1]N=C(C(=O)N2CC[C@@H1]2C(=O)N[C@H1]3CN(C)C(=O)C34CC4)C=1C O=C(N[C@@]12CC[C@@H1](C[C@H1]1NC(=O)C3=CC4=CC=CC(F)=C4S3)C2)C5=CSN=N5 N#CC1=CC=C(S(=O)(=O)N[C@H1]2CCC3=CC=C(C(=O)O)C=C32)C=C1Cl CC(C)(O)C1=CN=C(CN=C2C=CN=C(N[C@@H1]3CCN4CCCC[C@@H1]34)[NH1]2)S1 CC(=CC(=O)N[C@]1(C(=O)N2CCC[C@H1](N3CCC3)C2)CCC[C@H1]1C)C(F)F C=CCC1(NC(=O)[C@H1]2CS(=O)(=O)CC(=O)N2)CN(C(=O)C3=CC=NC(C)=N3)C1 CCC[C@@H1](C(=O)NC[C@H1](O)CN(C)C(=O)CCC1=CC2=CC=CC=C2O1)N(C)C C#CC[C@H1](NC(=O)[C@H1]1CN(C(=O)[C@@H1](C)CN2C=CC(C)=N2)C[C@@H1]1C3CC3)C(N)=O CC1=CC=C(C(=O)N=C2[NH1][NH1]C3=C2CN(CC4=CC=NC=C4[N+1](=O)[O-1])C3)C=C1C CC(=C(F)C(=O)N1CC[C@H1](NC(=O)C2=NC=CN=C2C)[C@H1]1C(C)C)C3CC3 CC(C)CSCCNC(=O)C=1C=COC=1CNC(=O)[C@@H1](C)N2CCOCC2 CC1=CN(C)[NH1]C1=NC(=O)N2CCN(C(C)=O)C[C@H1]2C O=C(N[C@@]1(CO)CCN(C(=O)C2=CSC(Cl)=C2)C1)C3=CC=C(NCCO)C=C3 CCN1C=C(C(=O)NC(C)(C)CC(=O)N[C@@H1](C)[C@H1](C)F)C=N1 C#CC1=CC=C(C(=O)N(C)[C@@H1]2CN(C(=O)C3(CC(F)(F)F)CC3)CC2(C)C)C=C1 CC1(C)CCC[C@](O)(C(=O)N[C@@H1]2C[C@H1]2CNC(=O)C3=CC=CC=4OC(O)=NC3=4)C1 CN(C(=O)CCC1=NC=C[NH1]1)[C@H1]2CC[C@@H1](NC(=O)[C@@H1]3CC[C@H1]4[C@H1]3C4(F)F)CC2 CC=1C=C(C2(C(=O)N[C@@H1](C)[C@@H1]3CCN(C(=O)C4=C(Cl)CC4)C3)CCC2)ON=1 C[C@@H1](CCNC(=O)[C@]1(C)CCOC1)N(C)C(=O)C2=CC=3C=CSC=3C(O)=N2 CC1(NC(=O)[C@@H1]2CCCC2(F)F)CN(C(=O)[C@H1]3CC(C4=CC=CC(F)=C4)=NO3)C1 CC[C@@H1](NC(C)=O)C(=O)N1CC[C@]1(C)C(=O)NC2=CC(OC)=NC(OC)=C2 CCC1=C(NC(=O)C=2OC(CNC(=O)[C@@H1](C)[C@H1](O)C(C)C)=NC=2C)C=NN1CC COC[C@](C)(OC)C(=O)N1C[C@H1]2[C@H1](CNC(=O)CC=3C=CSN=3)C[C@H1]2C1 C=C(C)CC(=O)NC[C@@]1(C(F)F)CCN(C(=O)C2=NN=C3N2CCCC3)C1 CC(C)N1C[C@@H1](C)[C@@H1](NC(=O)[C@H1]2C[C@@H1](CNC(=O)C(C)(C)C(C)(F)F)C2)C1 CC1=NOC2(C1)CC(C(=O)N(C)C[C@H1](C)NC(=O)[C@H1](C)OCCN(C)C)C2 C=C(C)C1=CC=CC(NC(=O)[C@H1]2CCO[C@H1]2CNC(=O)CN3C(C)=CC=C3C)=C1 C[C@H1](NC(=O)N=C1C=CN(C)[NH1]1)[C@@H1]2CCN(CC3=CC=CC=C3)C2 COCCOCCC(=O)N1C[C@H1]2[C@H1](NC(=O)CCC(F)(F)C(F)F)[C@H1]2C1 COCC[C@@H1](OC)C(=O)N[C@H1](CC(=O)NC[C@H1](CC1CC1)OC)[C@@H1](C)OC CC[C@H1](C)NC(=O)[C@@H1](C1=C(C)CCCC1(C)C)N2CC[C@H1](CC3CCC3)C2 CCCCCOCC(=O)N1C[C@@]2(NC(=O)C3=CC=C(C(C)=O)C(C)=C3)CC[C@H1]1C2 CC(C)[C@H1](CCN(C)C(=O)C=1SC(F)=CC=1Br)NC(=O)C2=CC=CC(N)=C2 CN(CCNC(=O)[C@@H1]1CCCN1C2CCCC2)C(=O)[C@H1]3CCC34CCC4 CC(C)CN(CC(C)(C)C)C(=O)CCOCCN(C)C(=O)[C@H1]1CCCCN1C CN(CC1=NC=CC=C1Br)[C@H1]2CCCN(C(=O)C3=CC=C(F)C=N3)C2 CC=1OC=NC=1C(=O)N2CCN(CC3=CC(O)=CC(Cl)=C3)CC24CC4 CC1=NSC(Br)=C1C(=O)N2CCN(C(=O)[C@]3(O)CCOC3)[C@@H1](C)C2 C=CC(C)(C)C(=O)N(C)CC1CN(C(=O)C2=CC(C(C)C)=C(O)C(C=O)=C2)C1 C=C[C@@H1](CC)CC(=O)N(C)[C@@H1](C)CNC(=O)C1=CC=C(OCC(C)C)N=C1 C=C(C)CCONC(=O)[C@@H1](F)CC1CN(C(=O)[C@H1]2CC(=O)N(C)C2)C1 CC(C)(C)OC(=O)N1CC2C=C(CCN2C(=O)C3=CSC(CC(F)(F)F)=N3)C1 O=C(O)C1=CC=CC(CN2CC[C@H1]2C(=O)NCC3=CC=CN=C3Br)=C1 CC1(C)CCC[C@H1]1C(=O)N2CC[C@H1](CCNC(=O)C3=CC(Cl)=NC(C4CC4)=C3)C2 CCO[C@H1]1CC[C@@H1]1C(=O)N2CCC3(CC2)C[C@H1]3C(=O)NCC(C)(C)CC(F)F CC=C(C)C(=O)NCCCN(C(=O)C1=C(CC)OCCS1)C2CCCC2 CCC(=O)NCC(=O)NC[C@H1]1CCN(C(=O)CN2N=CC(Br)=N2)CC1(F)F C=C[C@H1](CC)C(=O)N1CCO[C@H1]([C@H1](C)NC(=O)CC2=CC=NC(F)=C2F)C1 C=C(C)CNC(=O)[C@@H1](C1=CC=C(C2=CC=CC(Br)=C2)O1)N3CCC(=C(F)F)CC3 CC=CCC(=O)N[C@@]12COCC[C@H1]1CN(C(=O)CC(C)(F)F)C2 CC(C)CN(CC(=O)NC[C@H1]1CC[C@H1]1C)C(=O)CCC2=CC=NC=N2 CN1CCC(N2CCC[C@H1]2C(=O)N(C)[C@@H1]3CCN(C(=O)COCC(F)F)C3)CC1 CC[C@@H1](CC1=CN(C2CCN(C(=O)[C@](C)(O)CCN(C)C)CC2)N=N1)C(=O)OC COC1=CC=C2C(=C1)[C@@H1](C(=O)NC[C@H1]3C[C@](F)(CNC(=O)/C(Cl)=C/Cl)C3)CCC2 CCSC1=CC=CC=C1CC(=O)N[C@H1](C)C2=CC(N)=CC(F)=C2 C[C@H1](NC(=O)C[C@H1]1C=CCC1)C(=O)N(C)CCN(C)C(=O)C=2C=C[NH1]N=2 CCCC[C@H1](NC(=O)[C@H1]1CCSC1)C(=O)N[C@H1](CC)C(C)(F)F C[C@@H1]1OCC[C@@H1]1C(=O)NC[C@H1](CO)NC(=O)CC2(O)CC2 CCOC1=N[NH1]C=C1C(=O)NC[C@@H1]2CCCCN2C(=O)[C@H1](C)OC CN(C)CC(=O)NCC(=O)N1CC(N2C[C@@H1](NC(=O)C3=CN=NN3C)CC2=O)C1 COCCC(=O)NC[C@@H1](C)C(=O)NC[C@@](C)(O)C(F)F C=C(Cl)C(C)(C)C(=O)N[C@@H1]1CCCCC[C@H1]1NC(=O)C2=CN3C=C(Cl)C=NC3=N2 CC[C@H1](CNC(=O)[C@H1]1CCCN(C(=O)C2CCC(=O)CC2)C1)CC(C)C CC[C@@H1](C)[C@@H1]1CCCCN1C(=O)[C@H1]2CC(=O)CN2C(=O)C3=CC(C)=CC(O)=N3 C[C@H1](CCCCNC(=O)CCCSC(C)(C)C)NC(=O)C12CCC(CC1)C2(C)C COCC(=O)N(C)CC(=O)N1CC[C@@H1](NC(=O)[C@H1](C)CC2CC2)C13CCC3 CCOC(C)(C)C(=O)N1C[C@@H1]2C[C@]2(NC(=O)CCC=3C=CSC=3)C1 CCN1N=NC=C1C(=O)N[C@H1](CNC(=O)C2=C(N)C=C(Cl)C=C2Cl)C(C)(C)C COC(=O)C1=CC=CC(NC(=O)[C@H1](C=2SN=CC=2C)N3C[C@H1]4[C@@H1]5CC[C@@H1](O5)[C@H1]4C3)=C1 CCC(=CC(=O)N1C[C@H1]2CN(C(=O)CCC3=CC=CC=C3C#N)C[C@@]2(C)C1C)CC C=C[C@@H1](OC)C(=O)N1C[C@@H1](O)C[C@H1]1C(=O)NCC2=CC=CC=N2 C/C=C/C[C@H1](NC(=O)[C@H1]1CCC2(CC2)C1)C(=O)N[C@H1]3CC=C(C(C)C)CC3 CCN(CC(=O)NCC(=O)N1CCN(C(=O)[C@H1]2CC[C@@H1](N(C)C)CC2)CC1)C3CC3 CCCC(CCC)C(=O)NCC#CCNC(=O)C1=CN(C2=C(F)C=CC=C2F)N=N1 C=C(CCNC(=O)CC=C(Cl)Cl)CNC(=O)[C@@]12CCNC[C@@H1]1C2 CC1=CON=C1CC(=O)N[C@@H1]2CCN(C(=O)C3=CC4=C(N=N3)CCC4)C2 CN(CC=1N=COC=1C(F)F)C(=O)[C@H1](N)C2(O)CCCC2 O=S(=O)(NCCN1CCN(C2=NC=C3SC=CC3=N2)CC1)C4=CC=C(Cl)C=C4F CC(F)(F)C(=O)N1CC[C@@H1](O)[C@H1](C(=O)NC2=CC([N+1](=O)[O-1])=CC=C2F)C1 CC(=O)OCC(=O)N1CCC[C@@H1]1[C@H1](C)NC(=O)CC2=CC=CC(Cl)=C2 C#CCNC(=O)CC(=O)N[C@@H1]1CN(CC2=CC=CC(F)=C2F)CC[C@H1]1C CCN1C[C@@H1](C(=O)N2CCN(C(=O)CCOC3CCC3)CC[C@H1]2C)NC1=O C=CCC(CC=C)C(=O)N1CC[C@H1](N(C)C(=O)C=CC2=NC=C(C)[NH1]2)[C@H1](C)C1 COC[C@@H1](CCO)NC(=O)C1=C(CNC(=O)C2(C(C)(F)F)CC2)N=NN1C CN1C=NC(C=CC(=O)N2C[C@H1]3C[C@H1]2CC[C@H1]3NC(=O)C4=CC(=O)N(C)O4)=C1 C[C@@H1]1CCN(C(=O)C=CCOCC(F)(F)F)CCN1C(=O)C[C@@H1]2CC[C@@H1](O)C2 CC1=NNC(=O)[C@@H1]1CC(=O)N[C@H1]2CCN(C(=O)C3=COC(CO)=C3)[C@@H1]2C(C)C CC1=CC(Cl)=CC(N)=C1C(=O)NCC2(NC(=O)[C@@H1](O)CC(C)(C)C)CC2 CC(C)(C#N)C1=CC=C(NC(=O)[C@@H1]2CO[C@@H1](CO)C2)N=C1 COC1=CC=C(CN2CC(C)(C)CC[C@@H1]2CNC(=O)C3=CCCCO3)N=N1 C#CCNC(=O)CC(=O)NCCCOCCCNC(=O)CS(C)(=O)=O CC(C)CCCCC(=O)N(C)CCC1CCN(C(=O)C=2[NH1]C(Cl)=C(Cl)C=2N)CC1 CC12CC(CN=C3C=CC4=N[NH1]C=C4C(C(=O)OC)=C3F)(CCO1)C2 C=C1C[C@H1]1C(=O)NCC2=CC=C(OC3=CC(C(F)(F)F)=CC=C3Br)C=C2 CC(C)(CCCNC(=O)C1=C(Cl)C=NC=C1Cl)NC(=O)C2C=CC=CC=C2 C[C@@H1]1CCOC[C@H1]1C(=O)N2CC[C@H1](C(C)(C)C(=O)N3CCNC(=O)CC3)C2 CC[C@@H1](F)C(=O)N1CCCO[C@H1](CNC(=O)C=2OC=CC=2Cl)C1 CC(C)N1N=CC=C1C(=O)NCC23CCC(CNC4=NC=NC(O)=C4Br)(CC2)CO3 CC1=NSC(N)=C1C2=CN(C3CC(C(=O)N4CCN(C)[C@@H1](C)C4)C3)N=N2 CC1=NC=C(C(=O)N2CCC[C@H1](N(CCF)C(=O)C=3C=C[NH1]N=3)C2)C=C1C#N CN(C)CC(=O)N[C@H1]1C[C@@H1](O)[C@H1](NC(=O)CCCC(F)F)C1 CC1=CSC(CC(=O)NCCN(C(=O)C2=NN(C)C3=C2CCC3)C(C)C)=C1 O=C(N[C@H1]1CC[C@@H1](CO)CC1)C2=CC=C(C3=CC=CC(F)=C3)S2 CCN(C(=O)C1=C[NH1]C2=CC=NC=C12)C3CCN(C(=O)CC=4C=C(C)ON=4)CC3 C[C@H1](O)CN1C=C(C(=O)N2CCC(N(C)C(=O)[C@H1]3CCCCS3)CC2)C=CC1=O COC(C)(C)CCC(=O)NC[C@@]1(F)CC[C@H1](NC(=O)C2=CC=C(CO)N=C2)C1 C=CCC1(NC(=O)C2=NC=C[NH1]C2=O)CN(C(=O)CC3=CSC(Cl)=N3)C1 C=CCSCC(=O)N[C@H1](CN(C)C)C(=O)N[C@@H1](C)C1=NC=C(F)C=N1 CS[C@H1](C)CCC(=O)NCCOC1CN(C(=O)CNC2=CC=CC=N2)C1 CC(=O)N(C)[C@@H1](C)C(=O)N1C[C@@H1](C(=O)N2CC(C)(O)C2)CCC1(C)C C#CC1=CC=C(C(=O)NC[C@@H1](CCO)C2=CC=CC=C2F)C(Cl)=C1 CC[C@@H1](C)C(=O)N[C@@H1]1CN(C(=O)C(C#N)=CC2=CC=CC=C2)C3(CCOCC3)C1 CC(C)N1C[C@H1](C(=O)N2CCN(C(=O)[C@H1]3CCCC34CC4)C[C@H1]2CO)CC1=O CC(=O)N[C@](C)(CO)C(=O)N1CC[C@@H1](NC(=O)C2(O)CCC2)[C@H1](CO)C1 C[C@H1](C[C@@H1](C)NC(=O)C1=CSN=C1C2=CC=CC=C2)NC(=O)C=3C=NN(C)C=3Cl C[S@](=O)C1(CNC(=O)N[C@H1]2CCCC[C@H1]2NC(=O)C(F)(F)F)CC1 CN(C[C@@H1]1CCCN(C(=O)C2=CC(Br)=CN=C2Br)C1)C(=O)CC3=CC=C(Cl)C=N3 COC1(CC(=O)NC[C@@H1](C)N(C)C(=O)CC2(OC)CCC2)CCCC1 O=C(NCCN1CCOC1=O)C2=CC=CC=C2C(F)(F)CN CC1=NC(C(=O)N2[C@H1]3CC[C@H1]2CC(N(C)C(=O)CC=4C=NN(C)C=4C)C3)=C(C)S1 C[C@@H1]1C[C@@H1](C(=O)N2CCNC(CC3CC3)C2)CN(C(=O)C4=CC([N+1](=O)[O-1])=N[NH1]4)C1 C[C@@H1](CN(C)C(=O)C1=CC(F)=C(F)C=C1N)N(C)C(=O)C2=CN=C(C(C)(C)C)O2 O=C(NC[C@H1](NC(=O)[C@H1]1CCC=2SN=NC=21)C3CC3)[C@@H1](O)CN4C=NC=N4 CC1=CC(C)=C(C(=O)N2CC[C@@](C)(CNC(=O)CCC=3C=CSC=3)C2)C(C)=N1 O=C(CC1=CC=C(O)C(F)=C1)NCC2(CNC(=O)[C@@H1](O)C3CCCCC3)CCC2 CC(C)(C)OC(=O)N[C@H1]1[C@H1]2[C@@H1](O)C[C@@H1]1CN2C(=O)C3=CC=C4C(=C3O)CCO4 O=C(NC1(C2=CC=CC=C2)CN(C(=O)CCCC3CC3)C1)[C@H1]4C[C@@]45CC5(F)F CC#CCCCC(=O)N1C[C@@]23CCC[C@]2(C1)CN(C(=O)C[C@@]45CCC[C@H1]4C5)C3 NC1=CC(C(=O)N2C[C@@H1](NC(=O)C3=C[NH1]C(=O)C=N3)C4(CC4)C2)=CC(F)=C1O COCC1=CC(C(=O)NCC23CCC(CC2)CN3C(=O)C(C)(C)OC(C)C)=NO1 O=C(NC[C@H1]1CC2=CC=CC=C2CN1C3=CN=C(F)C=N3)C=4OC=C5C=4CCOC5 C[C@@H1]1COC[C@H1](CC(=O)N2CCC([C@H1](C)NC(=O)C=3C=N[NH1]C=3)CC2)O1 CNC(=O)[C@H1](C=1C=CSC=1)N2CC[C@H1](O)C[C@@H1]2C(N)=O C=CC1=CC(F)=CC(C(=O)N2CCCN(C(=O)[C@H1](O)CC(N)=O)[C@H1](C)C2)=C1 CCCC1CN(C(=O)[C@H1]2CCN(C(=O)C(CC)(CC)OC)CCO2)C1 CN1CCN(C(=O)[C@@H1]2C[C@@H1]2C=3N=C[NH1]N=3)C[C@@H1]1CNC(=O)C4=CC([N+1](=O)[O-1])=C[NH1]4 COCC1=NC(O)=CC(N2C[C@@H1](C)CN(C(=O)C3(O)CC3)C[C@H1]2C)=N1 CCOC(=O)[C@H1]1C[C@](F)(C(=O)NC[C@@H1](C)CNC(=O)C2=CN=C(CC(C)C)S2)C1 C[C@@H1](NC(=O)CNS(=O)(=O)C1=C[NH1]C2=NC=CC=C12)C3=CC=CC(Cl)=C3Cl C[C@@H1](O)C(=O)N1CC[C@H1](CC(=O)N2CC3=NN=CN3C[C@@H1]2C(=O)O)C1 CC(C)C1=CC=C(C(=O)N[C@](C)(CNC(=O)CC2CC(F)(F)C2)C(C)C)S1 CC=1C=CN([C@H1](C(=O)N2CC[C@@H1](NC(=O)CC3(CO)CC3)[C@H1](O)C2)C(C)C)C=1 C[C@@H1]1C[C@@H1](NC(=O)[C@H1](O)C(F)F)CCN1C(=O)C2=CC(O)=CC=C2Cl C=C=CCC(=O)N[C@H1](CNC(=O)C1=CC=C2C(=C1)CC(C)(C)C2)C3CCC3 C[C@@H1](CC(=O)NC12CCC(CC1)N(C(=O)C=CC(=O)NC3CC3)C2)NC(N)=O CC(C)(C)O[C@H1]1C[C@@H1]1C(=O)NCCSC(C)(C)C CC1=CC=CC(NC(=O)NCC(=O)NCC[C@@H1](C)N(C)C(=O)C23CC(C2)C3)=C1C CC(C)P(=O)(CC(=O)NC[C@H1](C)NC(=O)[C@@H1](O)C1=CC=C(F)C=C1F)C(C)C CC[C@H1]1[C@H1](CC(=O)NCC2(NC(=O)CN3N=NN=C3C)CCCC2)C1(F)F COC1(C(=O)N[C@@H1]2CCOC3(CCCC3)C2)CCN(CC4=C(Br)C=NN4C)CC1 COC[C@]1(CNC(=O)[C@H1]2CCC3=CC=CC=C3O2)CCCN1C(=O)C(C)C C=CC[C@@H1](OC)C(=O)N(C)[C@@H1]1CCC[C@@H1]2CN(C(=O)C3=CN=C(C)N3C)C[C@H1]21 COCC1(C(=O)NC2=CC=CC(CNC(=O)CN3C=C(C)C=N3)=C2)CC(F)(F)C1 O=C(N[C@@H1]1CCC[C@H1]1CNC(=O)[C@H1]2CCCS2)C3=CC=4OC=CC=4S3 CCC1=CC=C(NC(=O)/C=C/[C@H1](C)NC(=O)CS(=O)(=O)CC)C(F)=C1 COC(=O)[C@]1(C)C[C@H1](C(=O)N2C[C@H1]3C[C@H1](NC(=O)CCS(N)(=O)=O)C[C@H1]3C2)C1 CC1=NC(CCNC(=O)[C@@H1]2CN(C(=O)CCC(=O)C3CC3)CCN2C)=CS1 CC1=CC=NN1CC(=O)NC2CCC(NC(=O)C=C[C@@H1]3CCOC3)CC2 C[C@](O)(C(=O)N[C@@H1]1CCCC[C@@H1]1NC(=O)CCC2=NN=CS2)C3CCC3 CCN(C(=O)C1=CC=C(F)C(Cl)=C1F)[C@@H1]2CCCN(C(=O)C3=CN=CC(O)=C3)C2 COC1=C2SC=C1C(=O)NC[C@H1]3C=CCN3C(=O)CSC=CC=CC=[N+1]2[O-1] C[C@@H1](CO)C(=O)N(C)[C@@H1]1CCCC[C@H1]1N(C)C(=O)C2=CC=C3C(=C2)COCO3 CCCC[C@@H1](O)CC(=O)NC12CC(CNC(=O)C3=N[NH1]C(C)=C3O)(C1)O[C@H1]2C CC(C)[C@H1](C)CC(=O)N[C@@H1](C)CC1=CC=C(CNC(=O)C=2C=CSN=2)C=C1 CCN=C1[NH1]C(C)=C(C(=O)NC2CCN(C(=O)CC3=CC=C(Cl)C=N3)CC2)S1 C#CCCC(=O)N1CCC2(CN(C(=O)[C@H1]3COC4=CC=C(Cl)C=C4C3)C2)C1 C=CCCCCCC(=O)N[C@@H1]1C[C@H1]1CNC(=O)CCC(=O)C2=CC=NC=C2 CSC1=CC=C(C(=O)N2C[C@H1](C#N)[C@@H1](NC(=O)C3=CC=C(F)C(Cl)=C3)C2)C(C)=C1 CO[C@](C)(C(=O)N1CC[C@@H1](C)N(C(=O)CCSC(F)(F)F)CC1)C2CC2 CC(C)(C)OC(=O)NCC1=CC(C(=O)NCC2=C(F)C(F)=C(F)C(F)=C2F)=NO1 C=C(Br)CC(=O)N[C@]12CCC[C@@H1]1N(C(=O)CCN3C(C)=CC=C3C)CC2 CC=1OC(C(=O)N2CC(C)(C3=CN([C@@H1](C)CO)N=N3)C2)=CC=1S(=O)(=O)N(C)C CN1N=NC(/C=C/C(=O)N[C@@]23CC[C@@H1](CN(C(=O)CC4=CCCC4)C2)C3)=N1 CCCNC(=O)[C@H1]([C@H1]1CCSC1)N(C)[C@@H1](C)C2=CC=C(S(C)(=O)=O)C=C2 CC1=CC=C(CO)C(NC(=O)[C@H1]2CC23CC(NC(=O)C4(C5(C)CC5)CC4)C3)=C1 CCN1CC[C@@H1](C(=O)N2C[C@H1](C)C3=CC=C(S(=O)(=O)N(C)C)C=C3N2C)C1 CCC1=CC=CC=C1OCC(=O)N2CCN(C(=O)[C@@H1](C)[C@@H1]3CCCO3)C4(CC4)C2 C=C(CCNC(=O)C1=CC=C(C#N)C(OC)=C1)CNC(=O)C2(O)CCC(C)CC2 CC(C)[C@@]1(C)CC[C@H1](NC(=O)C=2C=NC3=N[NH1]C(Br)=C3C=2)C1 CC(C)P(C)(C)=O COC[C@@]1(C2CC2)CCCN1C(=O)[C@H1]3CC4(CCCC4)CCN3 NC1=NC=CN=C1C(=O)N[C@H1]2C[C@H1](CNC(=O)CSC=3C=CSC=3[N+1](=O)[O-1])C2 CC[S@@](=O)CC(=O)N1CCN(C(=O)C=2C(OC)=NSC=2OC)C[C@@H1]1CF C=C(C)[C@@H1]1OCC[C@@H1]1C(=O)NCC2CC(O)(CNC(=O)CC3=NC=C(C)S3)C2 C[C@@H1](C(=O)N1C[C@H1](O)[C@H1](NC(=O)C2CN(C(N)=O)C2)C1)N3C=C(Br)C=N3 COC1=CC=C(C(=O)NC[C@@H1]2C[C@H1](C)N(C(=O)C3=C[NH1][NH1]C3=N)C2)C=C1 CO[C@H1](C)CCC(=O)NC1(CCC(=O)NCC(Cl)=CCl)CCCC1 C=C(Br)CC(=O)N1CCCC[C@@H1]1C2(NC(=O)[C@@H1](CC)NC(N)=O)CC2 C[C@@H1]1CC2(CCN(C(=O)C3=CC(Cl)=NO3)CC2)CN1C(=O)C4=CCCC4(C)C C[C@@H1](C#N)C(=O)NCC1=CN([C@H1]2CCCN(C(=O)C3=CC=CC=C3Cl)C2)N=N1 CC=C[C@H1](O)C(=O)N1CCN(C(=O)C=2C=NN(C)C=2C(C)C)[C@@H1](C)C1 C#CCSCC(=O)NC[C@H1]1CCCCCN1C(=O)[C@H1]2CC23CCC(F)(F)CC3 CCN1CCC(C(=O)NC[C@H1]2CC3(CC3)CN2C(=O)C4=COC(C(C)C)=N4)CC1 NC(=O)C(=O)NC12CC(NC(=O)C[C@H1]3CC4(CCO3)CC4)(C1)C2 O=C(CC=1C=C[NH1]N=1)NC2CC(C3=CN([C@H1]4CCC5=C(F)C=CC=C54)N=N3)C2 CC=1N=C(C=CC(=O)N(C)[C@H1](C2=CC=C(Cl)C=C2)C3=NC=CN3C)[NH1]C=1C CN1CCC[C@H1](CC(=O)NCCN(C(=O)CCCS(N)(=O)=O)C2CCCC2)C1 O=C(CCC1=CC=CC=C1[N+1](=O)[O-1])N(CC2(O)COC2)[C@@H1]3CCNCC34CC4 CCCCC(=O)NC(CC)(CC)CNC(=O)CS(=O)(=O)CC1=CC=CS1 C#CCSCC(=O)N1CCOC[C@H1]1CCNC(=O)C2CC=CC2 CSC1=CC=C(C(=O)N(C)C[C@@H1]2CCCN(C(=O)[C@@]3(C)CCN(C)C3)C2)O1 CC(C)CS(=O)(=O)CC(=O)N(C)[C@H1]1CN(C(=O)[C@@H1]2[C@@H1](C)[C@H1]2C)CC1(C)C CC(C)CCC[C@@H1](C)CNC(=O)C1=CCN(C(=O)[C@@]2(C)CCCN2C)C1 C=C1CC([C@H1](N[C@@H1]2CC[C@H1](CO)C2)C3=NN=NN3CC=4N=NN(C)N=4)C1 CC1=CC=CC2=NC=NC(N(C)[C@H1](C)CCNC(=O)C3(C)CC4(CCC4)C3)=C12 C[C@@H1](CN(C)C)C(=O)N(C)CCC(=O)N1CCC2=CC=NC=C21 CC1=CC(N[C@H1]2C[C@H1](CNC(=O)C3=CC=C4N=NN(O)C4=C3)C2)=NC(C5CC5)=N1 C[C@@](F)(C(=O)NCCC[C@H1]1CCCN1C(=O)C2=CC=C3SN=NC3=C2)C(F)(F)F C[C@H1]1C2=CC=CN=C2CCN1[C@@H1](C(=O)NCC(F)F)C3=CC=C(OC(F)F)C=N3 CO[C@H1](CCNC(=O)C[C@H1]1CCCSC1)CNC(=O)C=CC2=CC=NC=N2 FC1=CC=C(Br)C=C1C2CCN(S(=O)(=O)CC3=CC=C(Br)C=C3)CC2 CC1=CC=CC(C(=O)NC[C@]2(F)CCN(C(=O)COC3=CC=CN=C3)C2)=C1C O=C([C@@H1]1O[C@H1]2CC[C@H1]1C2)N3C[C@@H1]4CCC[C@H1](C3)N4C(=O)C5=CN=C6C(=C5)NCC6 COC(=O)C[C@@H1](C)CC(=O)NCC1CCN(C(=O)C=2SC=CC=2C(F)F)CC1 CCOC(=O)CN1N=C(C2=NC=CS2)N=C1C3=CN=CC=N3 CCC[C@H1](O)CCN[C@@H1](C1=C(C)C(C)=CC(C)=C1C(C)(C)C)C2=NN=NN2CC CC[C@@](C)(CO)C(=O)N(C)C1CN(C(=O)[C@H1](OCC(C)C)C(C)C)C1 C[C@H1]1C[C@@H1]1C(=O)NCCC(=O)N2[C@H1]3C[C@H1]2CN(C(=O)C4=CC=CN4C)C3 CC[C@H1]1CN(C(=O)[C@]2C3CC[C@H1]2N(C(=O)[C@@H1](O)CC(C)(C)C)CCC3)CCN1C CN(C[C@@H1]1COC(=O)N1)C(=O)[C@]23CCC[C@H1]2N(C(=O)CC4(C)CC4)CC3 C#CCC1(NC(=O)C2=CC(CNC(=O)[C@H1]3C[C@H1](C)CO3)=NN2C)CCC1 CC1(NC(=O)[C@H1](C2=CC=C([N+1](=O)[O-1])S2)N3CC[C@@](CO)(CC(C)C)C3)CC1 CO[C@H1](C)CN1CCC(O)(C(=O)N[C@H1]2CC(=O)N(CCC(C)C)C2)CC1 CNC=1SN=C(C)C=1C(=O)N[C@H1](CCNC(=O)C2(C3CCC3)CC2)C(C)C CC(=O)N(CC(=O)NC[C@H1]1CN(C(=O)C2=CC=CC(F)=C2)CC13CC3)C(C)C C#CC[C@@H1]1CCN(C(=O)CN(C(=O)C=CCOC)C2CCC2)C1 CC[C@H1](COC)C(=O)N1CC[C@@H1](NC(=O)C2CS(=O)(=O)C2)C13CC3 C#CCCCNC(=O)C1(CNC(=O)CC[C@@H1](C)SC)CC2(CC2)C1 CC1=CC(C(=O)N2C[C@@H1]3C[C@]3(NC(=O)C4=CC=NN4CC#N)C2)=C(C)C=N1 COC(=O)CC(=O)N1CC[C@@H1](CO)[C@@H1](NC(=O)CCSC2=CC=C(C)C=C2)C1 CCC(=O)NCC(=O)N1CC(CO)(NC(=O)C2=C(C)OCC2)C1 COCCOC1=CN=CC(C(=O)N[C@H1](C)CN(C)C(=O)C=C(C)Cl)=C1 COCC(=O)N(C)CC(=O)N1CC[C@]2(C[C@H1]2C(=O)NC=3C=NN(CCO)C=3)C1 O=C(N[C@@H1]1CC[C@@H1](NC(=O)C2CCC3(CC2)CC31)C)C4=CC5=CC=CN=C5S4 CNC(=O)CCC(=O)N[C@@H1]1CN(C(=O)C2=CC=C(C(F)F)C=C2)C[C@H1]1O CC(=O)C1=CC([N+1](=O)[O-1])=CC=C1N2CC[C@@H1]([C@H1](C)NC(=O)C3=C(C)OCCS3)C2 O=C(CC1=CC=C(Cl)C(Cl)=C1)NCC2[C@H1]3CN(CC4=NC(C5CCC5)=NO4)C[C@H1]23 C#CC[C@]1(C(=O)N(CC)CC2=CC=CS2)CCN(C(=O)C3=CC=C(C)[NH1]3)C1 O=C(N[C@H1]1C[C@@H1](CCNC(=O)[C@H1]2CN3CCC2CC3)C1)C4CC(=C5CC5)C4 CC1=CC=C(CC(=O)N[C@@]2(C(=O)NC[C@H1]3C=CCCC3)CC2(C)C)C=C1 CC=CC=CC(=O)NC[C@H1]1[C@@H1]2CN(C(=O)C=3OC4=CC=CC=C4C=3COC)C[C@H1]12 CC(C)CC1=CC=C(CC(=O)N2C[C@@H1](NC(=O)C3(O)CC3)[C@H1](C4CC4)C2)C=C1 CC1(C)C[C@@H1](C(=O)NC2CC(NC(=O)C=3C=C[NH1]C(=N)N=3)C2)CCO1 C=C[C@@H1]1OCC[C@H1]1C(=O)N[C@@H1](C)CCNC(=O)C2=CC=C(OC)C=C2C(F)F CO[C@H1](C(=O)NCC[C@@H1](O)CNC(=O)CC(=O)N(C)C)C1=CC=C(Cl)C=C1 C[C@H1](CNC(=O)C1=CN(C)C(O)=N1)NC(=O)C2=CC(C(F)(F)F)=C(Cl)C=N2 C=C[C@@H1]1C[C@]1(CO)CNC(=O)C2CCN(CC3=CN4C(=N3)CCCCC4)CC2 CS[C@@H1]1CN(C(=O)[C@@H1](CO)NC(=O)C(F)(F)F)C[C@H1]1NC(=O)C2(CO)CCC2 CCC=1N=C(C)N(C)C=1C(=O)NC[C@@H1](NC(=O)CCOCC2CC2)C3CC3 C=C[C@H1]1CCN(C(=O)C2=CC=CC(CNC(=O)C3=CCSC3)=N2)C1 C=C[C@H1]1CN(C(=O)C2=CC=CN(C(C)(C)C)C2=O)C[C@H1]1NC(=O)C=3[NH1]C=CC=3C COCC1(CNC(=O)[C@H1]2CC=CCC2)CN(C(=O)C=3C=CN(C)N=3)C1 CC(=O)N[C@@H1](C)C(=O)N1CC2(CCCN(C(=O)[C@]34CCC[C@H1]3CC(=O)C4)C2)C1 O=C(CC1=CC=C(Cl)C=C1)N[C@@]23C[C@@H1]2CN(C(=O)[C@@H1]4CC5CCC4CC5)C3 C=CCOCC(=O)NCC1CC(O)(CNC(=O)[C@H1]2CCC3=NN=C(C)N3C2)C1 CCS[C@@H1](C)C(=O)NC(C)(C)CCNC(=O)C=1C=NN2C=1S(=O)(=O)N(C)CC2 CC1=CC=C(C)C(C(=O)NCC[C@@H1](C)NC(=O)[C@@H1]2CCOC2)=C1 COC1=CC=C(F)C(OC)=C1C(=O)N(C)CCNC(=O)CC2=CN=C(C)O2 COC1=NSC=C1C(=O)N2CC[C@](CO)(NC(=O)[C@H1]3CCCC(C)(C)CC3)C2 CC(=O)C1=CSC(C(=O)N2CCN(C(=O)[C@@H1]3C[C@H1]4CC[C@@H1]3C4)[C@H1]5CC[C@H1]52)=C1 N=C1[NH1]C(C(=O)NC[C@@H1]2CCN(C(=O)[C@H1]3CCC(F)(F)CO3)C2)=CS1 CC1(C)C[C@@H1](CC(=O)N[C@H1]2C[C@H1](NC(=O)CCCN3C=CN=N3)C2)CO1 CC[C@@H1](C(=O)N[C@H1](CO)C(=O)NC1=CN=CC(C#N)=C1)N(C)C CC1=CC(C(=O)NC[C@H1](C)N(C)C(=O)C2CCC=CCC2)=C(C)N1[C@H1]3CCOC3 C#CCN1C(C)=CC(C(=O)N(CCNC(=O)CCC=2C=N[NH1]C=2)C(C)C)=C1C CCOCC(C)(C)CNC(=O)[C@]12C[C@@H1]1CCN2C(=O)[C@H1](OC)C3CC3 CC1=NOC(C(F)F)=C1C(=O)NCC(C)(C)CNC(=O)C=2C=CC3=NN=CN3C=2 CN1N=C(Cl)C=C1C(=O)N2CC(CN3C=C(/C=C/C4=CC=CO4)N=N3)C2 CCOC(=O)[C@@]1(C)C[C@@H1]1C(=O)N2CCN(C(=O)C3=CN=NN3CC)[C@H1](CC)C2 CN(C)C(=O)CC(=O)N1C[C@H1](CC(=O)N2CCC(=C(F)F)CC2)C3(CC3)C1 COC1=CC(C)=C(CC(=O)NC2CN(C(=O)CC[C@@H1](C)N(C)C)C2)C(C)=C1 C[C@H1](O)C(=O)NCC1=CC=C(CNC(=O)CN2N=CC=C2N)C=C1 CN1C([C@@H1](O)C2=CC=CC=C2)=NN=C1N3CCN(CC=4C=N[NH1]C=4)CC3 CN(CCOCCC(=O)N(CC1CC1)C2CC2)C(=O)[C@@H1]3CCC(F)(F)C3 CC1=NN(CC(=O)N2CC[C@]3(CNC(=O)CN(C)C(C)C)CCC[C@@H1]23)C(C)=C1C CC(C)(C)[C@H1](C#N)C(=O)NC[C@@H1](O)C(=O)NC=1C=CN2N=CC=C2C=1 CC1=CC=C(C(F)(F)C(=O)NC[C@H1]2CCCN(C(=O)C3=COC(Cl)=C3)CC2)N=C1 CC(=CC(=O)N[C@H1]1C[C@@H1](NC(=O)C2=CN=C3C(=C2)N=NN3C)C1)C4=CC=CN=C4 CC[C@@H1](NC(=O)[C@@H1]1[C@H1](O)CCN1C2=NC=NC3=C(F)C=CC=C23)C4=CC=NC=C4 CC1(C)C[C@@H1](C(=O)N2CCCC[C@@H1]2CNC(=O)C3=CN=NS3)CCO1 CC(=O)NCC(=O)NC[C@]1(C)CN(C(=O)CCC2=CN=C(C3CC3)O2)C[C@H1]1C C[C@H1](O)C1=CN(CC(=O)N2CCC[C@@H1]2CCNC(=O)C3=CC(=O)N(C)C=N3)N=N1 C[C@H1](C1=CC=C(C(=O)N2CC[C@H1](NC(=O)CCCCCF)C(C)(C)C2)C=C1)F COCC[C@H1](CNC(=O)[C@]1(C)CC1(C)C)NC(=O)CCCC2=NC=C(C)O2 CN1CC(=O)NC2=CC=C(C(=O)N(C)CCNC(=O)C3=CC(Cl)=CC=C3Cl)C=C21 C#CCOCCC(=O)N1CC[C@H1](NC(=O)C2=NC=CN3N=C(C)C=C23)[C@@H1]1C CCN(CC)[C@@H1](C)CNC(=O)[C@@H1]1CCC[C@@H1](C)CC(C)(C)C1 COC=1C=C(C(=O)NC/C=C/CNC(=O)C2=CN=CC(C)=N2)[NH1]N=1 CCC1=CC=CC(F)=C1C(=O)N[C@H1]2COCC[C@H1]2NC(=O)C3=CC(Cl)=CC=N3 C[C@H1]1[C@H1](CO)CCN1CC2=C[NH1]N=C2C3=CC=C(C#N)C=C3 O=C(NC[C@H1]1CCN(C(=O)C2=CC=C(F)C(Br)=C2)C1)C3=C(Cl)CCC3 C=C[C@@](C)(CC)C(=O)N1CCC([C@H1]2CCCN2C(=O)CC3=CSC=N3)CC1 COCCOCC1=CC=C(C(=O)N[C@H1]2C[C@@H1](CNC(=O)C[C@H1]3C=CCC3)C2)C=C1 CC1=C2C(=NN1C)C[C@H1](NCC3=CC=C4N=C(O)OC4=C3)CC2 CCC=1C=C(CCNC(=O)[C@]2(N=[N+1]=[N-1])CCN(C(=O)C=CI)C2)ON=1 CC(=O)N(C)C[C@@H1](C)N(C)C(=O)C1([C@@H1](C)NC(=O)CN2[NH1]C=NC2=N)CC1 CC[C@@H1](CNC(=O)CN1C=C(C)C=N1)NC(=O)C[C@H1](CC)C(C)(C)C CC1=CC=C(Cl)C(C(=O)N[C@@H1]2C[C@H1](C)N(C(=O)[C@@H1](C)N3C=NC=N3)C2)=C1 CN1C=C([C@H1]2CCCN(C(=O)C(=O)NC3=C(Cl)C(F)=NC(F)=C3Cl)C2)C=N1 CC[C@@H1](C)CN(CC)C(=O)C1=CC=C(CNC(=O)[C@@H1](O)C(C)(C)CC)S1 CC1=CC=C(Cl)C(N)=C1C(=O)N2CCC[C@@H1]2CNC(=O)C3=NC=NC=4C=CSC3=4 FC1=CC=CC(F)=C1N2CC[C@H1](NCC3=CC4=C(Br)C=CC=C4O3)C2 CSC1=CC(C(=O)NC[C@@H1]2C[C@@H1](NC(=O)CN3N=NN=C3C4CC4)CCO2)=CO1 CC[C@H1]1CN(C(=O)C2=N[NH1]C=C2OC)CC[C@@H1]1NC(=O)C=3OC=CC=3C4CC4 CN(CC(C)(C)NC(=O)C1=CC(=O)C=C(Cl)[NH1]1)C(=O)CN2CCOCC2=O O=C(CN1C=CC=NC1=O)N[C@@H1]2CC[C@@H1]2NC(=O)[C@@H1]3CCCC4=NC=NN43 CCCN1C=CC(C(=O)N(C)[C@H1](CC)CNC(=O)C2=CC=NC=C2)=N1 CC[C@@H1]1OCC[C@H1]1C(=O)N2CCCC3(CN(C(=O)C4=CN=CC=C4N(C)C)C3)C2 CC(=O)N[C@H1]1CC[C@@H1](C(=O)N(C)CC(C)(C)CNC(=O)C2=NC(Cl)=CS2)CC1 CC(C)CC[C@@H1]1CCCN1C(=O)COC2CN(C(=O)C[C@@H1]3CCC(=O)C3)C2 C=C=C[C@@H1](C)C(=O)NC[C@@H1]1CN(C(=O)CS(=O)(=O)N(C)C)CCO1 O=C(CN1C=NN=C1)NC2(C3CCN(C4=NC=NC=5C=C(Br)SC4=5)CC3)CC2 CC1(C)C[C@@H1](NC(=O)[C@@H1]2CCCCS2)CN(C(=O)C3=CN=C4SC=CN4C3=O)C1 C[C@H1](NC(=O)C1(C)CC=CC1)[C@@H1](NC(=O)CCOCCCO)C2=CC=CC=C2 CC(C)N(CCN(C)C(=O)[C@@H1]1CCC[C@@H1]1C)C(=O)[C@H1]2CCCC(F)(F)CC2 O=C(/C=C/CN1CCCCC1)NCC[C@@H1]2CCCN2C(=O)[C@@H1]3C[C@@H1]4C=C[C@H1]3CC4 CC(=O)CC1(C(=O)N2CCC[C@@H1]2CN(C)C(=O)C=C3CCC3)CCCC1 CC1(C)C[C@@]1(C)C(=O)N2CC(O)(CNC(=O)COC3=C(Cl)C=CC=C3Cl)C2 CC(C)C1=NC=CC(C(=O)N[C@@H1]2CCN(C(=O)C3(CF)COC3)C[C@H1]2C)=N1 CN1CC(C(=O)N[C@H1]2C[C@@H1](CO)N(C(=O)C[C@@H1]3CCC[C@H1](C4CC4)O3)C2)C1 COCCO[C@@H1](C)C(=O)N(CCNC(=O)[C@@H1]1CCN(C)C1=O)C2CCCC2 C[C@H1](NC(=O)[C@H1]1CC12CCC(F)(F)CC2)C3CN(C4=NC=C(F)C=N4)C3 CO[C@@H1](C(=O)N1CC[C@](C)(NC(=O)CCCC2=CSC(=N)[NH1]2)C1)C(C)C FC=C1C=CC(OC(SC[C@@H1]2COCCO2)=CC3=CC=CC=C3CCl)P=N1 CC1=CC=CC([C@@H1](C)C(=O)N[C@@H1]2C[C@H1](NC(=O)C3(C(F)(F)F)CC3)C[C@H1]2O)=C1 CC(C)(CO)NC(=O)[C@H1]1CCCCCN1C(=O)[C@]23COC[C@H1]2C3 O=C(CCC1=CC=CS1)N2C[C@@H1]3C[C@H1](C2)N3C(=O)C=4C=NN5C=4OCC5 COC(=O)C1=CN=C(N(C)C[C@@H1]2CCCN(C(=O)CCOC3CC3)C2)C(Cl)=C1 CC[C@@H1](CC(=O)N1CC(C)(C)C[C@H1]1CNC(=O)C2=CC(C)=C(Cl)S2)SC CC(C)CN(CC(=O)N[C@]1(C)CCSC1)C(=O)CCOCC2CCC2 O=C1CC[C@@H1](C(=O)N[C@H1](CNC(=O)C2=NC=CC=3C=C[NH1]C2=3)C4CCC4)CCO1 O=C(C=CCl)NCCC(=O)N1CC[C@@]2(CCN(C(=O)C3CC(=O)NC(=O)C3)C2)C1 CC(C)(CCNC(=O)C=CC1=CC=CS1)CNC(=O)[C@H1]2C[C@H1]3CCCN(C2)C3 CC1=NC(C)=C(CN[C@H1]2C[C@H1](C(=O)NC3=CC=CC(Cl)=N3)C2)[NH1]1 COCC1=CC=CC=C1CN[C@@H1](C)C2=NC(C3=CC=CC=C3)=NO2 CC1(CC(=O)N2C[C@@H1](C)[C@@H1](O)C2)CN(C(=O)CSC(F)F)C1 CC=1SC=C(C(=O)N2CC[C@H1](CNC(=O)[C@@H1]3[C@H1]4CCC[C@H1]43)C2(C)C)C=1N COC(=O)C1=CN([C@H1]2CCCN([C@H1](C(=O)NC(C)(C)C)C3=CN=CC=C3C)C2)N1 CCCC=C(CC)C(=O)NCCCC(C)(C)NC(=O)C[C@@H1]1C(=O)N(C)N=C1C COC(=O)C[C@@H1](C)C(=O)N(CC(=O)N(C)C1CC(C)(C)C1)C2CCC2 COC1=CC=C(C(=O)N[C@@H1]2C[C@H1](O)CN(C(=O)CCC3=CC=C(F)C=C3Cl)C2)O1 C[C@@H1](CC(=O)N1CC2(CCN(C(=O)C3=C[NH1]C=C(F)C3=O)CC2)C1)C(F)(F)F CCN1N=CC=C1[C@H1](C)NS(=O)(=O)C2=CN=C(O)C3=CC=CC=C23 O=C(NC[C@@H1]1CN(C(=O)[C@@H1]2CCNC2=O)CC1(F)F)[C@H1](O)C3CCOCC3 N#CC1=NC=CN=C1N2CCC[C@]3(CCN(C(=O)[C@@H1]4CCN5N=CN=C5C4)C3)C2 C/C=C/C[C@@H1](NC(=O)C=1C=C(CO)OC=1C)C(=O)N(C)CCCCCCCCC CCCCC1=NC(CN2CC[C@@H1]2CNC(=O)CC3=CC(C)=CC=C3C)=NO1 COC1(CNC(=O)[C@]23CCCN2C[C@H1](O)C3)CCN(C(=O)[C@@H1](C)OC)CC1 O=C(CC(F)F)NCCCNC(=O)CO[C@@H1]1CC1(F)F CC(=CNC(=O)CCC1(C#N)CCN(C(=O)OC(C)(C)C)CC12COC2)C(=O)O COCCOCCOCCNS(=O)(=O)C1=CC=C(N[C@@H1]2CCC[C@@H1](F)C2)C=C1Br COC1=CC(C#N)=CC=C1OCC(=O)N[C@@H1](C)C[C@H1]2CNCCO2 CC1=C[NH1]C=CC1=NC2CN(C(=O)NCCC3CC(O)C3)C2 CC(C)(C)OCC(=O)NCC1(C(=O)NCC2(Cl)CCC2)CC1 O=C(C[C@@H1]1CCCC[C@@H1]1O)N[C@@H1]2CCN(C(=O)C34CCCN3CCCC4)C[C@@H1]2F COC1=CC=C(Br)C=C1N2C=C(C3CCN(C(=O)C4(F)CC=CC4)CC3)N=N2 CO[C@H1](C)[C@@H1](CC(=O)N1CCC12CN(C)C2)NC(=O)CCC3=CN=CN3C COC(=O)C1(C)CC(NC(=O)C=2C=COC=2CNC(=O)C3=NC=CC=N3)C1 C[C@H1](F)[C@@H1](C)NC(=O)[C@@]1(CNC(=O)[C@@H1]2CC=CCC2)CCCO1 C[C@@H1]1C[C@@H1]2C[C@@H1]2C[C@@H1]1C(=O)NCC3[C@@H1]4CN(C(=O)CC=5C=COC=5)C[C@@H1]34 CCN1N=CC(C(=O)N[C@H1]2CC[C@H1](CNC(=O)C=3SC=C(C)C=3C)CC2)=C1Cl COCCN(CP(C)(C)=O)C(=O)C1=NC2=CC=C(Br)C=C2[NH1]1 C#CC1(O)CC(C(=O)N2CC(CN(C)C(=O)CCC3=CN=C[NH1]3)C2)C1 O=C(NCCCN1C=C(C2=CC=C(Cl)N=C2)N=N1)C3=CC=NC(Cl)=C3O CC1=NC2=CC=C(O)C=C2C=C1C(=O)NC[C@@H1]3CCCN3C(=O)C[C@H1](C)F CCCCS[C@H1](C)C(=O)N[C@@H1]1CC=C(C(=O)NC[C@@H1]2C=CCOC2)C1 O=C(CN1N=CN=N1)N[C@H1]2C[C@]3(C(=O)NCC4(O)CC=CC4)CO[C@H1]2C3 CC=1C=C(C)N(CC(=O)N2C[C@@H1](C(=O)N3C[C@@H1]4CC[C@H1](C3)OC4=O)C(F)(F)C2)N=1 CC(C)[C@@H1](C(=O)N1CC=C(CNC(=O)C2=CN(C)C=N2)CC1)C(=O)OC(C)(C)C C=CC[C@@H1](CC)C(=O)NC[C@H1](CC)NC(=O)C1=CC=C2C(=C1)C(=O)CCCC2 CN1CC(C(=O)N2C[C@H1]3CS(=O)(=O)C[C@]3(NC(=O)C(F)(F)C(F)F)C2)C1 CC1(C)CCO[C@H1]1C(=O)NC[C@H1]2CCN2C(=O)[C@]34CCC[C@H1]3OCC4 C[C@@H1]1CC[C@H1](NC(=O)COCC(C)(C)C)CN1C(=O)[C@@H1]2COC3=CC=CC=C3O2 CCN(CCCNC(=O)/C=C/C1=CC=C2OC=CC2=C1)C(=O)C3CN(C(C)=O)C3 CCC1=NOC([C@@H1](C)N2C(=O)CCN(CC3=CC=NN=C3O)C2=O)=N1 O=C(CN1CCOCC1)NC[C@@H1]2CC3(CC3)CN2C(=O)[C@H1]4CC5(CC5)CO4 COC(=O)[C@H1](C)NC(=O)[C@H1](CCCSC)N1CC[C@@H1](O)[C@@H1](C)C1 O=C(C=1C=CC2=CN=CN2C=1)N3C[C@H1]4C[C@]4(C(=O)NC5=CC=C(O)C=C5F)C3 CO[C@](C)(C1CC1)[C@H1](NCCC(C)(C)C)C2=NN=NN2CCCSC C#CC1=CC=CC(C(=O)N[C@H1](CCC)C(=O)NCCC2=CC=C(C)S2)=C1 CC=1[NH1]C(=N[C@@H1](C)C2=CC=C(Br)C=C2)SC=1C(=O)NCC3=CC=CC(Cl)=C3F CCC=1N=C2C=CC=CN2C=1C(=O)N3CC([C@H1](C)NC(=O)C4=NC=CC(C)=N4)C3 CC(C)CC=1ON=CC=1C(=O)N[C@H1]2COCC[C@H1]2NC(=O)C3=CC=C(CO)C=N3 CCC[C@@H1](CC1=CC=CC=C1)NCC2=CC=CC=C2COCCN O=C(N[C@@H1]1C=CCN(C(=O)[C@H1]2CCCSC2)C1)C3=CC(F)=C(F)C(Cl)=C3F CN1C=NC(CCC(=O)NC2C[C@@H1]3CCC[C@H1](C2)N3C(=O)C4=CC(Cl)=N[NH1]4)=C1 O=C(NC[C@@]12CC[C@@H1](C1)OC2)N3CCN(C(=O)C[C@@H1]4CCOC4)CC3 CC1=CC=C2C(=NC[C@H1]3CSCCO3)[NH1]C(=NC[C@@H1]4OCCC4(C)C)[NH1]C2=C1 COCC1(C(=O)NC[C@]2(C)CC(F)(F)CN2C(=O)C=C=C(C)C)CCCC1 COCN1C=CC(C(=O)NC[C@]2(F)CC[C@H1](CNC(=O)CCC=C(C)C)CC2)=N1 C=C[C@@H1](COC)NC(=O)C[C@H1](NC(=O)CC1=CC=CO1)C(F)(F)F CCCCS[C@@H1](C)C(=O)N1CCC(O)(CN2C=C(C3[C@H1]4CCCC[C@H1]34)N=N2)CC1 COC1=CC=C(OC)C(CC(=O)N2C[C@H1](F)[C@H1](NC(=O)[C@H1]3CC3(F)F)C2)=C1 O=CN1CCC[C@H1]1C(=O)N[C@@]23C[C@@H1]2CN(C(=O)C4=CC=C5C(=C4)CCCO5)C3 CC(C)=CC(=O)N(C)C[C@H1](CC1=CC=CC=C1)NC(=O)C=2C=C(O)N(C)N=2 CC1=CC2=CC(C(=O)NCC[C@H1](O)CNC(=O)[C@@H1](C)CC3CCC3)=CC=C2C=N1 CN(CCNC(=O)[C@@H1]1CCOCC12CCCCC2)C(=O)C3=CN=CC([N+1](=O)[O-1])=C3 O=C(CC1=C[NH1]C2=NC=CC=C12)N3CCN(C(=O)CCCF)[C@H1]4C[C@@H1]43 CN(C)[C@H1](CO)C(=O)N(CCNC(=O)[C@@H1]1C[C@H1]2CCC[C@H1](C2)C1)C3CCCC3 CC(C)(C)C1=NSC(N2CCC[C@H1]2[C@@H1]3CCN(C(=O)[C@H1]4C[C@H1]5C=C[C@H1]4C5)C3)=N1 CCCC(C)(C)C(=O)N[C@@H1](C)CCCNC(=O)[C@H1](C)CC(C)(C)C CC=1C=C(C)N([C@@H1](C)CC(=O)NCCCNC(=O)C23CC4CC(CC(C4)C2)C3)N=1 C[C@@H1](CN(C)C(=O)[C@@]1(F)CCOC1)N(C)C(=O)C2=CC=C(N3C=CN=C3)N=N2 CN(C)C(C)(C)CCC(=O)N1CCC[C@](C)(C(=O)NCC2=CC=C(F)N=C2F)C1 C[C@H1](CC(=O)OCC=1N=NN(C)N=1)C23CC4CC(CC(C4)C2)C3 CO[C@@H1](CNC(=O)CN(C)C1CCC1)CNC(=O)C2=CN=CC(C(C)=O)=C2 CC(C)(C)CCOC1=CN=CC=C1CNC(=O)N2CCC(C)(C)[C@H1](CO)C2 CCNC(=O)C(=O)N[C@H1]1CC[C@H1](C)N(C(=O)C2=CN(CC3CCOCC3)N=N2)C1 C[C@@H1](C(=O)NC1(CO)CCN(C(=O)CCC(C)(C)F)CC1)C2CCC2 CCN1C=C(CN(C)C(=O)C[C@H1](CC(C)C)NC(=O)C2(C(C)(C)O)CCC2)C=N1 COC[C@@H1]1CN(C(=O)CN(C)C(=O)C2CC2)CCN1C(=O)COCC(C)(C)C C[C@H1]1C(=O)C[C@@H1]1C(=O)N(C)CCCNC(=O)[C@H1]2C[C@@H1](O)CN2C CC1(C#CC(=O)N[C@@H1]2[C@H1]3C[C@@H1]2N(C(=O)C4=CC=C(C5CCC5)C=C4)C3)CC1 CCC1=NC(C(=O)N[C@H1](C)[C@@H1]2CN(C(=O)[C@@]34CC[C@@](C)(CO3)C4)CCO2)=CS1 CC1=CC=CC(C=CC(=O)N2C[C@@H1](NC(=O)C3CC(=C4CC4)C3)C[C@@H1](C)C2)=C1 C=CC[C@@]1(NC(=O)[C@H1](C)CF)CCCN(C(=O)CCN2C=CC=CC2=O)C1 C=CCC1(C(=O)NC(CC2CC2)CC3CC3)CN(C(=O)C4=COC=C4C)C1 CC1=CC(C(=O)N2CC[C@](CO)(C(=O)NCCCCCCF)C2)=NN=C1C CO[C@H1](CN=C1N=C(N(C)CC2=NC=CN2C)C3=C([NH1]1)C(C)=NN3CC)C(F)F O=C(NC=1C=NC2=CC=NN2C=1)C3=CSC=C3C4=CC=CN=C4C(F)(F)F CC(C)C[C@@H1](ONC(=O)C(C)(C)CCC#N)C(=O)NCCC1=CC=C(O)C=N1 O=C(N[C@@H1]1C=CCN(C(=O)C2=CC=C([N+1](=O)[O-1])S2)C1)C3=CC=NN=C3 C[C@H1]1CN(C(=O)[C@@H1](NC(=O)C#CC2CCCC2)C3(O)CCCCC3)C[C@@H1](C)N1C CO[C@H1]1C[C@H1](CNC(=O)N(CC(=O)OC(C)(C)C)CC2=CC=CO2)C1 N#C[C@H1](CC1CC1)C(=O)N(CC2CC2)C3CCN(C(=O)CC[C@H1]4CC4(F)F)CC3 CC1=NOC(N)=C1C(=O)N2C[C@@]3(NC(=O)C4=CN5C(=N4)SCC5)CC[C@H1]2C3 CC1=C(C(=O)N2CC[C@]3(NC(=O)C[C@H1]4CCCO4)C[C@H1]3C2)C=CC(Br)=C1F CC(C)(C)[C@@H1](CC(=O)N1C[C@H1]2[C@@H1](C1)OCCN2C(=O)C3C=CC=CC=C3)C(F)F COC1=CC2=C(C=C1OC)CC(N(C)CC3=CC=CC=C3OC(C)C)C2 C[C@]1(CNC(=O)CN2C=CC=C2)CC[C@@H1](NC(=O)C=CBr)C1 CC[C@@H1]1CN(C(=O)[C@H1]2CC23CCCCC3)CC[C@@H1]1NC(=O)CC=4C=COC=4 COC1(C(F)(F)C(=O)N[C@H1](C)[C@H1]2CN(C(=O)CNC(N)=O)CCO2)CCCCC1 O=C(NC[C@H1]1CNC(=O)O1)[C@@H1]2CCOCCN2C(=O)C3=CN=C(O)O3 CC1=CC=CC(C(=O)N2CCO[C@H1](C(=O)N(CCCO)CCCO)C2)=C1F CC1=CC=NC(C2=CN(CCCC(=O)N[C@@H1](CCO)C3=CC=CO3)N=N2)=N1 O=C(NC[C@H1]1[C@@H1]2C[C@H1]1CN2C(=O)C3=CC=C(Cl)C=C3O)[C@@H1](O)C4=CC=CC=C4Cl CCN(CCO)C(=O)[C@H1]1CCCN(S(=O)(=O)C2=CC=C(C(=O)O)C=C2F)CC1 CCN(CC1(O)CCC1)C(=O)C[C@@H1](C)NC(=O)[C@H1]2C[C@@H1]2C3CCC3 CC(C)(C)C1=NC(C(=O)N[C@@H1]2[C@H1]3CCN(C(=O)C4=CC=C(CCF)C=C4)[C@H1]32)=CO1 C#CC[C@H1](O)C(=O)NCCN(CC)C(=O)[C@@H1]1C[C@H1]1C2CC2 CC[C@@H1](SC1=CC=CC=C1)C(=O)NC2=C(F)C(F)=C(F)C(F)=C2I CC(C(=O)N(C)C[C@@H1]1CCCN(C(=O)C=2C=CSC=2Cl)C1)=C3CCCC3 CC(=O)[C@H1](C)C[C@H1](C)C(=O)N1CCCC[C@@H1]1CC(=O)N2CC(CN=[N+1]=[N-1])C2 COC1=CC=C([C@H1]2[C@@H1](C(=O)NNC3=CC(C(=O)O)=CC=C3I)CCC(=O)N2C)C=C1 C[C@@H1](C(=O)N1CC[C@H1]2[C@@H1]1CCCN2C(=O)C3=NN=C(O)N=C3O)C=4C=NN(C)C=4 CN(C(=O)CCC1=NC2=CN=CC=C2[NH1]1)[C@H1](CNC(=O)[C@H1]3CCOC3)C4CC4 C=CCCCCCC(=O)NC1CCN(C(=O)C2=CC=CC=3C=CSC2=3)CC1 C=CCC1(C(=O)N2CCC[C@@H1](CCNC(=O)[C@@H1]3C[C@H1]4CC[C@H1]3O4)C2)CCC1 N#CC1=CC=C(CN2C[C@@H1](F)C[C@@H1](C(=O)NC3=CC=NN4C=CN=C34)C2)C(Br)=C1 CCC=1C=C(C(=O)N2C[C@@H1](C)N(C(=O)COC(C)(C)CC)C[C@H1]2C)OC=1CC COCCNC(=O)C(=O)NC[C@@]1(F)CCN(C(=O)C2(NC3=CC=CC=C3)CC2)C1 O=C1NCCC[C@@H1]1CC(=O)N2CC[C@@H1]3C[C@]3(C(=O)N4C[C@@H1](O)CCO4)CC2 CCCC[C@@H1](C)COC(=O)[C@@H1](CC1=CC=C(C)C=C1)N(C)C CCC[C@@H1](CNC(=O)C1=CC(C)=CC(O)=N1)C(=O)NC2=CC=C(F)C=C2F CC1=CC(Cl)=C(C(=O)N2CCC3(CC2)CN(C(=O)COCCF)CCO3)C=N1 CC=1N=C(Br)SC=1[C@@H1](C(=O)NCC2=CC=CS2)N3CCC[C@@]4(COC(C)(C)C4)C3 COC1=CC(CCC(=O)NC[C@H1](C)NC(=O)C23CCCN2CCC3)=CC=C1F CCC1=CC=CC(C(=O)N2CC[C@@H1]3C[C@@]32C(=O)N4CC(=O)NC(C)(C)C4)=N1 CCC=1N=CSC=1C(=O)N2CCN(C(=O)C[C@H1](C)C3=CC=NC=C3)C4(CCC4)C2 CCC[C@H1](CC1CCCC1)C(=O)N2C[C@@H1]3C[C@H1]2[C@@H1]3CNC(=O)C[C@@H1](C)C(C)(C)C C[C@@H1](CF)C(=O)N1C[C@@H1](NC(=O)C2(C3=CC=C(Cl)C=C3)CC2)C(C)(C)C1 CCC1=CC=C([C@@H1]2CN(C(=O)[C@@H1](F)OC)CCN2C(=O)CC3(C(F)F)CC3)C=C1 CN(C)[C@]1(C)CCN(C(=O)[C@@H1](NC(=O)CCC2=CC=CO2)[C@@H1]3CC=CCC3)C1 CCC1=CC=C(NC(=O)[C@H1](NC(=O)C2=CC=CN=C2S)[C@@H1]3CC=CCC3)C(C)=C1 CN(C)S(=O)(=O)CCC(=O)N[C@@H1]1C[C@H1]2C[C@H1](NC(=O)C3=CSC(Cl)=N3)C[C@H1]2C1 CC1=CC=C2N=C(C(=O)N3CCC[C@@H1](NC(=O)C4=C[NH1]C=C4C)[C@H1]3C)C=CC2=C1 CCC[C@H1]1CC[C@H1](C(=O)NC[C@@H1]2C[C@H1]2CNC(=O)[C@@H1](O)CN3CCCC3)CC1 CCOCC(=O)N[C@@H1]1C[C@]12CCN(C(=O)[C@H1](C)CC)C2 C[C@](O)(CNC(=O)C1=CSN=N1)[C@@H1]2CCCN(C(=O)COC3CCCC3)C2 CC(C)(O)C(F)(F)C(=O)N1C[C@@H1]2CCC[C@]2(CNC(=O)C=3C=NN4C=CSC=34)C1 CCSCC(=O)N1CCOC[C@H1]1CN(C)C(=O)C2=CC=CC3=C2C=CN3C CCC1=CN=C(C(=O)N[C@H1](C)[C@@H1]2CCCN2C(=O)C=3C=C(C)N(C)C(=O)C=3)C=N1 CS(=O)(=O)C1(C(=O)NC[C@H1](CO)CNC(=O)[C@@H1]2C[C@@H1]3CC[C@H1]2O3)CCC1 CC1=C(C(=O)N2CCN(C(=O)C3=CC=CC(C4COC4)=C3)[C@@H1]5C[C@H1]52)CCS1(=O)=O C[C@@H1]1CN(C(=O)CC2CN(C(=O)CCNC(=O)OC(C)(C)C)C2)C[C@@H1](C)C1O CC=1SC(=O)N(CCC(=O)NC2CCN(C(=O)CCCN(C)C)CC2)C=1C C=C(CCNC(=O)C1=CC=CC=C1CC#N)CNC(=O)C=2C=NC3=CC=NN3C=2 O=C(NC[C@H1]1CCCN1C(=O)CC2=CC=NO2)C3=CC=C(N4CCOCC4)N=C3 CC1=CC=CC(C2=CSC(=NCC3=CC=CC(C(=O)O)=C3F)[NH1]2)=C1C O=C(NC[C@H1]1CCC2(CN(C(=O)C=C(Cl)Cl)C2)O1)[C@H1]3CCS(=O)(=O)N3 CCC1(O)CCN([C@H1](C(=O)NCC=2N=NN(C)N=2)C3=CSC(C(C)C)=N3)CC1 CC1(CC(=O)NC2=CC([N+1](=O)[O-1])=CC=C2I)CN(C(=O)C3=CC=C(Br)N=C3Br)C1 COCC1(C(=O)N2C[C@@H1]3C[C@H1](C2)[C@H1](NC(=O)C(N)=O)C3)CCC1 CCCN1N=CC=C1C(=O)NCCN(C)C(=O)C=2SC3=NC=CN=C3C=2NC COC(=O)CCCC(=O)N1CCCC2(CC(NC(=O)[C@H1](F)C3(O)CCCC3)C2)C1 CN(C)[C@H1](CO)C(=O)NCC1(NC(=O)C[C@](O)(C2=CC=CC=C2)C3CC3)CC1 COCC(=O)N(C)C[C@@]1(O)CCN(C(=O)C=2C=C(C(=O)OC)ON=2)C1 CC=1SC=NC=1C(=O)N2CCC(CN(C)C(=O)C3=CC(C4CC4)=NN3C)CC2 CC=1[NH1]C(C)=C(C(=O)NCC[C@H1](O)CNC(=O)CN2C=CC(=O)C=C2C)C=1C COC(=O)C1=CC=C(NC(=O)[C@H1]([C@@H1]2C[C@H1]3C=C[C@H1]2C3)N4C[C@@H1]5C[C@H1]5C4)C=C1 COC1=CC=C(C(=O)NC(C)(C)[C@H1](C)CC(=O)N[C@H1](C)C2=CC=C(O)N=C2)N=N1 COC1=CC(NC(=O)C2=CC(Cl)=NC=C2NCC3=CN=C(C)N=C3)=C(Cl)C=N1 CCC[C@H1](CCCNC(=O)CC1=CC=CC(F)=C1)NC(=O)C(F)=C2CCCC2 COCCC1=CN=C(NC(=O)N[C@@H1]2C[C@H1]3C[C@H1]2C[C@H1]3O)S1 CN(CC1CN(C(=O)[C@H1]2CCC(C)(C)O2)C1)C(=O)C3=NN[C@@H1](C(F)(F)F)C3 C[C@@H1]1CC[C@H1](C(=O)NCCC2(NC(=O)C3CCC(C#N)CC3)CCC2)O1 C#CC1=CC=CC=C1CC(=O)N[C@@H1]2C[C@@H1]3CN(C(=O)[C@@H1](SC)C4=CC=CS4)C[C@H1]32 CCC1=NC2=C(C(=O)NC[C@H1](CNC(=O)CC3CCOCC3)[C@@H1]2C(F)(F)F)[NH1]1 CC1=CC=NC2=C(C(=O)N[C@H1](C)CC[C@@H1]3CCCO3)C=NN12 CCN1N=C(C(=O)N[C@H1](C(C)C)[C@H1](C)NC(=O)C=2[NH1]C(C)=C(C)C=2C)C=CC1=O CCC(=O)NCC(=O)N(C)CC(C)(C)NC(=O)CN1CCCC2(CC2)S1(=O)=O CCC1=NC(C(=O)NCCC[C@H1](C)NC(=O)[C@@H1](C)CC2=CC=CC(F)=C2)=CO1 CC=1C=CSC=1C(=O)N[C@H1](CO)CNC(=O)/C=C/C2=CC=C(CC(C)C)C=C2 CC1=CC=C(C(=O)NC[C@@H1]2C[C@H1]3CC[C@H1]2N(C(=O)C4=CC=C(F)N=C4F)C3)[NH1]1 CC(C)(NC(=O)[C@H1](O)C1CCC1)[C@@H1]2CCCN2C(=O)C3=CC=C4C(=N3)CCC4 C=CC[C@@]1(C(=O)N2CC3=CC=NC=C3C2)CCN(C(=O)[C@H1]4CCOC4)C1 CCC1=C[NH1]N=C1C(=O)N[C@@H1]2C[C@H1]3C[C@H1](NC(=O)C[C@H1]4C=CCC4)C[C@H1]3C2 CN(C)C1=CC=C(N[C@@H1](C=2SC=NC=2Br)C3=NN=NN3C)C(F)=C1 CC1=CC=C(Br)C(CN(C)C(=O)C=2C=CSC=2S(N)(=O)=O)=C1 CCCC[C@H1](CNC(=O)[C@@H1]1CO[C@H1]2COC[C@@H1]12)NC(=O)[C@@H1]3C[C@@H1]4C=C[C@H1]3CC4 CC(C)(C)N1C=C(Cl)C(C(=O)N2CCN(C(=O)C=C3CN4CCC3CC4)CC2)=N1 CC=1N=C(C)N(CC(=O)N2C[C@H1](C)[C@@H1](NC(=O)CC3(O)CCCC3)C2)N=1 CC[C@](C)(CNC(=O)C1=CN2C(=N1)CCC[C@@H1]2C)NC(=O)C3CCC(C)(C)CC3 C=CCN(CCO)C(=O)C12CCC(CC1)N(C(=O)CC3(C)CCCCC3)C2 CO[C@H1](CNC1=NC(N(C)CCCOCC2=CC=CC=C2)=NC=3SC=NC1=3)C4CC4 C=CCCN=C(NC[C@@H1]1CCCN(C(C)=O)C1)NC[C@@H1]2CCCCO2 CN(CCCNC(=O)N[C@H1]1CCC(C)(C)C2=NC=CC=C21)CCC(=O)O C[C@@H1](OCC1=CC=NC=C1)C(=O)N2C[C@@H1](F)C[C@H1]2CNC(=O)C3=CN=CO3 O=C(NC[C@H1]1C[C@H1](CN2C=C(CC3(CO)CCC3)N=N2)C1)C=4C=CN(CCF)N=4 C[C@@H1](CC(=O)NC1(C2CN(C(=O)[C@H1](C)CC3CCCC3)C2)CC1)C(F)(F)F COC1(OC)CC(C(=O)NC2=CC(C(F)(F)F)=CS2)C1 CC1=CC(C)=C(CN2C[C@@H1]3[C@H1](C(=O)NC4=C(Br)C=C(Br)C=C4Br)[C@@H1]3C2)C(C)=C1 CC=1C=C(CNC(=O)[C@@H1]2COC[C@H1]2C(N)=O)OC=1C(=O)NCC3=CC=C(F)N=C3 CC1=NC=C(NC(=O)C2CC3(CC(NCC4=CC=NN4C(C)(C)C)C3)C2)C(C)=N1 CCC1=CC=C(C(=O)N2C[C@@H1](NC(=O)C=3C=CC(=N)[NH1]C=3Cl)[C@H1](C)C2)[NH1]1 C[C@H1]1C[C@H1](CNC(=O)C2=CC(N(C)C)=CC=C2)CN1C(=O)[C@@H1]3CCC[C@H1](O)C3 CC(C)(C(N)=O)C(=O)N[C@@H1]1C[C@@H1](NC(=O)C2CCC3(CC2)CC3(F)F)C[C@H1]1O CC1=NO[C@@H1](C(=O)NCC[C@H1](C)N(C)C(=O)C23CC(CC(F)C)(C2)C3)C1 CC(C)S(=O)(=O)CC(=O)N1C[C@@H1]2C[C@@H1](NC(=O)C[C@@H1](C)C(C)C)[C@H1]1C2 C[C@H1](O)CC(=O)N[C@H1](C)CN1CCN(C(=O)C=CC2=CN=C[NH1]2)CC1 C=C[C@H1](CC)CC(=O)N1CCO[C@@H1](CC(=O)N[C@@H1](CO)C2=CN=CN2C)C1 CO[C@@H1]1CCCC[C@H1]1OC(=O)C2=NN(C3=CN=CC4=NC=CN34)C5=C2CCC5 CCN=C(NCC1=C(C)OCCS1(=O)=O)N2CC[C@H1](CC3=CC=NC=C3)C2 C[C@@H1]1CN(C(=O)C2=CN(CCN3CCOCC3)N=N2)CCN1C(=O)[C@H1](O)CF N=C1[NH1]C=C(C(=O)N2CC(F)(F)C[C@@H1]2CNC(=O)[C@H1]3CCC[C@@H1]4CCCN43)O1 C=CCCCC(=O)NC[C@H1](CO)CNC(=O)C1=CC=C(SC)C=C1Cl C[C@@H1](CN=C1[NH1]C(=N)[NH1]C(=NCC2=CC=C(C#N)S2)[NH1]1)N3CCOCC3 O=C(NC12CCC(CC1)N(C(=O)C3=CC(Cl)=C[NH1]3)C2)C4=NN=C5C=CC=CC5=N4 CC[C@@H1](NC1=NC(C)=CS1)C(=O)NC2(CNC(=O)CC=C(C)C)CCCCC2 CCC=1N=N[NH1]C=1C(=O)NC[C@@H1](C2CC2)N(C)C(=O)CC3CC(C4CC4)C3 CO[C@H1](CCNC(=O)C1(F)CC1)CNC(=O)[C@@H1](C)N2C=NC(C#N)=N2 C#CCN(C)C(=O)[C@@H1]1C[C@@H1]1C(=O)NC[C@@H1]2CCCCN2C(=O)CSC3=NN=CS3 CN(C)[C@H1]1C[C@](O)(C(=O)NC2=CC=C(OCCF)C=C2)C1 O=C(NCC1=CC(C2=CC=CC=C2)=N[NH1]1)[C@@]34C[C@H1]3CN(CCC5=C(Cl)C=CC=C5Cl)C4 CC(C)CCONC(=O)C[C@H1]1CCC[C@@H1](NC(=O)[C@@H1](F)CCC(C)C)C1 CC1=CN2C=CN=C(C(=O)NC[C@H1]3CCCC[C@@H1]3NS(C)(=O)=O)C2=N1 CCCC1=NC(C(=O)N2CC[C@H1](CC(=O)NC[C@H1](O)C3CC3)C2(C)C)=CO1 CCCOCC(=O)N1CCCC[C@@H1]1C(C)(C)CNC(=O)[C@]2(C)CC=CCC2 O=C(C=1SC=CC=1Cl)N2CC[C@H1]3[C@H1](CCCN3C(=O)COCCF)C2 CCN(C[C@@H1]1CCCN1C(=O)COC)C(=O)CN2N=NC3=C2CCCC3 CCN(C)CC(=O)NCCCC(C)(C)NC(=O)C1=CC=CC=2OC(O)=NC1=2 C=CCN1C=C(C(=O)N2CC[C@H1](C(=O)NCC3=CC=C(CC)C=C3)[C@H1]2C(C)C)C=N1 CC1=CC2=C(C=C1C(=O)N3CC[C@H1]([C@H1]4OCC4(F)F)C3)OCO2 CSC(C)(C)CC(=O)N1CC[C@H1](NC(=O)[C@H1](C)[C@H1]2CCOC2)[C@H1](C(N)=O)C1 CC1=CSC(C(=O)N[C@@H1]2COC3(C2)CN(C(=O)C4=CC=CC5=C4OCCN5)C3)=C1 C[C@H1](O)C(F)(F)C(=O)NCC1=NC(CNC(=O)C=2N=CN(C)N=2)=CS1 C=CCC1(C(=O)N[C@@H1](CO)CNC(=O)C2(CC)CCC(F)(F)CC2)CC1 CCN1CC[C@H1](N(C)C(=O)NNC2=NC=NC=3[NH1]C=NC2=3)[C@H1](C)C1 C#CC1=CC=CC(C(=O)N2CCC[C@](CC)(NC(=O)[C@H1](C#N)CCC)C2)=C1 C#CC[C@](C)(NC(=O)[C@@H1]1CCC[C@H1](C)C1)C(=O)N2C[C@H1](C)CC2(C)C C#CCOCCNC(=O)C1CC2(CC(N=C3[NH1]C=NC=4C=NN(C)C3=4)C2)C1 CC=1[NH1]N=C(C(=O)N2CCC3(CC(NC(=O)CC[C@H1]4CC4(Cl)Cl)C3)C2)C=1Cl O=C(C1=C(F)C=C(F)C(O)=C1F)N2CCN(C[C@@H1]3CCC4=NC=NN43)CC2 CC=1SC=C(C(=O)NC[C@@H1](CC(C)C)NC(=O)C(=O)N2CCC[C@H1](C)C2)C=1N C[C@H1]1CC(C(=O)NCCN(C(=O)C2(C)CC(=O)C2)C3CCCCCC3)=NO1 COCCN1N=NN=C1[C@]2(N[C@@H1]3C=CCC3(C)C)C[C@@H1]4CS(=O)(=O)C[C@H1]4C2 CC(C)N(C(=O)CN[C@@H1](CNC(=O)OC(C)(C)C)C1CC1)C2CCCC2 CN(C)[C@@H1](CO)C(=O)N(CCNC(=O)C1=CC2=CC=CC=C2[NH1]C1=N)CC3CC3 CC1(C)C[C@@H1](C(=O)NN2C=NC3=CC=CC=C32)CCN1C(=O)C4CS(=O)C4 C=C[C@](C)(O)C(=O)N1CCC2(CCC(NC(=O)[C@@H1]3CCC[C@H1]3O)CC2)CC1 CC1=CC(F)=CC(C(=O)N[C@H1]2CN(C(=O)CCC3=CC=CN=C3)C[C@@H1]2F)=C1 CCN1C=NC(C(=O)N2C[C@@H1](C)[C@@H1](NC(=O)CC3=CC=C(O)C=C3)C2)=N1 CCCC[C@H1](O)C(=O)N(C)CC1CN(C(=O)C[C@@H1](O)C2CCCC2)C1 O=C(CNC1=NC=CC=N1)NCCC2CN(C(=O)C3=CC=CN4C(O)=NN=C34)C2 CCN(C)CC1=CN(C2CCN(C(=O)C[C@@]3(O)CCCN(C)C3)CC2)N=N1 CC(C)(C)C(=O)N1CCOC[C@]12COCCN(C(=O)C3=CC=CC(F)=C3)C2 CC(C)C1=C(C(=O)NC[C@H1]2C[C@H1]2NC(=O)[C@H1]3CCC(=O)N3)C=NN1C CC1=C(CNC(=O)[C@@H1](C)CNC(=O)[C@@H1]2C[C@H1]2OC(C)=O)N=NN1C CC[C@@H1](CNC(=O)CCOCC(C)(C)C)NC(=O)CC1=C(Br)C=NN1C C[C@@H1](NC(=O)[C@@H1]1[C@H1]2C[C@H1]2CN1C(=O)C3=CC=CC=C3Cl)C4=CN=CC=N4 CCCN=C(NC[C@@H1](CO)C1=CC=CC(F)=C1)NC2CCN(C(=O)OC)CC2 O=C1C[C@]2(C(=O)N3CC(O)(CNC(=O)C(F)=C4CCCC4)C3)CCCC[C@@H1]2N1 C[C@H1](NC(=O)CCOC1CCC1)C2CN(C(=O)[C@H1]3CCCC(=O)N3)C2 CCOC1=CC=C(C(=O)N2CC[C@H1]2CNC(=O)C3(COC)CCCCC3)C=N1 CC(=O)NC1=CC(F)=CC=C1C(=O)N[C@H1]2CCC[C@@H1](NC(=O)COCC3CC3)C2 CCN1N=C(C)C(C(=O)NC2CC3(CC(NC(=O)COCCF)C3)C2)=C1C CCCCC[C@@H1](CC)C(=O)NC1(CN(C)C(=O)C2=NC=NC=C2Cl)CC1 CCO[C@@H1](C#N)CNC1=CC=C(S(=O)(=O)N[C@H1]2CC2(C)C)C(Cl)=C1 CC(C)(C)OC(=O)N1CC[C@@H1](CNC2(C3CCSCC3)CCCC2)C(F)(F)C1 CC=CC(=O)N1CC[C@@H1](C)[C@@H1](CC(=O)NCC2=CC(C)=CC=C2Br)C1 C[C@]1(CNC(=O)[C@@H1]2CCCC[C@@H1]2O)CN(CCN3C(=O)CCC3=O)CCO1 O=C(C1=CC=C2[NH1]C=CC2=C1OC(F)F)N3CC4(CCSCC4)C3 COC(=O)NCCC(=O)NC1(CCNC(=O)[C@H1]2CC[C@H1](OC)CC2)CC1 CC(C)CCC(=O)N[C@@H1]1CCN(C(=O)C[C@]23CCC[C@@H1]2C3)C1(C)C CC=1C=NN(CC(=O)N2CC(O)(CN(C)C(=O)C3=CC=C(C)N=C3O)C2)C(=O)C=1 CCC1=CON=C1C(=O)NC[C@H1](NC(=O)C2=CC(P(C)(C)=O)=CS2)[C@H1](C)C(C)C CN1N=C(C(=O)N[C@@H1](CC2=CC=CO2)C(=O)NCCCC=3C=NN(C)C=3)C=C1Cl COCO[C@@H1](C)C(=O)N1CC([C@H1](O)C(=O)NC[C@@H1]2NC(=O)CC2(C)C)C1 CC1(C)CCC[C@@H1](C(=O)N2CCC[C@H1](CNC(=O)C/C=C/C3=CC=CC=C3)C2)C1 CC(C)(C)CC(=O)COC(=O)[C@@H1](F)C1=CC=C(I)C=C1 O=C(N[C@@H1]1[C@H1]2C[C@@H1]3[C@H1]1[C@@H1]3[C@@H1]2C(=O)N4CCC[C@H1](CCO)CC4)C5=CC=CC=C5F CC1=NC=C(C(=O)N2C[C@@H1](NC(=O)C(C)(C)CC(C)C)CC23CCC3)C(C)=N1 CC[C@@H1](C[C@@H1](C)O)NS(=O)(=O)C1=CC=C(NC2CCC3(CCCC3)CC2)C=C1Cl CC1=CC=C(S(C)(=O)=O)C=C1C(=O)NC2(CNC(=O)C=3SC=NC=3C)CCC2 CSSCC(=O)N1CCCC[C@H1]1[C@H1]2CCN(C(=O)C=3C=C(C(C)C)ON=3)C2 COC=1C=CSC=1C(=O)N(CCNC(=O)C[C@@H1]2CCCSC2)C(C)C CC=1[NH1]C(C)=C(C(=O)NC[C@H1](C)N(C)C(=O)CO[C@@H1]2CCC[C@H1](C)C2)C=1C O=C(N[C@@H1]1CN(C(=O)C2=CC(Cl)=N[NH1]2)CC13CC3)C4=CN5C=CC=C(F)C5=N4 CN(CC[C@@H1]1CCCCN1C(=O)C(N)=O)C(=O)C2=CC=C(C3CC3)C=C2 COCC1(C(=O)N[C@@H1]2CCC[C@@H1]3CN(C(=O)C[C@H1]4COC5CC4C5)C[C@@H1]32)CCC1 COC(=S)NC1CC[C@H1](NC(=O)NC=CC=CC[S@](=O)C)C1 CC[C@@H1](CN(CC)C(=O)C1=COC(O)=N1)NC(=O)[C@H1](F)[C@H1](C)CC(C)(C)C C[C@@H1](OCCN(C)C)C(=O)NC[C@]1(O)CCN(C(=O)CCC=2C=CSC=2)C1 CCCCN([C@H1](C)C(=O)OC)[C@@H1](C(=O)NCCC#N)C1=CN=C(CC)N=C1 COCCOC1=CC=C(C#N)C=C1NCC(=O)NCCCC(C)C C[C@@H1](CC(F)(F)F)C(=O)NC[C@H1]1COC[C@H1]1NC(=O)C2(O)CCOCC2 C[C@@H1](C(=O)N1CC[C@@H1](N(C)C(=O)C2=CC=C(C3CC3)C=C2)C1)S(N)(=O)=O CO[C@@H1]1CN(C(=O)C2=CC=C(C)N=C2N)C[C@H1]1NC(=O)C3=NC=CC4=N[NH1]C=C34 C[C@@H1](NC(=O)[C@H1]1CC[C@H1](C2CC2)C1)C(=O)NC3(CO)CCC3 CC(=CC(=O)N1[C@H1]2CC[C@@H1]1C[C@@H1]2NC(=O)CN3C[C@H1]4CC[C@H1]3C4)C5CCCCC5 C[C@](O)(CC(=O)N1CC=C(CNC(=O)[C@H1]2CCCC3=NN=CN32)CC1)C(F)(F)F O=C(C=CC1CCCC1)N[C@H1](CNC(=O)C2=NC=CC=C2C(F)F)[C@H1]3CCOC3 CCC(C)(C)NC(=O)[C@@H1](C1=CN=CC=N1)N(C)CC2(COC)CCOCC2 CCC1=CC(C(=O)N(C)[C@H1](CNC(=O)C2=CC(Cl)=NS2)C3CC3)=C(C)N=N1 COC1=CC=C(C(=O)NCC2=CCCN(C(=O)C3=C(C)OCCC3)C2)C=C1OC C[C@](CO)(CS(C)(=O)=O)NCC1=C[NH1]N=C1C2=CC=CC(F)=C2 N=C1N=C2C=C(C(=O)NCC[C@@H1]3CCCN(C(=O)C4=CN=C(S)[NH1]4)C3)C=CN2[NH1]1 CC1=CC(C(=O)NC2CC(N(C)C(=O)C=3C=NSC=3C)C2)=CC=C1Br CCN1CCO[C@H1](CN=C2C=CN=C(NC[C@@H1]3CN(C4CC4)C(=O)O3)[NH1]2)C1 C=CC[C@H1](CC(F)F)C(=O)N[C@@H1](C)C1CCN(C(=O)[C@@H1]2CCC(=O)N(C)C2)CC1 C=C1CC[C@@H1]1C(=O)N2C[C@@H1](NC(=O)[C@H1](O)C3=CC=CC=C3)C[C@H1]2C COC1=CC(C(=O)N2CC[C@@H1](CNC(=O)CC3CC4(CC4)C3)C2)=C(F)C=C1N CCC[C@@H1](OC)C(=O)N1CC(SC)(C(=O)NCCC2=C[NH1]N=C2C)C1 CN1CCC[C@@H1](CC2=NC(C(C)(C)C(=O)O)=NO2)C1 CC(=O)NC1=NC=C(C(=O)NC[C@]2(F)C[C@@H1](CNC(=O)[C@@H1]3CC(C)(C)O3)C2)O1 O=C(C1=CC=CS1)N2CC[C@@]3(CCCN(CC4=C(Cl)C=CN=C4Br)C3)C2 CC(C)(CNC(=O)[C@H1](F)C1=CC=CC=C1F)NC(=O)C=2C=CSC=2C#N COCC1=CN=CC(C(=O)NCCNC(=O)[C@@](C)(O)C2=CC=CC=N2)=C1 CC=1C=CC(=O)N(CC(=O)N(CCN(C)C)CC2=CC=C(F)C=C2)C=1 CO[C@@H1](CNC(=O)C1=NC=CC2=NC=CC=C12)CNC(=O)C3=CC=C[NH1]3 CC[C@@](C)(F)C(=O)N1CCCC[C@H1](CNC(=O)C=2N=CN3C=2CCCC3)C1 CC(C)CC[C@@H1](O)C(=O)N[C@H1](C(=O)N1CCCC2=CC=CC=C21)C3=CC=CO3 CCC[C@H1](O)CC(=O)N1[C@H1]2CCC[C@H1]1CN(C(=O)C3=CC(C)=CC(O)=N3)C2 CN1N=C(C(=O)NC[C@H1]2CCN2CCC3=CC=C(Cl)C=C3)C=C1Cl C[C@H1](CN(C)C(=O)C1=CC=C(N=[N+1]=[N-1])C=C1)NC(=O)C2=CC=CC([N+1](=O)[O-1])=C2O O=C(C=1C=CN(C2=CN=CC(F)=C2)N=1)N3CC[C@@H1](N4C=CC=N4)C3 CC(C)CO[C@@H1](C)C(=O)N1C[C@H1]2CCC[C@@](NC(=O)CCCCNC(N)=O)(C2)C1 CCC(=CC(=O)NCC#CCNC(=O)CC1=CC=CC2=C1SCCC2)CC O=C(C1=CC=NN1CC(F)F)N2C[C@@H1]3CCCN(C(=O)[C@H1](F)C4CCC4)[C@@H1]3C2 CC(C)C1=NC=C(C(=O)NCC(C)(C)CNC(=O)[C@H1]2CN(C)CCN2C)C=N1 CCC1=CN=CC([C@@H1](C(=O)NCCC#N)N(C)[C@@H1](C)C2=CC=NC=C2)=C1 C=CCCCCCCCC(=O)NC[C@H1]1CN(C(=O)[C@@]23C[C@@H1](F)[C@@H1]2C3)C(C)(C)C1 CC1=NC=C(C=CC(=O)N2CCC[C@H1]2CN(C(=O)[C@@]34COC[C@@H1]3C4)C5CC5)S1 CCC1=CC=C(N2C=C([C@@H1](CC(N)=O)NC(=O)C3=CC(F)=C[NH1]3)N=N2)C=C1 CSC1=NC(N2CC[C@H1](O)[C@H1](C(=O)NCCCCCO)C2)=NC=C1C C[C@@H1]1CN(C(=O)C2CC(F)C2)C[C@H1]1CNC(=O)CC3=CSC(Cl)=N3 C[C@H1](CC=1N=C[NH1]N=1)NC(=O)[C@@H1]2CCN(C(=O)C(C)(C)N3C=CC=N3)C2 CN(C(=O)C1=CC=CN=C1N2C=C(Br)C=N2)[C@@H1]3CCN(C(=O)C#CC4CC4)C3 CCC[C@H1](O)C(=O)N[C@@H1](C)[C@@H1]1CCCN(S(=O)(=O)C2=CC=C(Br)C(OC)=C2)C1 O=C([C@H1]1CC2=CC=CC=C2O1)N3CC[C@@H1]4CCN(C(=O)CCCC5CCC5)[C@@H1]4C3 CCO[C@@H1]1CCC[C@@H1](NC2=CN=C(C3=CC=CC=C3CC)N=C2)C1 CC1=CC(=NCCC(F)(F)F)[NH1]C(N2CCOC[C@@H1](C)C2)=N1 CCCSCCC(=O)N(C)CCNC(=O)C1=CC=CC(N2CCOCC2)=N1 O=C(CSC1CC1)NCCOCCCNC(=O)C[C@@H1]2COC3=CC=CC=C3O2 CC(C)(C(N)=O)C(=O)NCC1=CC=C(C(=O)NC2([C@@H1](O)CO)CC2)O1 C=C1CN(C(=O)C=2C=NN3C=2CN(C(=O)C4=CC=CC([N+1](=O)[O-1])=C4C)CC3)C1 CC[C@H1](C)[C@](C)(O)CNC(=O)CCN(CC)C(=O)C1=NC=NC=C1Cl N#C[C@]1(C(=O)NCCNC(=O)CN2CCOCC2=O)C[C@@H1]3CCC[C@H1]3C1 CCC1=NC(C(=O)N(C)[C@@H1](C)CN(C)C(=O)C=NOC)=CC2=CC=CC=C12 CC[C@@H1](C(=O)N(C)[C@@H1](C)CNC(=O)C1=CC=CN=C1N(C)C)N(CC)CC CCOC(=O)C1=CC(NC(=O)CC2CN(CC=3C=NN(CC)C=3)C2)=CN=C1C CC(C)(CCNC(=O)COC1CCC1)NC(=O)C2=CC(Br)=CC=C2N CCS[C@@H1](C(=O)N1CCC[C@H1]1CN(C)C(=O)C2=C(C)N=CN2OC)C(C)C CCOC1=NC(C(=O)NC(C)(C)CCNC(=O)C(C)(C)C=2C=NSC=2)=CO1 CCS[C@H1](C)C(=O)NC(C)(C)[C@@H1]1CCCN1C(=O)C2=NNC(=O)CC2 C[C@@H1]1CN(C(=O)C2=CC=C(OCC(F)F)C=C2)CCCN1C(=O)[C@@H1]3CC[C@@H1](O)C3 C=C[C@H1](C)CC(=O)NC[C@@H1]1CN(C(=O)CCC=2SC=NC=2C)CC13CC3 CO[C@H1]1CC[C@H1](C(=O)N(C)CCCNC(=O)CCC23CCC(CC2)C3)C1 C[C@@H1](O)C(=O)N[C@H1]1CCN(C(=O)C2=CC(Br)=C3[NH1]N=NC3=C2)C14CCC4 CC=1OC(C(C)C)=NC=1C(=O)N2CCCC[C@@H1](NC(=O)[C@@H1]3CCC[C@H1](CF)C3)C2 CCCN(CCNC(=O)[C@]1(C)CCCS1(=O)=O)C(=O)CN(C)[C@H1]2CCSC2 CCCCCC(=O)N[C@H1]1C[C@@H1](OCC(=O)NCC=2OC=NC=2CC)C1 C#CCC1(C(=O)NC[C@H1]2CCC3(CN(C(=O)CC4=CSC(S)=N4)C3)O2)CC1 CS(C)(=O)=NC(=O)C(=O)NCC1(O)CC(NC(=O)CC[C@@H1]2CCCC(=O)N2)C1 CC1=CC(=N[C@H1]2C[C@H1]3CCCC4=CC=CC2=C43)[NH1]C(N[C@H1]5CCCSC5)=N1 C#CC[C@@H1](NC(=O)CC1=CN=CS1)C(=O)N[C@@H1](C)C(=O)NC2CC2 CC1(C)CCO[C@@H1](CC(=O)N[C@H1]2C[C@H1](NC(=O)C[C@H1]3SC4=NCCN4C3=O)C2)C1 N=C1[NH1]C(SCC(=O)OCC2=CC=CC(I)=C2F)=CN=C1N C=C(CCNC(=O)[C@H1]1CCCC2(CCC2)C1)CNC(=O)[C@@H1](C)C3=CC=CS3 CC(C)N1N=CC=C1C(=O)N2CC[C@@H1](C)N(C(=O)C[C@H1](O)C3=CC=CC=C3)CC2 CC1=CC=C(F)C(C(=O)N[C@H1]2CC[C@H1]2NC(=O)CN3N=CC=N3)=C1Br C[C@H1](CNC(=O)C1(CCF)CCOCC1)N(C)C(=O)C[C@H1]2CCC[C@H1](C#N)C2 CC(C)(C)C1=CN=C(NC(=O)[C@H1]2C[C@H1](F)CN(CC3=CC=NC(Br)=C3Cl)C2)[NH1]1 CC1=NC(C2(NC(=O)C3=CC(CNC(=O)C4(C(F)(F)F)CC4)=CS3)CC2)=NO1 CC[C@@H1](NCC1=CN(C[C@H1]2CCCN2)N=N1)C3=CC=CC(S(=O)(=O)N(C)C)=C3 CO[C@@H1]1CN(C(=O)[C@]2(C)CCCN2C(=O)C3CC4(CC4)C3)C[C@H1]1O CCC(CC)(CNC(=O)C[C@@H1]1CC[C@H1]2C[C@@H1]2C1)N=C3[NH1]C(Cl)=NC4=CC=CC=C34 C[C@@H1](CC1=CC=CC=C1F)C(=O)N2C[C@H1]3CC[C@@](NC(=O)CNS(N)(=O)=O)(C3)C2 CC(C)CC1(C(=O)NCC[C@H1](O)CNC(=O)C2=NC=C(Cl)C=C2Cl)CCCC1 O=C(N[C@H1]1CC[C@H1]2C[C@H1]1CN2C(=O)C3=CSC4=C3CCCC4)C5CCCCCC5 CC(C)(C)[C@@H1](CNC(=O)CC=1C=N[NH1]C=1)C(=O)NCC2=CCCC2 O=C(CCN=C1[NH1]C=CS1)NCC2CN(C(=O)[C@@H1]3[C@H1]4C[C@@H1]4[C@H1]5C[C@@H1]35)C2 C[C@@H1](OCC1CC1)C(=O)NC[C@@H1]2CCN2C(=O)C3=CC(N)=CC(F)=C3 CC1=CC=CC(=C1)S[C@H1]C(=O)N2CC([C@H1](C)NC(=O)CCN3CCCCC3)C2 COC(=O)C1=CC=C(CC(=O)NC[C@@H1](C)NC(=O)C2=CC=3SC=CC=3S2)C=N1 CC(=O)N1CC(C(=O)N(C)CC2CN(C(=O)[C@@H1]3CC[C@H1](F)C3)C2)C1 O=C(N[C@H1]1CCCC[C@@H1]1C(=O)NCC2=CC=C3C(=C2)OCO3)C4CC(F)(F)C4 C[C@H1](C(=O)N1CCC(C2(NC(=O)CCCC#N)CCC2)CC1)[C@@H1]3CCOC3 CC=1SC(C)=C2SC(C(=O)N3CC(N4C=C(C[C@H1](CC)C(=O)O)N=N4)C3)=CC=12 COC(=O)[C@@H1]1CCC[C@@H1]2CN(C(=O)C3=CN=CC(C(C)(C)C)=C3)C[C@@H1]21 CC(C)CCC(=O)N1CC[C@@H1](C)[C@@H1](CNC(=O)COC2=CC=C(Br)C=N2)C1 O=C(NCC=1C=NN(CCO)C=1)NC2=CC=CC=C2CN3CCCCCC3 O=C(N[C@H1]1C[C@@H1]2CC[C@H1](C1)N2C(=O)C=CBr)C=3C=C(C4=CC=NC=C4)ON=3 CC1=CC=C(Cl)C(CN[C@@]2(C3=CC=CC=C3)CCS(=O)(=O)C2)=C1 C=CCCC1=CC=CC=C1[C@@H1](NCC[C@H1]2COCCO2)C3=NN=NN3CC(=C)C CO[C@H1](C(=O)N1CC[C@](O)([C@@H1](C)NC(=O)C2=CN=NC=C2C)C1)C3CCCC3 O=C(NC[C@H1]1CC(F)(F)CN1C2=NC=C(F)C(C(F)(F)F)=N2)C3=CC=C(F)C=C3 C[C@@H1](CN(C)C)C(=O)N(C)C1C[C@@H1]2CC[C@H1](C1)N2C(=O)[C@@]3(C(F)(F)F)CC=CCO3 CCCCC1=NC=C(C(=O)NCC[C@@H1]2CC[C@@H1](NC(=O)CN3N=CN=N3)C2)S1 CC(=O)C1=C[NH1]C(C(=O)NCC2=CC(C(=O)NC[C@](C)(O)C(C)C)=NO2)=C1 CCC1(CC)CC(C(=O)NCC#CCNC(=O)[C@@]2(C)CCCS2)C1 CCO[C@H1](C)C1=NOC(CCC(=O)N[C@H1]2C[C@@H1](NC(=O)C3=CC(C)=NS3)C2)=N1 CC(=O)OC[C@H1](C)C(=O)N1CC[C@]2(NC(=O)C3=C[C@H1]4CC[C@@H1](C3)C4)C[C@@H1]2C1 COC(=O)[C@@H1]1C=CCCN1C(=O)[C@H1]2C[C@H1]3C[C@H1]2CN(C(=O)[C@@H1]4C(C)(C)C4(F)F)C3 NC1=CC=C(F)C(C(=O)N2CC(F)(F)C[C@H1]2CCNC(=O)C3=N[NH1]C=C3Cl)=C1F O=C(NC=1C=NC2=NC=CN2C=1)N(CC3(O)CCOCC3)C4CC4 CC[C@@H1](CN1CCCC1)NC(=O)CC[C@H1]2CCCN2C(=O)C3=CN(C)N=C3C O=C(N[C@H1]1CCN(C(=O)C2=CC=NS2)C1)C=3C=C(C4=CC=CC=C4)ON=3 COC[C@H1]1C[C@@H1](CNC(=O)[C@H1]2C[C@H1](N3C=CN=N3)C2)N(C(=O)[C@@H1](C)NC(C)=O)C1 CN1C=C(C=2C=CC3=NN=C(C(=O)NC4=C(O)C=CC=C4Br)N3C=2)C=CC1=O CC1=CN=C(O)C(CNC(=O)[C@H1]2CCN(C(=O)C[C@@H1]3COC[C@H1]3O)C2(C)C)=C1 CNC1=CN=CC=C1C(=O)NC/C=C/CC(=O)NCC=2C=NN(C(C)C)C=2 CC(C)N(C(=O)C1=CN2C=C(C#N)C=CC2=N1)C3=CC=CC4=CC=CC=C34 CC[C@@H1](CC(=O)N[C@@H1](C)CC(=O)NC)N(C)C(=O)C1=CC(O)=CS1 CN1C[C@@H1](C(=O)NCC2CC(O)(CNC(=O)C3=CC=C(CF)C=C3)C2)CC1=O C[C@@H1](CC(F)(F)F)C(=O)NCC1(O)CC(NC(=O)C=2C=C[NH1]C=2C3CCCC3)C1 CC[C@H1](O)[C@@H1](C)C(=O)N1C[C@@H1]2C[C@H1]1[C@H1]2NC(=O)CCOC C=C(CCNC(=O)C=CC1=CC=C(C#N)C=C1)CNC(=O)[C@@H1](CC)OC CN(C)C(=O)N1CCC[C@@H1](NC(=O)C2=NC3=CN=CN=C3[NH1]C2=O)C1 O=C(NC[C@@H1]1CC2(CO1)CN(C(=O)[C@@H1]3CCC[C@H1](O)C3)C2)C(=O)NCC(F)(F)F CC=1[NH1]C(C#N)=CC=1C(=O)NC[C@]2(C)CC[C@@H1](NC(=O)C3=N[NH1]C=C3[N+1](=O)[O-1])C2 C[C@@]1(C(=O)NCC2(O)CN(C(=O)C34CC(C)(C3)OC45COC5)C2)CCC[C@H1]1O C=C1CC(C(=O)N2C[C@@H1](NC(=O)CC3(C)CCCC3)[C@H1](N4C=CN=N4)C2)C1 CC1=NC(CNC(=O)CONC(=O)C2=CC=CC3=C2CCC3)=N[NH1]1 CCC(CC)OCC(=O)N(CCO)CCC(=O)N1CC[C@H1](N2C=NC=N2)C1 CC(C)[C@H1](NC(=O)C1=CC=CS1)C(=O)O[C@@H1]2CCC3=CC=CC=C3NC2=O CC1=CC=CC(CC(=O)N[C@@H1]2CCN(C(=O)C3=CC=NC=C3)[C@H1]2C4CC4)=C1 CC(C)C(C(=O)N[C@H1]1CCO[C@H1]1C(=O)NC(C)(C)CC(N)=O)C(C)C CC(C)(C)C(C)(C)NC(=O)[C@H1]1CC[C@H1]1CNC(=O)C2=CC=C([N+1](=O)[O-1])O2 CN(CCCC=1C=CON=1)C(=O)[C@@H1]2CCC[C@H1](NC(=O)CCC(C)(C)C)CC2 CN(C(=O)[C@H1]1CCCC[C@@H1]1F)C2CN(C(=O)C=C3CC(C)(C)CC(C)(C)C3)C2 CC(C)N(C)C(=O)[C@@H1]1CCN(C(=O)[C@@H1](C)C2(O)CCC2)CC1(C)C CC1=NN=C2N1C[C@H1](C(=O)N3CC[C@@H1]3CNC(=O)CCC4=CC(Cl)=NO4)C2 CC(C)(C)CCN=C1N=CN=CN(CC(=O)NC2=CC=CC=C2)[NH1]1 C#CC[C@](C)(NC(=O)[C@@H1](C)[C@@H1]1CCC(=O)N1)C(=O)NCC2=NC=C(C)S2 CC(C)C[C@H1](C)C(=O)N[C@@H1](C)C[C@H1](C)NC(=O)CCCN1CCCCC1 CC[C@@](C)(CO)NC(=O)[C@@H1]1[C@H1]2CN(C(=O)[C@@H1]3CCCC(=O)CC3)C[C@H1]21 C[C@H1](CCC(C)(C)C)NC(=O)C(C)(C)C1=CCN(C(=O)[C@@H1]2COC(=O)N2C)C1 CO[C@@H1](C=1N=C(CN2CCC(O)CC2)N(C3=CC=CC=C3C)N=1)C4CC4 O=C(NCCCN(CCO)C(=O)C=1C=COC=1)[C@@H1](O)C2=CC=C(Cl)C=C2 CC1=CC=C(CCC(=O)N2CC[C@@H1](OCCNC(=O)CCC3=CC=C[NH1]3)C2)S1 C#CCOCCC(=O)N[C@H1]1C[C@H1]2CC[C@]1(C(=O)N[C@H1]3CCC[C@H1]3C(C)(C)C)C2 COC1=CC=NC(C(=O)NC(=O)CN2CC[C@@H1](P(C)(C)=O)C2(C)C)=C1 O=C(NCCN(C(=O)CC1=C(F)C=NC=C1Cl)C2CCCC2)[C@@H1]3CC34CC4 C[C@@H1](C(=O)N1CC(F)(F)C[C@]1(C)CNC(=O)C#CC2CCC2)C3=CC=CS3 O=C(COCC1CCCC1)NCCCC[C@@H1]2CCCN(C(=O)C[C@@H1]3C=CCC3)C2 C#C[C@H1]1[C@H1](C(=O)N2CCC3(CN(C(=O)C4=CC([N+1](=O)[O-1])=C[NH1]4)C3)C2)C1(C)C CCC1=CN=C(C(=O)NC[C@@]2(C3CC3)CCN(C(=O)[C@H1]4C[C@H1](C#N)C4)C2)C=N1 CC[C@@H1](CC(F)(F)F)NC(=O)[C@@](F)(CNC(=O)C1CCCC1)C(C)C CC(=O)N(C)CC(=O)N1C[C@@H1]2C[C@H1]1[C@H1](N(C)C(=O)CCN3N=CN(C)C3=O)C2 CC(C)[C@@H1]1[C@@H1](NC(=O)CC2=CN=CN=C2O)CCN1C(=O)[C@@H1]3CCC[C@H1]3C CN1N=CC=C1C(=O)N[C@@H1]2CCCC[C@@H1]2CNC(=O)C(=O)NC3CC3 C=C(C)C[C@H1](OC)C(=O)N(C)C/C=C/C(=O)NC[C@H1](C)S(C)(=O)=O CCN1CC[C@@H1]1C(=O)N[C@@H1]2CN(C(=O)CCC(=O)C3=CC=C(Cl)C=N3)CC2(C)C C[C@@H1](C(=O)N(O)CC1=CN(C2CCOCC2)N=N1)[C@@H1]3CCOC3 CC1=NC(C(=O)N2CCO[C@@H1](CN(C)C(=O)C(C)(C)NS(C)(=O)=O)C2)=NN1C CC[C@@H1]1[C@H1](NC(=O)[C@H1]2CCO[C@@H1]2C)CCCN1C(=O)C3=CC=C(O)N=C3C CCCC[C@@H1](C)CCC(=O)N[C@@]1(C)CCN(C(=O)CCC2CCOCC2)C1 C[C@H1]1OCCC[C@H1]1C(=O)N2CCC(CCNC(=O)C3(C#N)CC(=O)C3)CC2 C=C=C[C@H1](C)C(=O)NC(C)(C)[C@@H1]1CCN(C(=O)CCCC(C)=O)C1 C[C@]1(CO)CCCN(C(=O)NCC2=CC=C(Br)C(C(F)(F)F)=C2)C1 C[C@@H1]1[C@H1](C(=O)N(C)CCCO)CCCN1C(=O)C[C@H1]2CNC(=O)O2 CC(=O)O[C@H1](C(=O)N1CC[C@@H1](C2=CN(CC(C)(C)O)N=N2)C1)C3=CC=CC=C3F C[C@@H1](CNC(=O)C1CC(=C(F)F)C1)NC(=O)C2=C(N)C=CC=C2[N+1](=O)[O-1] CN1CC2(CC2)C[C@H1]1C(=O)N3C[C@@H1]4C[C@H1]3CN4C(=O)CN5CCC(CO)CC5 CCCOC1=CC=C(C(=O)N2CC=C[C@@H1]2CNC(=O)[C@@H1]3CC(C4CC4)=NO3)C=C1 CCCC1CC(C(=O)N2CC3(CN(C(=O)CN4C=NC=N4)C[C@@H1]3CO)C2)C1 CCCCC[C@H1](F)C(=O)N1CC[C@@H1]2CCC[C@@]21C(=O)NCCCN3C=NC=N3 CCCC1=NC(C)=C(C(=O)OCCN2C=C(Br)C=N2)S1 C[C@@H1]1C[C@H1](NC(=O)C2=CN=C3C=CSC3=C2)CN1C(=O)C(=O)NCC(F)(F)F CCN(CC)C[C@H1](F)C(=O)NCC1=CN(CCNC(=O)[C@@H1]2C[C@@H1]3CC[C@H1]2O3)N=N1 CC1=CC=CC(NC(=O)N2CCC[C@H1]3[C@@H1]2CCN3C(=O)C4=CC(C)=C(Br)C=N4)=C1 CN(CCOCCNC(=O)CCCCN1CCOCC1)C(=O)[C@@]2(O)CCSC2 CC1=NC(O)=CC(N(C)[C@H1](C)CNC(=O)C2=CC(C3=CC=CC=C3)=CC=N2)=N1 CN(CC1(NC(=O)C2=CC=CC=3N=C[NH1]C2=3)CC1)C(=O)[C@H1]4CCN5N=NN=C5C4 NC(=O)CNS(=O)(=O)C1=CC=C(C(=O)NC[C@H1]2C[C@H1](NC(=O)C3(O)CC3)C2)O1 CP(C)(=O)C1=CN=CC(C(=O)N2CC[C@@H1](NC(=O)C3=CC(Cl)=C[NH1]3)C24CC4)=C1 CN1CC(C(=O)N[C@@H1]2CCN(C(=O)COCC(F)F)[C@@H1]2C3=CC=CC(F)=C3)C1 CC(=O)N1CCC[C@@H1]1C(=O)N(C)C2CCN(C(=O)C[C@@H1]3SC(=N)NC3=O)CC2 COCC[C@H1](CNC(=O)C=1SC=NC=1C)NC(=O)C[C@H1]2OC(=O)C3=CC=CC=C32 CCC1=NOC(CCC(=O)N[C@H1]2CCC[C@@H1]2NC(=O)COC3CCOCC3)=N1 CSC1CN(C(=O)C2(CCNC(=O)CN(C)C(=O)C(C)C)CC2)C1 C[C@@H1]1CCC[C@@H1](C(=O)NCCCNC(=O)CC(C)(C)C(F)F)CC1 CCC1=NC(C(=O)N[C@@H1]2CC[C@H1]3C[C@H1]2CN3C(=O)C4CC(=O)NC(=O)C4)=N[NH1]1 CC(C)C[C@H1](C)CN=C(NCCC12CC3CC(CC(C3)C1)C2)N[C@@H1](C)[C@H1]4CCCO4 CC=1C=CSC=1CC(=O)NC[C@H1](C)N(C)C(=O)CN2CCC[C@H1]2C CCO[C@@H1](CN=C1N=C(CC2=CC=CC=C2)[NH1]S1)C3=CC=CC=C3 CC=1N=C(CC2CC2)OC=1C(=O)N3CCC[C@H1]3CN(C)C(=O)C[C@@H1]4C=CCCC4 CC=1OC=NC=1C(=O)N[C@]23CCCCC[C@@H1]2N(C(=O)C=4C=C(C(C)C)[NH1]N=4)CC3 C[C@@H1]1CCC=C1C(=O)N[C@]2(C(=O)NC3CCC=CCC3)C[C@H1]2C C[C@H1](NC(=O)C1(C2CCC2)CCC1)C3CCN(C(=O)COCP(C)(C)=O)CC3 CC[C@H1]1CCCC[C@@H1]1C(=O)N2CC3(CC(NC(=O)C=CC4=NC=C(C)[NH1]4)C3)C2 CCCC(=O)N1CCN(C2=CC=C([N+1](=O)[O-1])C=C2S(C)(=O)=O)CC1 CC1=C[NH1]N=C1C(=O)NCC[C@H1]2C[C@@H1](NC(=O)CN3C=C(C4CCC4)N=N3)C2 CC[C@@H1](C)C(=O)N1CCC[C@H1]1CNC(=O)C2=CC=C3N=CC(Br)=CC3=C2 CC[C@H1](C#N)C(=O)NC[C@@H1]1C[C@@H1](C)N(C(=O)[C@H1]2C[C@H1]3C=C[C@@H1]2CC3)C1 COC(=O)NCC(=O)N1C[C@@H1]2C[C@H1](C(=O)NCCN3CCOC3=O)[C@@H1](C2)C1 CC(=O)N1CCC[C@H1](CNC(=O)C2=CC(C(N)=O)=CS2)CC1 CCCOC1=CC=C(/C=C/C(=O)N[C@@H1](C)C2(CNC(=O)[C@@H1]3C=CCC3)CC2)C=C1 O=C(O)CC1=CC=C(CNC=2C=C(C(F)(F)F)SC=2Br)O1 O=C(NCCCCCCNC(=O)C1=CN=C2C=CC=NN12)C3=CN4C(=N3)SCC4 COC[C@]1(C)CCCN(C(=O)[C@@H1](C(C)C)[C@H1](C)NC(=O)/C=C/C(F)F)C1 C[C@@H1](NC(=O)C1=CN(C(F)F)C=N1)[C@@H1](CO)NC(=O)C2=CC=C(Cl)[NH1]2 CC1=CC=C2OC(C(=O)N3CC[C@H1](NC(=O)C4=CC(C)=C(C)[NH1]4)[C@@H1](O)C3)=CC2=N1 CCN1C=C([C@@H1](C)NC(=O)[C@]2(CC)CCN(C(=O)C3=CN=C(O)C=C3C)C2)C=N1 C[C@@H1](CC(F)F)C(=O)N1C[C@@H1]2C[C@H1](C1)CN(C(=O)CC3C(C)(C)C3(C)C)C2 O=C1CC[C@H1](CNC(=O)[C@@H1](F)C2=CC=C(C(F)(F)F)C=C2)CN1 CCC1=NC(C(=O)NC2C[C@H1](CNC(=O)C3=CSC=C3C(F)F)C[C@H1]2C)=C(N)S1 CC=C(F)C(=O)N1CC[C@H1](C)[C@H1](NC(=O)C2=CN=C(C=3C=CSC=3)S2)C1 CN(C)C1=NC=C(C(=O)NC[C@@H1](CC2=CC=CC=C2)N(C)C(=O)CC#N)O1 C#C[C@H1](CNC(=O)[C@H1](CC(C)(C)OC=O)N1CCC[C@@H1](O)[C@@H1]1C)CC(C)(C)C C#C[C@H1]1CC[C@H1](C(=O)NCC[C@@H1]2CCN(C(=O)CCN3CC[C@@H1](F)C3)C2)CC1 COC1=CC=C2C(=C1)C(C)(C)CN([C@H1](C(=O)NC(C)(C)C)C=3C=CSC=3Cl)C2 CC1=NON=C1CC(=O)N2CC3(CCC3)C[C@@H1]2C(=O)NC[C@H1](O)C(F)F C[C@H1](NC(=O)C(C)(C)C)[C@@H1](C)C(=O)N[C@@H1](CO)CC(F)(F)F CCCC1=CC=C(N2C=C(CCN(C)C(=O)CCC3=NC(C)=C(C)[NH1]3)N=N2)C=C1 CC1=CC=NC=C1CC(=O)N2C[C@H1](C(=O)NCCO[C@H1]3CC3(F)F)[C@@H1](C(C)C)C2 CN1C=C(C2CCN([C@H1](C(=O)NCCCF)[C@@H1]3CC34CCC4)CC2)C=N1 CC(C)(C)ONC(=O)CCCC(=O)NC[C@@H1]1CN(C(=O)C(N)=O)[C@@H1]2C[C@@H1]12 C=C(Cl)CCC(=O)N1CCOC[C@](F)(CNC(=O)[C@H1]2CCCC[C@@H1]2O)C1 CC=1N=NSC=1C(=O)NC[C@H1](C)CNC(=O)C2=CC=C3C(=C2)CCCS3 CCCC(C)(C)C(=O)NC[C@@H1]1C[C@H1](C)N(C(=O)[C@H1]2CCSC3=CC=CC=C32)C1 COC[C@@H1](CC(=O)N(C)CC(C)(CO)CO)NC(=O)CCCCCC(C)C O=C(N[C@@]12CC[C@@H1](C1)N(C(=O)C3=CN=C4N=CN=C(O)C4=C3)C2)C5=CC=NC=C5 CCC1=NC=CC=C1C(=O)N[C@@]23CCC[C@H1]2N(C(=O)CCCCSC)CCC3 CN1C=NN=C1CCCC(=O)N[C@@H1]2CCN(C(=O)CN3C=C(C#N)C=N3)C24CC4 CN1C=NC=C1C2=CN([C@@H1]3CON(C(=O)C4=CC=C(CN5CCCC5)O4)C3)N=N2 C[C@@H1]1C[C@H1](C(=O)NCCC2CN(C(=O)[C@@H1](O)C3=CC=C(F)C(F)=C3)C2)CCN1C C=C[C@@H1]1C[C@H1]1C(=O)N2CCN(C3CCC(NC(=O)CCCN(C)C)CC3)CC2 C=C=C[C@@H1](C)C(=O)N(C)C[C@@H1](C)NC(=O)CC1=CC=CN=C1O N=C1C=CC2=CC(C(=O)NC/C=C/CNC(=O)CN3N=NC(=O)[NH1]3)=CC=C2[NH1]1 C=CC[C@@]1(NC(=O)C=CC2=CN=CS2)CCCN(C(=O)C3C[C@@H1]4CC[C@H1](C3)S4)C1 CCC=1C=C(C(=O)N[C@H1]2CCOC[C@H1]2NC(=O)C3=CC=C(O)C(Cl)=N3)SC=1C CC1=CSC=2C=C(C(=O)N3C[C@@H1]4CCCN(C(=O)C5=CN=N[NH1]5)[C@@H1]4CC3)[NH1]C1=2 CCOC=CC(=O)N[C@H1]1C[C@@H1](CNC(=O)C2=CC=C(CC(N)=O)C=C2)C13CCC3 CN1N=CN=C1CCCNC(=O)[C@H1](F)CC(C)(C)NC(=O)[C@@H1](O)CC(F)(F)F CC1=CC=C(CC(=O)N2CC[C@@]2(C)CC(=O)NC[C@H1]3CCN(C)C3)O1 O=C(C[C@@H1]1CC1(Cl)Cl)N2CCCC3(CCN(C(=O)C4=CC=C(O)C=N4)CC3)C2 CC1=CC=CC=C1[C@@H1](C(=O)NC[C@@H1](NC(=O)CC=2C=CSN=2)C(C)C)N(C)C CO[C@@H1]1C[C@@H1](CNC(=O)C(C)(C)C(N)=O)N(C(=O)CC2=CC=C(Cl)C=N2)C1 CC(C)[C@H1](C)NC(=O)CC[C@H1]1CCN(C(=O)C(C)(C)[C@H1]2CCOC2)C1 CC=CC[C@@H1](CO)NC(=O)N[C@H1]1CCOC(C)(C)OC1 C=C[C@@H1](C)CCNC(=O)C1=CON=C1CNC(=O)[C@@H1](C)CSC CCC1=CC=C(CNC(=O)C(=O)N[C@@H1]2CCC3=NC=CC=C3C2)C(C)=C1 CCOC1=CC(C2=CN=CC(C(=O)NC3=CC=C([N+1](=O)[O-1])C(Br)=C3)=N2)=CN=C1F CCC(=O)N1CC[C@H1](NC(=O)[C@](C)(C2CC2)N(C)C(=O)C34CC(F)(C3)C4)C1 CC1=NN(C)C(C(=O)N[C@@H1]2CC[C@H1](C)N(C(=O)CCCC3=CC=CC=N3)C2)=C1Cl CC1=CC(CCC(=O)NC2CCC3(CC2)C[C@H1]3NC(=O)C4=CC(Cl)=CC=N4)=N[NH1]1 CCN1CC[C@H1](N(CC)C(=O)[C@H1]2C[C@H1](C)N2C(=O)CN3CCOCC3)C1 CC(C)COCC(=O)N[C@@H1]1COC[C@@H1]1NC(=O)C=2N=C3N=CC=CN3N=2 CCCC(C)(C)CC(=O)NC[C@@H1]1C[C@H1]1NC(=O)C2=CC(OC)=CN=C2F CC1=NN(C)C=C1COC(=O)[C@@H1]2CC(=O)N(C(=O)C=3C=CC=C4N=C(N)SC4=3)C2 CC(C)CC[C@@H1](NCC1=NN=CS12)CC2 C=C[C@H1](COC)NC(=O)[C@H1]1CCN(C(=O)CC2(O)CCCCC2)C(C)(C)C1 C[C@@H1](C(=O)N[C@@H1]1CC[C@H1](NC(=O)CN2CCOCC2)C1)N3C=C(Br)C=N3 CCO[C@H1](C)C(=O)N1CCN2CCOC[C@]2(CNC(=O)CC=3C=N[NH1]C=3)C1 O=C(C[C@H1](NC(=O)C[C@H1]1CSCCO1)C(F)F)NC2(CO)CC(O)C2 COC(=O)NCCC(=O)NC[C@H1]1CC[C@H1](NC(=O)C(C)(C)F)CC1 O=C1CC[C@H1](C(=O)N[C@H1](CNC(=O)C2=NC=NC(O)=C2Cl)C3CCCCC3)O1 O=C(NC[C@@]1(O)CCCN(C(=O)C2=CNC3=NCCC3=C2)CC1)[C@H1](O)C(F)(F)F CC1=CN=CC(C)=C1C(=O)N2CCC3(CC2)C[C@@H1]3C(=O)N[C@H1]4CCCC(F)(F)C4 CC(C)N1C=CC(C(=O)N2CCCC[C@H1]2CC(=O)N3C[C@H1](O)C[C@@H1](O)C3)=N1 CN(CCCNC(=O)C1C2CC3CC(C2)CC1C3)C(=O)C4(S(C)(=O)=O)CC4 C=1C=2[NH1]C(Cl)=NC(=N[C@H1]3CC34CC(NC(=O)C5=CC=NN5C)C4)C=2C=1C#N CC1(C)OCC[C@H1]1C(=O)N[C@H1]2C3C[C@H1]4[C@@H1](C3)C24C(=O)N5CC(C(N)=O)C5 O=C(N[C@H1]1C=CCN(C(=O)[C@@H1]2C[C@H1]2C3=CC=C(F)C(F)=C3)C1)C4=CCCC4 CN(CCOCCNC(=O)C1CC(=O)CC(=O)C1)C(=O)[C@H1]2CCCC=3N=N[NH1]C=32 CO[C@@H1](C(=O)N[C@H1](CO)CNC(=O)CN1SC(=O)C2=CC=CC=C21)C3CC3 C[C@@H1]1C[C@H1](CC(=O)N[C@](C)(CO)C(F)F)CN1C(=O)CCC2(C)CC2 C[C@H1](C(=O)C1=CC=CC(F)=C1)N(C)[C@@H1]2CCN(C(=O)CC3=CC=C(Cl)C(F)=C3)C2 CCC[C@H1](NC(=O)C[C@H1]1C=C[C@@H1](NC(=O)CN(C)C(=O)COC)C1)C(=O)N(C)C O=C(C1CCCC1)N2CC[C@]3(CCCN3C(=O)C4=CC=C(CCF)C=C4)C2 COC1=C[NH1]N=C1C(=O)NC[C@@H1](C)N(C)C(=O)[C@H1](C)SC2=CC=C(F)C=C2 CC[C@@]1(NC(=O)C=2SC=CC=2SC(F)F)CCCN(C(=O)CN3N=NN=C3C)C1 COC[C@](C)(OC)C(=O)NC[C@H1](O)CC(=O)N(C)CC1CN(C)C1 O=C(CN1C=CC(C2CC2)=N1)NCC3=CCN(C(=O)C4=CC(Cl)=NO4)CC3 CNC(=O)CCCCC(=O)NC[C@@H1]1C=CCN1C(=O)[C@@H1]2CCC3=NC=NC=C3C2 CC1=NSC=C1CC(=O)NC[C@@H1](CC(C)C)NC(=O)[C@@H1]2CCCN2CC(C)C O=C(CC1CCC1)NC[C@H1](O)CC(=O)N[C@H1]2CCC3=CC=CC=C32 CCC1=NSC=C1NC(=O)[C@@H1]2CC[C@H1](C3CC3)N2C(=O)CCC4=CSC=N4 C[C@H1]1CC[C@@H1](C(=O)NCC2(CO)CCN(C(=O)CCC3=CC=CS3)CC2)S1 CN(CCN(C)C(=O)[C@H1]1C[C@H1]2[C@@H1](C1)C2(C)C)C(=O)CCCNC(=O)C3=CC=CS3 CC1=CC(Cl)=C(C(=O)NC[C@@]2(CO)CCN(C(=O)[C@H1](C)SC(C)C)C2)C=C1F CO[C@@H1]1C[C@@H1](CNC(=O)C2=NN=C(O)N=C2O)N(C(=O)CN3C=CN=N3)C1 CC1=C(F)C=CC=C1C2(C(=O)NC[C@@H1](NC(=O)[C@@H1]3C[C@H1]3F)C4CCC4)CC2 C=CC1(NC(=O)C2=CC=C3N=NN(CC4=CC=CO4)C3=C2)CON=C5C1=NOCC5 CCC=1SC=CC=1C(=O)N[C@@H1]2C[C@@H1]3C[C@H1]2N(C(=O)[C@H1]4C[C@@H1](N(C)C)C4)C3 N#CCC(=O)NC1=NC=C(C2=CC=CC(N3C=CC=N3)=C2)S1 CCC1=NSC(N2[C@H1]3CC[C@H1]2[C@H1](CNC(=O)C4=CN=CC5=C(O)N=CC=C45)C3)=N1 C[C@H1]1OCC[C@@H1]1CC(=O)N2CC3(CN(C(=O)C4=CC=CC(C5=CC=CO5)=C4)C3)C2 CCS(=O)(=O)C1=CC=C(C(=O)N2CCC[C@H1](C3=CN(CCO)N=N3)C2)C=C1 CC1=CN=C(CCNC(=O)NCCN2CCSCC2)N=C1C CCCC[C@H1](CC(=O)N[C@H1]1CCS(=O)(=O)C1)NC(=O)C2=CC=C(CO)O2 CCN1C=CC(C(=O)N2C[C@@H1](C)[C@H1](CNC(=O)C[C@@H1]3CC4(CCC4)CO3)C2)=C1C CC1=NC=C(C)C(=NC[C@@]2(O)CCCN(C(=O)CC3C[C@H1]4C[C@@H1]4C3)C2)[NH1]1 O=C([C@H1]1COC2=CC(F)=CC=C2C1)N3CC[C@H1](C4=CN(CCCCCCO)N=N4)C3 O=C(N[C@@H1]1CN(C(=O)C2=N[NH1]C3=C2CCSC3)[C@@H1]4C[C@@H1]14)C=5N=COC=5C6CC6 O=C(C=CNC1=CSCC1)N2CC[C@H1](OCC3=CC=CC=N3)C2 C#CCNC(=O)CC(=O)N[C@H1]1CCC[C@H1](NC(=O)[C@@H1]2C[C@H1]3CC(=O)[C@H1]2O3)C1 CON=CC(=O)NCC1(NC(=O)CCSC2=CC=C(C#N)C=C2)CC1 C[C@H1](C(=O)N[C@@H1]1CC[C@H1](CNC(=O)[C@H1]2CNC(=O)CC23CCC3)C1)S(C)(=O)=O C=C[C@H1](CC)C(=O)N[C@@H1](CN=[N+1]=[N-1])C(=O)N1CCC2(CC(OC)C2)C1 C#CC#CC(C)(C)NC(=O)[C@H1](C(C)C)[C@H1](C)NC(=O)C1=CSC(CO)=N1 CC=1C=NSC=1C(=O)N[C@H1]2CN(C(=O)CCCN=[N+1]=[N-1])C[C@@H1]2C3CC3 CC(=O)C1=CC=NC=C1NC(=O)[C@@H1]2C[C@H1](F)CN2C(=O)C3=CC(Cl)=C(Cl)S3 CO[C@@H1](C(=O)N1C[C@H1]2CC[C@@H1]1[C@@H1]2NC(=O)C3=CC=NC=4C=CSC3=4)C(C)(C)C CCCC[C@H1](CC)CC(=O)N1CC[C@@H1](NC(=O)C2=C[NH1]N=C2[N+1](=O)[O-1])[C@H1](CO)C1 C[C@@H1](O)[C@H1]1CCCN1C(=O)[C@H1](CNC(=O)C=2C=CN(C)N=2)N(C)C O=C(NCC1(CNC(=O)C2(F)[C@H1]3CCCC[C@@H1]32)CC1)[C@H1]4CC=CCO4 COC(=O)NCCCC(=O)N1CCCN(C(=O)[C@H1]2CCS(=O)(=O)N2)[C@H1](C)C1 C=CCC1(NC(=O)[C@H1]2C(Cl)(Cl)C23CC3)CCN(C(=O)[C@@]4(O)CC4(C)C)CC1 COCCO[C@@H1]1CCCN(C(=NCC2CCC2)NCC3=CC=C(C)C=N3)C1 C[C@H1]1C[C@@H1]1C2=CC=C(C(=O)NCC34CC(NC(=O)CN5C=NN=N5)(C3)C4)O2 CN(C)C1(CC(=O)N2C[C@@H1]3C[C@H1](NC(=O)C4(C5=NC=CO5)CC4)[C@H1]2C3)COC1 C[C@@H1](CO)C(=O)N1C[C@H1]2CC[C@H1]1CN2C(=O)C3=CC=CC=C3C4=CC=CC=C4 CC(C)N1CCO[C@@H1](C(=O)N2CCN(C(=O)CNC(=O)C3=CN=CC=N3)CC2)C1 C=CC1(CC(=O)NC2CCC(C)(OC)CC2)CN(C(=O)C(CC)(CC)CO)C1 C[C@H1]1[C@@H1](NC(=O)C(C)(C)F)CCN1C(=O)[C@@H1](NS(=O)(=O)C2CC2)C(C)(C)C CCNC(=O)C(=O)N[C@H1]1C[C@@H1](CNC(=O)[C@H1](F)CC2=CC=CC=C2)C1 CC1(C)C[C@H1]1CCC(=O)NC[C@H1]2CC[C@H1]2NC(=O)CC[C@@H1]3NC(=O)NC3=O CC[C@@H1](OC1=CC=CC=C1F)C(=O)N2C[C@H1](NC(=O)C3=CC=C(C)[NH1]3)CC2(C)C CC1=CC(C(=O)N2CC(CNC(=O)[C@@H1]3CCS[C@H1](C)C3)C2)=C4N=C(C)N(C)C4=N1 C=CCCCCCCC(=O)N1C[C@H1]2[C@H1](CNC(=O)C3=CCCOC3)[C@H1]2C1 CC[C@H1](CC(=O)N[C@@](C)(CSC)C(=O)NC[C@@H1]1[C@H1](CO)C1(F)F)C(C)C COC1=NC=C(Cl)C=C1C(=O)NCCCNC(=O)C=2C=CN3C=2CS(=O)(=O)CC3 CC1=CC=CC=2C=C(C(=O)NCCOC3=C[NH1]C4=NC=CC4=C3)[NH1]C1=2 CN(CCCCNC(=O)[C@H1](O)CF)C(=O)C[C@H1]1OCCC2=CC=CC=C21 O=C1C[C@@H1]([C@H1]2CCCN2C(=O)NC3=CC=C(OC(F)F)C(Cl)=C3)CN1 COC(=O)C12CC(NC(=O)COC3=CC(OC(F)(F)F)=CC=C3Br)(CO1)C2 CC1=CSC(CN(C)C(=O)[C@@H1]2CCN(C(=O)C=3N=NN(C)C=3C)[C@@H1](C)C2)=C1 C[C@H1](NS(=O)(=O)C1(F)CCC(C)(C)CC1)C2=CC3=CN=CC=C3O2 CC(=O)C1=CC=C(C(=O)N2C[C@H1]3C[C@@]3(NC(=O)[C@@H1]4CCC5(CCC5)OC4)C2)C=C1 C[C@H1]1C[C@H1](CNC(=O)C2=CN(C)N=C2C3=CC=CO3)CN1C(=O)C4=CN=C(O)O4 CN1N=C(C(=O)N[C@@H1]2C[C@@H1](NC(=O)CC3=CC=CC(O)=C3F)C24CCC4)C=C1F O=C(CC1=COC2=CC(F)=CC=C12)N[C@H1]3CCN(C(=O)C=4C=CSC=4)C3 COC1=CC(NC(=O)C2CN(C(=O)C3=CN=NN3C)C2)=CC(Br)=C1Cl CCN(C(=O)C=1C=NN2C=C[NH1]C(=O)C=12)C3CCN(C(=O)CSCC(C)=O)CC3 C=C(C)CCONC(=O)[C@@H1]1[C@H1]2C[C@H1](O)[C@H1](C2)N1C(=O)C3=CC=CC(OC)=C3 CCN(CCNC(=O)CCCC(C)=O)C(=O)[C@@]12CSC[C@H1]1C2 COC1=CC(C(=O)N[C@H1]2CCCC3=C(F)C=CC=C32)=CC(OC)=N1 CO[C@H1](C)[C@@H1](C(=O)NC1C2CC(NC(=O)CN3CCOCC3)(CC1)CC2)N(C)C C[C@@H1]1C[C@H1](NC(=O)C2=CC=CN3C(O)=NN=C23)CN(C(=O)COCCN(C)C)C1 CC(C)[C@H1](O)[C@H1](C)C(=O)NC(CO)(CO)CN(C)C(=O)C1=CC(O)=CC=C1F CC1=CC(C(=O)N[C@@H1](C)C[C@@H1](C)NC(=O)OC(C)(C)C)=CC=C1F COC1(CCNC(=O)C2=CC(C)=NO2)CN(C(=O)CC(F)(F)F)C1 CC1=CC=C(C)C(C(=O)N(C)C[C@@H1](C)CNC(=O)CC2=CC(F)=CC=C2C)=N1 CC(=CC(=O)NCC[C@H1](C)N(C)C(=O)C1=C(C)OCCS1)C(C)C C[C@H1](CC(=O)NC[C@@H1]1C[C@]2(CCN(C(=O)[C@H1]3COC(=O)C3)C2)CO1)CC(F)(F)F C=CC[C@@]1(NC(=O)[C@H1](C)N2C=C(C)C=N2)CCN(C(=O)C(C)=C3CC3)C1 CCCC(C)(C)C(=O)N1CC2(CC(C(=O)NC3=C([N+1](=O)[O-1])C=CC(Cl)=C3C)C2)C1 C=C[C@@](C)(CC)C(=O)N1CCC(CCOC)(NC(=O)CCCN(C)C(C)=O)CC1 C[C@@H1](C(=O)N[C@@H1](CC=1C=N[NH1]C=1)C(=O)N2CCC(C)(C)CC2)N3C=CC=N3 COC(=O)C1=CC=C(C(=O)N2CCO[C@@H1](CN(C)C(=O)C=3C=NN(C)C=3C)C2)O1 CC=1C=C(CCC(=O)NC[C@]2(C)CCC[C@H1]2NC(=O)C3=CC(O)=CC(F)=C3)ON=1 CC[C@@H1]1CC[C@H1](NC(=O)C2=CC=3[NH1]C=CC=3C=C2C4=CN=CC=C4C)C1 CN(C)C(=O)CC(=O)N[C@H1]1C2C[C@H1]3[C@@H1](C2)C13C(=O)NCCC4=C[NH1]N=C4O C=C[C@H1](C)CC(=O)N1C[C@@H1](F)C[C@H1]1CN(C)C(=O)[C@H1](C)[C@H1](O)C(C)C COC1=CC=CC(C(=O)N2CC[C@@H1](NC(=O)CCC3=CC=CC=C3Cl)C2(C)C)=N1 CC=CC(=O)N[C@@H1]1CCC[C@H1]2CN(C(=O)C=3N=C(O)SC=3C)C[C@@H1]21 COC(=O)[C@H1]1CCN(C(=O)[C@H1]2C[C@H1](F)CN(C(=O)C=3C=C(Cl)N(C)N=3)C2)C1 C#CCN(CC=C)C(=O)[C@H1](CCOCCO)NC(=O)[C@H1](O)CSC CCOC(=O)C1=CC(S(=O)(=O)NC2=NC([C@@H1](C)CC3CCC3)=CS2)=CC=C1F C=C1C[C@H1]1C(=O)N[C@H1](C)C(=O)NCCCOC CC1=C(Br)C=CC(F)=C1CNC(=O)N[C@H1]2C[C@@H1](N(C)C)C23CCC3 CCC(C)=C(C)C(=O)NCC(=O)N[C@@H1](CC)C(=O)N(C)C CCC[C@H1](CNC(=O)C1(CC)CCOCC1)C(=O)N(C)C2CCOCC2 CC(C)[C@H1](C)C(=O)NC[C@@H1]1CC(C)(C)CN1C(=O)C[C@@H1](C)C2=CC=NC=C2 CCN(CC)CCC(=O)N1CCN(C(=O)C[C@H1](NC(C)=O)C(N)=O)[C@@H1]2COC[C@@H1]21 CC[C@@H1](CC(=O)N(C)[C@@H1](CC(C)C)C(=O)NCC1CC(F)C1)C(F)F CCOC(=O)[C@H1](CC)C(=O)NCCC(=O)N[C@@H1](CO)CCC(C)C C=CC1(CC(=O)N2CCN(C(=O)C3=CC=C(CC)C(F)=C3)[C@@H1](C(C)C)C2)CC1 CC[C@@H1](O)C(=O)N(C)[C@@H1](C)CCNC(=O)C1=CC=CC([N+1](=O)[O-1])=C1C COC=1C=C(C=CC(=O)N2CC[C@H1](NC(=O)CCCC#N)[C@@H1](CO)CC2)SN=1 COC(=O)C[C@@H1](C)NC(=O)C[C@@H1](NC(=O)[C@@H1](C)N=[N+1]=[N-1])C1CC1 CCN(C(=O)CCNC(=O)CO)[C@H1]1CCN(C(=O)C2=CC=NC(CN(C)C)=C2)C1 C[C@H1]1OCC[C@H1]1C(=O)N[C@H1]2C[C@@H1](NC(=O)C3=CN=CC=C3C(C)(C)C)C2 CCN(C(=O)C1=CN=C(OC)C(Cl)=C1)[C@H1]2CCN(C(=O)CN3CCC[C@@H1]3C)C2 CCN1N=CN=C1[C@@H1](C)NC(=O)[C@H1](NC(=O)C2=CC(Cl)=CS2)C3(O)CCCCC3 C[C@H1](NC(=O)C[C@H1]1[C@@H1]2CN(C(=O)C3=CCCCC3)C[C@H1]12)[C@H1](C)N4C=CC=N4 CC(C)CC/C=C/C(=O)NC(C)(C)CCN(C)C(=O)C=1C=C(O)N(C)N=1 COCCC(C)(C)C(=O)N[C@H1](C(=O)NCC[C@H1]1COCCO1)C(C)C C[C@@H1](OC1=CC=CN=C1)C(=O)NCC(C)(C)CNC(=O)C[C@@H1](CN(C)C)C(F)F COC[C@@H1](NCC1=C[NH1]N=C1C2=CC=CC=C2C)C3=CC=C(F)C=C3 CNS(=O)(=O)CC(=O)NC1([C@@H1]2CCCN2C(=O)C=CCOC)CC1 CN(O)C(=O)CNC(=O)[C@H1]1CC(C)(C)CN1C(=O)[C@H1]2C=CCC2 CCOC1(CNC(=O)CNC(N)=O)CN(C(=O)C=CC2=COC=N2)C1 C=CCCC(=O)NCCN(C)C(=O)C=CC1=CC=C(OC)C=N1 CCCSCC(=O)N[C@@H1]1CCCC[C@H1]1NC(=O)[C@H1](C2=CN=CN2C)N(C)C C[C@@H1](NC(=O)NC[C@@H1]1CNC(C)(C)C1)C2CC2 CCN(CC(F)(F)F)C(=O)[C@@H1]1C[C@@H1](O)CN1S(=O)(=O)C2=CC=CC=C2Cl CC(=O)CCCCC(=O)N1CCC([C@H1](C)C(=O)NC2=CC=C(C(C)C)C=C2)CC1 C#CCN(C)C(=O)[C@@H1]1CCCCN1C(=O)C2CCC(C#N)CC2 O=C(CC1CC1)N[C@@H1]2CCCC[C@]23CCN(C(=O)[C@@H1]4[C@H1]5[C@H1]6C[C@H1]4C(=O)[C@@H1]56)C3 O=C(C1=CC=CC(CCO)=C1)N2CCC[C@@H1](CO)[C@@H1]2CO CN1C=NC=C1[C@H1](O)C(=O)N2CCC[C@]3(CCCN3C(=O)C4=CC(C#N)=C[NH1]4)C2 CC1=NC=C([N+1](=O)[O-1])C=C1C(=O)N(C)C[C@H1](C)NC(=O)CCC=2C=C[NH1]N=2 CC[C@@H1](O)C(C)(C)C(=O)NC[C@H1]1[C@@H1]2CN(C(=O)C3CCSCC3)C[C@H1]12 C#CCOCCC(=O)N[C@@H1](C1=CC=CC=C1)[C@@H1](NC(=O)/C(C)=C/CO)C(C)C CCN1N=C(C(=O)N2CC[C@H1](CNC(=O)CCC3CC(OC)C3)C2)C=C1C4CC4 CNC(=O)C1(C(=O)N2[C@H1]3CC[C@@H1]2C[C@H1]3CNC(=O)C4=C(F)C=C(F)C(O)=C4)CC1 CC[C@@H1](C(=O)NC1(C)CC2(CCC2)C1)N(C)C(=O)[C@@H1]3COC(=O)N3 C[C@H1]1[C@@H1](C)[C@@H1]1C(=O)N(C)C[C@@H1](C)NC(=O)C2=CC(Cl)=CC([N+1](=O)[O-1])=C2 CC(C)C1=CC=C(C(=O)CNCCCC2=CC=C(I)C=C2)C(O)=N1 C[C@@H1]1C[C@H1](NC(=O)C(C)(C)F)CN1C(=O)[C@@H1]2CCCO2 CN1C=NN=C1CC2=CC=CC(NC(=O)NCCOC3CCCCCC3)=C2 CC(C)=CCCC(=O)N1CCN2N=CC(CN(C)C(=O)[C@H1]3CCCC[C@@H1]3O)=C2C1 CC1=CC(C(=O)N[C@H1]2COCCN(C(=O)C3CC=CC3)C2)=CC=C1Br O=C(N1CC=CCC2(CCCC2)C1)[C@@]3(F)CCN(CC4=CC(F)=C(F)C(F)=C4)C3 C[C@]1(CNC(=O)C2=CC=C(O)C3=NC=CC=C23)CCN(C(=O)C4=CN=CO4)C1 CC(C)(C)C1=NC=C(C(=O)N2CC(C3(NC(=O)[C@@H1]4[C@H1]5CCC(=O)[C@H1]54)CC3)C2)O1 CC1=CC=C(CC(=O)N[C@H1]2[C@@H1]3C[C@H1]2N(C(=O)C4CCN(CC(F)(F)F)CC4)C3)S1 CO[C@H1]1CCC[C@@H1]1C(=O)NCCCNC(=O)C2=CN=CC(Br)=C2Cl CO[C@@]1(CNC(=O)[C@H1](CC(C)C)N(C)C)CCN(C(=O)C2(SC)CC2)C1 CN(CCCNC(=O)[C@H1]1CCO1)C(=O)C2=CN(C)N=C2C3=CC=NN3C CSCC(=O)N1[C@H1]2CC[C@H1]1[C@@H1](C)[C@H1](NC(=O)C3=COC4=C3C(=O)NCCC4)C2 C[C@H1]1CN(C(=O)[C@H1](C)[C@@H1]2CCN(C(=O)[C@H1]3CC34CCCCC4)C2)[C@@H1](C)CO1 COC=1C=C(C(=O)NC2C[C@H1]3CN(C(=O)/C=C/C(C)C)C[C@@H1]3C2)[NH1]N=1 C[C@@H1](CN(C)C(=O)CCOCC1=CC=CC=C1)NC(=O)C23CCN(CC2)C3 CC[C@H1](C(=O)NC[C@@]1(C)CCN(C(=O)[C@H1](CC)N(C)C)C1)C2=CC=CC=C2 CCCC[C@H1](CNC(=O)C(C)(C)C(F)F)NC(=O)C1CC(CN(C)C)C1 COC1C[C@H1]CN(C2=NC(=N)[NH1]C(=NCC=3C=C(C(C)C)ON=3)[NH1]2)CCO1 CCCCN(CCCC)C(=O)[C@H1]1CN(C(=O)C=2N=COC=2C(C)C)CCO1 CCC(=O)N[C@H1]1CC[C@H1]1CNC(=O)CN(C)C2=NC=NC=3SC=CC2=3 CC1=CC=C([C@H1](C(=O)NCC(F)F)N2CCC2(C)C)C=C1[N+1](=O)[O-1] O=C(CC1=CC=C(F)C=C1Cl)OC[C@@H1]2CC[C@@H1]3COCC[C@@H1]3O2 CC(=O)[C@@H1](C)C[C@H1](C)C(=O)N1[C@@H1]2CC[C@@H1](C2)[C@H1]1CC(=O)NC3(CF)CCCC3 O=C(NCC12CC(CN1C(=O)CC3=CC(F)=CC=C3O)C2)C4CC(Cl)(Cl)C4 CC1=CC=C(Cl)C=C1C(=O)N2CC=C[C@H1](NC(=O)CC3=CC=C4C(=C3)CCC4)C2 CC1=CC=CC2=C1O[C@H1](C(=O)N3C[C@H1]4CN(C(=O)C5(C)CC(C#N)C5)C[C@H1]4C3)C2 C[C@@H1]1C[C@@H1](C(=O)NC[C@@H1]2CCC3(CO2)CC(NC(=O)C=CBr)C3)CCS1 COCCCCC(=O)N[C@H1]1CCCCC12CCN(C(=O)[C@@H1](CC3CC3)OC)CC2 CC(C)=C(F)C(=O)NC[C@@]12CN(C(=O)C3CN(C(N)=O)C3)C[C@@H1]1CCO2 CC(C)[C@H1](O)C(=O)N1CCN(C(=O)C2=CC=C(CN3C=C(Cl)C=N3)O2)[C@@H1](CO)C1 CCC[C@]1(C)CCCN(C(=O)C[C@H1](C)CNC(=O)C2C[C@H1]3COC[C@@H1]3C2)C1 C#CC[C@@H1](O)C(=O)N1CCC(O)(CNC(=O)C2=CC=CN=N2)CC1 C[C@@H1]1CC[C@@H1](CCC(=O)NC[C@H1]2C[C@H1](NC(=O)C3(C#N)CCCC3)C2)O1 CC[C@@H1](CCC(=O)N1CCC(C(N)=O)CC1)NC(=O)C2(C=3C=C[NH1]N=3)CC2 CN(CCOC1CN(C(=O)[C@@H1](F)C(F)(F)F)C1)C(=O)COCC2CCCC2 CO[C@H1]1CN(C(=O)[C@@H1](C)C2=CC=CS2)CC[C@H1]1NC(=O)C3=CSC(C)=N3 CCCCCCOCC(=O)NC[C@@H1]1[C@@H1](C)CCN1C(=O)C2CC(C(C)C)C2 CC=C(C)C(=O)N[C@@H1](C)CN(CC)C(=O)[C@H1](O)C1CCOCC1 CC=1C=CSC=1C(=O)N2CC3(CC(NC(=O)C4=NC=NC(O)=C4Br)C3)C2 CC(C)(C)OC(=O)N1CCC(C[C@@H1](O)C(=O)N2CCC(C)(CO)CC2)CC1 COC(=O)[C@@H1]1CC[C@H1](C(=O)NC[C@@H1](CO)NC(=O)C=2C=NSC=2)O1 CCOC(=O)CC(=O)N[C@H1]1COCCN(CC2=CC=C3C=C(F)C=CC3=N2)C1 C/C=C/C[C@@H1](CC)C(=O)N[C@@H1]1CN(C(=O)C(C)(C)C=2C=C[NH1]N=2)CC[C@H1]1CO C[C@@H1]1[C@@H1](C(=O)N2CC[C@H1](NC(=O)CC3=CN=CC=N3)C4(CCC4)C2)C1(F)F C[C@H1]1CCN(C(=O)[C@@]23CCN(C(=O)CC=4C=CN(C)C=4)C[C@@H1]2C3)C1 CC(=O)N[C@H1](C(=O)NC[C@@H1](C)N(C)C(=O)CC[C@H1](C)C#N)C(C)C CC1=CN=C(NCC[C@H1]2CCCN(C(=O)C=CC3=CC(C)=CC(C)=C3)C2)N=C1O CCN1C[C@@H1](C(=O)N[C@H1]2CC[C@H1](NC(=O)[C@H1](F)OC(F)(F)F)CC2)NC1=O CCN(CCNC(=O)[C@H1](CCO)N(C)C)C(=O)C1=CC(C2CCC2)=NO1 CCC[C@]1(NC(=O)/C=C/CN(C)C)CCCN(C(=O)[C@H1]2C[C@@H1]2C(C)(C)C)C1 CCN1C=CC(CC(=O)N2CC[C@H1](C(=O)N[C@H1]3CCN4CC[C@H1]3C4)C2)=N1 COC(=O)N1CCC[C@@H1](C(=O)NC[C@H1](CO)NC(=O)C2C(C)(C)C2(C)C)C1 CC(C)O[C@H1]C[C@H1]CNC(=O)C1=CC=C2OC(=N)[NH1]C2=C1 O=C([C@H1]1CCC(F)(F)C1)N2C[C@@]3(C(=O)NC[C@@]45CC=C[C@@H1](C4)OC5)C[C@H1]2CCO3 CC[C@](C)(F)C(=O)NC[C@](C)(CO)NC(=O)C1=NC=CC2=CC=CC=C12 CN1N=CC=C1CCC(=O)N[C@@H1]2CCC[C@@H1]2NC(=O)COC3=CC=C(F)C(Cl)=C3 CC(C)C[C@H1](C(=O)N[C@@H1](C)C1=CN(C2=C(F)C=CC=C2Cl)N=N1)N(C)C CC[C@@H1]1CC[C@H1](C(=O)NC[C@@H1](C)N(C)C(=O)C2=CC=C([N+1](=O)[O-1])C(Cl)=C2)O1 COC1=CC=C(C2=CN(C3CN(C(=O)C45CCN(CC4)C5)C3)N=N2)C=C1Cl C[C@@]1(C(=O)N2CCN(C(=O)C=3C=CC(=O)N(C4CC4)C=3)[C@@H1](C5CC5)C2)C=CCC1 CC(C)(CF)C(=O)NC[C@@H1]1C[C@@H1]1CNC(=O)CC2=CC=C(OC(F)F)C=C2 CN1CCC[C@@H1]1C(=O)N2CC([C@H1]3CCCN(C(=O)CC4=CCOCC4)C3)C2 O=C(N=C1C=C[NH1]C=C1Cl)[C@H1]2C[C@H1](F)CN(C(=O)C3=CN=C4C=CC(Cl)=CN34)C2 COC(=O)[C@H1](F)CC1=CC=C(N[C@@H1](C=2C=CN(C)N=2)C3=NN=NN3C4(C)CC4)C=N1 C=C[C@@H1](C1CC1)N(C)C(=O)CC[C@H1](CC)NC(=O)[C@@H1]2[C@H1]3CCC[C@H1]32 CCC(=O)NCC(=O)N(C)C[C@H1]1CCCN(C(=O)C2=CC=C3[NH1]C(=N)OC3=C2)C1 CC=1C=C(C(=O)N2CC=C[C@@H1]2CNC(=O)[C@H1]3C[C@@H1]4CC[C@@H1]4C3)N5N=CN=C5N=1 CC(=O)N[C@H1](C(=O)NCCCCC(=O)N1CC[C@H1]1C2CCOCC2)C(C)C C#C[C@@]1(C(=O)N[C@H1]2C[C@@H1]2C=3C=CSC=3)CCN(C(=O)[C@H1]4C[C@H1](SC)C4)C1 CC=1C=C(C)N([C@@H1](C)C(=O)NCCCOCC(C)(C)NC(=O)C[C@@H1]2CCSC2)N=1 CCOCCCC(=O)N[C@@H1](COC)CC(=O)NCCSCCCO CCC1(CNC2=CC(S(=O)(=O)N[C@H1]3CC=CCC3)=CC=C2Br)CCCC1 COCCCOCCC(=O)N1C[C@@H1]2COCC[C@]2(NC(=O)CC=3C=NSC=3)C1 C[C@@H1]1C[C@H1](NC(=O)C2=C[C@H1]3CC[C@@H1](C2)C3)CN1C4=NN=C(C(C)(C)C)S4 CC1=CC=C(C(=O)NC[C@H1]2CC3(CO2)CN(C(=O)[C@H1]4C[C@H1]5C=C[C@@H1]4CCC5)C3)[NH1]1 COCCC[C@H1](NC(=O)C1=CC=C(C)N=N1)C(=O)N(C)CC2CC(F)(F)C2 O=C(NC1=CC(Cl)=CC(Cl)=C1O)C=2SC=CC=2NCC3=CC=CC=4N=CSC3=4 O=C(N[C@H1]1C[C@@H1](NC(=O)C2=CC=3C=COC=3C=C2F)C1)C(F)=CC4=CC=CN=C4 CC(C)(CCNC(=O)C1=CC(F)=C[NH1]1)NC(=O)C2CC(C(C)(C)C)C2 CC1=NC(C2CC2)=NC=C1C(=O)NCC[C@@H1](C)NC(=O)/C=C/[C@@H1]3CCCN3C CC=1C=CC(=O)N(CC(=O)N2CCC[C@H1]2[C@@H1]3CCCN3C(=O)C4=CC(Cl)=CS4)N=1 CN1C=NN(CC(=O)N2CCO[C@@H1](CC(=O)NCC3=NC(Cl)=N[NH1]3)C2)C1=O CC(C)[C@H1]1C[C@@H1](CC(=O)N[C@@H1]2CN(C3=CN=C(F)C=N3)CC4(CCC4)C2)CCO1 COCCN(CC(=O)N1CC(=O)NC(=O)[C@@H1]1C)C(=O)/C=C/C(C)(C)C CC=1OC(CO)=CC=1C(=O)N[C@@H1]2CCN(C(=O)C3=CN4N=CC=CC4=N3)C[C@@H1]2F C=CCNC(=O)CSCC1=NC([C@@H1]2CCCN(C)C2)=NO1 CCN(CCCNC(=O)[C@H1]1CCCN(C)C1)C(=O)C2(CN(C)C)CC2 CCCCC1(C(=O)NC[C@H1]2CCCN(C(=O)[C@H1]3CCCCCS3(=O)=O)C2)CC1 C[C@H1](O)C(=O)N1CC[C@@]2(CO[C@@H1](CNC(=O)C3(O)CC3)C2)C1 CN(C)C(=O)[C@@H1]1C=CCN1S(=O)(=O)C2=CC=C(N3CCC(C)(C)C3)N=C2 COCC(C)(C)C(=O)N1CCC[C@]2(CCN(C(=O)CC3=CN=NS3)C2)C1 COC1=CC=CC(CC(=O)N(CCCNC(=O)[C@@H1](O)C2=CC=CC=C2)C3CC3)=C1 C#C[C@H1]1CN(C(=O)CC2=CSN=N2)CCN1C(=O)C3=CSN=C3OC O=C([C@@H1](F)C1CC1)NCC2CCCCN(C(=O)C(F)(F)C3=CC=C(Cl)C=N3)C2C CC1(C)CC(F)(F)CC[C@H1]1OC(=O)C(C)(C)CSC2=NC3=CC=CC=C3S2 CC1=CC=C(CC(=O)N2C[C@@H1](O)C[C@@]2(C)C(=O)NCC3=NC=NN3C(C)C)C=C1 C=C(I)CC(=O)N[C@H1]1C[C@H1](CNC(=O)C2(C)CC2)C1 C[C@H1](CNC(=O)C1=CN=CC([N+1](=O)[O-1])=C1)N(C)C(=O)C2=NC=C(C#N)C=C2Cl CCOCCOCCC(=O)N1CC2(C1)OC3(C)CC2(NC(=O)CSCC(N)=O)C3 CC[C@@H1]1CN(C(=O)C2=C(C)C=C(OC)C=C2C)C[C@@H1]1NC(=O)CC(C)(C)OC CCN(C(=O)C1=CC=CC(N)=C1F)[C@@H1]2CCCN(C(=O)C3=C(F)C=NC=C3Cl)C2 CC(=O)NC1=CC=CC(C(=O)NC[C@@H1](C)N(C)C(=O)CCCC2CCOCC2)=C1 CS(=O)(=O)C1=CN=CC(C(=O)N[C@H1]2C[C@@H1](NC(=O)CC3=CC=CC=C3Cl)C2)=C1 CCC1=C[NH1]N=C1C(=O)N2CCC[C@H1](NC(=O)C=3SC=CC=3C(F)F)C2 C[C@@H1]1CC[C@H1](CC(=O)NC[C@H1]2C[C@H1]3CC[C@H1]2N(C(=O)C4(F)CCCC4)C3)C[C@H1]1C CC1=CN2C(=N1)C[C@@H1](C(=O)NC3(C)CCC(NC(=O)C4(O)CCC4)CC3)CC2 CCN(CCC(=O)N1CCC[C@@H1]1CN(C)C)C(=O)C2=CC(F)=C[NH1]2 COC(C)(C)CC(=O)N(C)[C@H1]1CCN(C(=O)[C@@](O)(C=2C=N[NH1]C=2)C(F)(F)F)C1 CCO[C@]1(C(=O)NC23CCC(C(=O)N[C@@H1](C)C4=NN=CN4C)(CC2)C3)CCOC1 CCOC1=CC=NC(N2CCC[C@@H1]([C@H1]3CCCCN3C(=O)CC4CC=CC4)C2)=N1 C=C1CCC(C(=O)NC[C@H1](CO)NC(=O)C2=CC(O)=NC(C3CC3)=C2)CC1 CC1=CN=C(C(=O)N[C@@H1](CNC(=O)C2=COC(C(C)C)=N2)C(C)C)C=C1Cl CC1(C(=O)NC2[C@H1]3C[C@H1]2CN(C(=O)[C@H1]4[C@H1]5CC[C@H1]6[C@@H1](C5)C[C@H1]64)C3)CC1 COCC[C@@H1](C)C(=O)NCC1(CNC(=O)[C@H1]2CC3=CC(F)=CC=C3C(=O)O2)CC1 COCC12CC(C(=O)N3C[C@H1](C)N(C(=O)C4=CC=NC(C)=C4O)C[C@H1]3C)(CO1)C2 C[C@@H1](C[C@@H1](C)NC(=O)CC1=CCN(C(=O)C2=CN=CC=C2C#N)CC1)C(F)F O=C(CC1=CCOCC1)NC2CC3(C2)C[C@@H1]3NC(=O)C4=CC(F)=CN=C4O CC(=O)C[C@H1](C)NC(=O)[C@H1](CC(C)C)NC(=O)OC(C)(C)C CC1CCC(C)(C(=O)N[C@H1]2CCN(C(=O)C3(CC4CC4)CC5(CCC5)C3)C2)CC1 COCC1(C(=O)NC2CC(CNC(=O)C3=CC(C(C)=O)=C[NH1]3)C2)CCC1 C=CCC1=CN(CC[C@H1]2CCCN(C(=O)[C@@H1]3C4C[C@@H1]5C3[C@@H1]5C4)CC2)N=N1 CCN1CCC[C@H1](NC(=O)[C@@H1]2CCCN2C(=O)CC(C)(C)C(=O)OC)C1 CC=C[C@H1](O)C(=O)N[C@H1]1CC[C@H1](NC(=O)C=2C=CC(=O)N(C)C=2)CC1 CC1=CC2=C(C(C(=O)N[C@H1]3CC[C@H1](NC(=O)C4=CC=NN4C)C3)=C1)CCC2 CNC(=O)N1CC(C(=O)N2CC[C@](O)(CNC(=O)C3=C(C)N=C4SC=CN34)C2)C1 C[C@H1](O)C1=NC=C(C(=O)NC[C@H1]2CN(C(=O)C3=NC=C(F)C=C3N)CC[C@H1]2C)S1 COCC=1C=C(C(=O)N[C@](C)(CO)CNC(=O)C[C@H1]2CCC(C)(C)CO2)ON=1 CSC1=CC=C(F)C=C1CNCC2=CC=C(O)C=C2C(F)(F)F COC(=O)[C@H1](C)CC(=O)N1C[C@H1](C)O[C@H1](C(=O)NCC2(OC)CC2)C1 COC1=CC=C(CN2CCS[C@H1](C(=O)NCC=3C(C)=NOC=3C)C2)C(C)=C1 C[C@H1](N=[N+1]=[N-1])C(=O)N1CC(F)(CNC(=O)[C@]2(C)CCCC[C@@H1]2C)C1 C[C@@H1](C1=C(F)C=CC=C1F)N(C)C[C@H1]2CCCCN2C(=O)CN3N=CC=C3N CC(C)(CC(F)F)C(=O)N1CCN(C2=CC=CC=C2C#N)CC1 CC1=CC(C)=NC(CN(C)C(=O)CC(C)(C)N2C=C(CC3CCOCC3)N=N2)=C1 CC=1C=CN(CC(=O)N2C[C@@H1](C(=O)NC3=CN=NC=C3C)C[C@@H1](F)C2)N=1 CC=1SC=CC=1C(=O)NC[C@H1]2CCCN2C(=O)C3=CSC(C4=CC=CC=C4F)=N3 C=CC[C@H1](CNC(=O)C1=CN=C(C)O1)NC(=O)C=2SC([C@@H1]3CCCO3)=NC=2C C[C@H1](CN(C)C(=O)C=CC1=NC=C[NH1]1)N=C2[NH1]C(C3=CC=CC(Cl)=C3)=NS2 CC1=CC(C(=O)NC[C@@](C)(O)CNC(=O)C2=CC=C3C(=C2)[C@H1](C)[C@H1](C)O3)=NN1C COCC(C)(C)N[C@@](C)(C1=NN=NN1C[C@@H1]2CCCO2)C3(OC)CCOCC3 COC(C)(C)C1(C(=O)NCC2=CSC(C(=O)N=C3C=CN(CCCO)[NH1]3)=C2)CC1 CCO[C@@H1](C)C(=O)NCC[C@@](C)(CC)NC(=O)C1=CN(C)N=C1OC CCSCC(=O)NCC1=CC=C(C[C@H1](C)NC(=O)[C@@H1](O)CN(C)C)C=C1 CCCC[C@H1](C(=O)NC1(C(=O)N[C@H1]2C[C@H1]3CCCCC[C@@H1]23)CC1)C(C)C CN(C1=NC(COC2=CC(F)=CC(F)=C2)=NC3=C1CCC3)[C@@H1]4CCC[C@H1](N)C4 O=C(C1=CC=C2C(=C1)OCO2)N3CC[C@H1](CCNC(=O)C4(Cl)CC4)C(F)(F)CC3 CN(C(=O)[C@H1]1CC12CCOCC2)C3CC(NC(=O)C4=CC5=C(N=N4)CCOC5)C3 CC(C)CS(=O)(=O)N1CCC2(CC(C(=O)N[C@H1](C)C3CCC3)C2)C1 CC1(CONC(=O)[C@@H1](NC(=O)C(=O)NCC(F)F)[C@H1]2CCOC2)CC1 CC[C@H1](C)[C@H1](O)C(=O)NCC1CCN(C2=NC(C(F)(F)F)=NC=C2Cl)CC1 COC1=NOC(C)=C1C(=O)NCC[C@H1]2CN(C(=O)CN3N=C(C)C=C3C)CCO2 CSCC1(C(=O)N[C@H1](CO)[C@H1](C)NC(=O)C2=CC3=CN=CC(C)=C3S2)CC1 C#CCC[C@H1](NC(=O)[C@@H1](C)N1CC(C)C1)C(=O)NC[C@@H1]2COC(=O)N2 C=CCCOCC(=O)N1CC[C@H1]2CCN(C(=O)CCS(=O)(=O)C3CCCC3)[C@H1]2C1 CCN(CCNC(=O)C1=CN2C=CC(C)=CC2=N1)C(=O)COC=3C=NN(C)C=3 COCC1=CSC(C(=O)N2CCCN(C(=O)C[C@H1]3CCCCC3(C)C)C[C@H1]2C)=C1 C[C@H1](OC1=CC=CC=C1)C(=O)NCCCC2CCN(C(=O)C3CSC3)CC2 C#CCCCC(=O)N1CC[C@H1](CN(C)C(=O)C2=CC3=CC=C(Cl)N=C3S2)C1 CC=1N=C(C2=CC=CC(Cl)=C2)SC=1C(=O)NC[C@H1](O)CNC(=O)[C@@H1]3C[C@H1]3C(C)C O=C1CC(C(=O)N2CC3(CN(C(=O)CC45CCC(CC4)C5)C3)C2)CC(=O)N1 CN(CC(=O)N(CCCNC(=O)C=CC(=O)N(C)C)CC1CC1)C2CCC2 CC1=CC(CNC(=O)[C@@H1](NC(=O)C2=CC=NN2C)C3=CC=CS3)=NN1C CC1=NC(C(=O)N2CCO[C@]3(CCN(C(=O)C4=CCC[C@@H1]4C)C3)C2)=NN1C CCC(CC)[C@@H1](F)C(=O)NCC[C@@]1(C)CCN(C(=O)C2=NC=CN=C2N)C1 CC1CN([C@H1](C)C(=O)N2CCN(C(=O)CCN3CCCCC3)[C@H1](C(C)C)C2)C1 C/C=C/CCCNC(=O)[C@@]1(NC(=O)C[C@@H1](CC)C2CC2)C[C@H1]1C CCC[C@@H1](OC)C(=O)N1[C@H1]2CC[C@@H1]1C[C@H1](NC(=O)C3=CN=C4C(=C3)CCCC4)C2 CC(C)(C)OC(=O)CC(=O)NC[C@H1]1C[C@H1]2CC[C@H1]1N(C(=O)[C@H1](F)CC3CC3)C2 COC[C@H1](OC)C(=O)NCC[C@@H1](C)NC(=O)C1=C[NH1]C2=CC=C(Cl)C=C12 CC1=CC=CC(C(=O)N2CCN(C(=O)C3=CC(Cl)=CS3)C[C@H1]4CCCC[C@@H1]42)=C1N CCC=1N=C2SC(C)=CN2C=1C(=O)N[C@H1]3COCCN(C(=O)[C@H1]4CNC(=O)C4)C3 C[C@H1](NC(=O)[C@H1](O)CN(C)C)C1CC(NC(=O)CC2(O)CCCCC2)C1 O=C1[C@H1](OC2=CC=C(OC(F)F)C=C2)CCN1C3=CC=CC=C3Cl O=C(NOCCOCCF)[C@H1]1C=CCCN1C(=O)C=2C=COC=2 CC1=CN=CC(/C=C/C(=O)N2CC[C@@H1](CNC(=O)C[C@@H1]3C=CCC3)C24CC4)=C1 CCCC(=O)N1C[C@@]2(CNC(=O)[C@H1]3CC34CCCCCC4)C[C@@]2(C(F)(F)F)C1 O=C1NC[C@@H1](NC2C[C@@H1]3CC[C@H1](C2)O3)C[C@@H1]1O CO[C@H1](C)[C@@H1](C(=O)N1CC[C@@H1](NC(=O)C2=CC=C(C)N=C2)CC(C)(C)C1)N(C)C C[C@@H1]1C[C@H1]2CN(C(=O)C[C@@]34CCC[C@@H1]3C4)C[C@H1]2N1C(=O)C5=CN=NC(O)=C5 CC1(C)CN(C(=O)C2=CN=C3C(=C2)CCC3)CC[C@@H1]1NC(=O)CCCC(N)=O CCC[C@@H1](CC)C(=O)N1CC[C@](COC)(NC(=O)C2=CC=C(F)C(SC)=C2)C1 CC1=CC=CC=C1CC(=O)N(C)C[C@@H1]2C[C@H1](F)CN2C(=O)C=3C=NN(C(C)C)N=3 COC(=O)[C@@H1](C)C(=O)N1C[C@@H1](NC(=O)C2(CC(C)C)CC2)C[C@@H1](C)C1 CCC1=CC=CC(NC(=O)C[C@@]2(C)CCN2C(=O)C3=NN=C(O)N=C3O)=C1 CCOC(=O)NCC(=O)N1CCCC[C@H1]1CCNC(=O)CC=2C(C)=NN(C)C=2Cl CC[C@@H1](C)/C=C/C(=O)N(CC)CC1CCN(C(=O)C2=C(C)C=C(C)C=C2C)CC1 CCCCN1N=NN=C1[C@@H1](NCC2=NN=C3N2CCOC3)C4=NC=C(Cl)S4 CC[C@@H1](O)C(=O)N(C)[C@@H1](C)CCNC(=O)CC1=CC=NC=C1Cl CN(CC1(NC(=O)CCN2CCOCC2)CC1)C(=O)C3=CC=CC4=C3OCCO4 CC1=CC=C([C@H1]2CNCCN2C(=O)C=3N=NN(C(C)C)C=3C)C=C1 CCC(=CC(=O)N1CC2(CC2)C[C@H1]1C(=O)N[C@@H1]3CCN(C(C)=O)C3C)CC CCCC1=CC=C(N)C(C(=O)N[C@H1](C)CCNC(=O)CN2C=CN=N2)=C1 CN(CC1=NC=C(Br)C=N1)S(=O)(=O)C2=CC=C(NCC3=CC(Cl)=CC(Cl)=C3)N=C2 CC(C)(F)CCC(=O)N1C[C@H1]2CN(C(=O)CC3=CN=C4C=CC=NN34)CC[C@H1]2C1 C[C@H1](NC(=O)C(=O)N(C)CCC1=NC(C2=CC=CC=C2)=NO1)[C@H1]3COCCO3 CC[C@@H1](C)CCC(=O)NC1CCN(C(=O)C2(C)CC(C)C2)CC1 COC1=CC=C(OCC(=O)N(C)C2CCN(C3=NN=CS3)CC2)C=C1 CC(C)N1N=CC=C1CN2CCC[C@@H1]2CC(=O)NC3=CC=C4N=C[NH1]C4=C3 CC1=CN=C(F)C(C(=O)N2CC[C@H1]2CNC(=O)C=CC3=CN=CC(F)=C3)=C1 COC[C@H1](OC)C(=O)NCCCCCNC(=O)[C@@H1]1CCS(=O)(=O)C2=CC=CC=C21 COC1=CC=CC(C(=O)N[C@H1]2CN(C(=O)C3=C(C)N=C(O)N=C3S)C[C@H1]2C)=N1 CCC(=CC(=O)NC1C[C@]2(CC[C@@H1](NC(=O)[C@H1](O)CCSC)C2)C1)CC O=C(N[C@H1]1CC12CCC2)C3=CC=C(CNC(=O)C4=CC5=CN=CC=C5[NH1]4)C=C3 C[C@H1]1C[C@]1(C#N)C(=O)N2CCC(N(C)C(=O)CCC3=CC=CC(F)=C3F)CC2 CC(C)(CNS(=O)(=O)C1=CC=C(NCCC2CCOCC2)C(F)=C1)C(F)(F)F CCC=CC(=O)N1CC[C@H1](C)[C@@H1](NC(=O)CCOC2=CC=CC(C)=C2C)C1 CC1=CC=C(N2N=C(CN3C=CC=N3)N=C2C[C@@H1](C)CBr)C(C)=C1 O=C(CC1=CC=CC(O)=C1)N[C@@H1]2C[C@H1]3C[C@@H1]2CN(C(=O)C4=CC(F)=C[NH1]4)C3 C[C@@H1]1CN(C(=O)COC2CC=CC2)CC[C@H1]1CNC(=O)C3=CC(F)=C(N)C(F)=C3 CC=1OC(CO)=CC=1C(=O)N(CCO)CCCNC(=O)C(F)(F)CC2CC2 C=CC=CCC(=O)N1CCC2(CC2)C[C@@H1]1C(=O)NCC3=CSC=N3 C[C@H1](C(=O)N[C@]1(CNC(=O)C2=CN=CC(C(N)=O)=C2)CCOC1)C=3C=CN(C)N=3 CC[C@@H1](C(=O)NCC[C@H1](C)NC(=O)CN1CCCCC1=O)C2=CC=CN=C2 O=C([C@H1](S(=O)(=O)C1COC1)C2=CC=CC=C2)N3CCC[C@H1](N4CC[C@@H1](O)C4)C3 CC(C)CS(=O)(=O)N1CCCC[C@H1](NC(=O)C2=CC=CC(C#N)=C2)C1 C[C@@H1]1CC2(CC2)CN1C(=O)[C@H1](NC(=O)CC[C@H1]3CCCCO3)C4CCC4 C=CCC(C)(C)CC(=O)N[C@@H1]1CCN(C(=O)[C@H1](C)OC(C)(C)C)C1(C)C CN1N=NN=C1[C@@]2(NCC3=CC=NC=C3F)C[C@H1]4CCCCC[C@H1]4C2 CC=1N=C(C2=CN(C[C@H1](CC(C)C)NC(=O)[C@@H1](O)CCC(F)(F)F)N=N2)SC=1C CC1(C)CCN(CCCN=C(NCC2=NN=C(C3CC3)S2)N[C@@H1]4C[C@H1]5CC[C@H1]4C5)C1 CCC(CC)N1N=CC=C1C(=O)N[C@H1](CNC(=O)[C@@H1](CO)C(C)C)CC(C)C CCC1(CC)CCN1C(=O)[C@@]2(CNC(=O)C3=NC=CN=C3C)CCCO2 C[C@@](CO)(CNC(=O)CC1=CC=CC2=NON=C12)CC3=CC=CS3 C[C@H1](C(=O)N[C@@H1]1C[C@H1]1CNC(=O)C2(C3=CC=CC(Cl)=C3)CC2)N4CCC4 CC1=CN=C(C(=O)N2C[C@@H1]3CC[C@H1](C2)N3C(=O)[C@H1](C)[C@H1](C)O)C=C1C C[C@@H1](C(=O)N1CCC[C@H1](N2C=C(CNC(=O)C3=CN=CC=N3)N=N2)C1)S(C)(=O)=O C[C@H1](CC(=O)NC[C@H1]1CC[C@@H1](NC(=O)C2=CN(C)N=C2Cl)C1)C(F)(F)F COC1=CC=C(F)C([C@H1](N[C@H1](C)CCO)C2=NN=NN2CCCSC)=C1 COC1=C(NS(=O)(=O)CC(=O)N(C)C)C=C(Br)C=C1C(N)=O COC[C@](C)(CN1C=C([C@@H1](CC(N)=O)NC(=O)CSC)N=N1)COC CC1=CC(=O)C=CN1CC(=O)N[C@H1]2CCN(C(=O)[C@H1]3CCC4=NC=CN4C3)[C@H1]2C CC[C@H1](O)CCNC(=O)[C@@H1]1CN(C(=O)C2=C[NH1]C(=N)O2)C[C@H1]1OC O=C1C[C@@H1](C(=O)N[C@@H1]2C[C@@H1]3C[C@H1](NC(=O)C4=CC=CC=C4Br)C[C@@H1]3C2)CO1 COC1=CC=CC(C[C@H1](N)C(=O)NCCCC(=O)N2CCC=3SC=CC=3C2)=C1 CC1=CC=C(C(=O)N[C@H1]2CC[C@H1](C)N(C3=NC=C(Br)C=C3C#N)C2)N=C1 C[C@@H1](SC1=CC=CC=N1)C(=O)N2CC(CN3C=C(C(C)(C)CO)N=N3)C2 C=CCCC[C@H1](C)[C@](C)(NC1=CC=C(OCC)N=C1)C2=NN=NN2C(C)C O=C(N[C@H1]1C[C@@]2(CO)CO[C@H1]1C2)C=3C=C(C4=CC=CS4)[NH1]N=3 CCC[C@H1](CCCNC(=O)C1=NC(C)=NC=C1Br)NC(=O)C=2C=C(C)OC=2C CC#CCCCC(=O)N(CCC)[C@H1](C)C(=O)NC1CC(C2CC2)C1 CC1=CC=C2C=C(C(=O)N3CC=C(C4=CC=CC=C4)C3)C(C)=NC2=C1 O=C(CCC1=CN=C2N1CCCCC2)N[C@H1]3C=CCN(C(=O)C4(CCO)CC4)C3 COCC[C@@H1](NC(=O)C(=O)C1=C[NH1]C2=CC=CC=C2C1=O)C3=CC=CC(Br)=C3 CC(C)(C)C[C@@H1]1CCN1C(=O)[C@H1]2C[C@@H1](CNC(=O)CC[C@@H1]3CCCO3)C2 C[C@H1](CN1CC(CNC(=O)C=2C=CSC=2)C1)CC(C)(C)C C[C@H1](O)C1=CC=CC=C1NC(=O)C2=N[NH1]C=C2NCC3=CC(F)=C(Cl)C=C3Cl CC(C)N(CCNC(=O)[C@@H1]1C[C@H1]2CCC[C@H1](C2)C1)C(=O)C3CC4(C3)C[C@@H1]4F CN1C=C(C(F)(F)F)N=C1C(=O)N[C@@H1]2COC[C@H1]2CNC(=O)CCNC(N)=O CCOC(=O)[C@H1]1[C@H1](CC)CCN1C2=NC=NC3=C2N=CN3C[C@@H1](COC)C(F)F COC[C@]1(C(=O)N2CC[C@H1]3CC[C@H1]32)C=CCN1C(=O)[C@H1]4CC(C)(C)CO4 C[C@@H1]1CC=CC[C@@H1]1[C@@H1](C(=O)NCCCC2CC2)N3CC[C@H1](COC4=CC=CC=C4)C3 CC[C@@H1](CC(=O)N1C[C@@H1]2C[C@H1]1[C@@H1]2CNC(=O)CCCSC(C)(C)C)CC(F)(F)F CC(=CN1C=CN=N1)C(=O)N2C[C@H1](O)C[C@@H1](NC(=O)CSS(C)(=O)=O)C2 CN1CCN([C@@H1]2CCN([C@H1](C(=O)NC3CCOCC3)C=4C=N[NH1]C=4)C2)CC1 COC(=O)[C@@](C)(F)C(=O)N1C[C@H1](F)[C@H1](NC(=O)C2=CC(C)=C(Cl)C=C2F)C1 O=C(/C(Cl)=C/Cl)N1CCN(C(=O)C=2C=COC=2C(F)(F)F)C[C@H1](O)C1 C#CC[C@@H1](C)C(=O)N1CCC(CNC(=O)C2=CC=C3N=C4N(C3=C2)CCC4)CC1 CC1=NC=C(C(F)(F)F)C=C1C(=O)NCCOCCN(C)C(=O)[C@]2(Cl)CC23CCC3 CO[C@@H1](C(=O)N[C@@H1]1C[C@@H1](O)[C@@H1](CNC(=O)CCC2CCCCCC2)C1)C(C)(C)C CCCCS[C@@H1](C)C(=O)N[C@H1]1C[C@H1]2C[C@@H1](NC(=O)CCCC(=O)N(C)C)C[C@H1]2C1 NC(=O)N1CCC[C@@H1](C(=O)N2[C@H1](CNC(=O)C3=CN=CC=C3Cl)C[C@@H1]4C[C@@H1]42)C1 O=C(CCCN1C=NC=N1)NC2([C@@H1]3CCCN3C(=O)CCN4CCOC4=O)CC2 CC(C)C1=NOC=C1C(=O)NCCCCCCN(C)C(=O)[C@@]2(C)CC=CCC2 CC1=CC(C(=O)N2CCN(C(=O)C=C[C@@H1]3CCOC3)C[C@@](C)(F)C2)=C(F)C=C1F CCC[C@H1](CC(=O)NCC1=CC(C)=CC=C1O)NC(=O)C[C@@H1]2CCO[C@H1]2C COC1=CC=C2[NH1]C=C(CNC[C@H1]3C[C@H1]3CO)C(C)=C2C=C1OC CC(C)[C@@H1](O)C(=O)NCC1(C(N)=O)CN(C(=O)C2=CC3=C(S2)CCCC3)C1 CC[C@@H1]1[C@@H1](CC(=O)N[C@H1]2C[C@@H1]3C[C@H1]2[C@H1](NC(=O)C4SCCCS4)C3)C1(F)F C[C@]1(C(=O)NC[C@@H1]2CCCN2C(=O)C3=C[NH1]N=C3[N+1](=O)[O-1])C[C@H1]4CC[C@H1]1C4 CC=1N=C(N2C=C([C@H1](C)N(C)C(=O)CCC3=CN=C[NH1]3)N=N2)SC=1C C[C@@H1](CCN(C)C(=O)C1=CC=C(O)C(Cl)=N1)NC(=O)C2=CC3=CC=C(Cl)C=C3O2 CC(C)N(CCNC(=O)[C@@H1]1CNC[C@H1]1CC2CC2)C(C)C C[C@]1(O)C[C@@H1](C(=O)NC[C@]2(O)CCCN(C(=O)C3=CC=C(Br)C=C3F)C2)C1 CCC1=CC=C(C(=O)N2C[C@H1]3C[C@]3(C(=O)N(C)C)C2)C=C1 CC(C)CC(=O)N1CC[C@@H1](C(=O)N(C)C[C@H1]2CCOC2)C1 C[C@H1](C#N)CCC(=O)N1CCC[C@@H1]1CNC(=O)C2=CC=C3C=NOC3=C2 CCC1=NC2=CC=CC=C2C(C(=O)N[C@H1](C)CN(C)C(=O)C3=CC(O)=NC=N3)=C1 C[C@@H1]1CC=CC[C@H1]1C(=O)N2CC(NC(=O)C3=C[NH1]C(=N)N=C3C(F)(F)F)C2 CNC(=O)[C@@H1](C1=CC=C(OC(F)(F)F)C=C1)N2C[C@H1](C3(O)CCC3)C24CCC4 CN(CC(C)(C)CNC(=O)C(F)=CC1=CC=CN=C1)C(=O)[C@H1]2CCCS(=O)(=O)N2 C[C@@H1]1C[C@@H1](C(=O)N[C@H1]2CCN(C(=O)C=3C=C(CF)ON=3)[C@@H1](C)C2)CCS1 C#CCCCCC(=O)N1CC[C@]2(NC(=O)C3=C(CC)OCCC3)CCCC[C@@H1]12 C=C=CCCC(=O)NC[C@H1](F)C1CCN(C(=O)C2=CC=CC(OC3CC3)=C2)CC1 O=C(CCN1C=CC(O)=NC1=O)NC[C@H1](O)CNC(=O)[C@@H1]2CCCS2(=O)=O O=C(NCCC1CN(C(=O)/C(Cl)=C/Cl)C1)C2=CC=NC=3[NH1]C=NC2=3 CC[C@@H1](O)[C@@H1](C)C(=O)NC1(CO)CN(C(=O)C2=NC(C)=C(C)S2)C1 C[C@@H1](CNC(=O)CC[C@H1]1CCCOC1)CNC(=O)C#C[C@@H1]2CCOC2 CSCCCC(=O)N[C@H1](CC(=O)N1CCNC(=O)C[C@H1]1C)C(F)(F)F CC=1C=NOC=1C(=O)NCC[C@H1]2C[C@H1](NC(=O)C[C@H1]3CCC4=CC=CC=C43)C2 C[C@@]1(C(=O)NC[C@@H1](O)CCNC(=O)CCC2=CC=CC=C2F)C[C@H1]3CC[C@@H1]1O3 CC1=NC(CC(=O)N2C[C@@H1]3CC[C@H1](C2)N3C(=O)[C@@H1]4CC[C@@H1]5[C@H1](C4)C5(F)F)=N[NH1]1 CN(CC1(C)CCCC1)C(=O)CCCC(C)(C)NC(=O)C2CCC=CCC2 O=C(NCC[C@H1]1CCCN(C(=O)[C@@H1]2CCCOC2)CC1)[C@@H1]3CCCCC(F)(F)C3 C[C@H1](CO)C(=O)NC[C@H1]1CC[C@H1](NC(=O)C2=CC=CC=C2N3C=NN=N3)CC1 CN(CC(=O)NC[C@@](C)(CO)NC(=O)C1=CN=C(C(C)(C)CF)O1)S(N)(=O)=O CC[C@H1](C)C(=O)NC[C@@]1(NC(=O)CC2=CC=C(C#N)C=C2F)CCOC1 CCOCCS(=O)(=O)N1C[C@H1]2CCN(C(=O)[C@@H1](C)C3=CC=CS3)C[C@H1]2C1 CS(=O)(=O)CCCNC(=O)[C@H1]1C[C@H1]2CC[C@@H1]1N2C(=O)C3=CC=C(C#N)C=C3 CCCCC=1C=C(NC[C@@]2(O)CCOC(C)(C)C2)N3N=CN=C3N=1 CC(C)N(CC=1C=NN(C)C=1)C(=O)[C@@H1]2C[C@@H1]3C[C@H1]3N2S(=O)(=O)CC4=CC=CC=C4 CC[C@@H1](NC(=O)[C@@H1](C)C1CCN(C(=O)CC2=CSN=C2C)CC1)C3=CC=CS3 C[C@H1](CC1CC1)C(=O)N(C)C2C[C@@H1]3CC[C@H1](C2)N3C(=O)[C@H1]4CC5=CC=CC=C5O4 CC1C=CN=C(C(=O)N[C@@H1]2CCC3=CC(CNC(=O)[C@H1](C)C#N)=CC=C32)N=C1 C=CCCCCCCC(=O)N1CC=C[C@@]1(C)C(=O)N(C)C2CC(O)C2 CO[C@H1]1CCC[C@@H1]1C(=O)N(C)C[C@H1]2CCCN2C(=O)C3=CC([N+1](=O)[O-1])=C[NH1]3 CC1=NSC(C(=O)N2CC[C@](C)(CNC(=O)[C@@H1](C)C3=CC=NC=C3C)C2)=C1N O=C([C@@H1]1CCCCO1)N2CC[C@H1]3C[C@@]3(C(=O)NC[C@@H1]4CCC(=O)O4)CC2 C[C@@H1]1CCN(C(=O)[C@@H1]2CCC[C@H1](C#N)C2)[C@@H1]1C(=O)N(C)CCOCCCO CCC1=CC(F)=CC=C1CC(=O)NC2CCC(C)(CNC(=O)[C@H1](C)COC)CC2 CCN(CC)C(=O)C1=CC=C(C(=O)N[C@@H1](CNC(=O)C2=CCCC2)C3CC3)C=C1 CCC[C@H1](NC(N)=O)C(=O)N1CC[C@H1]2CCN(C(=O)CC3=CN=CN=C3O)C[C@@H1]21 CNC1=CC=CC(C(=O)N[C@@H1]2CCC3=C(F)C=C(F)C=C32)=C1 C[C@@H1]1C[C@H1](NC(=O)C2=C(F)C=CC=C2F)CN1C(=O)C3=CN=NC=C3O CSC1=CC(N[C@@H1](C2=CC=C(C(F)(F)F)C=C2)C3=NN=NN3C4CCC4)=NN1C COCC1(C(=O)NC2=CC=C(COCCO)C=C2)CCCC1 CC(=O)N[C@H1](C(=O)N[C@H1](CO)CNC(=O)CS(=O)(=O)N1CCCC1)C2CCCC2 [N-1]=[N+1]=NCCCC(=O)NC[C@@H1]1CC[C@H1]1NC(=O)[C@@H1]2CNC(=O)C2 CC1=CC(C(=O)NC[C@H1](CNC(=O)C=CC2=CC=NC=C2)C3=CC=CC=C3)=CS1 CC1=NO[C@](C(=O)N[C@H1]2C[C@@](C)(NC(=O)C3=CCCCO3)C2)(C4=CC=CC=C4)C1 O=C(NCC1CN(C(=O)[C@H1]2CCCN2C3CCCC3)C1)[C@@H1]4CCCS4 CC1(C)CC(CO)(C(=O)N2CC=C[C@@H1](NC(=O)[C@H1]3CC4=CC(F)=CC=C4O3)C2)C1 COC1(C(=O)N(C)C[C@H1](O)CN(C)C(=O)[C@@H1]2CC[C@H1]3C[C@H1]3CC2)CS(=O)(=O)C1 CC1=CC=C(C(=O)NCC2=NO[C@H1]3CN(C(=O)CC4=CN=CN=C4)C[C@H1]23)C(C)=C1 CC[C@H1](C(=O)N[C@@H1](CNC(=O)C1=C[NH1]C2=CC=C(Cl)C=C12)C3CC3)C(C)C CC1=CC=C(C(=O)N2CC3(CCN(C(=O)C4=CC=C(Br)C=C4)C3)C2)N=C1C CCN(C)[C@H1]1C[C@@H1](C(=O)N2CC[C@@](CF)(C(=O)N[C@@H1](C)C3=NC=C[NH1]3)C2)C1 CCC=C(C)C(=O)N[C@@H1](C)C1(C(=O)N2CC(C#N)C2)CC1 O=C(NCCN(C(=O)[C@H1](F)CC1CC1)C2CCCCC2)[C@@H1]3CCC4=NN=CN4C3 COCCN1C=NN=C1CNC(=O)[C@H1]2C[C@H1]2C(=O)OCC3=CC=CC=C3C CC=1N=C(O)[NH1]C=1C(=O)N(C)C[C@@H1]2CCN(C(=O)C3=CCCCO3)C2 CC(C)(O)[C@H1](F)C(=O)NCCCNC(=O)/C=C/C1=CC=C(C2OCCO2)O1 CCC(C)(C)[C@H1](O)C(=O)NCC1CC(NC(=O)C2=CC(=O)C3=CC=NC=C3O2)C1 COC1(C(=O)N2C[C@H1](CO)C[C@@H1](F)C2)CCN(C(=O)C3=C(F)C(C)=NN3C)CC1 CC[C@@H1](C)C[C@@H1](NC(=O)C1=C[NH1]C(=N)O1)C(=O)NC2=CN=CC=C2CC COCCC[C@@H1](NC(=O)CNC(=O)OC)C(=O)N1[C@H1]2CSC[C@H1]1C2 COCC1=NC(NCCCN2CCC[C@@H1](C)C2)=CC(N3CCSC4(CCCC4)C3)=N1 C[C@@H1](F)CC(=O)N[C@@H1]1C[C@H1]2CC[C@@H1]1C[C@H1]2NC(=O)CC(C)(C)CN(C)C CCNC(=O)C(=O)NC[C@H1]1CC[C@H1](NC(=O)CCC=2C(C)=NOC=2Cl)CC1 CCC[C@H1](NC(=O)[C@H1]1CN(C(=O)C=C(C2CC2)C3CC3)CC14CC4)C5=CC=CO5 O=C1CC2(CCN(C(=O)C3(O)CCN(CC4=CC=C5C=CSC5=C4)CC3)CC2)C1 NS(=O)(=O)N1CCC(C(=O)N2CCN(C(=O)[C@@H1](O)C3CC3)C[C@@H1]2CO)CC1 C[C@@H1]1CCN(C(=O)OC(C)(C)C)[C@@H1]1CNC2=CC(OCCCN(C)C)=CC=N2 CC(C)C1=NN=NN1CC(=O)N[C@H1](CNC(=O)/C=C/[C@H1]2CCCO2)C(C)C C=CCN(C(=O)C1=CC[C@H1]2CC[C@H1]1N2C(=O)[C@H1]3CCN(C)C3)C4CCCC4 C[C@@H1]1C[C@@]1(F)C(=O)N2CCCC3(CN(C(=O)C4=CN(C)C=N4)C3)C2 CC1=CSC([C@H1](NC(=O)C(=O)N2CCC(C3=NC=CC=C3C)CC2)C4CC4)=N1 CCC1=CC=CC(CC)=C1C(=O)NC[C@H1]2CCCN2C(=O)COCC3CCCC3 CCN1CC[C@H1](C(=O)N2C[C@@H1](C)[C@@H1](NC(=O)CC3CCOCC3)C2)C1 CN1C(=O)COC2=CC=C(C(=O)N3C[C@@H1](C)[C@H1](CNC(=O)[C@H1](C)C#N)C3)C=C21 CC1=C(C(=O)NC(C)(C)CNC(=O)C2=CC=C(O)C(C(N)=O)=C2)SC3=NC=CN13 CCCN(CCNC(=O)C1=CNC2=CC=C([N+1](=O)[O-1])C=C12)C(=O)C3=CSC(O)=N3 C=CCCCC(=O)NC(C)(C)[C@H1]1CCN(C(=O)C2=CC=CC=C2C3CC3)C1 CN(CCN(C)C(=O)C[C@@H1]1CCCC=2OC(C)=NC=21)C(=O)CCCOC(C)(C)C COCCCNC(=O)[C@H1](C)N(C)CC1CCN(C(=O)C[C@@H1]2CCNC2=O)CC1 O=C(OCC1=NC=C(C2=CC=CC(Br)=C2)O1)[C@H1]3CCC4=NC(C5CC5)=NC=C4C3 CC[C@@H1](C(=O)NCC[C@H1]1CCCN1C2=NC=NC3=CC(C)=CC=C23)N4C=CN=C4 CCSCC(=O)NCCN(C)C(=O)[C@@H1](CCOC)NC(=O)OC(C)(C)C C[C@]1(C(F)F)C[C@@H1]1C(=O)NCC2CN(C(=O)[C@H1]3CCC4=C(Br)C=CC=C43)C2 C[C@H1](C(=O)N[C@@H1]1CCN(C(=O)C2=CC=C(O)C(F)=C2F)CC1(C)C)C3=CC=CO3 CCOCCCCCC(=O)N1CCC[C@@H1]1[C@H1](C)NC(=O)CCO[C@H1]2CCOC2 COC1(C(=O)NC[C@@]2(O)CCN(C(=O)C3=NNC(=O)CC3)C2)CC(C(F)F)C1 C=CC1=CC=C(C(=O)NCC2=NOC=C2C(=O)NCCSCCO)C=C1 O=C(N[C@@H1]1C[C@@H1]2CN(C(=O)C=3N=C[NH1]C4=NC=CC=34)C[C@H1]21)C5CC(=C6CCC6)C5 N#C[C@@H1]1CC[C@@H1](CC(=O)N[C@]2(C(=O)N3CCC4=C[NH1]N=C4C3)CCSC2)C1 COC1=C(C(=O)N2CCC[C@]3(CCN(C(=O)CNC=O)C3)C2)C(C)=NN1C CC(=O)N(C)CCN(C)C(=O)[C@H1]1C[C@@H1](NC(=O)C2=NC=CN2C(C)C)C13CCC3 OC[C@@](F)CCNC1=NC2=C(C(N3CC[C@@H1](C4=CC=NC=C4)C3)=N1)CCCCC2 CN(CC1=CCSC1)C(=O)[C@H1]2CC[C@H1](O)CN2C(=O)CC3=CC=C(O)C=C3 CCS(=O)(=O)NC[C@]12C[C@H1]1CN(C3=NC(C)=NC=C3C#N)C2 CC[S@](=O)CC(=O)N[C@]1(C)CCN(C(=O)C2=CC=CC(OC(F)F)=N2)C1 COC(=O)C1(CCS(=O)(=O)NC[C@@H1]2CCN(C)[C@@H1]2C3=CC4=CC=CC=C4O3)CC1 CCC(=CC(=O)N1CC[C@@H1](CN(C)CC(=O)N(C)C2CC2)C1)CC CC1=NSC(CNC(=O)[C@H1]2CCCCCCN2C(=O)C=3C=C[NH1]C=3C)=N1 CC=1C=C(C(=O)N[C@@H1]2CCN(C(=O)C=3C=NC4=NC=CN4C=3)C2)SC=1Cl CCN1C=CC(C(=O)N2CCCO[C@@H1](CNC(=O)C3=CN=C(SC)N3C)C2)=C1C C=CCN1C=CC=C1C(=O)N2C[C@H1](CNC(=O)C3=NN(C)C=C3C)C4(CC4)C2 C[C@H1]1CC(CNC(=O)N2CCC(C3=CC=CC=C3Br)CC2)=NO1 CC1=CC=C(CNC(=O)[C@@H1]2CN(C(=O)[C@@]3(C)COCCO3)CCN2C)C=C1C O=C(C[C@H1]1CCCN(C(=O)C2=CC(O)=NC(O)=N2)C1)NCC3=NN=CS3 CC1(C)OCC(NC(=O)C2CC(O)(C=NO)C2)CO1 CO[C@]1(C)C[C@H1](NC(=O)C2(C)CC(NC(=O)[C@@H1]3CC(C)=NO3)C2)C1(C)C C[C@H1](OCCN(C)C)C(=O)N1CCOC[C@@H1]1CNC(=O)C2=CC=C(F)C(F)=C2F CC[C@@H1](C(=O)NC1C(C)(C)C(NC(=O)C=2C=NSN=2)C1(C)C)[C@H1](C)O C[C@]1(C(=O)N[C@H1]2C[C@@H1](CNC(=O)CCCN3C=CC=CC3=O)C2)CCCOC1 C=CC[C@H1](CNC(=O)[C@@]12CC[C@@H1](OC)[C@@H1]1C2)C(=O)N3C[C@@H1](F)C[C@@H1](F)C3 CCCC[C@@H1](CNC(=O)[C@@H1]1CCCN(C(=O)C=2C=CSC=2)C1)NC(=O)CCCC C=C1C[C@H1]1C(=O)N2CCCC[C@@H1]2CN(CC)C(=O)C3=CN=C(C)N=C3C CC(C)C[C@H1](CNC(=O)C1=CCOCC1)NC(=O)C2=CC(Cl)=CC([N+1](=O)[O-1])=C2O CC(C)(CNC(=O)C[C@@H1]1CC1(C)C)[C@@H1]2CCCN2C(=O)C[C@@H1]3CCC(=O)NC3 CC1=CC=C(/C=C/C(=O)N[C@H1]2CCN(C(=O)CC3=CC=C(C)C=C3)C[C@@H1]2CO)S1 CCCS(=O)(=O)[C@@H1](C)C(=O)NC[C@@H1](C)N(C)C(=O)C=CC1=NC=C(C)[NH1]1 CC[C@]1(O)CCN(C2=C(Br)C=NC=C2C3=CN=CS3)C1 CCN1C=CC(C(=O)N2CCC[C@H1](C(=O)NC3=CC=NN=C3OC)C2)=N1 C#CCC(C)(C)C(=O)NN1CCC[C@H1]1C(=O)N2C[C@H1](C)[C@H1](N=[N+1]=[N-1])C2 CO[C@H1]1C[C@H1](NC(=O)C=2[NH1]C=NC=2C)CN(C(=O)[C@]34CCCC(=O)N3CCC4)C1 C=CC[C@H1](CNC(=O)COC=1C=CSC=1Cl)NC(=O)[C@H1](C)C=2C=CSN=2 CCC1=CN=C(C(=O)N(C)CCN(C)C[C@H1](O)[C@H1](C)C2=CC=CC=C2)S1 CCCN(CCNC(=O)CCN1CCC1)C(=O)[C@@H1]2CCCN3C=NN=C32 O=C(CN1C=NN=C1)N[C@@H1]2C[C@@H1]3C[C@H1](NC(=O)C4=CC(Br)=CC=5N=C[NH1]C4=5)[C@H1]2C3 CC1=CC=C(C(=O)N[C@@H1]2CCCC23CN(C(=O)[C@]4(C)CCC(=O)C4)C3)C(F)=C1Cl CCC1=NC(C(=O)N2CC[C@@H1]([C@H1](C)C(=O)NC3CC(C4CCCC4)C3)C2)=CS1 CC1=CC=C(C(F)(F)C(=O)NCC[C@@H1](C)CCNC(=O)C2(CC(C)C)CCC2)S1 CCCN(C(=O)C1=CC=CC(CNC2=CC3=NN=CN3C(C)=N2)=C1)C(CC)CC CC=1[NH1]N=C(Cl)C=1C(=O)N2CCN(C(=O)C=3SC=C4C=3CCCC4)C[C@H1](CO)C2 COC(=O)CC1=CC=C(OCCOC(=O)CCN2CCCC3=CC=CC=C32)C=C1 O=C(NCC(F)=C1CN(C2=CC(CO)=CC([N+1](=O)[O-1])=N2)C1)C3=CN=C4N3CCC4 CCN(C)C1=CC=C(C(=O)N2C[C@@H1]3CN(C(=O)C=4C=C[NH1]N=4)C[C@]3(C)C2)C=C1 CN1C[C@](C)(C(=O)N(C)C[C@H1](O)CNC(=O)C2(C#N)CCC2)CCC1=O CC1=CC=C(N2[NH1]C(C(=O)N[C@@H1]3C[C@H1]3CNC(=O)[C@@]4(O)CCOC4)=CC2=O)C=C1 CC1=CC(C(=O)NC2C=C(C(C)(C)C(=O)NCC[C@@H1](O)CCO)C2)=CO1 NC(=O)NCCCC(=O)NC[C@H1]1CCC[C@@H1]1NC(=O)CCC2=CN=CO2 CC(C)(C(=O)N1CC[C@](C)(NC(=O)[C@@H1]2C[C@@H1]2F)C1)C3=CC(Cl)=CC=C3F C=CC[C@H1](C(=O)NCC[C@H1](C)NC(=O)C=1C=C(F)N(C)N=1)C(C)(C)C C[C@@](O)(C(=O)N[C@]1(CNC(=O)C=CC2=CC=CC(F)=C2)CCOC1)C3CCC3 CC[C@@H1]1[C@H1](NC(=O)C2=CN=NN2CC)CCCN1C(=O)C[C@@H1]3CCCN(C)C3 CC[C@H1](F)C(=O)NC[C@@H1]1C[C@@H1](NC(=O)C2=CC3=CC(C)=C(Cl)C=C3[NH1]2)CCO1 C[C@H1]1CC[C@H1](C)N1CC(=O)N2CCC(CNC(=O)C3=CC=CN4C=NN=C34)CC2 CC[C@@H1]1C[C@H1]1C(=O)N[C@@H1](C)C2CCN(C(=O)[C@H1](CO)NC(N)=O)CC2 CO[C@@H1]1C[C@H1](CNC(=O)C2CC=CC2)N(C(=O)CN3CCC(C)CC3)C1 CN(C[C@H1]1CCCN1C(=O)[C@H1](O)C2=CCCCC2)C(=O)CC34COCC(C3)C4 CCOC=1OC(C2=CC=CO2)=NC=1C(=O)N[C@@H1]3C[C@H1]3NC(=O)[C@H1]4CCCS4(=O)=O CCC1=CC=C2OC=C(C(=O)N[C@@H1](C)[C@@H1](CO)NC(=O)[C@@H1](C)OCCOC)C2=C1 O=C(CCC1=NC(C2CC2)=NO1)NC3(CCNC(=O)[C@@H1]4CC5CCC4CC5)CC3 O=C1CN(CC(=O)NC[C@@H1](O)CNC(=O)C=2C=C3N(N=2)CCCN3)C(=O)N1 CC(C)[C@@H1](CCN(C)C(=O)C=C(C1CC1)C2CC2)NC(=O)/C=C/[C@@H1]3CCCO3 CC(=O)NC1CCN(C(=O)C[C@@H1]2C[C@@H1](O)CN2C(=O)[C@H1](O)C(F)(F)F)CC1 CCN(CCNC(=O)C1=CC2=C(N=N1)CCC2)C(=O)C3=CC(N)=CC=C3[N+1](=O)[O-1] CC[C@]1(C)C=C(C(=O)N2CC[C@@H1](O)[C@H1](NC(=O)C3=CC=CC(NC(C)=O)=N3)C2)C1 CC=1N=C(C(C)C)OC=1C(=O)N(C)CCN(C)C(=O)CN(C)C2CC2 CC1=COC=C1C(=O)N2CC(NC(=O)C3=NOCC34CCOCC4)C2 CCC(C)(C)C(=O)N1C[C@H1]2CC[C@H1]1C[C@H1]2NC(=O)CC3CCCC3 CC1=CC=C(CO)C(NC(=O)CC2=CCN(C(=O)CCC=3C=CN(C)C=3)CC2)=C1 C[C@@H1](CN(C)C)C(=O)N[C@H1]1CCC[C@@H1](NC(=O)C2=C[NH1]N=C2C(F)(F)F)C1 COC[C@@H1](NC(=O)NCC=1C=NN(C(C)(C)C)C=1)C2=CC=CC(Cl)=C2 CC1=C(C)C[C@H1](C(=O)NC[C@H1](C)NC(=O)C2=C[C@]3(CCOC3)C2)CC1 CSC1=CC=C(C2=CN(CC(F)(F)CN3CCOCC3)N=N2)C=C1 CCC1CC(NC(=O)[C@@H1]2C=C[C@@H1](NC(=O)C=3C=CC4=NN=CN4C=3)C2)C1 C=CCC(C)(C)C(=O)N[C@@H1]1CN(C(=O)CN2CCCOC2=O)C3(CCC3)C1 CC1(C)C(CC(=O)N2CC3(CCC(NC(=O)[C@H1]4CC(=O)NC4(C)C)CC3)C2)C1 CCC(C)(C)NC(=O)[C@H1]([C@@H1](C)C1CCCC1)N2CCC[C@H1]2CCO OC[C@H1]1CN(CC2=CC(Cl)=CC=C2[N+1](=O)[O-1])CC13CC3 CSC=CC(=O)NC[C@H1]1[C@@H1](CNC(=O)C=C(C)Cl)C1(F)F CC(C)(C(=O)N[C@@H1]1COC2(C1)CN(C(=O)C=3[NH1]N=NC=3C4CC4)CC2)C(F)(F)F CCC(CC)N(C)CCC(=O)N[C@H1]1CCN(C(=O)C=CSC)[C@H1](C2CC2)C1 CN(CCOCCN=C1[NH1]C(Cl)=NC(C2CC2)=C1F)C(=O)[C@H1]3CCC[C@H1](C(N)=O)C3 C#CC(C)(C)C(=O)N1CC[C@H1]2CN(C(=O)C3=CC(C(=O)OCC)=C(C)[NH1]3)C[C@H1]2C1 CO[C@H1]1CCC[C@@H1](CC(=O)OCCOCCOCCF)C1 CC(=O)N1CCC(CC(=O)N2CCN(C(=O)CC3=CC=CS3)[C@H1](C)[C@H1]2C)CC1 CC1=NSC(C(=O)NC[C@]2(CNC(=O)C[C@@H1](C)C(C)(C)C)CC23CCC3)=C1N C[C@@H1](O)C1=CN(C2=CC=CC=C2C(=O)NCC3(CO)CC4(CC(F)(F)C4)C3)N=N1 CCC1=NC=C(C(=O)N(C)CCCN(C)C(=O)CC(C)(C)SC)[NH1]1 CCC1=CC(Cl)=CC=C1C(=O)N2CCC(CNC(=O)C3=CC(Cl)=C(Cl)S3)CC2 C[C@H1]1CC[C@H1](C(=O)NCC23CN(C(=O)CCC4CCC4)C(CCO)(C2)C3)S1 C[C@H1](CNC(=O)[C@@H1]1CCCC12CC2)CN(C)C(=O)C=CC3=CC=CN=C3 CC1=CC=C(CCNC(=O)C[C@@H1]2CC3(CC3)CN2C(=O)[C@H1](O)C4CCC4)C=N1 C[C@@H1]1C[C@H1](C(=O)N[C@]2(CNC(=O)CNC(=O)C(F)(F)F)CCCC[C@H1]2)[C@@H1](C)O1 CCC(C)=C(C)C(=O)N[C@H1](C)C1CCN(C(=O)C2(O)CCCCC2)CC1 CC1(C)CC2=CC=CC=C2[C@H1]1NC(=O)N3CCOC[C@@H1](C(C)(C)C)C3 COCCNC(=O)C(=O)N[C@H1]1C[C@](C)(NC(=O)[C@H1]2CCN2CC3=CC=CC=C3)C1 CC1=C(C(=O)N2CCC(CCNC(=O)CCN3CCOCC3)CC2)C=CN1C CS[C@H1](C)[C@@H1](O)C(=O)NC1(CCNC(=O)CCC2=CC=CN=C2)CC1 CC1=CC=C(F)C=C1NC(=O)N2CC[C@@]2(C)C(=O)NCCN3CCN(C)CC3 CC(C)=C(C)C(=O)N1CCCC[C@@H1]1CNC(=O)CCNC(=O)C=C2CC[C@@H1](C)C2 CC1=CON=C1CC(=O)N[C@H1]2CN(C(=O)CN3C=NN=C3O)CC[C@H1]2CO CCC=1C=CSC=1C(=O)N2CCC[C@H1](CNC(=O)C=3C=CC4=N[NH1]C=C4C=3)C2 O=C(C[C@@H1]1CC2=CC=CC=C2CN1C(=O)CC[C@@H1]3CCOC3)NCC[C@@H1]4C=CCC4 O=C(N[C@H1]1CCO[C@@]2(CCSC2)C1)C3CCC4=CC=CC=C4CC3 O=C(C[C@H1]1CNCCOC1)NCCCCCC2=CC=CS2 O=C(NC1CN(C(=O)C=2C=CC3=NC=C(Br)N3C=2)C1)C4=CC=CN5N=CC=C45 CC(C)C1=NN=C(C(=O)N2CC[C@H1](CCNC(=O)[C@@H1]3CCCS3)C2)S1 C[C@H1](CCCO)CN[C@]1(C2=NN=NN2C3CCCC3)CCSC1 CC1=NC(C(=O)N[C@@H1]2CC[C@@H1](C)N(C(=O)C3=C[NH1]C(C(F)(F)F)=C3)C2)=CS1 C=CC1=CC=C(C(=O)N[C@@H1]2CCC[C@H1]2CNC(=O)C34CC(C(=O)OC)(C3)C4)C=C1 C[C@H1]1CC2(CCN(C3=NN=NN3C[C@@H1]4CC45CC5)CC2)CO1 CCN1C=C(C(=O)NC[C@@H1]2C[C@H1]3CC[C@H1]2N3C(=O)C4=C(C)SC(C)=C4C#N)N=N1 C[C@H1](NC(=O)CC1CSC1)[C@@H1](C)NC(=O)C2CCC(CO)CC2 CC1=NC(O)=CC(C(=O)N[C@H1]2CCCCN(C(=O)C[C@@]3(C)CCS(=O)(=O)N3)C2)=N1 CN(C(=O)[C@H1]1CNC(=O)C1)C2CC(NC(=O)C[C@H1]3COC4CC3C4)C2 COC1=CC=C(C=CC(=O)N2C[C@H1](NC(=O)C3=CCCCO3)C[C@@H1]2C)C=C1O CCC[C@H1](CC(C)C)C(=O)N[C@H1]1C[C@H1]2CC[C@@H1]([C@@H1]1F)N2C(=O)C3=CSC(C)=C3N COC1=CC(C(=O)N[C@@H1]2CCCCC[C@H1]2NC(=O)C3=NC=CC(N)=C3Cl)=NC=N1 CC(=O)C1=CC=CC(C(=O)NCC2(O)CN(C(=O)C(C)(C)[C@@H1]3CCCN(C)C3)C2)=C1 CO[C@@H1](CSC)CNC1=CC(N(C)CC(=O)NC2CC2)=NC=N1 CC1=CC(C(=O)NC[C@H1]2C[C@H1]2C(F)(F)F)=NN1C3=CC=C(Cl)C=C3 CCCCCCN1C=C([C@@H1]2C[C@H1]2C(=O)NCCC3(COC)CCC3)N=N1 C=CCCCCCC(=O)N1CCN(CC2(NC(=O)CC=3N=COC=3C)CC2)CC1 CC1=CC=C(SCC(=O)N2C[C@@H1]3C[C@H1]2C[C@H1]3CNC(=O)[C@@H1](F)C4CCC4)C=C1C CC1=NC(C2=CC=CC(NC(=O)N[C@@H1]3CCS[C@@H1](C4=CC=CN=C4)C3)=C2)=CS1 CC1=CC(C(=O)N2CC[C@H1](CC(=O)NC3=CC(O)=NC(Cl)=N3)C2)=CC=C1I CC1=CC=C(C=CC(=O)N2CCC[C@H1](CCNC(=O)C3=C(C)N=CN=C3C)C2)O1 CC[C@@]1(C(=O)N2CC(C3=NC(=O)O[NH1]3)C2)CCCN(C(=O)CC4=CCOCC4)C1 CCOCCC(=O)N[C@H1]1CN(C(=O)C2=C(C)C=CN=C2C)C[C@@H1]1C3CC3 C=C(Br)CC(=O)N(C)C[C@@H1](C)NC(=O)[C@@]1(C2=CC=CC=C2)C[C@H1]1C C=C=C(C)CC(=O)NCCOC(C)(C)CNC(=O)[C@H1](C)N1C=CN=C1C COC(=O)N[C@H1](C)CNC(=O)[C@@H1](C)[C@@H1]1CCN(C(=O)CCC(=O)C2CC2)C1 CCC1=NC=C(C(=O)N2C[C@H1](CNC(=O)CC3=CN=NS3)CC[C@@H1]2C)C(C)=N1 CCC1=NC(O)=C(C(=O)N(C)[C@H1]2[C@@H1]3CN(C(=O)[C@@H1]4CCCOC4)C[C@@H1]32)C=C1C CC[C@@H1](C(=O)N[C@@H1](CO)CNC(=O)C1=CN=C2C(C=NN2C)=C1OC)N(C)C CCOCCCCNC(=O)C[C@@H1](NC(=O)C1=CC=C2C=C[NH1]C2=C1)C3CC3 O=C(CNC(=O)C1=CC=CS1)NCC2=CSC(CNC(=O)[C@@H1]3CC34CC4)=N2 CC1=NC(CN[C@H1]2CC[C@H1](C(=O)NC3=CC=C(CO)C=C3)C2)=CC=C1Br CO[C@H1](CO)C(=O)N1C[C@@H1]2C[C@H1](C1)N2C(=O)[C@H1](C)CC3=CC=CC=N3 C[C@H1](C(=O)N(C)CC[C@H1]1CCCCN1C(=O)C2=C[NH1]C=C(F)C2=O)N3C=CC=C3 COCCCNC(=O)CN(C)[C@@H1](C(=O)NCC1=CC=CC(Br)=C1)C=2C=NN(C)C=2 CSCC[C@@H1](O)CC(=O)NCCCCCN(C)C(=O)[C@@H1](C)C1CC1 CC1=CC=CC(C(=O)NCC[C@@]2(C)CCN(C(=O)CC(F)F)C2)=C1O CCC1=CC=C([C@H1]2C[C@@H1](C)CCN2C(=O)C3=CC4=C(O3)CCC(C)(C)C4=O)O1 FC1(F)C[C@]12CC[C@H1](NCCOCCN3C=CN=C3)C2 CC=1C=C(CC(=O)NCC2CC(O)(CNC(=O)C=3SC(C)=NC=3C)C2)N(C)N=1 CCNC(=O)[C@@H1](C1=CC=C(Br)C=C1F)N(C)CCCC(=O)OC(C)(C)C CC(C)N1C=CC(C(=O)NC2(C(=O)NCCC3=NN=CN3C)CSC2)=N1 CCCC=C(CC)C(=O)NC[C@@H1]1CCCN1C(=O)COC2=CC=CC=C2 CC[C@H1](CC(=O)N[C@@H1]1CN(C(=O)[C@@H1]2C3=C[NH1]N=C3CC[C@@H1]2C)CC[C@H1]1)C(C)C C[C@@H1]1CCN(C(=O)NC[C@@H1]2CC3(CCCC3)CO2)CCC1(F)F CC1=CC(O)=CC=C1NC(=O)[C@]2(C)CN(C(=O)C3=CC=NC(C)=C3N)C(C)(C)C2 O=C1O[C@H1]2C[C@@H1](C(=O)N3CCO[C@@H1](CCNC(=O)C4=NC(Cl)=CS4)C3)C[C@H1]2O1 CC(C)C1=C[NH1]N=C1C(=O)NC[C@H1](NC(=O)C[C@@H1]2CCCC(=O)N2)C3CCC3 CSC1=CC=CC(N(C)C[C@@H1](O)CN(C)C(=O)C[C@@H1]2CCCNC(=O)C2)=C1[N+1](=O)[O-1] CC[C@](C)(CCC(C)C)C(=O)N1CCC[C@@H1]1CN(C)C(=O)C2CN(C)C2 C[C@@]1(C(=O)N[C@@H1]2CC[C@H1]2NC(=O)C3=CC=C(S(N)(=O)=O)O3)OCCCS1 CSC1=CC=CC(N2N=C(CN3N=CC=N3)N=C2C4=CN=C(Cl)C(F)=C4)=C1 O=C(C1=C(O)C=CC=C1O)N2CCN(C(=O)C=3N=NSC=3C4CC4)C[C@H1](O)C2 O=C([C@@H1]1OC[C@@H1]2CCC[C@@H1]21)N(C[C@H1]3CCCN3C(=O)CC4CS(=O)(=O)C4)C5CC5 CC1=CC(N)=C(C(=O)N2CC(CNC(=O)CCN3C(C)=CSC3=O)C2)C(F)=C1 CC1=CC=C(CN2N=NN=C2N3CCC[C@H1]([C@H1](C)NC(=O)[C@@H1]4CCC[C@@H1]4C)C3)S1 COC1=CN=NC(C(=O)N[C@@H1]2COCCN(C(=O)C3=CC=C4C(=C3)OCC4)C2)=C1 C#CC1=CC=C(CC(=O)NCCCC(=O)N2CC[C@@H1](CC(C)C)C2)C=C1 COC1=CC=C(I)C(C(=O)N2CCNC(=O)[C@@H1]2CC(=O)O)=C1 CC1CC2(C1)CC(C(=O)N3CCOC[C@@H1]3CC(=O)NCC4=CC=CC(O)=C4)C2 CCOCCCC(=O)NC[C@@]12CC[C@@H1](CN(C(=O)[C@H1]3COCCN3C)C1)C2 CCCC1=CC(C(=O)N[C@H1](C)C[C@@H1](C)NC(=O)C2=CC(C)=C[NH1]2)=N[NH1]1 CC(C)C1=NC=C(CN(C)C(=O)[C@@H1](F)[C@@H1](C)CNC(=O)C2=CC=CC=C2)C=N1 CC=1[NH1]C2=NC=CC=C2C=1C(=O)N3CC[C@](CO)(NC(=O)C=CC(=O)N(C)C)C3 C#CC(C)(C)C(=O)N1CCCC[C@H1](C2CN(C(=O)[C@H1](C)SCC)C2)C1 CCN1CC[C@H1]1C(=O)NC[C@H1]2CCN(C3=NC=NC(Cl)=C3C(C)=O)C2 CCN(C(=O)CC=1C=NN(C(C)C)C=1)[C@H1]2CCN(C(=O)C3=N[NH1]C4=C3COC4)C2 C=C[C@@H1]1CC[C@H1]1C(=O)N2CCC3(CCCN3C(=O)[C@@H1](C)C4=CC=CO4)CC2 CCOC1=CC(C(=O)N2CC[C@H1]3CN(C(=O)C=4OC=C5C=4CCC5)C[C@H1]32)=CC=N1 CCC1=CC=C(C(=O)N2CCC[C@H1]([C@H1](C)NC(=O)C=3SC(F)=CC=3C)C2)C=C1N O=C(C[C@H1]1CCCC12CC2)NCC[C@]3(O)CCN(C(=O)C4=NC=NC(O)=C4Cl)C3 CC1=CC(C(=O)N2CC[C@H1]3NC(=O)CC[C@H1]3C2)=NN1C4=CC=CC=C4 CC1=CC=C(C(=O)N[C@@H1]2CN(C(=O)[C@@H1](C)C3CCCC3)CC4=NC=CN4C2)N=N1 CN(C)[C@@H1](CO)C(=O)N[C@@H1]1CCN(C(=O)/C=C/C2=CC=C(Cl)C=C2F)C1(C)C CNC1=CN=C(Cl)C=C1C(=O)NC[C@@H1]2C[C@@H1](NC(=O)C[C@@H1]3CC4(CCCC4)CO3)C2 CC[C@H1](C)CC(=O)N1CC[C@]2(CNC(=O)C3=CC=CN=N3)CCCC[C@H1]12 CON=CC(=O)N[C@@H1](CC1CC1)C(=O)N[C@@H1]2CCOCC2(C)C CO[C@@H1]1CCN(C(=O)CCN(CCO)C(=O)C[C@@H1]2CCCSC2)C13CCC3 CCCC1(C(=O)N[C@@H1](CO)CNC(=O)C=2C=C(C3=CC=C(C)C=C3C)ON=2)CC1 CC=CC(=O)N1C[C@H1]2CCN(C(=O)C3=CC(F)=N[NH1]3)C[C@H1]2C1 CN(CCCCCNC(=O)[C@H1]1C[C@@H1]1F)C(=O)[C@H1]2C[C@@H1]2C3=CC=CC=N3 C[C@H1](C(=O)N[C@H1](C)C1=CC=CC=C1)N2CC[C@H1](NC(=O)C(C3CC3)C4CC4)C2 CN(C)C[C@H1](CNC(=O)N[C@@]1(CO)CCS(=O)(=O)C1)C2=CC=C(Cl)C=C2 C[C@H1](CC(=O)NC(C)(C)C/C=C/C(=O)N(C)C[C@@H1]1CCCCO1)CN(C)C COC1=CC=CC(C)=C1C(=O)N(C2=C(OC)C=CC=C2C(=O)OO)C3CC3 COC1=NC=C(C(=O)N[C@@H1]2C=C[C@H1](CC(=O)N3CCOC[C@@](C)(O)C3)C2)S1 CC1=CC(=N[C@H1](CCO)C2=CC=CC=C2C)[NH1]N=C1S(N)(=O)=O O=C1CCC(C(=O)N2[C@H1]3CC[C@@H1](C3)[C@@H1]2C(=O)N[C@@H1]4C[C@H1]4C5=CC=C(Br)C=C5)=NN1 CCN1N=NN=C1NC(=O)[C@@H1]2[C@H1]3CN(CC4=CC=C(N5C=CC=N5)C(Cl)=C4)C[C@H1]32 CC[C@H1]1C[C@@H1]1CC(=O)N2C[C@H1]3C[C@@H1](NC(=O)C=CC4=CN=C(C)S4)C[C@H1]2C3 O=C(CC1=C[NH1]N=C1O)NC/C=C/CNC(=O)C2=CC=C(N3CC=CC3)C=C2 C[C@@H1]1[C@@H1](C)N(C(=O)CN2C(=O)NC(C)(C)C2=O)CCN1C(=O)CCC#N COC1=CN=CC(CNC(=O)[C@H1]CCC(C)(C)N(C(=O)[C@@H1](F)CC(C)(C)C)C)=C1 CC1=CN(C)N=C1C(=O)N2C[C@H1](C(=O)NC(C)(C)CCN(C)C)[C@@H1](C(C)C)C2 CCCN1N=NN=C1[C@@H1](NC[C@@H1](C)C(C)(C)C)C2=CN=C3C(=C2)CCC3 C[C@@H1](CN1C=CC=N1)C(=O)N[C@H1]2C[C@@](C)(NC(=O)CCN3CCCC3)C2 C[C@@H1]1SCCC[C@@H1]1C(=O)N2CC(C)(OCC(=O)N3CCOCC[C@H1]3C4CC4)C2 CC1=NC(C(C)(C)NC(=O)C(C#N)C(C)(C)C)=NO1 COC1=CC(C(=O)NCC2CC(NC(=O)C3=C(C)C=CN3C)C2)=CC=N1 COC1=CN=CC=C1C2=CC=C(C3(NC(=O)[C@@H1]4C=CC(=O)N=N4)CC3)C=C2 COCCOCCC(=O)N[C@H1](CO)C(=O)N1CCCC[C@@H1]1C CCC=1SC(=N)[NH1]C=1C(=O)N2CC[C@H1](NC(=O)CN3CC(=O)N(C)C3=O)[C@@H1](C)C2 CC1=NC(N2CC=C[C@@H1](NC(=O)C=3N=C(Cl)SC=3C)C2)=C4SC=C(C)C4=N1 CC(=CC(=O)N1CC(CNC(=O)C2=CN=CC(C)=C2C)C1)C3=CC=CC=C3 COCC1=CC=CC=C1N2C=C([C@H1]3CN(C(=O)C(C)(C)CN(C)C)CCO3)N=N2 COC(C)(C)[C@H1](C)NC(=O)[C@H1]1CC[C@H1](C)CN1C(=O)C2=CC=NC(C)=C2 O=C(C[C@H1]1CCOC1)NC[C@]2(O)CCCN(C(=O)C3=C[NH1]C4=CC(F)=CC=C34)C2 CCCN(C(=O)C=1N=NSC=1C)C2CCN(C(=O)[C@@H1]3CCCNC3=O)CC2 CCC[C@H1]1CN(C(=O)CO[C@@H1]2CCCOC2)C[C@@H1]1C(=O)N(C)C[C@H1](C)N3CCCC3 CC[C@H1](O)C(=O)N1C[C@@H1]2CN(C(=O)C=3SN=C(Cl)C=3Cl)C[C@H1]21 COC(=O)CS(=O)(=O)CC(=O)N[C@@H1](C)C1=CC=C(C)O1 CC/C(C)=C/C(=O)N[C@H1]1C[C@H1]2CC[C@H1]1N(C(=O)[C@@H1](OC)C3=CC=CC=C3O)C2 CN(C(=O)CC[C@@H1]1CC1(Cl)Cl)C2CC(NC(=O)CC=3C=C[NH1]N=3)C2 C[C@@H1](NC(N)=O)C(=O)NCC1C[C@@H1]2CCC[C@H1](C1)N2C(=O)C=CC3=COC=N3 CCCC(=O)N1CSC[C@H1]1C(=O)N(C)C[C@H1](O)CN(C)C(=O)C=2SC=CC=2OC CC1=CC(C(=O)NCC2(NC(=O)[C@H1]3CC[C@H1]3F)CCCC2)=CC(C)=C1OC(F)F CN1C=C(Cl)C(C(=O)N2CC[C@](O)(CNC(=O)[C@@H1]3CCCN3C(=O)C4CC4)C2)=N1 C[C@H1](C(=O)NC[C@H1](NC(=O)C1=CC(F)=C2[NH1]N=NC2=C1)C(C)(C)C)C3CCCC3 CC1CCC(C(=O)N2C[C@H1](C)CC[C@H1]2C(=O)N3CC=C[C@@H1]3CF)CC1 CN(C)[C@@H1](C(=O)N[C@@H1]1C[C@@H1]2C[C@H1](NC(=O)CN3C=NN=N3)[C@H1]1C2)C4CC4 CC1=CC=C(Cl)C(CN=C2N=C3SC=CC3=C(N4CCC[C@]5(C=CCO5)C4)[NH1]2)=N1 C=CCO[C@@H1](C)C(=O)N(C)[C@@H1]1CCCCN(C(=O)COC(C)=O)C1 CCCCC[C@@H1](NC(=O)N1CCC[C@@](O)(C2=CN=N[NH1]2)C1)C3CC3 CNS(=O)(=O)C1=CC=C(F)C(C(=O)N(C)[C@@H1]2CN(C(=O)C(C)(F)F)C[C@H1]2F)=C1F CCN1C=CC(=NC(=O)[C@]23CO[C@H1](C2)[C@H1](NC(=O)[C@@H1]4CCC[C@H1](C)CC4)C3)[NH1]1 CCC[C@@H1]1CN(C(=O)[C@H1](C)CS(C)(=O)=O)CCN1C(=O)CS(C)(=O)=O CSCC[C@H1](C(=O)NC1CC(C)(NC(=O)CC2=CC=C(C)C(O)=C2)C1)N(C)C CC1(C)C[C@@H1](NC(=O)CCC=2C=NOC=2)CN1C(=O)C3=CC=C4C=NC=CC4=N3 CC1=N[NH1]C=C1NC(=O)[C@H1]2CN(C(=O)CN3C(=O)CSC3=S)CC(F)(F)C2 COC1=CC=CC=C1C(C)=CC(=O)NC[C@@H1]2C[C@H1]2CNC(=O)[C@H1]3C[C@H1]3C CCC1(C(=O)NCC2[C@@H1]3CN(C(=O)CN4C=CC=N4)C[C@@H1]23)CCC(F)(F)CC1 C#CC1(N(C)C(=O)[C@@H1]2[C@H1]3CN(C(=O)CC4=CC=NN4C)C[C@H1]32)CC1 CCC(C)(CC)CNC(=O)[C@@H1]1COCCN(C(=O)[C@H1]2C[C@H1]3O[C@@H1]2[C@@H1]4C[C@H1]34)C1 COC1=CC(Br)=C(CN(C)C(=O)C2=NC=CC=C2N)C=C1OC O=C1CC[C@@H1](C(=O)NC[C@H1]2CCN(C(=O)C3=NN=C4C=CC=CC4=N3)C25CC5)C1 CO[C@](C)(CNC(=O)C1=CC=CN=N1)CNC(=O)C2=CC(C)=CC=C2Cl CC[C@H1](CC(=O)N1CCC[C@](C)(CNC(=O)C2=CC(F)=C3N=CC=CC3=C2)C1)OC CCC1=NN(C)C(C(=O)NC[C@@H1]2[C@H1](CN3C=C([C@H1](C)O)N=N3)C2(F)F)=C1Br C#CC=1C=NN(CC(=O)N2[C@H1](CNC(=O)[C@@H1](F)C[C@@H1]3CCOC3)C[C@@H1]4C[C@@H1]42)C=1 C=CC[C@@H1](C)C(=O)N(C)C[C@@H1](CC)NC(=O)C1=CC=C([N+1](=O)[O-1])C=C1O CCC1=CN=C(Cl)N=C1N2[C@H1]3CC[C@@H1]2C[C@@H1](CNC(=O)C(F)(F)C(F)(F)F)C3 C#CC=1C=NN(C)C=1C(=O)N2CCN(C(=O)C3=CC=C(Cl)S3)[C@@H1](C4CCCC4)C2 CC=1SC(O)=NC=1C(=O)N[C@@](C)(CNC(=O)[C@]2(CF)CC2(F)F)C3CCC3 CN(C[C@@H1]1CCCN1C(=O)CCC2=CSC=N2)C(=O)C3=CN4C=CC=NC4=N3 CC(=CC(=O)N[C@@H1]1CN(C(=O)C2CN(C)C2)C[C@H1]1C3=CC=NN3C4)CC=CS4 C[C@]1(NC(=O)C2=CC=3OC=CC=3[NH1]2)CCCN(C(=O)COCC4=CC=CC=N4)C1 O=S(=O)(NC1=CC=C2C(=C1)C(=O)NC2)C3=CC=C(F)C=C3C(F)(F)C(F)(F)F O=C(NC[C@H1]1CCN(C(=O)C[C@H1](C(F)F)N2C=CN=C2)C1)C3=NSN=C3O CCN1C=NC(C(=O)NC[C@@]2(C)CC[C@@H1](NC(=O)C=3SC=CC=3C(C)C)C2)=N1 CC(C)(CNC(=O)C1=CC=C(F)C(Cl)=C1N)NC(=O)C[C@@H1]2CCC[C@@H1](O)C2 CCOC1=CC=CN=C1C(=O)NC[C@@H1]2CN(C(=O)C=3N=C(O)[NH1]C(=O)N=3)[C@H1]4C[C@@H1]42 CO[C@@](C)(CC1CCC1)C(=O)N[C@@H1]2CN(C(=O)C3=C(C)C=CC=C3Cl)C[C@@H1]2F C[C@@H1]1CC[C@H1](NC(=O)C2=CC=C(O)N=C2Cl)CN1C(=O)CC[C@@H1]3CCOC3 CC1=NC(COC(=O)C2=CN=C3C=CC=CC3=N2)=N[NH1]1 C=CCC(C)(C)CC(=O)N(C)[C@H1](C)CCNC(=O)CN(C)C1=CC=NC(Cl)=N1 CCC[C@H1](C)CC(=O)NCC[C@@H1]1CN(C(=O)C2=C(C)C=C(Cl)C=C2C)CCO1 CC1=NC(C(=O)N[C@H1](C(=O)NCCCC2=CC=CN=C2)[C@@H1](C)O)=C(C)O1 O=C(C=CCF)N1C[C@H1]2C[C@@H1](NC(=O)C=3C=C(C4CC4)ON=3)CC[C@H1]2C1 CN(C)CC(C)(C)C(=O)NCC1=CN=CC(C(=O)NC[C@H1]2COC[C@@H1]2N(C)C)=C1 C[C@@H1]1CN(C2=CC(S(C)(=O)=O)=NC=N2)CC[C@@H1]1CNC(=O)[C@@H1]3C[C@@H1]3F C[C@@H1](C(=O)N(C)C1CN(C(=O)CC2CC(C(F)F)C2)C1)C(F)F CC1=N[NH1]C=C1CCNC(=O)CC[C@@H1]2CCCCN(C(=O)[C@]3(C)CCCCO3)C2 CCCN1N=NN=C1[C@@H1](C[C@H1](C)SC)NC2=CC=CC(C(=O)NC)=C2 O=C1CN(CC(=O)NC23CCC(CC2)N(C(=O)C4=CC=CC(Cl)=C4)C3)CCN1 CCC1=CN=C(C(=O)N2C[C@@H1](C)C(NC(=O)C3=CC(C)=NC=C3C)[C@H1](C)C2)N=C1 CC1=CN=C(C)C(C(=O)N2CC[C@]3(C[C@@H1]3C(=O)N4CCCC[C@@](C)(F)C4)C2)=N1 C[C@H1](C(=O)N[C@H1]1CC[C@H1]2C[C@H1]1CN2C3=NC=NC4=CC=CN=C34)[C@@H1]5CCOC5 COCC(=O)NCCC(=O)N1CCC(CNC2=CC=NC3=NC(C)=NN23)C1 CN1N=NN=C1SCC(=O)N[C@@H1]2CCC[C@@H1]2CNC(=O)C=3C=C4C=CC=NN4N=3 N=C1N=CN(CC(=O)N2C[C@H1]3C[C@H1]2C[C@H1]3NC(=O)C4=CC(C(N)=O)=CO4)[NH1]1 C[C@H1](CC(=O)N1CCCC[C@H1]1CC(N)=O)NC(=O)C2=CC=C3C(=C2)CCC3 C#C[C@H1](CNC(=O)[C@@H1]1[C@H1](CC)CCCN1C(=O)[C@H1](C)N2C=NC=N2)CC(C)(C)C O=C(NCC[C@@H1]1CN(C(=O)C2=CC(Br)=CS2)CCCO1)C3=CSC(Cl)=N3 CC=1N=NSC=1CN=C2C=CN=C(N[C@H1](C)CN3CCCC3)[NH1]2 CC(C)(C#N)CCCC(=O)N1[C@H1]2CC[C@H1]1CN(C(=O)C3=CC=NN3CCF)CC2 CCOC(=O)[C@H1]1C[C@](F)(C(=O)N2C[C@@H1](NC(=O)[C@@H1](C)SC(C)C)CC2(C)C)C1 CNC=1SN=C(C)C=1C(=O)N2CCN(C)[C@@H1](CNC(=O)C#CC(C)(C)C)C2 CCN(C[C@H1]1CCCCN1C(=O)[C@@H1](O)CN2C=NC=N2)C(=O)C3=CC=C(Cl)O3 CN1C=C(Br)C(CNC(=NCCCCl)NC[C@H1]2CC3(CCCC3)CO2)=N1 C[C@@H1](C1=CC=CN=C1)N(C(=O)NCC2=CC=CC=C2N3CCCCC3=O)C4CC4 CC(=O)N[C@@H1](C)C(=O)NC[C@H1](CO)NC(=O)C1=CC=C2C(=N1)OCCO2 CNN=NC(CNC(=O)[C@H1]([C@H1]1CCCSC1)N2CCC[C@@H1](C(F)(F)C(F)(F)F)C2)=N C/C=C/C[C@@H1](C)C(=O)NCC1(C(=O)NC[C@]2(C)CCCOC2)CCCCC1 CSC[C@@H1]1CCN([C@H1](C(=O)NC2CCC2)C3=CNC(=O)C=C3)C1 CC1CN(CC(=O)N[C@H1](CCNC(=O)C=2OC=CC=2C3CC3)C(C)C)C1 CC(C)(CNC(=O)[C@H1](O)CCC(F)(F)F)NC(=O)C[C@H1](O)C(C)(C)C C[C@H1](CC(N)=O)NC(=O)CCCSCC1=CC=C(Br)C=C1 CS[C@H1](C(=O)N1CCC[C@@H1](NC(=O)C=C2C[C@@H1]3CC[C@H1](C2)N3C)C1)C4CC4 C[C@H1](NC(=O)C=1[NH1]C(=N)C=CC=1Br)C(C)(C)CO C[C@@H1]1CC[C@@H1](NC(=O)C[C@H1]2CCC3=CC=CC=C3N2)CC4=CC=CC=C41 C[C@@H1](CNC(=O)CN(C(=O)C1=COC2=CC=CC=C12)C3CC3)C=4C=NN(C)C=4 CC[C@H1](NC(N)=O)C(=O)N1CCN(C(=O)CC2(CSC)CC2)[C@H1](CO)C1 C#C[C@H1](C)C1CCN(C(=O)C2=CC[C@H1](NC(=O)[C@](C)(C=C)CC)C2)CC1 COCC1(N(C)C(=O)C[C@]23CC[C@@H1]2CN(C(=O)C(C)(C)CCF)C3)CC1 CN1N=C(C(C)(C)C)C=C1NC(=O)CCN2C(C3CC3)=NC4=CC=CC=C42 O=C(C[C@H1]1CN(C(=O)C2=CC=CC=[N+1]2[O-1])CCO1)NC[C@@H1]3[C@H1]4CCCO[C@@H1]34 CC1=CN2C=C(C(=O)N3C[C@H1]4[C@H1](NC(=O)CC5C[C@@H1]6C[C@H1]6C5)[C@H1]4C3)N=C2S1 CC1=CC=C(C2=CSC(=O)N2CC(=O)N(C)[C@@H1](CNC(=O)CCC#N)C3CC3)S1 O=C([C@@H1]1C[C@@H1]2C=C[C@H1]1CCC2)N3CCN(C(=O)C4=CC=CO4)[C@@H1](C5CC5)C3 O=C(NCCCCN=C1C=C(C2CC2)N=C(Cl)[NH1]1)C3=CC=C(CC4CC4)C=C3 C[C@H1]1C[C@@H1](C(=O)NC2[C@H1]3CCC[C@H1]2CC3)CN(C(=O)CC4=CN=NS4)C1 COC1(CC(=O)NC2([C@@H1]3CCCN3C(=O)[C@@H1]4CCCS4)CC2)CCC1 CC=1[NH1]N=C(C2=CN(CC(=O)NCCCNS(N)(=O)=O)N=N2)C=1C CC[C@H1](CN(C)C(=O)C[C@H1]1C[C@H1]1CNC(=O)C2=C[C@H1]3CC[C@@H1](C2)C3)OC O=C(COC1=CC=CN=C1)NC[C@@H1]2OCC[C@@H1]2C(=O)NCCCC3=CC=NN3C CC=CC(=O)NC[C@@](C)(CO)NC(=O)C1=CC(F)=C(Cl)C=C1F COC[C@@]1C2C[C@@](C(=O)NC3=CC=CC(Br)=C3C#N)(CO2)C1 CC1=NN(C)C=C1CC(=O)N(C)CCN(C)C(=O)C(=O)N=C2C=C(C)O[NH1]2 C[C@@H1]1CCN(C(=O)CN2CCCS2(=O)=O)C[C@@H1]1NC(=O)C3=CN(C(C)(C)C)N=N3 CC1=CC(CCC(=O)N2CCC(O)(CCNC(=O)[C@@H1]3CN(C)C(=O)N3)CC2)=N[NH1]1 CC=1C=CSC=1[C@@H1]2C[C@H1]2C(=O)N3CCC(CN(C)C(=O)CN4N=CC=C4C)CC3 CCOC=CC(=O)N1CC2(CCN(C(=O)[C@@H1](CN(C)C)C(C)C)CC2)C[C@@H1]1C C=C(CCNC(=O)C=1C=C(C)N(C2=CN=CC=N2)C=1C)CNC(=O)C3CCCC3 O=CNCC(=O)N1CCC2(CC1)C[C@@H1](NC(=O)[C@@H1](F)C3CCC3)CO2 N#CC1=CC=C(C(=O)N[C@H1]2CCCC[C@@H1]2C(=O)NCCCO)C=C1[N+1](=O)[O-1] CC1=CC=CN=C1CC(=O)N2CCOC[C@@H1](NC(=O)C3=CC=CC(C)=C3C)C2 O=C(C[C@H1]1CCC1(F)F)NCCOC2CN(C(=O)C3=CN=C4N(C3=O)CCS4)C2 CC1=NN(CCCl)C(C)=C1CNC(=O)[C@H1]2CC(=O)N([C@H1](C)C3=CC=C(Cl)C=C3)C2 C[C@H1](C(=O)N1CCC[C@@H1]1C(C)(C)C(=O)N[C@@H1]2CC[C@H1]3CC[C@H1]32)C(F)(F)F CCC=1N=COC=1C(=O)N2CC[C@@H1](NC(=O)COC3=CC=C(Br)C=C3)C2 CCNCC(=O)C1=CC=C(C2=CC=CC(C(C)=O)=C2F)CC(O)=N1 CCC[C@@H1]1C[C@H1]1C(=O)NC[C@@H1]2CCN2C(=O)C3=CN(C)C(C)=N3 O=C(CN1CCOCC1)N2C[C@H1](C(=O)N3CC4=CC=NC=C4C3)CC(F)(F)C2 O=C1NC[C@@H1](C(=O)NC[C@@H1]2C[C@]3(CCN(C(=O)CC=4SC(O)=NC=4O)C3)CO2)N1 CC1(C)OCC[C@@H1]1[C@@H1](C(=O)NCCCC2CC2)N3CCSCC[C@@H1]3C(=O)OC C=CCC1(NC(=O)C=2C=NOC=2)CN(C(=O)C[C@H1](C=C)CCC)C1 CC(=O)N1CCOC[C@@H1]1C(=O)N2CC(C)(NC(=O)C3=N[NH1]C4=CC(Cl)=CC=C34)C2 C[C@H1]1C[C@@H1](C(=O)NCCC2(O)CN(C(=O)C3=CC=NC(Cl)=C3F)C2)CCO1 C=CCC[C@H1](C(=O)N1C[C@@H1](O)[C@H1](CNC(=O)OC(C)(C)C)C1)C2=CC=CC=C2 C#C[C@@H1](CC(C)C)NC(=O)[C@@H1]1[C@H1]2CN(C(=O)CC3(C(=C)F)CCC3)C[C@H1]21 CC1=CC=C(F)C(O)=C1C(=O)NCC2(O)CCN(C(=O)CC3(C)CC3)CC2 CCCN(CCNC(=O)[C@@H1]1CCCC[C@@]12CC2(F)F)C(=O)C3=CC=C(C)C=C3 CCNC(=O)CC(=O)N1CCC[C@H1](C)[C@@H1]1CCNC(=O)[C@]2(COC)CC2(F)F CCC(=O)N[C@H1](CNC(=O)CC1=NOC2=CC=C(F)C=C12)[C@H1](C)C(C)C COC1=CC(C(=O)N2[C@H1](C)COC[C@H1]2C)=C(C3=CC=CC(F)=C3CO)C=N1 CCC[C@@H1](C(=O)OC)C(=O)N(C)CC(C)(C)CNC(=O)C1=NC(OC)=CC=C1Cl CC(C)(CNC(=O)C1=CN=C(N)C(O)=C1)NC(=O)[C@H1]2CCCC3(CC3)C2 CC1=C(C)C[C@](C)(NS(=O)(=O)C2=CC=C(NCCOC3=CC=CC=C3)N=C2)CC1 CCC=1ON=C(C)C=1C(=O)N[C@@H1]2C[C@@H1]2CNC(=O)COC[C@H1](C)C3=CC=CC=C3 C[C@H1](CNC(=O)[C@H1]1CC=CCC1)CN(C)C(=O)C2=CC=NC=3C=CSC2=3 N=C1[NH1]C=C(CNC2(C3=NN=NN3CCC4CC4)C[C@@H1]5CC[C@H1](C2)O5)S1 C#CCC[C@@H1](O)C(=O)NC[C@@H1](NC(=O)C(C)(C)C1CCC1)C2=CC=CC=C2CC C[C@H1](CNC(=O)[C@@H1]1CCCN(CC2=CC=CC=N2)C1)CN(C)C(=O)C3=CN=C[NH1]3 C=CCSCCNC(=O)C1=C(CNC(=O)[C@H1]2C[C@]2(C)C(F)F)C=NN1C C=CN1N=CC=C1C(=O)N2C[C@@H1]3C[C@@H1](NC(=O)C4(CO)CC4)[C@H1]2C3 COC[C@H1](C)C(=O)N1CCC[C@H1](C(=O)N2CCC[C@](O)(C(C)C)C2)CC1 CO[C@@H1](CNC(=O)CC1=CSC=N1)CNC(=O)C2=CN=CC3=CN=CC=C23 N[C@@H1]1CN(C(=O)C[C@@H1]2C[C@H1]3CCCC[C@@H1]3O2)CCC4=CC=CC=C41 CCC(=O)N[C@@H1](C)C(=O)N[C@H1](CO)CNC(=O)C1=CC=C(Br)C(O)=N1 CCC1(C#CC(=O)N[C@H1]2C[C@H1]3COC[C@@H1](C2)N3C(=O)CCCC4CCC4)COC1 COC1=CC=NC(OC)=C1C(=O)N2CC[C@H1](N(C)C(=O)C=C(Cl)Cl)[C@H1](C)C2 CC(C)(CCC#N)C(=O)N1CCC(C2CC(NC(=O)CNC(=O)C3CC3)C2)CC1 COC1(CC(=O)NCCNS(C)(=O)=O)CN(C(=O)C2(C#N)CC(=O)C2)C1 C=CCC[C@@H1](C)[C@@H1](C(=O)NC1=CC=C(Cl)C=C1F)N2CCN3CCOC[C@@H1]3C2 CC=CC(=O)NC[C@H1](CNC(=O)C[C@@H1]1OCC[C@@H1]1C)S(C)(=O)=O N#CC1=CC(C(=O)N2CCC[C@H1](NC(=O)C3=C(F)C=CC(F)=C3F)C2)=C[NH1]1 C=C(C)C[C@@H1](NC(=O)C=1N=COC=1CC)C(=O)NC[C@H1](O)CC(=O)OC CCOC1=CC=C(Cl)N=C1C(=O)N2CC3(CC[C@H1]3NC(=O)[C@@H1]4[C@H1]5CC[C@H1]54)C2 CC(C)C[C@H1](C)CC(=O)N[C@@H1]1CC12CCC(NC(=O)CCC=3C=C[NH1]N=3)CC2 CO[C@@H1](CC(C)C)C(=O)NC1CCCN(C(=O)[C@@H1](CC(C)C)NC(N)=O)CCC1 CO[C@H1](C(=O)N[C@@H1]1[C@H1]2CCN(C(=O)CC3=CC=C(C)S3)C[C@H1]21)C4CCCC4 COC1=NC=CC(C)=C1NC(=O)C[C@@H1](CNC(=O)[C@H1]2CCC2(OC)OC)OC CN1C=C(C=CC(=O)NC[C@@]2(F)CC[C@H1](NC(=O)[C@H1]3C(C)(C)C3(F)F)C2)C=N1 O=C(CN1CC[C@H1]2CC(=O)[C@@H1]1C2)NC3=CC=C4C(=C3)CC(=O)N4 COC1=CC=C(/C=C/C(=O)N[C@H1](CNC(=O)[C@@H1](C)N(C)C)C2CCCC2)C=C1 CC[C@H1](CCOC)C(=O)NC[C@H1]1CN(C(=O)C2=NOC=C2Cl)CCO1 C[C@@H1](NC(=O)C12COCC(C3=CC=C(F)C=C3)(C1)C2)C4COC4 C#C[C@@H1](CC)CNC(=O)N[C@@H1]1CCOC[C@H1]1OCC CC1=CC(C(=O)N[C@H1]2CCN(C(=O)CC3=CC=NS3)C[C@@H1]2O)=NN1C CC(=O)C1=CC=C(C(=O)NCC[C@@H1](C)NC(=O)[C@@H1]2C[C@@H1]3OC(=O)O[C@@H1]3C2)O1 O=C(NCC1=CC=NC=C1)[C@H1]2CN(CC3=NC=CS3)CCS2 O=C(N[C@H1]1CCCN(CC2=CC=CC=N2)C1)N3CC4(CC(C(F)(F)F)C4)C3 CC1=NC(=N[C@H1](C)[C@@H1]2CCCN(C(=O)[C@H1]3CCCO[C@H1]3C)C2)S[NH1]1 C=CCCCCCC(=O)N1CC[C@@H1]1CNC(=O)[C@H1](C)C2=CC=C([N+1](=O)[O-1])C=C2F C=CCN1N=NN=C1[C@@]2(NC3(C4=CC=C(F)C=C4C)CC3)CCC[C@H1](OC)CC2 CC[C@]1(C)CC[C@H1](C(=O)N2[C@@H1]3CC[C@@H1](C3)[C@H1]2CC(=O)N[C@@H1]4CCOC(C)(C)C4)O1 C[C@@H1]1C[C@@H1]1C(=O)N[C@](C)(CO)CNC(=O)C2=CC(C3=CC=CC=C3)=CS2 CN(C[C@H1]1CCCN1C(=O)C2=CC=3C=C(Cl)SC=3[NH1]2)C(=O)[C@H1]4CCNC(=O)C4 CCOC1=CC=C(OCCCC(=O)N2CC[C@@H1](N(C)C(=O)C=3C=C[NH1]N=3)C2)C=C1 CCN1C=CC(C(=O)N[C@H1](C)C[C@H1](C)NC(=O)CC[C@@H1]2CC2(F)F)=C1C CC1=CN=C[NH1]C1=NC[C@H1]2C[C@H1](NC(=O)CCC=3C=NN(C)C=3)CC[C@H1]2C CC=1SC=C(C(=O)NCCC2CC(C(=O)N[C@H1](C)C#N)C2)C=1C COC(=O)C1=CC=CN=C1N(CCCNC(=O)C(C)(C)N2C=NN=N2)C3CC3 CON=CC(=O)N1CCCC[C@@H1]1[C@H1](C)NC(=O)C=2N=NN3C=2CSCC3 C[C@@H1]1CN(C(=O)[C@]2(C)CCCN2C(=O)CN3[NH1]C=NC3=N)CC4=NN=CN41 CC1=CC=CC([C@@H1](N)CC(=O)NC2=CC=C(S(=O)(=O)NC3=CC=CC=C3)C=C2)=C1 CC(C)(CNC(=O)C=1C=CC(=O)N(C)N=1)NC(=O)C2=NC=NC3=C2C=NN3C COC[C@@H1](C)CC(=O)N1[C@H1]2CCC[C@H1]1CC(NC(=O)C3=N[NH1]C(C)=C3N)C2 CCC=1N=COC=1CNC=2[NH1]C(=NCCN3CCCCC3=O)N=C4N=CN(C)C=24 CC1=CC=C(N[C@@]2(C3=NN=NN3C4=CC=C(F)C=C4)CO[C@H1](C5CC5)C2)C=C1 COC[C@@H1](OC)C(=O)NC[C@H1](C1=CC=NC=C1)C2CC2 CC1=CC=CN=C1C2=CN(CC3(O)CCN(C(=O)[C@@H1]4CSCCS4)CC3)N=N2 CCCC[C@H1](O)CCC(=O)N1CC2(CCN(C(=O)[C@H1](OC)[C@H1](C)CC)C2)C1 CC1=CSC(C(=O)N2CCCC[C@H1](N(C)C(=O)CCC(=O)NN(C)C)C2)=C1Cl CCCN1C=C(S(=O)(=O)NCC2(OCCOC)COC2)C(C)=N1 CC(C)N1C=CC(C(=O)NCC2(C)CC(NC(=O)[C@@H1](O)CC(C)(C)C)C2)=N1 CC=1C=CN([C@H1](C)C(=O)N[C@H1]2CCCN(C(=O)C=3C=C(CCO)ON=3)CC2)N=1 NC1=NC=CN=C1C(=O)N[C@H1]2C[C@@H1](NC(=O)C3=CC4=CC=C(Br)C=C4O3)C2 CC1=CN=C(CNC(=O)CCCC2(NC(=O)[C@@H1](F)C(C)C)CCC2)[NH1]1 CC(C)N(C)CC(=O)N[C@H1]1[C@@H1]2C[C@H1]1N(C(=O)C3=C[NH1]C4=CC([N+1](=O)[O-1])=CC=C34)C2 CO[C@H1]1C[C@@H1](CNC(=O)CC2(CNC(=O)[C@@H1](C)C[C@H1](C)C(C)=O)CC2)C1 COC(OC)C(=O)NC1C[C@@H1]2CN(C(=O)C3=CC=NO3)C[C@H1]2C1 C[C@H1](SC1=CC=CC=C1Cl)C(=O)N[C@@H1]2CC[C@@H1]2NC(=O)C=3C=CC(=O)N(C)C=3 CN(CC1=CC(F)=CC(C#N)=C1)C[C@@H1]2CCCN(C(=O)CC(C)(C)C(C)(F)F)C2 CSCCCCC(=O)N[C@@H1]1C[C@@H1]2CN(C(=O)C3=CSC4=CC=CC=C34)C[C@@H1]21 CSC[C@@H1](C)C(=O)N[C@H1](C)CCCCNC(=O)CC1(C(F)F)CC1 COC[C@H1](C)NC(=O)C1=C[NH1]C2=CC(C=3C=NC4=N[NH1]C=C4C=3)=CC=C12 COCCO[C@@H1](C)C(=O)NCC1(NC(=O)CC2=CC=NO2)CCCCC1 CNS(=O)(=O)CCNC(=O)C1=CON=C1[C@H1](C)NC(=O)C2=NON=C2N O=C(C=1OC=NC=1C2CC2)N3CC(NC(=O)[C@@]4(F)C[C@@H1]4C5=CC=CC=C5)C3 CCSCC(=O)N[C@@H1]1C[C@@H1](C)CN(C(=O)CC=2C=CN(C3=CC=CC=C3)N=2)C1 O=C(OCC1=CC=NC=C1)C2=CSC=C2C3=CC=C4C(=C3)NC(=O)CC(=O)N4 CCCC[C@@H1](C)C(=O)NCC1(NC(=O)CCCNC(N)=O)CC2=CC=CC=C2C1 COC1=NC(C)=NC=C1C(=O)NC[C@H1](CC(C)C)NC(=O)C=CC(=O)N(C)C CNC1=CN=CC=C1C(=O)N[C@@]23CC[C@@H1](CN(C(=O)[C@]4(C)CCOC4)C2)C3 CCN(CC(C)(C)CNC(=O)[C@H1]1C[C@H1](O)CN1C(C)=O)C(=O)[C@@H1](C)CS(C)(=O)=O CC[C@@H1](O)CCNC(=O)N[C@H1](C1=CC=C(Br)C=C1)C(F)F CCN(CCCCO)C(=O)C1CC2(C1)CN(CC3=CC(F)=C(OC)C=C3F)C2 CC(C)CC(CNC(=O)C=C1CC1)NC(=O)C COC[C@@H1](O)C(=O)N(C)C[C@H1]1CCCCN1C(=O)CC=CCC2=CC=CC=C2 C[C@@H1]1OCC[C@H1]1CN(C)C(=O)C2=C(CNC(=O)C[C@H1]3CCCCO3)N=NN2C N#CC1=CC=C(OC2=CC=CC(N3CCCC3)=C2)C=C1I C=CC/C=C/CCC(=O)N1C[C@H1](CC(=O)NC(C)C)C[C@H1]1C CCCOCC(=O)N1CCC(N(CCO)C(=O)[C@@H1]2CCC2(C)C)CC1 C=CCCCCC(=O)N(C)[C@@H1](C)C(=O)NO[C@@H1]1CCCN(CC)C1 COC1(CC(=O)N[C@]2(CNC(=O)CCC=3C(C)=NOC=3Cl)CCOC2)CC1 CCN(CC)CC(=O)N[C@@]1(C(=O)NCCOC2=CC=CC=C2)CCC[C@@H1]1C CCCC1=CC(C(=O)NCC[C@H1](O)CNC(=O)C2=CC=C(C)C(OC)=C2)=CC=N1 CC(C)(O)CCNC(=O)[C@]1(F)CCN(C(=O)CNC(=O)C2=CC3=C(S2)CCC3)C1 CC(C)(O)[C@@H1](O)CNC(=O)CO[C@H1]1C[C@@H1](NC(=O)CC2CC=CC2)C1 C[C@H1]1C[C@@H1](NC(=O)C2=N[NH1]C3=CC=C(C4=CC=C(C5CC5)C=C4)C=C23)CCN1C COC[C@H1](O)C1(NC(=O)C2CC3(CC(NC(=O)C4CCN(C)CC4)C3)C2)CC1 C=CC1=CN=CC(C(=O)N2C[C@H1]3CCN(C(=O)C4=CC=C5C(=N4)NCC5)[C@H1]3[C@@H1]2C)=C1 C=CC1(C(=O)NCC=2C=C[NH1]C=2C(=O)N[C@H1](C)C3=CC=NC=C3)CCC1 C[C@]1(C(=O)N2CC(O)(C3=CC=CC(C=4N=N[NH1]N=4)=C3)C2)CNCC1(F)F O=C1CC[C@H1](C(=O)N[C@H1]2C[C@H1](C(=O)N[C@@H1]3CCOC4=CC(F)=CC=C43)C2)N1 CC[C@@H1](C(=O)N1C[C@@H1]2C[C@H1](C1)C2NC(=O)C[C@@H1](CN(C)C)C(F)F)N(C)C C=CC[C@H1](C)NC1=NC=CC(=N[C@H1]2CCN(C3=NC=CC=N3)C2)[NH1]1 C=CCCC[C@@H1](C)NC(=O)[C@@H1](CC(F)F)N(C)C(=O)C=1SC(C)=NC=1C CCC[C@](C)(CC)C(=O)N[C@H1](CC(=O)NCC1=CC=C(Cl)O1)C(F)F CC1(CNC(=O)[C@@H1]2C[C@@H1](F)CN2C(=O)C3=CN=CC=C3C#N)CCOCC1 O=C(COCC1CCC1)NC[C@@H1]2COC[C@H1]2NC(=O)[C@@]3(F)CCS(=O)(=O)C3 O=C(CCCC(=O)N1CC[C@]2(C1)CN(C(=O)C3=CSC(Cl)=N3)CCO2)C4CC4 NC1=CC=C(C(=O)NC[C@H1]2CC[C@@H1](NC(=O)C3=CC4=CC=CC=C4O3)C2)C=C1O CC=1SC=C(C(=O)N2CCC[C@H1](CNC(=O)[C@@]3(C)CCCS3)CC2)C=1N CCC1(CNC(=O)[C@H1]2C[C@H1]3C[C@@H1]2CN(C(=O)[C@@H1]4CCCOC4)C3)CC(C)(C)C1 COC[C@]1(NC(=O)[C@H1](F)C2=CC=CC=C2)CC1(C)C C#CC[C@H1](O)C(=O)N[C@]1(CNC(=O)CCCCN2CCCC2)CCOC1 CN(CCCNC(=O)[C@@H1]1C[C@@H1]2CCCCC[C@@H1]21)C(=O)[C@@]3(C)CCCO3 CC1=CSC(C(=O)N2C[C@@H1](NC(=O)C=C3CC3)[C@H1]4CCC[C@H1]4C2)=C1C CCCN1C(C2=CC3=C(C=C2O)OCCO3)=NN=C1N4CCOC[C@]4(C)C(F)F CCOC1=NC=C(C(=O)N2CC[C@H1]([C@H1](C)NC(=O)C3=CC(C(N)=O)=CS3)C2)C=N1 CC(C)C1(C(=O)N2CCC[C@@]3(CCN(C(=O)[C@@H1]4CC[C@H1]5C[C@@H1]4CO5)C3)C2)COC1 C[C@@H1]1CCCN(C(=O)C2=CC=C(C(N)=O)C=C2)[C@@H1]1CNC(=O)CC[C@@H1](C)N(C)C CC1=C(F)C=C(C(=O)N2CC(N(C)C(=O)CC3=CN=CN3C)C2)C(F)=C1N O=C(N[C@H1]1CN(C(=O)CCC2=CC(Cl)=CC(Cl)=C2)CC3(CC3)C1)C4=CC=NC=C4 CCN(C(=O)CC1=CSC(C#N)=C1)[C@H1](C)C(=O)NCC2(COC)CCC2 CSC1=CC(C(=O)N2C[C@@H1]3C[C@H1]2CN3C(=O)[C@H1]4CCN5C(C)=NN=C5C4)=CC=N1 CC1=CC=C(C)C(C(=O)NC[C@H1]2C[C@@](F)(CNC(=O)C3=CN=CN=C3)C2)=C1 CN1C=C(Cl)C(C(=O)N2CCN(C(=O)CC3CC3)[C@@H1](C4=CC=CN=C4)C2)=N1 C#CCC[C@H1](NC(=O)C1=CC(C)=C(C)S1)C(=O)NC2=CC=C(C#C)C=C2C CC(=O)NC1=CC=C(C(=O)NCC2(CNC(=O)[C@@H1]3CC[C@@H1](C)NC3=O)CC2)C=C1 CO[C@H1](CC1=CC=CC=C1)C(=O)N[C@@H1]2CN(C3=NN=C(C)O3)[C@H1]4CCCC[C@H1]24 O=C(OCCOC1CCCCC1)C2CC(C3CCOCC3)C2 CN1C=C([N+1](=O)[O-1])C(C(=O)N[C@H1]2CC[C@H1]2CNC(=O)C[C@@H1]3CCCO3)=N1 CCOC1=CC=C(NC(=O)C[C@]2(C)CCN2C(=O)[C@H1](C)N(C)C(C)=O)C=C1 O=C(CN(CC=1N=N[NH1]N=1)C2=CC=C(CCO)C=C2)N[C@@H1]3CCCC4=CC=CC=C43 CC1=CC=CC2=C1CCN(C3=NC=C(C)C=C3S(=O)(=O)N(C)[C@H1](C)CC#N)C2 CCC1(CC)C[C@H1](NC(=O)C=2C=C[NH1]C=2C(C)C)CN1C(=O)C3=CN=CS3 CNC(=O)N[C@@H1](C)C(=O)NC[C@H1]1CCN(C(=O)C2(C#N)CCCC2)C[C@@H1]1C CO[C@H1](CC1CCCC1)C(=O)NC[C@H1]2[C@@H1]3C[C@H1]2CN3C(=O)C4=CCCOC4 CCN(C[C@@H1]1CCCCN1C(=O)[C@@H1]2[C@@H1]3CCC(=O)[C@H1]32)C(=O)CSCCC(C)C C#CCN1C=CC=C1C(=O)NC[C@H1](C(=O)NC[C@@H1]2CC[C@H1]2CO)N(C)C C[C@H1](NC(=O)[C@@H1]1[C@H1]2CC[C@H1]3[C@@H1](C2)C[C@H1]31)C4CCN(C(=O)C5=CC=C(C#N)O5)CC4 C[C@@H1]1C[C@@H1](NC(=O)CC2=CC=CC=C2Cl)CN1C(=O)COC3=C(F)C=CC=C3F C[C@H1](NC[C@@H1]1CCN[C@H1](C)C1)C2=CC=C(C(=O)NCCC3CCC3)C=C2 CC(C)(C)CC[C@H1](F)C(=O)N[C@@H1]1CC(C(=O)NC2(C3CCC3)CC2)=C[C@@H1]1O CC(=O)N[C@@H1](C)C(=O)N[C@@H1]1CN(C(=O)C2=CC(Cl)=N[NH1]2)C3(CCC3)C1 O=C1CCNC2=CC(C(=O)N[C@H1]3C[C@@H1](NC(=O)CO[C@H1]4CC4(F)F)C3)=CC=C2N1 COC1=CC=C(NC(=O)[C@@H1](CCSC)N2CCC[C@@H1]2C(=O)NC(C)C)C=C1Cl O=C1CCCN1CC(=O)N2CC[C@H1]3C[C@@]32C(=O)NCC4CCC4 CC=1N=C(C(C)(C)C)SC=1C(=O)NC2CCN(C(=O)C3(F)CCC(C)CC3)CC2 CN(CCNC(=O)CN1C=NN=C1)C(=O)CCCC2=CC(F)=CC=C2F C[C@H1](NC(=O)C=1C=COC=1)C(=O)N[C@@H1]2C[C@@H1]3C[C@H1]2N(C(=O)C4CCCCC4)C3 CCCC=CC(=O)N[C@H1](C)[C@@H1]1CN(C(=O)[C@@H1](CC2CCC2)NC(C)=O)CCO1 C=CCOC[C@@H1](C(=O)NC[C@@]1(NC(=O)COC(C)=O)CCOC1)C(C)(C)C C=CC[C@H1](NC1=NC=NC=2SC(C(C)C)=CC1=2)C3=CC=CS3 CCC=CC=CC(=O)N(C)C[C@H1](O)CN(C)C(=O)CC1=N[NH1]C(=N)S1 COC1=CC=C(F)C(N)=C1C(=O)NC[C@H1](C)NC(=O)COC2(C)CCCC2 CCC(=CC(=O)N[C@H1](C)CCNC(=O)CC1=CN=C2C(=O)[NH1]C=CN12)CC CCC1CCC(C(=O)NC2[C@H1]3CC[C@H1]2CN(C(=O)C4=CC=C(OC)N=N4)C3)CC1 CN1CC2(CC(NC(=O)C=NO[C@@H1](CNC(=O)CCCC3=NC=CO3)C)C2)C1 CC(C)[C@]1(C)CCN1C(=O)[C@H1](CNC(=O)[C@H1]2CC3=CC=CC=C32)CC4CC4 CCS[C@@H1](C)C(=O)N1C[C@@H1](CNC(=O)CC=2C(C)=NN(C)C=2Cl)O[C@H1]3CCC[C@@H1]31 CC(C)(C)C1(C)CC(C(=O)N2C[C@@H1]3C[C@H1](C2)C3NC(=O)C4=CC=CC(N)=C4O)C1 CC1=NSC=C1C(=O)N[C@@]2(C(=O)NC[C@@H1](O)C3=CC=NN3C)CCSC2 CN(C)[C@H1]1CC[C@@H1](C(=O)N[C@]23CCCCC[C@@H1]2N(C(=O)C45CC(C4)C5)CC3=O)C1 CC1=CC=C(F)C(C(=O)N[C@H1](C)CNC(=O)[C@@]2(CO)CCCO2)=N1 CCCN1C=CC=C1C(=O)NC[C@@]23C[C@H1]2CN(C(=O)C=4C=C(OC)N(C)N=4)C3 CN(CC1CCC1)C(=O)CCN(C(=O)CC2CC3(CC3)C2)C4CC4 CN1CC(=O)N(CC(=O)N[C@@H1]2CCN(C(=O)[C@@H1]3C=CCCC3)C[C@H1]2F)C1=O CC[C@@H1](SC)C(=O)NC1CCC(NC(=O)C2=CC3=CC(C)=CC=C3S2)CC1 CCN1CC[C@@H1]1C(=O)N2CC[C@@H1](NC(=O)C(=O)C3=C[NH1]C4=CC=CC=C34)C[C@H1]2C CCC1=C(C(=O)N[C@H1]2CC[C@@H1](N(C)C(=O)C3CC(C)(C)C3)C2)SCCO1 O=C(C1=CC(O)=CC(O)=C1)N2C[C@H1]3C[C@H1](NS(=O)(=O)CC4=CC=CC=C4)C[C@H1]3C2 CC1=N[C@H1](C(=O)N2CCC[C@@](CO)(NC(=O)C[C@@H1](O)C3CCCC3)C2)CS1 C[C@@H1](SC1=CC=CC=N1)C(=O)NC[C@]2(C)CCCN(C(=O)C3(C(N)=O)CC3)C2 O=C(C1=COC(Cl)=N1)N2C[C@@H1](CO)C3(C2)CN(C(=O)C=C[C@H1]4CCCO4)C3 CC[C@@H1](C(=O)N1CCC[C@]2(CCN(C(=O)CN3C[C@H1]4C[C@H1]4C3)C2)C1)N(C)C COCCOC1=CC=NC(N[C@@H1]2CCN(C(=O)[C@@H1]3CS(=O)(=O)CC(=O)N3)C2)=N1 CCOCCN1N=NN=C1[C@@](C)(C[C@H1]2CCCCN2C)NC3(C)CCOCC3 CCC=1OC=NC=1C(=O)N[C@@H1]2[C@H1]3CCN(C(=O)CC=4SC(C)=NC=4C)CC[C@H1]32 CC(C)/C=C/CCC(=O)N[C@@H1]1C=C[C@H1](CNC(=O)[C@@H1](C)NC(=O)C=2C=COC=2)C1 C=C[C@@H1]1C[C@H1]1C(=O)N2C[C@H1](OC)C[C@H1]2CNC(=O)C3=CC=C(OCCF)C=C3F CS[C@H1](C)C(=O)N1CC[C@H1](OCCNC(=O)COC2=CC=C(F)C=N2)C1 CC1=CC(C(=O)NCC[C@H1](C)NC(=O)CC(C)(F)F)=C(C)N1[C@H1]2CCCOC2 CO[C@@H1](C)C1CN(C(=O)CCC(C)(C)NC(=O)C2=CN=C(O)C(F)=C2)C1 CC1=CN=CC=2C=C(C(=O)N[C@@H1]3CCN(C(=O)C4CSC4)C[C@@H1]3O)SC1=2 CCC1=CC(NC(=O)C[C@@H1]2CN(C(=O)C3CS(=O)(=O)C3)C[C@H1]2CC)=CC=C1F CC1=CC=CC(CC(=O)N[C@H1]2C[C@@H1]3CCC[C@H1](C2)N3CC4=CC=C(Br)C=C4)=N1 CN(CC1=CC=CC(CNC(=O)C2CC(F)(F)C2)=C1)C(=O)[C@@H1]3C[C@H1]3Cl C[C@@H1](CC(=O)N[C@H1]1COC[C@H1]1NC(=O)C2=CC=C(C3CC3)O2)CN(C)C CC1(C)C[C@H1]1C(=O)N2CC[C@@H1](CNC(=O)C3=CC=C(CCO)C=C3)C(F)(F)C2 O=C(N[C@H1]1C[C@@H1](O)CN(C(=O)C=2C=NN(CC3CCC3)C=2)C1)C4=CC=NC=C4O CC[C@@](C)(CO)C(=O)N1CCC(COC)(NC(=O)CNS(=O)(=O)CC)CC1 CCC[C@@H1](CNC(=O)COCC1=CC=CC=N1)NC(=O)[C@@H1]2[C@H1]3CCCC[C@H1]32 COCC1(C(=O)N[C@H1](C)C2=NOC=C2C(=O)N3CCCCCC[C@H1]3C)COC1 C[C@@H1]1C[C@H1](C(=O)NCCC2CSC2)CN(C(=O)C3=CN(C)C(=O)N3C)C1 CN(CC1CCOCC1)C(=O)C(=O)N2CCCC[C@H1]2CN3CCOCC3 C=CC[C@@]1(NC(=O)C2=CC=C3OC(O)=NC3=C2)CCN(C4=NC=CC(SC)=N4)C1 O=C(NC[C@H1]1CCOC1=O)[C@@H1]2CCCN2C(=O)[C@]3(O)CCOC3 COC(=O)[C@H1]1N(C(=O)[C@]2(C)CN(C(=O)[C@H1](O)C3CCCC3)C(C)(C)C2)CC1(C)C CC(C)(C(=O)N[C@@H1]1CC[C@H1]2CCN(C(=O)COCCF)[C@H1]2C1)N3CCOCC3 C[C@H1]1CCC[C@H1]1CC(=O)N2C3CCC2(CNC(=O)C4=CC=CC=5OC=CC4=5)CC3 C[C@H1]1CN(C(=O)CSCCNC(=O)CCCCC#N)CC[S@@]1=O CSCCCCCCC(=O)NCC[C@H1]1CCCCN1C(=O)[C@@H1]2CCCN(C)C2 C[C@H1](C(=O)N[C@@H1]1CC[C@H1](CO)C1)N(C(=O)CCC2=CC=CS2)C3CC3 CC1=CC(CCC(=O)N2C[C@H1](C)[C@H1](NC(=O)C3=CC(O)=C(F)C=C3N)C2)=NO1 CCO[C@@H1](C(=O)NC[C@H1]1C[C@H1]1NC(=O)C2(CC3=CC=CC(F)=C3)CC2)C4CCC4 CC(C)(C)/C=C/CC(=O)N1C[C@H1](NC(=O)/C=C/C2=CC=CC=C2)[C@@H1](C3CC3)C1 O=C(NC[C@H1]1C[C@@H1]1C2=CC=CO2)[C@@H1](F)CC3CN(C(=O)C4=CC=CC(O)=C4F)C3 CCN(C(=O)C1=CC(C)=CS1)[C@H1](C)CNC(=O)C#C[C@@]2(C)CCCO2 CCC[C@H1](CNC(=O)C1=CC[C@@H1](C)CC1)NC(=O)CC2=CC(F)=CC=C2O CC[C@@](C)(OC)C(=O)N1CCC[C@](C)(NC(=O)CC2(CO)CC2)C1 C[C@@H1]1[C@@H1](C)N(C(=O)CSS(C)(=O)=O)CCN1C(=O)C2=CSC3=CC=CN=C23 CCN(C(=O)CN1C=CC=N1)[C@@H1](C)CNC(=O)C=2C=C(C3=CC=C(F)C=C3)ON=2 C=CCCO[C@H1](C)C(=O)N[C@@H1]1CN(C(=O)C2=CC=C(C3CC3)N=C2)C[C@H1]1SC CCOC(=O)[C@@H1]1CC[C@H1](NC(=O)N2CC(CC3=CC=C(Cl)C=C3)C2)C1 CO[C@@H1](C)[C@H1](O)C(=O)N1CCC(NC(=O)C2=CC=C(N3C=NN=N3)C=C2)CC1 CN(CC(C)(C)N(C)C)C(=O)C[C@@H1]1[C@@H1](NC(=O)[C@@]2(C)CCCCO2)C[C@H1]1O CCCCC(=O)NC[C@H1](C)CNC(=O)C1=CC=C(O[C@@H1](C)CC)C=C1 CCC[C@H1](OCC)C(=O)N1C[C@@H1](CN(C)C(=O)CCC2=NC(=N)[NH1][NH1]2)C3(CC3)C1 CCCSCC(=O)NCCC(O)(CN(C)C(=O)C=1C=C[NH1]C=1C2=CC=CC=C2)C CN1CCC[C@@H1](CCC(=O)NC[C@H1](O)CN(C)C(=O)C2=CC(Cl)=NS2)C1 CC1=CC=CC(CN2CCC(CC(=O)NC3=NC=CC=C3CCO)CC2)=C1 CO[C@@H1](C)CC(=O)N1CC=C(CC(=O)N[C@H1]2CCNC2=O)CC1 CSC=1C=C(C(=O)N[C@H1](C)[C@H1](C)NC(=O)C=2SC=CC=2C(C)=O)OC=1C CC(C)C=1C=COC=1C(=O)N[C@@H1]2C[C@H1]3C[C@H1]2CN3C(=O)C4=CN=C5N=CC=CN45 C=CC1=CN=CC(C(=O)N[C@@H1]2CCOC23CCN(C(=O)C4=CC=NO4)CC3)=C1 CC(C)C(C)(C)CN=C1N=C(N2[C@H1]3CC[C@@H1]2C[C@H1](CO)C3)C4=C([NH1]1)CCS4 COC[C@@H1]1CN(C(=O)C(C)(C)C2CCC2)CCN1C(=O)C[C@@H1](C)N3CCCC3=O CN(C)[C@H1](C(=O)NCCN(C(=O)CC=1C=C[NH1]C=1)C2CCC2)C(C)(C)C C[C@@H1]1C[C@@H1]1CCNC(=O)CN(CC2CC2)C(=O)CCN3C=CC=C3 CN(C[C@H1]1CCN(C(=O)C2=CN=CS2)C1)C(=O)[C@@H1]3CCC4=C(C=NN4C)C3 CO[C@H1](C)CC(=O)NCC[C@H1](CNC(=O)[C@@H1]1CC1(Cl)Cl)OC CC[C@H1](O)C1=CN([C@H1]2C[C@H1](NC(=O)C=CSC)C2)N=N1 C[C@@H1]1C[C@@H1]1CN(C)C(=O)C2CC(N(C)C(=O)[C@H1]3COC(=O)N3)C2 CC1=CC=CC=C1C(=O)N[C@@H1]2CCC[C@H1](NC(=O)[C@H1]3CCC4=NN=NN4CC3)C2 CCCS(=O)(=O)CC(=O)N1C[C@@H1](NC(=O)C[C@H1](C)C=2C=NN(C)C=2)C3(CC3)C1 CC1=CC=CC=C1C(C)(C)C(=O)NC[C@]2(C)CN(C(=O)C3CCC3)CCO2 C=C(Br)CC(=O)N1CCN(C(=O)C2=CC=C(O)C=C2)[C@H1]3CCC[C@]3(C)C1 CC1(NC(=O)[C@@H1]2C[C@H1]3C[C@@H1]2CC3(F)F)CC(NC(=O)C4=CC(F)=CC=C4F)C1 CN1N=C2C=CC=C(CNC(=O)[C@@H1]3COCCN(C(=O)C4(C(N)=O)CC4)C3)C2=N1 C[C@H1](CS(C)(=O)=O)N(C)C(=O)NC1=CC=NN1CC2=CC(C#N)=CC=C2Br CC=1C=C(C)N(CC(=O)NCC2=CC(C(=O)N3CCC[C@](C)(C#N)C3)=N[NH1]2)N=1 CC(C)(C)[C@@H1]1CCC[C@H1](C(=O)NCC2(O)CN(C(=O)C(=O)NCCC(N)=O)C2)C1 CCCCCCCC(=O)NC[C@@]1(O)CCN(C(=O)C=2C=NOC=2C3CCC3)C1 CC(C)[C@@H1](C(=O)N1[C@H1]2CC[C@@H1]1C[C@H1]2NC(=O)[C@H1]3CCS(=O)(=O)N3)N4C=NN=N4 CCOC1=CC=C(CN(C=O)[C@@H1](CO)[C@@H1]2CC=CCC2)C=C1C CNC(=O)C1=CC=C(C(=O)N2CC(O)(CNC(=O)C=3C=C(C(C)C)ON=3)C2)C=N1 CO[C@H1](C(=O)N1CCN(C(=O)C23CCC(O)(CC2)CC3)C[C@@H1]1C)C(C)C CC(C)N(C)CC(=O)NCC=1N=NN(C)C=1C(=O)N2CC(OCCF)C2 C=CCCN1C=C(C(=O)N2CCC(=CCNC(=O)[C@@]3(OC)CCOC3)CC2)N=N1 O=C(NCC1=CC=NC=N1)[C@@H1]2C=CCN2C(=O)C3=CC=CC4=NC=CN34 CC=1C=C(C(=O)N2CC(C3CCN(C(=O)[C@@H1]4CCN4C5CCCC5)CC3)C2)SN=1 CC=1C=C(CCC(=O)N2CCO[C@H1](C(=O)N=C3C=C[NH1][NH1]3)C2)ON=1 C[C@@H1]1C[C@H1](CNC(=O)CCSC2=CC=CC=N2)CN1C(=O)C3=NN=CS3 O=C(CCSC1=CC=CC=C1)NC[C@H1](O)CNC(=O)CN2C=NC3=CC=CC=C32 CC(=CC1=CC=CO1)C(=O)N2CC[C@@H1](NC(=O)C34CCCC3CCC4)[C@H1](F)C2 CCC1=CC(O)=CC=C1NC(=O)CN2C=C(CNC(=O)[C@@H1]3CCNC3=O)N=N2 COCCCCC(=O)N1C[C@H1]2C[C@H1](NC(=O)C3=CC(C)=C(C)C(C)=C3)C[C@H1]1C2 C#CCOCC(=O)N[C@H1](C)C1=CN(CCN2CCC3=CC=CC=C32)N=N1 C=CCC1(C(=O)N(C)CCCC(=O)N2CC3(CCCCC3)C2)CC1 COC1=CC(OC)=C(C(=O)N[C@@H1]2CN(C(=O)C=3C(Cl)=CSC=3Cl)C[C@H1]2C)C=N1 CN(CCC#N)C1=CC=C(CN[C@@H1](C2=CC=CC(Cl)=C2)C(F)F)C=C1 CC1=CC=CC=2C(CC(=O)N[C@H1](CO)CNC(=O)[C@H1](O)C3CCOCC3)=C[NH1]C1=2 CC(C)=C(C)C(=O)NCC1=NC([C@@H1]2CCCN(C(=O)[C@@H1](CCO)N(C)C)C2)=N[NH1]1 CCN1N=C(C(=O)N2CC[C@H1]3CCC[C@@]32CNC(=O)C=4SC=NC=4C)C=C1O CC[C@@H1](C)C(=O)N1[C@H1]2CC[C@@H1]1C[C@@H1](NC(=O)C3=CC(N)=CC=C3Br)C2 COCCC[C@H1](NC(=O)CSCCOC)C(=O)N[C@@H1]1CCCCC1(F)F CC=1C=C(C(=O)N[C@@H1]2C[C@H1]3CC[C@H1]2CN3C(=O)C4=C[NH1]C5=NC=CC5=C4C)ON=1 O=C(NC1=CC(Cl)=NC=C1Br)C2=CC=C(C3=CC=C(C(=O)NC4CC4)C=C3)N=N2 CC=1C=CN2C=NN=C2C=1NC(=O)N[C@H1]3C4=CC=CC=C4CC35CCCC5 COCC=CC(=O)NC[C@@H1]1CCCC[C@@H1]1NC(=O)C2=CC(N)=C(OC)C=C2F CCN1C=NC(C(=O)N2CCCO[C@@H1](CNC(=O)C3=CC=CN4N=NC=C34)C2)=C1 COC1CC2(CC(NC(=O)C(C)(C)[C@H1]3CCCN3C(=O)C[C@H1]4CCCN4C)C2)C1 CC1=NC(C(=O)N2CCC(N(C)C(=O)CSC3=NN=CS3)CC2)=C(C)O1 C[C@@H1](NC(=O)C1C=CC=CC=C1)C2=NOC=C2C(=O)N3CCN(C4CCC4)CC3 C[C@H1](CCCCNC(=O)C=1C=C2N(N=1)CCCN2)NC(=O)[C@@H1]3CCC[C@@H1](F)C3 C[C@@H1]1CCN(C(=O)[C@@H1]2CC3=CC(Cl)=CC=C3O2)[C@H1]1CNC(=O)CN4C=CC=N4 CC(C)(C#CC(=O)N1CC[C@@H1](CO)[C@H1](O)C1)CNC(=O)[C@@H1]2C[C@@H1]3CC[C@@H1]3C2 CN(C)C[C@@H1]1CCC[C@@H1]1NC(=O)C=2C=C(CNC(=O)C3=CN=NN3C)ON=2 COCCN(C)C[C@@H1]1CCCN1[C@H1](C(=O)NC2(C)CC2)C3=CCCSC3 COCC(=O)N(C)CC(=O)NC[C@@]1(COC)CCN(C(=O)C=2N=NSC=2N)C1 CC1=CC(C)=CC(NC(=O)[C@@H1](F)C2CC(NC(=O)CC3=CN=CC=C3C)C2)=C1 C1C=CC(C(=O)NC[C@@H1]2CN(C(=O)[C@@H1](C)N3CCSCC3)CCCO2)=CS1 CCCC[C@H1](CN=C1[NH1]C=CN=C1F)NC(=O)CC2=CC(C)=CC=C2OC O=C(CCC=1C=N[NH1]C=1)NC[C@H1]2C[C@@H1](O)CN2C(=O)CCN3CCC3 C[C@]1(NC(=O)CCNC(=O)C2=NC=C3C=CC=CN23)CCSC1 C#CC[C@H1](O)C(=O)NCCNC(=O)[C@H1]1CC[C@@](C)(O)CC1 C#CCOCC(=O)NC(C)(C)/C=C/C(=O)NC[C@@](C)(O)CSC CC1=CC=C2N=CN(CC(=O)NCC3(CNC(=O)[C@H1](C)C(C)C)CCCC3)C2=C1 CN(C(=O)C1(N(C)C)CCCC1)C2(C(=O)NC[C@@H1](C3CC3)N(C)C)CC2 COC1=CC(CN(C(=O)[C@H1](C)Br)C2CC(CO)C2)=CC3=C1OCO3 CC=CC=CC(=O)N[C@]1(CNC(=O)CN2CCCS2(=O)=O)CCOC1 CCC(=O)N1CCN(C(=O)CN(C)C(=O)C[C@@H1]2CSCCS2)CC1 C[C@H1](C(=O)N[C@H1]1CC[C@H1](CN2C=CN=C2)C1)N3C=C(CCCN(C)C)N=N3 CCCC(C)(CCC)C(=O)N1CC[C@H1](C)[C@@H1](NC(=O)CCC(C)(C)F)C1 COCCN(CCNC(=O)C1=CC(F)=CC(F)=C1)[C@@H1](C)C2=CC=CC(C)=C2 CCC1=NN=C(CNC(=O)[C@H1]2COCC[C@@H1]2NC(=O)C(=O)C3CCOCC3)O1 C#CCCC(=O)N1CCCCC[C@@H1]1CNC(=O)C[C@H1]2CCCC(C)(C)C2 C=C(C)CC(=O)NC1(CNC(=O)C2=CC=3OC(C)=C(C)C=3[NH1]2)CCCC1 C=C(C)COCC(=O)NC[C@H1]1CN(C(=O)CC[C@H1]2CCOC2)[C@H1]3CCN1C3 CCN1CCOC[C@@H1]1CC(=O)N2CC[C@@H1](NC(=O)C=3C=NC4=NC=NN4C=3C)C2 CC(C)N(C)C(=O)C[C@H1]1CCCCN1C(=O)C2=CN(C)C=N2 C[C@@H1]1CC2=CC(C(=O)N(C)C[C@H1]3CCCN3C(=O)[C@@H1]4CC4(Cl)Cl)=CC=C2O1 CC(C)(O)C(=O)N[C@H1]1C[C@H1]2CC[C@H1]1N(C(=O)C3=CC=C([N+1](=O)[O-1])S3)C2 O=C(CCOC1COC1)NCC2=CC=C(CNC(=O)COC[C@@H1]3CCCCO3)O2 CCCCN(CCO)C(=O)[C@@H1](C)NC(=O)C=1C=C[NH1]C=1CC CCN(CC)C1=CC=C(C(=O)NC[C@]23C[C@@H1]2CN(C(=O)CC4=CC=NO4)C3)C=N1 C[C@@H1]1C[C@H1](C(=O)NC2CC3(CNC(=O)O3)C2)CCN1C(=O)C=4C=CSC=4Cl CC(C)CC(=O)NCCC(=O)N[C@H1]1CCCN(C(=O)C2=CC=3OC=CC=3S2)C1 COC1=CC=C(C(=O)N(C)CCN(C(=O)CC[C@@H1]2CCC(=O)N2)C(C)C)S1 C[C@]1(CNC(=O)C2=CC=NC(F)=C2N)CC[C@@H1](NC(=O)C3=COC(Br)=C3)C1 CC=1C=COC=1C(=O)N2CCN(C(=O)C[C@@H1]3C[C@H1](O)C34CCC4)[C@H1](C)C2 CC=1C=CSC=1C(=O)NCC2=CC=CC(CNC(=O)C3=CC4=NC=CC=C4[NH1]3)=C2 CC1=CN=C(C(=O)NC[C@@H1](F)C2CCN(C(=O)[C@](C)(O)C(C)C)CC2)C(F)=C1 CCNS(=O)(=O)CC(=O)N1CC(C)(NC(=O)C2=CN(C3=CC=C(Cl)C=C3)N=N2)C1 O=C(C1=CC=C(OCCCO)C=C1)N2CCC(C3(NC(=O)[C@H1]4CC4(Cl)Cl)CC3)CC2 CC1=CC(C2=CN=C3C(C(=O)NC(C)(C)CO)=C[NH1]C3=C2C)=CN=C1O C#CCCCC(=O)NC[C@@H1](CNC(=O)C=1SC=CC=1SC(F)F)OC C=CC[C@H1](C(=O)N1CC[C@@](C)(NC(=O)C=2C=C3N(N=2)CC4(CC4)C3)C1)C(C)C COC(=O)NC(C)(C)C(=O)N1CCC(C2(O)CN(C(=O)C3CCO3)C2)CC1 CCCCO[C@H1](C)C(=O)NCC[C@H1]1CCN(C(=O)C2=CC=3C=CSC=3C(O)=N2)C1 COC(=O)CN1CCC[C@H1](CN[C@@H1](C2=CC=C(OC)C(Br)=C2)C(F)(F)F)C1=O COC(=O)[C@@H1](NC(=O)[C@@H1]1C[C@@H1]1CF)[C@@H1]2CCS(=O)(=O)C2 CC(=CC1=CC=CC=C1)C(=O)N2CC=C[C@@]2(C)C(=O)N3CCN(C)C[C@H1]3C O=C(CC1=CN=C(C(F)(F)F)S1)NC[C@H1]2C[C@@H1]2NC(=O)C3(F)CCOCC3 C=C=C(C)CC(=O)NC[C@@](C)(CC)NC(=O)[C@@H1](C)CCCCCCCC CN1N=NC2=C1CC[C@@H1](C(=O)N[C@@H1]3C[C@@H1]3NC(=O)CCCN4C=CN=N4)C2 CC[C@@H1](NC(=O)CNC(=O)C[C@@H1]1CCC[C@H1](C)O1)C2=CC=NC=C2 CCC1=CC=CC=C1[C@@H1](CNC(=O)CCC2=CSC=N2)NC(=O)[C@@H1](CC)OC CCOC[C@@H1]1CCCCN1C(=O)[C@@H1]2CCC[C@@H1]2NC(=O)OCC COC1=CC(C(=O)N2CC(CNC(=O)[C@]3(C)CCC4=CC=CC=C43)C2)=CC=C1F CC1=NC=CC=C1CC(=O)N2CCC[C@H1](NC(=O)C3=N[NH1]C4=C3CCSC4)CC2 O=C(NCC[C@@H1]1CSCCN1C(=O)C[C@H1]2CCCOCC2)C3=CN(C4CC4)C=N3 CC1=CN=C(C(=O)N2CC[C@H1](NC(=O)C3=C(O)N=NC(C)=C3C)[C@@H1](F)C2)C=C1C CC1=NC(CCN(CCCNC(=O)[C@H1]2CC3=CC=C(F)C=C32)CCOC)=CS1 CNC1=CC=C(C(=O)N2CC(O)(CCNC(=O)C(C)(C)C3=NN=CN3C)C2)N=C1 O=C(CSC1=CC=NC=C1)N[C@@]23CCN(C(=O)C4(F)CCCCC4)C[C@H1]2C3 CN(C)C[C@@H1](O)C(=O)N1CC[C@]2(CCCN(C(=O)C3=C(F)C=C(O)C=C3F)C2)C1 COC[C@@]1(NC(=O)CC2=NON=C2C)CCCN(C(=O)C3=CC(OC)=CC=N3)C1 CC1=NO[C@H1](C(=O)NCC[C@H1]2CN(C(=O)C=CC=3C=C[NH1]N=3)CCCO2)C1 COC(=O)[C@H1](CNC(=O)[C@H1]1CN(C(=O)[C@]2(F)CCOC2)CC1(F)F)OC CC1(CNC(=O)C[C@@H1]2CCCN2C(=O)CSC3CC3)CCC(O)CC1 O=C(N[C@@H1]1CCCOC12CCCC2)[C@H1]3CCN(C4=CC(Cl)=CC(Cl)=C4)C3=O COCCN1N=NN=C1[C@@H1](NC=2C=NN(C(C)C)C=2)C3=CC(Br)=NN3COC CCCN(C(=O)C1=NC=NC=2C=C[NH1]C1=2)C3CCN(C(=O)C4=CC=CC=N4)CC3 NS(=O)(=O)CCNC(=O)[C@@H1]1C[C@H1](NC(=O)[C@H1]2CCCCO2)CCO1 CC1=NC2=CC=C(CN3C[C@@H1](C)C[C@H1]3C(=O)NC4=CC=CC(C#N)=C4F)C=C2O1 C=CC(C)(C)CC(=O)NC[C@@H1]1CCC2(CCN(C(=O)C3=CC=CC=C3C)CC2)O1 CCN1N=C(C)C=C1C(=O)N2CC[C@H1](CC(=O)NCCCCCN=[N+1]=[N-1])C2 COC1=CC=C(/C=C/C(=O)N[C@@]23CCCC[C@@H1]2CN(C(=O)[C@H1](C)SC)C3)C(F)=C1 C=CCNC(=O)NC(=O)CN1C[C@@H1]2[C@H1](C1)[C@@H1]2NC(=O)OC(C)(C)C COC(=O)C1=CC=CC(C2(F)CN(C(=O)[C@@]3(C)OC(=O)C4=CC=CC=C43)C2)=C1 COC1=CC(F)=CC(C2=CC=C3OC(C(=O)NC4=CC(Cl)=CN=C4Br)=C(C)C3=C2)=C1 CN1N=NC2=C(C(=O)N[C@@H1]3CCCN(C(=O)C4=CC=NC=C4)C[C@@H1]3F)C=CC=C21 C[C@@H1](NS(C)(=O)=O)C(=O)NC[C@H1]1CN(C(=O)CC2=CC=C(Cl)N=C2)CCN1C O=C(COC1CC(F)(F)C1)NC[C@@]2(F)CCCN(C(=O)C[C@@H1]3CCCC3(F)F)C2 O=C(CC[C@H1]1CCOC1)NCCSCC(=O)NCCN2C=NC=N2 O=C(CCNC(=O)C(C1CC1)C2CC2)N3CCOCC4(CC4)C3 COC1=CC=NC(O)=C1CNC(=O)NCCN(C)CC2=CC3=CC=CC=C3O2 C=CCCCC(=O)N[C@@H1](CO)CNC(=O)[C@@H1]1CC2(CO1)CN(C(=O)OC(C)(C)C)C2 C[C@@H1]1CCN(C(=O)[C@@H1](C)N2CCCC2)CCN1C(=O)C3=CC=C(SC(F)(F)F)O3 C[C@@H1](C[C@@H1](C)C(F)F)NC(=O)C1CCN(C(=O)CCCN2C=CN=N2)CC1 CC=1C=CN2C(=O)C=C(CN(CC(=O)NCC(F)(F)F)CC(C)(C)C)N=C2C=1 CC1(C)CO[C@H1](CC(=O)NCC[C@H1](O)CNC(=O)C2=CN=CC=C2Br)C1 C[C@@H1](OCC1CC1)C(=O)N(C)CC(=O)NCCCC2CCOCC2 CC1=CC=C(C(=O)N(C)[C@H1](CC(F)F)C(=O)N2CCC[C@@](C)(C#N)C2)N1C CC(C)=CC(=O)N(C)C[C@H1]1[C@@H1]2CN(C(=O)CNC(=O)C=3C=COC=3)C[C@H1]12 COCC(C)=CC(=O)N1CC(=O)NC[C@H1]1C(=O)N2CCC=3C=CSC=3C2 CC=1[NH1]C(C)=C(C(=O)N2CCC[C@H1]([C@@H1]3CCN(C(=O)C4=CN=NS4)C3)C2)C=1C C[C@@H1](C(=O)NC(C)(C)C#CC1=CN(CCCCCCO)N=N1)N2C=CN=C2 CC(C)S[C@H1](C)C(=O)N(C)[C@@H1]1CN(C(=O)C2=CC=C(SC(F)F)C=C2)C[C@H1]1F CC(=O)NCC(C)(C)C(=O)NC1=CN(C)N=C1OCC2CC2 CC(C)(CNC(=O)[C@@H1](O)CC1=CC=CC=C1Cl)CNC(=O)[C@@H1]2C[C@H1]2F CC[C@](C)(CCNC(=O)[C@H1]1CCCC2=C[NH1]N=C21)NC(=O)C3=COC(C4CC4)=N3 C#CCCN(C)CC(=O)N[C@H1](C)CCN(C)C(=O)[C@H1]1CCCC12CC2 C=CCOC1=CN(C2=CC=CC=C2)N=C1C(=O)N[C@H1]3C[C@H1]4CC[C@H1]3N(C)C4=O CCC1=NC=C(Cl)C(C(=O)NC2(C)CC(NC(=O)C3=CC=CC=[N+1]3[O-1])C2)=N1 C[C@@H1](OCC1CC1)C(=O)N[C@@H1]2[C@H1]3CCN(C(=O)C4=CC=C(N5C=CN=C5)C=C4)[C@H1]32 CCC[C@H1](C(=O)N1CC[C@@H1](NC(=O)C2CCC(F)(F)CC2)C1)N3C=CC=C3 COC1=NC=C(C(=O)N(C)C[C@@H1](C)N(C)C(=O)[C@H1]2CCCOC2)C3=CC=CC=C13 C=CC[C@H1](CNC(=O)[C@@H1](C)CF)C(=O)N1CCC[C@H1]1CC2CCC2 CCC1=NC=CN=C1C(=O)N[C@H1]2CC[C@H1](C)N(C(=O)C=3C=NN(C4CC4)C=3C)C2 COC[C@@H1](C)NC(=O)C[C@H1]1CCCN(C(=O)[C@H1]2OCCO[C@H1]2C)C1 C=CC1CCN(C(=O)[C@H1]2CC[C@H1]2CNC(=O)CNC(=O)CCC)CC1 CC[C@@H1](C)C1=CC=C(C(=O)N2C[C@@H1]3C[C@@H1](NC(=O)C4=CN=C(S)N4C)[C@H1]2C3)C=C1 CCOC1CC2(C1)C[C@H1]2C(=O)N[C@H1]3CCN(C(=O)[C@H1]4CC[C@H1](C(F)(F)F)CC4)C3 CC[C@H1](CC1CCCCC1)C(=O)N[C@H1](CO)[C@H1](C)NC(=O)[C@@H1]2[C@H1]3CCC[C@H1]32 CC=1C=C(C)N(CC(=O)N2CCC[C@@](O)(CCNC(=O)C=3ON=CC=3C)C2)N=1 CCC[C@@H1](C)C(=O)N(C)CC1(CNC(=O)[C@@H1]2CCCN2C(=O)OC(C)(C)C)CC1 O=C(C1=CC=C(C2=NC=CS2)N=N1)N3CCN(CC(F)(F)F)CC3 CCOC1=CN=C(C(=O)N[C@H1]2CCC[C@H1](NC(=O)CCCNC(C)=O)C2)C(Cl)=C1 CCOC1=CC=C(C)C=C1C(=O)NC[C@H1](CC)NC(=O)C[C@@](C)(C(F)F)N(C)C C[C@@H1]1C(=O)N(C)CCN1C(=O)C2=N[NH1]C3=CC=C(C=4SC=NC=4C5CC5)C=C23 CSC(C)(C)CC(=O)N[C@H1]1CCC[C@]12CCN(C(=O)C3=C(F)C=CC(C)=C3F)C2 CCC[C@@H1]1C[C@H1]1C(=O)NCCC(C)(C)NC(=O)C2=CC(=O)C(OC)=CO2 O=C(O)C1=COC(C(=O)N2C[C@H1](S(=O)(=O)F)CC[C@@H1]2C3=CC=CC(Cl)=C3)=C1 CCS[C@@H1](C)C(=O)N[C@H1]1C[C@H1]2C[C@@H1](NC(=O)COCC=3C=C(C)ON=3)C[C@H1]2C1 CS[C@H1](C)C(=O)N1CCC[C@H1](NC(=O)CCOCC(F)(F)C(F)(F)F)[C@@H1]1C O=C(NCCCN1C=NC=N1)[C@@H1]2C[C@H1](O)CCN2C(=O)[C@@H1]3CC=CCC3 C=C1C[C@@H1]1C(=O)N2CC3(CCN(C(=O)[C@]4(C)CC=C(C)CC4)CCO3)C2 CCC(C)(C)[C@@H1](O)C(=O)N(C)C[C@@H1](O)CN(C)C(=O)CN(C)C(C)C C[C@@H1](C(=O)N[C@@H1](C(=O)N(C)CC(C)(C)CN(C)C)C1=C(O)C=CC=C1F)N(C)C CCC1=CC=C(N2C=C(C(=O)N[C@@H1](CNC(=O)[C@H1]3C[C@@H1]3C)C4CC4)N=N2)C=C1 CC(C)(C)[C@@H1]1C[C@H1](CC(=O)NC2CC(NC(=O)C3(C(C)(C)O)CCC3)C2)C(=O)N1 O=C(O)C1=CC(C=C2CN(C(=O)C3=CC=C(Br)C=C3F)C2)=NO1 O=C(C=CCO)NCC1(O)CCN(C(=O)C[C@@H1]2CCC[C@H1](C(F)(F)F)O2)CC1 CC(C)(C)OC(=O)C(C)(C)C(=O)N(CCCNC(=O)CCOCC(F)F)C1CC1 CN1[C@H1]2CC[C@H1]1CN(C3=NC(=NCC4=CC(Cl)=CC=C4Br)[NH1]C=5N=CN(C)C3=5)C2 C[C@H1]1CN(C(=O)C=2C=C(C3CC3)ON=2)C[C@H1]1NC(=O)C=4C=CC5=NN=C(O)N5C=4 CCN(CCC(N)=O)C(=O)C1CCC(N2C=C(C3=CN=CC(Cl)=C3)N=N2)CC1 CO[C@H1]1C[C@@H1](CNC(=O)C23CCC(CC2)N(C(=O)[C@@H1](C)C(F)F)C3)C1 CC(C)(C)OC(=O)N1CC[C@H1]2CCC[C@]21CNC(=O)C3=CC(Cl)=C[NH1]3 CC=CC(=O)N1CCC[C@@](CCC)(NC(=O)CNC(=O)NCC2=CC=CO2)C1 CC1=CC(F)=C(CN2CCC[C@H1](NC(=O)/C=C/C3CCCCC3)CC2)C(F)=C1 C=C[C@](C)(O)CC(=O)N1CCCC[C@H1]1C2(NC(=O)CCCCN(C)C)CC2 CC[C@@H1]1C(=O)NCCN1C(=O)[C@@H1]2CCOCCN2C(=O)C3CC(=O)C3 CC[C@@H1](OC)C(=O)NC[C@@H1]1CCN(C(=O)C2=CC=CC(C3CC3)=N2)C14CC4 CC(C)(CCC(=O)NCCOCCCF)NC(=O)C=CC1=CC=CC=C1 CC(C)(C)OC(=O)N1CCCC12CCN(C(=O)CC=3C=C[NH1]C=3)CC2 CC(=O)NC1(C(=O)NC[C@]23CC[C@H1]2CN(C(=O)CC=4C=CSC=4)C3)CCCCC1 OC1=CC=CC2=C1CCN(CC3=CC(F)=NC=C3Cl)CC2 C[C@H1]1OCC[C@@H1]1CC(=O)NCC(=O)NCC2=CCN(C)CC2 CC(CCNC(=O)[C@@H1]1CNC[C@H1]1C(C)C)CN(C)C N#CC1=CC=CC(CS(=O)(=O)N(C2=CC=C(O)N=C2)[C@H1]3CCCC34CCNCC4)=C1 CN(C(=O)COC1CCCCC1)[C@H1]2[C@@H1]3CN(C(=O)[C@@]4(CC5CC5)CCCO4)C[C@@H1]32 CC(C)[C@H1]1CC[C@H1](C(=O)NCCCC[C@H1](C)NC(=O)[C@]23CSC[C@H1]2C3)CC1 C=CC1(CC(=O)N[C@@H1](C)C=2C(C)=NOC=2C)CN(C(=O)CCC3=CC(C)=NO3)C1 CC[C@H1](C(=O)NC[C@H1]1C[C@@H1](NC(=O)C(C)(C)C(F)(F)F)C1)C=2C(C)=NOC=2C CC1=C(C(=O)NCCC2CC(NC(=O)C3=CC=C(F)S3)C2)C=NN1CCN(C)C CCCCCC(=O)N1C[C@@H1]2C[C@H1]1C[C@H1](NC(=O)C3CC(C(C)C)C3)C2 CC(=O)NCC(=O)N1CC[C@@H1]2CCC[C@]21C(=O)NCCO[C@@H1]3C[C@H1]3C CCCC1=C(C(=O)N2[C@@H1]3CN(C(=O)[C@]4(C)CC=CCC4)C[C@@H1]3C[C@H1]2C)N=NN1C CCO[C@H1](C(=O)N1CCCC[C@@H1](CNC(=O)C2=CC=3SC(Cl)=CC=3S2)C1)C4CC4 CCC(CC)[C@H1]1CCN(C(=O)C(C)(C)[C@@H1](C)NC(=O)[C@H1](CC(C)(C)C)OC)C1 CN1C(C(=O)NC[C@H1](CO)CNC(=O)CC=2C=CSC=2)=CC=3OC=CC=31 CCC1=NN=C([C@@H1](C)OC(=O)[C@@H1](C)N2C(=O)C3=CC=CC=C3C2=O)O1 CCC1=NOC=C1C(=O)N[C@H1]2C[C@H1](CCNC(=O)[C@]34C[C@H1]5C[C@@H1](C(=O)N3)[C@H1]4C5)C2 COC1=CC=C(Cl)C(C(=O)NCC23CC(NC(=O)COC4CC4)(C2)[C@H1](C)OC3)=N1 CCCN(CCNC(=O)[C@H1](C)OC1=CC=C(Cl)C=C1)C(=O)C2=CC=C(CO)C=N2 C[C@@H1](CC(=O)N1CCO[C@@]2(CCCN(C(=O)C3=CC=NC(F)=C3)C2)C1)C4CC4 C#CC1(C(=O)N(C)C[C@@H1](OC)C(C)C)CN(C(=O)[C@H1]2OCCO[C@H1]2C)C1 COC1=CC=NC(C(=O)NC[C@@H1]2CN(C(=O)CC=3C=CN(C)N=3)[C@H1]4CCN2C4)=C1 CN(C)C1CCC(C(=O)NCC2(F)CC(NC(=O)C34CCC(F)(CC3)C4)C2)CC1 C#C[C@H1](CNC(=O)[C@H1]1CC(=O)CN1C(=O)[C@@H1](C)CCN(C)C)CC(C)(C)C C[C@H1](NC(=O)C1=CN=C(O)O1)C2(O)CN(C(=O)CC3=CC=C4SC=CC4=C3)C2 COC1=NC(N2CC(CN(C)CC3=CC=C(Br)C=N3)C2)=NC=4[NH1]C=NC1=4 O=C(CC1=CC=CC(Br)=C1F)NC[C@@H1]2CN(C(=O)CSC(F)F)CCO2 COC1=CC=C(C(=O)N[C@@H1]2C[C@@H1]2NC(=O)[C@@]3(C)CCCS3)C=C1[N+1](=O)[O-1] CC1=CC=C(CC(=O)N[C@@H1]2CCC[C@@H1]2C(=O)N[C@@H1](COC(C)C)C(=O)O)C=C1 O=C(C[C@H1]1CCOC1)NCC2(NC(=O)C=3C=CC(=O)N4C=3COCC4)CC2 CN(C(=O)CCCCC1=CC=C(Cl)C=C1)C2C[C@@H1]3CC[C@H1](C2)N3C(=O)[C@@H1]4C[C@H1]4F C[C@]1(NC(=O)[C@@H1](O)C2CC2)CCCN(C(=O)C3=C(C(F)F)N=C4C=CC=CN34)C1 CN(C)C(=O)C1=CC=CC=C1C(=O)NC[C@H1](NC(=O)C2=CC(=O)N(C)O2)C3CC3 C[C@@H1]1C[C@H1]2CN(C(=O)COCC3CCOCC3)C[C@H1]2N1C(=O)C4=CC=NC=N4 CC1=CC(CC(=O)N[C@@H1]2CCOC[C@@H1]2NC(=O)C3=CN4C(=N3)CCCC4)=N[NH1]1 COCC[C@@H1](CNC(=O)[C@@H1](F)OC)NC(=O)C=1C=C2N=CC=CN2N=1 CCCC[C@H1](CC1=CC=CC=C1)N[C@@H1](CC2)C[C@@H1]3CC[C@H1](C2)N3 COCCOCCC(=O)NCCO[C@@H1]1CCN(C(=O)[C@H1](C)C2=CC=C(Cl)C=C2)C1 CO[C@@H1]1CC[C@H1]1C(=O)NCCCCCCN(C)C(=O)[C@H1](O)C2CCCCCCC2 COC1=NC=CC(C(=O)NCC=2C=C3N(N=2)CCN(C(=O)[C@@]4(C)C[C@@H1]4F)C3)=N1 CC1=C(C2=CN3C=C(C(=O)NC[C@H1]4CCC(F)(F)C4)C=CC3=N2)C=NN1C C[C@@H1](O)C(=O)N[C@@H1]1CN(C(=O)C2=CC=C(C3CCCCC3)N=C2O)CC1(F)F CC=C[C@@H1](O)C(=O)N1CCN(C2CCN(C(=O)C3=CSC=C3C4CC4)CC2)CC1 CC1=CC(C)=C(CC(=O)NC[C@H1]2[C@@H1]3CN(CC4=CC=CC(F)=C4F)C[C@H1]23)C(O)=N1 C#CCN(CC(=O)NC[C@H1](O)C(N)=O)C(=O)C1=CC=C(Cl)C=N1 COC1=NC=CN=C1C(=O)N2CC[C@H1](OCC(=O)N[C@@]3(CO)CCCC[C@@H1]3C)C2 CC1(C)COC[C@@H1]1CC(=O)N2C[C@H1](CNC(=O)C3=C(Cl)CC3)[C@](F)(CO)C2 CCCCCC1=CC=C(N[C@H1]CCC[C@H1]2CCCN2)C=C1 CC[C@@](C)(O)C(=O)N[C@@H1]1CC[C@H1]1NC(=O)CC2=CC=C(C(C)=O)C=C2 COC[C@@H1]1CN(C(=O)CC2=CN=CC=N2)CCN1C(=O)COC3=CC=CC(F)=C3 CC1=CC=C2C=NC(C(=O)NC(C)(C)[C@H1](C)NC(=O)C3=CN=CC=N3)=CC2=C1 CCN(CC(N)=O)C(=O)C[C@H1](C)CNC(=O)CNC1=CC=CN=C1 COC1=CN2C(=CC1=O)CN(C(=O)C3=CC=CC(OCC4=CC=CC(C)=C4)=C3)CC2 CC=1ON=C(O)C=1C(=O)NC[C@H1]2C[C@H1](CNC(=O)COCCN(C)C)CO2 CC1=CC=C(C(=O)N[C@@H1](C)CCN(C)C(=O)[C@H1](CCCO)C2=CC=CC=C2)S1 CCC1=C(C(=O)N[C@@H1](C)C(=O)N2CC(SCC)C2)CCCO1 CC(C)[C@@H1](C)[C@@H1](CNC(=O)COCCN(C)C)NC(=O)C1(C)CCSCC1 CO[C@@H1](C)C1=NC(C(=O)N(C)C2CC(NC(=O)C3=CC=NN3CC#N)C2)=CS1 O=C(C1CCC(NCC2=CN=CC(O)=C2)CC1)N[C@@H1]3COCC4=CC=CC=C43 CC1=CC(C(=O)N[C@H1](C)C[C@H1](C)NC(=O)C[C@H1](C)C(F)F)=CS1 C[C@@](O)(CN=C1C=C(Br)C=C(C#N)[NH1]1)C2CCC2 CC1=NOC(C(=O)N[C@H1]2C[C@H1]2CNC(=O)C3=CN=NS3)=C1C CC1=CC=CC(C(=O)N[C@H1](C(=O)NCCCOCC2CCC2)C3(C)CC3)=C1C#N CC[C@@H1](C)CCCCC(=O)N(C)C[C@@H1](C)NC(=O)C1=CC2=CN=CC(C)=C2S1 CCN(C(=O)COCC1CCOCC1)[C@@H1]2CCCN(C(=O)[C@@H1](C)CC(F)(F)F)C2 C#CCSCC(=O)N1CCN(C(=O)C2CC(C(F)(F)F)C2)CC[C@@H1]1C CCC1=NOC(CCCC(=O)N2C[C@H1](NC(=O)C3(CC#N)COC3)C[C@H1]2C)=N1 COC(=O)CCS(=O)(=O)N[C@@H1]1CCCC12CN(C(=O)C=3C=CN(C)C=3C)C2 COC1=CC(Br)=CC(CN=C(NC2CCC2)N3CCS[C@H1](COC)CC3)=C1 C[C@@H1]1OCC[C@@H1]1C(=O)N[C@H1](C)C[C@@H1](C)NC(=O)[C@H1]2CCC3=CC=NN3C2 O=C(N[C@H1]1CC[C@H1](NC(=O)C2CC2)CC1)C3=CC4=CC=CC(Br)=C4C=N3 O=CNCC(=O)NC[C@@H1]1CN(C(=O)CC23CCCN2CCC3)[C@H1]4C[C@@H1]41 CCCC[C@@H1](O)CNC(=O)[C@@H1]1CC12CC(NC(=O)C=3SC(F)=CC=3C)C2 C=CCCCC[C@@H1](C)NC(=O)C(=O)N[C@@H1]1CCO[C@@H1](CC)C1 CC1=CC(C(=O)N[C@@H1]2CC[C@@H1](CCNC(=O)COC3CCC3)C2)=CS1 CO[C@@H1](CNC(=O)COCC1=NN=C(C)S1)CNC(=O)[C@@H1]2CCCC(=O)N2C CC1=CC=C(C)C(C(=O)N2CCN(C)[C@@H1](CNC(=O)[C@@H1](O)C(C)(C)C)C2)=C1 COC=CC1=CC(CN2CC3(CC(C(=O)N4CC[C@@H1]4CO)[C@@H1]3C(=O)NCCC#N)C2)=C1 C[C@@H1](CS(C)(=O)=O)C(=O)N1CC=C[C@@H1](NC(=O)C2=C[NH1]C3=C(F)C=CC=C23)C1 CCC[C@@H1]1CCC[C@H1]1C(=O)NCC2(NC3=NC=NC(=N)[NH1]3)CCOCC2 CC(C)[C@H1](C)C(=O)N[C@H1]1CN(C(=O)C2=CS(=O)(=O)CCC2)C[C@H1]1C COCC1=CC=CC=C1CC(=O)NCC[C@@]23CC[C@@H1]2CN(C(=O)/C=C/C(C)C)C3 COCC1(N[C@@H1](CCC2CCC(F)(F)CC2)C3=NN=NN3C4CC4)CCC1 CCC[C@@H1](CCCNC(=O)C1=CC=CC2=CC=NN12)N=C3[NH1]N=C(C4CC4)S3 O=C(N[C@H1]1CCC1=O)C2=CN=CC(C=3C=COC=3)=N2 O=C(NC[C@@H1]1CCCN1C(=O)CC2CC(F)C2)C3=CC=C(C4=CC=CN=C4)S3 CCOC1(C(=O)NCCCN2CCN(C(=O)C3=NC=C(Cl)C=C3F)CC2)CCC1 C=CCC1(C(=O)N[C@H1](C)CC2CCN(C(=O)C=3N=NSC=3C)CC2)CCCC1 CSC(C)(C)C(=O)N1C[C@@H1](C)[C@@H1](NC(=O)C=2C=CC3=C[NH1]N=C3N=2)C1 COC(=O)[C@H1](NC(=O)[C@H1](F)C1(O)CN(C(=O)[C@@]23CSC[C@@H1]2C3)C1)C4CCC4 C[C@H1]1CCCN(C(=O)C(=O)N2CCC[C@@H1]2CCNC(=O)[C@@H1]3CCCO3)C1 CCC[C@H1](O)C(=O)N1C[C@H1]2C[C@@]2(CNC(=O)C3=C[NH1]N=C3S(N)(=O)=O)C1 CCC[C@H1](C#N)C(=O)NCC1=N[NH1]C=C1C(=O)N2CC[C@H1]2C COCC(=O)N1CC[C@@H1](C(=O)N(C)[C@@H1](C)CN(C)C)[C@H1](C)C1 CC=1C=CN(C)C=1C(=O)N2CCOC[C@H1](C(=O)N3CC(C)(CCO)C3)C2 CC(C)(C)OC(=O)N1[C@H1](C(=O)N[C@H1]2CCC[C@H1](CN)C2)C[C@H1]3COC[C@H1]31 CCC[C@H1](O)C(=O)NC[C@@H1]1CCN(C(=O)CCOCC(F)(F)F)C[C@@H1]1C2CC2 CN(C(=O)C=1C=CON=1)[C@H1]2CCC[C@H1](NC(=O)CCOCC(C)(C)C)C2 CC=1SC=CC=1C(=O)NC[C@@H1](C)CNC(=O)C2=CC=C(NS(C)(=O)=O)C=C2Cl COC(C)(C)[C@H1]1CCN(S(=O)(=O)C2=C(Cl)N=C3C=C(Cl)C=CN23)C1 CCCCSCC(=O)NC[C@]1(C(F)F)CCN(C(=O)C(C)(C)C2=CC=CN=C2)C1 COC(C)(C)[C@H1](C)NC(=O)NCC1(C)CCC2(CC1)OCCO2 C=CCCC1(C(=O)N(C)CCCN(C)C(=O)C=2C(C(F)F)=NN(C)C=2C)CC1 CC[C@@H1](OC1=CC=CC=C1)C(=O)NC[C@]2(F)C[C@H1](CNC(=O)[C@H1](O)CC)C2 O=C([C@H1]1CCC2(CCOCC2)C1)N3CCC[C@]4(CCCO4)C3 CC1=CC=C(CNC(=O)C/C=C/CNC(=O)[C@@H1]2C[C@@]2(F)Cl)C(C)=C1 CCC1=CC=C(C(=O)NCC[C@H1]2COCCN2C(=O)C=3C=CC4=CC=NN4C=3)S1 COC1=CC=CC=2SC(C(=O)NC/C=C/CNC(=O)[C@@H1]3CC[C@H1]4C[C@H1]4CC3)=CC1=2 COCC1=C(Cl)C=CC=C1NC(=O)[C@@H1]2CCOC3=CC=C(Br)C=C32 C[C@H1](CNC(=O)COCC1=NC=CN1C)NC(=O)[C@H1]2CCOC3=CC=C(F)C=C32 CC1=CC=C([N+1](=O)[O-1])C(C(=O)N2CCSC[C@@H1]2C(=O)N3CC[C@H1](CO)[C@H1](F)C3)=C1 C[C@@H1](CN(C)C(=O)C(O)(C1CC1)C2CC2)NC(=O)C=3SC=CC=3S(=O)(=O)N(C)C CC1CC(CCC(=O)N(C)C[C@H1](O)CNC(=O)C2=CC3=C(S2)CC(C)(C)C3)C1 C=CCCC(=O)N1CCC[C@@]1(CNC(=O)C=CN2C[C@@H1](C)C[C@H1]3C[C@@H1]32)COC CSC1=CC(C(=O)NCCOC(C)(C)CNC(=O)C2=CCOCC2)=CC=C1F O=C(NCC[C@H1]1CCN(C(=O)[C@@H1]2CC3=CC=CC=C3S2)C1)C4=CC=CC(=S)N4O C#CC1=CC=CC(C(=O)N2CCN(C(=O)[C@H1](OC)C3CC3)C[C@H1]2C)=C1C CN1C=NC=C(C(=O)NC[C@H1](O)C(=O)NC2(C)CC(F)C2)C1=O CCN(C1=NN=C(C2=CN=C3N2CCOC3)N1CC4=CC=CS4)C(C)C COC1=CC=C2C(=C1)N([C@H1](C(=O)NC[C@@H1]3CCCO3)[C@H1]4CCOC(C)(C)C4)CC2 CCC[C@]1(NC(=O)[C@H1]2C[C@@H1]2[N+1](=O)[O-1])CCCN(C(=O)CCN(C)CC)C1 CN1CC2(C1)CN(C(=O)[C@H1](F)CC3CN(C(=O)C45CCC(CO)(CC4)C5)C3)C2 CCCN(CCC=1N=C[NH1]N=1)[C@@H1](C(=O)NC(C)C)C2=CC(Cl)=C(Cl)N2C CC1=CC(C#N)=CC(C(=O)N2CC[C@H1](O)[C@@H1]2C(=O)N3CC(=O)N4CCC[C@H1]4C3)=C1 CO[C@@H1](C)C(=O)N1C[C@@H1]2C[C@H1](NC(=O)C3[C@H1](C)[C@H1]3C)C[C@@H1](C2)C1 CC1=NOC(Cl)=C1CC(=O)N[C@@H1]2CCCC[C@@H1]2NC(=O)CNC(=O)CC(F)(F)F CCN(CCCNC(=O)C=1SC=CC=1C(C)C)C(=O)[C@H1]2OCCN(C)C2=O CC[C@@H1]1C[C@H1](C(=O)N2CC[C@@H1]3C[C@]32C(=O)NC/C=C/Br)CCO1 COC1=CC=C(CNC(=O)C2=CC=C3C(=C2)[C@H1](C)CO3)N=C1C(F)(F)F CC1(N)CCC(NC(=O)NC2=CC=C(OC3CCCOC3)C=C2)CC1 C[C@@H1]1C[C@@H1](CNC(=O)C[C@@H1]2CC3=CC=CC=C3C2(C)C)CN1C(=O)C4=COC=N4 CC[C@H1](O)[C@@H1](C)C(=O)N1CCC[C@H1](N2C=C(CNC(=O)C3(C#N)CC3)N=N2)C1 CCC=1C=C(C)[NH1]C(=NC[C@]2(C)CCN(C(=O)[C@@H1]3C(F)(F)C34CCC4)C2)N=1 CSC1=CC=C([C@@H1](C(=O)NC2CC2)N3CCOC[C@@H1]3C4CCOCC4)O1 CN1C=C(SCC(=O)NCCCNC(=O)[C@@H1]2CCC(C)(C)C2)C=N1 C[C@H1](O)[C@H1](C)CNC(=O)C1=CN=CC(CNC(=O)[C@@H1]2OCCCC2(C)C)=C1 C=CCC[C@H1](NC(=O)C[C@H1]1CSCCO1)C(=O)N[C@@H1](C)COC(F)(F)F CC1=CN=C(CN[C@H1](C2=NN=NN2C3CCOCC3)[C@]4(C)CCCO4)C=N1 CC1(C(=O)N2C[C@@H1](NC(=O)CCCC3CCCC3)C[C@]24CCOC4)CSC1 COCC1=NOC=C1C(=O)N2CC(CNC(=O)[C@@H1](OC)C3CCCCC3)C2 C=C(C)CCCC(=O)NC[C@]1(C)CCN(C(=O)C2=CC3=C(Cl)N=CC=C3O2)C1 CCN(C)CCC(=O)N[C@H1]1CCC[C@H1](N(C)C(=O)C2=CC=CN=C2)C1 O=C(C1=CC=C(O)C(I)=C1)N2CC[C@]3(CC(C(=O)N4CCCC4)=NO3)C2 COCCN(CCCN(C)C)C[C@H1]1CCN(C)C2=CC=CC=C21 C[C@@H1](NC(=O)C1CC(=O)C1)[C@@H1]2CN(C(=O)C34CCCN3CCC4)CCO2 COC1=CC(CN[C@@H1]2C[C@@H1]2C(=O)NCC3=CC=CC(Br)=C3F)=CC(OC)=C1OC C=C(Cl)C[C@H1](NC(=O)[C@H1]1CCN(C)[C@@H1]1CC)C(=O)N2C[C@@H1](CO)C[C@@H1](C)C2 C=CC[C@H1](CNC(=O)[C@@H1](C)C#N)NC(=O)C1=C(Cl)C=CC(Br)=C1Cl CC(=O)NC1=CC(F)=CC=C1C(=O)N[C@@H1]2C[C@H1]2CNC(=O)C3(C)CC4(CC4)C3 CC=1N=C(S)SC=1CC(=O)N2CCN(C(=O)C=CC(=O)N(C)C)[C@@H1](C)C2 C[C@@H1]1CC[C@H1](NC(=O)CC(=O)NC2CC2)CN1C(=O)C3=CN4C(=N3)CCCC4 C1=CN=NC(NC2C[C@H1]3CC[C@H1](C2)C3)=C1 CC[C@@H1](C(=O)N[C@@H1]1C[C@H1]2[C@@H1](C1)[C@@H1]2NC(=O)C3=CC(C)=C(O)C(C)=C3)C(C)C C[C@H1](NC(=O)[C@@H1](C)C(=O)OC(C)(C)C)C1CCN(C(=O)CNC(N)=O)CC1 CCC1=NC=CC=C1C(=O)N[C@@H1](C)[C@H1](C)NC(=O)C=C(C)C(C)C O=C(CCC1=NC(O)=N[NH1]1)N[C@@H1]2C[C@H1]3CC[C@H1]2N(C(=O)C=4C=NN5C=4OCC5)C3 C=CCN1C=CC=C1C(=O)N[C@H1](C)CCN(C)C(=O)C2=CC(O)=NN2C CN(CC(=O)N1CCC2(CC(NC(=O)[C@H1](F)C3CCC3)C2)C1)S(C)(=O)=O CCOC(=O)CN1N=CC=C1C(=O)NC[C@@H1](C)N(C)C(=O)[C@H1]2CCCN2N=O CC[C@@H1](O)C(=O)NC[C@]1(F)C[C@H1](NC(=O)[C@@H1](C)S(=O)(=O)CCC)C1 C[C@@H1](O)C1=CC=CC(NC(=O)[C@@H1]2C[C@H1](O)CN2C(=O)C=3SC=CC=3I)=C1 CCC1=NC(C)=C(C(=O)N[C@H1]2C[C@@H1](C)CN(C(=O)C3=CC(O)=NC(O)=N3)C2)S1 O=C(N[C@@H1]1C[C@@H1]2CN(C(=O)C3=CC=NS3)C[C@@H1]21)C4=CC(Br)=N[NH1]4 COC1=CC=2N=C(C3=CC=NN3C)[NH1]C(=NC[C@]4(C)CCC[C@H1]4C)C=2C=C1OC NC1=CN=CC(C(=O)N[C@H1]2CCC[C@@H1]2CNC(=O)C3(O)CCC3)=N1 CC[C@@H1]1CN(C(=O)[C@@]2(C)CCN(C(=O)C3=CC(F)=CC(F)=C3)C2)CCO1 COC1=CC=CC=C1OCC(=O)N[C@H1]2CCN(C(=O)COCC(F)F)C[C@H1]2F CCOC[C@@H1](N=[N+1]=[N-1])C(=O)N[C@H1](CO)C(=O)NCC1=CC(C)=C(C)N=N1 CC1=CC=NC(C(F)(F)C(=O)NC[C@@H1]2CN(C(=O)[C@H1]3CCCOCC3)CCCO2)=C1 C[C@H1]1CN(C(=O)C2=C[NH1]N=C2C(F)F)C[C@H1]1NC(=O)C=3N=COC=3[C@@H1]4CCCO4 CC1=NC=CC(C(=O)N[C@H1]2C[C@]3(C(=O)NCCNC(N)=O)CO[C@H1]23)=C1C O=C(NC[C@@]12C[C@@H1](CO1)N(C(=O)CC3=CC=NS3)C2)C=4C=C([C@@H1]5CCOC5)[NH1]N=4 CNC1=CN=CC(C(=O)N2CCN(C(=O)C3(CCF)CCC3)C[C@@H1]2COC)=N1 C#CCNC(=O)CC(=O)NC1CC([C@@H1](F)C(=O)NOCCCC)C1 C#CC[C@@H1](C)C(=O)N[C@]12CCC[C@@]1(F)CN(C(=O)C3=CN=NS3)C2 COC1=CC=CC(OC)=C1CCN[C@@H1](C[C@@H1]2CCCO2)C3=NN=NN3C4CCC4 CCC1=CN=C(C(=O)NC[C@@H1]2CC[C@@H1]3CN(C(=O)[C@@H1]4C[C@H1]4C)C[C@@H1]32)C=N1 O=C(CC1=CN=CN1C2CC2)N[C@@H1]3CCCN(C(=O)C=4C=C5N(C=4)CCC5)C3 C#CCC(C)(C)C(=O)N[C@@H1](C)C[C@@H1](C)NC(=O)C1=CC=NC=C1OC(C)C COCC=CC(=O)NC[C@@]1(F)CCCN(C(=O)[C@]2(OC)CCSC2)CC1 COCC1(C(=O)N2[C@H1]3CC[C@@H1]2C[C@@H1](N(C)C(=O)C45CCC(CC4)C5)C3)CCC1 COC1=CC(Br)=CC(N2CCN(C(=O)C(=O)NC[C@H1](O)CC(C)C)CC2)=C1 CC[C@H1]1CCN(C(=O)C[C@@H1]2CCCSC2)[C@@H1](C(=O)N3CC(=O)NC[C@@H1]3C)C1 CC(C)(C)C(=O)N1C[C@H1](C#N)[C@H1](NC(=O)CSC2=NC=CC=N2)C1 C[C@@H1](CCNC(=O)[C@@H1]1CCCN1N=O)NC(=O)/C=C/C2=C(Cl)N=C3SC=CN23 CN(C[C@@H1]1CCCN(C(=O)CN2CCCC2)C1)C(=O)C3=CSC=C3C(F)F CCCN1C=C(C(=O)NCC=2C=CSC=2C(=O)NCC(C)(C)C(F)F)C=N1 CCN1N=C(C(=O)N2C[C@H1]3C[C@H1](NC(=O)C4=CC(SC)=C(C)O4)C[C@H1]3C2)C=C1C CC=1[NH1]C(=N)C=CC=1C2=NC(C3=CC=C(N4C=CN=C4)C=C3)=NN2C COCCCCCC(=O)N1CCC(F)(CNC(=O)CN2CCC(O)CC2)CC1 CN1N=NN=C1SCC(=O)N2CCN(C(=O)C=3[NH1]C4=CC=CC=C4C=3Cl)[C@H1]5C[C@H1]52 CCCS(=O)(=O)N[C@@H1](C)C(=O)NCC1(CNC(=O)COC[C@H1]2CCCO2)CCC1 C=C1C2=CC=CC=C2C(=O)N1CC(=O)NC[C@@H1](O)CN(C)C(=O)C3=CCCS3 CCN(CC1=CC=C(F)C=C1)[C@@H1](C(=O)NC(C)(C)CC)C=2C=C(C(N)=O)ON=2 NS(=O)(=O)C1=CC=C(C(=O)NC[C@@H1]2CCCCCN2C(=O)[C@H1](O)C3CCC3)C=C1 CC1=NC(C(=O)NC[C@@H1]2C[C@@H1](CNC(=O)C=CCN3C=NC=N3)CO2)=CO1 COC1=CN=NC=C1C(=O)NCC2[C@@H1]3CN(C(=O)C4=COC5=CC=CC=C45)C[C@@H1]23 CN=C1[NH1]C(=NCC2=CC(Br)=CN2C)[NH1]C(=NCC=3C=NC4=CC=NN4C=3)[NH1]1 CC1=C[C@@H1](C(=O)N[C@H1]2COC[C@H1]2NC(=O)C3=CC=C4N=C(O)OC4=C3)SC1 C[C@H1](O)[C@H1](O)CNC(=O)C[C@@H1](NC(=O)[C@@H1](O)CN1C=NC=N1)C(F)F CCOC=1SC=CC=1C(=O)NC/C=C/CNC(=O)C2=CN=CC(C(C)=O)=C2 CC1=CC(C(=O)N[C@H1]2CC[C@H1]2CNC(=O)[C@H1]3CC[C@@](C)(O)CC3)=C(C)C=C1Cl CCN1CCC[C@H1]1CNC(=NCC#C[C@@H1]2CCCCO2)NCC3=CN=C(Br)S3 CCC(F)(F)CC(=O)N1CCC[C@@H1](N(C)C(=O)[C@H1](O)C(C)(C)CC)CC1 CO[C@H1]1CCOC[C@H1]1NC(=O)C[C@@H1]2CCN(CC3=CC(F)=CC(F)=C3)C2 C=CC=CCC(=O)N(C)CC(C)(C)NC(=O)CC[C@H1]1CC2=CC=CC=C2NC1=O C[C@H1](C(=O)N(C)CCC1CCN(C(=O)[C@@]2(C)CC(C3CC3)=NO2)CC1)N(C)C CC1=CC=CN=C1CCC(=O)N[C@H1](CNC(=O)[C@]2(C)C[C@@H1]2Br)C(C)C CC1=CC=C(NC(=O)C(=O)NC2CC(Cl)(Cl)C2)C(I)=C1 C[C@@H1](CCC(=O)OCC1=CC=C(CCC(=O)OC(C)(C)C)C=C1Br)C2=CC=CC=C2 CN1C(=O)OC[C@@H1]1C(=O)N2CC[C@H1](C(=O)N3CC(F)(F)C(F)(F)C3)C24CC4 CC(=O)N1CCN(C(=O)CNC(=O)[C@@H1]2CCN2C)CC13CCC3 CN1N=CC(NC(=O)C2=NC=CC=C2NC(=O)C3(C4=CN=CC=N4)CC3)=C1C#N CCC[C@]1(NC(=O)C[C@H1](CC)C2CCC2)CCCN(C(=O)C34CC5C[C@H1]3[C@H1]4C5)C1 C[C@@H1](CCNC(=O)C1=CC=C(NC=O)C=C1)N(C)C(=O)CC2(N3CCCC3)CC2 COC1=CC=C2C(=C1)CCN(C(=O)CN3C(=O)N[C@]4(CCCC(C4)C)C3=O)[C@@H1]2C CN1C(C(=O)NC2CC3(C2)C[C@H1]3NC(=O)C4=CC=C(O)C(Br)=C4)=CN=C1O C[C@@H1](CC1=CC=CC=N1)NC(=O)CC(C)(C)N(C)C(=O)C2(CCCF)CC2 C[C@H1]1C[C@@H1]1C(=O)NC[C@H1](C)CN(C)C(=O)CC2=CC=C(O)C([N+1](=O)[O-1])=C2 CO[C@@H1](F)C(=O)N(C)[C@H1]1CCCN(C(=O)C2=CC=C(N)C(Cl)=C2O)CC1 COCC1CC(NC(=O)[C@@H1](NC(=O)[C@H1](CSC)OC)C2(O)CCCCC2)C1 CO[C@@H1]1CN(C(=O)[C@H1]2C[C@@H1]3CC[C@H1](C2)C3=O)C[C@@H1]1NC(=O)C=4C=C[NH1]C(=N)C=4 CCN(C[C@H1](C)O)C(=O)[C@@H1]1CN(C(=O)C23CCC(C2)C3)CC(C)(C)C1 CCOC(=O)C1=CC=C(S(=O)(=O)CF)C=C1NC(=O)[C@@H1]2CCCN(C(=O)NC)C2 CC1(C#CC(=O)N[C@@H1]2CCC[C@@H1]2NC(=O)C3=CC4=CC=C(F)C=C4O3)CC1 CC(=O)N[C@H1]1CCN(C(=NCCCF)NC[C@@H1]2CCCS(=O)(=O)C2)C1 CC1(C)CC[C@@H1]1CC(=O)N2C[C@H1]3[C@@H1](C2)OCCN3C(=O)C4CC5(CC5)C4 CCC[C@@](C)(O)C(=O)N1CCC[C@](O)(CNC(=O)C=CC2=CN=CN=C2O)C1 COC(=O)C[C@H1](C)C(=O)N[C@]1(C)C[C@@H1](NC(=O)C2=CC=C(C(F)(F)CF)C=C2)C1 C#CCOC1=NC=CC=C1C(=O)NC[C@@](C)(NC(=O)C=CC2=COC=N2)C3CC3 C=CC[C@]1(NC(=O)[C@@H1](C)N2CCSCC2)CCN(C(=O)CSC3=CC=NC=C3)C1 COC[C@H1](O)C(=O)NC[C@@]1(C)CC(F)(F)CN1C(=O)C=2C=CC(=N)[NH1]C=2 CC(C)[C@H1](C(=O)N[C@H1]1CN(C(=O)C2=CC(N)=NC(Cl)=C2)CC3(CC3)C1)C4CCC4 CC[S@@](=O)CC(=O)NCCOCCCNC(=O)[C@@H1]1CC=C(C)C[C@@H1]1C CN(C)C(C)(C)CCC(=O)N1CC2CC(C(=O)NCC3=CC=CC=C3F)(C2)C1 C=C[C@@H1]1COCCN1C(=O)C2(CNC(=O)C=CCO)CCC2 CON1CCC(C(=O)N[C@@](C)(CO)CNC(=O)C(F)(F)C2=CC=CC(Cl)=C2)CC1 CC(=O)N[C@H1](C)C(=O)N1CC[C@](C)(C(=O)N2C[C@H1](O)C[C@@H1](O)C2)C1 CC1(C)[C@H1](CNC(=O)/C(Cl)=C/Cl)CCN1C(=O)C2=CC(Cl)=C(F)C=C2F CCC1=CC=C(C(=O)N[C@H1]2CCC[C@H1](N(C)C(=O)C3=CN(C)C(C)=N3)C2)O1 CCC[C@](C)(O)CC(=O)N[C@H1]1CCN(C(=O)C2SCCCS2)[C@H1](C)C1 C=CC[C@@]1(C(=O)NCCCC(N)=O)CCN(C(=O)[C@@H1](C)C2=CN=CN=C2)C1 CC1=CC=CC(C)=C1OC[C@@H1](C)NC(=O)[C@@H1]2[C@H1]3CN(C4=CC=NC(C#N)=N4)C[C@H1]32 CSC1=NC=CN=C1C(=O)N(C)[C@H1](C)CNC(=O)[C@@H1]2CCC3=NN=C(O)C=C3C2 C[C@@H1](NC(=O)[C@@]1(O)CCSC1)C2CCN(C3=NC=CC=N3)CC2 CC(C)(O)C1CC(NC(=O)C2(CNC(=O)[C@H1]3C[C@@]3(F)Cl)CCC24CCC4)C1 CCC[C@@H1]1CN(C(=O)[C@H1](C#N)C(C)C)CCN1C(=O)C=2C=CC3=C[NH1]N=C3C=2F CC=1N=CSC=1CC(=O)N2C[C@H1](C)[C@@H1](C(=O)NCC3=CC(O)=CC(F)=C3)C2 O=C([C@@H1]1CCC2(CC2)N1C(=O)C34CCC(CO)(CC3)C4)N5CCC[C@@H1](CCF)C5 CN1C=NC=C1CC(=O)NCC[C@@H1]2CC[C@@H1](NC(=O)C3=NNC(=O)C3)C2 COCCCNC(=O)[C@H1](C1=CC=CC2=CC=NC=C12)N(C)[C@H1](C)CN(C)C(C)=O CSC(SC)C(=O)N1CC[C@@H1](C2CCN(C(=O)[C@@H1]3CCSC3)CC2)C1 CS[C@H1]1C[C@H1](CC(=O)N2C[C@@H1](C(=O)N3CCCC[C@@H1]3CC(C)C)CC2(C)C)C1 C=CCC[C@@H1](NC(=O)CCCOCC)C(=O)N(C)C1CCCCCCC1 C#CCCC[C@H1](C)C(=O)N1C[C@H1]2CC[C@@]2(C(=O)N[C@H1]3CC[C@@H1]3C(=O)OC)C1 CCO[C@@H1](C(=O)N1CC(CC(C)(C)CNC(=O)C2=CC(Cl)=CS2)C1)C3CC3 CC1=CN=C([C@@H1](NC(=O)C2CC3(C2)CC3(F)F)C4CC4)S1 O=C(C=CC1=NC2=CC=CC=C2[NH1]1)NCCCNC(=O)C3(CC(F)(F)F)CC3 COCCC(=O)N[C@@H1]1CCN(C(=O)C=C(C)C2=CC=CO2)C[C@@H1]1C3=CC=CC=C3 CC(C)CCCCCC(=O)NC[C@H1]1C[C@@H1]1NC(=O)C2=CC=C3C(=C2F)CCC3 COCCNC(=O)[C@H1]1CN(C(=O)[C@@]2(C#N)CCCOC2)CC13CC3 C[C@H1]1CC[C@@H1](NC(=O)C2=C(F)C=CC(N)=C2F)CN1CC3=CC=CC=C3 C=CCO[C@H1](C)C(=O)N[C@@H1]1C[C@H1]2C[C@@H1](C1)N(C(=O)COCCC(C)C)C2 CC=1SC(Cl)=NC=1C(=O)N[C@H1]2CCCN(C(=O)[C@@H1]3CC4(F)CC3C4)[C@H1]2C COC1(CC(=O)NC2CN(C(=O)[C@@](C)(O)C3=CC=CC=C3)C2)CCCCC1 CO[C@@H1](CCS(C)(=O)=O)C(=O)N1CCN(C(=O)[C@H1](O)CC2=CC=CC=C2)CC1 CCN1C=C([C@H1](C(=O)O)N(C)CC2=CC=C(OCC#N)C=C2)C=N1 CC=1N=C(CC(C)C)SC=1C(=O)N(C)C[C@H1](C)NC(=O)C2(C)C(C)(C)C2(C)C CO[C@H1]1CC[C@H1](C)N(C(=O)CN(C(=O)C2=C(C)OCCC2)C(C)C)C1 C[C@@H1](CC(=O)NCCO[C@H1]1CCN(C(=O)C2=CC(O)=NO2)C1)NC3=NC=CS3 CC1=NC=C2N1CCN(C3=CC=NC(N4CCCC5(CCOCC5)C4)=N3)C2 CCCN1C=CC(C(=O)N2CCCCN(C(=O)C[C@@H1]3CCO[C@@H1]3C)CCC2)=N1 CC1=NC=C(C)C(=NC[C@H1](O)CNC(=O)C2=CSC(C=3C=N[NH1]C=3)=N2)[NH1]1 O=C(COC1=CC=CC=C1)NCCNC(=O)[C@H1]2C[C@H1](O)C2 N#CC1=CC2=C(N=C1NC3CN(C(=O)C4=CC=C(F)C5=CC=NC=C45)C3)CCOC2 CC=CC=CC(=O)NC12CCC(CC1)N(C(=O)CN3CCOCC3)C2 COCC1(NC(=O)[C@H1](C)N(C)C)CCN(C(=O)[C@@H1]2CC(=O)[C@H1]2C(C)(C)C)CC1 CCCC1=NC(C)=C(C(=O)N[C@@H1](CC)CNC(=O)C2=CC=NC=3[NH1]C(O)=NC2=3)S1 COCCN(CCNC(=O)C1=NC=CC2=C(Cl)C=CC=C12)C(=O)C3=CN=C(O)O3 CC1=CNC(C(=O)NC2CC(F)(CNC(=O)C3COC3)C2)=C1 COC1=NC(Cl)=CC=C1C(=O)N[C@@H1]2CN(C(=O)C3=CCCCO3)C[C@H1]2S(C)(=O)=O CN1N=CC(C(=O)N2CCC([C@]3(O)C[C@@H1](NC(=O)C4=CC=NN=C4)C3)CC2)=C1N CCC1=CC=C(C(=O)N[C@H1](C)C[C@H1](C)NC(=O)[C@H1]2CCCN2CC)[NH1]1 CC(=O)NCCNC(=O)C(=O)N1CC(CO)(NC(=O)C[C@@H1]2C=CCC2)C1 O=C(NCCCN1CCOCC1)[C@@H1]2COCCN2C(=O)C3=CC([N+1](=O)[O-1])=CS3 CSC[C@@H1](O)C(=O)N1CCN(C(=O)C2=CC=C(N(C)C)N=C2)C[C@H1]1CF CN(CC(=O)NCC[C@@H1]1CN(C(=O)[C@@H1](O)CC(N)=O)CCCO1)C2CCC2 COC(=O)COCC(=O)N[C@H1](C)[C@@H1]1C[C@H1]1C(=O)N(CC(C)(C)CO)C2CC2 O=C1C[C@@H1](C(=O)N[C@@H1]2C[C@@H1]2NC(=O)/C=C/C3=CN=C[NH1]3)CN1C4CC4 CC1=NC(SCCC(=O)N(C)CCOCCNC(=O)C[C@@H1]2CCCOC2)=N[NH1]1 CCOC[C@H1](CO)NC(=O)[C@@H1](CC=1C=C[NH1]N=1)NC(=O)C2=CC=C(C#N)O2 CCNC(=O)C(=O)N[C@@H1](C)[C@@H1](CO)NC(=O)C1=CC2=C(O1)CCCC2 CCN(CCNC(=O)[C@@H1]1CSCN1C(C)=O)C(=O)/C=C/C=2SC(Cl)=NC=2Cl CC1=NC(C(=O)N[C@@H1](C)C2(O)CN(C(=O)C=3C=C4N(N=3)CCC4)C2)=N[NH1]1 CC=1C=C(C)N2C=CC(C(=O)NCCN(CCNC(=O)[C@@H1](C)CF)C3CC3)=C2N=1 CCC(C)(C)NC(=O)[C@H1]([C@H1]1C[C@@H1]2C[C@@H1]2C1)N3C[C@H1](C)CC[C@@H1]3C O=C(CC1(NCC2=CC=C(OC(F)(F)F)C=C2Cl)CCC1)NCC3=CC(Br)=NO3 COCCNC(=NCCC1=C(C)CCCC1(C)C)NC[C@H1]2CCCO[C@H1]2C(C)C CC1=CC=C(CSCC(=O)N2CC[C@H1](C3(NC(=O)[C@@H1]4CC4(F)F)CC3)C2)C=C1C CNC(=O)CCC(=O)N(CC1CC1)C2CCN(C(=O)CN3CCCCC3)CC2 CC[C@H1](C)OC1=CC(C)=CC=C1CN[C@@]2(C(=O)OC)CCC3=CC=CC=C32 CC[C@@]1(C(=O)N2CCC(CNC(=O)C34CC(C(F)F)(CO3)C4)(COC)CC2)CC1 CC1=NN=C(CN2CCC([C@@H1](C)NC(=O)[C@H1](C)NC(=O)C3=CC=CS3)CC2)S1 C[C@@H1](CC(=O)N1CCOC[C@H1](NC(=O)C2=CN=NC(O)=C2)C1)CC(F)(F)F CCCO[C@H1]1CCCN(C(=O)[C@@H1](CCF)NC(=O)CC2CCC(=O)CC2)C1 C=C(CCNC(=O)COCCC1=CC=CC=C1)CNC(=O)C(C)(C)CSC C[C@H1](O)C(F)(F)C(=O)N[C@H1]1CCCC[C@H1]1NC(=O)[C@@H1](O)CC2=CC=C(F)C=C2 C=C=C[C@H1](C)C(=O)N[C@@H1]1C[C@@H1]1CNC(=O)C2=CN=C3N=CC=NC3=C2 COC(=O)CC(=O)N1C[C@H1](NC(=O)C2=C(Cl)CCOC2)[C@H1]3CCC[C@@H1]31 COC1=CC=C(Cl)C=C1C(=O)N2CCN(CC3=CC(Cl)=NC=C3Cl)[C@@H1](C(C)C)C2 C=C[C@]1(C(=O)N2CCC(COC)CC2)CCN(C(=O)C3=CN=NC(C)=C3)C1 COC1=CC(C(=O)NCCNC(=O)CN2CCC=3SC=CC=3C2)=CC=N1 CC1=NO[C@H1](CC(=O)NC2(CN(C)C(=O)C3=CC=C(F)C(CN(C)C)=C3)CC2)C1 CN1N=C[C@H1](CC(=O)NC2(CC(N)=O)CCN(C(=O)CC3=CN=CS3)CC2)C1=O C[C@@H1]1C[C@@H1]1C(=O)N(C)CC2CN(C(=O)C3=CC([N+1](=O)[O-1])=C[NH1]3)C2 CNS(=O)(=O)C=1C=C(C(=O)N[C@H1]2CCN(C(=O)C3=CN=C(O)N3C)C2)N(C)C=1 COC(=CC1=CC=CC=C1)C(=O)N[C@H1]2C[C@@H1](NC(=O)[C@@H1]3CCCC4=CN=CN43)C2 CS(=O)(=O)C=CC(=O)N[C@H1]1C[C@H1](CNC(=O)C2=CC=CC3=CC=NC=C23)C1 CN(C)C1(C(N)=O)CN(C(=O)[C@@H1](NC(=O)C2=C[C@H1]3C=C[C@@H1](C2)C3)C4CCCC4)C1 C[C@@H1](C(=O)N1CC[C@@H1](C)N(C2=CC(C3CC3)=NC=N2)CC1)S(C)(=O)=O CC=1C=CN([C@H1](C)CC(=O)N[C@H1]2C[C@@](C)(NC(=O)CN3C=NC(=N)[NH1]3)C2)N=1 C#CCCCCCNC(=O)C1=COC(CNC(=O)C2=CC=CC=C2Cl)=C1 CC[C@@H1]1CC[C@H1](C(=O)N2CCC3(CCC3)[C@@H1](CNC(=O)C(C)C)C2)O1 CC(C)(O)CC(=O)N1CCN(C(=O)C2=CC=CC3=C2SCCC3)[C@@H1]4C[C@H1]41 CC1=NN(C)C=2SC(C(=O)NC3(CNC(=O)C4=CC=C(Cl)C=C4O)CC3)=CC1=2 COC1=CC=C(S(N)(=O)=O)C=C1C(=O)N(C)[C@H1]2CC[C@@H1](NC(=O)CCC3CC3)C2 CCC[C@]1(NC(=O)C2=CC=NS2)CCCN(C(=O)[C@@H1]3CCCN4CCCC[C@H1]34)C1 NC1=CC=C(C(=O)N[C@@H1]2CCCCN(C(=O)C3=CC(F)=C(F)C(F)=C3)C2)N=C1N O=[N+1]([O-1])C1=CC=CC(C2=NOC(CN3CCC[C@H1](N4CCNCC4)CC3)=N2)=C1 C#CC[C@](C)(NC(=O)C=1C=C2C=CC=CN2C=1)C(=O)NC[C@]3(C)CC3(C)C CCCN1N=CC=C1C(=O)N2CCCC[C@@H1](CNC(=O)C3=C(C)N=CN=C3C)C2 COCCOCC(=O)N[C@H1]1CCCN(C(=O)[C@@H1]2C[C@H1]2C3=CC=C(C)O3)CC1 CC1=C(C(=O)N2CC[C@H1](C(=O)N[C@H1](C)C3CCN(C)CC3)C2)C=CN1C CN(C(=O)C1=NC(=O)N(C)[NH1]1)[C@@H1]2CC[C@H1](NC(=O)CSC3=NN=NN3C4CC4)C2 CCCNC(=O)CCC(=O)NCCCN(C(=O)[C@H1]1CCS(=O)(=O)[C@@H1](C)C1)C(C)C CC=CC[C@@H1]1CCCN([C@@H1](C(=O)NCC2=CC=CO2)C3=NC=CC(Cl)=C3Cl)C1 CNC=1SC=NC=1C(=O)N2CCOC[C@H1](C(=O)N3CCN(C)C[C@@H1](O)C3)C2 COC(=O)[C@H1]C[C@@H1]N[C@H1](C1=C(F)C=CC(C)=C1Cl)C2=NN=NN2CCCC3CC3 CC1=CC=C(Cl)C=C1OCC(=O)NC[C@H1]2CCN(C(=O)C34CC(C)(C3)C4)C[C@H1]2C COC(=O)C1=CC(NC(=O)C2=CC(C3=CN=C(SC)N=C3)=CC=N2)=CN1C C[C@@H1]1[C@@H1](NC(=O)[C@H1](C)NC(=O)CC(C)(C)C)CCN1C(=O)C[C@H1]2CCOC2=O CO[C@H1](C)C1=NC(C(=O)N2CC(CNC(=O)C3=C(C)OCC3)(OC)C2)=CO1 CO[C@@H1]1C[C@H1]1C(=O)N2CC[C@@H1]3CCN(C(=O)C(C)(C)CN4CCOCC4)C[C@@H1]32 CCCC(=O)N1CC=C[C@H1]1C(=O)N(C)CCCC(F)(F)F CC=1SN=CC=1C(=O)N(C)[C@H1]2C[C@@H1](NC(=O)C[C@@H1]3COC(=O)C3)C2 C=CC[C@H1](CNC(=O)[C@](C)(O)C1=CC=CC=C1)NC(=O)C2=CSC(CO)=N2 CCC1=C(C(=O)N(C)CCCCN(C)C(=O)C=2C=CSC=2C)C=NN1C C[C@H1]1CN(C(=O)CCCNC(=O)C2CC2)CCN(C(=O)C[C@@H1]3COC[C@H1]3O)C1 CC1(C(=O)NCCC2(CNC(=O)C3=CC(F)=CC=C3O)CC2)CCCCC1 CCC1=CC(C(=O)N2CC[C@@H1](NC(=O)CCC(C)(C)F)[C@H1](C)C2)=CC=N1 CN(CC(=O)N[C@H1]1C[C@H1](NCC2=CC=C(F)C=C2Br)C1)C(=O)C3=CC=CC=C3 C=CCC1(C(=O)N[C@H1]2CC[C@H1]2CNC(=O)[C@H1]3CC4=CC=C(C)C=C4S3)CC=CC1 CC[C@H1](C)CCC(=O)N(CCNC(=O)C1=CC=C(C(F)F)C(C)=C1)C(C)C CO[C@@H1](CSC)C(=O)N1CC2(CCN(C(=O)[C@H1](C)N3CCNC3=O)CC2)C1 COC1=NC=CC(C(=O)N2CCCC[C@H1]2C(C)(C)CNC(=O)CCCCCF)=N1 C=CCNC(=O)[C@H1](CCC1=CC=C(Br)C=C1)N2C[C@H1](OC)CC[C@@H1]2C O=C(CCC(F)(F)CN1C=C(C2CCC2)N=N1)N3CCOC[C@@H1]3C4=NC=CC=N4 CN(C[C@]1(O)CCN(C(=O)C2CC(=O)NC(=O)C2)C1)C(=O)[C@@H1]3CNC(=O)C3 C[C@H1](CN(C)C1=NC(=N)[NH1]C(=NCCCC2=CC(O)=N[NH1]2)[NH1]1)C3=NC=CS3 CCOCCCN=C(NCC(C1CCC1)C2CCC2)NC3CCN(CCOC)CC3 C[C@@H1]1CC[C@@H1](C2=CC=CC=C2)N(C(=O)NC3(C4=CC=CC=C4)CC3)C1 C=C1CC[C@@H1]1C(=O)NCC(C)(C)NC(=O)C[C@@H1]2C(=O)N(C)N=C2C CN1CC(C)(C)C[C@H1]1C(=O)NCCN(C(=O)CCOC2=CC=C(Cl)C=C2)C3CC3 O=C(CCC1=CC=CC(Cl)=C1Cl)N[C@H1]2C[C@@H1](CNC(=O)C3=C[NH1]C(C(F)F)=C3)C2 C[C@@H1](CF)C(=O)N1CC[C@@H1](N(CCO)C(=O)/C=C/C2=CN=CC(O)=C2)C1 C/C=C/C[C@@H1](C)C(=O)N1CCC[C@H1]1[C@H1](C)NC(=O)C2=CC=C3C=CN(C)C3=C2 CC1=C(C)CN(C2=NC(NCC3=CN(C)[NH1]C3=N)=C4N=CSC4=N2)C1 CC1=CSC(CC(=O)N[C@@H1]2CC[C@H1]2NC(=O)C3(N4CCOCC4)CCC3)=C1 CCCN(CCNC(=O)[C@@H1]1CCN1CC)C(=O)C=2C=C(C)N(C(C)(C)C)N=2 CCN(CC1CCN(C(=O)C2=CC=C3N=N[NH1]C3=N2)CC1)C(=O)C4=CCCCC4 CCC=1OC=CC=1C(=O)N2CCN(C(=O)C[C@@H1](C)C(F)F)[C@H1](COC)C2 COC1=CC=CC=2C=C(CN(C)CCNC3CC3)[NH1]C1=2 CN(C(=O)C1(CNC(=O)C[C@@H1]2CCCSC2)CCCCC1)[C@H1]3CCC[C@@H1]3C#N CC(C)C1=CC=C(C(=O)N[C@](C)(CNC(=O)C=CC2=CN(C)N=N2)C3CCC3)O1 CCC[C@H1](C)N(C)CCC(=O)NC[C@]1(NC(=O)[C@H1]2CC[C@H1](CC)CC2)CCOC1 CC(C)CCCOCC(=O)NC(C)(C)C[C@H1](F)C(=O)N1O[C@H1]2CC[C@H1]1C2 CCCCCCCCC1CCN(C(=O)C=2C=CN(C(C)C)N=2)CC1 COCC(C)(C)CC(=O)NCC1=CC=C(CCNC(=O)[C@@H1]2SCC[C@H1]2C)C=C1 CCCNC(=O)CCN=C(NCC1CCCCC1)N2C[C@H1](OC)[C@H1](OC)C2 O=C(N[C@]12CC[C@H1]1CN(C(=O)C3=CN=CC=N3)C2)C4=CSC(N5CCCCC5)=N4 C=C1CC(C)(C(=O)N[C@H1](CCOC)CNC(=O)[C@@H1](F)N2C=CN=C2)C1 CC=1SC(C)=C(C(=O)NCC[C@@H1](NC(=O)[C@@H1]2CCC[C@H1](C)C2)C(C)C)C=1C#N CCN(CCNC(=O)CC1(OC)CC1)C(=O)C2=CC(Cl)=NC(N3CCOCC3)=C2 CN1CCC[C@@H1]1CCC(=O)NC[C@@H1]2CC3(CC3)CN2C(=O)CN4N=CC=N4 O=C(CO)N[C@@H1]1CCN(C(=O)C2=N[NH1]C3=C(F)C=CC=C23)CC14CCC4 C=C(C)COCC(=O)NC[C@@H1](NC(=O)C1=CSC(CCCC)=N1)C2CCCCC2 O=C(COC1CCC1)N[C@]23CCC[C@@]2(F)CN(C(=O)[C@H1]4C[C@H1]4C(=O)NCCO)C3 COCC[C@@H1](CNC(=O)C1=CC(Cl)=NC=C1OC)NC(=O)C(C)=C(C)C CCN1C=NC(C(=O)N2CC(SC(F)F)(C3CC3)C2)=C1 C[C@H1](CC1=CC=CC=N1)C(=O)N2CCC3(CCN(C(=O)C4=N[NH1]C=C4Cl)CC3)C2 O=[S@]1CC[C@H1](NCC=2C=C(C(F)F)ON=2)C1 C#CC[C@H1](CCOC)NC(=O)C(C)(C)CNC(=O)CC1(O)CCCC1 CC[C@H1](C)C(=O)N[C@H1]1C[C@@H1](NC(=O)C(C)(C)CN(C)C)C1 CSC1=CSC=C1C(=O)NCC2(CN(C)C(=O)C3=CC=NC=4[NH1]N=CC3=4)CC2 CC(=O)N[C@H1](C(=O)NC[C@@H1](C)NC(=O)C=1C=C2C(Cl)=CC=CN2N=1)C(C)C CC=CC=CC[C@H1](O)C(=O)NC1C[C@@H1](C)NC(=O)CCC1C2=CC=C(C)C=C2 CC(C)N(CCN(C)C(=O)C1=CC=NC(O)=C1)C(=O)[C@@H1]2CCN(C3CC3)C2=O CCC(CC)(CNC(=O)[C@]1(OC)CCOC1)C(=O)N[C@@H1](C)C(F)F CCNC(=O)CCC(=O)N1[C@H1]2CC[C@H1]1CC(C(=O)NC=3C=CC(=O)N(CC)C=3)C2 CCC1=CN=C(CNS(=O)(=O)C2=CC=CC(=NCC3=C(Cl)C=NN3C)[NH1]2)O1 CN1C=NN=C1CCC(=O)N2CC[C@H1]([C@H1]3CCCN(C(=O)C=C(Cl)Cl)C3)C2 CC1=CC(C)=C(C(=O)N[C@@H1](C)[C@@H1](NC(=O)C=C2CCCC2)C3=CC=CC=C3)S1 CC1=CN=C(C(=O)N2CCN(C(=O)C3=CON=C3C)C[C@@H1]2CC4CC4)N=C1 CCC[C@H1](CC)[C@H1](C(=O)NCSC1=CC=CC=C1)N2CC[C@@](O)(C(=O)OC)C2 O=C(NC[C@]1CC2C[C@@H1]1N(C(=O)C3=CC(Br)=N[NH1]3)CCCO2)C4=CC=[N+1]([O-1])C=C4 COC[C@H1](C)N1C[C@@H1]2[C@H1](C1)[C@@H1]2NC(=O)C3=CC=CC=C3C(=O)C4=CC=C(Br)C=N4 COC1=NC=C(C(=O)N2CC[C@]3(NC(=O)[C@H1](C)C4CC4)CCCC[C@@H1]23)C=N1 CC/C=C/CC(=O)N[C@H1]1CCOC[C@H1]1NC(=O)C2=CC=CC(NS(N)(=O)=O)=N2 C#CCC[C@H1](NC(=O)C1=N[NH1]C=C1C#C)C(=O)NCCCC=2C=N[NH1]C=2 CCC1=CC=CC=C1CC(=O)N[C@@H1]2CN(C(=O)CC3=CC=CC(C)=C3Cl)[C@@H1]4C[C@H1]24 CC1=CC(F)=CC(C(=O)NCC2CCN(C(=O)[C@@H1]3CCCCN3N=O)CC2)=C1C CC(C)(C)[C@@H1]1CC(C(=O)NCC2(F)CN(C(=O)[C@H1]3CC34CC(O)C4)C2)=NO1 CC(C)C=1C=NN(C)C=1C(=O)NC[C@@H1](C)NC(=O)C2CN(S(=O)(=O)C(F)F)C2 COC1=CC=C(F)C=C1C(=O)CN2C=NC3=C(Cl)C(C)=CC=C3C2=O C[C@@H1]1CN(C(=O)[C@H1](O)CC(C)(C)C)CCCN1C(=O)C=2C=NN(C)C=2C(F)(F)F CCOC1=CC=C(C(=O)NCC(=O)NC[C@@H1](CO)CNC(=O)[C@H1]2CC[C@H1]2C)C=C1 CO[C@H1]1C[C@@H1](C(=O)NC2=CC=NC(Cl)=C2C)N(CC3=CC(O)=CC(Cl)=C3)C1 C[C@@H1]1CC=CC[C@@H1]1CNC2=CC=C(F)C(N3C=CC=C3)=C2 CNC=1SC=NC=1C(=O)N2CCC([C@@H1](C)C(=O)NC[C@H1]3CC(C)(C)CO3)CC2 C=CCCCC(=O)N1CC([C@H1]2CCCCN(C(=O)C=3SC(=NCC)[NH1]C=3C)C2)C1 C#CCCN(CC)C(=O)[C@H1]1CCCCC[C@H1]1NC(=O)C2=CC(O)=CC(=O)O2 CC=1C=CN2C=NC(C(=O)NCCC[C@@H1](C)NC(=O)C[C@H1]3CCOC3)=C2C=1 COC1=CC(C)=C2C(C(=O)N=C3C=NC=C(OC(C)C)[NH1]3)=COC2=C1 CC=CC(=O)N[C@H1]1CC[C@@H1](NC(=O)[C@@H1](CC)CC2CCCCC2)C1 C#C[C@@H1](CC(C)(C)C)NC(=O)[C@H1]1C2=C[NH1]N=C2CN1C(=O)C3=CC=C(N)C=N3 CC1=C(N)C=CC=C1C(=O)N[C@H1]2[C@H1]3C[C@H1](CN(C(=O)[C@@H1]4CC[C@@H1]5C[C@@H1]54)C3)[C@H1]2CO CC1=CN=CC=C1CNC(=O)[C@H1]2CC[C@H1](C)CN2C(=O)CC(C)(F)F C=CCCC(=O)N1CCC[C@@]1(C)C(=O)NC[C@H1](OC)C(C)C COC1(C(=O)N2C[C@H1]3CCC[C@@](NC(=O)[C@@H1]4C[C@H1]4C5CCC5)(C3)C2)CCOCC1 COCC(COC)NC(=O)[C@H1]1C[C@H1]1NCC=2SC=CC=2C CC=CC(=O)N(CCCNC(=O)C1=N[NH1]C2=C1CC[C@H1]2C)CC3=CC=CN=C3 CCC(CC)(CNC(=O)[C@@]12C[C@@H1](O)[C@@H1]1C2)NC(=O)CCCCN3C(=O)CCC3=O C[C@@H1]1[C@H1](C(=O)NC[C@]2(CO)CCCN(C(=O)[C@@H1]3CCCN4C=CN=C43)C2)[C@@H1]1C O=C(CC1=CC=C2N=CSC2=C1)N[C@H1]3C[C@@H1](CCNC(=O)[C@@]4(F)CC=CCC4)C3 C[C@@H1](CN1CC[C@H1](CC(=O)O)C1)CC2=CC=CC=C2 CC[C@]1(C)C[C@H1](NC(=O)C=2N=C(O)SC=2C)CN1C(=O)C3CCCC3 O=C(C[C@@H1]1CC2=CC=CC=C2CN1)NC3=C(F)C=CC=C3OC4=CC=CC=C4Cl CN(CC1=CN(C)N=N1)C(=O)[C@H1]2CCCC[C@H1]2NC(=O)C(C)([C@H1]3)CCOC3 CNC(=O)C[C@@H1](C)NC(=O)CC1=CC=CC(CC(F)(F)F)=C1 CSC1CCN(C(=O)[C@H1](F)[C@@H1]2CCN(C(=O)CCC3(C)CC3)C2)CC1 CC(=O)C(=O)N1CCO[C@@]2(CCCN(C(=O)[C@@]34CC[C@@H1](C3)OC4)C2)C1 CN1C=NC(CCC(=O)NC2(CNC(=O)COC=3C=N[NH1]C=3)CCCCC2)=C1 CSCCC(=O)NCCOCCN(C)C(=O)C1=C(C(C)=O)[NH1]C2=CC=C(F)C=C12 O=C(NC1=CC=C(CO)N=C1)[C@@H1]2CCN(CC3=CC=CC4=NC=CC=C34)C[C@H1]2O O=C([C@H1]1CCCC=2SC=CC=21)N(CC3=CC=CC=C3)[C@@H1]4CCS(=O)(=O)C4 COC1=CC=C(Br)C(C(=O)N[C@H1](C)C2CN(C(=O)[C@H1]3CSCCS3)C2)=C1C COC1(CC(=O)N2C[C@@H1](O)[C@H1](CNC(=O)CCOC3CC3)C2)CCOCC1 O=C(N[C@H1]1C[C@@H1](O)CN(C(=O)C2=CC=C(CO)O2)C1)C=3C=C(C(F)F)[NH1]N=3 CC1=CC=CC(NC(=O)C2CN(C(=O)C3=CC=C(S(=O)(=O)F)C=C3)C2)=N1 C#CCN(CCC(=O)N1CCOC[C@H1](C2CC2)C1)C(=O)C=CC3=CC=NC=C3 COC1=CC=C(CC(=O)N[C@H1]2CN(C(=O)C(C)(C)SC)CC3=NC=CN3C2)N=C1 O=C(N[C@@H1]1CCN(C(=O)C2=CN=C(O)O2)C1)[C@@H1]3C[C@H1]4C=C[C@@H1]3C45CC5 COC(=O)C1=CC=C(CN=C2C=CC3=CC=CN=C3[NH1]2)C(C)=C1 CC(C)C1=NC=C(C(=O)N[C@H1]2C=CCC[C@H1]2C(=O)N3CCO[C@H1](CCO)C3)O1 O=C(N[C@H1](CO)CCO)C1=CC=C(C2=NOC(C3CC3)=N2)C=C1 CC(C)(C)CCC(=O)C(=O)N1CCC[C@@H1](NC(=O)CCC=2N=C[NH1]N=2)CC1 CC1=CC[C@@H1](C(=O)N(CCNC(=O)[C@@H1]2C[C@H1]2[N+1](=O)[O-1])C3CCCCCC3)CC1 COC[C@@H1](C)CC(=O)N(C)C1CCN(C(=O)CN2CCC(=O)CC2)CC1 C[C@@H1]1CCCN(C(=O)C2=CC=C(Cl)O2)[C@@H1]1CNC(=O)C[C@@H1]3C=CCC3 CC/C=C/CC(=O)N1C[C@@H1](C(=O)NC2=CC(N3CCCC3)=CC=N2)C[C@@H1](F)C1 C[C@H1](N=C1N=C2C(N=CN2C)=C(N[C@@H1](C)C3=CC=NS3)[NH1]1)C4=CC=C(Cl)C=C4Cl C[C@@H1](F)CC(=O)N[C@H1]1CCC[C@]1(C)CN(C)C(=O)C2=CC=CN=C2N(C)C CCC1=CC(Cl)=CC=C1C(=O)NCCOC(C)(C)CNC(=O)[C@H1]2CCCCN2C CS[C@H1](C)C(=O)N1CCC[C@H1]1C(C)(C)CNC(=O)C[C@H1]2NC(=O)NC2=O CCC[C@@H1]1C[C@H1]1C(=O)OCC(=O)N(C)CC2=CC(Br)=CC3=C2OCC3 COC1CC2(C1)CC3(CC(C(=O)N[C@H1](CO)C4CC4)C3)C2 CCN(CC)[C@H1](C)C(=O)N[C@H1]1CCCN(C(=O)C2=C(C)N=C(C3CC3)N=C2C)C1 CC1=NC=CC=C1CCC(=O)NC[C@]2(NC(=O)C(=O)N3CC[C@@H1](C)C3)CCOC2 C[C@H1](NC(=O)CCN1CCCC1=O)[C@H1](C)NC(=O)C2=CN3C=CC=CC3=N2 CN(CCN(C)C(=O)C1CC(=C2CCC2)C1)C(=O)CN3CCOCC3 CNS(=O)(=O)C1=CC=C(CC(=O)N2CCOC[C@H1]2CNC(=O)COCCF)S1 CCCCOC1=CC=C(CN[C@H1]2C[C@H1](C(=O)NC3=CC(F)=C(C)C=C3Br)C2)C=C1 C[C@@H1](CCCN1C(=O)C2=CC=CC=C2S1(=O)=O)NC(=O)C(C)(C)[C@H1](F)C(F)(F)F C#CC[C@H1]1CN(C(=O)C2=CC(=O)C3=CC=CC=C3[NH1]2)CCO1 CNC(=O)N[C@H1](C)C(=O)N1CC2(CCCN(C(=O)[C@@H1]3OCCOC34CCC4)C2)C1 CO[C@@H1](C)CC(=O)NC1CC(F)(CNC(=O)C2=CC(Br)=CN3C=CN=C23)C1 CCCNC(=O)CN(C)C(=O)[C@@H1]1CCC(C)(C)N(C(=O)CCCCCOC)C1 CN(CC1(NC(=O)C2=CSC3=C(F)C=C(F)C=C23)CC1)C(=O)[C@H1](O)CF O=C(NCC1=CC=C(C(=O)N[C@]23CCCC[C@@H1]2C3)N=C1)C4=CC=NN4C5CC5 CN(C)CC[C@H1](NC(=O)C(=O)C(C)(C)C)C(=O)N1CCC[C@@](C)(C#N)C1 CCN1N=NN=C1[C@H1](NCC=2N=COC=2C)C3=CC4=CC=C(Cl)C=C4OC3 C=C[C@@](C)(O)CC(=O)NC[C@H1](OC)C(=O)N1CC[C@@H1](C(=O)OC)O1 C[C@]12COC[C@H1]1CN(C3=NC(NCC4=CC(=O)C=C[NH1]4)=C5N=CSC5=N3)C2 CN(C)CC(C)(C)CC(=O)NC[C@H1]1CC[C@H1](NC(=O)[C@H1](O)C2=CN=CN2C)CC1 CC[C@H1](CC(=O)N[C@](C)(C(=O)N1CCO[C@](C)(C(C)C)C1)C2CCC2)CN(C)C COCCN1C([C@@H1]2CNC(=O)N2)=NN=C1N(CC(F)(F)F)C3(C)CCCCC3 CC[C@@H1](C)[C@@H1](OC)C(=O)N1C[C@@H1]2CC[C@H1](C1)N2C(=O)CCCCCOC C[C@@H1]1CCO[C@H1]1CC(=O)N2CC[C@H1](NC(=O)CC3=CSC(C4CC4)=N3)C(C)(C)C2 NC1=CC2=C(C=C1C(=O)N3CC4(CCCCN4C(=O)C5=COC=N5)C3)OCO2 C[C@@H1](CCCCNC(=O)CC1=CC(Cl)=CC=C1O)NC(=O)CCC=2C=C[NH1]N=2 C[C@@H1](CCCCNC(=O)C1=CC2=CC=CN=C2N=C1O)NC(=O)[C@@H1]3CCCOC3 CS[C@H1](C)CCC(=O)N[C@@H1]1CCN(C(=O)C2=C(C)C=CC=C2Cl)C[C@@H1]1F CC1=CC=NC(C(=O)N2CCC[C@@H1]2[C@@H1]3CCN(C(=O)CCC4=NN=C(C)O4)C3)=C1 COC(=O)C[C@H1](C)NC(=O)NC[C@H1](C1=CC=CC=C1)C2=CC=C(C)C=C2 CCCOCCC(=O)NC[C@@H1]1CCN(C(=O)CCC=2C=NN(C)C=2)C13CCC3 CCCC(CCC)CCCC(=O)N1C[C@@H1]2C[C@H1]1[C@H1](N(C)C(=O)C=3C=NN(C)C=3)C2 C#CC[C@H1](C(=O)N1CCC2(CN(C(=O)[C@@H1]3C=C[C@H1]3C=4C=CSC=4)C2)C1)C5CC5 CN1N=CC(C(=O)N[C@H1]2CCC[C@H1](C(=O)N3CCC4=CC(Br)=CC=C43)C2)=C1Cl CC(C)[C@H1](C)CC(=O)NC[C@H1]1[C@H1](C)CCCN1C(=O)CCC2=NC=C(F)C=N2 O=C(CCC(F)F)N1CC2(C1)CN(C(=O)[C@@]34CCCCC[C@H1]3OCC4)C2 CC(C)N1C[C@@H1](C(=O)NCCCN(C)C(=O)C2CC3(C2)CC(F)(F)C3)CCC1=O CC#CCCC(=O)N[C@@]12CCC[C@@H1]1N(C(=O)C3=NC(OC)=CC=C3F)CCC2 CC=1SC=CC=1C(=O)NC[C@@H1](O)C(=O)NC2CCC([C@@H1](C)O)CC2 CC=1N=CSC=1C(=O)N[C@@H1](CCF)C(=O)N[C@@H1]2CCCCNC2=O C=CCN(CCC(=O)N[C@H1]1CN(C)CC1(F)F)C(=O)[C@H1]2CCCS[C@@H1]2C CCCCSCC(=O)N1CC(O)(CNC(=O)C2=CC=CC(C)=C2N)C1 CCC1=NC=C2C(=N1)C[C@H1]3CC[C@H1]2N3C(=O)C4=CC(Cl)=CC(OC(F)(F)F)=C4 CCOC[C@H1](NC(=O)[C@@H1](CC(C)C)C(C)C)C(=O)N1CCC2(CC1)C[C@@H1]2C#N CC[C@@](CO)(OC)C(=O)NCC1=CC(C(=O)N2CCC(C3CCC3)CC2)=CC=N1 CO[C@@H1](C)C1=CN([C@@H1]2CON(C(=O)CNC(=O)C3=C(F)C=CC=C3F)C2)N=N1 O=C(NCC1(C(=O)NC2=CC=C(Br)C(F)=C2)CC1)C3=CC(Cl)=CC(C(F)(F)F)=C3 CC1=CC(C(=O)N[C@H1]2CCN(C(=O)C=3N=C(Cl)SC=3C)[C@@H1]2C)=NC(N(C)C)=N1 CCC[C@H1](NC(=O)[C@H1]1C[C@@H1](O)C1)C(=O)NC2=CC=C(C)C(Cl)=C2 CCCC[C@@](C)(F)C(=O)N1CC[C@@H1](C)[C@@H1](NC(=O)CCOCC(F)F)C1 COC(=O)C1=CCS[C@H1](CNC(=O)N(C)[C@@H1]2CCN(C)[C@H1](C)C2)C1 CC/C=C/CC(=O)N(C)[C@@H1](C)CN(C)C(=O)C1=C(C)C=C(C(=O)OC(C)(C)C)O1 CC1=CC[C@@](C)(C(=O)N2C[C@@H1](NC(=O)C=3C=CN4C=CC=C4C=3)C(C)(C)C2)CC1 CCCNC(=O)C[C@@H1]1C[C@@H1](C)N(C(=O)[C@@H1]2C(C)(C)C2(F)F)C1 CN1C=C([C@@H1](O)C(=O)N2CC[C@@](CF)(NC(=O)CSC=3C=NN(C)C=3)C2)C=N1 CCC[C@@H1](OC)C(=O)N[C@H1](CO)CNC(=O)CCCC#CC1=CC=CC=C1 CC=1[NH1]N=C(C(=O)N(C)CC(C)(C)CNC(=O)[C@](C)(C2=CC=CS2)N(C)C)C=1Cl C#CCOCCOCC(=O)N[C@H1](C)[C@H1]1CCCN(C(=O)C2=CN=C(O)S2)C1 CCN1N=NC=C1C(=O)N[C@H1]2CCC[C@H1]2N3CCN(C(=O)[C@@H1]4CCN(C)C4)CC3 C[C@@H1]1CN(C(=O)CN2CCNC2=O)CC[C@H1]1NC(=O)[C@H1](F)[C@H1]3CCOC3 O=C(C=CC1=CC=C(Cl)C=C1)N2CCC3(C2)CN(C(=O)C4=CC=NC=C4F)C3 C#CC(CC)(CC)NC(=O)[C@](C)(CC)CNC(=O)C1=CN(CC=C)N=N1 CCC1(C#CC(=O)N2CC3(C[C@H1](NC(=O)[C@@H1](O)C4CCC4)CO3)C2)CC1 C=C(C)CCCC(=O)NC1(CCO)CN(C(=O)[C@@H1](CC)CCC)C1 CC[C@@](C)(COC)C(=O)N(C)CCCNC(=O)CN1N=C(C(F)(F)F)C(Cl)=C1C C=CC=1C=NN(C)C=1C(=O)NC[C@@H1]2C[C@@H1]3CCCC[C@@H1]3N2C(=O)C4CC4 CCN1C=C(NC(=O)[C@H1](F)CC(C)(C)NC(=O)C2=CCCOC2)C=CC1=O CCN(CC)CCO[C@H1]1CCN(C(=O)C2=CC=C(OC)C(O)=C2)C1 C[C@@H1](CNC(=O)C=1C=CN(C)C=1C2CCC2)NC(=O)C3=CC4=CSC=C4S3 CCN1CC[C@@H1](C(=O)N(C)CC2CCN(C(=O)C3=CC=CC(=O)N3C)CC2)C1 CN1CCC[C@H1]1CCC(=O)NC2(C(=O)N[C@H1]3C[C@H1](CO)C3)CCOCC2 CO[C@@H1]1CCC12CC(C(=O)N3CC(O)(CNC(=O)C=4SC=C(C)C=4Cl)C3)C2 CC1=CC=C2OC(C(=O)NCCCN(C)C(=O)C(C)(C)[C@H1](C)O)=CC2=C1 CC1=C(C(=O)N2CC[C@H1](NC(=O)CN3CCNC(=O)C3)C[C@H1]2C)[NH1]C=CC1=O COC1=CC=CC=2C(C(=O)N[C@H1]3CN(C4CCN(C)CC4)CC[C@@H1]3C)=C(C)[NH1]C1=2 C=CCCC(C)(C)C(=O)N1CC[C@@](F)(C(=O)N2CC3(CO[C@H1](C)C3)C2)C1 C=C(C)C[C@@H1](NC(=O)[C@@H1]1C[C@H1](C)CCN1C(=O)CCC(C)=O)C(=O)OC CC1=CC(O)=NC=C1C(=O)N2C[C@@H1]3C[C@H1]2C[C@H1](NC(=O)[C@@H1](O)CC(C)(C)C)C3 CC1=CC=C(N2C=CC(CNC(=O)N3CC[C@@H1](C4=CC=CC=C4O)C3)=N2)C=C1C C[C@@H1](O)C(F)(F)C(=O)NC1=CC=CC(NC(=O)[C@H1]2CCOC(=O)N2)=C1 CN(C)C(=O)N1CC(C(=O)NCC[C@H1]2C[C@H1](NC(=O)C=CCO)C2)C1 CC[C@]1(C)C=C(C(=O)NCC2(CNC(=O)[C@@H1](F)C3CCC(=O)CC3)CCC2)C1 C[C@H1](O)C(=O)N1[C@H1]2CC[C@H1]1CC(N3CCN4C(=CC5=CC(Cl)=CC=C54)C3)C2 CCN(C)[C@H1](C)C(=O)N1CCC(C=2C=C(C3=CC=CN=C3Cl)[NH1]N=2)CC1 CN1C=CC(CC(=O)N2C[C@@H1](NC(=O)C3=NN=CS3)CC24CCCC4)=N1 CO[C@@](C)(C(=O)NC1CC2(CCC(NC(=O)C=CBr)CC2)C1)C3CC3 CCN(C(=O)C[C@@H1]1C=NN(C)C1=O)[C@H1](C)CNC(=O)C2(COC)CC=CC2 O=C1NC[C@@H1](C(=O)NC[C@@]23CCC[C@H1]2N(C4=NC5=CC=CC(F)=C5S4)CCC3)N1 CCC[C@@](C)(O)C(=O)N(C)C[C@H1]1CCCCN1C(=O)/C(F)=C/CCF O=C(CC(C1CCC1)C2CCC2)NCC3CC4(C3)CC(NC(=O)C5=CC=CN5)C4 CC1=CC(C(=O)N[C@H1]2C[C@H1]2CNC(=O)C3COC3)=CC(N4C=CC=N4)=NO1 C[C@H1](CC1=CC=NC=C1)NC(=O)CC[C@@H1]2CCN(C(=O)CCC(C)(C)F)C2 CC[C@H1](C)C(=O)N1CCC(N(CC2CC2)C(=O)C3=CN=C(Cl)S3)CC1 CC1=C(O)C=CC=C1C(=O)NCC(C)(C)C#CC(=O)N2CCC3(CC2)CN(C)C3 CCC(CC)(OC)C(=O)NC[C@@H1]1COCCN(C(=O)C2=CC=C(F)C=C2O)C1 C/C=C/C=C/C(=O)N[C@H1]1CCC[C@H1](NC(=O)C2=C[NH1]C=C2C)C1 C=C(CCNC(=O)C1=CC(Cl)=CC=C1N)CNC(=O)C2=CN=NC3=CC=CC=C23 C#CCC[C@@H1](O)C(=O)N1CC[C@@H1](NC(=O)C=2C=C(C)OC=2C(F)(F)F)C1 CC(=CC(=O)NCCCCN(C)C(=O)[C@H1]1CCC2=CC=CC(F)=C21)C=3C=CSC=3 O=C1NCC[C@H1]1C(=O)N2CCC=3SC(CNC(=O)C4=C(F)C=NC=C4Cl)=NC=3C2 CC[C@H1](SC1=CC=CC=C1)C(=O)N2CCC(COC(C)=O)CC2 COC1=CC=CC(CCC(=O)NCC[C@H1]2CCCN2C(=O)C3=CCOC3)=C1OC CCC1=CN=CC=C1C(=O)NC[C@H1](C)N2CCN(C(=O)CC(Cl)Cl)CC2 CC(C)(CCCC(=O)NCC1=NC=CN1C2CC2)NC(=O)CCOCC3CC3 O=C1N[C@@H1](C(=O)N2CCC[C@@H1]2CN(C(=O)C3=CC(=O)C(Br)=C[NH1]3)C4CC4)CO1 CCN(C(=O)[C@@H1]1C[C@@H1]2C[C@@H1]2N1C(=O)C3=C[NH1]C4=CC=CC=C34)C5CC5 CO[C@@H1]1CN(CC(=O)NC2=C(F)C=C(F)C(F)=C2F)CC[C@@H1]1C(=O)O COC(=O)[C@@H1](CCC(C)C)NC(=O)C1=CC=CN2C=NC=C12 CN(C)C(=O)C=CC(=O)N1CCN(C(=O)C2=CC(Cl)=NC=C2Cl)[C@@H1](CCO)C1 CSC1=CC(F)=CC=C1C(=O)N[C@@H1]2CC[C@@H1]2NC(=O)CN3N=CC=C3C CP(C)(=O)C=1C=NN(CC=2N=C(C3CC3)N(C=O)N=2)C=1 CP(C)(=O)CC(=O)N1CCN(C(=O)C2[C@H1]3CCCCCC[C@H1]23)CC4(CC4)C1 C=CCCC(=O)NC[C@H1]1CCC[C@@H1](CNC(=O)C2(C3=CC=C(Cl)C=C3)CC2)C1 O=C(N[C@@H1]1COCCN(C2=NC(C3CC3)=NS2)C1)C=4C=C5N(N=4)CCO5 CCN1C=C(NC(=O)[C@@H1]2CC[C@@H1](C3CC3)N2C(=O)C=4[NH1]C=CC=4C)C=N1 CSC1(C(=O)N[C@H1](CC(=O)N[C@@H1](C(N)=O)C2CCCC2)C3CC3)CCC1 CC(C)C=1N=NSC=1C(=O)N2CC3(CCN3C(=O)CNC(=O)C4=CC=CC=C4)C2 CC(C(=O)N[C@H1]1CCCC[C@H1]1CC(=O)N(C)C[C@@H1]2CCC(=O)N2)=C3CCC3 CN1C=C([C@@H1]2CN(C(=O)C3=CSC(O)=N3)C[C@H1]2NC(=O)C4(C(F)F)CCC4)C=N1 CN=C1[NH1]C=CC(C(=O)N[C@H1](CC2=CC=C(C)C=C2Cl)C(=O)O)=C1N CO[C@@H1](CC(C)(C)C)C(=O)N1CC[C@@](C)(CC(=O)NC2(C=3N=C[NH1]N=3)CCC2)C1 C[C@@H1]1C[C@@H1](C(=O)NOCC2=CC=CC=C2)CN(C(=O)C3=CC4=CC=CC=C4C3)C1 CCC[C@@H1](C(=O)N[C@H1]1C[C@H1](NC(=O)[C@H1](C)SC[C@@H1]2CCCO2)C1)C(C)C C[C@H1](CC(=O)N(C)[C@@H1]1CCCN(C(=O)C2=CN=C3N2CCC3)C1)C4=CC=CN=C4 CC(=O)NCC(C)(C)C(=O)N[C@H1]1CC[C@@](C)(CNC(=O)C2CN(C)C2)C1 CC[C@@H1](O)CC(=O)N1[C@H1]2C[C@@H1](C[C@@H1]2F)[C@H1]1C(=O)OC CC=1ON=C(C(=O)N[C@H1]2CN(C(=O)[C@@H1](C)C3=CC=CC=C3Cl)C(C)(C)C2)C=1C CC1=CC([C@H1](C(=O)NC2CCC2)N3CCN(C4CCOCC4)CC3)=CC(C)=C1Br C[C@H1](NC(=O)[C@H1]1CCN1C)[C@@H1](C)C(=O)N(C)C2CC2 CC1CC(N(C)C(=O)[C@@]2(C)CCN(C(=O)C3CCCCCC3)C2)C1 C=CCN(CCO)C(=O)CCN(C)C(=O)/C=C/C(C)(C)C CC(C)N1C(=O)CC[C@H1]1C(=O)N[C@H1]2CC[C@@H1](C)N(C(=O)CC3CCN(C)CC3)C2 CC1=CN=C(CCNC(=O)C[C@@H1]2CCCN2C(=O)C[C@H1](C)C(C)C)C=N1 CC[C@H1]1CO[C@H1](CC)CN1C(=O)COC2CN(C(=O)C3=CC=C4C=CC=NN34)C2 O=C(NCC1=CC=NC(C=2C=COC=2)=C1)[C@@H1]3CCCC[C@@H1]3C4CC4 CC(C)C[C@@H1](CNC(=O)C1=CC=C(Cl)N=C1)NC(=O)[C@]2(N(C)C)CCCSC2 O=C(OCC1=CC=CC=2C=COC1=2)C3=CC([N+1](=O)[O-1])=NC=C3Br FC1(F)CCN(C(=NC[C@H1]2CC=CCC2)NC[C@H1]3CCCO3)CC14CCC4 COC1=CC=C(C(=O)C(=O)N(C)C[C@H1](C)CNC(=O)C2(C)CC(C)C2)C=C1OC CC(C)[C@@H1](CNC(=O)C1=C[C@@]2(CCOC2)C1)NC(=O)CC3=CC(C(F)(F)F)=N[NH1]3 CCN(CC)CCC(=O)N[C@H1]1[C@@H1]2CN(C(=O)C=3C=COC=3C4CC4)C[C@@H1]21 C[C@@H1](CCN(C)C(=O)C=1C=NN(CCF)C=1)NC(=O)C23CC(F)(C2)C3 C#CCNC(=O)C1(NC(=O)CCNC(=O)[C@@H1]2CCCC[C@H1]2CC)CC1 CC=1N=C([C@@H1](NCCCCS(C)(=O)=O)C2=NN=NN2C3CC3)OC=1C N#C[C@@H1]1CCN(C(=O)C[C@@H1]2C[C@@H1](O)CN2C(=O)[C@@H1]3CC34CCCCC4)C1 CCCC1=CC(O)=NC(NNC(=O)[C@H1]2CC3=CC=CC(C)=C3O2)=N1 COC=C1C=C2N=C(CNC(=O)N(CC3=CC=CN=C3)[C@H1](CCO)C(F)F)SC2=C1 COC(=O)C=1C=COC=1CNC(=NCC2CC2)NCC3=N[NH1]C=C3Br CC(=O)N(C)[C@@H1](C)C(=O)N1C[C@H1](N=[N+1]=[N-1])[C@H1](NC(=O)C2=CN=C(Br)S2)C1 C=C(C)C[C@H1](NC(=O)CN1CCOC1=O)C(=O)NCCC2=CC=CC(F)=C2 CC1=C(Br)C=CC=C1[C@H1](C(=O)NC2CCCCC2)N(C)C[C@@H1]3CCCN(C)C3 O=C(C=CC1=CC=CC(F)=C1)NCCC2CCN(C(=O)C=C[C@@H1]3CCCO3)CC2 CC1=CC=C(CNC(=O)C=2C=C(CNC(=O)[C@@]3(C)CC3(C)C)[NH1]N=2)N=N1 CCC1=C(C)C=CC=C1[C@@H1](C(=O)NCCCF)N2CCC(O)(CC(C)C)CC2 C=C[C@](C)(CC)C(=O)NC1C[C@@H1]2CCC[C@H1](C1)N2C(=O)[C@@H1](CO)C3=CC=CC=C3 CCCC=C(CC)C(=O)N1C[C@@H1](N(C)C(=O)CSCC(C)C)C2(CC2)C1 CC1=CC=C(CNC(=O)NC2=CC(O)=C(Cl)C=N2)C3=CC=CC=C13 O=C(CC1CC(C2CC2)C1)NC3CCC(C(=O)NC4(C=5N=C[NH1]N=5)CC4)CC3 C=C=C[C@@H1](C)C(=O)N[C@@H1](C(=O)N1CCCCCC[C@H1]1C)C2(O)CCC2 CCCN1CCC[C@H1]1C(=O)N[C@@H1]2CCC23CCN(C(=O)CC4=C(C)N=CN=C4C)C3 COC1=NC=NC(C)=C1C(=O)NCC(C)(C)CNC(=O)[C@H1](C)OC2CCCC2 CC=1C=C(C(F)F)OC=1C(=O)N2C[C@@H1](O)[C@H1](N(C)C(=O)CC3=CC=CN=C3O)C2 C=CCCCCC(=O)N1C[C@H1](CNC(=O)C2=CC=NC(CC(C)C)=N2)CC1(C)C CC(C)(C)[C@H1](CNC(=O)C1=C[C@H1](O)CCC1)NC(=O)C=2N=NN3C=2CCCCC3 CN(CC1=NC(O)=C2SC=CC2=N1)C(=O)NCCN3C=NC=N3 CCSCCCNC(=O)[C@H1]([C@H1]1C[C@@H1]1C)N2CCOC(C)(C)CC2 C[C@@H1]1CN(CC=2C=CSC=2Cl)CC[C@@H1]1NC(=O)C3=C[C@H1]4CCCCCC[C@@H1]34 CN(C)C[C@@H1](CC(=O)N1CC(NC(=O)CC=2C=NN(C(C)(C)C)C=2)C1)C(F)(F)F CC=1N=CSC=1C=CC(=O)NCCCC[C@@H1](CO)NC(=O)C2=CC=C(O)N=N2 C=C1CC(C(=O)NC[C@H1]2CC[C@H1](CNC(=O)[C@@H1]3CCO[C@@H1]3CC)CC2)C1 CCCCSCC(=O)N1C[C@@H1]2CS(=O)(=O)C[C@@]2(NC(=O)C3CC4=CSC=C4C3)C1 C[C@@]1(C(=O)NCC[C@H1]2CN(C(=O)CCOC3CC3)CCS2(=O)=O)CCOC1 O=C(CC1=CC=CC(OC2=NC=NS2)=C1)NCC=3C=NN(C[C@@H1]4CCOC4)C=3 CNC(=O)COCC(=O)N[C@@H1](C)[C@@H1]1CCN(C(=O)COC2=CC=CC=C2O)C1 COC(=O)[C@H1]1CC2=CC(C)=CC=C2N1C(=O)C3=COC=C3Br CCOC[C@H1](NC(=O)CCCCC(C)=O)C(=O)N[C@@H1]1CCN(C)C[C@@H1]1C C#C[C@H1]1C[C@H1]1C(=O)N2CC=C[C@H1]2CNC(=O)CN3CCCC4(CC4)S3(=O)=O COC1=CC(C(=O)N2CC[C@H1](C)C[C@@H1]2CNC(=O)CNC(C)=O)=CC(F)=C1F CC(=CC1=CC=C(F)C=C1)C(=O)NC(C)(C)CCNC(=O)C[C@H1]2CCCO2 CCC1=CC=CC=C1N(C)C(=O)[C@@H1]2CC[C@H1]2NC(=O)C=3SC=CC=3Cl CCCCC[C@@H1](O)CC(=O)N1C[C@@H1]2CC[C@]2(NC(=O)C3=CC(OC)=CC=C3Cl)C1 CC(C)CN1CC(C(=O)N2CC[C@@H1](CNC(=O)[C@H1](C)C=3C=CSN=3)C2)C1 CCOC1=CC(Cl)=CC=C1C(=O)NCC[C@@H1](C)CCNC(=O)CCCS(C)(=O)=O CCN1CCC[C@H1]1CNC(=O)C#CC(C)(C)CNC(=O)C2=CC=C(NC)C=N2 C#CCCC(=O)N(CC)[C@@H1]1CCN(C(=O)C2=N[NH1]C3=C2CS(=O)(=O)CC3)C1 COCCOCC=CC(=O)NC(C)(C)[C@@H1]1CCCN1C(=O)CN=C2C=C[NH1]C=C2 CCC=1C=C(C(=O)N[C@@H1](CO)CNC(=O)C2=CN(C(C)(C)C)C=N2)SC=1C CCCCS(=O)(=O)N1CCC[C@H1](C(=O)NC[C@@H1]2CCN(C(=O)C3=CCC3)C2)C1 C=CCC1(CC(=O)N[C@@H1]2C[C@H1]3CC[C@@H1]2N3C(=O)C(F)(F)[C@H1](C)O)CCCC1 CC1=CC=C(C(=O)N[C@@H1](C)[C@@H1]2CCCN2C(=O)C3=CC=C(OC(F)F)C=C3)C=N1 CC(C)N1N=NN=C1[C@@H1](NCC2(CO)C[C@H1]3C[C@@H1]3C2)C4=CC=C(Br)C(F)=C4 CC1=CC=C(O)C=C1C(=O)N2CCC[C@@H1](N(C)C(=O)CC(C)(C)C3CC3)CC2 C[C@@H1](CN(C)C)C(=O)NC1(CNC(=O)C=2OC=NC=2C3CC3)CCCC1 COCC(=O)N[C@H1]1C[C@@H1](CNC(=O)C2=CC=C(Cl)C(I)=C2)C1 CC=1C=NSC=1[C@H1](N=C2C=CN(CC(C)C)[NH1]2)C3=NN=NN3[C@H1]4CCOC4 CC1=CC=CC(C(=O)C(=O)NCC[C@H1](CNC(=O)C(C)(C)C(C)C)[C@@H1](C)C)=C1 C[C@@H1]1CCC[C@@H1]1C(=O)N2[C@H1]3CC[C@H1]2CC(CNS(C)(=O)=O)C3 O=C(CCC1=CCCCC1)N[C@H1]2CCC[C@@H1](NC(=O)[C@H1]3COCCC3(F)F)C2 CC[C@@H1](CNC(=O)C=1C=C(Cl)N(C)N=1)NC(=O)C(C)(C)C2=NC=CO2 C[C@@H1](CN(C)C(=O)[C@H1](C)OC1COC1)NC(=O)C2(O)CCSCC2 C#C[C@H1](NC(=NCCC)NC[C@@H1]1CCCC2(CCC2)C1)C(C)(C)OC CC[C@@]1(C)NC(=O)N(CC(=O)N[C@H1](C)CNC(=O)C2=C(C)C=CC(Cl)=C2O)C1=O C[C@@H1](O)[C@@H1](C)C(=O)NC[C@]1(C)CCCN(C(=O)CN2CCCCC2)C1 CN1N=NN=C1SCCC(=O)N2CC[C@@H1](NC(=O)CCCC3=CN=N[NH1]3)[C@@H1](F)C2 O=C(CS[C@H1]1CCCCO1)N[C@@H1]2[C@H1]3C[C@@H1]2N(C(=O)C4(CO)CCOCC4)C3 CCCN1C=C(C(=O)N(CCO)CCCNC(=O)C2=CC=C(C)C(C)=C2O)C=N1 CC(C)SCC(=O)NC[C@H1]1CCN1C(=O)C[C@H1]OC2C=NC3=CC=CC=C32 CC[C@@H1]1C[C@@H1]1C(=O)N2CC[C@@H1](C)[C@@H1]2CNC(=O)CCC3=CC=CS3 CC[C@@H1]1CCN(C(=O)C2=CC=NC3=NC=NN23)[C@@H1]1CNC(=O)[C@@H1]4CCCCO4 CCC[C@@H1](C)N1C[C@H1](C(=O)NC[C@@H1](C)CNC(=O)CCC=2C=CN(C)C=2)CC1=O CC(C)C1=NN(C)C=C1C(=O)NCCN2CCN(C(=O)C3=CCCOCC3)CC2 O=C(NC[C@@H1]1OC[C@@H1]2CCN(C(=O)C[C@H1]3C=CCCC3)C[C@@H1]21)C4=COCCC4 C[C@@H1](NC(=O)[C@@H1]1CN(C(=O)C[C@@H1](O)CC(C)(C)C)CC12CC2)C3=N[NH1]C(CO)=N3 CC(=O)N[C@H1]1CCCN(C(=O)[C@@]2(C)CCN(C(=O)[C@@H1]3CCCN(C)C3)C2)C1 O=C(NC[C@H1]1CN(C(=O)[C@@H1]2[C@H1]3CC[C@@]2(C4=CC=CC=N4)C3)C[C@H1]1O)[C@@H1]5CCCS5 C#CCCCCCC(=O)N1CCCC2(CCN(C(=O)[C@H1]C[S@](C)(=O)=O)CC2)C1 CN1CCC(N(C)C(=O)CC2CCC(NC(=O)CCC3CC3)CC2)CC1 CN(C)S(=O)(=O)N(C)CC(=O)NC[C@@H1]1CCN1C(=O)C2CC(C)(C)C(C)(C)C2 CC(C)C1=NN=C(CN2CCO[C@](C)(CNC(=O)C3=CC=NC(C4CC4)=C3)C2)O1 C[C@H1]1CCN(C(=O)[C@H1](C)C2=CC=C(F)C=C2F)C[C@@H1]1NC(=O)C3=CC=CC(Cl)=C3 CCNC(=O)C(=O)N[C@@H1]1[C@H1]2CCN(C(=O)CC=3SC(C)=NC=3C)C[C@H1]21 C=CCCC(C)(C)C(=O)N[C@@H1](C)CCCNC(=O)[C@]1(F)CC=CCC1 CCC1=NOC(COCC(=O)N[C@@]23CCC[C@H1]2N(C(=O)[C@]4(C)C[C@H1]4C)CC3)=N1 C=C1CC(CC(=O)NC[C@@H1](F)CNC(=O)C2=CC=NC(CO)=C2)C1 COC(=O)C1=CC=C(CCC(=O)NC[C@H1](C)CN2CCN(C)CC2)C=C1 CCCCO[C@@H1](C)C(=O)N[C@H1](C)CCCNC(=O)C1=CN=C(OC)N=C1C(F)F CC(C)C1=NC=C(C(=O)N[C@@H1]2CCCN(C(=O)C3=COC4=CC=CC=C4O3)C2)S1 O=C(C1CC2(CCN(C(=O)C3CC4(CC4)C3)C2)C1)N5C[C@H1]6CC[C@@]6(CO)C5 CC1=CC(C(=O)N2C[C@H1](O)C[C@@H1](NC(=O)C3CN(CC(C)C)C3)C2)=N[NH1]1 CC1=CN(C)[NH1]C1=NC(=O)[C@@H1]2CC=CC[C@H1]2C(N)=O CC1=CC=C(OCCC(=O)N2CC[C@H1](NC3=CC=NC4=NC(C)=NN34)C[C@@H1]2C)C=C1 C#CC1=CN=C(C(=O)N[C@@H1](C)C2=CN(C3=CC(OC)=CC=C3Cl)N=N2)C(C)=C1 CC[C@H1](CC(=O)N1C[C@@H1]2C[C@H1]3C[C@H1]2[C@H1]1[C@@H1]3NC(=O)C4=CN5C=CN=C5S4)OC CO[C@@]1(C(=O)N2CC3(CO[C@@H1](C)C3)C2)CCN(C(=O)CC4=CC=C(F)C=C4)C1 O=C(NC1CC(CNC(=O)[C@H1]2[C@@H1]3CCCCC[C@@H1]32)C1)C4=CN=C5C(=N4)CCCC5 CCOCCC(=O)N[C@]12CCN(C(=O)C3=CN=C(C(C)(C)CF)OC3)C[C@H1]1C2 CN1CCN(C(=O)CCCSC(C)(C)C)[C@H1](CNC(=O)C2CC3(CC3)C2)C1 CON=CC(=O)N[C@]1(C2CC2)CCN(C(=O)CC3=CSC(C4CC4)=N3)C1 CC=1N=N[NH1]C=1C(=O)N2CC[C@@](CO)(CNC(=O)C=3C=NN(C)N=3)C2 CN=C1[NH1]C(C(=O)N[C@@H1]2CCCC23CN(C(=O)[C@H1]4CN5CCCN4CC5)C3)=CS1 CC1=C[NH1]N=C1C(=O)N[C@@H1]2CC[C@](F)(CNC(=O)C3=CC=C4C(=C3)COCC4)C2 CC(C)C[C@@H1](C(N)=O)C(=O)N[C@H1](C)[C@@H1](CO)NC(=O)C1=CC2(CCOCC2)C1 CC1=CC=C(F)C(C(=O)N2CCC(CN(C)C(=O)[C@H1]3CCC(=O)O3)CC2)=C1 CC(C)C1=N[NH1]C(=NCC2CC3(C2)CC(NC(=O)C=4C=NN(C(C)C)C=4)C3)O1 CCN1C=CC(CC(=O)NC[C@@]23C[C@@H1]2CN(C(=O)C4CCS(=O)(=O)CC4)C3)=N1 CC1=NO[C@@H1](C(=O)NC[C@H1]2CCN(C(=O)CCNC(=O)CO)C23CCC3)C1 O=C(N[C@H1]1CCC[C@H1](C(=O)N2CC3=CC=NC=C3C2)CC1)C4CCCCC4 CCC[C@@H1](CO)NC(=O)[C@]1(C)C[C@@H1](O)CN1C(=O)C=2OC=C3C=2CCC3 CN1CCC[C@H1](C(=O)NC2(CNC(=O)[C@H1]3C[C@](O)(C#N)C3)CCCCCC2)C1 CC[C@@H1](C)CC(=O)N[C@H1]1C[C@@H1](NC(=O)CN2CC(=O)NC3=CC=CC=C32)C1 C[C@H1](OC[C@@H1]1CCCCO1)C(=O)NC[C@@H1]2CC[C@@H1](NC(=O)CCNC(N)=O)C2 CC1=C(Cl)C=CC(CC(=O)N(C)CC2(CNC(=O)[C@@H1](C)P(C)(C)=O)CC2)=C1Cl CCC[C@H1](CNC(=O)CC1(COC)CCCC1)NC(=O)C[C@H1]2CCOC2=O C[C@@H1](CNC(=O)C1CCCCC1)N2C=C(C3(N(C)C)CCC3)N=N2 CCN(C(=O)CC=1C=C(C)[NH1]N=1)C2CCN(C(=O)[C@@H1]3[C@@H1](C)C3(F)F)CC2 COC1=CC=NC(C(=O)NC[C@@H1](NC(=O)[C@@]23COC[C@@H1]2C3)C(C)C)=C1O CCNC(=O)C(=O)N1C[C@@H1]2C[C@H1]1CN2C(=O)[C@H1](C)CC3=CC=C(C(C)(C)C)C=C3 CC1=NN=C(CC(=O)N2C[C@@H1](NC3=CC(=O)N(C)C(=O)N3C)C[C@H1]2C)O1 C[C@@H1]1[C@H1](C(=O)N2CC[C@@H1](CNC(=O)C[C@H1]3CCCC34CC4)C2(C)C)[C@@H1]1C CN(C[C@H1]1CCCN1C(=O)CC2(C3=CC=CC=C3)CC2)C(=O)C4(CO)CC4 O=C(CCC1=CN=C2N=CC=CN12)N3CCN(C(=O)C4=CC=CC=C4)CC3 CCCN1C=CC(C(=O)N2CC[C@@H1](NC(=O)[C@@H1](C)S(=O)(=O)C(C)C)[C@@H1]2C3CC3)=N1 CCN(CCNC(=O)[C@@H1](C)CC1=CC=CO1)C(=O)CN2N=C(O)C=CC2=O C[C@@H1]1[C@H1](C(=O)NCC2(C)CC3(CC3)C2)CCN1C(=O)CC4OCCCO4 CO[C@@H1]1C[C@H1]1C(=O)NCCC[C@H1](C)NC(=O)CS(=O)(=O)N2CCCCC2 C[C@H1]1CCN(C(=O)CC=2C=CN(C)N=2)CCN1C(=O)[C@H1]3CCCN4C=NN=C43 CCC1=NN=C2C(C(=O)N3C[C@@H1]4C[C@H1]3[C@@H1]4NC(=O)C5(C)CCC5)=CC=CN12 C[C@@H1]1N([C@@H1](C(=O)NC(C)(C)C)C2=CC=C3C=COC3=C2)CCOC1(C)C CCNC(=O)CCCC(=O)N[C@H1](C)[C@H1](C)NC(=O)/C=C/C1=CC=C(Cl)S1 O=C(CCC1=CC(Cl)=NO1)NC[C@H1](O)CNC(=O)C=2C=C(CO)ON=2 CC1=C(C(=O)N2CC=C(CNC(=O)C=3SC(C(F)(F)F)=NC=3C)CC2)N=NN1C CCSC1=CC=C(C2=CC=C(NCC3=CC(F)=C(Br)C=C3[N+1](=O)[O-1])C(F)=C2)C=C1 C#CC1=CC=CC=C1CC(=O)NC[C@]2(C(F)F)CCN(C(=O)C3(C=C)CC3)C2 COC1(CNC(=O)[C@H1](F)C2=CC=C(F)C=C2)CN(C(=O)C3=CC(=O)N(C)O3)C1 CC1=CC([N+1](=O)[O-1])=CC(C(=O)N[C@H1]2CCN(C(=O)CC=3N=C[NH1]N=3)C24CC4)=C1Cl COC(=O)C12CCC(C(=O)CN(C)CC3=CC=C(F)C(F)=C3)(CC1)CC2 C[C@]1(C(F)F)C[C@H1]1C(=O)NCC2=CC=C(C(=O)N3CCC[C@H1](CC(N)=O)C3)N=C2 N#CC[C@@H1]1CCCN(C(=O)N[C@@H1]2CCCN(S(N)(=O)=O)C2)C1 COC[C@@H1](O)C(=O)N[C@@H1]1CCC[C@@H1](NC(=O)C2=NC(C(F)(F)F)=CC=C2F)C1 CN1N=CC(C[C@H1](NC(=O)CSC2CC2)C(=O)NCC[C@H1]3C[C@H1](F)C3)=C1O C[C@@H1]1OC2(CNC(=O)C(C)(C)F)CC1(NC(=O)C3=CC4=CC=CC=C4[C@H1]3O)C2 CCC1=CC=C(C)C(C(=O)N(C)CCNC(=O)CCC2=C[NH1]C(=N)[NH1]2)=C1 CC1=NC(CCCC(=O)N[C@@H1]2CN(C(=O)C3COC3)CC[C@H1]2CO)=CS1 CC[C@H1](C)/C=C/C(=O)N1C[C@@H1]2CN(C(=O)C3=CN(C4CCC4)N=N3)C[C@H1](C1)O2 C#C[C@]1(NC(=O)C2=COC([C@H1](C)NC(=O)CCCNC(=O)OC)=N2)C[C@@H1]3CCC[C@@H1]31 CCCCCCCCN(C)C1=CC(NC[C@H1](CO)C(C)C)=NC=N1 CN(C(=O)[C@H1]1CC12CCCCC2)C3(C(=O)N[C@@H1]4COCCC4(F)F)CC3 CCC1(C#CC(=O)NCC2=CC(O)=NC(CNC(=O)C[C@@H1]3CC[C@H1](C)O3)=N2)CC1 COCC[C@@H1](CNC(=O)C1(C2CCCC2)CCC1)NC(=O)C=3C=C(C)[NH1]C=3C CO[C@H1]1C[C@H1](C(=O)N2CCC3(CCN(C(=O)C=4C=NN(C5CC5)C=4C)CC3)C2)C1 CO[C@H1]1CCCN(C(=O)C2=CCN(C(=O)C(F)F)CC2)CC1 CCCCSCCC(=O)N[C@H1]1CCN(C(=O)C=CC2=CC=C(OC)C(F)=C2)[C@@H1]1C CC(C)(C#CC(=O)N1CCOCC1)CNC(=O)CCCCCN=[N+1]=[N-1] CC(C)C#CC(=O)NC[C@H1]1C[C@H1](NC(=O)CCC2=C[NH1]C3=NC=CC=C23)C[C@H1]1O CN(C[C@]1(O)CCS(=O)(=O)C1)C2=NC=CC3=CC=C([N+1](=O)[O-1])C=C23 COC=1C=C(C(=O)N(C)C[C@@H1]2C[C@H1](F)CN2C(=O)C[C@H1]3CCCC(=O)N3)N(C)N=1 CCN(C[C@@H1](C)NC(=O)C1=CN=C(SC)N=C1O)C(=O)C2=CC=3SC=C(Cl)C=3[NH1]2 COC(=O)N(C)CCCC(=O)N1CC[C@H1]2[C@@H1]1C[C@H1]2NC(=O)CN3C=NN=N3 CN1C=NN(CC(=O)NC[C@@]2(C)CCCN2C(=O)COC[C@H1]3CCCCO3)C1=O O=C(COCC(F)F)N1CC[C@@]2(CCN(C(=O)CN3N=CC4=CC=CC=C43)C2)C1 CCC[C@@H1](CC)C(=O)NCC1=NC(C(=O)NCC2=NN=NN2CC)=C(C)O1 C=C[C@H1](C1CC1)N(C)C(=O)[C@H1](CCNC(=O)CN2C=CC=NC2=O)OC CO[C@H1](C)[C@@H1](O)C(=O)N1CCC(CNC(=O)C=2C=NN(CCO)C=2C)(OC)CC1 C[C@H1](NC(=O)C=1C=CN(C)C(=O)C=1O)[C@@H1](C)NC(=O)C2(C3(O)CCOCC3)CC2 CC(C)(C)C#CC(=O)N1CCC2=CC=CC=C2[C@@H1]1CNC(=O)[C@@]3(O)CCOC3 CC1=C(C#N)C=CC=C1C(=O)NC[C@@]2(O)CCCN(C(=O)C3=CC=C(Cl)C=C3)C2 O=C1NOC[C@@H1]1N2CCC(NCC=3C=C(C(F)(F)F)ON=3)CC2 CCC[C@H1](C)C(=O)N[C@@]1(C)CCCN(C(=O)C=2C=CN(CC(C)C)N=2)C1 CC1=CC(C(=O)N[C@@H1]2CN(C(=O)C3=NN(C)C=C3Cl)C4(CCC4)C2)=C(C)C=C1Cl C#C[C@]1(O)C[C@@H1](C(=O)NCCCCCNC(=O)[C@](C)(O)[C@@H1]2CCOC2)C1 C=C(C)CCCC(=O)N[C@H1]1CCC[C@H1]1CNC(=O)C2=CC=3SC=CC=3[NH1]2 CC=1SC(=O)N(CCC(=O)N2CC[C@@H1](NC(=O)CSC(F)(F)F)C2)C=1C CCC=1N=C(C)OC=1C(=O)N2[C@H1](C(=O)N(C)CC3(O)CCCC3)C[C@@H1]4CCC[C@@H1]42 CC1=NSC=C1C(=O)N2CC[C@H1](NC(=O)[C@@H1]3CSC4=CC=CC=C43)C5(CCC5)C2 CCC1=CC=C(C(=O)N(C)[C@@H1]2CN(C(=O)C=CC3=CC=CC=C3C)C[C@H1]2F)N=C1 CC1=CC=CC(C(=O)NCC2=NN=NN2C3=CC=CC=C3)=C1I CSCCCNC(=O)[C@H1](C1=CCCCCC1)N2CC[C@@H1](N3CC[C@H1](O)C3)C2 CN(CCNC(=O)CCC(=O)C1=CC=C(O)C=C1)C(=O)CCCN2CCCCC2 CN(C)[C@H1](CNC(=NCCCCl)NC[C@@H1]1CCOC1=O)C2CCCCC2 CC(C)[C@]1(C(=O)N[C@@H1](CO)C2CCCC2)CCN(C(=O)CC3=NC=CC=C3F)C1 CN(CCCCN(C)C(=O)C1(C)CCCCCCC1)C(=O)C23CC(CO2)C3 CN1C=NC=C1C(=O)NC2CC3(CC(CNC(=O)[C@H1]4C[C@H1]5C=C[C@H1]4C5)C3)C2 CC(C)[C@@H1](O)C(=O)NC[C@@H1]1CN(C(=O)[C@@H1](C)N(C)CC2=CC=CC=C2)CCO1 C#C[C@H1](C)NC(=NCCCC1=CC=CC=C1Br)NCC2=CC=CN=N2 CC(C)[C@](C)(CNC(=O)C1=CSC(Cl)=N1)NC(=O)C2=C[C@H1]3CC[C@@H1](C2)C3 C[C@H1](NC(=O)C1=CC(F)=CC=C1Cl)C2CN(C(=O)C3=CC4=CC=CC=C4C3)C2 CC(C)N(CC(=O)N(C)[C@@H1]1CCOC[C@@H1]1C)C(=O)C2=NN(C)C=C2Cl CC[C@@H1]1C[C@@H1](CC(=O)N2CC=C[C@H1](NC(=O)C(F)(F)C(F)(F)F)C2)CCO1 O=C(C=1C=CN2C(Br)=CN=C2C=1)N3CCOC[C@](O)(C(F)(F)F)C3 CC#CCCCC(=O)N1CCC[C@@H1](CN(C)C(=O)C2=CC=C(F)C(O)=C2F)C1 CCOC1=NC(C(=O)N2[C@H1]3CC[C@@H1]2CN(C(=O)[C@](C)(NC(C)=O)C(C)C)C3)=NS1 CCCCCC[C@H1](C)C(=O)N[C@H1](C(=O)N1C[C@@H1](COC)C1(C)C)[C@@H1](C)OC CN1CC(C)(C)C[C@H1]1C(=O)N2CC3(C2)[C@H1](NC(=O)C=C(Cl)Cl)CCS3(=O)=O C[C@H1](CCCNC(=O)C1=CC=CN2C=NN=C12)CCNC(=O)[C@H1]3CCCCN3C CN(C(=O)C1=CC=C(O)N=C1)C(C)(C)CC(=O)N2CCC[C@@H1]3NC(=O)C[C@H1]32 O=C(OCC[C@@H1]1C[C@H1]2CC[C@H1]1O2)C3=NC=CC=C3C4=CC=CC(F)=C4 O=C(N[C@H1]1CCN(C(=O)CC(F)(F)Cl)C[C@@H1]1O)C2=CN=C(C3=CN=CC=N3)S2 COC=CC=C(N1N=NN=C1[C@@]2(NCC#CC(C)(C)O)C[C@@H1]3C[C@H1]2C[C@H1]3F)C=C CCN(CCCNC(=O)[C@@H1]1CC[C@@H1](CN2C=CN=C2)O1)C(=O)[C@@]3(C)CCOC3 CSCCCCC(=O)N1CC[C@]2(C)CN(C(=O)[C@H1]3CCCC(=O)N3)C[C@H1]12 CC1=C(C(=O)N2C[C@@H1](NC(=O)C=3C=CSC=3Cl)C(C)(C)C2)N=CN1C CC(C)C=1C=CSC=1C(=O)N2C[C@H1](C)C[C@@H1](NC(=O)CCCC3=NC=CS3)C2 COC[C@]1(NC(=O)[C@H1](F)C(F)(F)F)CCCN(C(=O)C=C2CCCCC2(C)C)C1 CC1=CC=CC=C1C2=CC(C(=O)NC[C@@H1](O)CN=C3C=C[NH1]C=C3C#N)=NO2 CCOCCOCCC(=O)NCCCNC(=O)CC1=CN=CC(C)=C1 CO[C@H1](CNC(=O)[C@@](C)(C1CC1)N(C)C(=O)C2=CC=C(C3CC3)C=C2)CSC CC/C=C/CC(=O)N1CC(O)(CN(C)C(=O)C[C@H1](CN(C)C)C(F)(F)F)C1 O=C(C=C[C@H1]1CCCO1)N2[C@H1]3CC[C@@H1]2C[C@H1](CNC(=O)C45CCC(CC4)OC5)C3 CC(=O)OC[C@H1](C)C(=O)NCC=1OC=CC=1C(=O)N2CC[C@@H1](F)[C@H1](O)C2 C[C@@H1](NC(=O)C1(N2C=C(F)C=N2)CC1)[C@H1]3CCCCN3C(=O)C4=CN=CC(Cl)=C4 C[C@@H1]1C[C@@H1]1CNC(=NCCC2=CC=CC3=CC=CC=C23)NC4CCC4 COC1=CC(C(=O)NC[C@H1]2C[C@H1](NC(=O)[C@H1](O)CC[S@@](C)=O)C2)=NN=C1C3CC3 CC1=NC=C(C(=O)N[C@H1]2C=CCC[C@H1]2C(=O)N3CCC[C@H1]3C)S1 O=C(CC1=CN=C[NH1]1)N[C@@H1]2CCC[C@H1](NC(=O)C3=CC(C4CCC4)=NO3)C2 COC(=O)C=1C=C(NC(=O)[C@H1]2C[C@@H1]2NCC3=CC=CC=C3[N+1](=O)[O-1])N(C)N=1 CC(C)[C@@H1](C)NC(=O)N1CCC[C@H1](C2=NC=C(Br)C=N2)C1 CC(C)CSCC(=O)N1C[C@H1](CNC(=O)COC[C@@H1]2CCOC2)OC3(CCC3)C1 O=C1C[C@H1](C(F)(F)F)[C@H1](C(=O)NCC#CCNC(=O)C2CC(F)(F)C2)N1 CN(CCNC(=O)[C@H1]1CCCN2C=CN=C21)C(=O)[C@H1]3COC4(CCC4)CO3 C[C@H1](CN(C)C(=O)[C@H1]1[C@H1]2C(=O)CC[C@H1]21)NC(=O)C3=CN=CC4=CC=C(F)C=C34 CCC1=CC=NC(C(=O)NCC2CN(CC(=O)N[C@@H1]3CCOC3=O)C2)=C1 O=C(C[C@@H1]1CCOC1=O)NC[C@@H1]2CC(F)(F)CN2C(=O)[C@@H1]3CCCCN3C CC=1N=CSC=1C(=O)N[C@@H1]2CC[C@H1]2NC(=O)C=3C=C([N+1](=O)[O-1])C4=NSN=C4C=3 CN1C=CC(C2CCN([C@H1](C(=O)NCCCF)C=3OC=CC=3Br)CC2)=N1 CCN1C=CC=C1C(=O)N2CC[C@H1](NC(=O)C=3SC=C4C=3OCCO4)[C@H1]2C CN[C@]1(C(=O)N2CCC3=CC=CC(C)=C3C2)CC1(F)F CC1=CC=CC(C2=CC=C(C(=O)NCC=3C=COC=3)N2C)=C1 C[C@H1](CNC(=O)C1=NO[C@@H1](C(C)(C)C)C1)NC(=O)CCC=2C=CSC=2Cl CS[C@H1](C(=O)N(C)CCNC(=O)[C@@]1(C)CCCS1(=O)=O)C(C)C CCCN1N=C(C2=NC(C[C@@H1](C)OC)=NN2C3CCCC3)C4=CC=CC=C4C1=O C[C@@H1](CNC(=O)C1=CC=CN=C1N2CCCC2)CN(C)C(=O)[C@@H1](O)CC(C)(C)C CCCC=1C=C(C(=O)NC[C@@H1]2CCC[C@@H1]2NC(=O)CCN3C=CC(C)=N3)N(C)N=1 O=C(C1=CC=2SC=NC=2[NH1]1)N3CC4(CCCN4C(=O)C=5SC=NC=5C6CC6)C3 CC1=CC=CC=C1[C@]2(F)CCN(C3=NC4=C(C(=NCC5(Br)CC5)[NH1]3)COC4)C2 CSC(C)(C)/C=C/C(=O)NC[C@@H1]1C[C@H1]2CN(C(=O)C3=CN(C)C(C)=CC3=O)C[C@@H1]12 CN(CCCC(C)(F)F)C(=O)C1=CN(CCNC(=O)[C@@H1]2[C@H1]3COC[C@H1]32)C=N1 CC[C@@H1](CN(C)C(=O)[C@@H1]1C[C@H1](F)C(=O)N1)NC(=O)C2=NN(C)C(O)=C2 COCCCC=1N=C(CC2=CC(C3CCC3)=NO2)N(C4=CC=C(C)C(F)=C4)N=1 CC=1C=C[NH1]C=1C(=O)N2C[C@](C)(C(=O)N[C@@H1](C)CN3CCCCC3)CC2(C)C CCC1=NN(C)C=C1C(=O)N2C[C@@H1](NC(=O)C=C(C)C)C[C@]2(C)CC CC(=O)N(C)CCC(=O)NCC1CC(NC(=O)[C@]23CCCC[C@@H1]2C3)C1 COC(=O)[C@@H1]1O[C@@H1](C(=O)N2CC[C@@H1](CNC(=O)C3=NSN=C3O)C2)C[C@H1]1C CC1(C#CC(=O)N[C@@H1]2CC[C@](F)(CNC(=O)[C@@H1]3CC4(CCCCC4)CO3)C2)CC1 CCN1CCN(CC(=O)N[C@@H1]2CCN(C(=O)C3=CSC(C4CC4)=N3)C[C@@H1]2C)CC1 CN(C)[C@@H1](CO)C(=O)NC1[C@H1]2C[C@H1]1CN(C(=O)COC3=CC=C4C(=C3)CCC4)C2 CC1=CC=C(C2=CC(C(=O)N3CCOC[C@H1]3CO)=C4C=N[NH1]C4=C2)C=C1 CC(=CC(=O)N1CC[C@@]2(CCCN(C(=O)CCCN3C=CC=C3)C2)C1)C4CC4 CCCCS[C@@H1](C)C(=O)N[C@@H1](CNC(=O)CC1=CC=C(C)O1)C2=CC=C(F)C=C2 CC1=NN(C)C(=O)[C@@H1]1CC(=O)N2C[C@H1](C)C(NC(=O)[C@H1](CO)C(F)(F)F)[C@@H1](C)C2 CC1=CN=C(C#N)C(C(=O)N2CCC(C)(NC(=O)[C@@H1]3CCS(=O)(=O)C3)CC2)=C1 CC=1C(C(=O)N2CC[C@@]3(NC(=O)CN4CCOCC4)CCC[C@H1]23)=NOC=1C5CC5 O=C(COC1=CC=C(F)C(Br)=N1)N[C@H1]2C=CCC2 CCC(C)(CC)CN=C(NCCF)N1CCO[C@@H1](C2=CC=CC=C2Cl)C1 C[C@@H1]1CCC[C@]1(C)C(=O)N[C@H1]2CCN(C(=O)C=3C=CC4=NSN=C4C=3)[C@@H1]2C CC[C@@H1]1CCC[C@]1(C)C(=O)N[C@H1]2CCN(C(=O)[C@@H1](CC)CC3CCCCC3)[C@@H1]2C C[C@@H1](NC(=O)CC1=C[NH1]N=C1O)[C@@H1]2CCN(C(=O)C3=CC(=O)C=C(Cl)[NH1]3)C2 CCC[C@H1](OC)C(=O)N[C@H1](C)[C@@H1](CO)NC(=O)CCNC(=O)OC(C)(C)C CC1=CN=CC(C)=C1C(=O)NCC[C@H1]2CCN(C(=O)[C@H1](C)[C@H1](O)C(C)C)C2 C=C[C@@H1](O)C(C)(C)C(=O)N1CC2(C[C@H1]2C(=O)N3CCN4C=NC=C4C3)C1 C=C(C)CNC(=O)[C@H1]([C@H1]1CCC[C@H1]1C)N2CC=C(C3=CC=C(Cl)C=C3)CC2 C[C@@H1]1C[C@H1](C(=O)N(CC2CC2)[C@H1]3CCCN(C(=O)[C@H1](C)C#N)C3)CCO1 COC1=CC(C(=O)NC[C@@H1](C)CN(C)C(=O)[C@@H1](C)N2C=CC=N2)=CC=C1C COC(=O)CSCC(=O)N[C@H1]1C[C@@H1](NC(=O)C[C@@H1](CN)C(=O)OC(C)(C)C)C1 C[C@H1](C(=O)N[C@H1]1C[C@@H1]2CC[C@H1](C1)N2C(=O)CCCN=C3N=CC=C[NH1]3)S(N)(=O)=O CC=CC(=O)NC[C@H1]1[C@H1](CC)CCN1C(=O)CCNC(=O)C2=CC=CC=C2Cl CC1=CC(C(=O)N(CCO)CCCNC(=O)C2=C(C3CC3)C=NN2C)=CN=N1 CCCC(=O)NCC(=O)N[C@@H1]1CCC[C@H1]1NC(=O)CN(C)C(=O)C2CC2 CCOC(=O)[C@@H1](F)C(=O)N1CC(OCC(=O)N[C@@H1](CO)C[C@H1](C)CC)C1 CC1=CSC(C)=C1C(=O)NC[C@H1](NC(=O)CCOC(C)C)[C@@H1](C)C(C)C COC1=CC=CC(Cl)=C1[C@H1]2C[C@H1]2C(=O)N[C@@H1](C)C3CN(C(=O)C4=CC=CN=C4)C3 CC1=CC=2SC(C(=O)NC[C@@H1]3CCN(C(=O)[C@@H1]4CN5CC[C@H1]4C5)C3)=CC=2S1 CC=1C=C(C(=O)N[C@@H1](CNC(=O)C[C@H1]2CC3(CCC3)CO2)CC(C)C)N(C)N=1 COC[C@@H1](CC(C)C)C(=O)NCC1(CNC(=O)C(C)(C)CCC#N)CCCC1 CCC[C@@](C)(O)CC(=O)NC[C@H1]1C[C@@H1](O)CN1C(=O)CN2C=C(C)C=CC2=O O=C([C@@H1]1CC[C@H1]2C[C@H1]2CC1)N(CCNC(=O)C(F)(F)CO)CC3CC3 CN1N=NN=C1[C@H1](NCC2(OCCO)CCCCC2)C3=CN=C(C(F)F)S3 CCSCCCCNC(=O)[C@@]1(C)C[C@@H1](O)CN1C(=O)C2=CC=NC=C2CC CCNS(=O)(=O)C1=CC=CC(C(=O)N(C)[C@H1]2C3=CC=CC=C3C[C@@H1]2O)=C1 CSC[C@](C)(NC(=O)[C@H1]1CC[C@@H1](O)CN1C)C(=O)NC2=CC=CC([C@@H1](C)F)=C2 C[C@H1](NC(=O)C1=CN=C[NH1]1)[C@@H1]2CCCCN2C(=O)CN(C)C(N)=O CC1=NOC(Cl)=C1CCC(=O)N[C@@H1]2CCN(C(=O)C3=CC(N)=NC(Cl)=C3)C[C@H1]2F NC(=O)CCCCC(=O)N1CC[C@H1](C2(NC(=O)C3=CC=NC(C4CC4)=N3)CC2)C1 CCCCO[C@@H1](C)C(=O)NCC1(O)CN(C(=O)CC2=C(Cl)C=NN2C)C1 CC[C@H1](CC(=O)N1CC[C@@](O)([C@H1](C)NC(=O)CCCC(N)=O)C1)OC COCC=1N=N[NH1]C=1C(=O)NCC2CN(C(=O)C(C)(C)C=3C=CN(C)N=3)C2 COC1=CC(F)=CC=C1[C@@H1](NC[C@@H1](F)CO)C2=NN=NN2C3(C)CC3 C[C@H1]1OCC[C@@H1]1C(=O)NC2CC3(CCN(C(=O)C4=CN5N=CC=CC5=N4)C3)C2 CCC=C(F)C(=O)N(C)C[C@@H1](C)NC(=O)/C=C/C1=CC(C(N)=O)=CC=C1OC COC=1C=C(C(=O)N2CC[C@H1](CCNC(=O)C3=CCC[C@@H1]3C)C2)SC=1Cl C/C=C/C[C@H1](C)C(=O)N1CC[C@@H1](NC(=O)[C@H1]2C[C@@H1](NS(C)(=O)=O)C2)CC(C)(C)C1 C[C@@H1](O)[C@@](C)(O)C(=O)N[C@@H1](C(=O)N1CCCCC1)C2=CC=CC=C2 C[C@H1](CC(=O)N1CC(CO)C1)NC(=O)[C@]23CSC[C@H1]2C3 C[C@H1](CNC(=O)COC1CCCCC1)N2C=C(CCN3CCCC3)N=N2 C[C@H1]1CN(C(=O)[C@H1](O)C2=CN=C[NH1]2)C[C@@H1]1CNC(=O)C(=O)NC3=NC=C[NH1]3 O=C(NC1(CNC(=O)C23CC(C2)C3)CCC1)C4=CC(O)=NC5=CC=C(F)C=C45 CC1=COC(C)=C1C(=O)N[C@H1](C)CC2CN(C(=O)[C@H1](C)[C@H1]3CCCO3)C2 C[C@@H1]1C[C@H1](C(=O)N(C)C2C[C@@H1]3CC[C@H1](C2)N3C(=O)CCOC4CC4)CCC1=O C[C@@H1](CN1C=CN=C1)C(=O)NC[C@@H1]2CCCN2C(=O)CC3=NSC4=CC=CC=C34 CC[C@@H1](O)C(F)(F)C(=O)N1C[C@@H1](NC(=O)CNC(=O)C2=CC=CS2)CC(C)(C)C1 CN(C)CCCCC(=O)NCCOCCC(=O)NCC(C)(C)[C@@H1]1CCCO1 CN(CCCNC(=O)C=1C=C[NH1]C=1C2CC2)C(=O)C[C@@](C)(N(C)C)C(F)(F)F CCOC(=O)[C@H1](NC(=O)[C@H1](CNC(=O)[C@H1]1CC(=O)C12CCC2)OC)C3CC3 CCO[C@H1]1C[C@@H1](NC(=O)[C@@H1](C)[C@H1]2CCCN(C(=O)CC=3C=CSC=3)C2)C1 O=C(N[C@H1]1CCCN(C(=O)C2(CCO)CC2)CC1)C3=NC=NC(O)=C3F CN1C=CC(C(=O)N2CC3(CC(CC(=O)N[C@@H1]4C[C@H1]4C5CCCC5)C3)C2)=N1 CN(NC(=O)C1=CSC2=CC=CC(Br)=C12)C(=O)OC(C)(C)C O=S(=O)(NCC1(NC2=NC=NC=3C=CSC2=3)COC1)C4CCCCC4 CC(C)(O)C#CC(=O)N1CCS(=O)(=O)CC2=CC=CC=C21 C#CC1(C(=O)N2CCO[C@H1]([C@@H1](C)NC(=O)C3=CC=C(S(C)(=O)=O)C=C3)C2)CCC1 C[C@@H1](CC1=CC=CC=C1)C(=O)N2CCC(CN(C)C(=O)C=3C=N[NH1]C=3)CC2 CC1(C)CC[C@@H1](CNC(=O)C2=CSC(CO)=N2)N(C(=O)C[C@@H1]3CCS(=O)(=O)C3)C1 O=C(NC[C@@]12CCC[C@@H1]1C2(F)F)NC[C@@]34CCC[C@@](F)(CO3)C4 C[C@H1](CNC(=O)CCCS(N)(=O)=O)CN(C)C(=O)C[C@H1]1CN2CCN1CC2 CC[S@](=O)C1=CC=CC=C1C(=O)N[C@H1]2[C@@H1]3CN(C(=O)[C@H1](C)SC(F)(F)F)C[C@@H1]32 CN=C1[NH1]C=C(C(=O)NCC[C@@H1](C)N(C)C(=O)C2=CC=CN=N2)S1 CC1=CC=C([C@H1](F)C(=O)N2CC3(CCC[C@H1]3NC(=O)C4=CCCC[C@H1]4C)C2)C=C1 CO[C@](C)(C(=O)NC[C@H1]1COCCN(C(=O)C2=NC=C(Cl)N=C2Cl)C1)C3CC3 COC(=O)C1=CC(C(=O)N2CCC[C@H1]2CCCCF)=CC=C1F CC1=CC=C(CN2CC[C@@H1](CNC(=O)[C@@H1]3CCCN(C(=O)C(C)C)C3)C2)C(C)=C1 C[C@@H1]1CN(C(=O)C[C@@H1]2CN(C(=O)C=3C=CON=3)CCO2)C[C@H1]1N(C)C CC(C)[C@H1](CNC(=O)N[C@H1]1C[C@H1](C2=CC=CC(O)=C2)C1)C3=CC=NN3C CSC=1C=CSC=1C(=O)N(C)[C@@H1]2CCCN(C(=O)[C@]3(C)CCC(F)(F)C3)CC2 CCC[C@@H1](CCO)NC(=O)[C@@H1]1CC[C@H1](CNC(=O)C(C)(C)[C@@H1](C)O)O1 CC(C)(F)C(=O)NC[C@H1]1CN(C(=O)C[C@H1]2CC3(CCC3)CO2)CC4(CCC4)O1 CC(C)NC(=O)[C@@H1]1C[C@H1](C)CN1C(=O)[C@@H1]2C[C@@]2(F)Cl N#CC1=C[NH1]C=NC1=N[C@H1]2C=C[C@@H1](C(=O)NC3=CC=NC(O)=C3)C2 CC=1[NH1]N=C(C(=O)N[C@@H1]2CN(C3=NC=NC(Cl)=C3CO)C[C@@H1]2F)C=1C CC[C@@H1](C)C(=O)N(C)[C@@H1]1CCN(C(=O)C2=C(C)C=CC(C)=C2C)C1 CCC(CC)C(=O)NCCCN(C(=O)C=1C=CC2=CN=CN2C=1C)C3CC3 C#CCCCCCCC(=O)N1CCC[C@](O)(CCNC(=O)C2CC(C)(F)C2)C1 CSCC(=O)NCCC1CCN(C(=O)C2=COC(C3=CC=CC=N3)=N2)CC1 CC1=CSC2=NC(CC(=O)N3C[C@@H1](NC(=O)[C@@H1](O)CCC(C)C)C[C@@H1](F)C3)=CN12 O=C(N[C@H1]1C[C@H1]2C[C@H1]1N(C(=O)CCOCC(F)F)C2)C3=CC=C(OC(F)F)C=N3 CO[C@@H1]1C[C@H1]1C(=O)NC[C@H1]2CCC3(CN(C(=O)C4=CC(F)=CC=C4Br)C3)O2 C=CC[C@H1](C)C(=O)N(C)C[C@H1]1CCCCN1C(=O)C2=CN=C3C(Cl)=CC=CN23 CN1C=C(C(=O)N[C@@H1]2C[C@@H1]3C[C@@H1](C(=O)O)C[C@@H1]32)N=CC1=O CN(C1CCCCC1)[C@H1](C(=O)NC2=CC=CC=C2)C3=CC(S(C)(=O)=O)=CO3 CC[C@@H1]1C[C@H1]1C(=O)N[C@@H1](CCN(C)C(=O)[C@H1]2CCC3=N[NH1]C(C)=C3C2)C(C)C CCC[C@]1(C)CCN1[C@@H1](C(=O)NCCOCC2=CC=CC=C2)[C@@H1]3C[C@@H1](C)C[C@@H1](C)C3 C=C(C)CC(=O)N1CC[C@H1]1CNC(=O)C2=CC=CC=C2SC(F)F CC[C@H1](NC(C)=O)C(=O)N1CCC[C@H1](C2CCN(C(=O)C=3SC=CC=3F)CC2)C1 COC1=CC=C(F)C(C(=O)N2C[C@@H1](NC(=O)[C@@H1]3C[C@H1]3[N+1](=O)[O-1])C(C)(C)C2)=C1OC CC(C)N1N=NN=C1[C@@H1](N[C@@H1]2CCC3=NC=C(Br)N3C2)C4=CC(C(C)(C)C)=N[NH1]4 CCSC[C@H1](NC(=O)C=1C=C(COC)ON=1)C(=O)N(C)CC=2C=N[NH1]C=2 CCC1=CC=C(C(=O)N2C[C@@H1](NC(=O)C3=CC4=C(S3)COCC4)C5(CC5)C2)C=C1 CS[C@@H1](C)C(=O)N1CCC[C@@H1](C(=O)NCCC(=O)N2CCC[C@@H1](C(=O)N(C)C)C2)C1 CCC1=CSC=C1C(=O)N2CC[C@@H1](NC(=O)[C@@H1](C)N3N=CC=C3C)C24CCC4 CCN(CC)[C@H1](CNC(=O)C1=CC=CC([C@H1](F)C(F)(F)F)=N1)C2=CC=CC=C2 C[C@@H1](C(=O)N1CC[C@@H1](N(C)C(=O)C2=CC(C3(C)CC3)=CC=C2F)C1)C(F)(F)F CP(C)(=O)CC(=O)N1C[C@@H1]2C[C@H1]3C[C@H1]2[C@H1]1[C@H1]3NC(=O)CN4CCNC(=O)C4 CCN1CC[C@H1](NC(=O)[C@@H1](CC2CCCC2)NC(=O)C3=CC=CC(F)=C3N)C1 CN1C=CC(CCC(=O)N2CCCN(C(=O)C=3C=NN(C)N=3)C[C@@H1]2CO)=C1 CN1N=CC(C(=O)N2CC(F)(CNC(=O)C=C[S@](C)=O)C2)=C1C#N C[C@H1](C(=O)N1CC[C@@](CF)(NC(=O)C2=CN=C(Cl)S2)C1)C3CCCCC3 C[C@H1](O)CC(=O)N1CC[C@@](CO)(NC(=O)C2CCC3=CC=CC=C3CC2)C1 C[C@H1](C(=O)N1C[C@@H1]2C[C@H1]1[C@@H1]2CNC(=O)[C@@H1]3CC(=O)N[C@@H1]4CCCC[C@H1]43)C5CCC5 CC1=CN=C(NC(=O)C2=CC(Cl)=NC=C2NCC3=C(C)C=C(Br)C=C3C)C=C1F CSC=CC(=O)N1C[C@H1]2[C@@H1](C1)OCCN2C(=O)COCC3=NC=CN3C C[C@H1](CC(=O)NC[C@@H1]1CC(C)(C)CN1C(=O)CC(C2CC2)C3CC3)CC(F)(F)F CCCC(C)(C)CC(=O)N[C@H1]1CN(C(=O)[C@H1]2CC3=NN=CN3C2)CC4(CCC4)C1 CC(C)=C(C)C(=O)N1C[C@H1](O)C[C@@H1](NC(=O)C2=CC3=CC=CC=C3C=C2N)C1 O=C1C[C@H1](C(=O)NC2(CCF)CC(O)C2)N(C(=O)CN3C=CC=N3)C1 CC1=NOC(C(F)F)=C1C(=O)N2CC[C@H1]3CN(C(=O)CCOCC(F)(F)F)[C@H1]3C2 CC1=CC=C(C(=O)NCC2CN(C(=O)C3=CC=CC(N)=N3)C2)C(=O)N1C CCC1=CC=CC(C(=O)NCC#CCNC(=O)C[C@@H1]2CCS(=O)(=O)C2)=N1 CCCC1=CC(C(=O)N(C)[C@H1]2CCCN(C(=O)[C@@H1]3CCC4(CCC4)OC3)C2)=N[NH1]1 CO[C@H1](C(=O)NCC1(NC(=O)[C@@H1]2C[C@@H1]2C(=O)OC)CC1)C3CC3 CCC(CC)(CNC(=O)C1=CN=C(C)C(N)=C1)NC(=O)[C@H1]2COC3(CCC3)C2 C=CCC[C@@H1]1CCCN(C(=O)CN(C(=O)CCCC)C2=CC=CC=C2)C1 CC[C@H1](C)CC(=O)N[C@H1]1CCCN(C(=O)CCC2=NC(C)=C(C)[NH1]2)[C@@H1]1C COC[C@@H1](CNC(=O)CCCCCCNC(=O)C[C@H1]1CC[C@H1](C)CO1)OC COC(=O)[C@H1]1C[C@@H1]1C(=O)NC2=NC(CC(=O)NC=3C(Cl)=N[NH1]C=3C)=C(C)S2 CC1=CC(O)=CC(C)=C1C(=O)N2CCC[C@@H1]3CN(C(=O)C4=NOCC4)CC[C@H1]32 N#C[C@H1]1C[C@H1]1C(=O)N2C[C@H1]3C[C@]3(CNC(=O)CN4CCSCC4)C2 CC[C@@H1](C(=O)NCC[C@H1]1C[C@@H1](NC(=O)C2=CC(Br)=NO2)C1)C3=CC=C(F)C=C3 C[C@@H1]1C[C@@H1](CNC(=O)C2=CC=CC3=CN=CC=C23)CN1C(=O)C4SCCS4 O=C(CCCC1=CN=CC=N1)N[C@H1]2CCCCN(C(=O)[C@@]3(O)CCOC3)C2 CC1=NC2=C(S1)CN(C(=O)[C@H1]3CCC[C@@H1]3NCC4=CC=C(Cl)C([N+1](=O)[O-1])=C4)CC2 C#CC1=C[NH1]N=C1C(=O)N(C)CC(C)(C)C(=O)N2CCN(C3(C)CC3)CC2 CC[C@@](C)(CO)C(=O)NC1CC2(CCN(C(=O)C34CCC(CC3)C4(C)C)CC2)C1 O=C(NCC[C@H1]1CCCN1CCOC2CCC2)[C@H1]3CC4CCC3CC4 CCCCC(C)(C)NC(=O)[C@H1]1COCCN(C(=O)C2CCC3(CC2)CC3)C1 CCOC1=CC=C(Cl)N=C1C(=O)N[C@@H1](C)CN(C)C(=O)CNC(=O)OC(C)(C)C CC[C@@H1](C(=O)N(C)CC(C)C)N(C)C(=O)C=1C=C(C2CC2)ON=1 COC1=CC=C2C=NC(C(=O)N[C@]3(C)CCC4=CC(C(=O)O)=CC=C43)=CC2=C1 CC=C[C@@H1](O)C(=O)N1CCC[C@@](F)(CNC(=O)C=CC2=NC(C)=C(C)[NH1]2)C1 C[C@H1]1CC[C@H1](C(=O)N2CC[C@@H1](NC(=O)C3=NC=NC=4SC=CC3=4)C[C@@H1](O)C2)CC1 CC(C)[C@@H1](C#N)C(=O)NCCCCCC(=O)NC(C)(C)CC(C)(C)C CC(C)[C@]1(CO)CCN(C2=NC(N3CCC4=N[NH1]C=C4C3)=C5C=CSC5=N2)C1 CCCC1(NC(=O)C2=CC(C)=NC(O)=N2)CCN(C(=O)[C@]3(C)CCCCO3)CC1 CC[C@@H1](CN(CC)C(=O)[C@H1]1CCN1CC)NC(=O)C=C(C)C2=CC=CS2 C#CCCOCCNC(=O)[C@H1](CNC(=O)[C@H1](O)C(F)(F)F)C(C)(C)C CC(C)[C@@H1](CNC(=O)[C@H1](C)C1=CC=CC=N1)NC(=O)CC2=CC=C(Cl)N=C2 O=C(CCCN1C=CN=N1)NC2([C@@H1]3CCN(C(=O)CCCSC(F)(F)F)C3)CC2 CCN1C=CC=C1C(=O)NCC(C)(C)CC(=O)N2CCOC[C@H1]2COC C[C@H1]1CN(C(=O)C2=CC(F)=C(Cl)C=C2F)C[C@@H1]1N=C3C=CN=C(C4CC4)[NH1]3 O=C(N[C@H1]1CC[C@@H1](F)CN(C(=O)CCF)C1)C2=CC(Cl)=NC3=NC=CC=C23 C=C[C@H1](OC)C(=O)NC1CC(N(C)C(=O)C2=CC=CN2C)C1 CC(C)CCC(=O)C(=O)N[C@H1](C)[C@H1](C)C(=O)N1CCC=2[NH1]C=CC=2C1 C[C@H1](CNC(=O)C[C@@H1]1C[C@@H1](C)N(C(=O)C[C@@H1](O)CC(C)(C)C)C1)OCCO C#C[C@@]1(C(=O)NCC2=CC(C)=C(C)S2)CCN(C(=O)[C@@H1]3CN(C)C[C@H1](C)O3)C1 COC(=O)[C@@H1](CN1C=CN=C1)NC(=O)CC2(N)CCOCC2 CCOC(=O)[C@@]1(C#N)CCN(C(=O)NCC2=NN(C)C=C2I)C1 CC(C)C=1OC=CC=1C(=O)N[C@H1]2CCN(C(=O)[C@@H1]3CCCSC3)C[C@@H1]2O O=C(COC1=CC=CC=C1)NC2CCN(C(=O)CN3C=NC4=CC=CC=C43)CC2 CC1(C)[C@@H1](C(=O)N[C@@H1]2CCC23CCCC3)C[C@H1]1NC(=O)CN4C=NN=C4 CCC=1OC=NC=1C(=O)N[C@@H1]2CN(C(=O)C3=CC(Cl)=CC=C3O)C[C@@H1]2C COC1=CC=C(OCC(=O)N(C)C[C@@H1](O)CNC(=O)[C@@H1]2OCCOC2(C)C)C=C1 C[C@@H1]1CN(C)C[C@@H1]1C(=O)NC2=C3C(=CC4=C2CCC4)CCC3 C=CC[C@@H1](OC)C(=O)N(CC)CCN(CC)C(=O)[C@H1](O)CC O=C(NCC[C@@]1(O)CCN(C(=O)C2CCCC2)C1)C3=CSC(C4CCCCC4)=N3 CC1=CN=CC=C1C(=O)N2CCC[C@@H1]2C(C)(C)NC(=O)[C@@H1]3CC[C@@H1](N=[N+1]=[N-1])C3 C#CCC1(C(=O)NC[C@@H1]2CCC3(CCC3)[C@@H1]2NC(=O)C(=COC)CCC)CC1 COC1=CC=C(Cl)C=C1[C@H1](C)NC(=O)N[C@@H1](C2=CC=CC3=C2CCO3)C4CC4 CCOCCS(=O)(=O)NCC(=O)N1CCN(C(=O)[C@H1]2[C@@H1](C)[C@H1]2C)C[C@@H1]1CC CCC[C@@H1](CC)C(=O)N(C)CC1(O)CCN(C(=O)[C@]2(COC)C=CCC2)CC1 O=[N+1]([O-1])C1=CC=CC(N2C=C(C3=CC=CC(F)=C3Br)N=N2)=C1 CC1=N[NH1]C(C)=C1C(=O)N[C@@H1]2CN(C(=O)C3=C[C@@H1](C)CC3)C4(CCOCC4)C2 C[C@H1]1CC2=C[NH1]N=C2[C@@H1](C(=O)N(C)CCNC(=O)C3=NN=C(S)N3C)C1 CCC(CC)(CNC(=O)CCC(F)F)NC(=O)C[C@@H1]1CCCCC1(F)F CN1C(CNC(=O)NC2=CC3=C(C=C2C(=O)O)OCO3)=CC(Cl)=C1Cl C[C@H1]1CN(C(=O)C2(C)CCC2)C[C@@H1]1C(=O)N3CC[C@@H1](C4=CC=CO4)C3 CC(=O)NCC(=O)N1C[C@H1]2CCO[C@]2(CNC(=O)C=CC3=CC=NC=C3)C1 C[C@H1](CC(=O)NC[C@H1]1C[C@H1](CNC(=O)C[C@H1](O)C2=CC=CC=C2)C1)NC(N)=O COC1=CC=CC(F)=C1CC(=O)N[C@@H1](C)C[C@H1](C)NC(=O)C(C)(C)C2=CC=CS2 CCCC(=CC(=O)N1CC[C@H1](NC(=O)C2=C(C)C=NN2C)[C@H1](OC)C1)CCC N#CC1(CCF)CN(C(=O)[C@@H1]2CCCN2C(=O)CC[C@H1]3CCOC3)C1 CSC(C)(C)CN[C@](C)(COC(C)C)C1=NN=NN1CCN(C)C CC1=CC(C(=O)N2C[C@@H1](NC(=O)[C@H1](F)C(C)C)C(C)(C)C2)=C(C)C=C1Cl C=C1C[C@@H1]1C(=O)N2CC3(F)CC(CNC(=O)C4=CN5C=CN=C5C=N4)(C2)C3 CN1C=C(SCC(=O)N2CC[C@@H1]2CNC(=O)C3=CCCO3)C=N1 CC1=CC([N+1](=O)[O-1])=CC=C1N(C)[C@H1]2CCN(C(=O)[C@H1]3CC4=CC(F)=CC=C4O3)C2 CC[C@@H1](CNC(=O)C[C@@H1](C)OC)NC(=O)C(F)(F)SC1=CC=C(F)C=C1 CCS[C@@H1](C)C(=O)N[C@H1]1C[C@@H1](CNC(=O)C(F)=C2CCCC2)C1 C=CC[C@H1](C)C(=O)N[C@H1]1CCCOC12CCN(C(=O)[C@H1](CC)CCC)CC2 CC=C1C(C(=O)N[C@@H1]2CN(C(=O)C=C3CCCCC3(C)C)C[C@H1]2C4CC4)=CC(O)=N1 CC1=CC(C)=C(C(=O)N[C@H1]2CC[C@@H1](NC(=O)[C@H1](C)[C@@H1](C)O)CC2)C=N1 C1NC[C@]2(CCCN2C(=O)COC3=CC=CC4=C3CCN(C)C4=O)CC1 C=CCC(C)(CC=C)NC(=O)CC[C@@H1](C)NC(=O)C1=CC=CC(CO)=N1 C#CCCCN=C(NCC(=O)NCC=C)NC[C@@H1](SC)C(C)(C)C CN(C)[C@]1(C(=O)N2CCC(CCNC(=O)[C@H1](O)CC(F)F)CC2)CCCOC1 CCCN(CCNC(=O)[C@H1]1CCCS[C@H1]1C)C(=O)C=2C=CN(C(C)(C)C)C=2 COCC(=O)N[C@H1](C)C1(CNC(=O)C2=CC=CC(C(=O)NC3CC3)=C2)CC1 COCC[C@H1](CNC(=O)CC1=CC=C(C)N=C1)NC(=O)[C@]2(C)CCOC2 CC(C)CCC(=O)NNC(=O)CNC1=CC=NC=N1 CCCN(CCNC(=O)C(C)(F)F)C(=O)[C@H1]1CC2=CC=C(OC(F)F)C=C2O1 C[C@@H1]1COC[C@H1](CC(=O)N2CCN(C(=O)C3(CO)CCCC3)CC[C@H1]2C)O1 CCC=1C=NN(CC(=O)N(C)[C@@H1](C)C(=O)NCC2C[C@H1](O)[C@@H1](O)C2)C=1 CC=NC1=CC(CCC(=O)N2CC(O)(CN(C)C(=O)C3=NC=CC=C3C(F)F)C2)=N1 CC1=NSC=C1CC(=O)N[C@H1]2C[C@H1](CNC(=O)C3=CC=CC4=C3O[C@H1](C)[C@@H1]4C)C2 CC1=CC=C(Br)C=C1CC(=O)NCCNC(=O)CNS(=O)(=O)C2CC2 COC1=CC=C2C(=C1)C(C)(C)CN(CC3([C@H1]4CCCCN4)CC3)C2 CN1C=C(Br)C([C@H1](CC2CC2)NC(=O)NC[C@H1]3CCCC(=O)N3)=N1 CCC[C@H1](OC)C(=O)NC[C@@H1]1CN(C(=O)CCCN2C(O)=NN=C2O)CC[C@H1]1C CCCCC[C@@H1](O)CC(=O)N1CC[C@H1](C(=O)N[C@@H1](C(=O)OC)[C@H1](C)O)[C@H1](O)C1 CC1=CC=C(CC(=O)NCC[C@]2(O)CCN(C(=O)C[C@@H1]3OCCC3(C)C)C2)C=N1 COCC[C@H1](OC)C(=O)N1CCN(C(=O)C2=CC=NC=C2OC)C[C@H1]1C3CC3 COCCCC[C@@H1](NCC1=CC(C(N)=O)=NO1)C2=CC=CC=C2 COCCCOCC(=O)N1CC[C@H1](C(=O)NCC2(O)CC=CC2)[C@H1](O)C1 CC(C)(CC(=O)N1C[C@H1]2C[C@H1](NC(=O)[C@H1]3C[C@@H1]4CC[C@@H1]4C3)C[C@H1]2C1)C(F)(F)F CO[C@@H1](CNC(=O)C1=CN=C(C)N=C1C)C(=O)N[C@@](C)(CO)CSC CSC1=CC=C(NC(=O)[C@H1](C)C2CCN(CC3=CC=C([N+1](=O)[O-1])C=C3O)CC2)S1 COC[C@@]1(NC(=O)C=CC2CCC2)CCN(C(=O)CC3=CSC=N3)C1 CCC[C@@]1(C)CCCN(C(=O)C=2C=CN(CCNC(=O)[C@H1]3CCCN3C=O)C=2)C1 CC(C)[C@@H1](CCN(C)C(=O)CCN1CC[C@@H1](F)C1)NC(=O)C2=C(C#N)CCC2 CC1=CN=C(N2C[C@@H1](NC(=O)C=3C=CN(C(F)F)N=3)CC24CCCCC4)N=C1O COCC1=NC(C(=O)N[C@H1](C)CCC(=O)NCC2=NC=CN=C2C)=CO1 CSCCCC(=O)N1CCC[C@H1](N2CCN(C(=O)CCCC3=NC=CS3)CC2)C1 C#CC[C@H1](CC(=O)NCC1=CN=CN=C1)NC(=O)CN2C=C(Cl)C=N2 C[C@@]1(CC(=O)N2CCC(O)(CNC(=O)[C@@H1]3CC34CCOCC4)CC2)CC1(Cl)Cl O=C(CC1=NC=NC=C1Cl)NC[C@H1]2CCC[C@H1]2NC(=O)C3=CC(Cl)=NC=C3F CC[C@@H1](CC(=O)NCC(C)(C)OCCNC(=O)C=1N=COC=1C(C)C)OC C[C@H1](CNC(=O)[C@@H1]1CCC2=C[NH1]N=C2C1)CNC(=O)[C@H1]3C[C@H1]4[C@@H1](O)C[C@@H1]4C3 CC1=CC=CC=2[NH1]C(C(=O)N[C@@H1]3CCCN(C(=O)[C@@H1]4C[C@@H1]5C[C@@H1]5C4)[C@H1]3C)=CC1=2 CO[C@@H1]1CN(C(=NCC2CCC(SC)CC2)NCC)C13CCCC3 CCC=1N=C[NH1]C=1C(=O)N2C[C@H1](O)C[C@H1]2CNC(=O)CSC3=CC=C(O)C=C3 CC[C@H1]1CCCN(C(=O)C2=CC(C)=NC=C2C)[C@H1]1C(=O)N[C@H1]3C[C@H1]4CC[C@@H1]3O4 CSC[C@@H1](O)C(=O)NC[C@H1]1CN(C(=O)CC2=CC=C(F)C=C2Cl)C[C@H1]1O COCC(COC)C(=O)N1CC(NC(=O)C[C@H1]2CCN3C=NC=C3C2)C1 COC1=CC=CC(C2(C(=O)OCCC3=CC=C(OC(F)(F)F)C=C3)CC2)=C1OC CC[C@H1](C)[C@@H1](O)CC(=O)NC1(C(=O)N2[C@H1]3CC[C@H1]2COC3)CC(F)(F)C1 CCN(CC)C[C@H1](F)C(=O)N1CC[C@]2(CN(C(=O)C(Br)=C(C)C)CCO2)C1 CN(C)C1=CC=C(C(C)(C)CN=C2[NH1]C(=NCC(F)(F)Cl)[NH1]C=3C=C[NH1]C2=3)C=N1 CC[C@@]1(C(C)C)C[C@H1]1C(=O)NCCCCCNC(=O)CCC2=CN(C)N=C2C CP(C)(=O)C[C@@H1](C(=O)N1C[C@@H1]2C[C@H1]1CN2C(=O)C=3N=CSC=3Br)C(F)(F)F CCCCSC1=CC=C(C2=NC(C3=CC=NC(Cl)=C3)=NN2[C@@H1](C)C4CC4)C=C1 C[C@H1](CO)CCCNC(=O)[C@H1](CNC(=O)C#CC1CCCC1)CC2CC2 CCC[C@@H1]1C(=O)NCCN1C(=O)CCCCCN(C)C(=O)C2(F)CC=CC2 C#CC[C@H1](C)C(=O)NCC[C@H1]1COCCN1C(=O)C2=CC=CC3=C[NH1]N=C23 CCN1N=C(C)C=2C=C(C(=O)NCCC3(O)CN(C(=O)[C@H1](CO)C(C)C)C3)SC=21 CCN1CC[C@H1](NC(=O)[C@@H1]2CCC[C@@H1]2CNC(=O)[C@H1](O)CN3CCCC3)C1 C[C@H1](NC(C)(C)C)C(=O)N1CCC(CNC(=O)C2=CC=C(F)C=3[NH1]C=CC2=3)CC1 CN(C(=O)C1=NOC2=CC=C(Cl)C=C12)[C@@H1]3CCCN(C(=O)CC4=CCCCC4)C3 C=CCO[C@@H1](C)C(=O)N1CC[C@H1]1C(=O)NC(C)(C)CCOC CSCCNC(=O)[C@H1](C1=CC=C2SC=CC2=C1)N3CCC[C@]4(CCS(=O)(=O)C4)C3 CCS[C@H1](C(=O)N1CC[C@](C)(NC(=O)[C@H1]2CC(=O)C3=C(F)C=CC=C32)C1)C(C)C C[C@H1]1C[C@H1](NC(=O)CC2=CN=NN2C)CCN1C(=O)/C=C/COC(C)(C)C CO[C@H1]1C[C@H1](C(=O)N2CC3(CCN(C(=O)CC(C)(C)C#N)C3)C2)C[C@H1]1OC CN1CCOC2=CC=C(C(=O)N[C@H1]3C[C@H1]4C[C@H1]3CN(C(=O)[C@H1]5C[C@H1](O)C5)C4)C=C21 CSC1=CC(C)=CC=C1CN2C(CC(C)C)=NN=C2N(C)CCN3C=CC=N3 CC1=CC2=C(S1)CCN(CC3=CN(CCCC4=CC=CC=C4)N=N3)C2 CCC(CC)N(CC)C(=O)[C@@H1]1COCC[C@H1]1NC(=O)C2=C(C)CCC2 CC1(C)C[C@H1](CNC(=O)[C@@H1]2C[C@@H1]3CCC[C@H1]32)CN1C(=O)C4C[C@H1]5C[C@@H1](C4)CS5 CC1=N[NH1]C=C1C(=O)N[C@@H1]2[C@H1]3CCN(C(=O)CC4=CC=C(C#N)C=C4)C[C@H1]32 O=C(NCC1=CC=C(C2=CC=CC(Br)=C2)C=C1)C3=C[NH1]C4=CC(F)=C(F)C=C4C3=O O=C(C1=C[NH1]C2=CC(Cl)=C(Br)C=C12)N3CC[C@H1]4CN(CC=5C=C[NH1]C=5)C[C@H1]43 CCC1=NC(C)=CC(NC2CC3=NC(C(=O)NC[C@H1](C)OC)=CN3CC2)=N1 CNC1=NC(C)=CC=C1C(=O)N2CC[C@H1]3C[C@@H1](CN(C(=O)C4=CC(F)=N[NH1]4)C3)C2 CC1(C)CCC[C@@H1]1CCNC(=O)/C=C/CC2(NC(=O)[C@@H1]3CSCC(=O)N3)CCC2 COC(=O)C1=CC(C)=NC(C2CN(C(=O)[C@@H1](O)C3=CC=C4C=CC=CC4=C3)C2)N1 C[C@@H1](OCC1=CC=CC=C1)C(=O)N(CCCNC(=O)[C@H1]2CCN(C)[C@H1]2C)C3CC3 COCC1=NC=C(C(=O)NCC2=CSC(CNC(=O)[C@@H1](O)CCN(C)C)=N2)S1 CC1=CSC(Cl)=C1C(=O)N2CCC[C@@]3(C2)CN(C(=O)[C@@H1]4C[C@H1]4CC(C)C)CCO3 CC[C@H1]C(=O)NC1=CC=C(C(=O)N[C@@H1]2C[C@@H1]2CNC(=O)CC(C)(C)CC(F)F)C=C1 COC1=CC=C(F)C2=C1C[C@@H1](NC3=NC(C)=CC(=NC[C@@H1](C)CCCO)[NH1]3)C2 CC[C@@H1](OC)C(=O)N1C[C@H1](NC(=O)C2=CC=3SC(C)=NC=3[NH1]2)CC14CCOCC4 C=CC1(CC(=O)N(C)C[C@H1](CC)NC(=O)C2=CC(C)=CC=C2Br)CCC1 CCC1=CSC(CC2CCN(C(=O)C(=O)NC3=CC=C(C(C)(F)F)C=N3)CC2)=N1 O=C(C=1SC=NC=1C(F)F)N2CC3(C2)CN(C(=O)C(F)(F)C4(O)CCOCC4)C3 CCC1=CN=C(N2CC([C@H1]3CCCN(C(=O)C=4[NH1]N=NC=4C)C3)C2)N=C1 C[C@H1](CC#N)C(=O)NC/C=C/CC(=O)NCC1CCC2(CC1)CC2 O=C(CCN1C=CN=N1)NCC2=CC=C(C(=O)NC3=CC=C4C(=C3)CCO4)N=C2 C=CC1(C(=O)NC2=CSC(C)=C2)CCN(C(=O)C=CC(F)(F)F)CC1 CCC1(NC2=NC=NC(OC)=C2OC)CCN(C(=O)[C@@H1](C)C(C)(C)C)CC1 OCCCC[C@@H1](N[C@]12CCCCC[C@H1]1OCC2)C3CC3 CC[C@H1](CO)CCNC(=O)[C@@H1]1N(C(=O)C[C@H1]2CC(C)(C)CO2)CCCC1(C)C C[C@@H1](C1=CC=CC=C1F)N2C=C([C@@H1]3CCN(C(=O)C4=CC=CC(Cl)=C4)C3)N=N2 COC[C@](C)(O)CNC(=O)C=1C=COC=1CNC(=O)CC2=CC=CO2 CC=1C=C(C(=O)NC[C@@H1]2CC[C@@H1]2NC(=O)C=CC(=O)NC3CC3)C4=N[NH1]C=C4C=1 CC1=CC=CC(C(=O)N2CC[C@]2(C)CC(=O)N(C)[C@@H1]3COC(C)(C)C3)=C1C O=C(COC1=CC=C2N=C(CO)[NH1]C2=C1)N3CCOC[C@H1](N4C=CC=N4)C3 C#CCOC1=NC=CC=C1C(=O)N2C[C@@H1](NC(=O)[C@@H1]3C[C@H1]3OCC)[C@H1](C)C2 CCCOC1=CC=CC(C(=O)N2CCOC[C@@H1](CNC(=O)[C@@H1]3CCC(=O)N3)C2)=C1 CNC(=O)[C@@H1]1CCN(C(=O)[C@H1](CO)NC(=O)CCC2=NC=NN2C)[C@@H1]1C O=C(N[C@@H1](C(=O)N[C@H1]1CCC12CCCC2)C3CCCC3)C=4SC=CC=4CO O=C(N1C[C@H1]2COC[C@@H1](C1)N2C(=O)CCBr)C3=CON=C3C4CCC4 CO[C@@H1]1CN(C(=O)C2C(C)(C)C2(C)C)C[C@@H1]1NC(=O)/C=C/CCC=C(C)C CC(C)C[C@H1](CNC(=O)C=CC=1C=C[NH1]N=1)NC(=O)CC[C@@H1]2CCCN(C)C2 COCCN(C(=O)CN1C=C(Br)C(C2CC2)=N1)[C@@H1](C)C3=CC=C(C)O3 C[C@H1](CC1CN(C(=O)[C@]23CCCCN2CCC3)C1)NC(=O)C45CC(C)(C4)C5 CC=1OC(CNC(=O)CCCC2CC2)=NC=1C(=O)N3CCC[C@H1](N=[N+1]=[N-1])C3 C[C@@]1(CNC(=O)[C@]23CO[C@H1](C2)[C@H1](NC(=O)CN4C=C(Cl)C=N4)C3C)C=CCC1 O=C(C[C@H1]1CCN1C(=O)C2=CC=C(CO)O2)N[C@@H1]3CCOC34CCCC4 CC1=NC=C(CN=C2C=CN=C(NC3CC4=CC=CC=C4C3)[NH1]2)S1 C[C@@H1](CCNC(=O)[C@H1](C)N(C)CC(F)(F)F)N(C)C1=CC=NC(C2CC2)=N1 CN(C(=O)C[C@H1]1C[C@H1]1CNC(=O)C2=CC=C(CO)O2)[C@@H1](CCO)C(F)F OCC(F)(F)CN1CCN(CC2=CC=C(Br)C(OC(F)(F)F)=C2)CC1 CC1=NN(C)C(CN(C)CC[C@H1](C)O)=C1S(N)(=O)=O CC1=CC(C(=O)N2C[C@@H1](O)[C@H1](NC(=O)CN3CCCC[C@H1](CO)C3=O)C2)=C(C)O1 C[C@@H1]1CC[C@@H1](CC(=O)N2CC(NC(=O)CC=3N=NN(C(C)(C)C)N=3)C2)O1 O=C(NC1[C@H1]CCCN(C(=O)CC2[C@H1]CC3=CC=CC=C32)C1)C=4C=CSC=4 O=C(C[C@@]12CCC[C@@H1]1C2)N[C@@H1](CO)C(=O)NCC3=CC=CC(F)=C3F CCOCC(C)(C)C(=O)NCC1=CC(O)=NC(CNC(=O)[C@@H1]2CCS(=O)(=O)C2)=N1 CC(C)N1CC(C(=O)N2CC3(CC3)C[C@H1]2C(=O)NC[C@@H1]4CCOC4=O)C1 C[C@H1](OC1COC1)C(=O)N2C[C@@H1](NC(=O)C=CC3=CC=CC=C3F)CC4(CC4)C2 CC1=CC(C(=O)NC[C@]2(F)C[C@@H1](NC(=O)C3CC(=C4CCC4)C3)C2)=C(O)N=C1C CN(C)C(=O)C(C)(C)C(=O)NC1CCC2(CC1)CN(C(=O)[C@@]3(C)CCCOC3)C2 C[C@H1]([C@@H1](C)S(C)(=O)=O)N(C)[C@@H1](C(=O)NC(C)(C)C)C=1C=NN(CCF)C=1 CC1=NN=C(CC(=O)N[C@H1](C2=CC=CC=C2)[C@@H1](C)NC(=O)C(C)(C)C(C)C)S1 CN(C)C(=O)C#CC(=O)N1CCC[C@@H1](NC(=O)C2OCCCO2)[C@H1](F)C1 C#CCCC(=O)NC[C@@]1(OC)CCN(C(=O)C(=O)C2=CC=C(OC(C)C)C=C2)C1 O=C(CC1=CC=C2C(=C1)CCOC2)NC3CC4(C3)CN(C(=O)C#CC5CC5)C4 CNC(=O)NCCC(=O)N[C@H1](C)[C@H1]1CCN(C(=O)CCNC2=CC=C(C)C=C2)C1 O=C(N[C@H1]1C[C@H1]2C[C@H1]1CN2C(=O)C3=N[NH1]C=C3C(F)(F)F)C4=CC5=C(S4)CCC5 C=C(C)COCC(=O)N[C@H1]1CN(C(=O)CCC2=CC=NC=C2)CC[C@H1]1CO CC1(NC(=O)C2=CC(N)=C(C(F)F)S2)CCC(NC(=O)C3(CC4CC4)CC3)CC1 CCCN(CC(=O)N1CCC[C@@H1](CC)C1)C(=O)C(=O)C2CCCC2 CC1CC(N=C2[NH1]C3=C(C(=NCC[C@H1]4OCCCC4(C)C)[NH1]2)SCC3)C1 C#CC[C@@H1](C(=O)NC/C=C/CNC(=O)COCC1CC1)C2CC2 CC=1C=C(C)N(CC(=O)N(C)C[C@@H1](C)NC(=O)[C@H1](C#N)C2CC2)C(=O)N=1 C[C@H1](C(=O)O[C@@H1]1CCNC1=O)N2CCN(C3=NC=CN=N3)CC2 COCCNC(=O)C(=O)N1CCC2(CC1)C[C@H1]2NC(=O)C3=CC=C([S@@](C)=O)C=C3 CC[C@H1](C)C(=O)C(=O)N[C@H1]1CC[C@H1](NC(=O)C2=NO[C@H1](C)C2)C1 CCC[C@H1](C)C=1N=C(C2=CC(Cl)=CC=C2F)N([C@H1]3CCS(=O)(=O)C3)N=1 CC1=NO[C@](C)(C(=O)N2C[C@@H1]3C[C@H1]2[C@@H1]3CNC(=O)C4=CC(C)=NC(C)=C4C)C1 C[Si]1(C)CCCCN(C(=O)[C@@H1]2[C@H1]3C[C@H1]3CN2C(=O)C=CBr)C1 CN1N=C(O)C=C1C(=O)N2CC[C@@H1](NC(=O)C=3C=COC=3Cl)C(C)(C)C2 CC(C)=C(C)C(=O)N1C[C@@H1]2CCC[C@H1](NC(=O)C=3C=CN(CC(C)C)N=3)[C@H1]2C1 C=C(C)CC(=O)NC[C@@H1]1CCN(C(=O)[C@H1](C)OC(C)(C)C)C[C@@H1]1C CC1(C)C[C@H1](NC(=O)C=2C=COC=2Br)CN1C(=O)[C@@H1]3CNC(=O)N3 O=C(NC1(C2=CN(CC3=CC=CC=N3)N=N2)CC4(CCCC4)C1)C5=CCCCC5 COC(=O)C1=CC=C(C(=O)N2C[C@@H1]3C[C@]3(CNC(=O)[C@H1]4C[C@](F)(CO)C4)C2)C=N1 C=CC[C@@H1](CC)C(=O)NCC1(C2(O)CN(C(=O)CC3=NC([N+1](=O)[O-1])=N[NH1]3)C2)CC1 COC(=O)C[C@@H1](C)C(=O)NC(C)(C)[C@H1]1CCN(C(=O)CCC(C)(F)F)C1 CC1=CC=CC(C(=O)N[C@H1](CC(C)C)C(=O)N[C@@H1](C)C=2[NH1]C(C)=NC=2C)=C1 COC1=CC(N2CCO[C@H1](CC(=O)NCCN3CCCCC3=O)C2)=NC=N1 CCO[C@H1](C(=O)N1CC[C@](COC)(NC(=O)COC)C1)C2CC2 C[C@H1](CNC(=O)C1=CN=C2C=CC(Cl)=CN12)NC(=O)C3=CC=CC([N+1](=O)[O-1])=C3N COC(=O)N[C@@H1](C)C(=O)N1CC[C@H1](NC(=O)C2(C3(O)CCOCC3)CC2)[C@H1](C)C1 CC1=CC=NN1[C@H1](C)C(=O)NC[C@]2(C)CN(C(=O)CN3N=CC=CC3=O)CCO2 CC1=NC=NC(C(=O)NCCCN(CCO)C(=O)CC2=CC=NN2C)=C1C COCC1=NC=C(CNC(=O)N2C[C@@H1](C)N3N=C(C)C=C3[C@H1]2C)[NH1]1 C[C@H1]1CC[C@@H1](C(=O)NC2(CNC(=O)C3=CC=C(C4CC(F)(F)C4)C=C3)CC2)C1 CC=1C=NOC=1C(=O)N2CCC[C@H1]2C(C)(C)NC(=O)C=CC3=CC=C(C(F)F)O3 O=C(NCCC1=CCN(C(=O)[C@H1](F)C2CCCCCC2)CC1)C3=CN=C(Cl)[NH1]3 CC1=NC=CC=C1CC(=O)N2CC[C@H1](C(=O)NC3CCN(C)CC3)C24CCC4 CC[C@H1](C)[C@@H1](CC(=O)N1[C@H1]2COC[C@H1]1C2)NC(=O)C3=CC=C(C(C)C)O3 CCC1=NC(C(=O)NCCOCCN(C)C(=O)CC2=CC=NN2C)=CO1 CC[C@H1](O)C(=O)N1C[C@H1]2C[C@H1]1CCN2C(=O)C3=CN=C4C=CC=CC4=C3 C[C@H1](NC(=O)[C@@H1]1C[C@H1]2C[C@H1](N)C[C@H1]2C1)C3=NOC(CC4=CC=CC=C4)=N3 C#CC[C@@H1](O)C(=O)NC1(C(=O)N2CC(C)(C)[C@H1]2C3CC3)CSC1 CN(C[C@@H1]1COCCN1C(=O)C=2SN=NC=2C3CC3)C(=O)C[C@H1]4CC(=O)NC4=O CC1=CC=CC(C(=O)N2CCC[C@H1]3CN(C(=O)[C@H1](O)C=4C=NN(C)C=4)C[C@H1]32)=C1C CSCC1=CN(C[C@H1]2CC[C@H1](CNC(=O)C3(C(C)C)CC3)CC2)N=N1 CCN(CCNC(=O)C1=CC(N)=CC=C1SC)C(=O)C2=C[NH1]C(=O)C3=CC=NN23 O=C(C1=NC=CC=C1Cl)N2CC[C@]3(C(=O)NC4=CN=CC(F)=C4)C[C@@H1]3C2 C[C@H1]1CN(CC2=CC=C(F)C=C2Cl)CCCN1C3=NC=C4[NH1]C=CC4=N3 C#CCCCC(=O)NC[C@@H1]1CCC[C@H1](NC(=O)C[C@@H1]2C[C@H1]2CC3=CC=CC=C3)C1 NC(=O)C1(NC(=O)C[C@@H1]2C[C@@H1](O)CN2C(=O)CN3N=CC=N3)CC1 C[C@H1](CO)N(C)C(=O)CC1(NC(=O)[C@@H1]2CC(=O)OC2(C)C)CCCCC1 O=S(=O)(NCC1CC1)C2=CC=CC(=NC[C@@H1]3C=CCCC3)[NH1]2 CC1=CC(C(=O)N2CC3(CC(NC(=O)CSCCC4=CC=CC=C4)C3)C2)=CN1C COC1(C(N)=O)CN(C(=O)[C@@H1]2CN(C(=O)C[C@H1]3CC(C)=NO3)CC24CC4)C1 CCN1C=CC(CC(=O)N2CCSC[C@H1]2C(=O)N(C)CC3=NC=CS3)=N1 CCCC1=NC(C(=O)NC2(C(=O)N(C)CCC[C@@H1](C)O)CC(F)C2)=CO1 COC[C@H1](O)C(=O)N(C)CCN(C)CC(=O)N[C@@H1](C)C1=CC=C(Cl)C=C1 CC=CCNC(=O)CN1CCN(C(=O)C2CC(C)(CC)C2)CC1 CCC=1OC=C(C)C=1C(=O)NC[C@H1]2COC[C@H1]2NC(=O)[C@H1](O)CC3=CC=CC=N3 COC=1C=C(C(=O)N2C[C@H1]3CC[C@]3(CCNC(=O)C4=CC=C(C)S4)C2)[NH1]N=1 C=CCN1N=NN=C1[C@H1](NCC(=O)N=C2C=C[NH1]C=C2)[C@H1](C)CC CC1=NC=C(NC(=O)[C@@H1]2C[C@H1]3C[C@@H1]3N2CC4=CC=C(F)C(C5=CC=CC(F)=C5)=C4)S1 CC1=CN=CC(OCC(=O)N2CC(CCC3=CN(CC4=CC=NO4)N=N3)C2)=N1 CC1=CC(C(=O)N2CCSC[C@H1]2CCNC(=O)C3=COC4=C(C)C=CC=C34)=CS1 CO[C@H1](C)C(=O)N1CCC(C)(CNC(=O)C2C[C@H1]3CCC[C@H1](C2)C3)CC1 C=CCC1=CC=CC=C1C(=O)N2C[C@@H1](CO)C(C)(C)C2 CC(C)(C)OC(=O)N1C[C@H1](C(C)(C)C)[C@@H1](NC2=NC=C(F)C=N2)C1 C#CCCC(=O)NC[C@@H1]1N(C(=O)CC=2C=C(C)N(C)N=2)CCC1(C)C CN(C)C1=NN=C(CN[C@]2(C3=NN=NN3C4CC(F)(F)C4)CCCC[C@H1]2CO)O1 C#CC1=CC=C(CNC(C)(C)C2=CC=CC(C(F)(F)F)=C2)C(O)=C1 C=CCC[C@@H1](NC(=O)C(C)(C)CNC(=O)[C@@H1](CCOC)OC)C1CC1 CC(C)(CNC(=O)CC1=CSC(C2=CN=CC=N2)=N1)NC(=O)[C@@H1](O)CC(N)=O CC1=NC(C(=O)N(C)[C@@H1]2CCCC[C@H1]2N(C)C(=O)[C@H1]3C[C@@H1]3C)=CC=C1Br CC=1N=NN(C)C=1NC(=O)NCC(F)(F)C2=CC=C(Br)C=C2Cl CC1=NOC(N)=C1C(=O)N2CC[C@@H1](CC(=O)N(C)CCN3CCCCC3)C2 C[C@H1](C#N)CCC(=O)N[C@@H1]1CC[C@H1](CNC(=O)COCCF)C1 CC=1C=C(C)N([C@@H1](C)CNC(=O)N[C@H1]2CCN(CP(C)(C)=O)C2)N=1 CC1=CC(CNS(=O)(=O)C2=CC=C(NCC3=C(C)C=CC=C3Cl)C=C2Cl)=CO1 CCC[C@@H1]1CCCN(C(=O)CN(C)C(=O)[C@]2(C)CCO[C@@H1](C)C2)CC1 CCC[C@@H1](NC(=O)C1=NC=CC=N1)C2=CN(C3=CC(Cl)=CC=C3C)N=N2 CN1C=CN=C1CC(=O)NC[C@H1]2CCCN(C(=O)C3=C(F)C=CC=C3Cl)C2 CC1=CC=C(C(=O)NC[C@H1]2C[C@]3(CCN(C4=NN=C(O)S4)C3)CO2)C=N1 CCOC1=NC=C(C(=O)N2CCC(C)(C)[C@@H1]2CNC(=O)C=3C=COC=3Cl)C=C1Cl CN1C=CC(C2=CN=C3N=C(Cl)C=CC3=C2)=CC1=O CC(=O)N1CCC[C@H1]1CC(=O)N[C@H1]2CCN(C(=O)C3=CC(C)=C(C)O3)C24CC4 C[C@@H1]1C[C@@H1](NC(=O)C2=CN=C3C(F)=CC=CN23)CCN1C(=O)C[C@@H1]4CCC[C@H1]4O C=CCN1C=CC=C1C(=O)NCC[C@H1]2CC(F)(F)CN2C(=O)CC3OCCCO3 C#C[C@@H1]1CN(C(=O)[C@H1]2CC[C@H1](CNC(=O)C[C@H1]3CCC(C)(C)O3)CC2)C[C@H1]1O CCC1=NOC(C)=C1C(=O)N[C@H1](CNC(=O)C2=CN=CC(Cl)=C2)[C@H1](C)C(C)C CN1CC(=O)N(CC(=O)NC[C@H1]2C[C@@H1](NC(=O)C3=CC=CC(F)=N3)C2)C1=O CC[C@H1](C)N1N=C(CC(C)(C)CO)N=C1C=2C=C3N=CC=CN3N=2 CN1N=CC(C2CCC2)=C1C(=O)N3CCN(C(=O)C4(N5C=CN=N5)CC4)[C@@H1](CO)C3 O=C(NC[C@@H1]1CCN1C(=O)C=2C=C3N(N=2)CCCC3)C4=CC(O)=NO4 CC(C)N1CCN(C(=O)[C@@](NC(=O)CC2=NN(C)C(=O)C2)C3CSC3)CC1 CN1[C@H1](C(N)=O)CC[C@@H1]1C(=O)N2C[C@@H1]3CCN(C(=O)C4=NOCC4)C[C@H1]32 CC[C@H1](CNC(=O)CC1=CC=CC=C1OC)NC(=O)C2=CC=3OC=CC=3[NH1]2 CCC1=C(C(=O)N(C)[C@H1](C)CCNC(=O)C2=CC(O)=CC(C(F)(F)F)=C2)SC=N1 CN(C)S(=O)(=O)N1CCC2(CC1)C[C@@H1]2C(=O)NCC(C)(C)NC[C@H1](O)CO CCN1CCC[C@@H1]1C(=O)N(C)CCOCCC(=O)NC[C@H1]2OC(=O)NC2(C)C C[C@@H1](NC(=O)[C@H1]1CC[C@@H1](NC(=O)C2=COC(Cl)=N2)CC1)C3=CC=C(F)C(F)=C3 CCOC(=O)[C@@H1](C)CNC(=O)C(C)(C)[C@H1](C)NC(=O)C1=CCC(C)(C)CC1 CC(C)SCC(=O)N1CC[C@H1](CCNC(=O)C2=C([N+1](=O)[O-1])C3=CC=CC=C3C=C2)C1 CC(C)(C)OC(=O)N[C@]1(C)CCCC[C@H1]1C(=O)N[C@H1]2C[C@H1](COC3=CC=CC=C3)C2 CC1CCN(C(=O)C(=O)NC[C@]2(F)C[C@@H1](CNC(=O)CC=3C=C[NH1]C=3)C2)CC1 CCC=CC(=O)N[C@@H1](C)C[C@@H1](C)NC(=O)C1=CN=C(Cl)C=C1N CO[C@H1](C1NC(=O)C(=O)CC1)CN2C=C(C3=CC=C(N)C=N3)N=N2 CC1=NN2C=CC=NC2=C1C(=O)NC[C@H1](NC(=O)[C@@]3(C)CCC[C@@H1]3C)C(C)C COC1=CC=C(C(=NC(=O)N2NC(=O)[C@@H1](C)OC3=CC=CC=C32)C4CC4)C=C1 CC(C)C1=CC=CC(C(=O)N2CCOC[C@@H1]2CNC(=O)CCNS(C)(=O)=O)=N1 C[C@]1(NC(=O)[C@@H1](F)C2CCC2)C[C@H1](NC(=O)C3=CC=NC=N3)C1 O=C(C1=CC=CC(C2(CO)CC2)=C1)N3CCN(C(=O)CO)[C@H1]4CCC[C@H1]43 C=CC(C)(C)C(=O)NCCN(CC)C(=O)C(C)(C)C1=CC=C([N+1](=O)[O-1])C=C1F CC(C)[C@@H1](C)CN(C)CCC(=O)N[C@@H1]1CCN(C(=O)CCC(F)(F)F)CC1(C)C CN1C=C(C(=O)C=CC(=O)N2[C@H1]3CC[C@@H1]2C[C@H1](NC(=O)[C@H1](F)C(C)(C)O)C3)C=N1 CN=C1[NH1]C(C(=O)N2CCC(CCNC(=O)C[C@@H1](C)COC)CC2)=CS1 CCCN(CCNC(=O)C1=CC=CC(CC)=C1F)C(=O)CO[C@@H1]2CCOC2 C=CC[C@]1(C(=O)N(C)CCCN2CCCC2)CCCN1C(=O)CN3C=C(C)C=N3 CCC1=CC=C(NC(=O)C2=CN=CC(CNC(=O)C=3C=CC(=N)[NH1]C=3)=C2)C=C1 COCCC[C@@H1](C)C(=O)N1CC[C@H1](N(C)C(=O)C2=COC3=CC(OC)=CC=C23)C1 CC(=CC1=CC=CO1)C(=O)NC[C@H1]2C[C@](F)(CNC(=O)[C@@H1]3C[C@@]34CCCOC4)C2 CC1=CC=CC(C)=C1OCCC(=O)N2CCN(C(=O)C=CI)C3(CC3)C2 CNC1=CC=CC(C(=O)NCCOC2CN(C(=O)[C@]3(C)C[C@H1]3C)C2)=N1 CO[C@@H1](CC1CC1)C(=O)N[C@@H1]2CCCN(C(=O)C=3SC4=CC=CN=C4C=3Cl)C2 COC=1SC=CC=1C(=O)N2C[C@H1]3[C@H1](NC(=O)CC[C@H1]4CCC(=O)N4)[C@H1]3C2 CC(C)OCCC(=O)NC12CC(CO)(C1)OC23CN(C(=O)[C@@H1]4C[C@H1](C)O[C@@H1]4C)C3 COC1=CC=CC(CN2[C@H1]3CC[C@@H1]2C[C@H1](NC(=O)C4CC(C)(C)C4)C3)=C1OC CO[C@@H1]1C[C@H1](CNC(=O)C2=CC=CC=C2)N(C(=O)[C@@H1]3CCCN3C(C)C)C1 CCOC=CC(=O)N[C@@H1]1CCN(C(=O)C2=CN=C(C3CC3)N=C2C)[C@H1]1C4CC4 C=CC1(CC(=O)NC[C@@]23C[C@@H1]2CN(C(=O)C4=NC=C5N4CCCC5)C3)CCC1 CCCCO[C@@H1](C)C(=O)N1C[C@@H1](O)[C@H1](N2C=C(C3=CC=CC(F)=C3)N=N2)C1 C=CCC[C@@H1](NC(=O)C1=COC(OCC)=N1)C(=O)NCC2=NC(C)=C(C)O2 CC[C@@H1]1CN(C(=O)CC2=CN=CC(C)=C2)C[C@@H1]1NC(=O)C3(F)CCCC3 CC=1C=CN2C=NC(C(=O)N3C[C@@H1]4C[C@H1]3[C@@H1]4NC(=O)C5=CC=C(O)N=N5)=C2C=1 CCC1=CC=C(C(=O)NC[C@]2(NC(=O)C=3C=C4N(N=3)CCCO4)CCOC2)N=C1 CCO[C@@H1]1C[C@@H1](NC(=O)[C@](C)(O)C2=CC=C(Cl)C=C2)[C@]13CCCO3 CN(C[C@@H1]1C[C@H1](F)CN1C(=O)C2=CC=C(C3CC3)C=C2)C(=O)C4=CC=CC=C4F O=C(C1=CN=NC=C1O)N2C[C@@H1]3CCC[C@H1](C2)CN3C(=O)C4=CC=CC(Cl)=C4 CC1=C(C(=O)NC[C@H1]2C[C@H1](CN3C=CC=N3)C[C@H1]2O)N=NN1[C@@H1]4CCOC4 C[C@@H1](CNC(=O)C1CN(C2CCC2)C1)NC(=O)[C@@]3(C)COC(=O)C3 COC1=CC=C(CC(=O)N2CC[C@@H1](NC(=O)C(=O)N=S(C)(C)=O)[C@H1](O)C2)C(F)=C1 CC=1N=COC=1C(=O)N(C)CCN(C)C(=O)C2=CC=C(C3=CC=CC=C3)C=N2 CN(CCC(=O)NC1(CCO)CCC1)C(=O)[C@H1]2C3C[C@@H1]4C2[C@@H1]4C3 C[C@@](CO)(CNC(=O)CC1=CSC(C=2C=CSC=2)=N1)NC(=O)C3=COC(C#N)=C3 CC1=NC2=C(N1C)CCN(C(=O)CC3(NC(=O)C4=CSN=N4)CCCCC3)C2 COC1=CC=C(C2(O)CN(NC(=O)N[C@@H1]3CC4=CC=CC=C4NC3)C2)C=C1 CC1=CC=NC=C1C(=O)N[C@@]23CCCC[C@@H1]2CN(C(=O)C4CC(C(C)C)C4)C3 C=C1CC(C)(C(=O)NCC2=CC(C(=O)N3CCC(C(C)(C)C)CC3)=NO2)C1 O=C(CN1C=NN=C1O)NC[C@@H1](O)CNC(=O)C2=C[NH1]N=C2C3CCC3 O=C(NCCCCCCNC(=O)C1CCC1)C2=CC=C3N=C(S)OC3=C2 CC(=CC1=CN=C[NH1]1)C(=O)NC[C@H1](NC(=O)[C@@H1](C)N2C=C(C)C=N2)C3CC3 CCCCN(CCO)C(=O)C1(C2CC2)CN(C(=O)CC3CC4(CC4)C3)C1 CN(CCN(C)C(=O)[C@@H1](OC1=CC=CC=C1)C(C)(C)O)C(=O)C[C@H1]2COCCO2 CC(C)(C(=O)NC[C@@H1]1CCC[C@H1]1NC(=O)[C@@H1]2CCCC3=N[NH1]C=C32)C4=CC=NS4 CC1=COC(C)=C1CNC(=O)[C@@]2(N=[N+1]=[N-1])CCN(C(=O)CN3N=CC=N3)C2 CC[C@H1](C)N1N=NN=C1[C@H1](NCC2=C(C)C=NN2C)C3=CC=C(Br)C(C)=C3 CNC1=CC=C(C(=O)N[C@H1]2[C@@H1](CNC(=O)C=3C=C(CO)[NH1]N=3)CCC2(C)C)N=C1 CC1=NNC(=O)[C@H1]1CC(=O)N[C@@H1]2C[C@H1]3CC[C@@H1]2C[C@H1]3NC(=O)CC4OCCO4 CCC(=O)N1CC[C@H1](C(=O)N2C[C@H1]3CN(C(=O)C=4C=CC(=N)[NH1]C=4)C[C@H1]3C2)C1 C#CC[C@@H1]1CN(C(=O)[C@@H1]2CN(C(=O)/C=C/C3=CC=C(C)C=C3)C[C@H1]2F)CCO1 O=C(NCCC1(CNC(=O)[C@H1]2CCC[C@@H1]2O)CC1)C=3SC4=CC=CC=C4C=3Cl CN1N=C(C(=O)NC2C[C@H1]3CCN(C(=O)CCS(N)(=O)=O)C[C@@H1]3C2)C=C1O C[C@H1](CN(C)C(=O)CNC(=O)CCC1CCCC1)NC(=O)[C@H1]2C[C@@H1](C#N)C2 O=C(CCC1CCOCC1)NCCCNC(=O)C2=CC=C(F)C(Br)=C2 O=C1C[C@H1]2[C@H1](CCCN2C[C@H1](O)CC3=CC=CC=C3)N1 O=C(CN1C[C@H1]2C[C@@H1]2C1)N3CCN(C(=O)C4(O)CCC4)C5(CCC5)C3 CN1C=C(C(=O)NC2(C)CCC(C(C)(C)C)CC2)C(CC3=CC=CC=C3)=N1 C[C@@H1]1O[C@H1]2CC[C@@]1(C(=O)NC[C@H1](C(=O)NC[C@@H1]3CCC(=O)N[C@H1]3C)N(C)C)C2 CCC1=CON=C1C(=O)N2CCN(C(=O)C(F)(F)[C@H1](O)CC)C[C@@H1]2CS(C)(=O)=O C=CC1(C(=O)N[C@@H1]2C[C@H1]3CC[C@H1]2N(C(=O)C(F)(F)[C@H1](O)C(C)C)C3)CCC1 CC1=N[NH1]C=C1CC(=O)N[C@H1](CO)C(=O)N2CC[C@H1](N(C)C)[C@H1](C)C2 CN(CC(C)(C)NC(=O)C1=CC=C(F)C(F)=C1F)C(=O)C[C@@]2(C)CCCO2 CC(=O)NC1=CC=C(C(=O)N[C@H1]2C[C@](C)(NC(=O)[C@H1]3CCCC[C@H1]3F)C2)C=C1F CCN(CCNC(=O)[C@@H1]1C[C@H1]1C)C(=O)C2=CC=C(C3=CC=CC=N3)S2 COCC[C@]1(NC(=O)C23CC(F)(C2)C3)CCN(C(=O)C[C@@H1](C)OC)C1 CO[C@@H1](C(=O)N1CCC(C2(NC(=O)[C@H1](CO)C(F)(F)F)CC2)CC1)C3CCCC3 CCC1C[C@@H1]2CC[C@H1](C1)N2C(=O)C3CC(CCNC(=O)[C@H1]4CCC[C@H1]4C)C3 C=C[C@@H1](CCC)CC(=O)N(C)C1CC(NC(=O)C2=CN(C)N=C2C(F)(F)F)C1 CC(C)(C(N)=O)C(=O)N1CC[C@@]2(CCN(C(=O)[C@@H1]3CNC(=O)C4=CC=NN43)C2)C1 CSC(C)(C)C(=O)N1CC[C@@](C)(CNC(=O)C2=CC=C(NC(C)=O)C=C2F)C1 C[C@H1]1CN(C(=O)C2=CN=C(Cl)S2)C[C@H1]1NC(=O)C3=CN=C4OC=CC4=C3 O=C(NC[C@@H1]1CN(C(=O)CSC2CC2)[C@H1]3C[C@@H1]31)C4=CN5C=CC=CC5=N4 C#CC[C@H1](CC(=O)OC)NC(=O)[C@H1](NC(=O)C=1N=CN(C(C)C)N=1)C2(O)CCC2 CCN1C=C(C(=O)NC[C@@H1]2C[C@H1]2CNC(=O)[C@@H1]3C[C@@H1]3CF)C4=CC=CC=C41 CCC=1C=C(C(=O)N(C)C2CN(C(=O)[C@H1]3CN4CCC[C@H1]3CC4)C2)OC=1CC O=S(=O)(CC1=CC=C2C(=C1)CCC2)N[C@@H1]3CCC[C@@H1]3C4=CC=CC=C4 CCC(CC)CC(=O)N[C@@H1]1C[C@H1](O)[C@H1]1CC(=O)NCC2(O)CSC2 C=C(C)COCC(=O)N1CC[C@@H1](N(C)C(=O)C2CC(S(C)(=O)=O)C2)C1 CC[C@](C)(C#N)C(=O)N[C@H1](C)CN(C)C(=O)[C@@H1](C)CC1CCC1 CC1=CC(C)=CC(C(=O)NC[C@H1]2C=C[C@@H1](NC(=O)C(C)(C)N3C=NN=N3)C2)=C1 C[C@H1]1CCN(C(=O)CCC2=CC=C[NH1]2)CCN1C(=O)[C@H1](C)CC3=CC=C(Cl)C=C3 CC(=O)C1=CC=C(NC2CN(CCNC(=O)[C@]34CC[C@@H1]3C4)C2)C([N+1](=O)[O-1])=C1 CN(CCC1=NC=CS1)C(=O)[C@H1](NC(=O)C=CC=2C=COC=2)C3=CC=NN3C CC1=CC=C([C@@H1](CNC(=O)C2=CC(C)=C(C)O2)NC(=O)CS(C)(=O)=O)C=C1 O=C(NC[C@@H1]1CCCN(C(=O)[C@H1]2CCCC[C@@H1]2O)C1)C3=C[NH1]N=C3C4CCCC4 CCCNC(=O)CCCC(=O)NCCN(CC)C(=O)C[C@H1](OCC)C(C)C CCCN1CC[C@@H1](NC(=O)C2=C(OC)C=CC=C2OC(F)(F)F)C1 CC1=CC=C(C(=O)N[C@H1](CNC(=O)C2=CN=CC(OC(F)F)=C2)[C@@H1]3CCOC3)[NH1]1 CC[C@H1](C)[C@@H1](OC)C(=O)N1CCC(CO)(NC(=O)CCC(N)=O)CC1 O=C(NC[C@H1]1CC=CCC1)[C@H1]2[C@H1]3CCC[C@H1]3CN2C(=O)CCN4CCOC4=O O=C(NCCN1C=NN=C1)[C@@H1]2CCN2C(=O)CN3N=CN=N3 C[C@]1(CC(=O)NC2CSC2)CCN(C(=O)C3CC4=CC=CC=C4C3)C1 CCN1C=C(C(=O)NCC(=O)N2CC(C#N)(COC)C2)C=N1 CC1=NC=CN1CCC(=O)NC[C@@H1](C)C2CCN(C(=O)[C@H1]3CC4CC3C4)CC2 COCC[C@H1](CNC(=O)CC=1C=CN(C)N=1)NC(=O)C=2OC=C3C=2CCC3 CP(C)(=O)CNC(=O)C1=CC=CN=C1CNC(=O)C2C[C@@H1]3C[C@H1]3C2 COC(=O)CNC(=O)CC(C)(C)N(C)C(=O)C1=CSC(Cl)=N1 C[C@H1](C(=O)NC1(CNC(=O)C2=CC=CC(F)=C2Cl)CCCCC1)C(F)(F)C(F)F CC1(C)C[C@H1](CC(=O)N2CC(N3CCN(C(=O)C=CCF)CC3)C2)CCO1 CC=CC[C@@H1](CO)NC(=O)COC1(C)CN(C(=O)C2=C(Cl)CC2)C1 C#CCCCC(=O)NC[C@H1]1CN(C(=O)C2=CC(=O)N(C)C=N2)C[C@@H1]1C(F)(F)F CCCCC[C@@H1](O)C(=O)N[C@@H1]1CC12CCN(C(=O)CCC3=CC=C(C)C=C3)CC2 C=C(C)CNC(=O)[C@@H1](CC1=CC=CC=C1Br)NC(=O)[C@@H1]2CNC(=O)N2 CC[C@@H1](CCC1=CC=CC=C1)C(=O)N(C)[C@@H1](C)CCNC(=O)C2=COC(OC)=N2 CC1=NC(N2CCN(C(=O)C3=CSC(O)=N3)C[C@@H1](O)C2)=CC=C1C#N CC1=NC=C(C(=O)NCCNC(=O)[C@@H1]2C[C@H1](O)CN2C(N)=O)C=C1CC(C)C CC(C)N(CCNC1=NC=C(S(=O)(=O)N2CC[C@H1]3C[C@@H1]32)C=C1Cl)C4CC4 CSCC[C@@H1](O)C(=O)N[C@@H1]1CN(C(=O)CC(=O)N(C)C)C[C@H1]1CC2CC2 CC(C)[C@H1](C)C(=O)N(C)[C@@H1]1CN(C(=O)CN2C=CN=C2C(C)C)C[C@H1]1O CC(C)OCC(=O)N1CCC(C)(C(=O)N[C@H1]2CNC(=O)C2)CC1 C=CC[C@@H1](CNC(=O)[C@H1](O)CC(C)C)C(=O)NCCC=1N=C(C)OC=1C CCCCSCC(=O)N(CCC)[C@H1]1CCN(C(=O)C=2C(C)=NN(C)C=2C)C1 CCN(CCNC(=O)C(C)(C)CCF)C(=O)C1=CC(C)=CC(O)=C1 CCC(F)(F)CC(=O)NC[C@H1](C)[C@@]1(O)CCN(C(=O)C(C)(C)OC)C1 CCCCCCOCC(=O)N(C)C[C@@H1]1C[C@H1](F)CN1C(=O)C2=COC3=C2COC3 CCC(C)(C)[C@H1](O)C(=O)N1C[C@@H1](C)O[C@H1](CCNC(=O)C=C(C)C2=CC=CS2)C1 COCC12CC(CNC(=O)[C@H1](O)C(F)F)(CN1C(=O)C[C@@H1]3CC[C@@H1](C)CO3)C2 C=CC[C@@H1](CO)NC(=O)[C@H1](CO)NC(=O)C[C@@H1]1CCCNC1=O COC1(C(=O)NC[C@H1]2CCCN(C(=O)C3=CC=CC=C3)CC2)CCCCC1 CC1=C(C=CC(=O)N2C[C@@H1](NC(=O)CC[C@H1](O)C(C)(C)C)[C@H1](C)C2)C=NN1C COCC[C@@H1]1C[C@H1]1C(=O)NCCC2(CNC(=O)CC=3N=CN4C=3COCC4)CC2 CC1=NC=CC=C1CC(=O)N[C@@H1]2CC23CC(NC(=O)[C@H1](C)OCC(F)(F)F)C3 CC1=CC(C2CC2)=CC=C1CNC3(CC4CC4)CCC3 C[C@H1]1CN(C(=O)CNC2=CC=CC(Cl)=C2)C[C@H1]1NC(=O)[C@H1](O)C3=CC=C(F)C=C3 CCCC1(O)CN(C(=O)CCNC(=O)CC2=CC=CC(C#N)=C2)C1 CC[C@@H1](NC(=O)C1(NC(=O)[C@H1](SC)C2CC2)CSC1)C3=NC=CS3 CC1(C)C[C@H1](CNC(=O)C2=C(F)C=CN=C2F)N(C(=O)C3=CCCO3)C1 C#CC1=CC=NC(C(=O)N[C@@H1](C)C2CN(C(=O)C3=NC=CC=C3C(F)(F)F)C2)=C1 COC(=O)[C@@H1]1CC[C@@H1](C2=CC=CC=C2)N1CC3=CC(Br)=CN4C=CN=C34 CC(F)(F)[C@@H1](C#N)OC(=O)C1=CC=CC=C1OCC2=CC=C(Cl)C=C2 CC1=C(C)C(C)=C(C(=O)COC(=O)[C@@H1]2CCCN(CC(F)F)C2)C(C)=C1C C=C[C@](C)(O)CC(=O)N1C[C@@H1](F)C[C@H1]1CNC(=O)C2=CN(CC)N=C2C CCC1=CC=C(C(=O)NC2[C@H1]CC[C@H1](NC(=O)CC(F)(F)CS(C)(=O)=O)C2)S1 O=C(NC1CC1)N2CCN(C3=NC(N4CCC5(CC4)CSC5)=NC=6C=C[NH1]C3=6)CC2 CCNC(=O)NC(C)(C)C(=O)N[C@@H1]1COC[C@@H1]1CNC(=O)CS(=O)(=O)C2CC2 CC(C)O[C@H1](COC(=O)C1=NC=CN2CCCC2=C1)C3=CC=CC=C3 CC=1N=NSC=1[C@@H1](C)NC(=O)C2=CC(CNC(=O)[C@]3(CO)CCOC3)=CS2 [N-1]=[N+1]=NC[C@H1](NC(=O)C1=CC=NC(O)=C1)C(=O)N[C@@]23C[C@@H1]2COC34CCC4 CCCC[C@@H1](C)C(=O)N(C)CCNC(=O)C=1C=CN(C)C=1C CC1=NN(CC(=O)N2C[C@@H1](F)C[C@H1](NC(=O)/C(Cl)=C/Cl)C2)C=C1Br C[C@@H1]1C[C@H1]1C(=O)NCCC2(NC(=O)CN3N=NC(C4CC4)=N3)CCC2 C[C@H1]1CC[C@](C)(C(=O)NCC2=NC(C(=O)NN3C=NN=C3O)=CO2)C1 CC[C@@H1](CC(=O)NC[C@@H1](C)C(=O)N(C)CCC1=CC=NC=C1)C2CCC2 COC1=CC=C(CN2CCN(C(=O)C3=CC(Cl)=CN=C3Br)[C@@H1](C)C2=O)C=C1OC C=C[C@H1](O)C(=O)N1CC[C@@H1](N(C)C(=O)C2=CC(Br)=C(OC)C=C2N)C1 CC[C@@H1](CC(=O)N1CCC(OCCNC(=O)C2=CN=C3SC=CN23)CC1)C(C)C CCCN(CC(C)(C)O)C(=O)C1=CN=CC(CNC(=O)C(C)=C2CC2)=C1 CC1=NC=C(C(=O)N2CCC(C)(C)[C@H1](CNC(=O)CC=3C=CON=3)C2)C(C)=N1 C=CCSCC(=O)N(C)[C@@H1](CC(C)C)C(=O)N[C@@H1](CC)CCCO COCCCCC(=O)N[C@H1]1C[C@@H1](F)CN(C(=O)[C@@H1]2CC(=O)OC23CCCCC3)C1 C#CCCCCC(=O)N(CC)[C@H1](C)CNC(=O)C1=NN(C)N=C1C(F)(F)F CC[C@H1]1CN(C(=O)C2=CC=CC(N)=C2C(F)F)CC[C@@H1]1NC(=O)C3CCCC3 CO[C@@H1](C(=O)N[C@H1]1C[C@H1](CNC(=O)[C@@H1](C)NC(=O)C(C)(C)C)C1)C(C)C CC(C(=O)N[C@@H1](CC=1C=COC=1)C(=O)NCC2=CC(C)=C(C)S2)=C3CC3 COC1(C2=CC=CC(C(=O)NC3CCC4(CCC4O)CC3)=C2)CCC1 C=CCN1N=NN=C1[C@@H1](NCCC2=NN=C3C=CC=CN23)[C@H1](OC)C4CC4 FC1=CC=CC2=C1OCC[C@H1]2NC3=NC=NC=4C=NN(C)C3=4 COC[C@@H1](C)[C@H1](C)C(=O)NC[C@H1]1CCN(C(=O)C2=C(F)C=CC(F)=C2F)C[C@@H1]1C CCC(=O)C1(C(=O)NCCCCCCC(=O)N[C@@H1]2CCC(=O)NC2=O)CC1 CC(C)OC1=CC=CC(/C=C/C(=O)N2C[C@H1]3C[C@@]3(CNC(=O)[C@@H1]4C[C@H1]4F)C2)=C1 CC1=NC=C(C(=O)N2CCN(C(=O)C(C)(C)S(C)(=O)=O)C[C@@H1]2C3CCC3)C=C1N CC(=O)N[C@H1](C)C(=O)N1CCC2(CCN(C(=O)CCCCCC(C)C)CC2)C1 CC1=C(CC(=O)N2C[C@@H1](NC(=O)[C@@H1]3CCC[C@H1]3C4CC4)C5(CC5)C2)C=NN1C CC1=CC(C(=O)N2CCC[C@H1](CNC(=O)C[C@@H1](C)[C@@H1](C)C(C)C)C2)=CC(N)=C1O CC1=CN=C(N[C@H1](CNC(=O)C=2C=CC3=NSN=C3C=2)[C@H1](C)C(C)C)N=C1O CCC1=NC=NC(CC)=C1NC(=O)C(=O)N2CCC[C@H1]3[C@@H1]2CCN3C CCC(C)(C)N[C@H1](C)C(=O)N1CC[C@H1](NC(=O)CCC2=CC=C3C(=C2)CCO3)C1 C[C@@H1](CNC1=CC(N2CC3=CC=CN=C3C2)=NC=N1)COC4=CC=CC=C4 CC[C@@](C)(C#N)C(=O)N[C@H1]1CC(F)(F)C[C@H1]1NC(=O)C2=CC=3SC(Cl)=CC=3[NH1]2 O=C(CCF)N[C@H1]1CCOC2(CCN(C(=O)C[C@@H1]3CCCC(=O)N3)CC2)C1 C#CCCCOCC(=O)N1CC([C@H1]2CN(C(=O)C[C@H1](C)C(C)C)CCO2)C1 CC(C)(C(=O)NC1=CC=CC(CN2CCCS2(=O)=O)=C1)N3CCOCC3 C[C@H1]1COC2=C(C(=O)N3CCN(C(=O)CCCS(N)(=O)=O)[C@H1]4CC[C@H1]43)C=NN2C1 CN(C)CC[C@H1](NC(=O)C1=CC=C(F)C=C1)C(=O)N(C)[C@@H1]2CCC(C)(C)C2 O=C(C#C[C@@H1]1CCCOC1)N[C@@H1]2CN(C(=O)CC3=CC=C4C(=C3)CCC4)C[C@@H1]2O COC1=CC=C(F)C=C1C(=O)C(=O)N2CCC[C@H1](CNC(=O)[C@@H1]3CCCN3C)C2 CCC[C@@H1](NC(N)=O)C(=O)NOCC(=O)N1CCN2CCC1CC2 CCCCS[C@H1](C)C(=O)NCC(C)=CC(=O)NCC1=CC=CC=C1C#N CC[C@H1](CC(=O)NC[C@H1](O)CCNC(=O)C1=C(C)SC(C)=C1Br)C2CC2 CC=CC=CC(=O)N1CCN(C(=O)[C@H1]2CCCC=3N=C[NH1]C=32)C[C@@H1]1C(C)C COC1=CC=CC=C1CC(=O)NC[C@@H1]2C[C@H1]3CC[C@H1]2N3C(=O)CCC4=NN=CS4 C#C[C@H1]1CN(C(=O)C=2C=CSC=2)CCN1C(=O)[C@@H1](C)N3CCN(C)CC3 CC1=CC(CC(=O)NC2[C@H1](N(C)C(=O)CO[C@H1]3CCOC3)C(C)(C)C2)=NO1 C#CC[C@H1](NC(=O)C=1N=NN(C)C=1C)C(=O)NCC2(CC(C)C)CCC2 C[C@@H1](CCCNC(=O)C=1C=CSN=1)NC(=O)C2CCC(=C3CCC3)CC2 C[C@H1](NC=O)C(=O)N1CCC2(CC1)C[C@@H1]2C(=O)NC3=CC=CC(Cl)=C3O CCC[C@@H1](NC(C)=O)C(=O)NCCCCNC(=O)C=1SC2=NC=CC(C)=C2C=1C CCSC1=CC=C(C(=O)NC[C@H1]2CCCCN(C(=O)[C@H1]3CO[C@H1](C)C3)C2)C=N1 CC[C@]1(C(=O)N2CC[C@@]3(CC[C@@H1](NC(=O)/C=C/C(C)(C)SC)C3)C2)CNC(=O)C1 C[C@](CNC(=O)CS(=O)(=O)C1CC1)(NC(=O)C2=CC(Cl)=N[NH1]2)C3CC3 C=CC[C@@H1](CNC(=O)C1=CC(N)=CC(O)=C1C)NC(=O)[C@H1](F)C2(O)CCCC2 O=C(C1=CC=CN=C1O)N2C[C@@H1]3C[C@H1](C2)CN(C(=O)[C@@H1]4C[C@H1]5CC[C@H1]4C5)C3 CC1=NC=C(CC(=O)N2CCO[C@H1](CN(C)C(=O)C3(F)CC4(CCC4)C3)C2)S1 CCCCNS(=O)(=O)C1=CC=CN=C1N[C@@H1](C)CC2=CC=C(F)C(Br)=C2 C[C@@H1](C(=O)N1CC([C@@H1](O)C(=O)NCCCCN=[N+1]=[N-1])C1)C2CCCCC2 CCN(CCNC(=O)[C@@H1](F)[C@@H1]1CCN(C(=O)C2=CC=C3C(=C2)CC3)C1)CC(C)C C=C(Br)CC(=O)N1CC2(CC(NC(=O)CC[C@H1]3CCC(=O)N3)C2)C1 CC1=CC=C2C(C(=O)N3CCCCC[C@H1]3CNC(=O)[C@]4(C)CC4(C)C)=CSC2=C1 CC[C@H1](O)[C@@H1](C)C1=NN=C(N2CCCC2=O)N1CC[C@H1](C)OC(C)(C)C CC[C@H1](CCC(=O)N(C)CCNC(=O)[C@]1(C)CC(C2CC2)=NO1)OC CCN1C=C(Cl)C(C(=O)N2C[C@H1]3CC[C@@H1]2[C@@H1]3NC(=O)C=NOC)=N1 COC1=CC=NC(C(=O)N2CC[C@@H1](C(=O)NC[C@@H1]3C[C@H1]4C=C[C@H1]3C4)[C@H1]2C(C)C)=C1 CN([C@H1](CCC1=CC=CC(Cl)=C1)C(=O)NC[C@@H1]2CCOC2)C(C)(C)COC(C)(C)C C[C@H1](NC1=CC=CC(SC(F)(F)F)=C1)C2=CC=C(O)C(C(N)=O)=C2 CC1=CC(C(C)C)=NC(N2CC[C@](C)(NC(=O)C=3C=CN4N=NN=C4C=3)C2)=N1 CC1=NC=2[NH1]C(C(=O)NC[C@H1](O)CNC(=O)[C@H1]3CCN4CCOC[C@H1]34)=CC=2S1 C#CC1=CC=C(NC(=O)[C@@H1](NC(=O)C=2C=NN(C)C=2N)C(C)(C)C)C(C)=C1 CSC=CC(=O)NC[C@]1(C)CN(C(=O)C2=N[NH1]C3=C2CC(C)(C)C3)C[C@H1]1C COCCC[C@@H1](C)C(=O)NCC12CC(CN1C(=O)CCCCC#N)C2 C#CC[C@@H1](O)C(=O)N1CC(O)(C(C)(C)CNC(=O)COC=2C(C)=NN(C)C=2C)C1 C=C[C@H1](CC)CC(=O)N[C@@H1](C)C[C@@H1](C)NC(=O)CCOC1=CC=C(C)C=C1C C=CCCCCCC(=O)NCC(CC)(CC)C(=O)NCCC(F)(F)CC O=C(NC1=CC=C(F)C=C1F)C2=CC=CN2C3CCCC3 CC[C@H1](OC1CCCC1)C(=O)NCCOCCN=C2[NH1]N=C(C3CCCC3)S2 CCSCC1=CN(CC(F)(F)CNC(=O)C=2N=C(C)N3C=2CC(C)(C)C3)N=N1 O=C(NC[C@@H1]1CC[C@H1]1NC(=O)[C@@H1](F)N2C=CN=C2)C3=CC=C(O)C(Cl)=N3 CC(=CC(=O)NCC1=CC=CN=C1)CNC(=O)CC=2C=C[NH1]N=2 C=CC[C@@](C)(CC)C(=O)NCCNC(=O)[C@H1]CC=CC1=CC=CC#C1 CC(C)SCC(=O)N[C@H1](C(=O)N1CCCSC[C@@H1]1C)C2CCCC2 CCN(CCC#N)[C@H1](C(=O)NC1CC(F)(F)C1)C=2C=NN(CC(F)F)C=2C CSCCCC(=O)N(CC1=CC=CC=C1)C2CCN(C(=O)C3=C[NH1]C(C)=C3)CC2 CN(C[C@H1]1CCCN1C(=O)CC[C@@H1]2CCCN(C)C2)C(=O)CCCC(F)F CCC(CC)(CNC(=O)CNS(=O)(=O)N(C)C)NC(=O)C[C@@]1(O)CCCN(C)C1 CSC1=CC(C(=O)NC[C@H1](NC(=O)[C@H1]2CCCC3=CC=CC=C3N2)C(C)C)=CO1 CCC=1ON=C(C)C=1NC(=O)[C@H1]2CCC[C@H1]2NC(=O)[C@@H1](C)CCCC(C)C O=C(NCC1(C2CCC2)CCN(C(=O)C3CC=CC3)CC1)C4=CC=CC=C4CO COCCN1N=NN=C1C2(NCCOC3(C)CCC3)CC(C)(CO)C2 COC=1C(C)=CSC=1C(=O)NCC(C)(C)CN(C)C(=O)[C@@]2(C)CCCOC2 CC[C@@H1]1CN(C(=O)C=2SC(F)=CC=2C)CC[C@H1]1NC(=O)C=CC=3C=CN(C)C=3 CCC1=CC(C(=O)N[C@H1]2CCOC[C@H1]2NC(=O)C3=CC=4C=CSC=4S3)=NN1C CC1=CC(=O)N(C)C=C1C(=O)N2CC(N(C)C(=O)C3=N[NH1]C(=N)[NH1]3)C2 C[C@@H1](O)[C@@H1](C)C(=O)NCC1(NC(=O)C2=C(F)C=C(C(F)(F)F)C(F)=C2F)CC1 CC1CC(CC(=O)N(C)CCOCCNC(=O)C2CC(F)(CF)C2)C1 C=C(C)[C@@H1](CC(=O)N[C@H1]1[C@@H1]2C[C@H1]1N(C(=O)C3=CC=CC(SCC)=C3)C2)OCC C=CCC(O)(CC=C)CNC(=O)NC1=CC(C(C)C)=C(CC)C=C1C CC(=O)N(C)C[C@H1](C)NC(=O)C=1OC2=CC=C(F)C=C2C=1C CCOC1=CC=C(C(=O)NC[C@@H1]2CN(C(=O)[C@@](C)(Cl)CCl)CC2(F)F)N=N1 CCN1CCC[C@@H1](C(=O)N2C[C@H1](C)[C@@H1](CC(=O)NC[C@H1]3CCCC[C@H1]3CC)C2)C1 CCCC=C(CC)C(=O)N1CC(C)(OCC(=O)NC[C@]2(C)CCC[C@@H1]2C)C1 COC1=NC=C(C(=O)N[C@H1]2C[C@H1](CCNC(=O)COCC3CCC3)C2)C=C1C CN(C)C[C@@H1](O)CN=C1C=CC=C(S(=O)(=O)NCC(C)(C)NS(C)(=O)=O)[NH1]1 CC1=C(C(=O)N[C@@H1](C)CN(C)C(=O)[C@@H1]2CCCN2C)SC3=CC(F)=CC=C13 O=COCCN(C(=O)C1=CN=CN1C2=CC(F)=C3C=N[NH1]C3=C2)CC CCCN(C(=O)C[C@@H1](C)CC(C)C)[C@@H1]1CCN(C(=O)CCNC(=O)C=CCl)C1 CCC(=O)N1CC[C@@H1](NC2=CC=C(S(=O)(=O)NCC=3C=CSC=3Cl)C=N2)[C@H1](C)C1 CC[C@@H1](SC)C(=O)N[C@H1]1CN(C(=O)C2=CC=C3C(=C2)OC(C)(C)C3)C[C@@H1]1C CC(C)CC(=O)N[C@H1](C(=O)N[C@H1]1CCN(C(=O)CSC(C)(C)C)[C@H1]1C)C(C)C CN1CCN(C(=O)CC2=CN=CN2C3CC3)[C@@H1](CNC(=O)C4=CN=CN=C4)C1 O=C(C1=CC=CC(F)=C1)N2CC[C@H1]3C[C@]3(C(=O)NCC4(O)CSC4)CC2 COC1=CC=C(C(=O)N[C@@H1](C)[C@@H1]2CCCN(C(=O)C(C)(F)F)C2)C=C1Cl COC1=N[NH1]C=C1C(=O)N[C@H1]2C[C@H1](NC(=O)C3=NC(Cl)=C(Cl)C(N)=C3Cl)C2 CCC(=CC(=O)N1C[C@H1](C)CN(C(=O)[C@H1]2CC[C@H1](C)CC2)[C@@H1](C)C1)CC CC[C@H1](CNC(=O)C1=NC=CC(Cl)=C1Cl)NC(=O)[C@@H1]2CC[C@@H1](O)C2 CC1=CC[C@@H1](C(=O)NC[C@H1]2C[C@](F)(CNC(=O)[C@@H1]3COC(=O)N3)C2)CC1 C[C@@H1](C(=O)N1CCOC[C@@H1]1CNC(=O)C2=CC(Cl)=CC=C2I)C(C)(C)C CC1=CSC(C(=O)NC(C)(C)CN(C)C(=O)C2=CC=CN(CC(F)(F)F)C2=O)=C1 CCCC=CC(=O)N1CCO[C@@H1](C(=O)NC/C=C/C2=CC=CC=C2)CC1 C#CCSCC(=O)N1C[C@@H1](NC(=O)[C@H1](O)C(F)(F)F)CC[C@@H1](C=2C=CSC=2)C1 CC(C)N1N=NC=C1C(=O)NCC[C@H1](C)NC(=O)[C@](C)(O)C2CC2 CC(C)C1=CC=C(C(=O)N2C[C@]3(C)CN(C(=O)C(C)(C)CO)C[C@@]3(C)C2)C=C1 CCCCC[C@H1](F)C(=O)N1C[C@@H1](O)C[C@@H1]1CN2C=C(C3(C(C)C)CCCC3)N=N2 O=C(NC[C@H1]1CCCN(C(=O)[C@@H1](F)C2CCCC2)CC1)C3=CN4C=NN=C4C=N3 CN(C(=O)[C@H1]1C[C@](F)(CO)C1)C2CN(C(=O)CC3=CN=CN=C3)C2 COC1(CNC(=O)C=CC2=CC=CO2)CN(C(=O)C=3OC(C4CCC4)=NC=3C)C1 N#CC1=C[NH1]C(C(=O)NC[C@@H1]2COCC[C@]2(NC(=O)COC3CC3)C)=C1 N#C[C@]1(C(=O)N[C@@H1]2C[C@H1]2NC(=O)CC=3C=CON=3)CC4CCC1CC4 CC=1C=C(CNS(=O)(=O)C2=CC(C)=CN=C2N3CCC[C@H1]([C@H1](C)O)C3)N(C)N=1 CN(C[C@@H1]1CCCN1C(=O)C=2OC=NC=2C3CC3)C(=O)CCC4=CN=C[NH1]4 COC1=NC=C(Cl)C(C(=O)NCC2(F)CCN(C(=O)[C@H1](CCSC)OC)CC2)=C1 CCC1CCC(NC(=O)N2CCC[C@]3(CC[C@@H1]3O)C2)CC1 CC1(CCCCOC(=O)[C@@]2(C#N)CC2(C)C)N=N1 CCCCS(=O)(=O)CC(=O)N[C@H1]1C[C@H1](CNC(=O)COCC2CC2)C13CCC3 C=CCS(=O)(=O)NC1CC(NC(=O)C2=NC=CC3=C2[NH1]C4=CC=CC=C43)C1 O=C(NC1(CO)CN(C(=O)C2=CC(=O)C=C(Cl)[NH1]2)C1)C3=C[NH1]C=C(F)C3=O COC(=O)C1=CC=C(C(=O)NC2CCC(NC(=O)[C@@H1]3CCCC34CCC4)CC2)O1 C[C@@H1]1CN(C(=O)[C@H1]2CC[C@H1]3C[C@H1]32)CC[C@H1]1CNC(=O)CC(=O)OC(C)(C)C CC[C@@H1](C(=O)N(CCCN(C)C)CCNC(=O)[C@H1](O)P(C)(C)=O)C1=CC=CN=C1 CCN(CCCNC(=O)[C@@H1]1CC(=O)N(CCN(C)C)C1)C(=O)C=2C=C[NH1]C(=N)C=2 CCO[C@@H1](C)CCC(=O)N(C)[C@H1](C(=O)N1CC=C[C@H1](O)C1)C2CC2 C=CC[C@@H1](NC(=O)[C@H1]1C[C@H1](N2C=C(C(=O)OC)N=N2)C1)C3=CC=NC=C3 CC1=NSC(Cl)=C1C(=O)NC2=CN=CC=C2C(F)(F)F C=C[C@@H1](C)NC(=NCCN1C2=CC=CC=C2SC1[C@H1]C)NCCC(C)(F)F CC1=NOC(C2CC2)=C1C(=O)N[C@H1]3[C@@H1]4CN(C(=O)C5=CN=C([N+1](=O)[O-1])N5C)C[C@@H1]43 N#CC=1C=NN(CC(=O)N2CC(C3CN(C(=O)C4=CC=CC(Cl)=C4)C3)C2)C=1 CN(CC(F)(F)F)C(=O)C1=NO[C@]2(CCN(C(=O)C3=CC=NC(Cl)=N3)C2)C1 CCN(CCNC(=O)[C@@H1](C)CC1=CC=C(O)C=C1)C(=O)CC2C(C)(C)C2(C)C CC=1N=C[NH1]C=1CNC(=O)[C@@]23CCC[C@@H1]2CCN3C(=O)C[C@@H1](C)O CSC[C@@H1](O)C(=O)NCCSCC(=O)NCC=1[NH1]C(C)=NC=1C CCN(C(=O)CC=1C=CN(C)C=1)[C@@H1]2CCCN(C(=O)CC=3SC(S)=NC=3C)CC2 CCC=1N=NSC=1C(=O)N(CCCNC(=O)[C@]2(C(F)F)CCCO2)C(C)C COCC[C@](C)(O)CNC(=O)CCCN(C)C(=O)CCCCSC C#CCC[C@@H1](O)C(=O)N1CC[C@H1](NC(=O)C2=CC(F)=C(F)C=C2Cl)C[C@H1]1C COC1=CC(C(=O)N[C@H1](C)C2CN(C(=O)[C@H1]3CC[C@H1](O)CN3C)C2)=NC=N1 CC1=CC(C(=O)N(C)C[C@H1]2CC[C@H1](CNC(=O)C=3C=COC=3C)CC2)=CC=C1O C[C@@]1(NC(=O)C=CC2=CC=CS2)CCCN(C3=NC=C4C(=N3)CCCCC4)C1 CN(CC1CCN(C(=O)/C=C/C2=CC=C(S(N)(=O)=O)C=C2)CC1)CC(N)=O C=C(C)C(C)(C)C(=O)NC[C@H1]1C[C@@H1](NC(=O)C2=C(C)N=C3SC=CN23)C1 CC1=CC=C(F)C(CNC(=NCC2=CC=C(C(N)=O)N=C2)NC3CCC3)=C1 CC[C@@H1](CNC(=O)[C@@H1]1CC[C@H1](NC(=O)CN(C)C(=O)COC)C1)CC(C)C CC(C)C[C@@H1](CNC(=O)CC1=CC=C(F)N=C1)NC(=O)CCC2CCSCC2 CC=1C=C(CC(=O)N2CC[C@@H1](NC(=O)[C@H1](C)CF)CC(C)(C)C2)ON=1 CC1=NSC(N)=C1C(=O)NCC[C@H1](C)NC(=O)[C@@H1](C(C)C)N2CCCS2(=O)=O CC1=NC=CC=C1C=CC(=O)O[C@H1](C2=CN=CC=N2)C(F)(F)F CCCC[C@@H1](O)CCC(=O)NC[C@H1](C)N(C)C(=O)[C@@H1]1CCCN1C C#CC1=CC=C(NC(=O)NC2CC(C)(C)S(=O)(=O)C(C)(C)C2)C(Cl)=C1 CC1=CC=C(C(=O)NC[C@H1](NC(=O)[C@H1]2COC3=CC(F)=CC=C3C2)C(C)C)N=N1 CC(C)=C(C)C(=O)N[C@](C)(C(=O)N[C@]1(C)CCC(=O)NC1=O)C2CCC2 COC1(C(=O)NC[C@H1]2CCCC[C@H1]2C(=O)N3CCCCO3)CCC1 CCOC=1OC(C)=NC=1C(=O)N2CCN(C(=O)C(C)(C)NS(C)(=O)=O)CC2 CCCC(=O)NCC(=O)N1CC2(CCN2C(=O)[C@H1](C)[C@H1](O)C(C)C)C1 CC1=CC=C(C(=O)N[C@H1]2CCN(C3=NC=C(C)C(C)=N3)C24CCCC4)C=C1C CCC1=CC=C2C(Cl)=C(C(=O)N3C[C@@H1](O)[C@@H1](CNC(=O)C4(F)CC4)C3)SC2=C1 COC[C@@H1](CC(=O)N[C@H1]1C=CCC1)NC(=O)C2=CC=NC(C)=C2C O=C(N[C@@H1]1CN(C(=O)C2=CC=C3C(=C2)COC3=O)C[C@H1]1O)C4=CC=CC(CO)=N4 COC1=CC=C([C@H1](NC2=NC=NC3=C2N=CN3C4(CO)COC4)C5CC5)C=C1 C[C@]12CC[C@H1]1CCN2CCOC3=CC=CC=C3Br C=C(C)CNC(=O)[C@H1](C1=CC=CC(C(F)(F)F)=C1Cl)N2CC[C@@H1](CC)[C@@H1]2C C[C@]1(CNC(=O)C2(NC(=O)[C@@H1](F)C[C@H1]3CCOC3)CCCC2)C=CCCC1 O=C(N[C@@H1]1CCCC2(CC(O)C2)C1)C3=CC=CC(OCC4=CC=C(F)C=C4)=C3 CN(C(=O)C1=CC(=N)[NH1]C=C1Br)C2CCN(C(=O)[C@@H1]3C[C@H1]3C(F)(F)F)CC2 CC[C@H1](CNC(=O)C[C@H1]1C=CCCC1)NC(=O)C2=NN=CN2CC COC1=C[NH1]N=C1C(=O)NC2([C@@H1]3CCCCN3C(=O)C4=C(Cl)C=NN4C)CC2 CC[C@H1](O)[C@@H1](C)C(=O)N[C@@]1(CF)CCN(C(=O)CC=C(C)C)C1 CCC(=O)NCCNC(=O)[C@H1](C)[C@@H1]1CCCN(C(=O)C2(C#N)CC=CC2)C1 CC(=CC1CC1)C(=O)N2C[C@H1](F)[C@@H1](N(C)C(=O)C3=CN=C(CC(C)C)S3)C2 CNC1=CC=C(C(=O)N2CC[C@H1]3[C@@H1]2C[C@H1]3NC(=O)C4=CCC4)C(Cl)=C1 CC(C)C[C@@H1](C)C(=O)NC1(CCCNC(=O)C2=NN(C)C=C2Cl)CC1 CSCC[C@H1](O)C(=O)N[C@H1](CNC(=O)COC1=CN=CC(Cl)=N1)CC(C)C C[C@@H1]1O[C@H1](C)C[C@@H1]1CC(=O)N[C@@H1](CNC(=O)C[C@H1]2OC(C)(C)OC2=O)C3CC3 COC(=O)NC1=CC=C(C(=O)NNC(=O)NCCCC#N)C=C1 CC/C=C/CC(=O)N(C)CCOCCNC(=O)[C@H1](O)[C@@H1](C)CC C=CC(C)(C)CC(=O)N[C@H1](C)[C@@H1](NC(=O)C=CC1=CN=CC(F)=C1)C(C)C CC[C@](C)(OC)C(=O)N[C@@H1](C)C[C@H1](C)NC(=O)[C@@H1]1[C@H1]2CCCO[C@H1]21 O=C(C[C@@H1]1CC[C@H1]2C[C@H1]12)NCCCN(C3=NC=C(C4=CC=CC=C4)C=N3)C5CC5 CCC1CC(C(=O)NC[C@@H1](O)C2CCN(C(=O)CN3CCCNC3=O)CC2)C1 CN1C=C([N+1](=O)[O-1])C=C1C(=O)NC[C@H1]2C[C@](F)(CNC(=O)[C@H1]3CCC4(CC4)C3)C2 CP(C)(=O)CCCN=C1C=CN=C(NCC2CCN(CC(F)(F)F)CC2)[NH1]1 CC=1C=C(C(=O)NC2=CC=C(NC(=O)C=3C=C(C)ON=3)C=C2C)SN=1 CC[C@H1](C)CC(=O)C(=O)NCCC[C@H1](O)C(=O)N1[C@H1]2CC[C@@H1](C2)[C@H1]1CO C[C@H1](C(=O)NCCCCNC(=O)C1=NC(=N)C=C[NH1]1)C2CCCC2 COCCNC(=O)[C@H1](C1=CC=C(N(C)C)N=C1)N(C)[C@H1](C)[C@H1]2COCCO2 O=C(C=1C=CC(=O)N(O)C=1)N2C[C@H1]3C(CNC(=O)C45CCC(CC4)C5)[C@@H1]3C2 CCC(CC)[C@@H1](F)C(=O)NC/C=C/CC(=O)NCC[C@H1]1C[C@H1](F)C1 COCCOC1=CC(Br)=CC(C2=NC(CC=3C=NSC=3)=NO2)=C1 O=C(C[C@@H1]1C[C@H1]2CC[C@H1]1C2)N(CC3=CC=CS3)[C@H1]4CCOC4 COCCC=CCNC(=O)C[C@H1]1CCCC[C@H1]1NC(=O)C=2C=CC(=O)N(C)N=2 C#CC1(N(C)C(=O)C2=N[NH1]C3=C2CS(=O)(=O)C3)CCCC1 C=CCC(=O)NC[C@@H1](NC(=O)C1=CC(Cl)=C(O)C=C1C)[C@@H1](C)C(C)C N#CC1=CC=C(C(=O)NC[C@@H1]2C[C@@H1]2CNC(=O)C3=CN=CC(Cl)=C3)O1 CC1=C(O)C=CC(C(=O)N[C@]2(CO)CCN(C(=O)[C@@H1]3CSCCS3)C2)=C1C C[C@@H1](NC(=O)C(C)(C)C)C(=O)N(C)CCOCCN(C)C(=O)[C@](C)(O)C1CC1 CC1=COC(C)=C1C(=O)NC[C@@H1]2CCN(C(=O)C3=COC=N3)C[C@H1]2C CCOC[C@H1](C)C(=O)N1CCC2(CCOCC2)[C@@H1](NC(=O)C3=CC=C[NH1]3)C1 C=CC1CCN(C2=CC=NC(N3C[C@H1](C)C[C@@H1](C(N)=O)C3)=N2)CC1 CCOC1=CN=C(C(=O)N(CC)CC(C)(C)CNC(=O)C23CC(C)(C2)C3)C=N1 CC(C)CCC=1N=C(C=2C=CN(CCF)N=2)N(C3=CC=CC=C3C(F)(F)F)N=1 C[C@@H1]1CC2[C@@H1](C)N1CC(=O)NCCC[C@@H1](CN(C)CC#N)C2 COC1(CC(=O)N[C@]2(C)CCCC[C@@H1]2C(=O)NC3(CN(C)C)CC3)CCC1 CC1=CC(C(=O)N2CCN(C(=O)[C@]3(C4CCC4)CC3(F)F)[C@H1](C)C2)=C(O)N=N1 CC(C)(C)C(=O)NCCC1CCN(C(=O)C2=CSC3=NC=CN23)CC1 C[C@@H1]1SC2=CC=C(C(=O)N(C)CCNC(=O)C[C@H1](O)C3CC3)C=C2NC1=O CO[C@@H1]1CN(C(=O)C2(C3CC3)CC(=O)C2)C[C@@H1]1NC(=O)C4=C(N)C=C(F)C=C4F CC[C@@H1](CO)CCNC(=O)C[C@@H1]1CCN(C(=O)C2CC(OC)(OC)C2)C1 CC[C@@H1]1C[C@H1](C(=O)NCCCCOC)CCN1C(=O)[C@H1]2C[C@H1]3CC(=O)[C@H1]2O3 COC1=CN=NC(C(=O)N[C@H1]2C[C@H1](NC(=O)C3=CC=CN(C)C3=O)C2)=C1 CC1=NN(C(C)C)C=C1C(=O)NCC[C@H1]2CCN(C(=O)[C@@H1]3NC(=O)[C@H1]4CC[C@H1]43)C2 C#CC1=CC=CC(C(=O)N[C@](C)(CC)CCNC(=O)C2CCC(CCO)CC2)=C1 CC=1C=C(C)N(C2=CC=CC(CC(=O)N3CC[C@H1]([C@@H1](C)C4=CC=CC=C4)C3)=C2)N=1 CN(CC1(CNC(=O)[C@@H1](CO)N(C)C)CC1)C(=O)C2=C(Cl)N=C3C=CC=CN23 C[C@@H1](CN(C)C(=O)CN(C)C(=O)[C@H1](F)CC(C)(C)C)N1CCCC1 COC(=O)[C@H1](CCF)NC(=O)[C@@H1]1C[C@]12CCN(C(=O)CCOCC3CCC3)C2 C=CCN(CC(=O)OCC)C(=O)[C@@H1]1C[C@]2(CCN2C(=O)OC(C)(C)C)C1 CC(C)(C(=O)NC[C@H1](F)CNC(=O)C(F)(F)C1=CC=C([N+1](=O)[O-1])C=C1)S(C)(=O)=O CCC1=NC=C(CNC(=O)[C@@H1]2CCCN2C(=O)[C@H1](CC)C(C)C)S1 CCNC=CCC(=O)NC[C@@H1](NC(=O)C(C)(CC)CC)C[C@@H1](O)C O=C(C[C@H1]1CCN1C(=O)C[C@]2(O)CCCOC2)NCC(=O)N3CCCO3 CCOC1=CN=C(N2C[C@@H1](O)C[C@H1]2C(=O)NC3=CC=C(F)C(OC(F)(F)F)=C3)N=C1 CCC1(CC)C[C@@H1](O)CN1C(=O)C[C@@]2(C)CCN2C(=O)C3=CN=CC=C3C COC1=CC=C(C(=O)NC[C@H1](NC(=O)[C@@H1]2CNC(=O)N2C)C(C)C)C(C)=N1 CC1=CC(N2CC[C@@H1](NC(=O)CCC3=CC=NC=N3)C24CCCC4)=NC(C)=N1 O=C(COCCNC(=O)C1=CC(Cl)=NS1)N2C[C@H1]3CC[C@]3(C)C2 CC[C@](C)(OC)C(=O)N[C@H1](CNC(=O)C1=CC(F)=CC2=CC=CN=C12)C(C)C O=C(C=CCF)N1CCC[C@H1](NC(=O)[C@]23CSC[C@@H1]2C3)C1 CC[C@@H1]1CN(C(=O)CCC(F)F)CCN1C(=O)[C@@H1](C)N2CCCCC2 COC(C)(C)C(=O)NCCCN(CCO)C(=O)C=1C=C(C)N(C2=CC=CC=N2)N=1 CC1=CC(C(=O)N2CC[C@H1](O)[C@H1](N(C)C(=O)CC3(C)CC3)C2)=NN1C(C)(C)C CCCCC[C@H1](F)C(=O)NC1CCC(CC(=O)N2CC[C@@]3(CNC(=O)O3)C2)CC1 COC(=O)[C@@H1]1C[C@H1]1C(=O)N[C@H1](C)CCCCNC(=O)C2=CC(C(F)F)=NC=N2 C[C@H1]1CC[C@@H1](C(=O)NCC2=CC=C3OC=NC3=C2)N1C(=O)C4=CC(F)=CC(Cl)=C4 CO[C@@H1](C(=O)N1CC(C2CCN(C(=O)[C@@H1](F)CCC(C)C)CC2)C1)C(C)(C)C CC(C)(CNC(=O)COC1=CC=CC(C2CC2)=C1F)NC(=O)CCC=3C=CON=3 C[C@@H1]1CCN(C(=O)C(C)(C)N2C=C(Cl)C=N2)C[C@@H1]1NC(=O)COC(F)F CC(C)(CNC1=C(CN(O)C(=O)[C@@]2(C)C[C@@H1]2C(F)(F)F)N=N1)[N+1](=O)[O-1] CC1=C[NH1]N=C1C2=NC(C3CCC3)=NN2C4=CC(Cl)=CC(Cl)=C4 CN(CC(=O)N1CC[C@H1](NC(=O)CCCC2CC2)C1)C3=CC=NC=C3 O=C(CSC=1N=C[NH1]N=1)N[C@H1](C(=O)NC2(CCO)CCC2)[C@H1]3CCCO3 CCC(C)(CC)C(=O)NC[C@@]1(C)COCCN(C(=O)C2=C[NH1]C(=S)C=N2)C1 CN(C)[C@H1](CCO)C(=O)N1CCN(C(=O)C2(C3CCCCC3)CC2)C[C@@H1]1CF CN(C(=O)CCC1CC1)[C@H1](CNC(=O)C2=CC3=C(C=C2F)NC(=O)CC3)C4CC4 CCCN(C(=O)C=1[NH1]N=NC=1C)[C@@H1](C)C(=O)N2CCO[C@@H1](C(N)=O)C2 C=C1CCN(C(=O)CCCN2C=C(CNC(=O)CC)N=N2)CC1 CC1=CC(C(=O)N2C[C@H1](NC(=O)C3=CN=C(F)C(Cl)=C3)[C@H1](C#N)C2)=CN1C CCC1CCC(N(C)C(=O)CSCCNC(=O)[C@@H1](C)COCC)CC1 O=S(=O)(C=C1C=C(N[C@@H1]2C=CCCCC2)C3=CN=CC=C13)N4CCC(CO)CC4 O=C(C[C@H1]1C[C@H1](NCC2=CN=C3N=CC=CN23)C1)NC4=CC=C(Br)C=C4F CN1CCC(CC(=O)N2CC=C(CNC(=O)C3=CC(Cl)=NS3)CC2)CC1 COC1=CC=CC(F)=C1C(=O)NC2CCN(C(=O)CC=3SC=NC=3C)CC2 CCC1=CON=C1C(=O)N2C[C@@H1]3C[C@H1](C2)[C@H1](NC(=O)C=4SC=C5C=4OCCO5)C3 CN(C[C@@H1]1CCN(C(=O)C2=C(F)C=CC3=C2OCC3)C1)C(=O)CCCCC(N)=O CC1(C)COC(C(=O)NC[C@@H1]2CCC[C@@H1]2NC(=O)C(F)(F)C3=CN=C(O)N=C3O)C1 C[C@@H1](NC(=O)C1CCC1)C(=O)N(C)[C@H1]2CCCN(C(=O)C(F)(F)CCN3C=CC=N3)C2 CC1=CC(CNC(=O)CCN(CCC(F)(F)F)C=O)=NN=C1C CO[C@@H1]1C[C@H1]1C(=O)NCC2=CC=C(C[C@@H1](C)NC(=O)C3=CC(C)=CC=N3)C=C2 CC[C@H1](C(=O)NC[C@H1](CNC(=O)CCCC=1C=CSC=1)C(F)(F)F)N2C=CN=C2 C[C@H1](NC(=O)[C@@H1]1CCN1C(=O)C[C@@H1]2CCOC2)C3=NC(=O)O[NH1]3 CC(=CC(=O)NC[C@@H1]1[C@H1](C2CC2)CCN1C(=O)C3=CN=CC=C3Cl)C(F)F CC1=CC([C@H1]2CCCN2C(=O)NCC(Cl)Cl)=NO1 CC(C)C1=CC(Cl)=NC(NC(=O)[C@H1]2C[C@@H1](NC(=O)NCCCCl)C2)=N1 COC1=NC(OC)=NC(N2C[C@H1](CNC(=O)C3(C(F)F)CCC3)OC4(CCC4)C2)=N1 CC(C)C=1ON=CC=1C(=O)NC2CC3(C2)CN(C(=O)[C@H1](C(C)C)N4C=NN=C4)C3 CCN(CCN(CC)C(=O)[C@H1]1CCSC1)C(=O)CCC2=CC(OC)=NO2 CC(C)(O)C#CC(=O)N1CC[C@H1](O)[C@@H1](NC(=O)C2=CC=NN2CCF)C1 N#CCN1C=CC(C(=O)NCC#CCNC(=O)CC23COCC(C2)C3)=N1 CCCN1N=CC=C1C(=O)NN2CCC[C@H1]2C(=O)N3C[C@@H1](C)OC(C)(C)[C@H1]3C CCCN(C(=O)COC(F)F)[C@H1]1CCN(C(=O)CC2=CC=C(OC)C=C2Cl)C1 CSC1=CC=NC(N2CCN([C@@H1](C)C(=O)NCC3=CC=CC(C)=C3)CC2)=N1 COCCC(C)(C)CC(=O)N1C[C@H1](NC(=O)C(C(C)C)C(C)C)C[C@@H1]1C CSCC(=O)N1CCN(C(=O)[C@]2(C)CC[C@@H1](C)C2)C[C@H1]1C3=NC=CN3C COC(=O)C=1[NH1]C=CC=1C(=O)NC[C@@H1]2CCCN2C(=O)C3=CC4=C(O3)CCCC4 CN1N=C(C(=O)N2C[C@@H1](NC(=O)[C@@H1]3CC34CCC4)C[C@H1]2CO)C=C1OC(F)F O=C(CO[C@H1]1CCN(C(=O)C2=CC=CC(=O)O2)C1)NC[C@@H1]3CCC(=O)NC3 CC(C)(C)SCC(=O)N[C@@H1]1C[C@H1](C(=O)NCC(=O)NCC(F)F)C[C@H1]1O O=C(NC[C@H1]1C[C@H1]1CC(=O)N2CCC(F)(F)[C@H1](F)C2)C3=CC(Cl)=NS3 CC[C@H1](C)CCCC(=O)N1CCO[C@@H1](C(=O)NCC2=CC(C)=CC(C)=C2)C1 COC=1N=C(C(=O)N2C[C@H1]3CC[C@@H1](C2)[C@@H1](NC(=O)C4(C(N)=O)CC4)C3)SC=1C O=C(CN1N=NN=C1C2CC2)N3C[C@@H1](CNC(=O)[C@H1](O)C(F)F)CC34CCC4 COC(=O)C1=C(C(=O)N2CC[C@]3(CCCN3C(=O)[C@@H1]4CCC[C@H1]4CF)C2)C=NO1 COCCOCCOCC(=O)N1C[C@@H1](C)[C@H1](CNC(=O)CC=C(C)C)C1 C#CCN1C=NN=C1C(=O)N(CC)CCNC(=O)[C@@H1]2CCC3=CN=NN3C2 CC(C)(O)CC(=O)NC[C@H1]1CN(C(=O)C2=NC=CC(Cl)=C2O)CC13CCOCC3 COC1=NOC(C)=C1C(=O)N2CCN(CCNC(=O)C=CC3=CC=CS3)CC2 CC=C1C=C2C=C(C(=O)NC3CC[C@@H1]([C@H1](C)N=C4N=CC([N+1](=O)[O-1])=C[NH1]4)C3)[NH1]C2=C1 COC(=O)[C@@](C)(F)C(=O)N1C[C@@H1]2C[C@@H1](NC(=O)C3=CN(C)C(=O)C=C3C)[C@H1]1C2 CCC[C@H1](C(=O)N[C@]1(C(=O)NC[C@@H1]2[C@H1](CO)C2(C)C)C[C@H1]1C)C(C)C CC1=C(N)C=CC=C1C(=O)N[C@H1]2C[C@@H1](CNC(=O)C3=CC=CC=4N=COC3=4)C2 COCCSCC(=O)NC[C@@H1]1C[C@@H1](C)N(C(=O)[C@@H1](O)CN2C=NC=N2)C1 C[C@H1](NC(=O)C=1C=C([N+1](=O)[O-1])N(C)N=1)[C@@H1](C)NC(=O)C2=CC=C(Br)C=C2O CCCCC(C)(C)NC(=O)C[C@H1]1N(C(=O)[C@@H1](C)NC(C)(C)CC)CCC1(C)C CC(C)(C)C1=CC=C(CNC=2[NH1]C(=NCCC3=CC(Br)=CS3)N=C4SC=NC=24)S1 O=C(NC1=CC=NS1)[C@H1]2CN(CC3=CN=C(Br)S3)CCS2 CCCCCCC(=O)C=1SC2=CC=C(F)C=C2C=1CC(=O)OC C=CCCCC(=O)COC(=O)C1=CN=C(C2CCC2)S1 O=C(N[C@H1]1CC[C@H1](NC(=O)[C@H1]2CCCC23CCC3)C1)C4=CC(O)=CC(=O)O4 CO[C@H1](C)C(=O)N1CCC[C@@H1]1[C@H1](C)NC(=O)C2=NC3=CC(F)=CC=C3S2 CC1=NC=NC(C)=C1C(=O)NC[C@](C)(O)CNC(=O)C2=CC=C(C(C)C)C(F)=C2 C1C=N[C@H1](C(=O)NCC2=NC(O)=CC(CNC(=O)[C@@H1](C)C3CC3)=N2)CS1 CCC1=C(C(=O)N[C@H1]2CCC[C@@H1]2NC(=O)C3(CC)CCOCC3)SCCO1 CN1C=C(C(=O)C(=O)NC2CC(CNC(=O)C3(C)CSC3)C2)C=N1 C#CC=1C=NN(C)C=1C(=O)NCC[C@H1](C)NC(=O)CSC2=CC=C(OC)C=C2 COC1=NSC=C1C(=O)N2C[C@@H1](NC(=O)C3(C)C(C)(C)C3(C)C)[C@H1](C(F)F)C2 CCCC1(C(=O)N2C[C@H1]3CC[C@@]3(CNC(=O)C4=CN(C)N=C4C(C)C)C2)CC1 CCN1C=CC(C(=O)N(C)CCOCCNC(=O)[C@@]2(C)CCN(C(C)=O)C2)=C1C COCCC1(C(=O)N2C[C@@H1](NC(=O)C3=CC=[N+1]([O-1])C=C3)[C@H1](S(C)(=O)=O)C2)CCC1 CC(C)C1(C(=O)NCC2(NC(=O)C[C@@H1]3CCC[C@@H1](O)C3)CCC2)CC1 CCC1(C(=O)NCC2(O)CCN(C(=O)[C@@H1]3C[C@@H1](C(F)(F)F)CO3)CC2)CC1 CN1C=CN=C1[C@@H1]2CN(C(=O)C3(CF)CCC3)C[C@H1]2NC(=O)C4(F)CCC4 C[C@@H1](NC(=O)C=1C=COC=1)C(=O)N2C[C@H1](NC(=O)[C@H1](O)C3CCC3)CC24CCC4 C#C[C@H1](NC(=O)CCOCCCNC(=O)[C@@H1](F)C(F)(F)F)C(C)C CN1C=NC(C(=O)N[C@H1]2C[C@H1]3CC[C@@H1]([C@H1]2C)N3C4=CC(C(C)(C)C)=NC=N4)=C1 CCCN1C=C(NC(=O)[C@@H1]2CCCN(C(=O)C3COCOC3)CC2)C=N1 C#CC1=CC=C(NC(=O)[C@H1](F)[C@H1](C)CNC(=O)[C@H1](C)C=2C=NN(C)C=2)C=N1 CN(OCC1=CC=NC=C1)C(=O)[C@@H1]2CCC[C@@H1]2F C=CC1(NC(=O)C[C@H1](COC)NC(=O)[C@@H1](C)SC(C)C)CCCC1 CC(C)(C)OC(=O)N1CCC(=CC(=O)N2CC3(CCCCC3)[C@H1]2C)CC1 CC(C)(C)CC(=O)NCC(=O)N1C[C@@H1]2CN(C(=O)CCC(F)F)CC[C@]2(CO)C1 CC=1C=CSC=1C=CC(=O)N[C@@H1]2C[C@H1]2CNC(=O)C3=CC=CC4=C3CCCC4=O C=C1CC(C(=O)N2C[C@H1](O)C[C@@H1](NC(=O)CC(C)(C)N(C)C)C2)C1 CC=CC=CC(=O)N1CC[C@H1](C)[C@H1]1CNC(=O)C2=CC(Cl)=C[NH1]2 CO[C@H1](C(=O)N1CC(NC(=O)C2=CN(C)N=C2C(C)(C)C)C1)C3=CC=CC=C3F COC1=CC(C(=O)N[C@H1](C)CCN(C)C(=O)[C@H1](OC)C2CCC2)=C(F)C=C1N CC=1ON=C(C(F)(F)F)C=1C(=O)N[C@@H1](C)CCCNC(=O)C=2C=CON=2 O=C(C1=CN=C2N(C1=O)CCS2)N3CC(O)(C4=CN(C5=CC=CN=C5)N=N4)C3 COCCC1(C(=O)NNC(=O)CCC(F)(F)F)CCC1 CC(C)OC[C@H1](C)NC(=O)C1(NC(=O)CN2CCOC2=O)CC(CO)C1 CC[C@@H1](CN(CC)C(=O)[C@@H1](C)S(C)(=O)=O)NC(=O)C=1OC2=CC=C(Cl)C=C2C=1C CN(CCCCCCNC(=O)C(F)(F)C1CC1)C(=O)CCC2=CN=CN=C2 CC(C)C[C@@H1](CNC(=O)C1=CC=C(Cl)C=C1)C(=O)NC[C@@H1](C)CN(C)C CNS(=O)(=O)C1=CC=C(C(=O)NC[C@H1]2[C@@H1]3C[C@H1]2CN3C(=O)[C@]4(C)C[C@@H1]4F)C=C1 C[C@@H1]1C[C@H1](NC(=O)C(C)(C)COC2CCCC2)CN1C(=O)[C@@H1]3C[C@H1]4CCC[C@H1]43 C1=CC=C(O[C@@H1]2CCN([C@H1](C[C@H1]3CCCCC34CC4)C[C@H1]5CCCOC5)C2)C=C1 O=C(NCC1=NC2=CC3=C(C=C2[NH1]1)OCO3)C(F)(F)C4(O)CCCCCC4 CC1(C)[C@@H1](NC(=O)CCCC2CCCCC2)CCN1C(=O)C3=CN=NC(Cl)=C3 CNC1=CC=C(C(=O)N2CCC=3SC=CC=3[C@H1]2CNC(=O)C[C@H1]4CC45CC5)N=C1 CCN1CC[C@@H1](N(C)C(=O)[C@@]2(NC(=O)CC3=CC=CC(C)=C3)CC2(C)C)C1 CC(C)(C)OC(=O)N[C@](C)(CN[C@@H1](CCO)C1=CC=C(Cl)C=C1)C2(C)CC2 CN(CCNC(=O)[C@H1](N1C=CN=N1)C(C)(C)C)C(=O)C[C@@H1]2CCCC3(CCC3)O2 COC1=CC=C(F)C(C(=O)NC[C@]2(C)CN(C(=O)[C@@H1](C)SC)C(C)(C)C2)=C1 COCCC1(NC(=O)C2(C3=CC=CC(F)=C3)CC2)CN(C(=O)C4=CC(C)=NS4)C1 C=C[C@](C)(O)C(=O)N1CC[C@@H1]([C@@H1](F)C(=O)N2CCC3(CCOC3)CC2)C1 COC1=CC=C([C@H1](C)NC(=O)C23CCC(NC(=O)[C@H1]4CC4(C)C)(CC2)C3)C=C1 COC1(CNC(=O)CN2CCOCC2)CN(C(=O)C3=C(C(F)F)C=NN3C)C1 CCC1(C)CC(C(=O)NC23CC(C2)N(C(=O)C4C5CC6CC(C5)CC4C6)C3)C1 CC1=NN=C([C@H1](C)NC2=NC3=CC=CC=C3N=C2NCC4=CN=C(C)N4C)O1 C#CCCCCCC(=O)NCCCNC(=O)[C@@H1]1CC(=O)[C@H1]1C CN(C[C@H1]1CCCN1C(=O)CCC2=CC=NC(Cl)=C2)C(=O)[C@@H1]3CCC34CCC4 CC[C@H1](C(=O)N[C@H1]1CC[C@H1]1CNC(=O)CC(C)(C)OC)N2C(=O)CCC2=O C=C(Cl)C[C@H1](NC(=O)CCC1=CC=NN1C)C(=O)NC[C@H1](O)C(C)C O=C(N[C@H1]1CN(CC2=CN=C3C(Br)=CC(Cl)=CN23)C[C@H1]1F)C4=CN=CO4 C[C@]1(C(=O)N[C@H1]2C[C@H1](CNC(=O)CCCCO)C2)C[C@]1(F)Cl N=C1N=C(CC(=O)N2C[C@@H1]3CCC[C@@]3(NC(=O)C4CN(S(N)(=O)=O)C4)C2)[NH1][NH1]1 C=C[C@H1]1CN(C2=CC(NCC[C@H1]3CCSC3)=NC(C)=N2)CC[C@H1]1CC(=O)OC O=C(NC1=CC=C(CO)N=C1)[C@H1]2C[C@@H1]2NCC3=CC=C(C4=CC=NC=C4)C=C3 C=C[C@](C)(CCOC)C(=O)NC[C@H1]1CC2(CC2)CN1C(=O)C[C@@H1](C)CN(C)C CN1C[C@@H1](O)C[C@H1]1C(=O)N2CC[C@](O)(CNC(=O)C3CN(S(N)(=O)=O)C3)C2 C[C@]1(NC(=O)CC=2C=COC=2)CCN(C(=O)CCCOC3CCOCC3)C1 CC1=NC=CC(CCC(=O)N2CC[C@@H1](CNC(=O)CC[C@@H1]3CC3(Cl)Cl)C24CCC4)=N1 CO[C@@]1(CNC(=O)[C@@]23C[C@@H1]2CCN3C(=O)C(=O)NCC(F)F)CCOC1 CN(CC1=CC=NS1)S(=O)(=O)C2=C[NH1]C=CC2=NC[C@@]34CC[C@@](CO)(CO3)C4 C#CCN(CC(=O)N1CCO[C@@H1]2CCCC[C@H1]21)C(=O)CSCCC#N COC1=CC=C(Br)C(C)=C1C(=O)N(C)[C@@H1]2CCN(C(=O)CS(N)(=O)=O)C2 C[C@@H1]1C[C@H1](C(=O)NCCN(C(=O)C=CC2=CN=CS2)C3CCCC3)CO1 C#C[C@@H1](CNC(=O)[C@@H1]1CCN(C(=O)C=2N=CN(C)N=2)CCO1)CC(C)(C)C CC[C@H1](C)[C@H1](C(=O)N1CC(C)(CC2CCOCC2)C1)C3=CC=CC=C3 N#CCC1(C(=O)NC[C@@H1](CO)CNC(=O)[C@H1]2CCCN3C=CN=C32)COC1 CCN1N=NC=C1C(=O)NC[C@H1](O)CC(=O)NC2CC3(CC(O)C3)C2 CC1=CC=C(CCC(=O)N[C@@H1](C)CN(C)C(=O)C2CCN(C3CC3)CC2)C=N1 N#CCC(=O)N1C[C@@H1]2C[C@H1]1[C@H1](N(C)C(=O)CCNC(=O)[C@@H1]3C[C@@H1]3Cl)C2 C[C@@]1(CC(=O)NC[C@@H1](NC(=O)C2=C(Cl)CCC2)C3CCCCC3)CCS(=O)(=O)N1 O=C(/C=C/C1=CC=C(Cl)C=C1F)N[C@H1]2CN(C(=O)[C@H1]3C=CCC3)CC(F)(F)C2 O=C1N[C@@H1](C(=O)NC2([C@@H1]3CCN(C(=O)CCF)C3)CC2)CCO1 CC1=CC=C(CC(=O)N2CCC[C@H1]3CCN(C(=O)C=4N=COC=4C)C[C@H1]32)S1 COC1=CC=C(CN(C)C(=O)[C@@H1](C#N)C2=NC3=C(Cl)C=CC(Br)=C3S2)C=C1 CO[C@@H1](C(=O)NCC1(C)CCN(C(=O)C2=CC(C#N)=CC=C2F)CC1)C3CCC3 C[C@@H1]1[C@@H1](NC(=O)COC2CCN(C)CC2)CCN1C(=O)[C@@H1]3CCN4N=NN=C4C3 CC(=CC(=O)NC[C@]1(C)CCCCO1)CNC(=O)[C@H1]2CCO[C@@H1]2C(C)C CSC(C)(C)CC(=O)N1CC[C@@H1](NC(=O)[C@H1](C)OC(C)(C)C)C[C@@H1]1C C=C(C)[C@@H1](O)CC(=O)N1[C@H1](CNC(=O)C2=C3N(C(=O)N2C)CCCC3)C[C@@H1]4C[C@@H1]41 CC[C@@H1](CN(CC)C(=O)C[C@@H1]1CCC(=O)NC1)NC(=O)C2=CC=NC(C(N)=O)=C2 CCC1=CC=CC(C(=O)N2CC[C@](C)(CNC(=O)[C@@H1](C)CC)C2)=C1F C#C[C@@H1](NC(=O)[C@H1]1C[C@@H1]1C2CN(C(=O)[C@@H1]3CCCS[C@@H1]3C)C2)C(C)(C)C CC(C)(C)[C@@H1](CO)C(=O)NC[C@]1(F)CCCN(C(=O)C=2C=C3N(N=2)CCCO3)C1 CC1=CSC([C@@H1](C)C(=O)NCC2(O)CC(NC(=O)CN3C=CC(O)=NC3=O)C2)=N1 C#CC1=CC=C(C(=O)N[C@@H1](CCC(C)C)C(=O)NC[C@H1](C)SC)C=N1 N#CC[C@H1]1C[C@H1](NC(=O)C(=O)N2CCO[C@H1](C3=N[NH1]C(CO)=N3)C2)C1 COCCC=1N=C(C2=CC=CC(OC)=C2Br)N(CCC(=O)OC(C)(C)C)N=1 CCC1(NC(=O)[C@H1](O)CCSC)CCN(C(=O)[C@@H1]2CCC[C@H1]2P(C)(C)=O)CC1 CC(C)CC(C)(C)C(=O)NC[C@H1]1CCCN(C(=O)C2=CC=C(C#N)C=C2)C1 CC[C@H1](C)C1=CSC(=NC2CC(N3C=CN=C3)C2)[NH1]1 C[C@@H1]1CCCN(C(=O)CCCCCF)[C@@H1]1CNC(=O)[C@@H1]2CC3=CN=CN3C(=O)N2 CCCN1CCCC[C@H1]1C(=O)N2CCN(C(=O)C=C3CCN(C)CC3)[C@@H1](CC)C2 CC(C)CC1=CC(C(=O)N2CC(N=C3[NH1]C(Cl)=NC4=C3COCC4)C2)=NO1 CC[C@@H1]1CCN(C(=O)[C@@H1](OC)C2CC(C)(C)C2)[C@@H1]1CNC(=O)CSC(F)F CC[C@H1](CC(C)C)C(=O)N1CC(NC(=O)CN2C=CC(O)=NC2=O)C1 O=C(N=C1C=C(Cl)[NH1][NH1]1)C=2N=NN(C3CC3)C=2C(F)(F)Cl CC[C@](C)(C(N)=O)C(=O)NC[C@]1(NC(=O)C2=CN=C(C(N)=O)S2)CCOC1 CCOCC[C@@H1](C)NC(=O)[C@@H1]1C[C@H1](C)CCN1C(=O)[C@H1]2C[C@@H1]3CC[C@H1](C2)O3 COC(=O)C1=CN=C(C(=O)N2CCC(C)(NC(=O)C3=CN=C(Cl)S3)CC2)C=N1 CC1=NC=CC(C2=CC=CC([C@@H1]3C[C@H1]3C(=O)NCCSC4=CC=CC=N4)=C2)=N1 C[C@@H1]1CN(C(=O)C2=CC(=O)C(O)=C[NH1]2)CC[C@H1]1NC(=O)C3(O)CCCCCC3 C[C@H1]1[C@H1](NC(=O)[C@H1](F)C(C)(C)O)CCN1C(=O)CC2=NN(C)C=C2Cl O=C(N[C@H1]1CN(CC2=CC(I)=CC=C2O)CC(F)(F)C1)C3=CC=CO3 COCC[C@@H1](NC(=O)C1=NN(C)C=C1Cl)C(=O)N2C[C@H1](OC)C[C@@H1]2CF C=CCCCC1=CN(C[C@H1](F)CCNC(=O)CC2=CC=CC(Br)=C2Cl)N=N1 CNC(=O)C1=CN(CC(=O)N[C@H1]2CCCC[C@@H1]2NC(=O)C3(OC(C)=O)CC3)N=N1 CC[C@@H1](CC(F)(F)F)C(=O)N1CC[C@@H1](CN(C)C(=O)C2=CC(Cl)=CN2C)C1 COCC(=O)NCCC(=O)NC[C@H1]1CN(C(=O)[C@@H1]2C[C@@H1]3C[C@@H1]3C2)CC(C)(C)O1 C[C@@H1](N=C(N[C@H1]1C[C@H1]1C)N2CCN(CC3CCC3)CC2)C4=CC=C5N=CSC5=C4 COC1=CC=NC(C(=O)NC[C@@H1]2COC(C)(C)CN2C(=O)[C@H1](O)C(C)(C)C)=C1C COC[C@@H1](C)CC(=O)NCCOCCNC(=O)C=1N=NSC=1NC(=O)OC(C)(C)C CO[C@@H1]1C[C@H1]2C[C@@H1](C(=O)N[C@@H1](CO)CNC(=O)C(F)(F)C3=NC=CS3)C[C@H1]21 COC[C@@H1]1CN([C@@H1](C(=O)N[C@H1](C)C(=O)OC)C2=CN3C(Br)=CC=CC3=N2)CCO1 C[C@H1]1[C@@H1](C)[C@@H1]1C(=O)N2CCC[C@H1](NC(=O)CN3CC=CC3)[C@H1]2C C[C@@H1](CC(=O)NCC[C@H1]1CN(C(=O)C2=CC=CC=N2)CCS1(=O)=O)C(F)F CC(C)(C)OC(=O)N1CCC2(CC1)C[C@@H1](NC(=O)[C@@H1]3CCCC4(CCC4)O3)CO2 CC(C)OC1=CC=C(Cl)C=C1C(=O)N2CC[C@@H1](CCNC(=O)CC3=CSN=N3)C2 O=C(N[C@H1]1C[C@@H1]2C[C@H1]1N(C(=O)C[C@H1]3CCCO3)C2)C=4OC=C5C=4CCC5 CN1CCCC[C@H1]1CNC2=NC=CC=C2S(=O)(=O)NC3(C4=CC=CC(Br)=C4)CC3 C[C@@H1](CC1=CC=C(CNC(=O)CSC(F)F)C=C1)NC(=O)CCC2=NC=CN2C CC1(C#N)CCN(C(=O)CC2(CNC(=O)C3=CC=C(C#N)C=C3)CC2)CC1 C=C[C@@H1](CC)C(=O)N[C@H1]1[C@@H1]2CN(C(=O)C3=CC=C(F)C(N)=C3)C[C@@H1]21 C[C@@]1(C2CC2)NC(=O)N(CC(=O)N3CCC(F)(F)[C@H1]3CO)C1=O COCC1=CCN(C(=O)C2CC3(CCN(C(=O)[C@@H1]4CCCO4)C3)C2)CC1 C=C(Cl)C[C@H1](NC(=O)C=1C=CN(C)N=1)C(=O)N2CC3=CC=NC(F)=C3C2 CC1=CC=C(C(C)(C)C(=O)N2CC[C@H1](CNC(=O)[C@@H1]3CCOC(=O)N3)C2)C=C1 IC1=CC=CC2=C(CN[C@H1]3CO[C@@H1](C4=CC=CC=C4)C3)C=CN12 O=C(C1=CC=C(O)N=C1)N2CC3(CC(C(=O)NC4=NC=C(Br)N=N4)C3)C2 N#CC1=CC=CC(CNCC2CCC(C(=O)NC3=CC=C(F)C=C3O)CC2)=C1Cl CN(CCNC(=O)C=C1CCC1)C(=O)C[C@@H1]2CC[C@@H1](C(F)(F)F)O2 C[C@H1](NC(=O)C[C@H1]1CC=CCC1)[C@@H1]2C[C@H1]2C(=O)NC[C@]3(O)C[C@H1]4CC[C@@H1]3O4 O=C(N[C@H1](C(=O)NCCCOC1CC1)C2=CN=C(Cl)S2)[C@H1]3CCCS3 CN(C)[C@H1]1C[C@H1](NC(=O)[C@@]23CCC[C@H1]2CCN3C(=O)C4=C[NH1]C(=N)O4)C1 C[C@H1](NC(=O)C1=CC=C(F)O1)C2CC(NC(=O)C=3SC=NC=3Cl)C2 CCCNC(=O)[C@H1](C1CC=CC1)N2CCO[C@@H1](C3=CC=CC=C3F)C2 CCS(=O)(=O)N[C@H1](C)C(=O)NCC1(COC)CN(C(=O)CC2=CN(C)N=N2)C1 O=C(CC(F)(F)C(F)(F)F)N[C@H1]1CC[C@H1](NC(=O)C=2C=COC=2)CC1 CC(C)N1N=CC(C(=O)N[C@H1]2C[C@H1]3CC[C@@H1]([C@@H1]2F)N3C(=O)[C@@]4(C)CCCO4)=N1 C=C(C)C[C@@H1](NC(=O)CSC(C)C)C(=O)N[C@@H1](C)C1(OC)CCC1 CC(C)[C@@H1](C)[C@H1](CNC(=O)CC1=CC=C(Cl)S1)NC(=O)C2=CC=CC(C#N)=N2 CC1=CC=CC=C1[C@@H1](C)C(=O)N(CCNC(=O)[C@H1](C)CC2CCC2)C(C)C CC=1SC(O)=NC=1C(=O)N(C)CCC(C)(C)NC(=O)[C@H1]2CCN(C)[C@H1]2C CCN=C1C=CC(C(=O)N(CC)[C@@H1]2CCN(C(=O)[C@@H1](C)N3CCOCC3)C2)=C[NH1]1 CC=1C(C(=O)N2CC[C@H1](C3(NC(=O)[C@@H1](COC)N(C)C)CC3)C2)=NOC=1C4CC4 CC1=CC=C(C(=O)N[C@H1]2CC[C@H1](NC(=O)C=3C=C[NH1]C=3C)CC2)C(C4CC4)=N1 N#CC1=CC(F)=CC=C1C(=O)NC2(CNC(=O)[C@H1]3CCC4(CCC4)CO3)CCC2 O=C(NC1CN(C(=O)[C@H1]2CCN(CC3=CC=C(Cl)C=C3)C2)C1)[C@@H1]4C[C@@H1]5C=C[C@H1]4O5 CC1=CC=CC(CC(C)(C)NCC2=C(C)C=CC=C2I)=C1 CSCC[C@H1](O)C(=O)N1CCC[C@@H1](CNC(=O)C=CC2=CC=C(C)S2)C1 COC(=O)C1=NSC(I)=C1NC(=O)N[C@H1](CO)C2=CC=CC(Cl)=C2C CCC(=O)N1CCN(S(=O)(=O)C2=CC=C(N3CC(C)(C)[C@H1]3C(C)C)C(F)=C2)CC1 CC1=NO[C@H1](C(=O)N2CC(NC(=O)C[C@H1](C)C3CC3)(C4=CC=CC=C4)C2C)C1 C[C@@H1]1C[C@@H1](NC(=O)C2(N(C)C)CC2)CN(C(=O)CCCCCCCC3CC3)C1 CC(C)CCCCC(=O)NC1CN(C(=O)CN2C=NC(C(F)(F)F)=C2)C1 COC1=CC=C(Cl)C=C1CC(=O)N2C[C@@H1]3C[C@@H1](NC(=O)C4(N(C)C)CC4)[C@H1]2C3 COCCO[C@H1](C)C(=O)N1C[C@@H1]2CCN(C(=O)C=3C=C(CC4CC4)ON=3)C[C@@H1]2C1 CC(C)OC1=NC=C(C(=O)N2C[C@@H1](NC(=O)CN3CCC[C@H1]3C)[C@H1](C)C2)C=C1Cl C[C@@H1]1C[C@@]1(C)C(=O)N2C[C@H1]3C[C@H1](NC(=O)CCCC#N)C[C@H1]3C2 CC(C)CC1=NC=C(C(=O)N2CCC[C@H1](CCNC(=O)[C@]3(F)CC3(F)F)CC2)[NH1]1 C[C@@H1]1CN(C(=O)C2=CC(Cl)=C(Cl)C=C2N)CCCN1C(=O)C=C[C@@H1]3CCOC3 CCC1=C(C(=O)N[C@@H1](CC(=O)N[C@@H1](C)C=2C=N[NH1]C=2)C(F)(F)F)N=NN1C CCC(CC)OCC(=O)N1CC(CC)(C(=O)N2CC[C@H1]3CCCC[C@H1]3C2)C1 CNC(=O)NCCCNC(=O)[C@@H1]1CCCN(C(=O)C23CCCN2CCC3)CC1 CC1=C([C@@H1](C(=O)NCCCF)N2CCC[C@H1](N3C=CN=C3)C2)C=CC=C1[N+1](=O)[O-1] CC1(CN=C2[NH1]C=NC(Cl)=C2Br)CCN(C(=O)C=CC(=O)NC3CC3)CC1 O=C([C@@H1]1CC=CCN1C(=O)C=2C=CN3C=NC=C3C=2)N4CCC5(CCC5)CC4 CCC(=O)N1CC2(CCOCC2)C[C@@H1]1CNC(=O)C3=CC=CC(C=4C=CSC=4)=C3 CCCN(CCNC(=O)CC(C)(C)C(F)(F)F)C(=O)C1=CN=C2C(=C1)CNC2=O C[C@@H1](CC(F)(F)F)C(=O)NC[C@H1]1CCCCCN1C(=O)C2=NOCC2 C#CCCCOCC(=O)N[C@H1]1C[C@H1](NC(=O)C2=CSC(Br)=N2)C13CCC3 C[C@@H1]1CCCC[C@@]1(CNC(=O)C2=CSC(Cl)=C2)NC(=O)C3=CN=C(O)C=C3O CC=1N=CSC=1CCC(=O)N[C@@H1]2CCC(C)(C)C[C@H1]2CNC(=O)C(C)(C)CF N#CC1=CC=CC(C=CC(=O)N2CC[C@@H1]3OCCC[C@H1]3C2)=C1 O=C(C=1C=C(Cl)SC=1Cl)N2C[C@@H1]3CCN(C(=O)C4=CC=C(F)C=N4)[C@@H1]3C2 C[C@](CNC(=O)C1C[C@@H1]2COC[C@H1]2C1)(NC(=O)CSC3CC3)C4CCC4 CC1=NN(C)C=C1C(=O)N[C@H1](CO)[C@H1](C)NC(=O)COCCCF CC1=CC=C(C(=O)N2C[C@H1]3CCN(C(=O)CC4=CSN=N4)CC[C@H1]3C2)C(F)=C1 CCOC1=CC=C([C@@H1]2[C@H1](C(=O)NN(C)C3=CC=CN=N3)CCC(=O)N2)C=C1 CC[C@H1](CC(F)(F)F)C(=O)N(C)C[C@@H1](O)CN(C)CC(=O)NC O=C(N[C@@H1]1[C@H1]2C[C@@H1]1N(C(=O)C[C@@H1]3C(=O)NC4=CC=C(Cl)C=C43)C2)[C@H1]5CC5(F)F COCC1CCN(C(=O)C[C@@H1](NC(=O)C2=COC(C)=C2)C(F)(F)F)CC1 CC1(C)O[C@H1]2CCN(C(=O)C3(O)CCCCC3)C[C@H1]2C1 C[C@H1](C[S@](C)=O)NC=1[NH1]C(=NCC2=CC=CC(F)=C2F)N=C3SC=NC=13 CC(C)[C@@H1](O)C1(CNC(=O)CN2CCN(C(=O)[C@H1]3CCCC(=O)C3)CC2)CC1 O=C(NC[C@H1](O)C1=CC=C(O)C=C1)[C@]23CC=CCN2CCC3 O=C(CCOC=1C=CSC=1)N[C@]2(CNC(=O)CCC3CCCC3)CCOC2 O=C(NC[C@@H1](O)CNC(=O)[C@@H1]1CCCC12CCC2)C3=N[NH1]C4=C3CCCCC4 C#CCN(CCC(=O)NC1(C(=O)OC)CC1)C(=O)C[C@@H1]2C(=O)NN=C2C C=C[C@@H1](C)CC(=O)NC[C@H1]1CN(C(=O)C2=CC=C3C=CC=NN23)CC14CC4 C[C@@H1]1C[C@H1](C(=O)NCCCC(=O)N(C)C)CO1 CN(CC[C@H1](NC(=O)CS(=O)(=O)C(C)(C)C)C(C)(C)C)C(=O)C[C@@H1]1CCOC1 CCCC(CCC)CNC1CC(OC2=CC=C(F)N=C2)C1 CC1=NC(CC(=O)N[C@H1]2C[C@H1]3C[C@H1]2N(C(=O)[C@H1](C)CN4C=CN=C4)C3)=CO1 C[C@H1]1CN(C(=O)[C@@H1]2C[C@@H1]3C=C[C@H1]2CC3)CC[C@@H1]1CNC(=O)C4(S(N)(=O)=O)CC4 C=CCC[C@H1](NC(=O)C=1N=C[NH1]N=1)C(=O)N2C[C@H1]3C[C@@H1](C2)N(C)C3 CC[C@@H1]1CCN(C(=O)C2=CC(C)=NO2)[C@H1]1C(=O)NCCC[C@@H1]3C[C@H1]3C CN(CC[C@H1]1CCCCN1C(=O)C2=NC=C3C(F)=CC=CN23)C(=O)C(C)(C)O COC1=CC=C(C2(C(=O)N3C[C@@H1](NC(=O)C=C(C)Cl)CC4(CCC4)C3)CC2)C=C1 CC1=CC(C(=O)N[C@]2(C)CCN(C(=O)C3=CN=C(C4=NC=CC=N4)S3)C2)=CC=N1 NC1=CC(F)=C(O)C=C1C(=O)NCC23CC(NC(=O)C4=CSC=N4)(C2)C3 N#C[C@H1]1CCN(S(=O)(=O)C2=CC=CN=C2N[C@@H1]3CCN(CC4CC4)C3)C1 CN1C(=O)CC[C@@H1]1C(=O)N2CCCC[C@H1]2CCCNC(=O)C=CCN3C=NC=N3 C#CC1=CC=CC(C(=O)NC(C)(C)CCNC(=O)C[C@@H1](CC)CCCC)=C1C CN1CCC[C@](F)(C(=O)N[C@H1]2C[C@@H1](CNC(=O)C34CCC(CC3)C4(C)C)C2)C1 C[C@H1]1CN(C(=O)CCCC#N)C[C@@H1](C(=O)NCCC2COC2)O1 CC1=NN=C(CC(=O)N[C@@H1]2C[C@@H1]3C[C@H1]2N(C(=O)[C@H1]4CCO[C@H1]4C)C3)O1 CC1(C)CC(C)(C(=O)NCC2(O)CN(C(=O)C3CC4(C3)CC(F)(F)C4)C2)C1 CCCCCCNC(=O)[C@H1](C1=CC(Cl)=CC(Cl)=C1Cl)N(C)[C@H1]2CCN(C)C[C@@H1]2C CC1=CC(C(=O)N(C)[C@H1](C)CNC(=O)C2=CC(C)=C(C)C3=NC=CC=C23)=NN1C O=C(C1=COC(Br)=C1)N2CCCC[C@H1]2CN=C3C=CN4N=CC=C4[NH1]3 CC1=NN2C=CC=NC2=C1C(=O)NCC(C)(C)CNC(=O)[C@@H1](C)C3=CC=NN3C CCOC(=O)N1CSC[C@@H1]1C(=O)N[C@@H1]2C[C@@H1]2NC(=O)C3SCCS3 C=C[C@@H1](O)C(=O)N(C)CC[C@@H1](NC(=O)C=CC1=CN=C(O)N=C1O)C(C)(C)C CCCC=CC(=O)NC[C@@]1(NC(=O)C2=CC(O)=NC3=CC=CC=C23)CCOC1 C#C[C@H1]1[C@H1](C(=O)N2C[C@H1]3C[C@H1]2CN(C(=O)C4=CC(C)=CC(C)=C4)C3)C1(C)C CCOCCC(=O)N1CC[C@@H1]([C@H1]2CCN(C(=O)C3=CC=C(Cl)N=C3N)C2)C1 N#CC1=CSC([C@@H1](C(=O)NC2COC2)N3CC[C@H1](O)C(F)(F)C3)=C1 CC1=CC(C(=O)N[C@H1]2CN(C(=O)C3=C[NH1]N=C3C)CC[C@H1]2C)=C4C=CC=CC4=N1 CC1=CC=CC([C@H1](C)NC(=NCC2CCC2)NC3CCN([C@@H1]4CCOC4)CC3)=C1 C[C@H1]1CCCN(C2=CC=C(C(=O)N3C[C@@H1](C)CC3(C)C)C=C2CO)C1 O=C(C[C@H1]1CCCS1(=O)=O)N[C@@H1](CNC(=O)C2=CC(F)=N[NH1]2)C3=CC=C(F)C=C3 C=CCN1C=C(NC(=O)[C@@H1](NC(=O)[C@H1](CC)C(=O)OC)C2CCCC2)C=N1 CC1=CC=C(S(=O)(=O)NC2[C@H1]3CN(CC4=NC(Cl)=CC=C4F)CC[C@H1]3C2)C=C1Cl CCCOCCC(=O)NC[C@@H1]1CN(C(=O)C2=CC(=O)N(C)O2)CCCO1 C[C@@H1](C(=O)N1C[C@@H1]2CCC[C@H1](C1)N2C(=O)[C@@H1]3CC=CC[C@H1]3C)N4C=CC=N4 CC[C@](C)(CNC(=O)CC1=CC=C(F)C(F)=C1)NC(=O)[C@H1]2CCCO2 CCC1=CC(C(=O)NC[C@H1]2C[C@@H1](C(=O)NCC3[C@@H1]4CCC[C@@H1]34)C2)=CC=N1 CO[C@H1]1C[C@H1](C(=O)N[C@@H1](CNC(=O)C2=CC=C[NH1]2)C3=CC=CC=C3)C1 CC1(CCC(=O)N2CC[C@H1](OCCNC(=O)[C@@H1]3CCC4=CC(Cl)=CC=C43)C2)N=N1 CCC[C@@H1](CC)CC(=O)N1CCC[C@@H1]1CN(C)C2=NC=C(C)C(C)=N2 COC(=O)CCN(C)C(=O)[C@@H1](O)CCNC(=O)CCC=1C=CN(C)N=1 CC1=CC=C(Cl)C=C1C(=O)N[C@H1]2CCN(C(=O)[C@@H1]3CCC(=O)N3C)[C@H1](C)C2 CCNC=CCC(=O)N1CC[C@@H1](NC(=O)C2CC3(CC(=O)N3)C2)[C@@H1](CO)C1 CN1CC[C@@](C)(CNC(=O)[C@H1](NC(=O)C2=CN=NN2C)C3=CC=CO3)C1 CC1(C(=O)NCC2=CC(C(=O)N3CCN4N=CC=C4C3)=NO2)CSC1 CC1=CC(O)=NC=C1NC(=O)C2=CC=C3OCCOC3=C2 CC1(C)CCN(C(=O)[C@H1]2CC(=O)N(C3CC3)C2)C[C@H1]1NC(=O)CN4C=CC=N4 COC[C@@H1]1CN(C(=O)[C@@H1](NC(C)=O)[C@H1](C)O)CCN1C(=O)C2=CN(C)N=C2C C[C@@H1]1C[C@H1](C(=O)NC[C@@H1](CO)CNC(=O)C23CC(F)(C2)C3)CN1C C[C@@H1](CCN(C)C(=O)[C@H1]1CCCC2=NC=CC=C21)NC(=O)C3=CC=NS3 CC1=CC=C(C(=O)NCCCCNC(=O)C2=CN=C(C)C(C)=C2)C=N1 CC1=NC=C(Cl)C=C1C(=O)NC[C@H1](C)[C@]2(O)CCN(C(=O)CCC=3N=C[NH1]N=3)C2 C[C@@H1](C(=O)N1C[C@@H1](N(C)C(=O)CCCNC(N)=O)C(C)(C)C1)C(C)(C)O CCCS(=O)(=O)N[C@@H1](C)C(=O)N[C@H1](CNC(=O)C1=CC(C)=CC=C1Cl)C2CCC2 CC(C)=C=CC(=O)N1CC[C@@H1](NC(=O)CCS(N)(=O)=O)[C@@H1](F)C1 CC[C@H1]1[C@@H1](NC(=O)C2=CN=CC(C(C)C)=C2)CCCN1C(=O)CC3=CN=NN3C CCCCC=1C=C(NCC#CCNC(=O)[C@H1]2CCCN3N=CC=C32)N4N=CN=C4N=1 CC(C)(F)CC(=O)N1CC(C)(C)C(NC(=O)[C@H1]2CCN3CCOC[C@@H1]23)C(C)(C)C1 COC1=CC=CC(Cl)=C1C(=O)NC[C@]2(O)CCCN(C(=O)C3(OC)CCCC3)C2 CC1=NSC=C1C(=O)N(C)CCNC(=O)[C@H1]2NC[C@H1]3[C@@H1]2C3(C)C CN1CCN(C(=O)C2=CSC(CNC(=O)CC(C)(F)F)=C2)C[C@@H1]1C(C)(C)C CC1(C)C[C@@H1](NC(=O)CCCC2CCCC2)CN1C(=O)CCCSC(C)(C)C CCOC[C@H1](N=[N+1]=[N-1])C(=O)NC(C)(C)CCNC(=O)CCOC1=CC=CC=C1 C[C@@H1](C1=CC=CC(Cl)=C1)S(=O)(=O)NCC2=CC=C(F)C3=C2OCC3 CC1=CC(CC(=O)N2CC[C@H1](NC(=O)COCCCF)C2)=CC=C1O CC(C)CN1CCC(C(=O)N[C@@](C)(CNC(=O)C2=CC=NN=C2O)C(C)C)CC1 C#CC1=CC=CC(NC(=O)[C@@H1](O)CNC(=O)[C@H1](C)CCCCCC)=C1 C=CC[C@]1(NC(=O)CS(=O)(=O)NC)CCN(C(=O)C2=CC=NC3=CC=NN23)C1 CSC=CC(=O)N1CCC(CC2CCN(C(=O)[C@@H1]([C@@H1](C)O)N(C)C)CC2)CC1 COC(CN=C1C=C(C)N=C(N2C=CC=N2)[NH1]1)OC CCN1CCC[C@@H1]1CNC=2[NH1]C(=NCC[C@@H1](OC)C(C)C)N=C3C=2C=NN3C CCCCS[C@@H1](C)C(=O)N1CCC[C@@H1](CN(C)CC2=NN=C(C)O2)C1 C[C@@H1](C(=O)NC[C@H1]1[C@@H1]2C[C@H1]1CN2C(=O)C3=CC(Cl)=CC4=CC=CC=C34)N(C)C COCC12COC(C(=O)N3CC[C@@H1](CCNC(=O)[C@@H1](NC(N)=O)[C@@H1](C)O)C3)(C1)C2 CCC1=NSC(N2CCN(C(=O)[C@@H1](C3=CC=CC=C3)C4CCCC4)C2)=N1 CC1(CNC(=O)C2=CC=3SC=CC=3C=N2)CC(NC(=O)CN4C=NC=N4)C1 CN(C)CCC(=O)N1C[C@@H1]2CC[C@H1](C1)[C@H1]2NCC3=CN=CS3 C[C@@H1]1C[C@@H1]1CN(C)C(=O)[C@H1](CNC(=O)C(=O)C(C)(C)CC)CC2CCCC2 C=C(C)CN1N=NN=C1[C@H1](CCOC)NCC(CO)(CO)CO CC(C)N1CCC[C@@H1]1CC(=O)N2CC(CNC(=O)C3=CC=NN3C4CC4)C2 NC(=O)C(=O)NCC(=O)N1CCC[C@H1]1C(=O)NCCC(=O)N2CCCC2 O=C1C[C@@H1]2[C@@H1](CCN2CC=3C=CN(C4=C(F)C=CC=C4F)N=3)O1 CCCCSCC(=O)N(C)CCCCCNC(=O)CN1C=NC=N1 CCC[C@H1]1CN(C(=O)C2=CC=CC3=CC=NN23)C[C@@H1]1C(=O)NC4=CC=C(Cl)C=C4 COC1=CC=CC([C@@H1](C)CC(=O)NC2CC3(C2)CN(C(=O)[C@@]4(C)C[C@@H1]4C)C3)=C1 CSCC1(CC(=O)N(C)C2CCCN(C3=NC4=CC=CN=C4S3)C2)CC1 CC=1[NH1]N=C(C(=O)N2C[C@H1]3[C@H1](CC(=O)NCC[C@@H1](C)CCO)[C@H1]3C2)C=1O C=CC[C@@H1](NC(C)=O)C(=O)N[C@H1]1C[C@H1]1NC(=O)C2=CC=C(C3=CC=CS3)N=C2C O=C(N[C@@H1]1CN(C(=O)CC2=CN=C(C(F)(F)F)S2)C[C@@H1]1O)C3=CN=CS3 CC[C@@H1](CC(=O)N1C[C@@H1](CC(=O)NCC2(CC(N)=O)CC2)C3(CC3)C1)C(F)F C[C@@H1](CCC(=O)NC[C@@]12CC[C@@H1](CO1)C2)NC(=O)C3=C(F)C=CC=C3F CC=1C=CSC=1CCCC(=O)N2C[C@@H1]3C[C@H1]2CN3C(=O)CN(C)[C@@H1]4CCC[C@H1]4O CC(C)(C)C1(C)CC(C(=O)N2CCN(C(=O)CCC3=CN=C[NH1]3)[C@@H1]4COC[C@@H1]42)C1 CCC(C)(C)C1CCC(CC(=O)N2C[C@@H1](C)C[C@@H1](NC(=O)C3=CCC3)C2)CC1 CC(C)C1=CC=C(C(=O)NC2(C)CN(C(=O)CC34CCC(CC3)C4(C)C)C2)C=N1 CCN1C=NC=C1[C@@H1]2CCCCN2C(=O)C3=CC4=C(C)C=C(OC)C=C4[NH1]3 C[C@H1](C(=O)NCCC1(O)CN(C(=O)CC2=CN=CS2)C1)N3C=CC(Br)=N3 C[C@H1](C(=O)N[C@@H1]1CN(C(=O)C2=CC(Cl)=CC3=CC=NC=C23)C[C@H1]1C)[C@@H1](C)O CC1=CC(C(=O)N[C@@H1]2CCC[C@@H1](NC(=O)C3=CC=C4OC=CC4=C3)C2)=NC(O)=N1 CC(C)N(C)CC1=CN([C@@H1]2CON(C(=O)[C@]3(C)CCC(=O)N3)C2)N=N1 O=C(N[C@H1]1C[C@H1](NC(=O)C(F)(F)C(F)(F)F)C1)[C@@H1]2CCC[C@@H1]3[C@H1]2C3(F)F CCOCCCCC(=O)N1C[C@@H1]2CC[C@H1](C1)C2NC(=O)CC=3C=C(C)SC=3C C=CC1(NC(=O)C/C=C/CNC(=O)[C@@](C)(O)CCC)CCCC1 C[C@]1(NC(=O)C=2C=CN3C(O)=NN=C3C=2)CCN(C(=O)C4=CC=CC(O)=C4Cl)C1 C=CCN1C(C=2N=COC=2C)=NN=C1N(C)[C@H1](C)CC CC(C)N1N=NN=C1[C@H1](NC2=CC=C(CO)C(F)=C2)C3=CC=C4N=C(O)[NH1]C4=C3 CSCC[C@H1](C)N(C)C(=O)[C@@H1](CC(C)C)NC(=O)CCN1CCOCC1 CN(CC1=NC=CC=C1C2CC2)C(=O)CCC=3C=NN(C)C=3 C[C@@H1](NC(=O)[C@H1]1CNCCN1CC2=CC=C(CC(=O)O)C=C2)C(F)(F)F CCC(C)C(=O)N1C[C@H1]2[C@H1](NC(=O)C=CBr)[C@H1]1C2 O=C(CC1=CC=CC=N1)N[C@H1]2C[C@]3(NC(=O)C4=CSC5=CC=CC=C45)CO[C@H1]2C3 COC1=NN(C)C=C1C(=O)N2C[C@@H1](CNC(=O)C=CC3=CC=C(C)S3)CC[C@H1]2C CC1=COC(C=CC(=O)N[C@H1](C)CNC(=O)C23C[C@H1]4C[C@@H1](CC(C)(C4)C2)C3)=N1 C=CC[C@@H1](C)C(=O)N(CC)[C@H1](C)CNC(=O)CNC(=O)C1=CC=C(F)C=C1 O=C(CCC1=CC=NC(Cl)=C1)NC[C@H1]2CCN(C(=O)C=3N=C(Cl)SC=3Cl)C2 CNC(=O)C(C)(C)C(=O)NC[C@@H1]1CCN(C(=O)C2=CN=CC(OC)=N2)C[C@@H1]1C CNC1=CN=CC(C(=O)N2CCN(C(=O)C3=CC(C(N)=O)=CS3)[C@@H1]4CCC[C@@H1]42)=C1 C[C@]1(C(=O)N[C@@H1]2COCC[C@@H1]2NC(=O)C=3C=NN4C(Cl)=CC=CC=34)CCCO1 C=CC[C@@H1](CC)C(=O)NC[C@H1]1CN(C(=O)CS(=O)(=O)NCC)CC2=CC=CC=C21 COCCCC(=O)N[C@@H1](CNC(=O)[C@@H1]1CC(=O)NC1(C)C)C2CCCC2 C=CC[C@]1(NC(=O)CCCCF)CCN(C(=O)C2=CC(OC)=C(N)C=C2F)C1 C=CCC[C@@H1](NC(=O)C1=N[NH1]C=C1CC)C(=O)N(C)[C@@H1]2CCCC(C)(C)C2 CON(CC1CCCCC1)C(=O)[C@@H1](NC(=O)CCN(C)CCO)C=2C=COC=2 C#CC[C@]1(C(=O)NC2=CN=C(CC)C(C)=C2)CCN(C(=O)C3=NN=CC=C3C)C1 O=C(C[C@@H1]1[C@@H1](NC(=O)C2[C@@H1]3COC[C@@H1]23)C[C@H1]1O)N4CC(N5C=NN=C5)C4 CCCCCCCC(=O)NC[C@@H1]1CN([C@H1](C)C(=O)NCCC(C)C)CCO1 C[C@H1]1C2=C[NH1]N=C2CC[C@@H1]1C(=O)NCC3=CCN(C(=O)C4=CCC4)CC3 CN(C[C@H1]1CCN(C(=O)C2(N3C=NN=N3)CC2)C1)C(=O)C(C)(C)CC(C)(C)C CN1CCC(OCCC(=O)N2CCC[C@@]3(CCN(C(=O)[C@H1]4C[C@H1]4F)C3)C2)CC1 C[C@@H1](CO)C(=O)N(C)CCCNC(=O)CC1=CC=C(Cl)C=C1 CN1C=CN=C1CC(=O)N2CCC[C@](F)(C(=O)N3CC(CC4CC4)C3)C2 O=C(CC1=CSC(Br)=C1)N[C@@H1]2C[C@@H1]3C[C@H1]2N(C(=O)C4CC=CC4)C3 CC1=CC(C(=O)N2CCC[C@H1](CN(C)C(=O)C34CCOC(C)(C3)C4)C2)=CN=N1 CC(=CC1=CC=CS1)C(=O)N2C[C@@H1](C)[C@](C)(CNC(=O)C3=COC(C)=C3)C2 CC(C)(C)OC(=O)N1CCOC[C@@H1]1C(C)(C)C(=O)N2CCNC(=O)C[C@@H1]2C COC1=NN(C)C(Br)=C1C(=O)NC[C@](C)(O)CNC(=O)[C@@]23C[C@@H1](OC)[C@@H1]2C3 COC(C)(C)C(=O)N1CCC(N=C2[NH1]C3=CC=CC(Br)=C3O2)CC1 C/C=C/C(=O)N1CCOC[C@@H1]1CC(=O)NC2=CC3=N[NH1]C=C3C=C2C(=O)OC COCCN1C=NN=C1C(=O)N2CCN(C(=O)[C@H1](C)C3=CN=CN=C3)[C@H1](C)C2 NS(=O)(=O)C1=CC=C(C(=O)N(CCO)[C@@H1]2CCN(C(=O)[C@H1]3CCCC(=O)N3)C2)O1 C=CC[C@@H1](CNC(=O)CN1N=CN=N1)NC(=O)CCC2=NC(C(C)(C)C)=NO2 CCN(CC)C[C@@H1](F)C1=NC(C2=CC=NC=C2)=NN1CC3=CC=CC=C3Cl CN1N=CC(Cl)=C1C=2C=C(C(=O)NCC3CSC3)N(CC4CC4)N=2 CC1(C)C(CNC(=O)CCSCC(F)(F)F)CCN1C(=O)C2CCC(=O)NC2 CC=1[NH1]N=C(C(=O)N[C@]23C[C@H1]2CN(C(=O)[C@@H1]4CC(F)(F)C4(C)C)C3)C=1Br C[C@H1](CCN(C)C(=O)CC1=CN=CN=C1O)NC(=O)C2(F)CCCCC2 CC(C)[C@@H1](C)CC(=O)NC1(CN(C)C(=O)[C@@H1]2CC[C@H1]3[C@@H1](CC2)C3(F)F)CC1 O=C(C=CCN1CCCC1)NCCC2(NC(=O)C3=CN=CC=C3Cl)CCOCC2 CN(C(=O)CCC1=CC=C[NH1]1)[C@@H1](CC(F)F)C(=O)NCC=2C=CN(C3CC3)N=2 COCC(C)(COC)C(=O)N1CCC[C@H1](CNC(=O)[C@@H1]2[C@H1]3CCCC[C@H1]32)C1 CC[C@@H1]1[C@@H1](C(=O)NOCC(C)(C)O)CCN1C(=O)C2=CC(C)=CC(C#N)=C2 CC1(C)CC2=CC(C(=O)N3C[C@@H1]4CC[C@H1](C3)N4C(=O)C=5C=NN(C)N=5)=CC=C2O1 CCC=1OC=C(C)C=1C(=O)N[C@@H1](CO)CNC(=O)[C@H1]2CC(=O)N(OC)C2 C=CC1(C(=O)N2C[C@@H1](CNC(=O)C3=CCCS3)O[C@H1]4CCC[C@@H1]42)CCCCC1 CO[C@H1](C)CC(=O)N1CC[C@@H1](NC(=O)C2=CC=C(C(F)F)C=C2Cl)C1(C)C CCCC1=CC=CC=C1NC(=O)C#CC(C)(C)CNC(=O)[C@H1](C)N2C=CC(C)=N2 C[C@H1](CC(=O)NC[C@H1]1C[C@H1]2CC[C@H1]1N2C(=O)C3(O)CCCCCC3)C(F)(F)F COC[C@]1(NC(=O)/C=C/C2=CN=C[NH1]2)CCN(C(=O)C3=CC=NC=C3F)C1 CC1=CC=NC=C1C=CC(=O)NC[C@@H1]2CN(C(=O)C=3C=C(C(C)C)[NH1]N=3)CCO2 CC[C@@H1](CC(C)C)C(=O)NCC(C)=CC(=O)N1CCC[C@H1](F)CC1 CCC[C@@H1](OC)C(=O)N1CCN(C(=O)C2=CN(C)N=C2C)C[C@@H1](O)C1 C=C(CCNC(=O)CCC(C)(F)F)CNC(=O)C1=CC=C(OC)C(OC)=C1C CC(C)C1=CC=C(C(=O)N2CC[C@@H1](C)[C@@H1]2CNC(=O)C3=CC=C(Cl)C(F)=C3)S1 CC1=NN2C=CC=NC2=C1C(=O)N[C@H1]3CCN(C(=O)[C@@H1]4C[C@H1]4[N+1](=O)[O-1])[C@H1]3C C=CC[C@H1](CNC(=O)C[C@@H1]1CCOC1=O)C(=O)N2CC3(C2)CC3(F)F CCN(CC)CC[C@@H1](C)NS(=O)(=O)C1=CC=C(N[C@H1](COC)C(C)C)C(C#N)=C1 C=C(CCNC(=O)C1=CC=C(C(N)=O)O1)CNC(=O)[C@H1](C)C2CC2 C=C[C@@H1](C)CC(=O)N1[C@H1](C(=O)N2CC[C@@]3(CCCOC3)C2)CC[C@H1]1C(C)C CC1=CC(=N[C@H1](C)C[C@H1](C)NC(=O)C[C@H1]2C=CCC2)[NH1]C(CO)=N1 COC1=CC=CC(OCC(=O)N[C@@H1](C)C(C)(C)NC(=O)C[C@H1]2OCCC2(C)C)=C1 C[C@@H1]1CCC2=NC(C(=O)N3CC[C@@](O)(CNC(=O)CSC(C)(C)C)C3)=CN2C1 CC=1C(C(=O)N(C2CC2)[C@H1](C)C(=O)NC3(C4=CC=CC=C4)CC3)=C[NH1]C=1C#N CCOCCNC(=O)[C@@H1](C=1[NH1]N=NC=1C)N(C)C(C2CC2)C3CC3 C[C@@H1](C[C@@H1](C)NC(=O)[C@H1]1CCOC(C)(C)C1)NC(=O)CCC2=NC=CN2C O=C(NC1(CNC(=O)[C@@H1]2CCOC2=O)CCCCC1)C3=CC=C(F)C(F)=C3F CC(C)(C)OC(=O)N1CCC[C@@H1]1[C@@H1]2CCCN(C(=O)CC3=CC=C(O)N=C3)C2 C[C@@H1]1C[C@H1](F)CN1S(=O)(=O)C2=CC=C(NCC3CCCCCCC3)C(F)=C2 C[C@H1]1C[C@@H1](C(=O)NC(C)(C)CCCNC(=O)CCSC2CCCC2)CCS1 C[C@@H1](C(=O)NCC1CCN(CCCOC2=CC=CC=C2Cl)CC1)[C@@H1]3CCOC3 CC(C)[C@@H1]1CCC[C@H1]1C(=O)N2CC3(CCC[C@@H1]3NC(=O)C=CC(=O)N(C)C)C2 CC1=NN=NN1[C@H1](C(=O)NC2C[C@H1](C)N(C(=O)C3CC4(CC(C)C4)C3)CC2)C(C)C C[C@@H1](C(=O)NCCC1CCN(C(=O)C2CCS(=O)CC2)CC1)N3CCC3 O=C(CC1=CC=CC(O)=C1F)N2CC(NC(=O)[C@]34COC[C@H1]3C4(F)F)C2 O=C(O)CCC1=CN(CC(=O)N2CC3=CC=CC=C3C4(COC4)C2)N=N1 CCSC1=CC=CC(N(C)CCC2=COC(C3=CC=CC=C3)=N2)=C1 NC(=O)NC1CCN(C(=O)CC2CN(C(=O)CC3=CC=C(F)C=C3)C2)CC1 C#CCCCCC(=O)N1CC(CNC(=O)C23CC(C[C@@H1](C)O2)C3)(OCC)C1 CC1=NC2=CC=CC=C2N1CC(=O)NC[C@@H1]3C[C@@H1]3CNC(=O)CC4=NN=C(O)S4 COC1=CC=C(C(=O)N2C[C@H1](CNC(=O)C=3C(C)=NOC=3C)C[C@H1]2C)N=C1N C=CC1(C(=O)NC[C@H1](CO)CC(C)C)CCN(C(=O)CCCN(C)C)CC1 C=C1CC(C)(C(=O)N[C@@H1]2C[C@H1]3CN(C(=O)C4=CC=C(CCCC)C=C4)C[C@H1]32)C1 CCN(C(=O)C(=O)N[C@H1](CCN(C)C)C(C)(C)C)C1CC1 CCCCCCCCOCC(=O)N[C@@H1]1C=C[C@H1](CNC(=O)[C@@H1](C)CS(C)(=O)=O)C1 CCN(C)CC=CC(=O)N[C@@]1(CNC(=O)C2CC(F)C2)CCOC1 O=C(NC1=CC=C2OC(O)=NC2=C1)[C@@H1]3C[C@@H1]4C[C@H1]4N3C(=O)C5(C6=CC=CS6)CC5 CCN(CCN1CC=CC1)[C@@H1](C)C(=O)NC=2SC=CC=2C C=CCC1(NC(=O)C=CCOCCOC)CN(C(=O)C=2N=C(C)OC=2OCC)C1 CCN(CCCNC(=O)C[C@@H1]1COCCN1C)C(=O)[C@H1]2CN3CCN2CC3 CCSCC(=O)NCC1(O)CC(NC(=O)C2=CC3=CC(C)=CC(C)=C3[NH1]2)C1 CCCC[C@@H1](O)C(=O)N1C[C@@H1](C)[C@@H1](NC(=O)C2=CN=C(C)[NH1]C2=N)C1 COC(=O)[C@H1]1C=C[C@@H1](C(=O)N2CCN(C(=O)CS(=O)(=O)C3CC3)CC[C@H1]2C)C1 O=C(CCC1=CC=C2N=CSC2=C1)NC3(CNC(=O)C4=CC=C[NH1]4)CC3 CN1C=CN=C1C[C@H1]2CCCN(C(=O)C=3C=NN([C@H1]4CC4(F)F)C=3)C2 CC=1C=CSC=1C(=O)N[C@@H1](C)[C@H1](NC2=NC(C)=CC(C(F)(F)F)=N2)C(C)C CC(=CC(=O)N1CC2(CCC2)C[C@H1]1CNC(=O)[C@H1](C)N3CCCC3)C(F)F CC=C(C)C(=O)NC1(CNC(=O)C2=CC=NC(CC(C)C)=N2)CCOCC1 CC1=NSC=C1[C@@H1](NCC(=O)NC2CC2)C3=NN=NN3C[C@@H1]4CCCO4 C=CC[C@H1](CNC(=O)CN1N=CC=N1)NC(=O)C2=NOC=C2Cl CN(C(=O)C1=CC=C(OC(F)(F)F)N=C1)C2CCN(C(=O)[C@@H1]3C[C@@H1]3Cl)CC2 C[C@H1]1C[C@@H1](CC(=O)NC[C@H1]2CN(C(=O)[C@H1](C)N3CCCC3)CCN2C)CC[C@H1]1C CCN(CCCCO)[C@@H1](C(=O)NCC(F)F)C1=CC=C(F)C(Br)=C1Cl O=C(N1CC[C@@H1]2CN(C(=O)C3=CSC(Br)=N3)C[C@@H1]2C1)C4=COC=N4 CNC1=CN=CC(C(=O)NC2(CCCNC(=O)C3=CC=CC=4SC=CC3=4)CC2)=C1 CCO[C@H1](CC)C(=O)N[C@@H1]1C[C@H1]2C[C@@H1](NC(=O)C=3C(Cl)=N[NH1]C=3C4CC4)[C@H1]2C1 CN1N=C(C(=O)NC2=CC=CC(NC(=O)C3(CC4CCC4)CC3)=C2)C=C1F CC[C@]1(C)CCN(C(=O)C[C@@H1](O)CNC(=O)[C@@H1]2C[C@H1](O)CN2C)C1 C/C=C/CCN[C@@H1](C1=NN=NN1[C@H1](C)CC)C2(N3C=CC=N3)CC2 CC(C(=O)NC/C=C/CNC(=O)C1=C[NH1]N=C1OC(C)C)=C2CC2 CC1=NC=C(Cl)C=C1NC(=O)[C@H1](NC(=O)[C@H1]2CC[C@H1]2C)C3(O)CCCCC3 CCC(C#N)(CC)C(=O)N[C@H1]1CCC[C@H1]1NC(=O)C2=CC(Br)=CC(F)=C2F CC1=NC=C(Br)C=C1C(=O)N[C@H1]2CC[C@@H1](CNC(=O)C3=CC(C#N)=NO3)C2 CN(C(=O)C1=CC=C(Cl)C([N+1](=O)[O-1])=C1)[C@H1]2CCCNC2 O=C(CCC1=NC2=CC=CC=C2[NH1]1)N[C@H1]3C[C@@H1]3CNC(=O)C=4[NH1]C=CC=4C5CC5 C=C[C@@H1](C)CC(=O)N(C)CC1(O)CN(C(=O)C2=CC3=CC=CC([N+1](=O)[O-1])=C3[NH1]2)C1 CCN1CCC(NC(=O)[C@H1]2CC23CCN(C(=O)[C@@H1]4CCCOC4)CC3)CC1 CCC1=CC=C(NC(=O)[C@@]2(NC(=O)CN3C=CN=N3)CCC(C)(C)C2)C=C1 COC=1C=C(C(=O)N2CCOC[C@H1](NC(=O)C3=NC(=O)N(C)[NH1]3)C2)SC=1Cl C[C@@H1](CNC(=O)[C@H1](O)CN1C=NC=N1)NC(=O)[C@H1](C)CC2CCCCC2 CNC=1SN=C(C)C=1C(=O)N(C)C[C@@H1](C)CNC(=O)C=2C=C(OC)N(C)N=2 COC1=CC=C(C2=NOC(C3=NOC4=C3COCC4)=N2)C(Cl)=C1 C[C@H1]1[C@@H1](NC(=O)C2=CC=NC=N2)CCCN1C(=O)C[C@@H1](O)C3=CC=C(Cl)C=C3 CC=CCC(=O)NC(C)(C)CCCC(=O)N[C@@H1](C)C1CCC1 COCCO[C@H1](C)C(=O)N1CC=C(C(C)(C)C(=O)N2CC(OC(=N)O)C2)C1 CC1=CC=C([C@@H1](C)NC=2[NH1]C(=NCC3=CC(C(F)(F)F)=NO3)N=C4SC=NC=24)S1 CC1=NN(C)C=2SC(C(=O)N(C)[C@H1]3CCN(C(=O)[C@@H1]4CCC(C)(C)CO4)C3)=CC1=2 O=C(CSC1=CC=CC=N1)N2CC[C@](O)(CCNC(=O)C3(C4=CC=CS4)CC3)C2 COC1=CC=C([C@@H1](O)C(=O)N[C@H1]2C[C@H1](NCC3=CN=C(Cl)C=N3)C2)C=C1 CC(C)N1CC(N(C)C(=O)CC2=CSC(NC(=O)OC(C)(C)C)=N2)C1 CO[C@H1]1C[C@@H1](NC(=O)C2=N[NH1]C=C2C)CN(C(=O)C3C[C@@H1]4C[C@H1]4C3)C1 NC1=CC=CC([N+1](=O)[O-1])=C1C(=O)N2CC[C@](NC(=O)CN3CCC(=O)NC3=O)C2 O=C(CCCCCN1C=C(C2=CN=CC(Cl)=C2)N=N1)NCCN3N=CC=N3 CC[C@H1](C)OC1=CC=CC=C1C(=O)NCCCCNC(=O)C2=CC(N)=CC(O)=C2 CNC(=O)N[C@H1](C)C(=O)N(C)[C@H1](C)CN(C)C(=O)CC1(C)CCCCC1 CC(=O)NC1=CC=CC(C(=O)N2C[C@@H1](CNC(=O)C3=CC=C(F)O3)C[C@@H1]2C)=C1 CCN1N=CC=C1C(=O)NC[C@@H1]2C[C@H1]3CC[C@H1]2N(C(=O)CSC4=NN=CS4)C3 CCN1C=C(C(=O)N2CCC[C@H1](C3CN(C(=O)C=4SC(=N)[NH1]C=4CC)C3)C2)C=N1 COC1=CC=C(C(C)(C)C(=O)NC[C@@H1]2CC[C@@H1]2NC(=O)C(C)(C)C3CC3)C=C1 CCCNC(=O)[C@H1]([C@@H1]1C[C@H1](OC)O[C@H1]1OC)N2CC[C@@H1](C(F)(F)F)C3(CCC3)C2 [N-1]=[N+1]=NCCCC(=O)NC[C@@H1]1C[C@H1]2CC[C@@H1]1N2C(=O)C34CCCC3CCC4 CCCC(C)(C)C(=O)N1CCN([C@@H1]2CCN(C(=O)[C@@H1](C)OCCOC)C2)CC1 C[C@@]1(O)CCN(CC(=O)NC[C@@H1]2CCCN2C(=O)C3=CCCCO3)C1 CC[C@@](C)(C(N)=O)C(=O)N[C@H1]1C[C@@](F)(CNC(=O)C2(OC=3C=NN(C)C=3)CC2)C1 CC1=C[C@@H1]1C(=O)N[C@H1]2C[C@H1]3C[C@@H1](C2)N(C(=O)CC4=CN=CN4C)C3 C#CCCCCCC(=O)N[C@H1]1C[C@@](C(=O)OC)(C2CC2)C1 O=C(C[C@H1]1C=CCC1)N[C@H1]2CCOCCN(C(=O)C=3N=CSC=3C(F)(F)F)C2 CCO[C@H1](CC)C(=O)N[C@@H1]1CC[C@H1](C)N(C(=O)C2=CC=C(C)C(OCC)=C2)C1 C[C@H1](C(=O)N1CC2(C1)SCC[C@H1]2NC(=O)C3=CC=CO3)C(C)(C)C4=CC=CC=C4 C=C1N=CC(=NC23CCC(CC2)C3)[NH1]C(=NC[C@@H1]4CCOC5=CC=CC=C54)[NH1]C=C1 COC(C)(C)C(=O)NC1=CC=C(C(=O)N2CCC3=CC=CC=C3C2)C=C1O CN(C[C@@H1](O)CNC(=O)C1=CC=CC(S(=O)(=O)C2CC2)=C1)C(=O)[C@H1]3CCOC3 CO[C@]1(C)CCN(C(=O)C2=NC(NC(=O)C3=CC(C)=C(C)C=N3)=CN2CC)C1 CCC[C@@H1](O)CC(=O)N1C[C@@H1](NC(=O)C=C2CCCC2)CC(C)(C)C1 NC(=O)C(=O)N[C@@H1]1CC[C@@H1](CNC(=O)[C@H1]2CC=CCO2)C1 FC1(F)C[C@]1(Br)CN=C2[NH1]C(=NC[C@@H1]3C[C@H1]4C[C@H1]3[C@@H1]5C[C@@H1]45)C6=C(F)C=CC=C6[NH1]2 CC#CCNC(=O)C(C)(C)[C@@H1]1CCCN1C(=O)[C@@H1](C)N2C=NC=N2 CC=1C=C(C(=O)NC[C@@]23CCCN(C(=O)C(C)(C)OC(C)=O)[C@@H1]2C3)SC=1C C[C@H1](C(=O)N1C[C@H1](C2(O)CCC2)C13CCC3)N4C=C(C5=C(Br)C=NN5C)N=N4 CCOCC[C@@H1](NC(=O)C1=CC=C[NH1]1)C(=O)NCCOC2=CC=NC=C2 COCC=1ON=CC=1C2=NC(C34CC5CC(CC(C5)C3)C4)=NN2CCF CC1=CON=C1C(=O)N[C@@H1](CNC(=O)CS(=O)(=O)C(C)(C)C)C2CCC2 CCCSCCC(=O)NC[C@@H1](NC(=O)[C@@H1](C)CC(C)(C)C)C1=CC=C(F)C=C1 CO[C@]1(C(=O)N2CCO[C@@](C)(CNC(=O)CC3CCSCC3)C2)CCC(C)(C)C1 CC1=CC=C(C)C(C(=O)N(C)CCNC(=O)C=2SC=C3C=2OCCO3)=C1O CC1=CSC2=NC(CC(=O)N[C@H1]3C[C@@H1](CNC(=O)CN(C)C(=O)C4CC4)C3)=CN12 O=C(C=C[C@H1]1CCOC1)N2CCN(C(=O)CSC3=CC=CC=C3)[C@H1](CO)C2 CCN(CC)C[C@@H1](C)NC(=O)CN1C=C(C=CC(C)C)N=N1 CC(C)[C@@H1](O)C(=O)N1CCC(F)(F)[C@@H1](CNC(=O)C[C@@H1]2CCOC(C)(C)C2)C1 CCCC1=CC(C(=O)N2CCC[C@H1](N(CCO)C(=O)C3=C[NH1]N=C3F)C2)=NO1 C=CC(C)(C)CNC(=O)NC1=CN=C(C#N)C=N1 CC[C@@H1](C)C(=O)NCC(=O)N[C@H1](CO)C(=O)NC[C@]1(O)CC[C@@H1](C)C1 CC1=CC=C(CN=C2N=C3SC=CC3=C(NC[C@H1]4CCO[C@@H1](C)C4)[NH1]2)C=C1Br C=CC[C@H1](C(=O)N1CCC(F)(CNC(=O)CC2=CC=CC=C2F)CC1)C(C)C CC=1ON=CC=1C(=O)NC[C@H1]2COCCN2C(=O)CC3=CN(C)N=N3 CC1=CC=C(C(=O)NC[C@H1]2CCN(CC3=CC=C([N+1](=O)[O-1])O3)C2)C=C1Cl CC=1C=CSC=1C=CC(=O)N2C[C@H1](NC(=O)[C@H1]3CC[C@@H1](CN(C)C)O3)C(C)(C)C2 COCCN1N=C(C2=CC(SC)=CC=N2)N=C1C=3C=C4N(C=3)CCC4 CC(C)(CNC(=O)C=1C=NN(CC(F)(F)F)N=1)[C@H1]2CCCCN2C(=O)[C@@H1]3C[C@@H1]3F CC=1SN=NC=1C(=O)N[C@@H1]2CN(C(=O)[C@H1](C)CN3C=CN=C3)C4(CCCC4)C2 CC[C@H1](C(=O)N(C)C[C@@]1(C)CCC[C@@H1]1NC(=O)CCCOC(C)=O)N(CC)CC N#CC1=CC(NC23CC(NC(=O)C4=CC=C(CO)C=C4)(C2)C3)=NC=N1 CCCC1(C(=O)NCC(NC(=O)CSCCCC2=CC=CC=C2)C3CC3)CC1 CC(=O)C1=CC(C(=O)N[C@]2(C)CCN(C(=O)[C@H1]3CCC(C)(C)O3)C2)=CS1 NC(=O)[C@@H1]1C[C@@H1]1C(=O)N2CCC(CCCCNC(=O)[C@H1]3CC3(Cl)Cl)CC2 COCCCN1N=NN=C1[C@H1](NC2CC3(CC(O)C3)C2)C4=CC(C)=CC=N4 C=CCCC(=O)N1CCC2(CC1)CC(NC(=O)C=3C=NN(CCO)C=3C(C)C)C2 COC1=CC=CC(C(=O)N2CC[C@H1]3CC[C@@H1](C2)N3C(=O)C4=NSC=C4N)=C1 COC1CCC(C(=O)N[C@H1](C)[C@@H1](CO)NC(=O)CN(C)C(=O)COC)CC1 CC(C)=C(C)C(=O)N1CCN(C(=O)C2=NOC(C)(C)C2)C[C@@H1]1C(C)(C)C COCCS(=O)(=O)CC(=O)N[C@@H1](C(=O)N[C@@H1](C)C1CCC1)C2(O)CCCCC2 CC1=CC=C2C=C(C(=O)N3CC[C@H1](NC(=O)CN4CCCCCC4)C3)N=CN12 C[C@H1](O)[C@H1]1CCN1C(=O)[C@@]23C[C@@H1](CCO2)N(C(=O)[C@@H1]4CCN4C(C)(C)C)C3 CN1N=NN=C1SCCC(=O)NC(C)(C)CNC(=O)CC2=CN=CC(O)=C2 COCC1(CC(=O)N[C@H1]2C[C@@H1](C(=O)NC[C@@H1]3C[C@H1](O)CN3C)C2)CC1 C[C@@H1](O)CC(=O)NC[C@@]12C[C@@H1](CO1)N(C(=O)C3=NC(=N)C=C[NH1]3)C2 CO[C@H1](C)C(=O)N1CCC2(CC1)CC(CNC(=O)C3=C(C)C=CC=C3C)C2 C[C@H1](CCNC(=O)[C@]1(O)CCSC1)NC(=O)C=2C=C3C=CC=CN3N=2 O=C(CS(=O)(=O)NC[C@H1]1CCCO1)N[C@@H1]2CCN(C(=O)C3=CC=NN=C3O)C2 CC1(C)CC(O)(CNC(=NC[C@@H1]2CC23CCC3)NC4CCCC4)C1 CCOC1(C(=O)NCC(C)(C)C#CC(=O)N[C@@H1](C)[C@H1](C)N2C=CC=N2)CCCC1 CN1N=C(C(=O)NC2[C@H1]3[C@@H1](CNC(=O)C[C@H1]4C=CCC4)CC[C@H1]3C2)C=C1O COC1=CC=C(C)C(C(=O)NCC2CN(C(=O)C=3OC(C(F)F)=CC=3C)C2)=C1 C[C@]1(C(=O)NC2C[C@H1](CNC(=O)CSC3=CC=C(Cl)C=C3)O2)CCNC1=O CCCCCCN(C)C(=O)[C@H1]1CC[C@@H1](C2CC2)N1C(=O)CN3C=CC=NC3=O CC1=NSC=C1CC(=O)NCC2(O)CN(C(=O)C=3C=C4N(C=3)CCOC4)C2 CC1=CC(C(=O)N(C)[C@@H1]2CCN(C(=O)CSC(C)(C)C)CC23CC3)=NC(O)=N1 C[C@H1]1[C@H1](C)N(C(=O)CN(C)C2CCCC2)CCN1C(=O)C3=CC=C(O)N=C3Cl CC1=CN(C2=CC=C(F)C=C2)N=C1C(=O)NC[C@@H1]3CN(C(=O)[C@H1](C)CO)CCO3 CCCCC1(NC(=O)[C@@H1]2CN(C(=O)CCCNC(N)=O)C(C)(C)C2)CC1 O=C(CCC12CCC(CC1)C2)NC[C@@H1]3CN(C(=O)[C@H1]4CCCC[C@@H1]4F)CCO3 C[C@H1](O)C=1N=C(CCCCCCCC2CC2)N(C3=CC=C(F)C=C3)N=1 CCN(CC)C(=O)CN(C)C(=O)[C@H1](CC[C@@H1]1CCCOC1)NC(=O)OC(C)(C)C CN(C[C@H1]1CCCN(C2=NC=CC=N2)C1)C(=O)CCC3=CC=CC(F)=C3 CNS(=O)(=O)CC(=O)NCCN(C[C@@H1](C)O)C(=O)[C@@H1](C=1C=C[NH1]N=1)C(C)(C)C C[C@@H1](CCNC(=O)C[C@H1]1[C@@H1]2CN(C(=O)CC3=CC=CC(C#N)=C3)C[C@H1]12)C(C)(C)C C=CCN(CCC(=O)OC)C(=O)C1(N(C)C(=O)[C@H1]2CC(C)=NO2)CC1 CCCN1N=CC(C(=O)N2CC[C@H1](C)[C@@H1](NC(=O)CC3CCC(C)CC3)C2)=C1C COC1=CC=C(CCNC(=O)C2=NC(C(=O)N=C3N=N[NH1][NH1]3)=CS2)C=C1F COC1=CC(I)=CC=C1C(=O)N2CC3(C[C@H1]3C(=O)NC4CC(F)(F)C4)C2 C[C@](O)(CNC(=O)C=C1CCOCC1)CNC(=O)CC2=CC=C3N=CSC3=C2 CO[C@@](C)(CO)C(=O)N[C@H1]1C[C@H1](CNC(=O)C2=CN(C)[NH1]C2=N)C1 CCN1CCN(C(=O)[C@H1]2CCCN(C(=O)[C@H1]3C[C@@H1]3C4=CC=C(I)C=C4)C2)CC1 CSC1=CC=CC=C1CC(=O)N[C@H1](C(C)C)[C@H1](C)NC(=O)CSC CCOCC(C)(C)C(=O)N(C)C[C@H1]1CCCN1C(=O)CCCC#N COC1=NC(C)=CC(=NC[C@H1]2CN(C(=O)C=3C=CN(C)N=3)CC[C@H1]2C(F)(F)F)[NH1]1 CC1=NC(C2=CN([C@@H1](C)CNC(=O)[C@@H1](C)CC=3C(C)=NOC=3C)N=N2)=CS1 C/C=C/C[C@H1](C)C(=O)N1C[C@H1](C)O[C@]2(CCN(C(=O)C3=C[NH1]C(=N)O3)C2)C1 C[C@H1](NC(=O)[C@H1](C)N1C=NC=N1)C2CN(C(=O)CC3=CSC=N3)C2 C=CC(C)(C)CCCNC(=O)[C@@H1](CCC(C)C)NC(=O)C[C@@]1(C)CCOC1 CC[C@H1](COC)N(C)C(=O)C[C@]1(C)CCN1C(=O)[C@@H1](C)NC(=O)OC CCC1=CC=C(C(=O)N(CC)CCN2C=C(COC3=CC=C(F)C=C3)N=N2)N=C1 O=C(NCCN1CCN(C(=O)[C@H1]2CCCCC3=CC=CC=C32)CC1)C4=CN=N[NH1]4 CO[C@@]1(C(=O)NCC=2N=COC=2C)CCN(C(=O)CCOC(C)C)C1 CC[C@@H1](C)C[C@@H1](NC(=O)C1=CC(C)=NC(C)=C1)C(=O)N[C@H1]2C[C@@H1](CO)[C@@H1]3C[C@H1]23 CC1=CC[C@H1](C(=O)N[C@@H1]2COC[C@@H1]2NC(=O)C3=CC4=CC=CN=C4C=N3)CC1 CCN1C=C([C@@H1](C)N=C2[NH1]C(N3CCC[C@H1](C)CC3)=NC4=CC=CC=C24)C=N1 CC=C[C@H1](O)C(=O)N1C[C@H1](NC(=O)C2=CN=C(N3C=CC=N3)C=N2)CC14CCC4 CC1(C)[C@H1](O)[C@H1](O)CN1S(=O)(=O)C2=CN=NS2 COCC[C@@H1](CNC(=O)C1CN(C(N)=O)C1)NC(=O)C=2N=C[NH1]C=2C(C)(C)C CN(C(=O)CC1=CC=C2C(=N1)NCCC2)[C@H1](C(N)=O)C3=CC=CC(F)=C3 CC1=CN=CC(CC(=O)N[C@@H1](CC(=O)N[C@@H1](C)C2=CSN=N2)C(F)F)=C1 C#CC1=CN=CC([C@H1](C(=O)NC2COC2)N(CC(=O)OC)CC(F)F)=C1 C#CC1=CC=C(C(=O)N[C@@H1](C)CC2CN(C(=O)C(C)(C)CS(N)(=O)=O)C2)C(C)=C1 COC1=CC=CC(NC(=O)C2=CC3=C(S2)CCN(CC4=CC(Br)=CC=C4O)C3)=C1 CC1=CC=CC(CCN2CC[C@H1](O)[C@H1](CO)CC2)=N1 CN1C(=O)CC[C@H1](NC(=O)[C@H1]2CCN(C(=O)C[C@H1]3C[C@H1]4CC[C@@H1]3O4)CC2(C)C)C1 CCCC1CC(C(=O)N[C@@H1](CCOCCO)C(=O)N[C@H1]2CC(C)(C)OC2=O)C1 CCC(CC)[C@@H1](C)C(=O)NCCCCC1CCN(C(=O)COCCC(C)C)CC1 O=C(NC1CC(CCNC2=NC=C(C(F)F)C=N2)C1)C3=CC=CC=[N+1]3[O-1] CCC(=O)NCCNC(=O)[C@@H1](O)CCCNC(=O)C=1OC=NC=1C2CC2 CC[C@@H1](CNC(=O)[C@H1](C)C=1C=C(C)OC=1C)NC(=O)C(F)=C(C)C CN1CCC(CC(=O)NC[C@@H1](CC(F)(F)F)NC(=O)CSC=2C=NN(C)C=2)CC1 CC1=NSC(C(=O)NC2=CC=C(Br)C(N3N=C(C)C=C3C)=C2)=C1Br C=C1C[C@@H1](C(=O)N2CCC3(CC3)C2)N(CC4=CC=C5C=NN(C)C5=C4)C1 CCN(CC)CCC(=O)N1CC(O)([C@@H1](C)NC(=O)[C@H1]2CC[C@H1]3C[C@H1]3CC2)C1 CN(C)C[C@H1](C(=O)N[C@@H1]1CN(C(=O)C2=CC=CC3=CC=NN23)C(C)(C)C1)N(C)C CO[C@@]1(CNC(=O)C=CCO)CCN(C(=O)C[C@@H1]2CC(=O)NC3=CC=CC=C32)C1 C[C@H1](CC(=O)N1CCC(C2(NC(=O)CCC3=N[NH1]C(=N)S3)CC2)CC1)C4CC4 CON=CC(=O)N(C)[C@@H1]1CCC[C@@H1]2CN(C(=O)COC=3C=NN(C)C=3)C[C@H1]21 CCC(F)(F)C(=O)N1CC[C@]2(CCC[C@H1]2NC(=O)C=3C=C4C=CC=NN4C=3)C1 O=C(CCC(=O)NC1CCCC1)NC[C@@H1]2C[C@H1]2CNC(=O)CC3CCCCC3 O=C(NC[C@H1]1C[C@@H1]2CC[C@H1](C1)N2C(=O)C3=CC(O)=CS3)[C@@H1]4CC5=CC=NC=C5C4 C[C@H1](CC(=O)NC[C@H1](O)CNC(=O)C=1C=NN(C(C)(C)C)C=1)CC(F)(F)F CCOC(=O)C=CC(=O)N1CCCC[C@H1]1CNC(=O)C[C@H1](C)[C@H1](C)C(C)C CN(C)[C@@H1](C(=O)N1CCCN(C(=O)[C@@]2(C)CCCO2)CC1)C(C)(C)C CCCC=C(CC)C(=O)NCC[C@H1](C)NC(=O)C1=CC=CC(N)=C1OC(C)C C=CCCC(C)(C)NC(=O)[C@@]1(NC(=O)CC2(OC)CCC2)CCC(C)(C)C1 COC1=NSC=C1C2=CN([C@H1]CCCN(C(=O)C3(C=4C=CN(C)N=4)CC3)C)N=N2 CSC1=CC=CC(C(=O)N[C@@H1]2C[C@H1]2C(=O)N3[C@@H1](C)CC[C@H1]3CO)=C1 O=C(NC[C@@H1]1CCCCN1C(=O)CC2(O)CCCCC2)C3=CC4=CN=CC=C4O3 CC(C)C[C@@H1](C(=O)N1CC[C@]2(C[C@@H1]2C(=O)NC[C@@H1]3CCC[C@H1](CO)C3)C1)C(C)C CCC1CN(CC(=O)N(C)C[C@@H1](CC)NC(=O)[C@@H1]2CCC(F)(F)CC2(C)C)C1 C[C@@H1]1C[C@H1](NC(=O)C=2SC=NC=2Cl)CN1C(=O)C=3C=CN(C4CCCC4)N=3 CC(C)[C@@H1](O)C(=O)NCC1(CC(=O)NC2=CC=C(F)C(CO)=C2)CC1 C[C@H1]1CCCN1CC(=O)N2CC[C@](C(=O)NCCC3CC(F)(F)C3)(C(C)C)C2 CCO[C@H1](C(=O)N[C@H1](C)C1(O)CCN(C(=O)CN2C=CC=C2)CC1)C(C)C CC(C)[C@@H1]1C[C@@H1](CC(=O)N[C@]2(C)CCN(C(=O)[C@@H1]3CCC3(C)C)C2)CCO1 CCOC(=O)[C@H1](NC(=O)[C@H1](NC(=O)[C@@H1](C)OCC1CC1)C2=CC=CS2)C3CC3 C[C@@H1]1CC(C(=O)N2CCOC[C@@H1](C(=O)N(C)[C@H1]3CCCNC3=O)C2)=NO1 CC(C)(C)OC(=O)NCC1(COC(=O)[C@@H1]2C[C@@H1]3C[C@H1]2CO3)CCOCC1 CN1CCC[C@@H1]1C(=O)N2CCN(C(=O)[C@@](C)(F)CC3CCCC3)CC4(CC4)C2 COCCC1(NC(=O)C2=CN=C3[NH1]C=NC=C23)CCN(CCCCCF)CC1 CCOCCC(=O)NC[C@H1]1CC[C@@](F)(CNC(=O)C2=CN=C3[NH1]C=NC3=C2)CC1 CC(C)OC(C)(C)C(=O)N[C@H1]1CN(C(=O)C[C@@]2(C)CCS(=O)(=O)N2)C[C@@H1]3C[C@@H1]31 COCCN1C=CC(C(=O)NCCCCCN2CCN(C(=O)CSC(C)C)CC2)=N1 O=C(CCOCC(F)F)NCC1(O)CCN(C(=O)C2=CC=NN3C=CN=C23)CC1 CCC[C@H1](CNC(=O)CC1=NC=C(C)S1)NC(=O)C2=C(OC)C=CN=C2O COC[C@@]1(C(=O)NC[C@@H1]2CCN(C(=O)C3=CC=C(C)O3)C2)CC1(F)F CSCCC(=O)N[C@@]12CCC[C@H1]1CN(C(=O)C=CC3=NC=C[NH1]3)C2 C[C@@H1](CN(C)C(=O)CCCC1=CC=CC=N1)N(C)C(=O)C2=CN=CC(F)=C2 CC(=O)C1=CC=C(C(=O)N(C)[C@@H1]2CCCN(C(=O)[C@]3(F)CCOC3)C2)C=C1O O=C(NCCC1COC1)N2C[C@@H1](S)CC23CCC3 CCCC[C@H1](CC)CC(=O)N1CC[C@@H1](NC(=O)CCCCOC)[C@H1](CC)C1 CCO[C@@H1]1CCCN([C@@H1](C(=O)NC2CCCC2)[C@H1](C)CCC(=O)OC)C1 CCC=1N=C(C)OC=1C(=O)NC2CCN(CC3=CC=C(C)C=C3)CC2 COC(=O)C=1C=CN(CC(=O)N2C[C@@H1](O)[C@@H1](CNC(=O)[C@@]3(C)C=CCC3)C2)N=1 CCC1C=C(C(=O)N[C@@H1]2[C@H1]3CCN(C(=O)C=CCSC(C)=N)[C@H1]32)C=NN1C C#CCCC[C@@H1](C)C(=O)NCC1CCN(C(=O)C2=CC(C)=CN=C2N)CC1 C[C@@H1](CN(C)C(=O)[C@H1](C)OCC1=CC=NC=C1)NC(=O)C(F)F CCCC[C@H1](NC(=O)[C@@](C)(F)C(C)(C)F)C(=O)N(CCCO)OC N#C[C@@]1(C(=O)N2CC=C(CNC(=O)CC3=CC=CC=C3OC(F)F)CC2)CCC1 CC1=NC(N[C@@H1]2CCCN3C=NN=C32)=CC(=NC[C@H1]4CSCCS4)[NH1]1 COC1=CN=CC=C1C(=O)N[C@@H1](C)[C@@H1]2C[C@H1]2C(=O)N3CCO[C@H1]4C[C@@H1]43 O=C(N[C@@H1]1CN(C(=O)C2=CN=C(O)O2)[C@@H1]3C[C@@H1]13)C4=C[NH1]N=C4OCC(F)F CCO[C@@H1](C(=O)N1C[C@@H1](NC(=O)C2=NOC3=NC=CC=C23)C4(CC4)C1)C(C)C CCC=1N=C(C)[NH1]C=1C(=O)N[C@@H1]2[C@H1]3C[C@@H1]2N(C(=O)C4=CC(Cl)=CC(Cl)=C4O)C3 C=CC[C@@H1](OC)C(=O)N1C[C@H1](NC(=O)CNC(=O)CC)[C@@H1](SC)C1 CC[C@@](C)(CNC(=O)[C@H1](SC)C(C)C)C(=O)N[C@H1]1[C@H1](O)[C@H1](O)C[C@H1]1O COC1=C(Cl)C=CC=C1C(=O)N2C[C@@H1]3C[C@@]3(CNCC4=CC=NC(Cl)=C4F)C2 CCOCCC(=O)NC[C@@H1](CCOC)NC(=O)[C@@H1]1CCC[C@H1](C(N)=O)C1 COCCCC(=O)N(C)C[C@H1](O)CNC(=O)C1=CC2=CC=C(C(=O)OC)C=C2[NH1]1 CCC1CCC(N(C)C(=O)[C@H1](CN(C)C)NC(=O)[C@@H1](CC)COC)CC1 C[C@@H1](F)CC(=O)NC[C@H1](O)CCNC(=O)C1(OC2=CC=CC=C2F)CC1 C[C@H1](O)[C@H1](C)CNC(=O)C1=CC=C(CNC(=O)[C@@H1](C)S(C)(=O)=O)O1 CCC[C@H1](C)CN(C)C1=CC=C(F)C=C1CN(C(C)=O)C2CC2 O=C(CN1CCC[C@H1](C2CCN(C(=O)C3=CC=NS3)CC2)C1)NC4CCCCC4 C[C@@H1]1CCC(C)(C)CN1C(=O)CCCCCNC(=O)C=2C=C(O)N(C)N=2 CC[C@H1](C)N1N=NN=C1C2(NC3(COC)CCCCC3)CC4(CC4)C2 C[C@@H1](C(=O)N1CCCC[C@@H1]1CN(C)C(=O)CC2=CSC(S)=N2)C3=CC=C(N)C=N3 O=C(CCCCCCCCCO)N[C@@H1]1COCC[C@@H1]1NC(=O)C2CCS(=O)CC2 CCOC1=NN=C(CN2CCC([C@H1](C)NC(=O)[C@H1]3C[C@H1]3)CC2)S1 COCC[C@@H1]1CN(C(=O)C2=CC(OC)=CC=C2OC)CCN1C(=O)[C@H1](O)C(C)C COCC1=CC=CC(C(=O)NCC23CC(NC(=O)C=4SC(=N)[NH1]C=4C)(C2)C3)=C1C C[C@H1]1[C@@H1](C2=CC=CC=C2)CCN1C(=O)C(=O)CCC(=O)C3=CC=C(Br)C=C3 CC[C@@H1]1C[C@H1]1CC(=O)NC[C@@H1]2COC(C)(C)CN2C(=O)CCC(C)(C)C#N CCCCC(CCCC)C(=O)N[C@@H1](C)CNC(=O)[C@H1](CC)N1CCCC1=O C=CCN1C=C(C(=O)N[C@H1](CO)CCCNC(=O)C2(OCC)CCC2)C=N1 CP(C)(=O)CCC(=O)N1CCN(CCCNC(=O)[C@@H1]2C[C@@H1]3CCCCC[C@@H1]32)CC1 C[C@H1](C[C@@H1](C)NC(=O)C[C@H1](O)CC(C)(C)C)NC(=O)CCC1=CC=NC=N1 CC[C@@H1](CC(C)C)C(=O)N1C[C@H1](N(C)C(=O)CC=C(Cl)Cl)C2(CC2)C1 CCCC[C@H1](C)CCC(=O)N[C@@H1](CNC(=O)C#C[C@@]1(C)CCCO1)C(C)C O=C(NC1=C(O)C=CC=C1Br)[C@@H1]2C[C@@H1](O)CN2C=3C=CN4N=CC=C4N=3 CC1=NSC(C)=C1C(=O)NC[C@H1]2COCCN2C(=O)C=3C=C(Br)N(C)C=3 O=C(C=1C=CC2=NC(C3CC3)=CN2C=1)N4CC[C@H1]4CCO CC(C)C=1C=C(CN2CCC[C@@H1](NC(=O)[C@@H1]3C4C[C@@H1]5C3[C@@H1]5C4)C2)ON=1 CC1=CC=NC(C(=O)N2C[C@H1]3C[C@@]3(C(=O)NC[C@H1]4C[C@@H1](O)CC5[NH1]C=CC45)C2)=N1 COC1=CC(C)=CC=C1C2=NC(CCNC(=O)N3CCOCC3)=CO2 CCC1=CC=C(C(=O)NCC[C@H1]2CC[C@@H1](NC(=O)C3=CN4N=CC=CC4=N3)C2)[NH1]1 CC(C)=CCCC(=O)NCC1=CCN(C(=O)CC=2C=NOC=2)CC1 CCOC=1C=C(C(=O)NC[C@@](C)(CO)NC(=O)C2=CN=C(C(C)(C)C)[NH1]2)[NH1]N=1 CC1(C)CN([C@](C)(C(=O)NC2=CC=CC=C2)N3CCC[C@H1](O)C3)C[C@H1](CCO)O1 C=C(C)C(C)(C)C(=O)N1CC[C@@H1](NC(=O)CC2=CC=CC=C2C(C)C)[C@@H1](CO)C1 C[C@@H1]1C[C@H1]1C2=CC=C(C(=O)N(C)CC3CN(C(=O)C4=CC=CC=C4O)C3)O2 C[C@]1(CC(=O)NC[C@@H1]2C[C@H1]2NC(=O)C3=C[NH1]N=C3N4C=NN=N4)CC1(F)F CCNC(=O)[C@@H1]1CCCN(C2=NC3=C(F)C=C(F)C=C3C(=NCC4(F)CC4)[NH1]2)C1 C[C@H1](CN(C)C(=O)C1(NC2=NC=CS2)CCCCC1)NC(=O)[C@H1](O)CC3CC3 C=C1CC(C(=O)N[C@@H1]2CCN(C(=O)CC3=CN(C)C=N3)[C@H1](C)C2)C1 CC(=O)C1=CC(NC(=O)[C@H1]2CC23CN(C(=O)C(C)(C)F)C3)=CC=C1O O=C(C=1C=C2C=C(Cl)C=CN2N=1)N3C[C@@H1]4CCCN(C(=O)C5=CCCCO5)[C@@H1]4C3 CC1=NC(N2CCN(C(=O)[C@H1]3CCO[C@@H1](C(C)C)C3)C4(CC4)C2)=CC=C1[N+1](=O)[O-1] CC(=O)N[C@H1](C)C(=O)N[C@]1(CF)CCN(C(=O)C=2N=C3N=CC=C(C)N3N=2)C1 CC1=CC(C)=CC(C2(C(=O)N3C[C@@H1](NC(=O)CCC#N)[C@H1](CC4CC4)C3)CC2)=C1 C=C=C(C)CC(=O)N1CCN(C(=O)[C@@H1]2CCCN(C(=O)CC(=C)C)C2)C[C@H1](O)C1 CC(C)[C@@H1](O)C(=O)N[C@@H1]1[C@@H1]2C[C@H1]3[C@@H1](C2)CN(C(=O)CCCCNC(N)=O)[C@H1]31 CC1(C)C[C@H1](NC(=O)C2=CC=C3N=C[NH1]C3=N2)CN1C(=O)CC4=CN=NS4 O=C(NC[C@H1]1[C@@H1]2CN(C(=O)CN3C=NN=C3)C[C@H1]12)C4=CC=C(Br)C=C4 CC(C)CCCCC(=O)N[C@H1](CO)[C@@H1](C)NC(=O)[C@H1]1C[C@@H1]2CC[C@H1](C1)S2(=O)=O CCSCC(=O)NC[C@H1]1C[C@@H1]1NC(=O)C2=CN(CC)C3=CC=CC=C23 C#CC[C@H1]1CN(C(=O)[C@@H1](C(C)C)[C@@H1](C)NC(=O)CC2CCCC2)CCO1 CC1=CC=C(NC(=O)CNC(=O)C2=CC=CC3=NN(C)C=C23)C=C1C#N CC1=CN=CC(CCC(=O)N[C@@]2(CNC(=O)C34CC3C4)C[C@H1]5CC[C@H1]2C5)=C1 CC1=CN=C(N2C[C@H1]3CCN(C(=O)C4=C[NH1]C(=O)C=N4)C[C@H1]3C2)N=C1C CC[C@@H1](COC)N(C)C(=O)[C@@H1](CNC(=O)C=CC(C)C)N(C)C CCC1=CC(F)=CC(CN[C@H1]2CCC[C@@H1](C)C2)=C1 CC1(C)C[C@@H1](NC(=O)[C@]2(C)CCCO2)CCN(C(=O)C=3C=NN4N=CC=CC=34)C1 C[C@@H1]1CN(C(=O)CCN2C=CC=NC2=O)C[C@H1]1NC(=O)C3=C(O)C=C(O)C=C3O COC1=CC(SC)=CC=C1C(=O)N(C)CCN2C=C(C(C)(C)CO)N=N2 CC=1C=C(C)N2N=C(CNC(=NCCF)N(C)CC3=CN(C)C=N3)N=C2N=1 COC(=O)/C=C/C1=CC=C(CN2CCC[C@@H1](NC(=O)C=3C=C(C)ON=3)CC2)C=C1 CC1=C(C(=O)N[C@@H1]2CN(C(=O)C3(CC(F)F)CCC3)C[C@H1]2O)C=CC(F)=C1F COCC[C@H1]1C[C@@H1]1C(=O)NCC(C)(C)CC(=O)N[C@H1](C)C2=CC=C(F)C=C2 C#C[C@H1]1CN(C(=O)C[C@H1]2C[C@H1](NC(=O)C3=CC=CC4=CC=NN34)C2)CCN1C CC[C@@H1](CC(=O)NC1(C)CN(C(=O)[C@@H1](C)C2=NC(C)=CS2)C1)OC CC=1C=CSC=1C(=O)N2CC[C@@H1](C)[C@@H1](NC(=O)C=3C=CC(=O)N4C=3CCCC4)C2 CC(C)(CNC(=O)CN1CCS(=O)(=O)CC1)NC(=O)C2=COCCC2 CO[C@@H1](C(C)C)[C@H1](O)C(=O)N(C)CCCCC(=O)N(C)CC1=CC=CC=C1F C#CC1=CC=C(C(=O)N2CC([C@H1]3CCCCN(C(=O)C4(SC)CC4)C3)C2)C=C1C CC1=CC(C)=C(C(=O)N(C)[C@H1]2CC[C@H1](CNC(=O)/C=C/C3=CC=C(Cl)S3)CC2)[NH1]1 CS[C@H1](C)CC(=O)N1CC(CNC(=O)[C@H1](OCC(C)C)C(C)C)(C(N)=O)C1 CCCN1C[C@@H1](C(=O)N2CC[C@@](C)(CNC(=O)C3CCCCCC3)C2)CC1=O CC=C(F)C(=O)NC[C@@H1]1CN(C)CCN1C(=O)C23C4C5C2C6C3C4C56CO C=CCN1C=CC=C1C(=O)NC[C@@H1]2CN(C(=O)C3=CC=C(O)N=N3)C[C@H1]2C COC(C)(C)CCC(=O)N1CCOC[C@H1]1CC(=O)N2CC(OCC(N)=O)C2 CN(C)[C@H1]1C[C@H1](C(=O)N2CCC[C@]3(NC(=O)[C@H1]4CC=CCC4)C[C@@H1]3C2)C1 CC[C@H1](C)OC1=CC=C(CN(C)C(=O)C2=CN=C(S)N=C2O)C=C1 C=CCOCCCC(=O)NCC(C)(C)C1(O)CN(C(=O)[C@H1](CC=C)C(C)(C)C)C1 COC1=CC=C(C(=O)N[C@H1]2CCN(C(=O)C=3SC(Cl)=CC=3Cl)C[C@@H1]2CO)C=N1 CCC(C)(C)CCCC(=O)NCCCN(C)CCCCNC(=O)[C@H1]1CCC[C@@H1]1O CC[C@H1](C(=O)N1C[C@@H1]2C[C@H1]3C[C@H1]2[C@H1]1[C@H1]3NC(=O)CC4=CSC5=NC=CN45)N(C)C N#CCS(=O)(=O)N1C[C@H1]2[C@@H1]([C@H1]1C(=O)NC3=NC=CC=4[NH1]C=CC3=4)C2(F)F CC1=NN(CC(C)C)C(Cl)=C1CN(CCO)[C@@H1]2CCS(=O)(=O)C2 CC1=CC(CNC(=O)CC[C@H1]2CCCN(C(=O)C3=CC(Cl)=NO3)C2)=NN1C CC(=O)N(C)CC(=O)N1[C@@H1]2CN(C(=O)[C@@H1]3C[C@H1]4CCCCCC[C@H1]43)C[C@@H1]2C[C@H1]1C CCNS(=O)(=O)CC(=O)N(C)CCNC(=O)[C@]1(C)CO[C@H1](C)CO1 C[C@@H1]1[C@H1](C(=O)N2CCOC[C@H1](NC(=O)C3=CC=4OC=CC=4N3C)C2)CCN1C CC[C@H1](C(=O)N[C@@](C)(CO)CNC(=O)CN=S(C)(C)=O)C1(O)CCCCC1 CCC(CC)NC(=O)[C@@H1]1C[C@@H1](O)CN1C(=O)C2=CC(OC)=CC=C2C CC1=CC(CC(=O)N2[C@H1](C(=O)N[C@@H1](CCC3CC3)C(C)(C)C)C[C@H1]4C[C@H1]42)=N[NH1]1 O=C(CC1=CC=CC([N+1](=O)[O-1])=C1)NCC2CC(N=C3C=CN=C(C4CC4)[NH1]3)C2 C=CCSCC(=O)N1[C@H1]2CC[C@@H1]1[C@H1](C(=O)N3C[C@H1]4OC(=O)O[C@H1]4CO3)C2 C[C@H1](CC1=CC=CC=C1)C(=O)N(C)CCOCCCN(C)C(=O)[C@H1]2C=CCC2 CCC[C@H1](C#N)C(=O)N1CC[C@@H1]2C[C@@]21C(=O)NCC[C@@H1]3CC(C)=NO3 C[C@H1]1CN(C(=O)C2=CC3=NC=CN3C(O)=N2)C[C@H1]1NC(=O)C4=CC=C(CO)O4 CSC1=NC=C(C(=O)N2CC[C@@](C)(NC(=O)C3CN([C@H1]4CCOC4)C3)C2)N1C CC(C)(O)[C@@H1](F)C(=O)N1CC[C@@H1](NC(=O)CC[C@@H1](N)C(N)=O)C1 CC[C@H1]1CN(C(=O)CC2=CN=CN=C2)C[C@@H1]1C(=O)N[C@@H1]3CCCC4=C[NH1]N=C43 C[C@@H1]1CCN(C(=O)CC#N)C[C@H1]1NC(=O)C2(F)CC2(F)F CC[C@H1](CCC(=O)N(C)[C@H1]1COC[C@H1]1OC)NC(=O)CNC(=O)C2CC2 CCCC(=O)N1CSC[C@@H1]1C(=O)N2C[C@H1](C)[C@H1](NC(=O)C3=CN4C=CN=C4S3)C2 CO[C@H1]1CN(CC2=CC=C(F)C(C#N)=C2)C[C@H1]1NC(=O)C3=CC(O)=CC=C3Cl CN1CC(CC(=O)NCCCCCN(C)C(=O)C[C@@H1]2CCOC2)C1 CC1=C(C(=O)N(C)CC(C)(C)NC2=NC(Cl)=C3C(=N2)COC3)C=CC4=CN=CN14 O=C(C1=CN=N[NH1]1)N2CC[C@]3(CCCN3C(=O)C4=CN=CC(Cl)=C4)C2 CC(C)OC=1C=C(NC(=O)C2CN(C(=O)C3=CN=NC(O)=C3)C2)[NH1]N=1 CSC(C)(C)C(=O)N[C@@H1]1CS(=O)(=O)C[C@H1]1NC(=O)CCC2=C(F)C=CC=C2Cl O=C(C=1C=CSC=1)N2C[C@H1]3C[C@H1]2C[C@@H1]3N4CCC5=NC=NC=C5C4 CN(CC[C@H1](O)CO)[C@@H1](C(=O)NC[C@@H1]1CCCO1)C2=NC(Cl)=CC=C2Cl CC(C)(C(=O)NCC1=CC(C(=O)N2CCC3=NC=CN=C3C2)=CS1)C4CC4 CCC=1OC=NC=1C(=O)N2CC[C@@H1](NC(=O)CC3(C)CC3)C2 CC1=CC=C2SC(C(=O)N[C@H1]3C[C@H1](C)N(C(=O)CC4=COC(C)=N4)C3)=CC2=C1 CC1=NN=NN1CC(=O)N2CC(F)(F)C[C@H1]2CCNC(=O)CC3CC(F)C3 CO[C@@H1](C)CC(=O)N1CC(OCCC(=O)NCC[C@@H1]2C[C@H1]2C)C1 CN1C(C(=O)NCC[C@H1]2CC(F)(F)CN2C(=O)C34CCC3CC4)=CN=C1Cl CCCC(=O)NC[C@H1](C)CN(C)C(=O)[C@@H1]1CCC2(CCOCC2)O1 CC1(C)C[C@H1](NC(=O)[C@H1](O)CCCNC(=O)CC=2C=CON=2)CCO1 CCC[C@@H1](CCCNC(=O)C1=NC=CC=C1F)NC(=O)C2(C#N)CC(=O)C2 N#CC1=CC=C(S(=O)(=O)N[C@H1](CC2=CC=CC=N2)C(=O)O)C(Cl)=C1 CC(C)(O)C1=CC=NC(C(=O)N[C@@H1]2CCC[C@H1]2NC(=O)C3=CC=CS3)=C1 CC[C@](C)(OC)C(=O)NC[C@@]1(F)CCN(C(=O)CN2C=CC(=O)C=C2C)C1 COCC1=NC(N[C@@H1](C)C[C@H1](C)O)=CC(=NCC2=NC=CN2C3=CC=CC=C3)[NH1]1 CCO/C=C/C(=O)N1C[C@@H1]2CC[C@H1](C1)N2CC3=C(O)C=C(O)C=C3O O=C(NCCO[C@H1]1CCN(C(=O)CCOC2CCC2)C13CC3)[C@@H1]4C[C@@H1]5O[C@H1]4[C@H1]6C[C@@H1]56 C[C@H1](CC(=O)NC1C[C@@H1]2CC[C@H1](C1)N2C(=O)CSCCC#N)CC(F)(F)F CC1=NOC(C)=C1CC(=O)N2CC[C@@H1](F)[C@@H1](NC(=O)CN3CCCC3=O)C2 COC=1C=C(C)SC=1C(=O)N(C)C[C@H1]2CCC[C@H1]2NC(=O)C3=C(C)CCOC3 CC1=C(C#N)C=CC=C1C(=O)NC2CC(CNC(=O)[C@H1]3[C@@H1](O)C(=O)N(C)[C@@H1]3C)C2 CCC[C@H1](CC)CC(=O)N(C)CC1CN(C(=O)C2=CC(Cl)=C(O)C=C2C)C1 COC=1C=C(C(=O)N2C[C@@H1](O)[C@H1](N(C)C(=O)CC=C(Cl)Cl)C2)N(C)N=1 CC=C(CC)C(=O)N[C@@H1]1C[C@H1]1NC(=O)C2=CC=C(S(=O)(=O)NC3CC3)C=C2 CCN(C(=O)CCOC1COC1)[C@H1]2CCCN(C(=O)[C@H1]3CCCC34CCC4)C2 COC1=CC2=C(C=C1Cl)CCN(C(=O)[C@]3(C)CCCO3)C2 C[C@H1](OC1=CC=CC=C1)C(=O)N2CC[C@H1](CO)[C@H1](NC(=O)CCN3C=CN=N3)C2 CC[C@@H1](CCOC)C(=O)NCC1(CNC(=O)C2=CC=C(Cl)S2)CCC1 CC(C)C=1N=NSC=1C(=O)N2C[C@H1](CNC(=O)[C@@H1]3CCC34CCC4)OC(C)(C)C2 C[C@@H1]1[C@@H1](NC(=O)[C@H1](C)CCO)CCCN1C(=O)C2=NC=NC3=C2C=NN3C CC1(C)C[C@@H1]1CC(=O)N[C@](C)(CNC(=O)C2=CC=CN=C2F)C3CC3 C=CCC1(C(=O)NC2([C@H1]3CCCN(C(=O)[C@@H1]4CC[C@@H1](O)C4)C3)CC2)CCOCC1 CC1=NC(CNC(=O)CC2CC3(C2)CN(CC4=CC(Cl)=C(Cl)C=C4O)C3)=NO1 COC[C@@]1(C(=O)N2CCC(CN(C)C(=O)CN3C=CC(=N)[NH1]3)CC2)CCC(=O)N1 CC1=CC=C(C)C(SCC(=O)OC2=CC=C(Cl)N=C2C3=CC=C(C)O3)=C1 CC1=CC=CC(C2(O)CN(N3CCCC[C@H1]3C4=CC=C(F)C=C4F)C2)=C1 CC1(C)C[C@@H1]1CCC(=O)N2CC[C@H1](NC(=O)CNC(=O)C3=CC=NC=C3)[C@H1](O)C2 C[C@@H1](NC1=CC=C(Cl)C=C1Cl)C(=O)N(C)CCNC(=O)C2=NOCC2 COCC=1C=C(C(=O)NCCCCC2CN(C(=O)C[C@@H1]3CCCS3(=O)=O)C2)ON=1 CC(=O)C1=CC=CN=C1N[C@H1](CNC(=O)C2=CN=C(CO)N=C2C)[C@H1](C)C(C)C C[C@H1](C(=O)NC1(C2CN(C(=O)CNS(C)(=O)=O)C2)CC1)C3=NC(F)=CC=C3Cl CSCCC(C)(C)C(=O)N1CC(=O)C[C@@H1]1C(=O)NCC2=CC(C(N)=O)=NO2 CC1=CSC(C)=C1C(=O)N2CCC[C@H1](C(=O)N3CCC[C@H1]3CC4CC4)C2 CCOCC1(C(=O)NC23CCC(NC(=O)[C@@]45CSC[C@@H1]4C5)(CC2)CC3)CC1 CO[C@H1](C)CC(=O)NC(C)(C)[C@@H1](C)NC(=O)C=1C=C2N=CC=C(C(F)(F)F)N2N=1 CCC(F)(F)C(C)(C)C(=O)N[C@@H1](C)[C@@H1]1CCN(C(=O)C2=CCC2)C1 CSC=1SN=NC=1C(=O)NCC2CC(NC(=O)C3=CN=CC4=C3CCCC4)C2 CN=C1C=C(C(=O)N2C[C@@H1]3C[C@]3(NC(=O)CC4(NC(C)=O)CC4)C2)C=C[NH1]1 COC(=O)CC[C@@H1]1CS(=O)(=O)CCN1C(=O)NC[C@H1]2CCCOC2 C#CC1(C(=O)N2CCC[C@@]3(NC(=O)C4(O)CCCCCC4)CCC[C@H1]23)CC1 C=C[C@](C)(O)CC(=O)N1CCC[C@@H1]1CN(C)C(=O)C2=NN(C)C(C3CC3)=C2C O=C(NC1=CC=CC(F)=C1F)[C@H1]2CC(F)(F)CN2CC3=CC(Cl)=CN=C3Br COCCC1(C(=O)N[C@H1](CO)CNC(=O)[C@@H1]2CCC3(CCC3)C2)CCCC1 CC1(C)[C@@H1](NC(=O)C2=CC(F)=C(O)C(F)=C2)CCN1C(=O)CC3(O)CCOCC3 CC(C)CSCC(=O)N1CC[C@@]2(CO[C@@H1](CNC(=O)CCC3CC3)C2)C1 CS(=O)(=O)NC1=CN=CC(C(=O)N[C@@H1](CO)CNC(=O)C2=CC=3C=CSC=3S2)=C1 CCC(=O)CCC(=O)N1CC[C@@H1]2CCC[C@@]21C(=O)NC3(C)CC4(CCC4)C3 C[C@H1]1CN(C(=O)C2=CC=CN=C2F)CCS1(=O)=O CC1=CC=C(C)C(C(=O)N[C@@]23CCC[C@H1]2N(C(=O)C4=C[NH1]C=C4C)CCC3)=C1C CC(C)(C)C[C@@H1]1C[C@H1]1C(=O)NC[C@H1]2CCN(C(=O)C=3C=NN(C4CCCC4)C=3)C2 COCC(COC)CC(=O)N[C@]1(CNC(=O)CCCC2CCCC2)CCOC1 CN1C=C(SCC(=O)N2C[C@@H1]3CC[C@]3(NC(=O)CC4=CC=CN4C)C2)C=N1 O=C(N[C@H1]1CCSC12CN(C(=O)[C@H1](O)CC(F)F)C2)C3=CN=CC4=C3CCCC4 CN(C)C1CCN(C(=O)[C@@H1]2C[C@@H1](F)CN2C(=O)C3=CC([N+1](=O)[O-1])=CC=C3F)CC1 CC1=CC=CC(C(F)(F)C(=O)NC[C@H1]2CCN(C(=O)CC3=CN=C[NH1]3)C[C@@H1]2C)=N1 CC1=CN=C(C(=O)N[C@@H1]2CCN(C(=O)C3=NC=C(C#N)C=C3C)C[C@@H1]2C)N=C1 COC(=O)C1=CC(=NC(=O)C2=N[NH1]C3=C2CN(C(=O)C=4C=NON=4)CC3)[NH1][NH1]1 O=C(CC1=CC=CC(O)=C1)N2C[C@H1]3C[C@H1]2CCN3C(=O)CC4CC(C(F)F)C4 CCCN(C(=O)C1=CC(Cl)=CC=N1)[C@H1](C)C(=O)NCC2=CC=NC=C2OC NC(=O)C1=NO[C@@H1](CNC(=O)C2([C@@H1]3CCCN3C(=O)[C@H1]4CC5=CC=CC=C54)CC2)C1 CC(C)C1=NO[C@H1](C(=O)N2CC[C@@H1](NC(=O)C3=CSC(CC(F)F)=N3)[C@H1](O)C2)C1 CC1=NC=NC(C)=C1C(=O)N(C)C[C@@]2(O)CCCN(C(=O)COCCCF)C2 CCC1=NC=CN1CCNC(=O)C2=C[NH1]N=C2CCNC(=O)C[C@@H1]3CC4(CC4)CO3 CC(C)[C@](C)(O)C(=O)NCCSCC(=O)NCC[C@]1(O)CCOC1 CC[C@H1](C)[C@@H1](CC(=O)N1CCC(CCNC(=O)CCCC#N)C1)NC O=C(NCCC[C@H1](O)C(=O)NCCN1C=NN=N1)C2=CC=CC=3OC=CC2=3 CC1=NN=NN1CC(=O)N(C)C[C@@H1]2CCCN2C(=O)[C@@]3(C)C[C@H1]3C O=C(CN1C=CC=CC1=O)N[C@H1]2C[C@@H1](NC(=O)C3=CC=CC=C3)C24CCC4 O=C(NC1CC([C@H1]2CCN(C(=O)CC(F)(F)F)C2)C1)C3=CN=CC=4C=CSC3=4 O=C(N[C@H1]1C[C@@H1]2CC[C@H1](C1)N2C(=O)C3=NC4=CN=CC=C4S3)C5CCCCCC5 CC1=CC=C(Br)C(C)=C1C(=O)N2CCC(O)(CC(=O)N3CC[C@@H1](CO)C3)CC2 CO[C@H1](C(=O)NC[C@@H1]1C[C@H1]2COC[C@H1]2N1C(=O)C=3N=C(O)[NH1]C(=O)N=3)C(C)C CC1=CC=CC(CCC(=O)N2CCC[C@](O)(CCNC(=O)C3=CN=N[NH1]3)C2)=C1 C=CCN(CCC(=O)NC[C@@H1](O)C1CCCCC1)C(=O)[C@H1](SC)C2CC2 CN(C1=NC=NC2=C1C=CN2C)[C@H1]3CCCN(C(=O)C4=CC=CC(=O)N4C)C3 CC[C@@H1]1CC[C@H1](C(=O)N2CC3(CCCCN3C(=O)[C@@H1]4CC[C@H1]5C[C@@H1]4C5(C)C)C2)O1 N#CC1=CC(F)=CC([C@H1](C(=O)NC2CCCC2)N3C[C@@H1]4C[C@H1]3CS4)=C1 CCN(CC)[C@@H1]1CCN(C(=O)[C@@]2(C)CCCN(C(=O)[C@@H1]3C=CC(=O)N=N3)C2)C1 C[C@@H1](C(=O)N[C@@H1]1C[C@@H1](NC=2C=CC3=NN=NN3N=2)C14CCC4)C5=CC=C(F)C=C5 CC1=CC=CC=C1C[C@@H1](NCC(F)(F)CN)C2CCCC2 CC1=CC=C(C(=O)N2CCN(C(=O)[C@H1]3C[C@H1](O)C3)C[C@H1]2C4CCC4)O1 CCCN(C)CCC(=O)N[C@H1](C(=O)N[C@H1]1CCCN(O)C1=O)C2(O)CCC2 COCN1C=CC(C(=O)N(CCNC(=O)C=2SC=C3C=2OCCO3)C4CC4)=N1 CN=[S@@]1(=O)CCC[C@@]2(CCCN2C(=O)C3=CC=CC(N4C=C(CNC)N=N4)=C3)C1 CC(C)C1=NC=C(C(=O)N2C[C@@H1](CNC(=O)C3=NC=CN3C)O[C@H1]4CCC[C@@H1]42)S1 CC1=CC(C)=C(C(=O)N[C@@H1]C2CC[C@H1](C(=O)NCCC=3C=NN(C)C=3)CC2)C=N1 CCOCCO[C@@H1](C)C(=O)N1CCC2(CC1)C[C@H1]2CNC(=O)C3=CC(C#N)=NO3 CCCC[C@@H1](O)CC(=O)NCC(CC)(CC)NC(=O)[C@@H1]1C[C@H1]1C2=CC=CC(O)=C2 CC=1N=C(Br)SC=1C(=O)N2C[C@@H1](C(=O)O)C3(CCC3)C2 C[C@H1]1CCC[C@H1]1NCC2=NC3=CC=CC(C(F)(F)F)=C3S2 C[C@@H1](CN)CNC1=NC=C(C(=O)N(C)C)S1 C=C[C@H1](O)C(=O)N1CC2(C[C@@H1](NC(=O)[C@@H1]3NC4=CC=CC=C4S(=O)(=O)N3)CO2)C1 O=C(NC1=CC=CC2=C(O)C=CC=C12)[C@H1]3CC=C[C@H1](NC(=O)C4(F)CC4)C3 COC1=CC=C([C@@H1](C)CCNC(=O)N[C@H1](CCO)C2CC2)C=C1 CC1=C(I)C=CC=C1C(=O)N2CC(N3C=C(NC(=O)C4(C)COC4)C=N3)C2 CC(C)CC1=C[NH1]C(C(=O)N[C@H1]2CCC[C@]23CCN(C(=O)CSC(C)(C)C)C3)=C1 O=C(NCC1(O)CN(C(=O)CSC2=NN=C(S)S2)C1)[C@@H1]3CC[C@H1](C=4C=C[NH1]N=4)O3 CC1=CC=NC(C(=O)N2CCCN(C(=O)C(=O)N=S(C)(C)=O)C[C@H1]2C)=C1F CO[C@@H1]1C[C@H1]1C(=O)N2C[C@H1]3CC[C@@](NC(=O)C=4C=C(Cl)C5=N[NH1]C=C5C=4)(C3)C2 C#CC[C@]1(C(=O)N2CC[C@@H1]([C@H1](C)NC(=O)C(OC)OC)C2)CCCO1 N=C1N=C(O)C(C(=O)N2C[C@H1]3CCN(C(=O)C4=CN=CC(F)=C4)CC[C@H1]3C2)=C[NH1]1 CC[C@H1](C)C1=NN=C(N2CC[C@H1](CC#N)C2)N1CC(C)(C)C C#CC[C@H1](CCOC)NC(=O)C(C)(C)[C@@H1](C)NC(=O)[C@H1]1CCSC1 CC[C@](C)(COCC1=CC=CC=C1)C(=O)NC[C@@H1](CO)NC(=O)C2(C)CCCC2 CCCC(C)(C)C(=O)N1CC[C@H1](C2(NC(=O)C=3C=NN(C(C)C)N=3)CC2)C1 COCCCC(=O)N1CCC[C@@H1]1[C@H1](C)NC(=O)C2=CC=CC=3SN=CC2=3 O=C(NOCCC(F)F)[C@H1]1CN(C(=O)C2CCC3(CC2)CC3)CC14CCC4 C[C@H1](CCNC(=O)C=1C=NSN=1)NC(=O)[C@H1]2CCC3=CC=CC=C32 CCN1C=CC(C(=O)N(C)[C@H1]2CC[C@@H1](NC(=O)C=3C=CN4C=3CCCC4)C2)=C1C CCOC1=CC=C(CN(C)C(=NC[C@@H1]2C[C@@H1](CC(N)=O)CO2)NC3CCCCC3)C=C1 CC=1C=COC=1C(=O)N[C@](C)(CNC(=O)C=2[NH1]C3=C(Cl)C=CC=C3C=2C)C(C)C C#CC1=CC=CC([C@@H1](C(=O)O)N2CCC[C@H1](C(=O)N(CC)CC)C2)=C1F C#CC1=CC=CC(C(=O)N2CCC[C@@H1]2CCCNC(=O)CC=3C=CSC=3)=C1 O=C(NCC(=O)NC[C@]1(O)CCN(C(=O)[C@@H1]2CCCO2)C1)NCC3=CC=CC=C3 CC[C@H1](C)OC1=CC=CC=C1C(=O)N[C@@H1]2COCC[C@@H1]2NC(=O)CCC3=CN=N[NH1]3 COC[C@H1](C)[C@@H1](C)C(=O)NC1=CC=CC(CNC(=O)C2=C(Cl)CC2)=C1 O=C(NC=1ON=C2C=CC=CC=12)[C@H1]3CC34CN(C(=O)COC5=CC=CC=C5F)C4 C=C(C)CN(CC)C(=O)C=1C=CN(CCNC(=O)[C@@H1]2[C@H1](CN)C23CCC3)C=1 CO[C@@](C)(CC1CCC1)C(=O)NC[C@@H1]2CCN(C(=O)C3=CN=CC(C)=C3C)C2 COC1=CC(C(=O)N[C@@H1]2CCN(C(=O)[C@H1]3CSC4=CC=CC=C43)C2)=CC(F)=C1F O=C(C[C@H1]1CCCN1C(=O)CC2C[C@H1]3C[C@@H1]3C2)NCC=4C=NSC=4 COC1=CC=C2C(=C1)[C@@H1](C(=O)N(C)[C@@H1](CNC(=O)CCCCC#N)C3CC3)CC2 CCN(CCCNC(=O)C(C)=C1CCCC1)C(=O)C2CCC(F)(F)CC2 CC(=O)N(C)CCC(=O)N1CCC[C@H1]1[C@H1](C)NC(=O)[C@@]2(CO)CC2(F)F C[C@@H1]1CN(C(=O)CN2C=NN=C2)CC[C@H1]1NC(=O)[C@@H1]3COC(C)(C)C3 CC(C)NC(=O)CCNC(=O)[C@@H1]1[C@H1]2C[C@H1]2CN1C(=O)[C@@H1](O)C3CC3 CC(C)N1N=CC(C(=O)NC2(CCNC(=O)[C@H1](C)CC3CC3)CCC2)=C1Cl CCOCCC(=O)NC[C@H1]1CCN(C(=O)[C@@H1](O)C2=CC=CC=C2)C[C@@H1]1C C[C@H1](C(=O)N1CCC[C@](F)(CNC(=O)C2=N[NH1]C3=C(F)C=CC=C23)C1)C(F)F C#CCOCCC(=O)NC[C@@H1]1CN(C(=O)CC=2C=CN(C(C)C)N=2)[C@H1]3C[C@@H1]31 COC(=O)C1=CC(I)=C(OCC(=O)NC2=CC=CC=C2N3C=CC=C3)C(OC)=C1 CC=1SC(O)=NC=1C(=O)NC[C@@H1]2C[C@@H1]2NC(=O)C=3C=C4N(C=3)CCCC4 C[C@@H1]1CC[C@@H1](CNC(=O)C2=CN=CO2)N(C(=O)C=3ON=C4C=CC=CC=34)C1 C=C(Cl)CN=C(NCC(F)(F)C1=CC=CC(C)=C1)N[C@H1](C)[C@H1]2CCCO2 O=C(NC[C@H1]1CCCCN1C(=O)[C@@H1](F)C2CCOCC2)C=3C=CC4=CN=NN4C=3 CC1=NNC(=O)[C@H1]1CC(=O)NC[C@]2(C(=O)NCC(=O)NC3CCC3)CC24CCC4 CCOC=CC(=O)N[C@@H1]1[C@@H1]2CC[C@H1]1N(C(=O)[C@H1](C)C3=CC=C(F)C(F)=C3)C2 CC[C@H1](CNC(=O)C[C@@H1]1CC2(CC2)CO1)NC(=O)C3=CN(C)C(=O)N(C)C3=O COC(=O)CC=1OC=C(C)C=1C(=O)NCC2(NC(=O)C3(CCF)CC3)CCC2 CCC[C@@H1](NC(=O)C1=CN(CC)C=N1)C(=O)N2CC[C@H1]2C(=O)NC CC[C@H1](SC)C(=O)N1CCSC[C@H1]1C(=O)N[C@H1](C)C=2C(C)=N[NH1]C=2C NC1=CC(F)=C(C(=O)NC[C@@H1]2CC[C@H1]2NC(=O)C3CC(F)C3)C=C1Cl CN1N=NC=2C=C(C(=O)NCC[C@H1]3CCCN(C4=NC=C(Cl)C(O)=N4)C3)SC=21 CC1=N[NH1]C(C)=C1CC(=O)N2[C@@H1](C(=O)NN3C=CC=N3)[C@@H1]4C[C@@H1](O)[C@H1]2C4 CCC=1ON=C(C)C=1CN2C(C3=CC=CC=C3)=CSC2=NC4=CC(O)=CC=C4Cl NC(=O)C1=CC=NC(C(=O)NC[C@@H1]2[C@@H1](C3CC3)CCN2C(=O)CC(=O)NC4CC4)=C1 CCOC(=O)CN1N=CC=C1C(=O)N2C[C@H1](O)[C@H1](NC(=O)C=CCOC)C2 CC1=CC(F)=CC(CC(=O)NCC2(F)CN(C(=O)C(C)(C)C3CCOCC3)C2)=C1 CC[C@H1](C)CC(=O)N[C@@H1](CC=1C=COC=1)C(=O)N2CCN3CCCC[C@@H1]3C2 O=S(=O)(N[C@@H1]1CCC=CCCC1)C2=CC=C3N=C(N4C[C@H1]5C[C@H1]5C4)SC3=C2 O=C(N[C@@H1]1C[C@H1]2C[C@H1]1CN2C(=O)C3=CC(Cl)=CS3)C4=CC(=O)C=C[NH1]4 C[C@H1](NC(=O)C[C@H1]1CCC[C@H1]1C)C2=CN(CC3=NN=C4C=CC(Cl)=CN34)N=N2 C[C@H1]1COC2=CC=CC=C2N1CCNC(=O)NCCC3=NC(C4CC4)=NO3 C[C@@H1]1C[C@@H1]2CCC[C@@H1]2N1CC(=O)N[C@@H1]3CCN(C4=CC=CC(F)=C4C#N)C3 CCC(C)(C)[C@@H1](O)C(=O)N1C[C@@H1]2C[C@H1]1[C@H1](N(C)C(=O)CCCSC)C2 CCC[C@]1(NC(=O)[C@]2(C)CN(C(=O)CC3(O)CCC3)C[C@H1]2C)CCOC1 COC[C@H1]1CCN(C(=O)[C@@H1](CC2=CC=C(Cl)C=C2Cl)NC(=O)C3=C[NH1]N=C3C)C1 COC1=CC(N2N=C([C@H1]3CCCO3)N=C2C[C@H1]4NC(=O)NC4=O)=CC=C1Cl C=CCC(C)(C)C(=O)NCCN(C(=O)[C@@H1]1SCCC=2SC=CC=21)C3CCCCC3 CCN1CC[C@@H1]1C(=O)NC2(CNC(=O)CC3(N(C)C)COC3)CCCCCC2 COC[C@@H1](C)C(=O)N1CC[C@H1]1CNC(=O)CC2=CC=CC(NC(C)=O)=C2 CCOCCCC(=O)N1CC[C@H1](C)N(C(=O)C=C(C)C(C)(C)C)CC1 CCS[C@@H1](C)C(=O)N1CCN(C(=O)C2=CN=C(O)C(F)=C2)C[C@H1]1CC3CC3 O=C(CC12CCC(CC1)C2)N3CCO[C@@H1](CC(=O)N4CC(O)(C=5N=N[NH1]N=5)C4)C3 CC[C@@H1](C=1SC=NC=1C(=O)O)NC(=O)CCN2C=C(C(C)(C)F)N=N2 CC1=CC=C(C(=O)NC[C@]23CCC[C@H1]2CCN3C(=O)CC4=CC=CO4)S1 CCCCN1N=NN=C1[C@H1](NC2=CC=C(OC)C(C(C)C)=C2)[C@@H1]3CC=CCC3 CCOC1=NC=C(C(=O)N2CC[C@@H1](O)[C@H1]2C(=O)N3CCO[C@@H1](C(C)C)C3)C=N1 C[C@H1]1CCC=2[NH1]C(=NC[C@H1]3COC[C@H1]3O)[NH1]C(=NCCN(C)CCO)C=2C1 CO[C@@]1(CO)CCN(C(=O)[C@@H1](NC(=O)CN=[N+1]=[N-1])C2=CC=CC=C2)C1 CCC1CC(C(=O)N[C@H1](C)[C@@H1]2C[C@H1]2C(=O)NCC3=CC(C)=C(C)S3)C1 O=C(CC(F)(F)C(F)(F)F)NCCCCNC(=O)C=1C=NN(C2CCCCC2)C=1 O=C(C[C@H1]1CCC(=O)N1)NCC(=O)NCC(=O)NCC2(O)CC=CC2 COC(=O)C1(CNC(=O)[C@@H1](CC=C(C)C)C2=CC=C(C(=O)OC(C)(C)C)O2)CC1 COC(=O)N[C@@H1](C)C(=O)N1C[C@H1]2C[C@H1](C)N(C(=O)C=3C=CN(C)N=3)[C@H1]2C1 CC(C)N(C)CC(=O)N[C@H1]1CC[C@H1]1CNC(=O)CN2N=CC3=CC=CN=C32 CC[C@H1](F)C(=O)N(C)C[C@H1](C)CNC(=O)C1(C2(O)CCOCC2)CC1 CC[C@@H1](CNC(=O)CN1C=CC(O)=NC1=O)NC(=O)C=2C(OC)=NOC=2C3CC3 CCC1=CC(C(=O)N(C)C[C@H1]2COCCN2C(=O)CC[C@H1]3CC3(Cl)Cl)=CC(O)=N1 CN(C[C@H1](O)CNC(=O)CP(C)(C)=O)C(=O)C1=C(Br)C=NC=C1[N+1](=O)[O-1] CCOCC(=O)N1CCN(CC(=O)NCC2CC=CC2)CC1 CC1=C(N)C=CC=C1C(=O)N2CC[C@@](CF)(NC(=O)[C@H1]3CC3(Cl)Cl)C2 CCCC=1C=C(C(=O)NCC[C@@H1](C)N(C)C(=O)C=C2CCC(C)CC2)N(C)N=1 CC1=CC=C(Cl)C(CN2CCO[C@H1](C(=O)N3CCOC4(CC4)C3)C2)=C1F C#CCC(C)(C)C(=O)N1CC([C@@H1]2CCCN(C(=O)[C@H1](C)O[C@@H1]3CCOC3)C2)C1 CCN1C=CC(C(=O)N[C@@H1]2C3C[C@H1]4[C@@H1](C3)C42C(=O)N5CCC[C@@H1]5C)=N1 CC(Cl)=CC(=O)NCCCN(C(=O)CCCC1=NN=CN1C)C(C)C O=C(N[C@]1(CO)C[C@H1]2CCC[C@H1]21)C3=C(F)CN(C(=O)CCC4=CC=CN=C4)CC3 N=C1[NH1]N(CC(=O)N2CC[C@@H1](C3=CC=C(F)C(F)=C3)C24CC4)C=C1Br C[C@@H1]1CCN(C(=O)C#CC2CC2)C[C@@H1]1CNC(=O)C=3C=CN(C(F)F)N=3 COC[C@@H1](C)CC(=O)N1C[C@@H1]2C[C@]2(NC(=O)CC3=CC=C(Br)C=N3)C1 CC[C@@H1](C(=O)OC)C(=O)N1CCC[C@H1]([C@H1](C)NC(=O)C2=CC=C(C)C(F)=C2F)C1 CC1=CC(C(=O)N2C[C@H1]3CC[C@H1]2[C@@H1](CNC(=O)CN4C=NN=N4)C3)=NC(O)=N1 CC1=C(C2=CSC(C(=O)N[C@@H1](CCO)C3=CC=C(F)C=C3)=N2)C=CC4=N[NH1]C=C14 CC(C)N1C=C(C(=O)N2CCCCC[C@H1](NC(=O)COCCN(C)C)C2)N=N1 CC(C)(C)OC1=CC=CC=C1C(=O)N2CC3(CC[C@@H1]3CNC(=O)[C@H1]4CCSC4)C2 CC1(C)CO[C@@H1](CC(=O)N2C[C@@H1](NC(=O)C=CC3=CC=CC=C3)CC(F)(F)C2)C1 C=C[C@@H1](C)NC(=O)C1(CCOC)CCN(C(=O)CC2=CSC3=NC(C)=CN23)CC1 C=C=C[C@H1](C)C(=O)N1C[C@H1]2C[C@@H1](C(=O)N[C@@H1]3CC[C@H1](O)[C@H1](O)C3)C[C@H1]2C1 O=C(N[C@@H1](CC=1C=COC=1)C(=O)N=C2C=CN(CCF)[NH1]2)[C@H1](F)C3CCCC3 C[C@H1]1C(C(=O)NCC[C@@H1]2CN(C(=O)C3=CN(C4CCCC4)N=N3)CCCO2)[C@@H1]1C CC1(NC(=O)C=2C=CN3N=NC=C3C=2)CCC(NC(=O)C4CC4)CC1 CC1=CN=NC(O)=C1C(=O)N[C@H1](C)CNC(=O)C2=CC=C([N+1](=O)[O-1])C=C2O C[C@@H1]1CN(C(=O)C2=CC=NN2C3=CC=CN=C3)C[C@H1]1CNC(=O)C=4C=NN(C)C=4 CSC1CC(C(=O)NC[C@]2(F)C[C@H1](CNC(=O)COC3=CC=CN=C3)C2)C1 O=C(CSC1=CC=CC(C(F)(F)F)=C1)NCC2(CCNC(=O)C3(O)CC3)CC2 C[C@H1](C(=O)NC1CCS(=O)CC1)[C@H1]2CCCN(C(=O)C3(F)CCCCCC3)C2 C=C(C)CCCC(=O)NCC1(F)CN(C(=O)[C@@H1]2CC[C@@H1](C3=CC=CC=C3)C2)C1 CC1=CC=CC(F)=C1C(=O)N2C[C@H1](F)[C@H1](NC(=O)C3(C4=CC=C(O)C=C4)CC3)C2 CC=1N=NN(C)C=1C(=O)N[C@H1](CNC(=O)CNC(N)=O)C2=CC=CC=C2 C#CC1=C[NH1]N=C1C(=O)N2CCC[C@H1]2[C@@H1]3CCN(C(=O)CC=4SC(S)=NC=4C)C3 CCC1CC(C(=O)N(CC)[C@H1]2CCCN(C(=O)C3(CC4CCC4)CC3)C2)C1 COC1=C(C(=O)N2CC=C(C(=O)N3C[C@H1]4CC[C@@H1](C3)C4C#N)C2)C=CC(Cl)=C1Cl CCN1N=CC(Cl)=C1C(=O)N(C)C2CC(NC(=O)CCNS(C)(=O)=O)C2 CC1=CC=CC(F)=C1C(=O)N[C@H1]2CN(C(=O)C3=CC(O)=NC(C4CC4)=N3)C[C@@H1]2C CCC1=NC=CC=C1C(=O)N[C@@]23CCN(C(=O)CCCCCNC(N)=O)C[C@H1]2C3 O=C(NC1(CO)CN(C(=O)C2=CC3=CC=C(O)N=C3S2)C1)C4=CC=C(Cl)S4 CC=1C=C(C)N(CCC(=O)NCC2(NC(=O)C=3[NH1]C=CC=3C)CCC2)N=1 CC1=NC(C(F)(F)F)=C(C(=O)NC[C@@H1](O)CNC(=O)C[C@H1](C)O)S1 CC[C@@H1](C)C(=O)NCC(=O)N1CCOC[C@H1]1CNC(=O)C2=CC=C3SC=CC3=C2 CC(C1)CC[C@H1](C(=O)N2C[C@@H1](NC(=O)C34[C@H1]5CC(C[C@H1]53)C4(F)F)[C@H1](C(F)F)C2)OC1 C#CCN1C=NN=C1C(=O)N[C@@H1](C)[C@H1]2CCN(C(=O)C3=CC=4C=C[NH1]C=4C=N3)C2 CC(C)(C)C1=NC=C(C(=O)N2CCN(C(=O)C=C(Cl)Cl)C[C@@](C)(F)C2)[NH1]1 C=CC(C)(C)NC(=O)[C@H1]1CN(C(=O)C2CC3=CC=CC=C3C2)CCC1(C)C C[C@H1](NC=O)C(=O)NC1(CN(C)C(=O)[C@H1](F)C[C@H1]2CCOC2)CC1 C[C@H1](CC1=CN=CO1)C(=O)N[C@]2(CNC(=O)CN3C[C@H1]4C[C@@H1]4C3)CCOC2 CCC1=CC(NC(=O)CNC(=O)CNC(=O)[C@H1]2C[C@H1]3C=C[C@@H1]2CC3)=CC=C1C CC(C)(C)OC(=O)NC1=CNC(=O)N=C1C N#CC1=CC=CC=C1N(C(=O)C=2C=C[NH1]C=2)[C@H1]3CCC34CCCCC4 CC(C)(C)[C@@H1](CNC(=O)CCC1=CC=C(F)C(F)=C1)NC(=O)C2=CCCCC2 C=CCC(C)(C)C(=O)NC[C@@H1]1C[C@H1](C(C)C)CCN1C(=O)CCCNC(N)=O C[C@@H1](C(=O)N1CC(CCCCNC(=O)CCC2CCCC2)C1)C3=CN=CC=N3 CN(C)CCSCC(=O)NC1(CO)CN(C(=O)COC2=CC=CC=C2[N+1](=O)[O-1])C1 CO[C@H1]1CC[C@@H1](C(=O)NC[C@](C)(NC(=O)CN2N=C(C)N=C2C)C3CC3)CC1 C=CCN(CCC(=O)NCC1=NC=NN1CC)C(=O)[C@H1]2CCC(=O)N2 C#CC=1C=NN(CC(=O)N[C@H1](C)CCCNC(=O)C=2C=CSC=2C#N)C=1 C=C=CCCC(=O)N1C[C@@H1](NC(=O)C2(C3=CC=CC(OC)=N3)CC2)[C@H1](C)C1 CN(CCNC(=O)C(C)(C)CC1=CC=C(Cl)C=C1)C(=O)[C@]23COC[C@H1]2C3 CC1(CNC(=O)C[C@]2(C)CCOC2)CCC(NC(=O)[C@@H1]3[C@H1]4CC(=O)C[C@H1]43)CC1 CC1=CC(OCC(=O)N[C@H1]2CO[C@@H1][C@@H1](NC(=O)C(C)(F)F)CO[C@H1]2)=NO1 CC[C@H1](C#N)C(=O)N1CC[C@@H1]2[C@@H1](NC(=O)C=3C=NN(CC(F)F)C=3)[C@@H1]21 CC1(C)C=C(C(=O)NC[C@]2(C)CC(F)(F)CN2C(=O)C3=CC=C(F)O3)C1 COCC=CC(=O)N[C@]12CC[C@H1]1CN(C(=O)C=3[NH1]C=C4C=3CCCC4(C)C)C2 O=C(C=1N=C2C=CC(Br)=CN2C=1F)N3CCC[C@@H1](C(=O)N4CC(F)C4)C3 CCCCN1N=C(C)C(CNC[C@H1]2CCC[C@H1](O)C2)=C1C CC[C@H1](C)C=1N=C(C2=CC=C(CN3CC[C@H1](O)C3)C=C2)N(C4=NC(C)=NN4C)N=1 CN1N=NC(/C=C/C(=O)N[C@@H1]2CCC[C@@H1]2NC(=O)C3=COC4=CC=CC=C4O3)=N1 CC(=O)N1C[C@@H1]2C[C@H1]1CN2C(=O)C3=CN=C(CNC(=O)[C@H1](C)[C@H1]4CCOC4)N=C3 C[C@H1]1CCC=C1C(=O)N(C)[C@H1](CNC(=O)C2=NN3C=CC=NC3=C2Br)C4CC4 CC1=CC(=O)C(C(=O)N2CC3(CCN(C(=O)[C@@H1]4CCC5(CC5)C4)CC3)C2)=CN1C O=C(NC[C@@H1]1CCC2(CN([C@@H1]3CCN(C4CC4)C3=O)C2)O1)C5=C[NH1]C=CC5=O COCCSCC(=O)NCC[C@@]12CC[C@H1]1CN(C(=O)CC3(N4C=NC=N4)CC3)C2 CCOC1=NC=CC=C1C(=O)N2CCC3(CC2)CCN(C(=O)C4(C)CCCS4)C3 CC(=O)NC1(CC(=O)N(C)CCOCCC(=O)NC=2C=NN(CC3CC3)C=2)CC1 C#CCCCCNC(=O)[C@@H1]1[C@H1](C)CCN1C(=O)C[C@H1](C=C)CC O=C(NC[C@@]12CC[C@@H1](C1)N(C(=O)[C@@H1]3CCCN3C4CC4)C2)C5=CC=CC(F)=C5 CC[C@H1](CC(=O)N[C@H1]1CC[C@H1](NC(=O)C2CN(C(C)=O)C2)CC1)SC CCCCC[C@@H1](C)CC(=O)N(C)C[C@@H1](CC)NC(=O)C1=CC(O)=CC=C1O C#CC[C@@H1](C(=O)N1CC[C@@H1](C)[C@@H1](N(C)C(=O)C2CSC2)CC1)C3CC3 CC(=O)C(=O)NCCC1=CN=C(NC(=O)C2=CC(C3=CC=NN3C)=C(Cl)S2)S1 C[C@H1](O)CCC1=CN([C@H1]2COC[C@H1]2NC(=O)C3(C4=CC=C(C(N)=O)C=C4)CC3)N=N1 COC[C@]1(C(=O)N2CC3(CCC(O)CC3)C2)C=CCN1C(=O)CC[C@@H1](C)SC O=C(N[C@@H1]1C[C@@H1]2CC[C@H1](C1)N2CC3=CC([N+1](=O)[O-1])=C(Br)C=C3F)C4=COC=N4 O=C(CN1C(=O)C2=CC=CN=C2C1=O)NC3=NC=CN3CC4=CC=CC(Cl)=C4 C[C@H1]1CN(C(=O)C2=CC3=CN=CC=C3C=C2F)CC[C@@H1]1NC(=O)OC(C)(C)C C=CCCOCCCCC(=O)N(C)[C@H1]1CC[C@@H1](NC(=O)CN2C=NN=N2)CC1 COC1=CC=CC=2C(C(=O)N3C[C@H1](C)[C@H1](NC(=O)C4=CC(C)=NN4C)C3)=N[NH1]C1=2 O=C(NC[C@@H1]1CN(C(=O)C2=CC=CC3=CC=CN=C23)CCO1)[C@@H1]4C[C@@H1]5C[C@H1]4CO5 CN1CC(C(=O)N2CC[C@@H1]3C[C@@]32C(=O)N4CC[C@]5(CNC(=O)O5)C4)C1 COCC1=CSC(CN2CCC3=CC(O)=CC=C3[C@@H1]2C)=C1 CCCC(=O)NCC(=O)NC[C@]1(F)CCCN(C(=O)[C@H1](OC)C2CCCCC2)C1 CC(C)N(CCCCCNC(=O)C1=CC=CC(O)=C1F)C(=O)COCC=2N=C[NH1]N=2 CC1=CSC(C(=O)N[C@H1]2C[C@@H1](CCC(=O)NCC3=CC=NC=C3C)C2)=C1 CN1CC(O)(CNC(=O)CCCCN(C)C(=O)COC[C@H1]2CCOC2)C1 CC1CCC(O)(C(=O)N2CC[C@H1](CO)[C@H1](NC(=O)[C@@H1](C)N3CCC3)CC2)CC1 CCC1=NOC=C1C(=O)N(C)[C@H1]2CN(C(=O)C3=C[NH1]N=C3C4=CC=CO4)C[C@@H1]2F NC1=C(C(=O)NCC2CC(OC(C)(C)C)C2)C=NN1C3CCCC3 CN(C)CC[C@H1](O)C(=O)N1C[C@@H1](F)C[C@H1]1CN(C)C(=O)C=2OC=C3C=2CCCC3 CC=1N=C(C)N(CC2=CC=C(C3=CC=C(C(=O)N[C@H1](C)CO)C=C3)C=C2)N=1 CC1=CC(C(=O)N(C)CCN(C)C2=NN=C(C3CC3)O2)=CC=N1 CC1=CC=C(C)C(C(=O)N2C[C@H1]3[C@H1](NCC4=N[NH1]C5=CC=C(Br)C=C45)[C@H1]3C2)=C1O COC/C(C)=C/C(=O)N[C@@H1]1COC[C@H1]1CNC(=O)[C@@H1](O)C2=CC=C(F)C(Cl)=C2F CN1CCCC[C@@H1]1C(=O)NCC=2N=COC=2CCNC(=O)[C@H1]3CC(=O)OC3(C)C O=C(N[C@H1]1C[C@H1](O)CN(C(=O)C2=CC(Br)=CC=N2)C1)[C@@H1]3CC4=NC=CN4C3 CCN1N=NC=C1CNC(=NCCC2=CC=CC=C2F)NCC3=CC=CO3 CC1=CC(C)=C(S(=O)(=O)N2CCC3=NN=C(Br)N3CC2C)C(C)=C1 CO[C@@]1(CNC(=O)C[C@@H1]2NC(=O)NC2=O)CCN(C(=O)C3(C)CC(C)(C)C3)C1 CCOC(=O)[C@@H1](C(=O)N[C@@H1]1CCN(C(=O)C2=NOCC2)CC[C@H1]1CO)C(C)C CC(CC1=CCCCC1)NC(=O)N[C@H1]2CCS(=O)(=O)C3=CC=CC=C32 C[C@H1](NC(=O)C[C@@H1]1CCN(C(=O)C2=CC(F)=CC(F)=C2F)C1)[C@@H1]3CCOC3 CCC(=O)N1CCC[C@@H1]1C(C)(C)CNC(=O)[C@@H1](CC)N2CCO[C@H1](CC)C2 C=CCC1(C(=O)NC2CC(CNC(=O)C3=CC4=C(O)C=CC(F)=C4[NH1]3)C2)COC1 CN(C)C(=O)C#CC(=O)NCC1(O)CN(C(=O)C2=C(Cl)C(Cl)=CC(Cl)=C2Cl)C1 O=C1CC[C@H1]2[C@H1](O1)C[C@H1]2C(=O)N3CC=CC[C@H1]3C(=O)NCCC=4OC=NC=4CO C[C@@H1](C(=O)N[C@@H1]1CN(C(=O)C2CC3(C2)CC(F)(F)C3)C[C@@H1]1F)C4=CC=CS4 CC(C)=C(C)C(=O)NC[C@H1](O)CN(C)C(=O)[C@@H1]1CCC12CCC2 CCOCC1(C(=O)N[C@H1]2C[C@@H1](C)CN(C(=O)C(C)(C)CS(N)(=O)=O)C2)CCC1 CC1=CSC([C@H1](C)N[C@](C)(CCCC(C)C)C2=NN=NN2C)=N1 COC(=O)[C@H1](NC(=O)C1(C)CC(NC(=O)[C@H1]2CCC=CCCC2)C1)C3CCC3 C#CC1=C[NH1]N=C1C(=O)NCC(=C)CCNC(=O)C(CCC)CCC CC(=O)N1CC[C@](C)(C(=O)N[C@H1](C)CNC(=O)C2=CSC(Cl)=C2Cl)C1 CCCC[C@H1](CNC(=O)C1=CN=C(N(C)C)O1)NC(=O)CC[C@@H1]2CCCO2 CCN(C(=O)C[C@@H1]1CCOC(C)(C)C1)[C@H1]2CCN(C(=O)CCN=C3[NH1]C=CS3)C2 CCN(C[C@H1](C)NC(=O)[C@H1]1CC12CCCCC2)C(=O)CCCNC(N)=O O=C(CCN1C=C([C@H1]2[C@@H1]3COC[C@@H1]32)N=N1)N4CCCO[C@H1](C5=CC=C(Br)C=C5)C4 C=C1CC(C(=O)N2[C@H1]3CC[C@H1]2CC(C[C@@H1](C)NC(=O)C[C@]4(C)C[C@@]4(F)Cl)C3)C1 CO[C@@H1]1CN(C)[C@](C)(C(=O)N[C@H1]2CN(C(=O)C3=CC=C(C(F)F)O3)C[C@H1]2CO)C1 CC1=CSC([C@@H1]2CCCN2C(=O)[C@@H1]3CC34CCN(CC5=COC=N5)CC4)=N1 CC(C)[C@]1(C)C[C@H1]1C(=O)NCC=C2CCN(C(=O)CO[C@@H1]3CCCOC3)CC2 CCOC1=CC=C([C@@H1](NC(=O)[C@@]2(C)C=CCC2)C3CCCCC3)C=C1 CC=1N=C(NC(=O)CCC2=CC=CC(Br)=C2)SC=1C(=O)NC3CCN(C)CC3 CCCC[C@H1](C)CCC(=O)N[C@H1](C)[C@@H1](CO)NC(=O)C1=C(C)N=C(C)N=C1C O=C(N[C@@H1]1CN(C(=O)C(F)=C2CCCC2)[C@H1]3CCC[C@@H1]13)C4=C[NH1]N=C4C5CC5 CC(C)CC(=O)N1C[C@@]2(C(=O)N[C@@H1](C)C3=C[NH1]C=CC3=O)C[C@H1]1CO2 CSCCN(C)C(=O)[C@H1]1CNC(=O)CN1C(=O)[C@@H1]2CC2(Cl)Cl CCC[C@H1](CCNC(=O)C12CCC(CC1)N(C(=O)C3(C)CC(F)C3)C2)C4CC4 CC1=CC=C2C(=C1)CC[C@H1](C(=O)N[C@H1](C)C3=CC=C(C)O3)O2 CC1=CC(C(=O)N2[C@H1]3CC[C@@H1]2C[C@H1](NC(=O)CCC=4N=C[NH1]N=4)[C@H1]3F)=CN=C1C CC[C@]1(C)C=C(C(=O)NCCCN(C)CCCNC(=O)C[C@H1](C)C(C)(C)C)C1 O=C(COC(=O)[C@@H1]1C[C@H1]2C=C[C@@H1]1C23CC3)NC4=CC=CC(OCCCC=5N=N[NH1]N=5)=C4 C=CCCO[C@H1](C)C(=O)N1C[C@H1](NC(=O)C=2N=N[NH1]C=2Cl)CC3=CC=CC=C31 COC1=CC=C(N2CCN(CCCN=C3[NH1]C=NC4=C(Br)C=CC=C34)CC2)C=C1 C/C=C/C[C@@H1](NC(=O)C#CC(C)(C)C)C(=O)N[C@@H1]1CCC[C@H1]1CCO CCN(CC(F)(F)F)C(=O)[C@H1]1CN(C2=NC=C(C#N)C(OC)=N2)CC[C@@H1]1O CC1=CSC(CCC(=O)N[C@H1]2CCC[C@H1](N(C)C(=O)C(=O)C(C)(C)C)C2)=N1 CSCC[C@@H1](NS(=O)(=O)C1=CC=CC=C1)C(=O)N2CCN(C)C(C)(C)CC2 CC(C)S(=O)(=O)C1=CC=C(CN=C2N=C(N3CC[C@H1](C)C3)C4=C([NH1]2)CCS4)C=C1 CC1=CN=C(C(=O)NC2(CN(C)C(=O)[C@H1]3CCCC(C)(C)O3)CC2)C(F)=C1 COCC1=CSC(C(=O)N2CCN(C(=O)C=3SC=CC=3CO)[C@@H1](C4CC4)C2)=C1 CC(=O)C1=NC=C(C(=O)NC[C@@]2(NC(=O)CC(C)(C)C)CCOC2)S1 C=CC1(C(=O)N2CC[C@H1](NC(=O)C3=CC=C(O[C@H1](C)CC)C=C3)C(C)(C)C2)CC1 CCN1C=CC(C(=O)N[C@@H1]2COC[C@H1]2CNC(=O)[C@@H1](C)N3CCSCC3)=CC1=O CCC(C)(C)NC(=O)[C@H1](C1=CN2C=C(F)C=CC2=N1)N(C)[C@@H1]3CCN(C(C)C)C3 COC1=CC(F)=C(C)C=C1[C@H1](C(=O)NC(C)C)N2CCCC[C@H1]2C3=CC=C(C)O3 CSC=CC(=O)N[C@H1]1CN(C(=O)[C@H1]2C=CCCN2C(=O)OC(C)(C)C)CC13CC3 C=CCC1(C(=O)NCC[C@@H1](C)N(C)C(=O)C=C2CCC2)CN(C(=O)OC(C)(C)C)C1 COC[C@H1]1CN(C(=O)C2=CC(C3CCCC3)=NO2)CCN1C(=O)[C@H1](C)OC(C)=O COC(=O)CC(=O)N[C@@H1](C(=O)N[C@@H1](C)C1=CC=C(C)S1)C2=C(C)C=CC=C2Br O=C(NC[C@H1]1CN(C(=O)CCC=2C=C[NH1]N=2)CCCO1)C3CCSCC3 CCCCCC1=CC(C(=O)N[C@H1]2C[C@](F)(CNC3=NC=C(C#N)C=C3F)C2)=N[NH1]1 CCC=1C=C[NH1]C=1C(=O)N[C@H1]2CCC[C@@H1](N(C)C(=O)CCCC#N)C2 CCN1CCOC[C@H1]1CC(=O)N(C)[C@@H1]2CCN(C(=O)C(F)(F)C=3C=NN(C)C=3)C2 CCOC(=O)[C@H1](C(=O)N1CC2(CN(C(=O)C=3C=NN(CC)C=3C)C2)C1)C(C)(C)C CSC1=CC=C(OCC(=O)N[C@]2(C)CCN(C(=O)C3CC(C)(O)C3)C2)C=C1 COC[C@H1](C)C(=O)NCCCN(C)C(=O)C1=NC(Cl)=CC=C1N O=C(N[C@H1]1CC[C@@H1](CNC(=O)C2=CC=C([N+1](=O)[O-1])[NH1]2)C1)C3=CC(O)=C(O)C(O)=C3 CC(C)N1C=C(CNC(=O)CNC(=O)C2=NN=C(O)N=C2O)N=N1 C[C@H1]1CCN(C(=O)C(=O)N[C@H1](C)CNC(=O)CN2N=C3C=CC=CN3C2=O)C1 O=C(CC1C[C@H1]2C[C@@H1]2C1)NCC3=NC=C(C(=O)NC4=CC=CN=C4)C=N3 C=CC[C@@H1](CNC(=O)[C@@H1](NC=O)C(C)C)NC(=O)C1=NN(C)C2=C1CCC2 CCCCS(=O)(=O)NCC(=O)N1CC2(CCN(C(=O)C3(CCF)CC3)C2)C1 CC(C)[C@@H1]1C[C@H1]1C(=O)N2CC(N3CCN(C(=O)CN(C)C)CC3)C2 C[C@]1(CNC(=O)N2C[C@@H1](N)C3(CC3)C2)OCCC4=CC=CC=C41 CC(C)C[C@H1](CNC(=O)C1(C2CC2)CCOCC1)NC(=O)[C@H1](C)CC(F)F CO[C@@]1(CO)CCN(C(=O)[C@@H1](O)CCCNC(=O)C=2C=C[NH1]C3=NC=CC=23)C1 CCCN1C=C(C(=O)N[C@@H1](CNC(=O)C(F)(F)[C@H1](O)CC)C2CCCCC2)N=N1 CS[C@H1](C(=O)N1CC(CCNC(=O)C2=CC=C(C3CC3)O2)C1)C4=CC=CS4 CC1=CC(CC(=O)N(C)C2CC(C(=O)N3C[C@H1]4CSC[C@@]4(C)C3)C2)=NO1 CC=1N=C[NH1]C=1CC(=O)NCC=2OC=NC=2CN3C=C(C(C)(C)CC4CCC4)N=N3 COC1=CC(F)=C(Br)C=C1C(=O)N2CCC(NC(=O)[C@@H1]3CC3(F)F)CC2 C#CCN(CCC(=O)N(CC=C)OC)C(=O)C1=NOC=C1Cl CSC1=CC=C(C(=O)N[C@@H1]2C[C@@H1]2CNC(=O)C3=CC=NC=4[NH1]C(C)=NC3=4)C=C1 CCOCCC(=O)NC[C@]1(CNC(=O)C2=N[NH1]C3=C2CCCC3)CC1(F)F CC1=CC(C(=O)N[C@H1]2C[C@@H1](NC(=O)CN3C=C(Cl)C=N3)C2)=C4C=CC=CC4=N1 CC=1N=C(O)[NH1]C=1C(=O)N2CC([C@@H1](C)N=C3[NH1]C(Cl)=NC4=CC=CC=C34)C2 CC1=CC(=NC(=O)[C@H1]2CC(C)(C)CN2C(=O)[C@@H1](C)N3CCOCC3)[NH1]N1C O=C(N[C@H1]1C[C@@H1](NC(=O)[C@@H1]2SCCC=3SC=CC=32)C1)[C@H1]4CCCC(F)(F)CC4 C=C[C@H1](O)C(=O)N[C@@H1]1CN(C(=O)C2=CC=C3C=C(OC)C(F)=CC3=N2)C[C@H1]1OC C[C@@H1]1CN(C(=O)C2CCC(CC#N)CC2)C[C@H1]1CNC(=O)C[C@@H1]3C=NN(C)C3=O CC(C)C(=O)NC[C@]1(O)C[C@@H1]2CC[C@H1](C1)N2C(=O)[C@H1]3COC(=O)O3 C#C[C@@H1](C)C1CCN(C(=O)[C@H1]2CN(C(=O)[C@@H1]3C[C@H1]3C#N)CC(C)(C)C2)CC1 CCOC1=NC=C(C(=O)N2CCC[C@H1]3CN(C(=O)C4=CCC4)CC[C@@H1]3C2)S1 CC1=CC(C(C)(C)C)=CC=C1O[C@@H1](C)C(=O)NC23CC(COC(C)(C)C)(C2)[C@@H1]3O C=CC[C@@H1]1CCCCN1C(=O)C=2C=C(C)N(C3=CC=C(OC)C=C3)N=2 CCN(C(=O)[C@H1](O)CCCNC(=O)[C@H1](O)C(C)(C)CC)[C@H1](C)C(=O)NC C[C@H1](CCNC(=O)C1=CC=NN=C1O)NC(=O)[C@@H1]2CCC(=O)N2C C[C@]1(C(=O)N[C@@H1]2C[C@H1](C(=O)NCCN3N=CN=N3)C[C@H1]2CO)CCC[C@@H1]1O COC1=CC=CC=C1C(=O)N2CCC=C(C(=O)N3C[C@@H1](OC)C[C@@H1](C)C3)C2 C=CC1(C(=O)NC[C@]23C[C@H1]2CN(C(=O)C[C@@H1](O)C4=CC=CC=C4)C3)CCCCC1 O=C(NC[C@H1]1CCN(C(=O)CN2N=C(O)C=CC2=O)C1)C3=CC(Cl)=CN=N3 O=S1(=O)CCC[C@H1](NC(=NCCCOC(F)(F)F)N2C[C@H1](F)[C@H1](F)C2)C1 COC1=CC=CC=C1C[C@H1](C)CC(=O)N2C[C@H1]3[C@@H1](N=C4[NH1]C=CN=C4F)C[C@H1]3C2 CN1C=NN=C1CN2CCN(N3CC[C@@H1](CN4CCOCC4)C3)CC2 C[C@H1]1C[C@@H1](C(=O)N[C@@H1]2CC[C@@H1](C)N(C(=O)CS(N)(=O)=O)C2)C[C@@H1](C)O1 CCNC(=O)CN=C1N=C2SC=CC2=C(NCCN(C(C)C)C3CC3)[NH1]1 CC(C)NC(=O)[C@@H1](C=1C=CON=1)N2CCC3=NC(C4CC4)=NC=C3C2 CC(=O)N(C)CC(=O)N1C[C@@H1](CNC(=O)C=CC2CCCC2)CC13CCC3 CNC1=CN=C(Cl)C=C1C(=O)N2CCCC3(CC(NC(=O)C4=CC=C(Cl)O4)C3)C2 O=C(CC=1C=CON=1)NC/C=C/CNC(=O)C2=CC3=C(S2)CCS(=O)(=O)C3 CCC1=CC=C(C(=O)N(CCN(C)C(=O)[C@H1](CO)N(C)C)C(C)C)C=C1Cl O=C([C@@H1]1CCCCCN1C(=O)[C@]23CCC[C@H1]2C3(F)F)N4CCCC[C@H1]4CCCO C=CCC[C@@H1](CO)NC(=O)CC1(C=C)CN(C(=O)C2=CC=CC=3[NH1]C=CC2=3)C1 COC(=O)[C@@H1]1CCC2(CCCC2)N1C(=O)C3CC(C(C)(C)C)C3 CC1=CC(N)=C(C)N=C1C(=O)N(C)CCOCCNC(=O)C=2SC=CC=2C3CC3 C#CC[C@@]1(C(=O)N(C)CCOCCC(=O)N2CCO[C@H1](C(C)C)C2)CCCO1 C[C@H1](C(=O)N1CC[C@](O)(CNC(=O)[C@H1]2C[C@H1]3CC(=O)[C@@H1]2C3)C1)[C@H1]4CCCO4 COC(=O)[C@H1](C)C(=O)NCC[C@@H1](C)N(C)C(=O)C1=CC=C2C(=C1)CCCO2 CCC=C(F)C(=O)N[C@H1]1[C@H1]2C[C@@H1]1N(C(=O)[C@]3(O)CC3(C)C)C2 C=CCNC(=O)CNC(=O)C12CC(C)(CN1C(=O)C3=CC(C)=C(C)C=N3)C2 CC=1ON=CC=1C(=O)NC2=CC=C(NC(=O)C(=O)N3CCC(F)(CN)CC3)C=C2 N[C@@H1](CC=1C=CSC=1)C(=O)NCCC23CC(N)(C2)C3 C=C=C[C@H1](C)C(=O)NC1(C(=O)N=C2C=CN(C)[NH1]2)CSC1 CSC[C@H1](O)C(=O)NCCC1(NC(=O)[C@@H1](C)CC=2C=NN(C)C=2)CC1 CC(C)(C)N1CCC[C@H1](N2CCC(CC3=CC=CC=C3Cl)CC2)C1 COCCOC1=CN=CC(C(=O)N[C@]2(CNC(=O)CCCC(C)C)CCOC2)=C1 CC1=NC=CN1CCN=C(NCC2=CN=C3N2CCCC3)N[C@@H1]4CCS(=O)(=O)C4 COC(=O)[C@]1(C(=O)N(C)CCCNC(=O)CCCN2CCCCC2)C[C@H1]1C CC1=CC=CC(C(=O)N[C@H1]2CC[C@]23CCCN(C(=O)[C@H1]4SCC=C4C)C3)=C1 CN1CC2(CC(NC(=O)C[C@H1](NC(=O)C3=CC=C(C(N)=O)O3)C(F)F)C2)C1 CC1=CC(C)=C(Cl)C=C1C(=O)N(C)CC2(O)CN(C(=O)C(F)=C3CCC3)C2 CC=1C=CN(C)C=1C(=O)N2C[C@@H1]3CC[C@H1]([C@H1]2CO)N3C(=O)C(C)(C)CO CC1=CC(CNC(=O)C[C@H1]2CN(C(=O)C3CCCCC3)CCO2)=NN=C1C CC=1SC(Cl)=NC=1C(=O)NC2CC3(C2)C[C@H1]3NC(=O)C[C@@H1]4C[C@H1]4C5CC5 CCCCN1C=C(C(=O)N(CC)[C@@H1](C)CNC(=O)[C@@H1]2CSC3=CC=CC=C32)N=N1 C[C@@H1](CNC(=O)C1=CC=CC2=C1CCCO2)NC(=O)C3CC(Cl)(Cl)C3 C#CCN(C(=O)C1=CC=NC=N1)C2CCN(C(=O)[C@@H1](C)NC(=O)CC)CC2 CC1(C)C[C@H1](CNC(=O)CCC2=COC=N2)N(C(=O)C3=CN=C[NH1]3)C1 F[C@@H1]1COC2(CCN(C3=CC(NCC4=CC=C(Br)C(Cl)=C4)=NC=N3)CC2)C1 C[C@@H1]1C[C@@H1](C#N)CN1C(=O)CCC2=NC3=CC=CC(Cl)=C3[NH1]2 CC[C@H1]1CN(C(=O)C2=CCCC2)CC[C@@H1]1NC3=NC4=CC(F)=C(F)C=C4S3 C[C@@](CNC(=O)C1=CC=NC(Cl)=C1F)(NC(=O)C2=CC=C(F)N=C2)C3CC3 C[C@@H1]1CC[C@@H1](NC(=O)C=2[NH1]C=CC=2C3CC3)CN1C(=O)C4=CC=CN5N=CN=C45 CCN1N=C(C)C(C(=O)N2C[C@H1]3[C@H1](CNC(=O)C4=C(C)N=CN4O)[C@H1]3C2)=N1 CC[C@@H1](C(=O)N1CCC[C@]1(C)CNC(=O)C=2C=CC(=N)[NH1]N=2)C(C)C COCC(F)(F)C(=O)N1CCCC2(CC(NC(=O)[C@@H1](C)OCC(F)(F)F)C2)C1 CNC1=CC=C(F)C=C1C(=O)N2CC=C[C@H1](NC(=O)C#CC(C)C)C2 CC(=CC(=O)N1C[C@H1]2C[C@@H1]1[C@H1]2NC(=O)C[C@@H1]3CCCO3)C4=CC=CO4 C[C@H1]1C[C@@H1](C)N(C(=O)CCCC2CCC2)CCN1C(=O)C3=CC=C4SN=NC4=C3 CN1N=CC=C1C=2N=C([C@H1]3C[C@@H1]3C4=CC=CS4)N(C5=CC=C(F)C(F)=C5)N=2 O=C1CC(CO[C@H1](CNC(=O)CCS(=O)(=O)C2CCCC2)C)C1 CC(C)(C)[C@@H1]1CC[C@H1](NC(=O)C2=CC=3N=CN(C)C=3C=N2)C(=O)OCC1 CN1N=C(C(=O)N2CCC[C@H1]2C(C)(C)CNC(=O)[C@H1](O)C3=CC=NN3C)C=C1Cl O=C(NCCCF)[C@H1]([C@@H1]1C[C@]12CCOC2)N3CCC(O)(CC4CC4)CC3 CCC[C@@H1](N[C@H1]1CCN(C(C)C)C[C@@H1]1C#N)C2CCCC2 C[C@H1](C1CC1)N2C[C@H1](C(=O)N3CC(C)(NC(=O)[C@H1]4CCC[C@H1](F)C4)C3)CC2=O CC[C@](C)(CNC(=O)C=C[C@@H1]1CCOC1)NC(=O)C=2N=C(Cl)OC=2C CC1=CC=C(C(=O)N[C@H1](CNC(=O)CCC=2C=C(C)ON=2)C(C)(C)C)C(O)=N1 CC1CCC(CN(C=O)CC[C@H1]2CC=CCC2)CC1 CCN1C=NC(CN2CCN(C3=CC=C([N+1](=O)[O-1])C=C3C=O)CC2)=N1 CCNC(=O)[C@H1](C1=CC=CC(P(C)(C)=O)=C1)N2CCC[C@@H1]3C[C@@H1]3C2 CC1=C(C(=O)N2CC[C@H1]([C@@H1]3CCCN3C(=O)[C@@H1]4CC=CC5=CC=CC=C54)C2)CC1 CC=1OC(CO)=CC=1C(=O)N[C@@H1]2CN(C(=O)C3=N[NH1]C4=C3CCC4)CC[C@@H1]2CO C[C@H1]1CC(=O)N[C@@H1](C(=O)N2CC[C@@H1](C(=O)N3CC[C@H1](OCCF)C3)O2)C1 CC(C)[C@H1](C(=O)N[C@H1]1C=CCN(C(=O)CSCC2=CC=CS2)C1)N(C)C CCCC(CCC)CC(=O)NC1(C)CN(C(=O)C=2SC(Cl)=CC=2Cl)C1 O=C(NC1(C2=NC=CN2)CC1)[C@H1]3CC4(CCC4)CCN3 NS(=O)(=O)CCCC(=O)N1CC[C@](NC(=O)CC2=CC=CS2)(C3=CC=CC=C3)C1 C[C@@H1]1C[C@H1](NC(=O)CS(N)(=O)=O)CCN1C(=O)C2=CN(C3=CC=CC(Cl)=C3)C=N2 CCC1=NSC(CNC(=O)C=2N=C(CNC(=O)CS(C)(=O)=O)N3C=CC=CC=23)=N1 CN1N=C(C(=O)NCC2(CNC(=O)[C@@H1]3C[C@H1]3C4CC(F)(F)C4)CCC2)C(Cl)=C1Cl CC1=CC(C(=O)NNC(=O)C2=CC=CN=C2C)=C(N)C(Cl)=N1 CC1=CC=C(CCNS(=O)(=O)C2=CN=C(N[C@H1]3COC(C)(C)C3)C(Cl)=C2)S1 CO[C@@H1]1C[C@@H1](CNC(=O)C2=CC(C)=C(C)S2)N(C(=O)C=3C=CN(C4CC4)C=3C)C1 CN(CCF)CCN1CCC(=O)N(CC2=CC=C3N=CC=NC3=C2)C1=O CO[C@H1]1C[C@@H1](NC(=O)[C@@H1](O)CC2=CC=CC=C2Cl)CN(C(=O)CC3(OC)CC3)C1 C[C@H1](CCN(C)C(=O)C1=CC=CC2=C1NCC2)NC(=O)C3=CC=CC=4[NH1]C=CC3=4 O=C(NCC1(NC(=O)C=2N=C3C=CC(Cl)=NN3N=2)CCC1)C4=CC=C(Cl)C=C4F C=CCCCC(=O)N1CC[C@](CCOC)(NC(=O)C=2SC(CCCC)=NC=2C)C1 CCN1CCC[C@@H1](C(=O)N[C@H1]2C[C@H1](CN3C=C(CCS(C)(=O)=O)N=N3)C2)C1 CC1=CC=C(NC(=O)C2=CC=CC([C@@H1]3CC3(F)F)=C2)C(Cl)=N1 C[C@H1](C(=O)N1CC(CN(C(=O)C[C@@H1]2C=CCC2)CC3=CC=CC=C3O)C1)C4CC4 C[C@@H1](CNC(=O)COC1CC1)C2CCN(C(=O)C#C[C@@H1]3CCOC3)CC2 CC(C)COCC(=O)N1C[C@@H1]2C[C@H1]1[C@@H1]2CNC(=O)C3=CC=C4C=CC=C(F)C4=N3 CC=1C=C[NH1]C=1C(=O)N[C@H1]2CCC23CCN(C(=O)[C@@H1]4C[C@H1](F)C(=O)N4)CC3 COC1=CC=CC=C1[C@H1]2CN(C(=O)C3=CN=N[NH1]3)CCN2C(=O)[C@H1](F)C(C)(C)O O=C(NC[C@@H1]1CCCC[C@H1]1C(F)(F)F)N2CC(OC3=CC=CC=C3Cl)C2 CC(C)C[C@H1](C(=O)NC[C@@H1]1C[C@H1](C)CCN1C(=O)[C@H1](C)N2C=CN=N2)N(C)C CC=CC(=O)N[C@H1]1C[C@]2(CCCCN2C(=O)C=3[NH1]C(O)=NC=3C)C1 O=C(C=CC(=O)N1CCC[C@@](F)(CNC(=O)C=CCO)CCC12CCC2)C3CC3 CO[C@@H1]1C[C@@H1](CNC(=O)CCCCCC#N)N(C(=O)C=2C=C(C(C)(C)C)ON=2)C1 C=C1CC(C(=O)N(C)C[C@H1]2CN(C3=NC(CC4=CC=CC=C4)=NS3)CCO2)C1 C=CCOC(=O)NCC(=O)NC[C@H1]1COC[C@@H1]1NC(=O)C[C@@H1]2CC[C@@H1](C)O2 CC(=O)N1CCC[C@@H1]1C(=O)N2CCC[C@@H1]2CCNC(=O)C3CN(CC(F)(F)F)C3 CC[C@H1](C)NC(=O)[C@@H1](C1=CC=C(Br)C=C1F)N(C)CC2=CN=CO2 CCO[C@H1](CC)C(=O)N1CC(=O)NC[C@@H1]1C(=O)NC2([C@H1](O)CO)CC2 N#C[C@H1]1C[C@H1]1C(=O)N2CC[C@@]3(CCN(C(=O)C4=CC=C([N+1](=O)[O-1])[NH1]4)C3)C2 CO[C@@H1]1CN(C(=O)CCSC2=NC=CN2C)C[C@@H1]1NC(=O)[C@H1](F)C3CCOCC3 CCC1=NN=C(NC2CC(C=3C(C(F)(F)F)=NN(CC(C)C)C=3C)C2)C(C#N)=C1 CN1C=C(Cl)C=C1C(=O)N2CCC[C@@](F)(C(=O)NC[C@@H1](F)C3CCC3)C2 C[C@H1]1C[C@]1(C#N)C(=O)N2CC(O)(CNC(=O)C3(C)CCCCCC3)C2 COC=1C=C(C(=O)N2CCN(C(=O)[C@@H1]3CC[C@@H1](F)C3)[C@H1](C)C2)[NH1]N=1 CCCC(CCC)N1CC[C@H1](CC(=O)N[C@@H1](CO)C(=O)OC)C1 CC[C@H1](O)C(=O)NCCCC(C)(C)NC(=O)CCCC(F)(F)CO CC(C(=O)N1CC[C@H1](CN(C)C(=O)C2=CN=C(C(C)C)[NH1]2)C1)=C3CCC3 CCCCNC(=O)CO[C@H1]1CC1(F)F CCC(=O)NCC(=O)N1C[C@@H1]2CCC[C@H1](C1)CN2C(=O)CN3CSCC3=O CCCCC[C@@H1](O)C(=O)N1C[C@@H1]2C[C@H1]1[C@@H1]2NC(=O)[C@]3(F)CCOC3 CCN(CCNC(=O)CC1CC(C)C1)C(=O)[C@@H1]2CC3=NN=C(C)N3C2 C[C@@H1](CCNC(=O)C1=COC2=C1CSC2)N(C)C(=O)[C@H1](C)C(=O)OC(C)(C)C C#CCCC(=O)N[C@@H1]1CN(C(=O)C2=CC=C(F)C=C2SC)[C@H1]3CCC[C@@H1]13 C=C(Cl)CONC(=O)[C@]1(C)CN(C(=O)C2CC(C)(C)C2)C(C)(C)C1 CC(Cl)=CC(=O)NC[C@@]1(F)CC[C@H1](NC(=O)CC=2C=COC=2C)C1 CCC(C)(C)NC(=O)[C@H1](C1=CCSC1)N2C[C@@H1]3CC[C@]3(C(=O)NCC4CC4)C2 C[C@@H1](C(=O)N1CC2(CC(CNC(=O)[C@@H1]3COCCO3)C2)C1)C4=CC=C(F)C=C4F CC(=CC(=O)N1CC(N(C)C(=O)[C@H1]2C[C@H1](O)C2)C1)C3=CC=CC(Cl)=C3 CCCC1(NC(=O)[C@@H1](CNC(=O)C2=N[NH1]C3=CC=CC=C23)C(C)C)CC1 O=C(N[C@@H1]1C[C@@H1]1C(=O)NCC2=CC=C3[NH1]C=CC3=C2)C4=CC=C(Cl)S4 C=CC1(NS(=O)(=O)C2=CC=C(NC3COCCOC3)C(C#N)=C2)CCC1 C[C@H1](C(=O)N1CC(O)(CN(C)C(=O)[C@]2(C)CCC(=O)NC2)C1)N3C=NC=N3 CC1=CN=C(C)C(C(=O)N[C@H1]2COC[C@H1]2NC(=O)CC3=CCN(C)CC3)=C1 COC1=CC=CC([C@@H1](OC)C(=O)NCCN(C)C(=O)C2C[C@H1]3C[C@@H1]3C2)=C1 CCC(CF)(CF)N1C[C@@H1]2CN(C(=O)OC(C)(C)C)[C@H1](CO)[C@@H1]2C1 CCN(CC)CC1=CC=C(C(=O)N2CCCC[C@H1](NC(=O)CC3=CC=NO3)C2)O1 CCCC=1[NH1]C=CC=1C(=O)NC2CCC(CC(=O)N[C@@]3(C)CCCC[C@H1]3C)CC2 CNS(=O)(=O)C1=CC=CC(C(=O)OCC2=NOC(CCC(=O)OC)=N2)=C1 CCC=1N=C[NH1]C=1C(=O)N2CCSC[C@H1]2CCNC(=O)C[C@H1]3CCC(=O)NC3=O O=C(C[C@H1]1[C@@H1]2CN(C(=O)C3(CF)CC3)C[C@H1]12)N[C@H1]4C[C@@H1]5CCCCN5C4 N#C[C@]1(NC(=O)C2=CC=C3[NH1]N=C(I)C3=C2)CCN(C(=O)C4=CC=C(Cl)S4)C1 CC1=CC(C(=O)N2[C@H1]3C[C@H1]2CN(CC4=CC=C5C=CC=CC5=C4Cl)C3)=CC(O)=N1 CC(=O)NCCCC(=O)NC[C@H1]1C[C@H1](NC(=O)C(C)OC2=CC=C(Cl)C=C2C)C1 CN1CCCC[C@@H1](C(=O)N2CC3(C[C@@H1](NC(=O)CC4CCOCC4)CO3)C2)C1=O C/C=C/C[C@@H1](NC(=O)CC1=CC=CN=C1O)C(=O)N[C@H1](C)CCCCCC CCN(CC)[C@H1](C)C(=O)N[C@H1]1C=CCN(C(=O)C2OCCO2)C1 O=C(NCC1(O)CC(NC2=NC3=CC=CC(F)=C3O2)C1)C4C[C@H1]5C[C@@H1]5C4 O=C(N[C@H1]1C=CCN(C(=O)C2=CN=CC=C2Cl)C1)C3=NC=CC(Cl)=C3F C[C@@H1](CNC(=O)C1=CC=C(Cl)C(Cl)=C1)CNC(=O)[C@H1](C)C2=CC=CN=C2 NC1=C(O)N=C(O)N=C1C(=O)N[C@H1]2[C@H1]3[C@@H1](O)C[C@@H1]2CN3C(=O)CN4CCCCC4 CC(C)S[C@H1](C)C(=O)NCC1CN(C(=O)[C@H1]2CC(=O)N(CC(F)(F)F)C2)C1 CC1=CC(C(=O)N[C@H1]2CCC[C@@H1](NC(=O)C3=CC=C(CN(C)C)[NH1]3)CC2)=CS1 CC1=NNC(=O)[C@@H1]1CC(=O)N2CC=C[C@H1](C(=O)N[C@H1]3CCC4(CCCC4)C3)C2 CCCSCC(=O)N1CCC[C@]2(CCCN2C(=O)CC3=CN=C4C=CC=NN34)C1 CCC1=NON=C1C(=O)NC2CC3(CC(CNC(=O)[C@H1](C)[C@@H1](C)COC)C3)C2 CC(C)C1=CC=CC(C(=O)NC2(CO)CN(C(=O)C(C)(CO)CO)C2)=C1 CC[C@H1](O)[C@@H1](C)C(=O)N(CC)C[C@H1]1CCCCN1C(=O)CCC2CCCCC2 C[C@H1](C(=O)N[C@@H1](C(=O)N[C@@H1]1C[C@H1]1C#N)C2=CC=CC=C2)C3=CC=CC=N3 C=CC[C@H1](CC)C(=O)N1C[C@@H1](NC(=O)C2=C(C)C=C(C)N=C2S)CC3(CC3)C1 N#CC1=CC=C(C(=O)N2CC3(CCN(S(=O)(=O)C4=CC(Cl)=CC(Cl)=C4)CC3)C2)S1 CC(C)C[C@H1](C)C(=O)N1CCN(C(=O)[C@@H1]2CC3=CC=C(F)C=C32)C[C@@H1]1C(C)C COC1=CC=C2[NH1]C(=NCC3(CNC(=O)[C@@H1]4CNC[C@@H1](C(F)(F)F)O4)CC3)SC2=C1 C[C@@H1](NC(=O)[C@H1]1CCC[C@@H1]1C2CC2)[C@@H1]3C[C@H1]3C(=O)NCCCC4=CN=CN=C4 C[C@@H1](S)C(=O)N[C@](C)(C(=O)NC=1C=NSC=1)C2=CC=C(CCCO)C=C2 CC(C)[C@H1](NC(=O)C1=NC=CC=C1O)C(=O)N2CC3(CC[C@H1]2CO)CC3 CC[C@H1](C(=O)NC[C@]1(F)CCN(C(=O)C(C)(C)N(C)C)C1)C(F)(F)F CCNS(=O)(=O)CC(=O)N1CCO[C@@H1](CNC(=O)[C@H1](CC)CC(C)C)C1 CCC(CC)CCC(=O)N[C@H1](C)[C@@H1]1C[C@H1]1C(=O)NC[C@@]2(F)CCOC2 C[C@](O)(C(=O)NC[C@H1](C(=O)NCCCO)[C@@H1](C1=CC=CC=C1Cl)C)C2CCC2 N=C1N=NN(CC(=O)NC2(CNC(=O)C3=CN(CC(N)=O)N=N3)CC2)[NH1]1 COC[C@]1(C(=O)NC[C@@H1]2CC(C)(C)CN2C(=O)C=CBr)C=CCC1 COC(=O)[C@]1(C(=O)N[C@@H1](CNC(=O)C2=CC(C(C)C)=NO2)C3CC3)C=CCC1 CCC(=O)NCC(=O)N1CC([C@@H1]2CCCN(C(=O)[C@H1](CC)CC(F)F)C2)C1 CC1=CC(C(=O)N[C@H1](CNC(=O)[C@@H1]2C[C@H1]2C3=CC=C(Cl)C=C3)C4CC4)=CN=C1O C[C@@H1](CCNC(=O)C1=CC(Cl)=NO1)NC(=O)CN2CCCNC2=O C[C@H1](NC(=O)[C@@H1](C)C=1C=CN(C)N=1)C(C)(C)C(=O)NCC2(O)CCCCCC2 C=C=C(C)CC(=O)N1CCC[C@H1](CNC(=O)COC2=CC=CC=C2O)C1 CN(C)CCC1=CC=CC=C1C(=O)N2C[C@@H1]3C[C@H1](C2)CN3C(=O)[C@@H1]4CC[C@@H1](F)C4 CN1N=CC=C1C=CC(=O)N2CCC(CCNC(=O)[C@@H1]3C[C@@H1]4C=C[C@H1]3CC4)CC2 C[C@H1](N)C1=N[NH1]C(CC(=O)NC2=CC=C(C(=O)OC(C)(C)C)C(Cl)=C2)=N1 COCC1(C(=O)N2C[C@H1](C(F)F)[C@@H1](NC(=O)CC3=CN=NS3)C2)CCCC1 O=C(N[C@@H1]1C[C@@H1]2CN(C(=O)[C@@H1]3CCCC34CCC4)C[C@H1]21)C=CC5=CC=NC=C5 CSC1=CC=C(/C=C/C(=O)NCCOCCCN(C)C(=O)C2(O)CCOCC2)S1 CN(CC1CCN(C(=O)[C@@]23C[C@@H1](N=[N+1]=[N-1])[C@@H1]2C3)CC1)C(=O)[C@]4(C)CCCCO4 CC[C@H1](CNC(=O)CNC(=O)C1=CC=CC(O)=C1)NC(=O)C2(F)CCCCC2 CN1N=C[C@@H1](CC(=O)N(CCNC(=O)CC2=CN=NN2C)C3CC3)C1=O CCC(C)(C)C(=O)NCCCCCC1CCN(C(=O)[C@@H1](O)CN2CCCC2)CC1 CC=CCCC(=O)N[C@@H1]1CC[C@H1]1CNC(=O)CCC(=O)NCCNC(C)=O C=CCC[C@H1](CC(C)C)C(=O)N1CCN(C(=O)C2=CC=CC([S@@](C)=O)=C2)[C@@H1](C)C1 CCC[C@@](C)(O)CC(=O)NC1(CNC(=O)C2=C(C)OCCS2)CC(OC)C1 CSCC[C@@H1](CO)NC(=O)[C@H1]1C[C@@H1](NC(=O)C2=CC=C(Cl)C(C)=C2F)C1 C[C@@H1]1CCN(C(=O)[C@H1]2C[C@H1]3[C@@H1](C2)C3(F)F)C[C@@H1]1NC(=O)CC[C@@H1](C)N(C)C CC(C)(C(=O)NC[C@@H1]1C[C@@H1]2CCC[C@@H1]2N1C(=O)[C@@H1](O)C(F)F)C3=CC=CN=C3F CC1=CC(C)=NC(C(=O)N[C@@]23CCC[C@@H1]2N(C(=O)C=4OC(C)=NC=4C)CC3)=C1 C[C@H1](NC(=O)C(C)(C)C)C(=O)N(C)[C@H1]1[C@@H1]2CN(C(=O)CCCN(C)N=O)C[C@@H1]21 C[C@H1](NC(N)=O)C(=O)N[C@H1]1C[C@H1](O)CN(C(=O)[C@@H1]2CN3CCN2C[C@H1]3C)C1 CCCCCS(=O)(=O)CC(=O)N1C[C@H1](C)[C@@H1](NC(=O)[C@H1](C)CCC(C)(C)C)C1 C[C@H1](SC[C@H1]1CCCO1)C(=O)N2CCCC3(CN(C(=O)[C@H1]4C[C@H1](C#N)C4)C3)C2 CC=1C=C[NH1]C=1C(=O)N[C@@H1]2CN(C(=O)[C@@H1]3CCCC4=NC=C(C)N43)C[C@@H1]2C C=C1C[C@@H1]1C(=O)NC(C)(C)CCNC(=O)CC=C(C)CC2=CC=CC=C2 CC[C@@H1](C)NC(=O)[C@@H1]1[C@H1]2CC[C@H1](C2)[C@@H1]1NC(=O)[C@@H1](C)CCOC CCCN1C=C(C(=O)NCC2=CC=C(C(=O)N[C@@H1]3CCC[C@H1](CC)C3)C=C2)C=N1 CC[C@]1(C(=O)N=C2C=CN(C(C)(C)C)[NH1]2)CCCN1C(=O)C[C@H1]3CCCO3 CCC1=NN=C2C=C(N3CCC[C@]4(CNC(=O)C5=CC=CS5)CCC[C@@H1]34)N=CN12 COC(=O)[C@H1]1C[C@@H1](C(=O)N2CCN(CC3CN(C(=O)[C@@H1](C)CN(C)C)C3)CC2)C1 COCCNC(=O)CNC(=O)C=1OC=CC=1CNC(=O)C=2C=C(CO)ON=2 CCN(C[C@H1](C)NC(=O)CS(=O)(=O)CCOC)C(=O)[C@H1](C)OC1=CC=CC=C1F C[C@@H1](C(=O)N(C)[C@H1]1CC[C@@H1](NC(=O)CC2=CC=CN=C2Cl)CC1)N3C=CN=N3 CC[C@@H1](C)NC(=O)[C@@H1](CCC1=CC=CC=C1F)N2CCN3CCC[C@H1]3C2 NC(=O)C1=CN(CC(=O)NCC2(O)CC(NC(=O)C[C@H1]3CCC(=O)O3)C2)C(=O)N=N1 NC1=C(F)C=CC(F)=C1C(=O)N[C@@H1]2C[C@@H1]2NC(=O)C=3C=CN4C=NN=C4C=3 CC[C@@H1](CN(C)C(=O)C1=NOC=C1C)NC(=O)C2=CC=C(F)C(OC)=C2F CCCOC1=CC=C(C)C=C1C2=CC=C3C(=C2)CN(S(=O)(=O)C4CC(F)(F)C4)C3 CC=1SC=C(C(=O)N2CCOC[C@@H1]2CCNC(=O)[C@@]3(C)CC=CCO3)C=1C CC1=CC(C(=O)N2CC[C@@H1]3C[C@@]3(C(=O)NCCN(C)CC(F)F)CC2)=NO1 CCOC(=O)[C@H1]1C[C@](F)(C(=O)N2CC[C@H1](N(C)C(=O)C3C(C)(C)C3(C)C)C2)C1 CC1(C(=O)N2C[C@@H1](O)[C@H1](NC(=O)C3=CC(Br)=N[NH1]3)C2)CCOCC1 CCN1CC[C@H1]1C(=O)NCC#CCNC(=O)[C@H1]2CCCNC2 CCOC(=O)C1=CCN(C(=O)N[C@@H1](C2=NC(C)=NO2)C(C)C)C1 CC(C)=CCC[C@H1](C)CC(=O)NCC1(CNC(=O)[C@H1]2COC(C)(C)C2)CCCC1 CC(=O)N[C@H1](C(=O)N1[C@H1](CNC(=O)CCOC2CC2)C[C@H1]3COC[C@@H1]31)C(C)(C)C CC=1C=C(C(=O)N2C[C@@H1](NC(=O)[C@@H1]3CCCCS3)C4(CCCC4)C2)SN=1 CCS(=O)(=O)N(C)CC(=O)N1C[C@@H1](C)C[C@@H1](NC(=O)C2COC2)C1 C[C@@H1]1CCCN(C(=O)[C@H1](NC(=O)C=CCN2CCCC2)C3=CC=NN3C)[C@@H1]1CO C=CC[C@@]1(C(=O)N(CCO)CCO)CCCN1C(=O)C(N)=O COCCOCCNC(=O)CN(CCC1=NN=C(C2=CC=CC=C2)O1)C=O CN(CC(=O)NCCCCCO)C(=O)C[C@]12CCC[C@H1]1C2 CC=1C=C(CC(=O)N2C[C@@H1]3C[C@H1]4C[C@H1]3[C@@H1]2[C@H1]4NC(=O)C[C@@H1]5CC5(Cl)Cl)N(C)N=1 CCC1=NN=C(C2=CC=CC(S(=O)(=O)N3C[C@H1](C)S[C@H1](C)C3)=C2)O1 CC[C@H1](CNC1=NC=NC(N2C[C@@H1](COC)OC(C)(C)C2=O)=C1)N(C)C CC(C)[C@@H1](O)[C@H1](C)C(=O)N(C)CCC(=O)N1CCNC(=O)[C@@H1]1CCO CN1C=C(C[C@H1](O)C(=O)N[C@H1](CNC(=O)C2=CSC(Cl)=N2)C3CC3)C=N1 O=C(COC1CC1)NC[C@@H1]2COCCN(C(=O)CC[C@@H1]3CCCCO3)C2 CC1=CC=C2C=C(CNC(=O)[C@H1]3CCCNCC3)SC2=C1 C=CC(C)(C)N[C@]1(C2=NN=NN2C3CCC3)CC[C@H1](OC)[C@@H1]1OC CCCC[C@H1](O)[C@@H1](C)C(=O)N1CCO[C@H1](CNC(=O)[C@H1]2CN(CC)CCO2)C1 CC1=NOC(CCC(=O)N2[C@H1]3CC[C@@H1]2[C@@H1](F)[C@H1](NC(=O)C[C@H1]4CCC(=O)N4)C3)=N1 C[C@@H1](CC1=CC=C(O)C=C1)C(=O)NC[C@@H1]2C[C@H1]2CNC(=O)CC(F)(F)C(C)(F)F C=C[C@H1]1CN(C(=O)[C@H1](C)OC2=CC(C)=CC=C2Cl)C[C@H1]1NC(=O)C=3[NH1]C=NC=3C CC[C@H1](CCC1CCCC1)CNC(=O)C(=O)N[C@@H1]2COC(C)(C)C2 CCOC(=O)CC1=CSC(N2C=C(CN[C@@H1](CCO)C3CCOCC3)N=N2)=N1 C[C@@H1](C(=O)NCC1C2C(NC(=O)C3CC(CC(C)(C)C)C3)(CO1)C2)N4C=CC=C4 CCC=1OC=C(C)C=1C(=O)NCC(CC)(CC)NC(=O)[C@@H1](C)N2C=C(Br)C=N2 CC(=O)N[C@@H1](CC(=O)NC1(CO)CN(C(=O)[C@@H1]2CCC(C)(C)C2)C1)C(N)=O CCN(CCNC(=O)C1=CC=CN=C1F)C(=O)C(=CC2=CC=CC=C2)C(F)(F)F COC(=O)C1=COC([C@@H1](NC2=CN=C(C)C(C)=C2)C3=NN=NN3CC(F)F)=C1 COC1CC2(C1)CC(C(=O)NC[C@H1](CC(F)(F)F)NC(=O)C=3C(C)=NOC=3C)C2 C[C@H1](NC(=O)C1CCCC1)C(=O)N2CCCC[C@@H1]2CCNC(=O)C3=N[NH1]C(O)=N3 CCCN1N=CC=C1C(=O)NCC2(O)CN(C(=O)C(C)(C)C3CCC(O)CC3)C2 CCN(C(=O)[C@@H1]1CCCC1(C)C)[C@@H1]2CCCN(C(=O)CC3=C[NH1]N=C3O)CC2 COCCC[C@H1](C)C(=O)N1CC2(C=C(C(=O)NC[C@H1]3C[C@@H1](OC)C3)CO2)C1 CCOC(=O)C1=CN=C(CN2CC[C@H1](C3CCNCC3)C2)N=C1C(F)(F)F CC12CCC(C(=O)NCCN(CC)C(=O)C=3C=C(CO)ON=3)(CC1)OC2 O=C1CCC2=CC(C(=O)N[C@H1]3C[C@H1](F)CN(C(=O)CSC(F)F)C3)=CC=C2N1 C=C1CCC(C(=O)NCC[C@@H1]2CN(C(=O)C3=NN(C)C=C3C(C)=O)CCO2)CC1 CN=C1N=C(N(C)CCN2C=NC=N2)[NH1]C(=NCCN3C=C(C(=O)OC)N=N3)[NH1]1 COCCC1(C(=O)NCCCOC(=O)OC)CCN(C(=O)CC=2C=C[NH1]N=2)CC1 CCC1=NO[C@H1](CC(=O)N(C)C[C@H1](O)CN(C)C(=O)C2(S(N)(=O)=O)CCC2)C1 C[C@@H1]1C[C@H1](C(=O)NC/C=C/C2=CC=CC=C2)CCN1C(=O)[C@H1]3CCOC(C)(C)C3 CC1=COC(C(=O)OC[C@H1]2CCCN(C)C2=O)=C1 CC1=CC=C(C(=O)N[C@H1]2CCCC[C@@]23CN(C(=O)[C@H1]4C[C@@](C)(O)C4)CCO3)C=N1 C=C[C@@H1]1OCC[C@H1]1C(=O)N[C@@H1](C)C2=NC(C(=O)N3CC(OCCO)C3)=CO2 C[C@@H1]1CCCN1CC(=O)N(C)C[C@@H1]2CCN(C(=O)C3=CC=C(C(C)(F)F)C=C3)C2 CN1C=NC=C1C=CC(=O)N2C[C@@]3(CNC(=O)CC=C(Cl)Cl)C[C@H1]2CO3 NC(=O)[C@@H1]1C[C@@H1]1C(=O)NCC2(CCNC(=O)C3=CC(Cl)=CC([N+1](=O)[O-1])=C3)CC2 CCC=1[NH1]C=CC=1C(=O)N[C@H1]2C[C@@](F)(CNC(=O)CC3=NON=C3C)C2 C[C@@H1]1CCN(C(=O)[C@H1](CNC(=O)C2=CC=CC(CC#N)=C2)OC)CC1(C)C COC1=C(F)C=CC(Br)=C1C(=O)NCC2(CCNC(=O)[C@H1]3COC(=O)C3)CC2 O=C1CC[C@H1](C(=O)N2C[C@H1](NC(=O)C3=CC(Cl)=CC(Cl)=C3)CC(F)(F)C2)CCO1 CC1=CN=C(C(=O)N2C[C@@H1]3C[C@H1](NC(=O)C4=CC=NC(O)=C4)C[C@@H1](C3)C2)C(O)=C1 COCCSCC(=O)N[C@H1](C)C(C)(C)NC(=O)C1=CC(C)=C(O)C(N)=C1 CC[C@@H1]1CCN1C(=O)[C@H1]2C[C@H1](O)[C@@H1](NC(=O)[C@H1](O)CN3C=NC=N3)C2 O=C(N[C@@H1](CN1C=CN=C1)C2=CC=CC=C2)N[C@@H1]3CCCC3(F)F CC[C@@](C)(CNC(=O)C1=CN=CC(C(C)C)=C1)NC(=O)C2=CN=C(S)[NH1]2 CC1=CC(C(=O)N2CC[C@H1](C3=CN(C4=CC=CC=C4CO)N=N3)C[C@H1]2C)=C(C)S1 CCC1=CC=C(Cl)C(C(=O)NCCC2(O)CN(C(=O)C=CC3=NC=CS3)C2)=C1 CC1=CC(=NC[C@@]2(C)C=CCCC2)[NH1]C(=NCCCC3CC(C)C3)[NH1]1 C#CCCC(=O)N1C[C@@H1](C)[C@H1](CNC(=O)[C@@]2(C)COC(=O)N2)C1 CON=CC(=O)N[C@H1]1[C@H1]2C[C@H1](CN(C(=O)C3=CN4C=CC=CC4=N3)C2)[C@H1]1CO C[C@H1]1CCCC[C@@]1(CNC(=O)C(C)(C)O)NC(=O)CC2=CSC3=NC=CN23 C[C@H1]1C[C@@H1](NC(=O)CCOC2=CC=CC=C2Cl)CN1C(=O)CCN3C=C(Cl)C=N3 C/C=C/CCNC(=O)CC1(N(C)C(=O)CCC2(C)CC2)CC1 C#CC1=CC=C(C(=O)N[C@@H1]2C[C@@]3(NC(=O)[C@@H1](C)C/C=C/CC)CO[C@@H1]2C3)C=N1 CC[C@@H1](C)[C@H1](O)CC(=O)N(CCNC(=O)C1=CC(C)=NO1)CCC2=CC=CC=C2 C=CCCC(=O)NCC1CCC(C(=O)NC2=CN=CC(CO)=C2)CC1 CC(C)=CCC/C=C/C(=O)N1CC[C@@H1](N(C)C(=O)[C@H1](C)OC2=CC=CC(F)=C2)C1 C=CCCCCCCCC(=O)N1CCN(C(=O)C2=N[NH1]C=C2OC)C[C@@H1]1CCC CCN(C(=O)[C@H1](SC)C(C)(C)C)[C@@H1](C)C(=O)N[C@@H1](C)[C@H1]1CCC[C@H1]1O CCN(CC)C(=O)CCC(=O)N[C@@](C)(CNC(=O)C=1N=CSC=1C2CC2)C3CC3 CN(C)C=1N=C(C(=O)NCC2(F)CCN(C(=O)C34CC(F)(C3)C4)CC2)[NH1]C(=N)N=1 O=C(C1=CN=CC(Br)=C1Cl)N2CC[C@]3(C[C@@H1]3C(=O)N4CC[C@@](F)(CO)C4)C2 C[C@@H1](NC(=O)CCC(=O)NN(C)C)[C@@H1]1CCCN1C(=O)C2=N[NH1]C3=C2CCCC3 CCOC1(C(=O)NC[C@H1](C)NC(=O)CNS(=O)(=O)NC)CCSCC1 COC1CCC(CC(=O)N(C)C[C@H1]2CCCCN2C(=O)C3=CSN=C3C)CC1 CC1(C)[C@@H1](CNC(=O)NC2CCN([C@H1]3CCOC3)CC2)C1(F)F C[C@@H1](NC(=O)C1=CC=C(Br)O1)C(=O)N[C@@H1]2[C@H1]3C[C@@H1]2N(C(=O)[C@@H1]4C[C@@H1]4C#N)C3 C=CCOCC(=O)NCC(C)NC(=O)C1=CC=C2C(=C1)CC(C)(C)C2 CN(C[C@H1](O)C1CCC1)C(=O)/C=C/CC(C)(C)NC(=O)[C@H1]2C[C@H1](N=[N+1]=[N-1])C2 C[Si]1(C)CCN(CCNC(=O)C2=CC=C(OC3=CC=C(Cl)C=C3Cl)C=C2)CC1 CC[C@H1](O)C(F)(F)C(=O)NC/C=C/CNC(=O)C1(NC(N)=O)CCCCC1 CNC1=CC(OCC(=O)N2C[C@@H1]3CC[C@]3(CC(=O)NC4(CO)CCCCCC4)C2)=N1 C=CCCN1N=C(CN2N=CC=N2)N=C1C3=CN=C4C(=C3)C(O)=NC(=O)N4C CCC1(C)CC(C(=O)N[C@H1](C(=O)N2CCC(C)(C)CC2)C=3C=NN(C)C=3)C1 COC=1C=C(C)SC=1C(=O)N[C@@H1]2[C@H1]3C[C@@H1]2N(C(=O)C4=CC=CC=C4CC(C)C)C3 C#CCC[C@H1](NC(=O)[C@@H1](C)N(C)C(C)=O)C(=O)N1CC[C@@H1](C)C[C@H1]1C CCN(C[C@H1](C)NC(=O)C(C)(C)CF)C(=O)CSC1=CC=C(C(F)(F)F)C=N1 O=C(N[C@H1]1CC[C@H1](NC(=O)C2(C3CCC3)CCC2)C1)[C@@H1]4CN5CCN4CC5 CCC(SC)C(=O)N1C[C@@H1](NC(=O)C2(CN(C)C)CC2)CC3(CC3)C1 C[C@](O)(CNC(=O)[C@@]12CC[C@@H1](CN(C(=O)C[C@@H1]3C=CCC3)C1)C2)C4CCCC4 C=CC[C@H1](C)C(=O)NCC1(NC(=O)CC2=CC=NC(OC)=C2)CCCCC1 CCCCC(=O)N1CC[C@@](C)(NC(=O)C=2C=COC=2CC(N)=O)C1 C=CCOCCNC(=NCC)NCC(C)(C)OC(C)C O=C(C1=CCC1)N2CC3(C(NC(=O)C4(C=5N=N[NH1]N=5)CC6(CCC6)C4)C3)C2 O=C(N[C@@H1](CO)C1=CC=CC(Br)=C1)C2(CN=C3C=CN=C(C4CCC4)[NH1]3)CC2 CN1C[C@@H1](O)[C@H1](CC(=O)N[C@H1]2C[C@@H1](CNC(=O)CCC#N)C2)C1 CCCN(CCNC(=O)[C@H1]1CCN(C(=O)CCC(CF)CF)C[C@H1]1O)C(C)C COC(=O)[C@H1](CCC(=O)OC(C)(C)C)NC(=O)C1=CC(C)=C(C)N=N1 C=C[C@](C)(CC)C(=O)N[C@@H1](CO)CNC(=O)C1=CSC(C2=CC=NC=C2)=N1 O=C(NCC[C@H1]1CCCN1C(=O)CC(F)(F)C(F)(F)F)[C@H1]2CCCSS2 CCNC(=O)CC(=O)N1CC[C@H1](CCC(=O)N(C)CC[C@H1](O)CO)C1 COC1=CC=CC(C(=O)N2CC3(C2)CN(C(=O)[C@H1]4C[C@@H1](O)CN4C)CCO3)=C1 CS[C@H1](C(=O)N1CC[C@H1](C)[C@@H1]1CNC(=O)C(C)(C)O)C2=CC=CS2 C=CC[C@H1](CC)C(=O)N(C)[C@@H1]1CCCN(C(=O)[C@@H1](SC)C2CC2)CC1 CCC1=CC=CC=C1C(=O)N[C@H1]2CCC[C@H1]2CNC(=O)[C@H1]3C[C@H1](O)C3 CN1N=C([N+1](=O)[O-1])C=C1C(=O)N[C@@H1]2[C@H1]3CCN(C(=O)C4CCOCC4)[C@H1]32 C#CCN(C(=O)C[C@H1](N)CC1=CC=C(Br)N=C1)[C@H1](C)CC2=CC=CC(F)=C2 CN(CC(=O)N1CCCC[C@]2(CCN(C(=O)C3=CC(N)=CC(N)=C3)C2)C1)C(N)=O CCC=1N=N[NH1]C=1C(=O)N[C@H1]2CS(=O)(=O)C[C@@H1]2NC(=O)CCOC CO[C@H1]1CC[C@@H1](C(=O)N2CCC3(CC(NC(=O)C45CCC(C)(CC4)OC5)C3)C2)C1 C=CC1(C(=O)N[C@@H1](C)[C@H1](CO)SC)CCN(C(=O)CCOCC2CCC2)CC1 CCC1=CC=CC=C1[C@H1](CNC(=O)CCC=2C=C(C)[NH1]N=2)NC(=O)C(OC)OC CCC=1[NH1]C=CC=1C(=O)N2[C@@H1]3CN(C(=O)[C@H1](O)C4=CC=CC(Br)=C4)C[C@@H1]3C[C@H1]2C CC[C@@H1](CNC(=O)CN1CCNC(=O)C1)NC(=O)C2=NOC(C)=C2C(=O)OC CC1=COC(C(=O)N[C@@H1]2C[C@H1]3CC[C@H1]2CN3C(=O)C4(C)C(C)(C)C4(C)C)=C1 CC(=O)N1CCCCC[C@H1]1C(=O)NC2=NC(Cl)=CC3=N[NH1]C=C23 CC=1N=CSC=1C2=CN(CC3(O)CCN(C(=O)[C@@H1]4COC(=O)N4)CC3)N=N2 CC(C)(N[C@H1]1CC=2N=CSC=2CC1)C3CCOCC3 COC1=CC=CC=2C(C(=O)N(C)CC3=CN(C)N=C3C(F)(F)F)=CSC1=2 C[C@@H1]1CC[C@@H1](C)N1C(=O)C2=CN=C(CNC(=O)CC3(O)CCCC3)N=C2 COC(=O)[C@@H1]1C[C@@H1]1C(=O)N2C[C@H1]3CN(C(=O)C4=CN=CS4)C[C@@]3(C)C2 C[C@@H1]1CN(C(=O)CNC(=O)C2=CC=CC([N+1](=O)[O-1])=C2)C[C@@H1]1NC(=O)C=3C=CSC=3 CCCOC1=CC=NC(CC(=O)N2C[C@H1]3CN(C(=O)C4(Cl)CC4)C[C@H1]3C2)=N1 C[C@H1]1CCCCN1C(=O)C[C@@H1](C)CNC(=O)COC2CC=CC2 CC[C@](C)(C(=O)NCCC1(OC)CN(C(=O)[C@H1]2CCS(=O)(=O)N2)C1)C(F)F C=C(F)C(=O)N[C@@H1]1CCN(CC2=CC=CC(O)=C2[N+1](=O)[O-1])C1 C[C@H1](CO)CCNC(=O)[C@]1(C)CCCN1CC2=CC=CC(S(C)(=O)=O)=C2 NC1=CC(CC(=O)NC2(CO)CCN(C(=O)[C@@]34CC[C@@H1]3C4)CC2)=CC=C1[N+1](=O)[O-1] CCC1=NOC=C1C(=O)N2CCO[C@](C)(CNC(=O)C[C@H1](C)C(C)C)C2 C=CN1N=CC=C1C(=O)N[C@H1]2CCCC[C@@H1]2NC(=O)C[C@H1]3COCC4(CCC4)O3 C#CC1(O)CN(C(=O)[C@@H1](NC(=O)C(=O)[C@@H1](C)CC)C2=CC=CS2)C1 CC(C)N1CCN(CCC(=O)NCC#CCNC(=O)C2=NC=CN2C)CC1 CCOC(=O)C1=CN=C(NCC2=NC(CNC(=O)C=CC3=COC=N3)=CS2)C=N1 CC1(C)OC2(C(=O)N3C[C@H1]4CC[C@@]4(CNC(=O)C5=CC=6SC=CC=6[NH1]5)C3)CC1C2 CC(C)(C)CCCC(=O)NCC(C)(C)CC(=O)N[C@@H1](CC1CC1)C2CC2 N#CC1=CC=CC=C1S(=O)(=O)N2CC[C@@H1]3CN(C(=O)[C@H1]4C[C@H1]4F)C[C@H1]3C2 CC(C)=CC(=O)N1CCOC[C@H1]1C2=CC=C(C(=O)NC3(CCCF)CC3)N2C CC[C@H1](CN(C)C(=O)C1=CN=C2C=CC(C)=CC2=C1)NC(=O)CC=3C=CSC=3C CO[C@](C)(C(=O)N1CC[C@@H1](C)N(C(=O)[C@H1](F)C(F)(F)F)CC1)C2=CC=CC=C2 C=CC[C@H1](CC(F)F)C(=O)N[C@H1]1C[C@H1](NC(=O)C2=NC=CC=C2C)C13CCC3 O=C1C[C@H1](C(=O)NC2([C@H1]3CCCN3C(=O)C=CC4=CN=CC=N4)CC2)CO1 C[C@@H1]1C[C@H1](C(=O)NCC2(C)CCC(NC(=O)C=3OC=NC=3C4CC4)CC2)CCO1 O=C(NC1=CC=NC=N1)C2=CN=C(C3=CC=CC(C4(CO)CC4)=C3)C=N2 CC1(C)CC[C@@H1](CNC(=O)C=2C=CN(C(F)F)N=2)N(C3=CC=C(C(N)=O)C=N3)C1 O=C(N[C@H1]1CCC[C@H1]1N2C=C(COC3=CC(F)=CC(F)=C3)N=N2)C(F)(F)C(F)F CC[C@](CO)(OC)C(=O)N1C[C@H1](C)O[C@H1](C(=O)N[C@H1]2CCCN3N=CN=C32)C1 COC(=O)[C@H1](C)C(=O)N1C[C@H1]2CC[C@H1]1C[C@H1]2NC(=O)CNS(=O)(=O)N(C)C C[C@H1]1CC[C@@H1](NC(=O)C2=C(O)C=CC=C2O)CN1C(=O)C3=CC=CC(Cl)=N3 CC(C)[C@H1](C#N)C(=O)N1CC=C[C@H1]1CNC(=O)CC2(C=3C=CON=3)CC2 CO[C@H1](CCNC(=O)[C@H1]1CN(C(=O)CC2(CSC)CC2)CC13CC3)C(C)C C#CC1=CC(C(=O)N2C[C@H1](NC(=O)C(C)=CC)[C@H1](C3=CC=CC=C3)C2)=CC=C1C COCCN(CC(=O)N(C)[C@H1]1CC2CCC1CC2)C(=O)C=3N=CN(C)N=3 CC1=NC(C(=O)NC[C@H1]2C[C@H1](NC(=O)C3(N(C)C)CCOCC3)C2)=C(C)O1 C=C[C@]1(C(=O)N2CCC[C@H1](OCCC)C2)CCN(C(=O)CC3C[C@H1]4C[C@@H1]4C3)C1 COC1=CC(O)=CC=C1NC(=O)[C@@H1]2CCCN(C(=O)C3=CC=C(Br)C=C3I)C2 CCSCC(=O)N[C@H1]1CCN(C(=O)CC2=C[NH1]N=C2C)C[C@H1]1CO O=C(C[C@@H1]1CN2CCC1CC2)NC[C@@H1]3CCC4(CCN(C(=O)C5COC5)CC4)O3 C=C[C@@](C)(O)CC(=O)NC1(CN(C)C(=O)C(C)(C)CC2=CC=CC=C2)CC1 CC=1N=C(CO)OC=1C(=O)NCC2CC(NC(=O)C3=CC=C(C4CC4)C=N3)C2 C#CC[C@](C)(CC)C(=O)N[C@H1](C)CC1=CC=CC(OC(F)(F)F)=C1 COC1=CC=NC(C(=O)N(C)[C@H1](C)CCNC(=O)[C@H1]2CC3CCC2CC3)=C1OC CCCN(CC(=O)N(C)CC1(N(C)C)CCC1)C(=O)[C@]23CSC[C@@H1]2C3 CCN1C(C(=O)N[C@H1](C(C)C)C2CCN(C(=O)COCCF)CC2)=CN=C1O CC1=C(CC(=O)NCCNC(=O)[C@H1]2C[C@H1]3C=C[C@H1]2C3)C=NN1C CC1=CC=C(CSCC(=O)N2[C@H1](CNC(=O)C(C)(F)F)C[C@@H1]3COC[C@H1]32)C=C1 C=CCC[C@H1](NC(=O)[C@H1]1CCC(=O)N(C)C1)C(=O)NC[C@H1]2NC(=O)NC2=O COCC1=CC(C(=O)NC2(CCNC(=O)C=3C=NSC=3C)CC2)=NO1 CC[C@H1](NC(=O)[C@H1]1C[C@H1](C)N1C(=O)C2=CC(C)=CC(C#N)=C2)C(=O)OC CCC=1ON=CC=1C(=O)N(CCCNC(=O)[C@H1]2CCSC3=CC=CC=C32)C(C)C CCC1=NON=C1C(=O)N2C[C@@H1](N(C)C(=O)CN3[NH1]C=NC3=N)C4(CC4)C2 N#CCOC1=CC=C(CN[C@@H1]2CO[C@@H1](C3=CC=CC=C3)C2)C=C1 CC1=CC(=NC[C@@H1]2CCCCO2)[NH1]C(N[C@@H1](CO)C3=NC=C[NH1]3)=N1 CCCC=1C=C(C(=O)N2CCN(C(=O)C3=CC=CC(=O)O3)[C@@H1](C(F)F)C2)SC=1C CO[C@@H1]1CCC[C@@H1](C(=O)N[C@@H1](C)C2CN(C(=O)C3=CC(F)=C(N)C=C3F)C2)C1 CN(CC(F)(F)Br)C(=O)C(=O)NC[C@H1](O)C1=CC=C([N+1](=O)[O-1])C=C1 CCCCC(CCCC)NC(=O)CC1CCN(C(=O)C2=CC=NC(O)=C2F)CC1 CC1(C)CC[C@H1](CCNC(=O)C(C)(C)C2=CC=C(Br)C=N2)OC1 O=C(N[C@H1]1C[C@@H1]1CNC(=O)C2(C(=O)NC3=CC=CC=C3)CC2)C4=CN=CC(O)=C4 C[C@H1]1C[C@@H1](CCNC(=O)C2=CC(C#N)=CS2)CCN1C(=O)COCC3CCC3 CSCCN1N=NN=C1[C@]2(NCC3=CC=C([C@H1](C)O)C=C3)CS[C@H1]4CCC[C@H1]42 C[C@H1](F)CC(=O)N1CCC(CCC(=O)NCC=2C=NN(CCO)C=2)CC1 CC1(C2=CC=C(NC(=O)N3CCN(C4=CC=CC=C4O)CC3)C=C2)OCCO1 CC1=CN=C(CC(=O)N[C@@H1]2C=C[C@H1](CNC(=O)C3=C(Cl)N=C4C=CC=CN34)C2)O1 C=C[C@](C)(CC)NC(=O)[C@@H1](NC(=O)C1=CC=NN1COC)C(C)(C)O CCOC(=O)C=CC(=O)N1CC=C[C@@H1]1CNC(=O)CC2(NC(C)=O)CCCCC2 C[C@@H1]1C[C@@H1](NC(=O)C2=CN(C)[NH1]C2=N)CCN1C(=O)[C@H1](F)C(F)(F)F CN1N=CC=C1CNC(=O)[C@H1]2CC[C@H1](O)CN2C(=O)C3=CCCCO3 COC1=CC=C(C(=O)N2C[C@H1](C)N(C(=O)[C@H1]3CC3(C)C)[C@H1](C)C2)C=C1N CC(C)=C(F)C(=O)N1CC[C@H1]2CCN(C(=O)[C@H1](F)C3CCOCC3)C[C@H1]21 CC(=O)N1CC(C(=O)N(C)CCOCCCNC(=O)[C@@]23C[C@@H1](O)[C@@H1]2C3)C1 O=C(NCC1=NOC(C2CC2)=N1)[C@@H1]3C[C@@H1]4CN(C(=O)CCCF)C[C@@H1]4C3 COC[C@]1(C)C[C@H1](NC(=O)C2=CC(OC)=CN=N2)CN1C(=O)CC3=NC=CN3C C/C=C/[C@H1]1CN(C(=O)[C@H1](C)C#N)C[C@@H1]1C(=O)N(C)CCCN2CCCC2 C=CCCCCN(C)C(=O)[C@@H1]([C@@H1](C)CC)N(C)C(=O)[C@H1]1CN2CC[C@H1]1C2 CSC1=CC=C(C2=N[NH1]C3=C2CN(C(=O)[C@@H1](C)C4=CC=CC=C4)C3)C(C)=C1 COCCN(CCNC(=O)C[C@@H1]1CCNC1=O)C(=O)[C@H1]2CCN3C=C(C)N=C3C2 CO[C@@H1]1C[C@@H1](CNC(=O)/C=C/C2=CC=C(C)N=C2)N(C(=O)C3=CCCC3(C)C)C1 CC[C@]1(CNC(=O)[C@@H1](C)CNC(=O)CN2CCC(=O)CC2)CCOC1 C[C@@H1]1CCCC2=CC(C(=O)N3C[C@@H1]4C[C@H1](C3)CN4C(=O)[C@H1]5C[C@H1]6CC[C@H1]5O6)=NN21 CCC[C@H1](CC(=O)N[C@H1](C)C(F)F)NC(=O)[C@H1](C)CC(C)(C)C CC=1SC(=O)N(CC(=O)N[C@H1](C(=O)N(C)C)C2CCCC2)C=1C CCN(C)CC(=O)N1C[C@H1](N(C)C(=O)C=C2CCCCC2)C(C)(C)C1 C[C@H1](CNC(=O)[C@H1]1C[C@@H1](C)C2=NC(C)=CN2C1)NC(=O)CC3CSC3 C#CC1=CC=C(C(=O)N(C)CCCC(=O)N[C@@H1](CO)[C@@H1]2CCOC2)C=C1C O=C(CN1N=CC(O)=NC1=O)N[C@@H1]2COCCN(C(=O)[C@@H1]3CCC4(CC4)C3)C2 CC(C)(C)C(=O)N1CC[C@@](C)(NC(=O)C=C[C@H1]2COC(C)(C)O2)C1 CC=1[NH1]N=C(Cl)C=1C(=O)N[C@]2(C)CCCN(C(=O)C3=CC([N+1](=O)[O-1])=C(C)S3)C2 CC(=CC(=O)NCC[C@@H1]1CCN(C(=O)[C@@H1]2CCC3(CCOCC3)CO2)C1)C(F)F CCC(C)(C)[C@H1](OC)C(=O)N1CCN(C(=O)CC23COC(C2)C3)C[C@@H1]1CO COC(=O)[C@@H1]1[C@H1]2CN(C(=O)[C@@H1](CO)NC(=O)C3=CN(C)N=C3C)C[C@H1]21 O=C(C1=CN=NS1)N2CC3(CCN3C(=O)[C@@H1](O)CC4CCCCC4)C2 COC1=CC=CC=C1SCNC(=O)[C@H1](C=2SC3=C(Cl)C=CC=C3C=2C)N(C)C CCC[C@H1]1C[C@@H1]1N=C2[NH1]C(=N[C@@H1]3COC(C)(C)C3)C4=CC=C(C)C=C4[NH1]2 CN(C(=O)[C@@H1]1CCNC1=O)[C@@H1]2CCCN(C(=O)CC3=CC(C4CC4)=NO3)C2 C=CC[C@]1(NC(=O)C=2C=C(O)N(CC)N=2)CCN(C(=O)C[C@@H1](CC)CN(C)C)C1 CC(C)N(CCCNC(=O)CNC(=O)CC1CCCC1)C(=O)[C@H1]2CCC[C@H1](C)C2 C[C@H1]1CN(C(=O)C2=CC=NC(C3CC3)=N2)C[C@@H1]1NC(=O)C4=CC5=CC=NC=C5[NH1]4 C[C@@H1](C(=O)NC[C@@H1]1CN(C(=O)CCC(F)(F)F)CCC1(F)F)C2=CC=CC=C2F CC1(C)OC(=O)N[C@H1]1C(=O)N2CCOC[C@@H1](C(=O)NCCN=S(C)(C)=O)C2 CN(C[C@H1]1CCCN1C(=O)C2=CC=NN2C)C(=O)C3=NC=C([N+1](=O)[O-1])N3C CC1=CC(Cl)=C(C(=O)N[C@H1]2CCC[C@H1]2NC(=O)[C@@H1]3CCOC(=O)CC3)C=C1F CO[C@H1](C)CCC(=O)N[C@@H1]1CCN(C(=O)[C@@H1]2[C@H1]3CC[C@H1]32)CC1(C)C CCN(CCNC(=O)C1=CCC[C@@H1]1C)C(=O)C2=CN=C(C3CCC3)N=C2O CC(C)CSCCCN1C=C([C@@H1](CO)NC(=O)[C@H1](O)CC2=CN=C[NH1]2)N=N1 CCC1=NC(C(=O)NCC2(NC(=O)[C@H1](CC)CC(C)C)CCCCCC2)=CO1 CCN1N=CN=C1[C@H1](C)NC(=O)[C@H1](CN=[N+1]=[N-1])NC(=O)[C@@H1]2CC(=O)CS2 C[C@@H1](SC1=CC=C(F)C=C1)C(=O)N[C@@H1](C2=CC=CC=C2)[C@@H1](C)N CCOC(=O)C1=C[NH1]C(=NNC(=O)[C@H1](C)C2=CC=C(OC)C(OC)=C2)C=N1 COCC1=NN=C(CNC(=O)C(=O)NC=2C=NN(C(C)C)C=2C3CC3)S1 C=C[C@H1](N)C(=O)N1CCN2C=NC(C3=CC=CC=4C=COC3=4)=C2C1 C=C1CC(CNC(=O)CNC(=O)OC)(C(=O)NC[C@@H1](C)CCCC(C)C)C1 CC(C)CCCCC(=O)N1[C@@H1][C@H1](C2=NC=CN2C)C1(C)C COCCCN1N=NN=C1[C@]2(NCC3=NN(C)C=C3CO)CCOC[C@H1]2C CC(=O)OC[C@@H1](CO)NC(=O)[C@@H1](CNC(=O)C=1C=C(C#N)N(C)N=1)C(C)C COC(=O)CCC(=O)N(CCNC(=O)[C@H1](C)OC1=CC=CC(F)=C1)C2CC2 C=CC[C@@H1](C)C(=O)NC[C@@H1](F)CNC(=O)C1=CC(Cl)=NO1 CC[C@@H1](CC(=O)NCC(C)(C)NC(=O)C1=CC2=CC(Cl)=C(Cl)C=C2[NH1]1)C3CC3 C[C@H1]1CC[C@@H1](O)CN1N2CC(CN3C=CC=CC3=O)C2 CO[C@@H1](CCSC)C(=O)N1CCC[C@@](F)(CNC(=O)C2=CC(C)=NC(O)=N2)CC1 CSCC1(CC(=O)N2CCCC[C@@H1](NC(=O)CC(F)(F)C(F)(F)F)C2)CC1 C#CCCOCC(=O)N[C@H1]1CC[C@H1](CNC(=O)[C@@]23CC[C@@](CF)(C2)OC3)CC1 CCOC(=O)[C@H1]1C[C@](F)(C(=O)N2CC[C@H1](OCCNC(=O)[C@@H1](CC)CO)C2)C1 O=C([C@@H1]1CC12CC2)N3CCCO[C@@H1](CCNC(=O)C(F)(F)C4CCOCC4)C3 CCCC(C)(C)C(=O)NCCC1(CNC(=O)CC2=CC=C(O)N=C2)CC1 CC1=CC(N[C@H1]2CN(C)C[C@@H1]2C3=CC=CC=C3)=CN=N1 C[C@H1](O)[C@@H1](C)C(=O)N1CC(N(C)C(=O)C2=CC=CC(C(F)(F)F)=C2F)C1 CN(C)CC(C)(C)C(=O)N1CCC2=CC=CC=C2[C@H1](NC(=O)[C@H1]3CC=CCC3)C1 CC(=O)NC1=CN=C(C)C(C(=O)N(CCN(C)C)CC2=CC=CO2)=C1 O=C(O)[C@H1]1CCN(C(=O)CC2=CC=C(O)C=C2Cl)[C@H1](C3CC3)C1 C[C@@H1]1C[C@H1](CNC(=O)[C@@H1]2CC3(CC3)CN2C(=O)C=4N=NN(C)C=4N)CCO1 CO[C@@H1](C(=O)N[C@@H1](C)CCCNC(=O)C=1C=C(C2=CC=CC(F)=C2)OC=1C#N)C=N CCN1N=C(C)C=C1C(=O)N[C@H1](CO)[C@@H1](C)NC(=O)[C@H1](C)CCC2=CC=CC=N2 CCOCCCCCC(=O)N1C[C@@H1](C(=O)NCCCCSC)CCC1(C)C CC[C@H1](C)CCCCC(=O)NC[C@H1]1CCCN1C(=O)C(C)(C)[C@@H1]2CCCO2 CC[C@@H1](C)NC(=O)[C@@H1](CC1=CC=CC=C1Br)N(C)CC(=O)NCC2=CC=CS2 C[C@@H1]1[C@@H1](C)N(C(=O)C2=CN=C(C(C)(F)F)S2)CCN1C(=O)C=CC3=CN=CC=N3 CC=1N=NSC=1C(=O)N[C@@H1](C)C2CCN(C(=O)C=CC3=NC=CS3)CC2 CN(C)C(=O)C(=O)N[C@@H1]1COC[C@H1]1N2CCN(C(=O)C3=CC(Cl)=NN=C3O)CC2 CCC1=C(C(=O)NC[C@H1]2C[C@@H1]2NC(=O)C(C)(C)OC)CCCO1 CC=1N=C(CC(C)C)SC=1C(=O)NC[C@H1]2CCCN2CC3=CC=C(Br)S3 COC1=CC=CC=C1CC(=O)N([C@H1](C)[C@H1]2CCCN2)[C@@H1]3C[C@@H1](OC)C3(C)C CO[C@H1](CC1=CC=CC=C1)C(=O)NCC2CC(NC(=O)C3([C@H1]4CCCO4)CC3)C2 C[C@]1(CNC(=O)CN2CCC(F)CC2)CN(C(=O)C3CC4(CC(O)C4)C3)CCO1 CC1=NSC(N)=C1C(=O)N2CCC(C)(CNC(=O)[C@@H1]3C[C@H1]3C4=CC=NC=C4)CC2 O=C([C@@H1]1C[C@H1](O)CN1CC2=NC=CS2)N3CC[C@H1](CO)[C@H1](O)C3 CCC1(C(=O)NNC2=CC=NC(Cl)=C2)CC(C)(C)C1 CC=1C=CN(C[C@@H1](C)C(=O)NC2CN(C(=O)[C@@H1]3COC4=CC=C(Cl)C=C43)C2)N=1 CC1=CC(C(=O)N2CC(O)(CNC(=O)[C@@H1]3CCCN3C(N)=O)C2)=C(C)N1C4CC4 CS(=O)(=O)SCC(=O)N[C@@H1]1CCN(C2=NC3=CC(Br)=CC=C3O2)CC14CCC4 O=C(CSCC1=NC=C[NH1]1)NC[C@H1]2CN(C(=O)CCN3C=CC=N3)[C@H1]4CCN2C4 C[C@@H1](NC(=O)C[C@@H1]1CN2C=CN=C2NC1=O)[C@@H1](CO)NC(=O)C3(S(C)(=O)=O)CC3 O=C(N[C@@H1]1C[C@H1]2CN(C3=CC=C(C(F)(F)F)C=N3)C[C@H1]21)C4=CC=C5C(=N4)CCC5 CNS(=O)(=O)CCC(=O)N[C@H1]1CN(C(=O)C=2C=CC3=NC(C)=NN3C=2)C[C@@H1]1C CC1=CC(C(=O)N2CC=C(C(=O)NC3CC(C4CC4)C3)C2)=CC(C)=N1 O=C(CNC(=O)C1CC1)NC2CC(C3CN(C(=O)CC4=CC=CC=C4O)C3)C2 O=C(NC1=CC=CC(Cl)=C1I)[C@@H1]2CN(CC3=C[NH1]C4=NC=C(Br)N=C34)CCS2 CC=1C=C(C(=O)NC[C@H1]2C[C@@H1](CNC(=O)CS(=O)(=O)CCO)CO2)OC=1C CC(C)C[C@@H1](C)CC(=O)N(C)C[C@@H1](C)CNC(=O)C1=CC=CC2=NC=CN12 CCOCCN1N=C([C@@H1](OC)C2CC2)N=C1C3=CC=CC=4C=CSC3=4 C#CCC[C@@H1]1CCCN1C(=O)[C@@H1](NC(=O)[C@@H1]2C[C@H1](F)CN2C)C3CC3 O=C([C@@H1]1CCCC[C@@H1]1F)N2C[C@@H1]3C[C@H1](C2)C3NC4=CC(O)=NC(=O)N4C5CC5 CCN1C=C([C@@H1]2OCCC[C@H1]2C(=O)NC[C@@H1]3CCN3C(=O)[C@H1](C)CF)C=N1 C[C@@]12CC[C@@](CC(=O)N[C@@H1]3C[C@@H1]4C[C@H1](NC(=O)C5=COC=N5)[C@H1]3C4)(CO1)C2 CN1C(=O)CC[C@H1]1C(=O)NCCCOCCNC(=O)C(=O)NC2=CC=C(Cl)C=C2 CC(=O)C1=CC=C(C(=O)NCCN[C@@H1]2CCN(C(=O)C3(CC(F)F)CC3)C2)O1 CCN1N=CN=C1C(=O)NC[C@@H1](C)CNC(=O)C2=CC=C3C(=C2N)CCCC3 CCC[C@H1](OC)C(=O)N1CCC[C@H1]1C2(NC(=O)[C@@H1](CC(C)C)OC)CC2 C[C@@H1](F)CC(=O)N1C[C@H1]2CCO[C@@]2(CNC(=O)CN(C)C3=CC=CC=C3)C1 CCC1=CC=C([C@@H1](C)N[C@H1]2CCN(C3=CC=CC=C3C(N)=O)C2)O1 CC(C)[C@H1](CNC(=O)[C@H1]1CCN(C)C(=O)C1)NC(=O)C[C@H1](C)CC(C)(C)C COC1=CC=C(CN2C=C(CCC3(O)CN(C(=O)C4=CC=C(Br)C=N4)C3)N=N2)N=N1 COC[C@H1](OC)C(=O)N[C@@H1]1CN(C(=O)C23CCC(N=[N+1]=[N-1])(CC2)C3)CC4(CC4)C1 C[C@@H1](C(=O)NC[C@@]1(NC(=O)C=2N=NN(C)C=2N)CCOC1)N3C=NC=N3 C[C@H1]1CCC=2C(C(=O)N(CCNC(=O)[C@H1](C)C(C)(F)F)C3CCCC3)=CSC=2C1 CC1=CCS[C@@H1]1C(=O)N2CCC[C@](CO)(NC(=O)C=3C=COC=3)C2 CC=C[C@H1](O)C(=O)NC[C@H1]1CCCN(C(=O)C=2SC=C(Br)C=2C)CC1 CCC=1N=COC=1C(=O)N[C@@H1]2CN(C(=O)C3=CC(C)=C(CC)O3)C[C@H1]2O O=C(NCC1=C(CCNC(=O)C2COCCOC2)OC=N1)C3=CC=NC(S)=C3 C[C@@H1](NC(=O)C1=CC=C(I)C=C1)C(=O)NC2(C(=O)O)C[C@@H1]3CC[C@H1]2C3 CCC(C)(C)CC(=O)N1CC(N2C=C(CNC(=O)[C@]3(C)CC[C@H1](C)C3)N=N2)C1 CSCC12CC(C(=O)N[C@@]34CCC[C@H1]3N(C(=O)C=5C(C)=NSC=5C)CC4)(CO1)C2 O=C(NCCC1CC1)[C@@H1]2[C@H1](C3CC3)CCN2C(=O)COC[C@H1]4CCCO4 CC(C)[C@@H1]1C[C@H1]1C(=O)NC[C@H1](C(=O)N2CC[C@H1](C3=CC=CO3)C2)C(C)C CC1CCN(CC(=O)N[C@@H1]2CC[C@@](C)(CNC(=O)CCOCC(F)(F)F)C2)CC1 CCC[C@@H1](C)C(=O)N[C@@H1]1C[C@@H1]2CC[C@H1](C1)N2C(=O)[C@H1](C)CSC(F)(F)F CC1=CC=CC(C[C@@H1](NS(=O)(=O)CC2(C#N)CCOCC2)C3=CC=CC=N3)=C1 CCCC=1N=NSC=1C(=O)N2CCC3(CC2)CN(C(=O)C4=CC=C(Cl)C=C4)C3 CC1=CN2C=CC(C(=O)N3CC(O)(CN(C)C(=O)C4=NC=CN4C)C3)=CC2=N1 CCN(CC(=O)N1C[C@@H1]2C[C@H1]1[C@H1](N(C)C(=O)[C@@H1](C)NC(=O)CC(C)(C)C)C2)C3CC3 NC1=CC=CC(C(=O)N[C@H1]2C[C@@H1]2NC(=O)C3=CN=C(S)[NH1]3)=C1N CC1(C)C[C@H1](NC(=O)C(N)=O)CN1C(=O)CC=2C=CN(C(F)F)N=2 CC1=CC=C(F)C(CN(C)C(=O)C2=CC(C)=CC=C2NC(=O)C(F)(F)F)=C1Cl O=C(N[C@H1]1CCCC[C@]12CCN(C(=O)C3=COCC3)C2)C4=C(Cl)C=CC(F)=C4F C=CC[C@H1](CNC(=O)[C@]1(CC2=CC=C(F)C=C2)CCCO1)C[C@H1](C)C(C)(C)C CC(=CC1=CC=NC=C1)C(=O)N[C@H1]2COC[C@H1]2N3C=C([C@H1]4CCCC(=O)C4)N=N3 C[C@@H1]1C[C@@]1(C#N)C(=O)N2CCC[C@H1](CCC(=O)N3CC(CC4CC4)C3)C2 COC=1SC=CC=1C(=O)N[C@@]2(C)CCCC[C@H1]2C(=O)NCC=3N=N[NH1]N=3 CCN1CCC[C@H1](NC(=O)C(=O)NC[C@@H1]2CCOC(C)(C)C2)C1 C[C@@H1](CN(C)C(=O)CC=1C=CC2=C[NH1]N=C2C=1)NC(=O)[C@@](C)(O)C(F)(F)F CC(C)[C@H1](CNC(=O)CN1C=NN=N1)C(=O)NOCC2CCCC2 CC1=CC=C(C)C(C(=O)N[C@H1]2CCC[C@@H1]2CNC(=O)C3(S(C)(=O)=O)CCC3)=C1 CCC=1C=C(C(=O)N[C@@H1]2CCC[C@@H1](CNC(=O)C(C)(C)COC(C)C)C2)N(C)N=1 C=C(C)C[C@H1](NC(=O)CCN1C=CC=C1)C(=O)NC[C@H1]2COCC2(C)C BrC1=CC(I)=CC=C1CN2CCCOCC2 O=C(NCCC1(O)CN(C(=O)C2=CC=C3OC(=O)OC3=C2)C1)C4=CC=NC(O)=C4 COCC[C@H1](OC)C(=O)N[C@H1](C(=O)NCC(=O)N1CCCO1)C2CC2 CC1=NN(C)C=C1C2=CC(CN[C@@H1](C)C3=NC=CC=N3)=CC=4[NH1]C=CC2=4 C#CC1(N(C)C)CN(C(=O)C(=O)NC[C@H1](C2=CC=CC(C(F)(F)F)=C2)N(C)C)C1 CC=1C=C(C(=O)NC[C@@H1]2CC3(CC3)CN2C4=NC(C5CC5)=NC6=CC=CC=C46)ON=1 CCC[C@@H1](CC)C(=O)N1CC(NC(=O)[C@@H1]2CN(C(=O)OC(C)(C)C)[C@@H1]3C[C@@H1]23)CC1 O=C(C[C@@H1]1CN(C(=O)C2=CC=CC(F)=C2O)CCO1)NC3=CN=C(Cl)C=N3 CC(C)(CNC(=O)C1=CCOCC1)CC(=O)N2CC[C@H1]3CC[C@@H1](C2)N3C CCCC[C@@H1](NC(=O)C[C@@H1]1CCCCO1)C(=O)NCCSCC CCN1C(=O)CC[C@H1]1C(=O)NC[C@@H1]2CC3(CCC3)CN2C(=O)C4=CC(Cl)=NN4C CC(C)CC(C)(C)CNC(=O)[C@H1]1OCC[C@H1]1NC(=O)C2=C[C@H1]3C=C[C@H1]2C3 C[C@H1](NC(=O)C[C@@H1]1CCC[C@H1]1O)C2(O)CN(C(=O)C3=CC=CN4C=NN=C34)C2 C=C(Cl)CONC(=O)CC1=CCN(C(=O)C(C)(C)[C@@H1](O)C(C)C)CC1 CC1=CC=NN1CC(=O)NC[C@@]23CCCC[C@@H1]2CN(C(=O)C4=CC(C#N)=C[NH1]4)C3 COC1=C(C)N=C(N(C)C)[NH1]C1=NCC2=NC=CN2C COCC1(C(=O)N[C@@H1](C)[C@H1]2CCN(C3=C(C)C=CC=C3[N+1](=O)[O-1])C2)CC1 CC[C@H1](NC(=O)[C@@H1](C)C1CCN(C(=O)COC(C)CC)CC1)[C@@H1]2CCCCO2 C[C@H1](O)CN(CCF)C(=O)[C@H1]1C[C@@H1](C)N1C(=O)C2=CCCCCC2 CC[C@@H1](CN(C)C)C(=O)N1CC[C@H1]2[C@@H1](C1)[C@@H1]2C(=O)N3CCN(CCO)[C@H1](C)C3 CC1=CC=C(CC(=O)N2C[C@H1](N(C)C(=O)C3=CN4C=CC=NC4=N3)C(C)(C)C2)O1 CCCCC[C@@H1](O)CC(=O)N[C@H1]1CCCC[C@H1]1CNC(=O)CCCC(=O)N(C)C COC=1C=C(C(=O)N2CCCCC3(C2)CN(C(=O)[C@@H1]4C[C@@H1]4CF)C3)SC=1Cl CC#CC[C@@H1](NC(=O)CC1=C(C)C=NN1C)C(=O)N2CC3=CC=NN3C[C@H1]2C CC[C@H1]1CN(C(=O)C2(F)CCCCC2)CC[C@H1]1CNC(=O)C3=NC=C(C)C=C3F CCC1=NC(C(=O)N2CC[C@H1](N(CC3CC3)C(=O)[C@H1](OC)C(C)C)C2)=C(N)[NH1]1 COC[C@@](C)(OC)C(=O)NC[C@H1](C)NC(=O)CC=1N=C(C2=CC=CS2)OC=1C CC1(C)COCCN(C(=O)[C@H1](CC2=CN=C[NH1]2)NC(=O)COC3CCCC3)C1 CCC=1C=NSC=1C(=O)NC[C@]2(CNC(=O)[C@]3(C)CCCC3(F)F)CC2(F)F CCC=CC(=O)N1C[C@H1](O)C[C@H1]1CNC(=O)C2=CN=CC(OC3CCC3)=C2 O=C(CNC1=CC=C(F)C=C1)N2C[C@H1]3C[C@H1](NC(=O)C4CC(CF)C4)C[C@H1]2C3 C[C@H1](CC1CCN(C(=O)C2=CC(CN(C)C)=C[NH1]2)CC1)NC(=O)C=3C=NN(C)C=3 CC[C@@H1](CC(=O)NCCCCN1C=C([C@@H1](C2CC2)N3CCOCC3)N=N1)C(C)C C=CCC(F)(F)C(=O)N1CCC(CCN(C)C(=O)[C@]23CCC[C@H1]2C3)CC1 CC1=NC=CN=C1C(=O)N[C@H1]2C[C@H1]3CC[C@H1]2CN3C(=O)C4=N[NH1]C=C4C(C)C CC(C)=CCC(=O)NCC1=CN(CCNC(=O)C2=CC(C)=C(C(F)F)C=N2)N=N1 CCC[C@@H1](CC)C(=O)N1CCCN(C(=O)C=2C=CC3=NN=C(O)N3C=2)[C@H1](CO)C1 C=CC1=CC=C(C(=O)N(C)[C@H1](C)CNC(=O)[C@@H1](C)OCCCC)C=C1 CN(CC1=CC=CN1C)C2=NC=NC3=C2N=CN3[C@H1]4CCC(C)(C)NC4=O CN(C[C@@H1]1CCN(C(=O)[C@H1]2C[C@H1](CF)C2)C1)C(=O)[C@H1]3CCC4=CC=CC(=O)N43 CCN(CCN(CC)C(=O)[C@@]12CC[C@H1]1C2)C(=O)C3=NN4CCCN=C4N3 C=CC=C(C)C(=O)N[C@H1](C)/C=C/C(=O)N[C@H1](C)CC1=CC=CN=C1 CCCCSCCC(=O)N1C[C@@H1](C)[C@@H1](NC(=O)[C@@H1](C)C=2C=NN(C)C=2)C1 CCCC[C@@H1](CNC(=O)C1=CC=C(OC)C=C1Cl)NC(=O)CSC CCC1(NC(=O)[C@H1](CC(C)(C)C)NC(=O)[C@H1]2C[C@@H1](O)C2)CCCC1 C#CC1(C(=O)N2CCC([C@H1](F)CNC(=O)COC(F)(F)F)CC2)CC1 CSC1=CC(C)=C(C(=O)N2CC(CCNC(=O)/C=C/C(C)C)C2)S1 CCCC[C@H1](C(=O)NCC[C@H1](O)C(=O)N(CC)[C@H1](C)CO)C(C)C CCC1=NC(C(=O)N2C[C@@H1](NC(=O)C3=NO[C@@H1](C)C3)[C@H1](C(F)(F)F)C2)=CO1 C#CC1=CC=C(C(=O)N[C@@H1](C)CN(CC)C(=O)C2=CC([N+1](=O)[O-1])=C[NH1]2)C=C1C CCN(C(=O)C1=CN=CC(OC)=N1)[C@@H1](C)CNC(=O)C[C@H1](C)C2=CC=CC=C2F COC1=CC=C(C(=O)N2C[C@H1](O)C[C@H1]2CNC(=O)[C@H1]3CCCN3S(C)(=O)=O)C=N1 NC(=O)CC1(NC(=O)[C@H1]2C[C@@H1]2C3=CC=C(C(F)F)C=C3)CCC1 CCCOCCCC(=O)N1CC[C@@]1(C)CC(=O)N(CC(F)F)CC2CC2 CSCCC(=O)N(C)[C@H1]1CC[C@H1](NC(=O)C2=CC(Cl)=C(N)C([N+1](=O)[O-1])=C2)C1 CC1=CC=C2C(=C1)[C@H1](C(=O)N3CC[C@H1](NC(=O)[C@H1](C)N4CCC4)[C@@H1](F)C3)OCC2 C=C=CCC(=O)N1CCC[C@]2(C1)CN(C(=O)CC3=CC=CC(C)=C3Br)CCO2 CCCCCN(CC)CCC(=O)N[C@H1]1CCN(C(=O)CCCC2CCCC2)[C@H1]1C CC[C@@H1](C(=O)OC)N(C)C(=O)[C@H1]1CCN(C(=O)[C@@H1]2CCCO[C@@H1]2C)CC1(C)C C#C[C@]1(C(=O)NC2=CC=C(Cl)C=C2)CCN(C(=O)C(=O)C(C)(C)CC)C1 CC(C)CCCOCC(=O)N[C@@H1]1C[C@H1]2[C@@H1]1CCN2C(=O)[C@H1]3CCNC3=O C[C@@H1]1COC[C@@H1](CNC(=O)[C@]23CO[C@H1](C2)[C@H1](NC(=O)CCOC4CC4)C3)O1 CCNC(=O)CCC(=O)NC[C@@]1(C)CN(C(=O)[C@]23C[C@H1]2COC3(C)C)CCO1 C=CCC1(NC(=O)C2=CC(F)=C(C)C=C2Cl)CN(C(=O)[C@@]3(COC)C=CCC3)C1 CC1=CC(F)=C(N)C(C(=O)N2CC[C@@]3(CCCN(C(=O)CSC(F)(F)F)C3)C2)=C1 COCCCCN(C)C(=O)C12[C@H1]3CC(C[C@H1]31)[C@H1]2NC(=O)[C@H1]4CC5=NC=CN5C4 C[C@H1](C[C@@H1](C)NC(=O)CCC=1C=CC(=N)[NH1]C=1)NC(=O)CC2=C(F)C=CC=C2Cl C[C@@H1]1CN(C(=O)C=CC(N)=O)CC[C@H1]1NC(=O)C(F)=CC(C)(C)C CC1=CC=C([C@H1](F)C(=O)N2CCC[C@H1](CCNC(=O)C(=O)C3CCCC3)C2)C=C1 CC1=NC=C(C(=O)N(C)[C@H1]2CCCN(C(=O)C3=CCCC[C@H1]3C)CC2)S1 CN1N=NC2=C(C(=O)N[C@H1]3CCN(C(=O)[C@H1]4COC(=O)N4)C3)C=CN=C21 CC1=CC(Cl)=CC(C)=C1C(=O)N[C@@H1](CNC(=O)[C@H1](O)C(C)(C)C)C2CCC2 CC1=CC(C(=O)N2CCN(C)C[C@H1]2CNC(=O)COCP(C)(C)=O)=CN1C(C)C CC1=CC=NC(C(=O)N[C@@H1]2C=CCN(C(=O)C[C@H1]3CCC[C@@H1]3C)C2)=C1F C#CC[C@]1(C(=O)NC2=CC=CC(C3=NOC(C(F)F)=N3)=C2)CCCO1 CSC[C@@](C)(NC(=O)COC1(C)CCC1)C(=O)NCC2=CN=C(C)O2 CC(=O)N1CCCC[C@H1](NC(=O)C2=CC3=CC=C(Cl)C(F)=C3O2)C1 COC(=O)CC1(C(=O)N[C@@H1]2CCC[C@H1]3CN(C(=O)CC4(O)CCC4)C[C@H1]32)CC1 COC[C@]1(C(=O)N[C@H1]2CC[C@H1](CNC(=O)C3=CC=CN=C3)C2)CCOC1 CC1=CC=C(CCC(=O)N[C@@]2(C)CCN(C(=O)[C@@H1]3CCCN3C(N)=O)C2)S1 CC1=CC=C2OC=C(C(=O)N(C)CC(C)(C)CNC(=O)[C@]3(C)CCCO3)C2=C1 CC1=CC(O)=CC(CNC(=O)[C@H1](CC(F)F)N(C)C(=O)[C@@H1]2C[C@@H1]3CC[C@@H1]3C2)=C1 CC(C)[C@@H1](CNC(=O)[C@H1]1CCCCCS1(=O)=O)NC(=O)C2=CC=C(C3CC3)S2 CCN(CCN(CC)C(=O)C=1C=C2N(N=1)CCCO2)C(=O)C=CBr COC[C@@H1](C(=O)NCC1(CNC(=O)CCC(C)(C)F)C[C@@H1]2CCC[C@H1]2C1)N(C)C CCSCCCN1N=NN=C1[C@H1](NCCN2CCCC2=O)C3=CN=CO3 CC=1C=CSC=1C2=CC=C(C(=O)N3CC[C@@H1](NC(=O)C4=N[NH1]C=C4Cl)C3)S2 C=C[C@@H1](C)CC(=O)NC[C@]1(O)CCN(C(=O)C2=CC=C(N(C)C)C=C2F)C1 N#CC1=CC=C(C(=O)N[C@@H1](CC2=CN(C3=CC=CC=C3Cl)N=N2)C(=O)O)S1 CC1(C(=O)NCCC(=O)N2CC[C@@H1]3OCCC[C@@H1]3C2)CCCCCC1 CC=1C=CN2C(C(=O)N3CCC(CNC(=O)C4=CC(F)=C[NH1]4)CC3)=CN=C2C=1C CSC1=CC=CC=C1C(=O)N2[C@H1]3CC[C@H1]2CN(C(=O)[C@@H1](C)CC4CCC4)C3 C=CCN=C(NCCC1=CC(C)=CC(C)=C1)N2CCC[C@@H1](OC3CCC3)C2 CC(C)NC(=NCCN1CCN(C2=CC=CC=C2)CC1)NCC3=CN=CO3 COCC(C)=CC(=O)NC[C@@H1](C)[C@@H1](F)C(=O)N[C@H1]1CCN2N=CC=C2C1 CCC1(NC(=O)CCC[C@@H1](C)O)CCN(C(=O)CC[C@@H1](C)OC)CC1 CN1C=NC=C1[C@@H1](O)C(=O)N2CCCC[C@H1](NC(=O)C#CC3(C(F)(F)F)CC3)C2 CC[C@]1(C)CC[C@@H1](C(=O)NC[C@@H1]2C3=CC=CC=C3CCN2CCC(F)(F)F)O1 CCN(CCNC(=O)[C@@H1]1CCC[C@@H1]1SC)C(=O)C2=CC(C)(C)C2 CCN(C[C@@H1](C)NC(=O)C1=CC=C2C(=C1)COCC2)C(=O)C3=CN=C(O)C(Br)=C3 COC[C@@]1(C(=O)N2CC[C@H1](NC(=O)CN3C=CC(C4CC4)=N3)C2)CCC(=O)N1 CN1N=C2C(=C1C(=O)N3CCS[C@H1](C(=O)NC4=CC(Br)=CN=C4Cl)C3)CCC2 CN1C=C(CC(=O)NC2(CC3=CC=C(Br)C=C3)CCCCCC2)C4=CC=CC=C41 COC1=CN=C(C(=O)N[C@H1](CC=2C=N[NH1]C=2)C(=O)N[C@@H1](C)CN(C)C)C=N1 C=C(CCNC(=O)CSCC(=O)C1=CC=CC=C1)CNC(=O)[C@@H1]2CCC[C@H1]2CF C#CC[C@@](C)(NC(=O)CNC1=NC=CC=N1)C(=O)NC2(C)CC3(CC3)C2 COC(=O)NCC(=S)N[C@@H1]1CCC2=NC(C3=CC=CC=C3C)=CN2C1 O=C(N[C@@H1]1CCCC[C@@H1]1NC(=O)[C@@H1]2[C@H1]3CCCO[C@H1]32)C4=CC=C([N+1](=O)[O-1])C(Cl)=C4 COC(=O)C1=CC=C(C(=O)NC[C@H1]2CCCCN(C(=O)CC=C(Cl)Cl)C2)C=C1C COC1=NC=C(F)C=C1C(=O)N[C@@H1](C)[C@@H1]2CCCN(C(=O)C3=C(C#N)CCC3)C2 CC[C@H1](C(=O)N[C@@H1]1CC[C@H1]2C[C@H1]1CN2C(=O)C3=CC=CC([S@](C)=O)=C3)[C@@H1](C)O CN1CCN(C(=O)CC=2C=C(C3CC3)ON=2)[C@@H1](CNC(=O)CC(C)(C)C(F)F)C1 CC(=O)NCCNC(=O)[C@H1]1[C@@H1]2C[C@@H1]1N(C(=O)C3=CC4=CC=C(Cl)C=C4S3)C2 CC(C)(O)C#CC(=O)NCC1CN(C(=O)CCC2=CC3=CC=CC=C3[NH1]2)C1 CC(C)C[C@@H1](CNC(=O)C[C@H1](C)N(C)C)C(=O)NCCOC1=NC=CC=N1 COC1=CN=C(C(=O)N(CCN(C)C(=O)C2(C#N)CC(C)C2)C(C)C)N=C1 CC[C@H1](C)C(=O)N[C@@]C1[C@H1]2C[C@@H1](C[C@H1]2C(=O)OC)C1 C[C@H1](CCCCNC(=O)C=C1C2CC3CC(C2)CC1C3)NC(=O)[C@H1]4CCC(=O)N4 COC1(OC)CC[C@@H1](CN2N=NN=C2N3CC[C@H1](C4(C)CC4)C3)C1 CC1=CC(NCCOC2CC2)=NC=C1S(=O)(=O)N3CC[C@@H1]([C@@H1]4CCCO4)C3 CCC(CC)(CCNC(=O)C1=COC2=CC=C(F)C=C12)NC(=O)[C@H1](C)SC(C)C COCCC[C@H1](C)C(=O)NC1(CNC(=O)C=2SC=NC=2C)CCOCC1 COC1=NC=CC(C)=C1NC(=O)C[C@@]23CC[C@H1]2CN(C(=O)CCCNC(N)=O)C3 CC1=CC(C(=O)N2CC[C@H1]([C@@H1](C)NC(=O)[C@@H1](C)C3=CC=C(C#N)C=C3)C2)=CC=N1 CO[C@@]1(CNC(=O)[C@@H1](F)CC(C)(C)C)CCN(C(=O)[C@H1]2CCC[C@@H1]2C(C)C)C1 CC=1C=NN(CCC(=O)NC[C@H1](C(=O)N(C)C[C@H1](O)C(C)(C)C)C(C)(C)C)C=1 C=CCC1(C(=O)NN2CCC[C@H1]2C(=O)NCCCC3=CC=CC=C3)CCCC1 N=C1C=C[NH1]C(C(=O)NC[C@H1](NC(=O)[C@@H1]2CCOC2)C3CCCCC3)=N1 CN(CC(=O)NCC1=CC=NC=C1)[C@@H1]2CCCN(C(=O)C3(CO)CC3)C2 CO[C@H1]1CCN(C(=O)[C@H1]2CCCCN2C(=O)C3=CC=CC(S(N)(=O)=O)=C3)C1 CC1=CC=CC(Br)=C1[C@H1](NC(=O)[C@H1]2CC23CCCCC3)C(=O)O CC=1SC(Br)=NC=1CN[C@H1]2CCS[C@@H1](C3=CC=CN=C3)C2 CC=1C=C(C(=O)N[C@H1](CCNC(=O)CN2N=C(C)C(C)=C2C)C(C)C)[NH1]C=1C CC1=CC(Cl)=CC=C1N2C=C([C@@H1]3CCN3C(=O)C[C@@H1]4CN(C)C[C@H1]4O)N=N2 CC1=CC(Br)=CC=C1C(=O)NCC2CCN(C(=O)[C@H1]3CC[C@H1]3C)CC2 CCC1=CC=C(NC(=O)C=2C=CN(CCNC(=O)C#CC3CCOCC3)C=2)C=C1 CN1C(=O)C(=O)N(CC(=O)NC[C@H1]2[C@@H1]3CN(C(=O)COCC4(F)CC4)C[C@H1]23)C1=O CCC=1C(C(=O)NCCNC(=O)CN(C)C(=O)C2=CC=CN2C)=CSC=1C COC=1SC=CC=1C(=O)N[C@H1](C)[C@H1]2CCCN2C(=O)[C@@H1]3CCCSC3 O=C(N[C@@H1]1C[C@H1](C(=O)NC2C[C@@H1]3C[C@H1]3C2)C14CCC4)C5=CSC=C5Cl CC(C)CO[C@H1](C)C(=O)NC1CCC(N(C)C(=O)[C@H1]2CCCO[C@H1]2C)CC1 CC(C)[C@H1](O)[C@H1](C)NC(=O)C1=CC=C(CNC(=O)CN(C)C2CCC2)N=C1 C=C(C)COCC(=O)N[C@@H1](CNC(=O)[C@H1](C)OCCCCCC)C1CCC1 CC[C@@H1]1CCC[C@]1(C)C(=O)NCC2(C)CCN(C(=O)[C@H1](C)OC(C)(C)C)CC2 CCC[C@@H1]1C[C@H1]1C(=O)N2C[C@@H1]3C[C@H1](NC(=O)C4=CC=C(C)N4C)C[C@@H1](C3)C2 CCS(=O)(=O)N[C@H1](C)C(=O)N1CCCC[C@@H1]1CNC(=O)[C@H1](CC(C)C)C(N)=O CC1=CC(C)=C(C(=O)N2CCC[C@@H1](NC(=O)CCN(C)CC(F)(F)F)[C@H1]2C)O1 CC=CC=CC(=O)NCCC1CN(C(=O)CC(C)(C)CCC)CCC1 O=C(N=C1C=CN=C(Br)[NH1]1)[C@@]2(F)CCN(C3=NC=NC=C3I)C2 CC(=O)N(C)[C@@H1](C)C(=O)N[C@H1]1C[C@@](C)(NC(=O)CCNC(=O)CO)C1 O=C(NC1CC1)[C@@H1]2CCN(C(=O)N=CC3=C[NH1][C@H1]4C=C[C@@H1]3C4)C2 COC1=CC(N(C)C)=CC=C1C(=O)NC[C@](C)(NC(=O)C2=NOC=C2C)C(C)C CCN(CC(C)(C)CNC(=O)C(F)(F)CC1CC1)C(=O)[C@H1]2CCCC=3N=C[NH1]C=32 C[C@@H1]1CC[C@H1](C(=O)N2CCO[C@H1]([C@@H1]3CCOC3)C2)O1 COC1=CC(C(=O)N2CCC[C@@H1](CN=C3[NH1]C4=NC=C(Cl)C=C4S3)C2)=CC=N1 CCN1CCC[C@@H1]1C(=O)NC[C@H1](C)N(CC)C(=O)C2=NN(C(F)F)C=C2Cl C#C[C@H1](CNC(=O)C1=CN(CCNC(=O)C2=CC=CN2C(C)C)N=N1)OC CC[C@]1(N(C)C)CCN(C(=O)[C@H1]2C[C@@H1](NC(=O)C3=CSC(O)=N3)CCO2)C1 CC1(C)[C@H1]2CC[C@@H1](C2)[C@@H1]1C(=O)N[C@@H1]3C[C@@]4(NC(=O)C5=CC=CC=C5Cl)CO[C@@H1]3C4 CC1(C)COC[C@@H1]1C(=O)N2CC[C@H1](O)[C@H1](N(C)C(=O)[C@@H1]3CC4=NC=CN4C3)C2 C=C[C@@](C)(CC)NC(=O)CN(C(=O)[C@@H1](C)C(C)C)C1CCC1 CN1C=C(CN2CCC[C@@H1](C(=O)N3CC4(CCOC4)C3)C2)N=C1Cl CO[C@H1](C)C(=O)N(C)[C@@H1](C)CCNC(=O)C1=CN=C2C=CC=CC2=C1 CCCCC1(C(=O)N[C@@H1](C)CNC(=O)C2=C[NH1]C=C(Br)C2=N)CCCC1 CO[C@H1](C(=O)N1CC[C@H1](NC(=O)[C@H1]2CC3=CC=CC=C3O2)C[C@H1]1)C4CCCCC4 CCOC1=CC=C(CC(=O)N2CC(CNC(=O)C3=CC=C4OC=NC4=C3)C2)C=C1 CC=1SC(C(=O)N2CCCC(C)(C)[C@@H1]2CNC(=O)C3CC(C#N)(OC)C3)=NC=1O O=C(C1=CN=C(Cl)S1)N2CCC[C@]3(C2)CN(C(=O)[C@@H1]4CC(=O)C45CCC5)CCO3 CCC1=CC(CC)=NC(N(C)[C@@H1](C)CNC(=O)C[C@H1](C)C2=CC=C(F)C=C2F)=N1 CC1=CC=CC(C)=C1C(=O)N2CCC(NC(=O)[C@@H1]3CC[C@@H1]3F)CC2 CCC1=CC(C(=O)N2CC[C@H1]([C@H1](F)C(=O)NCC3=CC=CC(O)=C3F)C2)=NN1C CC(C)(CNC(=O)C1=CC(Cl)=CN=C1O)CN2C=C(CNS(=O)(=O)C3CC3)N=N2 CNC(=O)NCCC(=O)N1CC[C@@H1](C)[C@@H1](NC(=O)C2=COCCO2)C1 CC(=O)NCCCC(=O)N1CCN(C(=O)C2CC3=CSC=C3C2)C[C@@H1]1C CCO[C@@H1](C(=O)N[C@H1]1C=CCN(C(=O)C2=CC(C(F)(F)F)=NO2)C1)C3CCC3 CNC(=O)NCCC(=O)N1CCC(N(C)C(=O)CNC(=O)C=2C=CSC=2)CC1 O=C(CCCCCNC(=O)CN1C(=O)CCCC1=O)NC[C@H1]2CCCC[C@H1](O)C2 CC(F)(F)C1=CC(C(=O)N2CCC3(CC(NC(=O)C=CC4CC4)C3)C2)=CC=N1 CO[C@@H1]1CN2CCC[C@@]2(C(=O)N3CC4(CN(C(=O)CSCC5=CSC=N5)C4)C3)C1 COC(=O)C1=NO[C@@]2(CCN(N(C)CCOC3(C)CCCC3)C2)C1 O=C(NCC1=CC=CC=N1)C(=O)NCC2=CC=CC(CN3CCCS3(=O)=O)=C2 O=C(NC[C@]12C[C@H1]1CN(C(=O)CCCOC3=CC=CN=C3)C2)[C@H1]4C=CCCC4 CC1=CC(C(C)C)=NC(=NC[C@H1]2CCC[C@H1]2NC(=O)C3=CC(C(N)=O)=C[NH1]3)[NH1]1 CCOCCC(=O)N1C[C@@H1](NC(=O)C=2SC(C(C)(C)C)=NC=2C)[C@H1](C(F)(F)F)C1 CCC1(CO)CN(C(=O)C2=CC[C@@H1](NC(=O)[C@@](CC)(CO)OC)C2)C1 CC(C)C1=CC(C(=O)N2CC=C[C@@H1](NC(=O)CS(=O)(=O)C(C)C)C2)=NO1 CC[C@@H1](NC(=O)C=1OC(CNC(=O)CC2CC2)=NC=1C)C3=NC=C(C)[NH1]3 O=C(N[C@H1]1CN(C(=O)C2=CC=C(C(F)(F)F)S2)C[C@H1]1CO)C3=C[NH1]N=C3C4CC4 ClC1=CC(Cl)=CC([C@@H1](NCC2=NOC(C3CC3)=N2)C4=CC=CC=C4CO)=C1 CCC1=NN(C)C(Cl)=C1C(=O)N2C[C@@H1](NC(=O)[C@H1]3CCCN3C4CC4)[C@H1](OC)C2 COCC1(CNC(=O)C(F)(F)C=2C=NN(C)C=2)CN(C(=O)C3=CC=NN=C3O)C1 O=C(N[C@H1](C1=CC=C(Cl)C=C1)C2CC2)C3=CC=C(N4CC=CC4)C=C3 CC(=O)C1=C(Cl)N=CN=C1N2CCC[C@@H1]([C@@H1]3CCCN(C(=O)C=CCF)C3)C2 COC=1C=C(C(=O)N2CC[C@H1](C(=O)NC[C@H1](O)C(F)(F)F)C2(C)C)N(C)N=1 CC[C@@H1]1[C@@H1](NC(=O)C2=C(C)N=CN2C)CCN1C(=O)[C@H1][C@@H1](C[S@](C)(=N)=O)C(C)C C[C@@H1](CN(C)C(=O)[C@@H1]1CCCN1C(=O)C=2C=COC=2)NC(=O)C3=CC=C(F)C=N3 CCC1(NC(=O)C=CC(=O)N(C)C)CN(C(=O)CC2CC(F)(F)C2)C1 CC#CCCCC(=O)N1[C@H1]2CC[C@@H1]1C[C@@H1](CNC(=O)C3(C4=N[NH1]C=C4C)CC3)C2 CC=1SC(=NC[C@](C)(NC(=O)CC(F)(F)C(F)F)C(C)C)[NH1]C=1C2=CC=CC=C2 CS[C@H1](C)C1=CC=CC(N[C@]2(C3=NN=NN3C(C)C)CCCN(C)[C@@H1]2C)=C1 CC[C@]1(NC(=O)[C@@H1]2SCC=C2C)CCCN(C(=O)CCCCCCSC)C1 CCCOCC(=O)N[C@@H1]1C[C@H1]2[C@@H1](C1)[C@@H1]2NC(=O)C=C3CCCCC3 CN(C[C@H1]1CCCN1C(=O)C2=CC=CC=3C=NSC2=3)C(=O)C=C[C@@H1]4CCCO4 CC(=O)OCCC(=O)N[C@]12CCC[C@@]1(F)CN(C(=O)[C@H1](C)CO)C2 CN1CC[C@@H1](C(=O)N[C@H1]2CCC[C@@H1](NC(=O)C(C)(C)C3CCC(O)CC3)C2)C1 CC(C)(C)NC(=O)[C@H1]([C@H1]1C[C@H1]2C=C[C@@H1]1CC2)N3C[C@H1]4C[C@H1](O)[C@H1](O)C[C@H1]4C3 CSCC[C@@H1](C(=O)N[C@@H1]1CN(C(=O)C2=CC=C(C(C)(C)C)S2)C[C@@H1]1F)N(C)C COC[C@@](C)(CCO)NC(=O)[C@@H1]1CN(C(=O)C2=CSN=C2C)CCN1C COCC1(NC(=O)C2CCC2)CN(C(=O)CSC3=NN=C4C=CC=CN34)C1 CC1=CC=C(C(=O)NC(C)(C)/C=C/C(=O)N2CC(OCCF)C2)C=N1 CCCNC(=O)[C@H1](C1=CC=NC(Cl)=C1OC)N2CCC(COC(C)(C)C)CC2 COC1=NC(O)=CC(C(=O)NC[C@H1]2CN(C(=O)C[C@@H1]3C=CCCC3)CCCO2)=N1 CCC1=NO[C@H1](CC(=O)N[C@H1](C)C2=NOC=C2C(=O)N3CC[C@H1]3CO)C1 CN1N=C(CNC(=O)NNC(=O)C2=CC3=CC=CC=C3O2)C4=CC=CC=C41 CC(C)[C@@H1](O)[C@@H1](C)C(=O)N1[C@H1]2CC[C@H1]1CN(C(=O)CC3CCCCCCC3)CC2 CC(C)C(=O)N1CCC[C@H1]([C@H1]2C[C@@H1]2NC(=O)CC3=CC=C(C(C)(C)C)C=C3)C1 C#CC[C@H1](C)C(=O)NC12CCC(CNC(=O)C3=CC(F)=CC=C3N)(CC1)OC2 O=C(CC1=N[NH1]C2=CC(C=3C=NN([C@H1]4CCOC4)C=3)=CC=C12)NC5(CO)CCC5 CC=1[NH1]N=C(C(=O)N[C@H1]2C[C@H1](C(=O)NC3=NC(C(F)(F)F)=CC=C3Cl)C2)C=1C CCCOC1=CC=CC(C(=O)N(C)CCCN(C)C(=O)C2=NOC=C2C(C)C)=C1 O=C([C@H1]1CC1(Cl)Cl)N2CCN(C(=O)C3=CC=4SC=CC=4S3)[C@@H1](CC(F)F)C2 CC(C)[C@H1](C)COC(=O)C1=CC(C2=CC=CC=C2)=COC1=O COC1(CNC(=O)C2=COC(C#N)=C2)CN(C(=O)[C@@H1]3O[C@@H1]4CCCC[C@@H1]4[C@@H1]3C)C1 CCCN=C(NC[C@H1](C1CC1)N(C)C)N2CCC[C@@]3(CCC4=CC=CC=C43)C2 CC[C@H1](C)[C@H1](O)C(=O)NC1CC([C@@H1](C)NC(=O)C2=C[C@@](C)(CC)C2)C1 C#CCN(CC(F)F)C(=O)C[C@@H1](CC(=O)OC(C)(C)C)C(F)(F)F CCCCCC(=O)N1CC[C@](CCOC)(NC(=O)C2=CN3C=C(C)C=CC3=N2)C1 CCC(=O)NC1=CN=CC(C(=O)NC[C@@H1](O)CNC(=O)CC2=CC=CC=C2C)=C1 CC1=CC(Cl)=CC(Cl)=C1NC(=O)[C@H1]2CSCCN2C(=O)C3=CC=C(F)C=C3Br CC(C)[C@@H1](CCNC(=O)[C@@H1]1COC2=CC=C(Cl)C=C2C1)NC(=O)CN3N=CC=N3 CCN1N=C(C(=O)NN2CCC[C@H1]2C(=O)N[C@@H1](C)CCN3C=NC=N3)C=C1C CC1=CC=C(N(CC(C)C)C(=O)CN2C(=O)N[C@](C)(C3=CC=CS3)C2=O)C=C1 CC1=CC=CC=C1N2N=C(C(C)C)N=C2[C@@H1]3CCC4(CCC4)OC3 O=C(CCCC1=CN=CC=N1)N[C@@H1]2C[C@H1]2CNC(=O)C=3[NH1]C=CC=3C4=CC=CS4 CNC(=O)C1=CC=CC(NC(=O)CN2C[C@@H1]3C[C@@]3(C(=O)OC)C2)=C1 CC1=CC(C)=C(C(=O)NCCC2(NC(=O)[C@@H1]3CC[C@H1]3C)CC2)S1 CN(CC1=CC=CN=C1)C(=O)C(C)(C)[C@@H1]2CCCN(C(=O)C3=CN=C(N)C=N3)C2 CN1N=C(Cl)C(C(=O)NC[C@H1](O)CNC(=O)C2=CC=C(C3COC3)C=C2)=C1Cl CC(C)C[C@@H1](F)C(=O)N(C)CCOCCNC(=O)C1=CC=C2C(=C1)CCNC2=O CCC1=CC=CC(C(=O)N2CC[C@H1]3[C@@H1](CCN3CC4=C(O)C=CC=C4O)C2)=C1 CCC[C@@H1](CCCNC(=O)CC1(C)CCC1)NC(=O)CCC(=O)C2=CC=CC=N2 CN(CCN(C)C(=O)[C@H1]1CC[C@H1](C(F)(F)F)CO1)C(=O)C=CC2=CC=C(O)C=C2 CCC=1OC=CC=1C(=O)NC[C@H1]2CCN(C(=O)CCCC(C)C)C[C@@H1]2C CC1=CCS[C@H1]1C(=O)NCCCN(C(=O)C=2N=CSC=2C)C(C)C C=CC[C@H1](CC)C(=O)N1CCN(C(=O)C2=CN(C(C)(C)C)C=N2)[C@H1](CC3CC3)C1 CC1=CC(N2CC[C@](O)([C@H1](C)NC(=O)CCN3N=C(C)C=C3C)C2)=C(C#N)C=N1 C=C1CCC(C(=O)NCC[C@@H1]2CN(C(=O)C3=NC=C(N)N=C3C)C[C@H1]2C)CC1 CNC1=NC=CC=C1C(=O)N2CCC3(CC[C@H1](NC(=O)CS(C)(=O)=O)C3)CC2 C[C@@H1]1CN(C(=O)[C@@]23COC[C@@H1]2C3)C[C@H1]1NC(=O)C4=CC([N+1](=O)[O-1])=C(F)C=C4N COCC1=CC=CC(C(=O)N[C@H1](C)CN(C)C(=O)C2(CSC)CC2)=N1 CCCCC[C@H1](F)C(=O)N[C@H1](C(=O)N[C@H1]1CC[C@H1](O)CC1)[C@@H1](C)OC CC(C)C[C@@](C)(O)C(=O)NC[C@H1](O)CN(C)C(=O)C1C=CC=CC=C1 C#CCC[C@H1](NC(=O)C1=CC[C@H1]2CC[C@H1]1N2C(=O)C[C@H1](C)C(=O)OC)C(=O)OC CP(C)(=O)[C@@H1]1CCCC[C@@H1]1NS(=O)(=O)C=CC=C(NCCO)C2=CN=CC=C2 COC(=O)C1=CC=C2C(=C1)CN(C(=O)N(CC3=NC=CS3)C4CC4)CCC2 COC[C@@H1](C(=O)NCCNC(=O)C1=CC=C(F)C(S(C)(=O)=O)=C1)N(C)C CC[C@@H1](CNC(=O)C1=CC=C(CC(N)=O)C=C1)NC(=O)[C@H1]2C[C@H1](C(F)F)C2 CC1=C(Cl)C=CC(C(=O)N2C[C@H1](F)[C@H1](NC(=O)[C@H1]3CC[C@@H1](C)O3)C2)=C1F CC(C)(C)C1=NC=C(C(=O)N[C@@H1]2COCC[C@@H1]2NC(=O)C(C)(C)CC(F)F)S1 CC(C)(C)[C@H1](CO)C(=O)NC[C@@]1(O)CCN(C(=O)C2=N[NH1]C3=CC=C(F)C=C23)C1 CCCSCC(=O)N1CCN(C(=O)C2CC3(CCC3)C2)C[C@@H1]4CCCC[C@@H1]41 CC1=NNC(=O)[C@H1]1CC(=O)NC[C@]2(F)C[C@H1](NC(=O)CC3(C(F)(F)F)CCC3)C2 COC(=O)C1=CC=C(NC(=O)C2=CC=C(NC(=O)C3=CC=C(Br)C=N3)N=C2)C=N1 O=C(NC1[C@H1]2CC[C@H1]1CN(C(=O)C=C3CN4CCC3CC4)C2)C=5C=CON=5 CC1=CN2C=CC=C(C(=O)N[C@H1](C)[C@H1]3CCN(C(=O)C=4SN=C(C)C=4N)C3)C2=N1 CC(C)(C)CC(=O)N1CC[C@@H1]2CN(C(=O)C3=CC(Cl)=CN=C3O)C[C@@H1]2C1 CCC[C@H1]1CN(C(=O)[C@H1](C)[C@H1](O)[C@H1](C)CC)C[C@@H1]1C(=O)N2C[C@@H1](O)[C@@H1](CO)C2 FC(F)(F)C1=CC=CC(O[C@H1]2CCN(C[C@@H1]3CC[C@H1](C4=CC=CC=C4)O3)C2)=C1 CCN1N=C(C(=O)NC[C@@H1]2C[C@@H1](C)N(C(=O)[C@@H1]3C(F)(F)C34CC4)C2)C=C1C CC=1ON=C(CC(=O)NC[C@H1]2C[C@H1](NC(=O)[C@@H1]3[C@H1]4CCCC[C@H1]43)C2)C=1C#N CC1=CC=C(F)C(C(=O)N[C@H1](C)C[C@H1](C)NC(=O)C2=CC=CC(Cl)=C2)=C1F CCC1=NC=C(C(=O)N[C@H1]2C[C@H1]2NC(=O)C3=C(O)N=C(C4=CC=C(Cl)C=C4)S3)S1 CC1=CN=C(F)C(C(=O)N2CC[C@H1](NC(=O)C3=NN(C(C)(C)C)C=C3Cl)[C@H1]2C)=C1 CNC(=O)C1(C(=O)N(C)CCOCCN(C)C(=O)[C@@H1](F)C(C)(C)O)CCC1 CN(C)[C@@H1](CO)C(=O)NCC1(CNC(=O)COCCO)CC1 CN1C=CC(C(=O)N2CCN(C(=O)C[C@@H1]3CCCOCC3)C[C@H1]2C(F)F)=CC1=O CC(C)(CC(=O)N[C@H1](CO)C1CCN(C(=O)C2=NC=C[NH1]2)CC1)C(F)(F)F COC/C(C)=C/C(=O)N1CC2=CC=CC=C2C[C@@H1]1CNC(=O)CSC(F)F C[C@@H1](CNC(=O)C1=CC(S(C)(=O)=O)=CO1)CNC(=O)[C@H1]2CCC23CCC3 CC(C)[C@H1](C)[C@H1](C)CC(=O)NC1(CNC(=O)CN(C)CC2=CC=CC=C2)CC1 O=C(CCC1OCCO1)N[C@@H1]2CCN(C(=O)C3C[C@@H1]4CC[C@H1](C3)O4)CC25CCC5 O=C(NC1=CC=CC=C1OC(F)F)C2=CSC(CC3=CC=CC=C3F)=N2 CCO[C@@H1](CC)C(=O)N[C@]1(C)C[C@H1](NC(=O)[C@@H1](C)OC2CCCCC2)C1 COC1=CC=CC(COCCNC(=O)CCN2CC3(CCOCC3)C2)=C1 CC1=NN(C)C=C1C2=CC=C(C3=CC=CC(C(=O)N[C@H1](C)C#N)=C3)C(C)=C2F C[C@H1](CCCNC(=O)C#CC1=CC=CC=C1OC(F)(F)F)NC(=O)CC(F)(F)F C#CCN(CC=C)C(=O)[C@@]1(C)CCN(C(=O)C2=CN=CC=C2C)C1 CCC1(C#CC(=O)N2CCO[C@H1](CCCNC(=O)C3=COC(Cl)=N3)C2)CC1 O=C(CNC(=O)C1=CC=CO1)NCCC2CC(NC(=O)CCCCCF)C2 C[C@H1](CNC(=O)C1CC2(CCC2)C1)[C@H1](F)C(=O)N3CC(C)(C#N)C3 COC(=O)[C@@H1]1C[C@@H1]1C(=O)N2CC(N3C[C@H1](NC(=O)C4C5CCC4CC5)CC3=O)C2 O=C(C=CC1CCCC1)NC[C@@]2(F)CC[C@H1](NC(=O)C3=CCOC3)C2 CCCCOCC(=O)N[C@@H1]1C[C@@H1]2CC[C@H1](C1)N2C(=O)[C@H1](SC)C3=CC=CC=C3 C=CCO[C@@H1]1CCN([C@H1](C(=O)NC2=CC=C3C(=C2)OCCO3)[C@H1](C)CC(C)C)C1 CC[C@H1](O)C(=O)N[C@H1](CO)[C@@H1](C)NC(=O)C=1C=C(C2=CC=CC=C2F)ON=1 C[C@@H1](C1=NC=C(Br)C=N1)N(C)S(=O)(=O)CC2(C)CC2 CC=1ON=C(O)C=1C(=O)N[C@H1](C)[C@H1]2CCN(C(=O)C=3C(C)=NN(C(C)C)C=3C)C2 C=CCCC1=CC=C(C(=O)N2CC(NC(=O)C3=COC4=C3COC4)C2)C=C1 O=C(CC[C@@H1]1CC1(Cl)Cl)N2CC3(CCCN(C(=O)[C@H1]4C[C@@]4(F)Cl)C3)C2 O=C(N[C@H1]1CC[C@@H1](OC2=CN=CC=N2)CC1)N3CC(CC(F)(F)F)C3 CCOC(C)(C)C(=O)N[C@H1]1CCC[C@H1](NC(=O)C2=C([N+1](=O)[O-1])C=NN2C)C1 CC=C(CC)C(=O)NC[C@@H1]1CN(C(=O)[C@@H1]2COC(=O)O2)CC(C)(C)C1 CC1=CN=CC(C(=O)N[C@@H1](CNC(=O)[C@H1]2CCC2(C)C)C3=CC=CC=C3OC)=N1 CN1N=NC=C1CC(=O)NC[C@@H1]2CCN2C(=O)C[C@@]3(C)CCCO3 C=CCNC(=O)CNC(=O)C(C)(C)CNC(=O)C1=CC=C(F)C=C1 CNC(=O)N1CC(C(=O)N2CCOCC[C@@H1]2C(=O)N3C[C@H1](C)[C@H1](N=[N+1]=[N-1])C3)C1 CN1C(=O)CSC1=CC(=O)N2CCC3(CCN(C(=O)CNC(=O)C4CC4)C3)CC2 CP(C)(=O)CC(=O)N1[C@H1]2CC[C@@H1]1C[C@@H1](CNC(=O)C3=CN=C(C#N)S3)C2 C=C(C)CCCC(=O)N1CCC[C@H1]1/C=C/C(=O)N2CC[C@@H1](C3=CN=CO3)C2 O=C(N[C@H1]1CCS(=O)(=O)C12CCOCC2)C3=CC=C(F)C=C3Br C#CCNC(C(=O)N1CC[C@H1](NC(=O)C=CC=CCC)[C@@H1](CC)C1)=CC2=CC=CS2 CCC1=CC=CC(C(=O)N[C@H1]2CN(C(=O)CC3=NC=C(F)C=C3F)CC2(C)C)=N1 C#CC1CCN(C(=O)CC[C@H1]2CCCN(C(=O)C3=CC=CN=C3O)C2)CC1 C[C@@H1](CC1=CN=C[NH1]1)C(=O)N[C@@H1](C)C(=O)NCCOCCN(C)C CC(C)(C)C1=CC=C(OCC(=O)NC[C@@H1](CCC(=O)O)C2=CC=C(Cl)C=C2)C=C1 CCC1=NC(C(=O)N[C@H1]2CC[C@H1](NC(=O)[C@@H1]3OCCOC34CCC4)C2)=CO1 C[C@H1]1CN(C(=O)C2(C3=CC=C(F)C(F)=C3)CC2)C[C@H1]1NC4=CC=CC=N4 CC(C)OC1=CC=C(C(=O)NC2(CO)CN(C(=O)C3=C(Cl)CCC3)C2)N=C1 O=C(NCCNC(=O)C1(F)CCOCC1)[C@@H1]2CCN3CC[C@H1]2C3 CN(C)C(=O)C#CC(=O)N1CCN(CCN(C)C(=O)CC=2SC=CC=2Cl)CC1 C=CC=CCC(=O)N[C@@H1]1CCN(C(=O)[C@@H1]2C[C@H1]2C3CC3)C1(C)C O=C1COC2=CC(C(=O)OCC3=NC(O)=CC(C(F)(F)F)=N3)=C(Cl)C=C2N1 NS(=O)(=O)CCC1(C(=O)N[C@@H1]2CCN(C(=O)CN3C=NC=N3)C[C@H1]2F)CCC1 CSC(C)(C)C=CC(=O)N1CC[C@H1](C(=O)NC[C@@H1]2C[C@H1]2Cl)[C@H1]1C CCOC1=NC=C(C(=O)NCC(C)(C)CNC(=O)C=CC2=CC=C(C)C(Cl)=C2)S1 O=C(C[C@H1](O)C1CC1)NC[C@@H1](O)CN=C2C=CC3=C([NH1]2)C(=O)CCC3 CC(C)=CCC(=O)N1CC[C@@]2(CO[C@@H1](CNC(=O)COC3(C)CCOCC3)C2)C1 CC#CCCC(=O)NC[C@@]1(C)CCCN1C(=O)C2=CN(CCCC)N=C2C CSC[C@H1](C)C(=O)N(C)[C@@H1](C)CCNC(=O)C1=CC(C)=C(C(N)=O)C=N1 C[C@@H1]1C[C@H1]1CCC(=O)N2CCC(C3(NC(=O)C4=CC=CC(Cl)=C4)CCCC3)CC2 O=C(NC1=CC=CC(Cl)=N1)[C@@H1]2CCN(CC=3SC=C(Br)C=3Br)C2 CN(C[C@@](C)(O)C1=CC=CC=C1)C(=O)C(=O)N[C@@H1]2CCC3=C(Cl)C=CC=C32 C[C@@H1](C(=O)N1CC(NC(=O)C2=NC=NC(O)=C2F)C1)C3=CC=CC([N+1](=O)[O-1])=C3 CO[C@](C)(CO)C(=O)NCC[C@H1]1CC[C@@H1](NC(=O)C2=CC([N+1](=O)[O-1])=NN2C)C1 CC1=NC(O)=C(C(=O)NCC(C)(C)OCCNC(=O)[C@@H1]2CCS[C@@H1](C)C2)N=C1C CN(C)C1(C(=O)N[C@H1]2C[C@@H1](NC(=O)CSCC3=CC=CN=C3)C2)CCC1 CONC(=O)[C@H1]1CCC[C@H1]1NC(=O)C2=COC(SC)=C2 CO[C@]12CC[C@H1]1CN([C@H1](C(=O)NC3(C)CC3)C4=CC=C(C(C)(C)C#N)C=C4)C2 CCC1=CC([N+1](=O)[O-1])=CC=C1NC[C@@H1](NC(=O)CN2C=C(C)C=N2)C3CC3 C/C=C/C[C@@H1](CC)C(=O)N1C[C@@H1](NC(=O)CC2=CC(C)=NO2)[C@H1](SC)C1 CCCC1=CC(C(=O)NC2(C3CCN(C(=O)CCF)CC3)CC2)=NO1 CN(CCCCC(=O)NCC1=NC(=O)O[NH1]1)C(=O)C=2C=C[NH1]N=2 CC(C)(C#N)CCCC(=O)N[C@H1]1CCCC[C@H1]1N2C=C(C3=NC=CS3)N=N2 CNC=C1C(C(=O)N2C[C@@H1](NC(=O)[C@](CC3=CC=CC=C3)CC(F)(F)F)C[C@@H1](F)C2)=N1 CC[C@@H1](CNC(=O)C[C@H1]1COC(=O)C1)NC(=O)C2=C[NH1]N=C2C3CCC3 CC(C)(C(=O)N[C@@H1]1CC2=CC=CC=C2[C@H1]1NC(=O)C3=CC=NN=C3Cl)C(F)(F)F CC1=CC=C(CCC(=O)NCCCCN(C)C(=O)COCC2=NC=CS2)C(C)=C1 CC[C@@](C)(COC)C(=O)N1C[C@@H1]2CC[C@H1](C1)N2C(=O)C3=COC4=C3CSC4 CCN(C(=O)CN=[N+1]=[N-1])[C@@H1](C)C(=O)NCC1CC(O)C1 CC[C@]1(C(N)=O)CCCN(C2=NC=CC(=NC[C@H1]3C[C@@H1]3C4CCC4)[NH1]2)C1 C[C@H1]1CCCN1CC(=O)N2CCN(C(=O)[C@@H1]3C[C@H1]4C=C[C@@H1]3C4)C[C@H1]2C CCCC1=NC=C(C(=O)N2CC3(CCCCN(C(=O)C4=CC=NC=C4F)C3)C2)S1 CC(C)(CCNC(=O)C1=CC=C(C(F)F)N=C1)NC(=O)[C@@H1]2CC(=O)C23CCC3 CCCN(CCNC(=O)[C@H1]1CC[C@@H1](C)S1)C(=O)CCC2=CC=C(CC(C)C)C=C2 CCCC(=O)N[C@H1](CNC(=O)C=C1C[C@@H1]2CC[C@H1](C1)N2C)C3CCCC3 CC1(C2=CC=CC(F)=C2)CCN(C(=O)C3=CC=NC([C@@H1]4COCCN4)=N3)CC1 C=C(Cl)C[C@H1](NC(=O)[C@@H1]1CCC(=O)NC1)C(=O)NC(C)(C)CCCF CC(C)(C)OC(=O)CC1CCN(C(=O)N2CC[C@H1]3CCC[C@H1]32)CC1 CC1=CC=CC2=CC(C(=O)N3CC[C@@H1](NC(=O)C=4C(C)=COC=4C)[C@@H1](F)C3)=NN12 C[C@@H1]1CN(C(=O)C2=CC=C(Cl)C=C2)C[C@@H1]1CNC(=O)C=3OC=CC=3C4CC4 CC[C@H1](CNC(=O)C[C@@H1](CC)SC)NC(=O)C1=CC(C#N)=CC2=CC=CC=C12 CCNC(=O)CCCC(=O)N1C[C@H1](NC(=O)C2(S(N)(=O)=O)CC2)CC13CCC3 C[C@H1](NC(=O)C1(C#N)CCCCC1)[C@H1]2CN(C(=O)C=3C=NN(CCF)C=3)CCO2 CC1=CC=C(C(F)(F)F)C=C1[C@H1](C(=O)NC2=CC=CC=C2Cl)N3CC[C@@H1]4C[C@H1]4C3 CN(C)CC1(CC(=O)N2C[C@@H1](O)[C@@H1](CNC(=O)C3=CN(C)N=N3)C2)CCOCC1 CCC[C@](C)(O)C(=O)N1C[C@H1]2CC[C@H1]1[C@H1](NC(=O)CN3C=NC=CC3=O)C2 CC=1C=CN(C[C@H1](C)C(=O)N[C@H1](C)[C@@H1]2CN(C(=O)CCSC(F)(F)F)CCO2)N=1 C#CC1(C(=O)N2CC[C@H1]3CCC[C@@H1](C2)N3CC(=O)NC4=CC=C(Cl)C=C4C)CC1 COCC=1N=N[NH1]C=1C(=O)N(C)C[C@H1]2CCCN(C(=O)C=3C=CN(C4CC4)N=3)C2 CC1(C(=O)NC2(CO)CCCCCC2)CCN(C(=O)C[C@@H1]3C=CCC3)CC1 COCCC[C@@H1](C)C(=O)N1CCC2(CC1)C[C@@H1]2NC(=O)C3=C(F)C=C(C)C=C3F CO[C@H1]1C[C@H1](C(=O)N2CCOC[C@@H1](NC(=O)C3=CN=C4C(=N3)CCCC4)C2)C1 CO[C@@H1](C)CC(=O)NCC[C@H1]1CC[C@@H1](NC(=O)COC2=CC=C3C(=C2)CCC3)C1 O=C(N[C@@H1]1C[C@@H1](NC2=NC=C3C=CN=C3[NH1]2)C14CCC4)C5=C[NH1]C=C(F)C5=O CSCC(=O)N[C@H1]1C[C@H1](C(=O)N[C@H1](C)C2CCOCC2)C1(C)C COC1(CC(=O)N[C@H1](CNC(=O)C2=CN=C(N(C)C)S2)C3CC3)CCC1 CC(C)(C)CC1=NC=C(C(=O)N2CC[C@@H1](CNC(=O)C3CC(C)(O)C3)C24CCC4)O1 CC1=CC=NC=C1C(=O)NCC[C@H1]2CCCN2C(=O)CC3C(C)(C)C3(C)C COC(=O)[C@H1](OC)C(=O)N1C[C@@H1](CNC(=O)C2(C=3C=C[NH1]N=3)CCC2)C4(CC4)C1 C[C@H1](CCC1CCCC1)N[C@@H1](C2=CC=C3OC=CC3=C2)C4=NN=NN4C(C)(C)C C=CC[C@@H1](C(=O)NC/C=C/CNC(=O)C[C@@H1]1SC2=CC=CC=C2NC1=O)C(C)C C=C1CC(C(=O)NC[C@@H1]2C=3C=CSC=3CCN2C(=O)[C@@H1](O)CN(C)C)C1 CNC(=O)C[C@@H1]1CCN1C(=O)CCN(OC)C(=O)CN2CC(C)(C)C2 CCNC(=O)CC(=O)N(CC)C[C@@H1](C)NC(=O)C1=CC=C(Cl)C(C#N)=C1 C=C=C(C)CC(=O)NC1C[C@@H1]2CC(NC(=O)CC(=O)N(C)C)C[C@H1]2C1 CC(=O)N(C)CC(=O)N(C)[C@H1]1CN(C(=O)COC2=CC=CC(C#N)=C2)CC13CC3 C[C@@]12CC3(N)CC(C(=O)N4CC5=CC(Cl)=C(Cl)C=C5C4)(C1)C[C@](C)(C3)C2 CC1=C(C(=O)NCCCCNC(=O)[C@@H1](C)CC2=CC=NC=C2)SC3=CN=CN13 CCCC[C@H1](CC)CC(=O)NCCCC(=O)N1CCN2C=CN=C2C1 C#CC[C@]1(C(=O)N[C@H1](CNC(=O)C2(C)CC3(CC3)C2)C(C)(C)C)CCCO1 CCC(=O)NCC(=O)N[C@@H1]1CCC[C@@]1(C)CNC(=O)[C@@H1]2CCCC3=NC=NN32 CNS(=O)(=O)C1CN(CC(=O)N[C@@H1](C)C2=CC=CC=C2)C1 CC(C)C1=NC=C(C(=O)NC2(C)CC(NC(=O)[C@H1]3NC(=O)O[C@@H1]3C)C2)C=N1 O=C(N=C1C=NN(CCN2CCOCC2)[NH1]1)NCC3(N4CCSCC4)CCCC3 C=C1CC(CC(=O)NC[C@H1](NC(=O)[C@H1](C)SC2=NC3=CC=CC=C3[NH1]2)C(C)C)C1 CCN1C=CN=C1C(=O)N2CC[C@@H1](NC(=O)C=3SC=NC=3COC)[C@@H1](CO)C2 CCN(CCNC(=O)C1=CC(C)=CC(C)=C1N)C(=O)C2=CC3=C(Cl)N=CC=C3S2 CC1(C(=O)N2C[C@@H1](F)C[C@H1](NC(=O)C3(COC(C)C)CC3)C2)CS(=O)(=O)C1 CCN1CC[C@H1](CN(C)C(=O)[C@@H1]2[C@H1]3C[C@H1]3CN2C(=O)C[C@H1]4CCC(=O)N4)C1 CC1CCC(CN(C)C(=O)[C@@H1](O)C2=CC=C(NC(=O)OC(C)(C)C)C=C2)CC1 CNC(=O)[C@H1](C)CN(C)C(=O)C1=CC=CC2=C1CCN(C(=O)OC(C)(C)C)C2 CCOC1=CN=CC(C(=O)NC[C@@H1](F)CNC(=O)C2=CC=NC(C(N)=O)=C2)=C1 CC[C@@H1](C)N1N=CC(C(=O)N(C)CCOCCCNC(=O)C2CC(F)C2)=C1C O=C(CCOC1=CC=CC=C1F)NC[C@@H1](CO)CNC(=O)C2=CC=C(C3CC3)S2 COC[C@@]1(C(=O)N2CC[C@@H1]3CCN(C(=O)C4(C(C)C)CC4)C[C@@H1]3C2)CCCCO1 CC(C)(C)OC(=O)N[C@H1](CF)C(=O)NCCNC(=O)C1=NC=C(Br)C=C1F CC(C)(C)[C@H1](NC(N)=O)C(=O)NC1CC2(C1)CN(C(=O)CC3=C(Cl)C=CC=C3Cl)C2 CCC(=O)N1CSC[C@H1]1C(=O)NCC(C)(C)CN(CC)C(=O)CC2=CSN=N2 CC1=COC=C1C(=O)NCCO[C@@H1]2CCN(C(=O)[C@@H1]3CCCN(S(N)(=O)=O)C3)C2 CC1=CC(C(=O)N[C@@H1](C)[C@@H1]2CCCCN2C(=O)C3=NN=C(O)N=C3O)=C(C)O1 C[C@@H1]1CC[C@H1](NC(=O)CN2N=C(Cl)C=CC2=O)CN1C(=O)C3=CC(Cl)=C(Cl)S3 CC(F)(F)C1(CNC(=O)C=2N=COC=2CNC(=O)C3CCC3)CC1 CC[C@@H1]1CCO[C@@H1]1C(=O)N[C@@H1]2CN(C(=O)C(C)(C)C3CC3)CC24CCOCC4 O=C1NC2=CC=CC=C2N[C@@H1]1C(=O)N3CCC(CCCO)CC3 C=C1CCN(C(=O)C=C2CCN(CC3=CC=C4N=C[NH1]C4=C3)CC2)CC1 CC(C)[C@@H1]1C[C@H1]1NC(=O)[C@H1]2CCN(C(=O)[C@H1]3CCC(C)(C)C3)[C@@H1](C)C2 CC=1C=NN(CCC(=O)N[C@H1]2CN(C3=CC=NC=C3C#N)CC[C@H1]2CO)C=1 CC1=CC(CC(=O)N(C)CCCCN(C)C(=O)/C=C/C(C)(C)C)=CC=C1O C=CCC1=CC=CC=C1C(=O)NCC2(NC3=CN=C(C#N)C=N3)CCCCC2 C#CCN(CC(=O)NC1(CC(N)=O)CC1)C(=O)C2=CC=C(C(N)=O)[NH1]2 CC(C)NC(=O)[C@H1](C[C@H1]1CCC(C)(C)O1)N2CCC3=CC=C(F)C(F)=C3C2 CN(C)C(=O)CCCC(=O)N[C@@]12CC[C@@H1](C[C@H1]1NC(=O)[C@H1]3CCOC(=O)CC3)C2 NC(=O)CSCCC(=O)N[C@]12CCCN(C(=O)C3=CC=NC(O)=C3)C[C@H1]1C2 CC1=CC(F)=CN=C1NC(=O)[C@@H1]2CC23CN(C(=O)C4=CC=C(CO)C=C4F)C3 COC1=CC=C(C(=O)NC23CC(NCC4=CC(Cl)=NC=C4OC)(C2)C3)C(C)=C1C CC1=NC([C@@H1](C)NC(=O)[C@H1]2C[C@@](C)(NC(=O)C3=CN=C(C)S3)C2)=CS1 CN(C[C@H1](O)CN(C)C(=O)[C@H1]1CCC=2N=N[NH1]C=2C1)C(=O)C3=CC=C(Br)O3 O=C(NCC1(NC(=O)[C@@H1]2OC[C@@H1]3COCC[C@@H1]32)CCCCC1)C4=CC(Cl)=CS4 CC(=O)C1=CC=C(NC(=O)NCCOC(F)(F)C(F)(F)F)C(C#N)=C1 C#CCCCC(=O)N1C[C@@H1](F)C[C@H1]1CNC(=O)C2=COC(C(F)(F)F)=C2 C#CCNC(=O)NCCCC(=O)N[C@H1]1CC[C@@H1](NC(=O)[C@]2(C)CC[C@@H1](C)C2)CC1 O=S(=O)([C@@H1]1CCC=CO1)N2C[C@@H1](C(F)F)C3(CCOCC3)C2 C[C@@H1](O)C(=O)N(C)C1CCN(C(=O)[C@@H1]2CCN(C3=CC=CC=C3F)C2)CC1 COC[C@H1](O)C(=O)N1CC(C[C@H1](C)NC(=O)[C@H1]2C[C@H1]2C3CC(F)(F)C3)C1 CC(C)C[C@@H1](F)C(=O)N1CCN(C(=O)C2=CC=CC(C3CC3)=N2)C[C@@H1]1CO CC(C(=O)NCC1=CN(C[C@@H1]2CCCN2C(=O)[C@H1](CO)N(C)C)N=N1)=C3CCC3 COC(=O)C[C@H1](NC(=O)NC1=CC=C2C=CC=NC2=N1)C3=CC=C(C)C=C3C COC1=CC=CC([C@@H1](C)NC(=O)C2CN(CC3=CC=CC(C(F)(F)F)=N3)C2)=C1 C=CC[C@]1(NC(=O)C(=O)NCC2CC2)CCN(C(=O)CC=3C(C)=NSC=3C)C1 CCO[C@H1](CC(=O)N(CCN(C)C(=O)[C@@]1(Cl)CC1(F)F)C(C)C)C(C)C CCOC(=O)C(C)(C)C(=O)N(C)CCCOCCN(C)C(=O)[C@@]12CCCC[C@@H1]1C2 COC1=CN(C)C(C(=O)N2CC[C@H1]3CC[C@@H1](NC(=O)C=CC(N)=O)[C@H1]2C3)=CC1=O CC1=NN=CC(C(=O)N[C@@]2(C(=O)NCC3=CSN=N3)CCSC2)=C1C C[C@@H1](CCCO)CNC(=O)[C@H1]1CC[C@H1](CNC(=O)[C@@H1]2NC(=O)OC2(C)C)CC1 CN1C=C(C(=O)NC[C@H1]2C[C@@H1]2NC(=O)C=3OC=NC=3C(F)F)C(C4CC4)=N1 C[C@@H1](NC(=O)CC=1C=NOC=1)C2(O)CN(C(=O)C=CC3=NC=CS3)C2 CO[C@@H1](C)CC(=O)N[C@@](C)(CNC(=O)C1=C[NH1]N=C1C2=CC=CC=N2)C3CCC3 COCC[C@@H1](CNC(=O)C[C@H1](C)OC)NC(=O)CCC(=O)NCC1=CC=CC=C1 CCC=1C=C(C(=O)NC(C)(C)C2CCN(CC3=NC(C(C)C)=NS3)CC2)N(C)N=1 C=C(C)CC(=O)NCC1=CN(C[C@H1](C)COC)N=N1 C=CCCCC(C)(C)C(=O)N1CC[C@H1](O)[C@@H1](NC(=O)[C@@H1](F)C2CCOCC2)C1 C[C@@H1](CNC(=O)C1(C2CC2)CN(C(=O)C3=CC=CC4=CC=NN34)C1)C5=CC=CS5 CC(C)(C)C[C@H1](NC(=O)N1CC(F)(C2CC2)C1)C3=CC=CC=C3 C[C@H1](CN(C)C(=O)CCC1=CN=CN=C1O)NC(=O)C=2N=NSC=2N CCOC(=O)[C@H1]1CNC[C@@H1]1NCC2=CC=CC(OCC)=C2O C[C@@H1]1CCC[C@](O)(CNS(=O)(=O)C2=CC=C(SC3=CC=C(Br)C=C3)C=C2)C1 C#CCC1(C(=O)N(C)C[C@@H1]2CN(C(=O)C3(C)CC4(CCC4)C3)CCO2)CCCC1 C[C@H1](CC(C)(C)C)C(=O)N(CCCN(C)C)CCNC(=O)[C@@H1]1CC2(CCC2)CO1 COC1=CC=C(C=2N=C(CC3CCSCC3)N(CCC4=CC=NC=C4)N=2)C=C1 COC(=O)CCCN=C(NC1CCOCC1)N2CC[C@H1]3COC(=O)N[C@@H1]3C2 COC1=CC=CC=C1SCC(=O)NCCCC2(NC(=O)CCOCC(C)C)CC2 CN1CCC(C(=O)N2C[C@H1](NC(=O)C3=CN=C4OC=CC4=C3)CC5(CC5)C2)CC1 CCN(C)CC=CC(=O)N1CCC[C@]1(C)C(=O)NCC2(CF)CC2 O=C([C@@H1](O)C1CCOCC1)N2CC[C@]3(CCCN(C4=CC(O)=NC=N4)C3)C2 O=C(N[C@H1]1CCN(C(=O)C=CC2=NC=CS2)C1)C3=C[NH1]N=C3C(F)(F)F CCC(CC)N1N=CC=C1C(=O)N(CCCNC(=O)[C@@H1]2CCCN2N=O)C(C)C CO[C@H1](C)C1=CN(C2(C(=O)N[C@@H1](C)C3=CC=C(O)N=C3)CCOCC2)N=N1 CN(CCCCNC(=O)CNC(=O)NC1CC1)CCCNC(=O)C[C@H1]2CC2(C)C CCCSCCC(=O)N1CCCC(C)(C)[C@@H1]1C(=O)N(C)CC2=NC=NN2C CC1=NC(C(=O)C(=O)NCC2(O)CN(C(=O)C34CC(C)(C3)OC4(C)C)C2)=CS1 CCC=1N=N[NH1]C=1C(=O)N2CC(OCCC(=O)NCCNC(=O)C(C)C)C2 COC1=NC=C(C(=O)N2CC[C@@]3(CCCN3C4=NC=C5N=CN(C)C5=N4)C2)C=N1 CN(C)C1=NC=NC(N2CC[C@H1]3CC[C@@H1](NC(=O)C4[C@H1]5CCC[C@H1]45)[C@H1]2C3)=C1[N+1](=O)[O-1] CN1N=CC(Br)=C1[C@@H1](NC2=CC=CC(CCO)=C2)C3=NN=NN3C4CCOCC4 C=C(C)CONC(=O)[C@H1]1C=CCN(C(=O)[C@H1]2CNC(=O)N2)C1 CC1(C)C(C(=O)N[C@@H1]2CCC[C@@H1]2NC(=O)C3=CC=C(N4CC(O)C4)C=C3)C1(C)C CCCC[C@H1](NC(=O)C1=COCCC1)C(=O)N(C)CCC(C)(C)O N#CC1=CC=CC(OCC(=O)N2C[C@H1](N3C=CC=N3)[C@H1](NC(=O)C=CBr)C2)=C1 CC(C)N1C=C(C(=O)N2CCCN(C(=O)CC(C)(C)O)C[C@H1]2C)N=N1 O=C(NC1=CC(C=2C=C[NH1]N=2)=CC=N1)C3=NC=CC(C4=CC=CC=C4)=N3 C=C(Cl)C(C)(C)C(=O)NC[C@H1]1CCCCN1C(=O)C2=CN=CC(N3CCCC3=O)=C2 CN(CC(=O)N[C@@H1]1CCC[C@H1]1NC(=O)C2=CC(F)=CC(OC(F)F)=C2)C3CCC3 C=C[C@](C)(O)CC(=O)N1CCC2(CC1)CN(C(=O)[C@H1]3CSC(C)=N3)CCO2 O=C(CCC(CF)CF)NC1=NC=CC2=CC=NC=C12 CC1=CC(NC(=O)CO[C@H1]2C[C@@H1](NC(=O)CC3=CC=CN=C3)C2)=CC=C1F CC[C@@H1]1CCN(C(=O)C2=CC=C(OC)C(O)=C2)[C@H1]1CNC(=O)CC(C)(F)F COC1=CC=C(/C=C/C(=O)N2CC[C@@H1](C)[C@@H1](N(C)C(=O)[C@@H1]3CC=CCO3)C2)C=C1 C=C[C@H1]1C[C@H1]1C(=O)N2CC[C@@](C)(CCNC(=O)C3CCC=CCC3)C2 CN(CCC1CCN(C(=O)C=CC2CCOCC2)CC1)C(=O)[C@H1]3C=CCCC3 CC1=NC(C)=C(C(=O)NC[C@H1]2CCC23CCN(C(=O)C4(Cl)CC4)CC3)[NH1]1 CC[C@H1](SC)C(=O)NC[C@H1]1CN(C2=CC(=O)N(C)C=N2)CC[C@]13CCOC3 CC1=CC(Cl)=CC(C)=C1C(=O)N2CC(C[C@@H1](C)NC(=O)[C@@H1]3CC(C)(C)CO3)C2 C=CCO[C@@H1](C)C(=O)N1CCN(C)[C@@H1](C(=O)NCC2=CC(COC)=NO2)C1 CC[C@H1](O)C(F)(F)C(=O)N1CC(C2(NC(=O)C[C@H1](C)N3C=CN=C3)CC2)C1 O=C(NC[C@@H1]1CCCN(C(=O)C=2C=CC(=O)OC=2)C1)[C@@H1](F)C3(O)CCCC3 COCCNC(=O)[C@@H1](C1=CC(Cl)=CS1)N2CCOC3=CC=C4C=CC=CC4=C3C2 C=CCN(CC=C)C(=O)[C@]1(OC)CCN(C(=O)CSCCC(C)C)C1 COC1=C(C)C=C(Cl)C=C1C(=O)N2CCC[C@@](C)(NC(=O)[C@H1](CO)NC(N)=O)C2 C[C@@H1](C(=O)N[C@H1]1C[C@]2(CCCCN2C(=O)CSC[C@H1]3CCCO3)C1)C(F)F CCC1=CN=CC=C1C(=O)N2CC(CC)(C(=O)NCC3=CC=CC=N3)C2 C#CC[C@H1]1CN(C(=O)[C@@H1]2CC[C@@H1](OC)CC2)C13CCC3 C[C@H1](CC1=CC=CO1)C(=O)NNC(=O)NCC(C)(C)NC(=O)C(F)(F)F CC(C)C1=CC(C(=O)N2C[C@H1](NC(=O)C(C)(C)O)CC3(CCOCC3)C2)=NO1 N#CCC(=O)N1CC2(C[C@H1](NC(=O)C3=CC(C4=CC=CC=C4)=CS3)CO2)C1 CCOCC[C@H1](NC(=O)[C@@H1]1CC(=O)N(OC)C1)C(=O)NCC2(Cl)CCC2 CC1=C(O)C=C(N)C=C1C(=O)N2CC[C@@H1](C)[C@@H1](NC(=O)CN(C)C(=O)C(C)C)C2 C=C=C[C@@H1](C)C(=O)N[C@@H1](CC=C)CNC(=O)C1=C(C)OCCS1(=O)=O CC(C)(C)C1=NC=C(C(=O)N2CCOC[C@@H1]2C[C@H1](O)C3=CC=CC=C3)[NH1]1 C[C@@H1]1CN(C(=O)C[C@H1]2CCC[C@@H1](NC(=O)C3=CSC(Cl)=C3)C2)CCCO1 CCC1=CC(NC(=O)NC[C@@H1](F)CCNC(=O)OC(C)(C)C)=CC(C(F)(F)F)=C1 COC1(CNC(=O)[C@H1]2CCC(C)(C)OC2)CN(C(=O)C3=NC=CN4C=CN=C34)C1 CCC=1[NH1]N=C(C(=O)N[C@@H1]2C[C@@H1](O)CN(C(=O)C3=CC=C(Cl)C=C3)C2)C=1C CC1=NC=CC=C1CC(=O)N2CCO[C@@H1]3CN(C(=O)CCC=4C=NOC=4)C[C@@H1]32 CC(C)(C)[C@@H1](C#N)C(=O)NC1=CC=C(OC2=CC=CC(Br)=C2)N=C1 CCN1N=CC(Br)=C1C(=O)NC[C@H1]2COCCN2C(=O)[C@H1](C)NC(N)=O CO[C@H1](C)CCC(=O)NCC[C@@]1(O)CCN(C(=O)C2=CN=CN(C)C2=O)C1 N#CC1=CC=C(C(=O)N[C@@H1]2CN(C(=O)[C@@H1]3C[C@H1]3C4=CC=C(Br)C=C4)CCC2(F)F)S1 CCO[C@H1](CC)C(=O)N1CC2(C[C@@H1](NC(=O)C3=CC=C([C@H1](O)CF)C=C3)CO2)C1 N#CC1=CN=CC(NC(=O)C2([C@H1]3CCCN3C(=O)CCN4CCOCC4)CC2)=C1 COC1=CC(CCC(=O)N2C[C@@H1]3C[C@H1](C2)CN(C(=O)[C@H1]4CCCS4)C3)=CC=C1F C[C@H1](NC(=O)[C@@H1]1CN(C(=O)C(C)(C)CC2CC2)CCO1)C3=CCN(C)CC3 COC1(CC(=O)N2C[C@@H1](F)C[C@H1]2C)CN(C(=O)C=3C=C(C4CC4)ON=3)C1 C[C@@H1]1C[C@@H1]1NC(=O)[C@@H1](NC(=O)CC[C@@H1]2CC2(F)F)C3=CC=CO3 N#CC1(CC(=O)N2CCC[C@H1]2[C@H1]3CCCN3C(=O)C4=CC=C(Cl)O4)CC1 CCOC(=O)C1=NC(OC2=CC(C(=O)OC)=CC=C2C)=NC=C1Cl CO[C@@H1]1CN(C(=O)C2=CN=CC(Cl)=C2Cl)C[C@H1]1NC(=O)CS(=O)(=O)C(C)C CCC=1SC(C(=O)N[C@H1](C)CN(C)CC2=NC(C)=NO2)=CC=1C CN(C)S(=O)(=O)NCC(=O)NC[C@@]1(C)CCN(C(=O)C2=CC=3SC=CC=3N2C)C1 CO[C@@H1]1C[C@@H1](CNC(=O)CCNC(=O)C=CCl)N(C(=O)CC2(CO)CC2)C1 CC[C@H1](C)[C@@H1](C(=O)NCC1=CC=NC(O)=C1)N(C)C(=O)COCCN(C)C CC(C)CC[C@H1](O)C(=O)N1CC[C@@H1]2CCC[C@@]21C(=O)N[C@@H1]3CC(C)(C)OC3=O CC[C@@H1](CC(=O)N1C[C@@H1](C(=O)OC)C2=C(C)C=CC=C21)C3=CC=C(OC)C=C3 C=CCCC(F)(F)C(=O)NC1CC([C@@H1](F)C(=O)NCCCC(C)(F)F)C1 CCCC1=CC=C(C(=O)N[C@@H1]2CN(C(=O)C=C[S@@](C)=O)C[C@H1]2O)[NH1]1 C#CC[C@@](C)(NC(=O)C1=CC(C)=C(C)C=N1)C(=O)N[C@H1]2CCO[C@H1]2C COC1=CC(C(=O)N[C@](C)(CO)CNC(=O)CCCN(C)N=O)=C(OC)C=C1Cl COC1=CC=C(C(=O)N[C@@H1]2CC[C@H1](NC(=O)C[C@@H1](O)CN(C)C)C2)C([N+1](=O)[O-1])=C1 C=CC1(C(=O)NC[C@@H1]2C[C@@H1](NC(=O)C3=CC=NC4=NC=CC=C34)C25CCC5)CC1 COC=1C=CSC=1C(=O)NC[C@H1]2C[C@@H1](C(=O)NC[C@@H1]3CC4=CC=CC=C43)C2 CC1=CC=C(CN(C2CC2)[C@@H1](C(=O)NC3COC3)C4=NC5=C(S4)CCCC5)C=C1 O=C(CC[C@@H1]1CCOC1)NC[C@@]2(F)CCCN(C(=O)C[C@@H1]3CCSC3)C2 CC(C)(CC(=O)NC[C@@H1]1C[C@H1]1CNC(=O)[C@@H1]2CCCN2C=O)CC(F)F O=C(NCCCCCNC(=O)[C@@H1]1C[C@H1]1C2CC(F)(F)C2)[C@H1]3CC4=CC=CC=C4O3 CC(C)(CCNC(=O)[C@H1]1CC2CCC1CC2)NC(=O)COCC=3N=C[NH1]N=3 COC1=CC=CC(C(=O)N2CCN(C(=O)CCCC3CCCC3)C4(CCC4)C2)=N1 CCN(CC)[C@H1](C)C(=O)NC1(C(=O)N[C@@H1]2CCC(=O)N(C)C2)CC(CO)C1 CN=C1N=C(C(=O)N2CC[C@](O)(CNC(=O)[C@@H1](O)C3CC3)C2)C=C(C)[NH1]1 O=C(NC[C@H1]1CCN1C(=O)CC=2C=N[NH1]C=2)C=CC3=CCC4(CCOCC4)OC3 CCOC(=O)C=1C=C(C(=O)N[C@@H1](C)[C@H1](C)NC(=O)[C@H1]2CC[C@H1](C)CC2)ON=1 C[C@@]1(C(=O)NCC[C@H1](O)CNC(=O)C23C4C5C2C6C3C4C56C(N)=O)C[C@@H1]7C[C@@H1]7C1 CCN1CCN([C@H1](C(=O)NC2CC(F)(F)C2)C3=CC=C4C(=C3)OCCO4)[C@@H1](C)C1 C[C@@]1(CNC(=O)C2(N3C=CC=N3)CC2)CC(F)(F)CN1C(=O)CCCC#N CCCCCC1=CC=CC(CC(=O)N[C@H1](C)C2CN(C(=O)C3=CN=C(S)N=C3)C2)=C1 COC(=O)COC1=CC=CC(C(=O)N2CCCC[C@@H1]2CCNC(=O)CO)=C1 CN1C=NC=C1C(=O)N[C@H1]2CN(C=3C=CN4N=CC(I)=C4N=3)CC2(F)F CCCC[C@H1](O)C(=O)N[C@H1]1C[C@@H1](CCNC(=O)C2=NOC(CC)=C2C)C1 CCC=1SC=CC=1C(=O)N[C@H1]2C[C@H1](NC(=O)C=3C(CO)=NOC=3C)C24CCC4 CC=1C=NN(CC(=O)NC[C@@H1]2CCN2C(=O)[C@@H1]3CC4=CN=CN4C(=O)N3)C(=O)C=1 FC(F)(F)CSCCNC1=NC=C(S(=O)(=O)NCC2=CC=CC(Cl)=C2F)C=C1Cl CCN(CC)C[C@H1](F)C(=O)NC[C@@H1]1C[C@@H1](O)CN1C(=O)CN2CCCS2(=O)=O COCC=1C=C[NH1]C=1C(=O)NCC[C@@H1](C)NC(=O)C2(C3=CC=C(C#N)C=C3)CC2 CCN1C(=O)CC[C@@H1]1CC(=O)N2C[C@H1](C)[C@H1](NC(=O)C(F)(F)C(F)(F)C(F)F)C2 CN1C=NC2=CC(C3=CN=CN=C3C(=O)N4CCCCC(F)(F)C4)=CN=C21 C=C(C)C(C)(C)C(=O)NCC[C@H1]1CCCN1C(=O)C2=CC3=NC=CC=C3O2 O=C(CCC1=NC=C[NH1]1)NC[C@@H1]2C[C@H1]3CC[C@@H1]2N3C(=O)C4=CC=C5ON=CC5=C4 COCCN(CCO)C(=O)C[C@H1]1CN(C(=O)CN2C=NN=C2O)C(C)(C)C1 C[C@@H1]1CN(C(=O)C2(N3C=NN=N3)CC2)CC[C@@H1]1CNC(=O)COC4=CC=CC=C4 COC=1C=C(C)SC=1C(=O)NC2CCN(C(=O)[C@@H1]3COC4=CC=CC=C43)CC2 O=C(NC1=NC2=CC=CC=C2O1)N3CC(O)(C4CC4)C3 COCC1(CCNC(=O)C2=CCCN(C(=O)[C@H1](O)C3=CC=CO3)C2)CCC1 C[C@@H1]1[C@@H1](NC(=O)C2(C3CCC3)CCC2)C[C@H1]4CC[C@H1]1N4C(=O)CC5CC(F)(F)C5 O=C(CCCCC1=CC=CC=C1O)NCCCCCCN2C=C(CCCO)N=N2 COC[C@H1](NC(C)=O)C(=O)N1C[C@@H1]2CC[C@H1](C1)N2C(=O)[C@H1](CO)NC(N)=O CNC(=O)[C@H1](C)NC[C@@H1](O)CC1(CO)CCOCC1 CCC(F)(F)C(=O)N1C[C@H1]2CC[C@H1]1[C@H1](NC(=O)[C@H1](CCSC)N(C)C)C2 CC1=NOC(C)=C1[C@H1](C)CC(=O)NCC(CN=C2N=C(C(F)(F)F)C=C(C)[NH1]2)=C C[C@]1(CCNC(=O)C2CC3(CCN(C(=O)C4=CSC(F)=C4)C3)C2)CC1(F)F O=C(NCC1=CC(C(=O)NC[C@@H1]2C[C@H1](O)C23CCC3)=CS1)[C@H1]4CC[C@H1](O)C4 CC1=NC=C(C(=O)N2[C@H1](C(=O)NCC3=NC=CC(C)=N3)CCC24CC4)C(C)=N1 O=C(C=1C=C(C2=CC=CS2)ON=1)N3CC(NC(=O)[C@@]45CC[C@@H1]4C5)C3 CS[C@H1](C(=O)N1CCC[C@H1]2[C@H1](CCCN2C(=O)C3C4(CC4)C35CC5)C1)C(C)(C)C NC(=O)N1CC(C(=O)N[C@H1]2C[C@H1](CNC(=O)C3=CN=CC(Cl)=C3)C2)C1 CN(CCNC(=O)CCF)C(=O)C1(OC=2C=NN(C)C=2)CCCCC1 COCC[C@@H1](C)C(=O)NCC1(OC)CN(C(=O)C2(F)CCC(C)CC2)C1 CC(=O)NC1=NC(CN2C[C@@H1]3C[C@]3(C(=O)N[C@@H1](C)CC#N)C2)=C=CC=C1F CC(C)(NC(=O)C#C[C@H1]1CCCCO1)[C@@H1]2CCCN2C(=O)[C@H1]3C[C@@H1](O)C3 CCCC(C)(C)C(=O)N[C@@H1]1C[C@H1](O)[C@H1]1CC(=O)NCC2(O)CCOCC2 C=CCO[C@@H1]1CCN(N2CCCC3=C(CC)C=CC=C32)C1 CC1=CC(NC(=O)[C@H1](F)N2C=CN=C2)=C3N=C(C)SC3=C1 CCC[C@H1]1C[C@@H1]1N=C2[NH1]C(=NCC3=CC=CC(Br)=C3F)C4=CC=C(OC)C=C4[NH1]2 COC1(OC)CC[C@@H1]1C(=O)OC[C@@H1]2CCC3(CO2)CN(C(=O)OC(C)(C)C)C3 CC1(C(=O)N[C@@H1]2CCCC[C@@]23CCN(C(=O)CC(F)(F)F)C3)CC1 CC(C)(C)O[C@@H1](C(=O)N1CC[C@@H1](NC(=O)C2(C#N)CCC2)C1)C3=CC=CC=C3 CSCCC(C)(C)C(=O)NCC=1C=COC=1C(=O)N2CC3(CN(C)CCO3)C2 O=C(CCOC1CCC1)N2C[C@@H1]3C[C@H1](C2)CN3C(=O)C4=CC=CN(O)C4=O CN1C(C(N)=O)=NC=C1NC(=O)NC2(C3=CC(Cl)=CC(Br)=C3)CCC2 CC(=O)NCCC(=O)NC[C@@H1]1CN(C(=O)C23CCC(C2)C3)C4(CCC4)C1 CC=1SC=CC=1C(=O)N[C@H1]2CCCN(C(=O)C3=N[NH1]C=C3C(F)(F)F)CC2 C[C@@](CNC(=O)C1=CC=NC2=NC=CC=C12)(NC(=O)[C@H1]3CCC[C@@H1]3O)C4CC4 COC1=C(COC(=O)COC[C@@H1]2CCOC2)C=CC=3N=COC1=3 CCC[C@@H1](C(=O)NC[C@](C)(NC(=O)COC1CC1)C(C)C)C(=O)OC CC(C)C1=N[NH1]C=C1C(=O)NCCC2(NC(=O)[C@H1]3NC(=O)C[C@@H1]3C)CCC2 COC[C@@H1]1CN(C(=O)C2=NOC3(CCC3)C2)CCN1C(=O)C4=CC=C(OC)C=C4 C=CCC1(NC(=O)C=2OC(CC)=NC=2C)CN(C(=O)C3=NC=CC(Cl)=C3O)C1 CC=1N=C(CCNC(=O)[C@@]2(C(=O)O)CCC3=CC=CC=C3CC2)SC=1C O=C(C=CC1CCCC1)N2C[C@H1]3[C@H1](CNC(=O)C4(CCO)CC4)C[C@H1]3C2 C[C@@H1](CC(N)=O)C(=O)NC1CCN(CCNC(=O)COC2=CC=CC(F)=C2)CC1 C/C=C/CCCCC(=O)NCCC1(OC)CN(C(=O)C=2C=NN3C=CC=CC=23)C1 CC1=CC=C2C(CC(=O)N[C@@]3(CF)CCN(C(=O)CCCC(F)F)C3)=C[NH1]C2=C1 CN(CCN1CCCCC1)C(=NCC2=CC=CC=C2)NC[C@@]34CCCN[C@@H1]3CCC4 CC(=O)N[C@@H1](C(=O)N1CCC[C@@H1]1CNC(=O)CCC2=CC=C(F)N=C2)C(C)C CONC(=O)C(=O)N[C@@H1](C)[C@H1]1CCCN1C(=O)C=2C=NSC=2 COCC1=NC=C(C(=O)NC[C@H1]2[C@H1](O)[C@H1](O)CN2C(=O)C3CC4(CSC4)C3)S1 CC1=CC(C(=O)N2CC[C@H1](C(=O)NC3=CC=C(C)C=C3C)C24CC4)=C(C)[NH1]1 CC[C@@H1](CN(C)C(=O)[C@H1](C)OCC(C)C)NC(=O)C1CCN(S(=O)(=O)NC)CC1 CN(CC(=O)N1C[C@H1]2CCCC[C@]2(CN=C3[NH1]N=C(C#N)S3)C1)S(C)(=O)=O CC(=O)NCCNC(=O)[C@H1](NC(=O)[C@H1]1OCCCC1(C)C)C(C)(C)C CCC(C)(C)C(=O)NCCC[C@H1](O)C(=O)N1CCC[C@H1](N2CCC2)C1 CC1=CC(C(=O)N2CC[C@@H1](NC(=O)C(F)(F)CO)[C@@H1](O)C2)=CC(C)=C1Br C[C@@H1]1CCC(=CC(=O)N2CCC3(CC2)CC(NC(=O)C[C@@H1]4CSCCS4)C3)C1 CCN(CCCNC(=O)C1=C(C)C2=CC=CC=C2OC1=O)C(=O)[C@@H1]3CCCCO3 CCCC1=CC(C(=O)NCC[C@H1](O)CNC(=O)[C@H1]2CCC2(C)C)=N[NH1]1 CC(C)[C@H1](CNC(=O)C=1N=NN(C)C=1C(F)F)NC(=O)C2CS(=O)(=O)C2 CCC=1C=C(C(=O)N[C@@H1](CNC(=O)CC2=CN=CN=C2O)C(C)C)ON=1 CN(C)CC[C@@H1](C(=O)NCCOCCNC(=O)C=1C=CN(C)C=1)N(C)C [N-1]=[N+1]=NC1=CC=CN=C1C(=O)N2C[C@H1]3[C@H1](NC(=O)C=4N=C[NH1]C5=NC=NC=45)[C@H1]3C2 CC1=CC=C([C@H1](C)NC(=O)[C@@H1]2C[C@@H1]2C(=O)NC3=CC=C(I)C4=CC=CN=C34)C=C1 CC[C@H1]1C[C@@H1]1C(=O)N2CC(C3C(NC(=O)CCCOC4=CC=CN=C4)CO3)C2 O=C(N[C@H1]1CCCN(C(=O)COC(F)F)C[C@H1]1F)CC=CC(CCCCO)=C CC(C)(NC(=O)CCC1=CN=CS1)[C@@H1]2CCN(C(=O)C(F)(F)C3=NC=CS3)C2 CC(Cl)(Cl)C(=O)N[C@@H1]1CCN(C(=O)C(F)=CC2=CC=CN=C2)CC1(C)C CC(C)(C)COCCC(=O)N[C@@H1](C(=O)NC[C@H1](O)CN1C=CC=N1)C2=CC=CS2 COC1(CNC(=O)C2=CON=C2C(C)C)CN(C(=O)C3=C(F)C=CC(Cl)=C3N)C1 CC=1N=C(C(=O)N2CCC([C@@H1]3CCN(C4=NC=NS4)C3)CC2)C(=O)[NH1]C=1C CCCCC[C@H1](O)C(=O)NC[C@@H1]1[C@H1](CC)CCN1C(=O)C2=CC=C(Cl)C=N2 CC1=CC(C#N)=CN=C1C(=O)N[C@@H1]2CC[C@@H1](C)N(C(=O)C=3OC=C(C)C=3C)C2 C#CC(C)(C)C(=O)NCCOC1CCN(C(=O)C[C@@H1]2C[C@H1]3CC[C@H1]2C3)CC1 CCC1=CC=CC=C1OCCC(=O)N2CC(O)(CNC(=O)CC3=NN=CN3C)C2 CN1N=CC=C1[C@H1](O)C(=O)NCCC2(NC(=O)[C@H1](O)C3CCCCC3)CC2 CCC=1OC=NC=1C(=O)NCC2(NC(=O)C3CC(=C4CC4)C3)CCCCCC2 CCOC1(C(=O)NC[C@H1](C(=O)NC[C@@](C)(O)C2CCCC2)N(C)C)CC1 CC(C)=CCCC(=O)N[C@H1](CNC(=O)[C@]12C[C@H1]1COC2(C)C)C3=CC=CC(C)=C3 C=CN1N=NC=C1C(=O)N2C[C@H1]3C[C@@H1](NC(=O)C(C)=C(C)CC)[C@H1]2C3 CCOC[C@H1](C)C(=O)N[C@@H1]1CCN(C(=O)C2=CC=NC(C(F)(F)F)=N2)C[C@H1]1CC CCCN(CCNC(=O)CN1C=C(C2CCC2)N=N1)C(=O)C=CSC CCC1=NC=CC=C1C(=O)N[C@@H1]2CN(CC3=CC4=CC(OC)=CC=C4[NH1]3)C[C@H1]2F C[C@@H1]1CCN(C(=O)C2=CC=C(N(C)C)N=N2)CCN1C(=O)CCCSC(C)(C)C CC1(C)[C@H1](C(=O)NCCC(C)(C)NC(=O)[C@H1]2CCCN2C3CCCC3)CC1(F)F CCC1=CN=CC(C(=O)N2C[C@H1]3C[C@H1]2CC[C@@H1]3NC(=O)C4=CC(C)=NC=N4)=C1 O=C(C[C@H1]1CCCN(C(=O)[C@H1]2C[C@@H1]2C3CCC3)C1)NCCOCC(F)F CC1(C)CO[C@@H1]1C(=O)N[C@H1]2CCSC23CN(C(=O)COC[C@H1]4CCOC4)C3 C[C@H1](C(=O)NCCCC1CN(C(=O)C=CI)CCC1)N2CCCCC2 COCC1=NC(N[C@H1](C)CC2=CN=C[NH1]2)=CC(=N[C@@H1](C)C3=NC=C(F)C=C3F)[NH1]1 CCC1=CC(C(=O)N[C@H1]2[C@@H1]3CN(C(=O)[C@H1](C)P(C)(C)=O)C[C@@H1]32)=NN1CCO C=CCCCCCCC(=O)N1CC[C@@H1](C2CC2)[C@@H1]1C(=O)N3CC(=C)C3 CC1=NN(C)C(N)=C1C(=O)N[C@@H1]2CN(C(=O)[C@@H1](C)N3CCC3)C(C)(C)C2 C[C@@H1](C(=O)N[C@H1](CNC(=O)C1=CSC=C1Br)C2CC2)C(C)(F)F CCC(C)(C)NC(=O)[C@H1](C1=CC(Cl)=C(OC)C=C1Cl)N(C)CCN2CCCCC2 C[C@@H1](CCNC(=O)[C@H1]1CCC2=C(Cl)C=CC=C21)NC(=O)CC(C)(C)C C#CC1=CC=C(C(=O)N2CC[C@](F)(C(=O)N[C@@H1](CO)[C@@H1](C)O)C2)O1 C[C@H1](C(=O)N1CC(O)(CN(C)C(=O)[C@@H1]2CNC(=O)C2)C1)C3=CC=NN3C C=CCCC(=O)N1CCN(C(=O)[C@@H1]2CCCN(C(=O)C(C)C)C2)C[C@H1]1C(F)F CC1=NC(O)=NC(C)=C1C(=O)NC[C@@](C)(CO)NC(=O)[C@@H1](C)C(C)(C)C O=C(NCC=1OC=NC=1C(=O)N[C@@H1](CO)[C@@H1]2CC=CCC2)C3=CC=CN=N3 CN1N=C(C(=O)N2CCC[C@](O)(CNC(=O)CN3N=CN=N3)CC2)C(Cl)=C1Cl O=C(CCN1C=C(Br)C=N1)N[C@@H1](CC2=C(Cl)C=CC=C2Cl)C(=O)O C[C@@H1](NC(=O)[C@]1(C2=CC=CC=C2)C[C@@H1](F)C1)C(C)(C)NC(=O)C3=NC(Cl)=C(Cl)S3 C=CCN1N=NN=C1[C@@H1](CCCC(C)(C)C)NC2COC(C)(C)[C@H1]2C CC1=C(CCC(=O)N2CCCO[C@@H1](CNC(=O)[C@@H1](O)C3CCC3)C2)C=NN1C CCN1C[C@@H1](C(=O)N2CC[C@@](F)(C(=O)N3CC(F)C3)C2)CC1=O CC1(NC(=O)[C@@H1]2CCCC3=CN=CN32)CN(C(=O)CCC4CCOCC4)C1 CO[C@@]1(C(=O)NCCN(C)CCO)CCN(C(=O)C2=CC=C(F)C(C)=C2)C1 C[C@@H1]1C[C@H1](C(=O)NC2(CO)CN(C(=O)C[C@H1](C)C3=CC=CC=C3)C2)CCC1=O COC[C@H1](OC)C(=O)N1CC(OCCNC(=O)CCC2=CN=C(C)O2)C1 CSC1=NC=CC(=NC[C@H1]2C[C@@H1]2C3=CC=CC(Br)=C3)[NH1]1 CC=1N=C[NH1]C=1CC(=O)N2CCC[C@@H1]3[C@@H1](NC(=O)CC4CCSCC4)C(C)(C)[C@@H1]32 CC1(CNC(=O)C(C#N)=CC2CC2)CCN(C(=O)[C@H1](F)C3=CCCCC3)CC1 COC(=O)C1=CC=C(CN[C@H1]2C[C@@H1]2C(=O)NCC3=CC=CC4=CC=CC=C34)[NH1]1 CCN(CCNC(=O)C=1C=CN(COC)N=1)C(=O)C2=CC=C(OC)C(OC)=N2 CC[C@@H1](CN(C)C(=O)C1=CC=NC(O)=C1)NC(=O)[C@@H1]2CCCCC(F)(F)C2 C[C@H1](F)CCNC(=O)[C@@H1]1CN(C(=O)C2CC3(CC3)C2)C[C@H1](C)O1 CC1(C)OCC[C@H1]1C(=O)N2[C@H1]3CC[C@@H1]2C[C@H1](NC(=O)CC4CCSCC4)[C@H1]3F CC[C@H1](C#N)C(=O)NC1(C(=O)N(C)CCN=[N+1]=[N-1])CSC1 NC(=O)C1(CNC(=O)[C@@H1]2CN(C(=O)C=3C=C4C=CC=NN4C=3)CCO2)CCCC1 O=C(NC1=NC=C(CC2=CC=C(F)C=C2)S1)C3=CC(C4CCNCC4)=NO3 CC[C@@H1]1OCC[C@H1]1C(=O)N[C@@H1]2C[C@H1]2NC(=O)C3CCCC3 COCC(COC)NC(=O)[C@H1](CCF)NC(=O)CC=1C=NOC=1 C/C=C/C[C@@H1](NC(=O)CN1N=C(C)N=C1C)C(=O)NCCCCNC(N)=O CC1=CSC(Cl)=C1C(=O)N(C)C[C@H1]2CCN(C(=O)C3=CC=CC([S@](C)=O)=C3)C2 C=C(F)C1(CC(=O)NCC[C@@H1](C)N(C)C(=O)C2=NN3C=CC=NC3=C2Cl)CCC1 CC(C)N1C[C@@H1]2C[C@H1]1CN2C(=O)NC3=CC=NC(C(F)(F)F)=C3 C[C@H1](CNC(=O)C1=CC=C(O)C(F)=C1)CNC(=O)C2=CC3=C(Cl)N=CC=C3O2 CCCN1C[C@@H1](CNC=NC2=C(C(=NCCCC#N)[NH1]CC2)COC)CC1=O CC1=CC(C)=C(CC(=O)N(C)C2CCC(NC(=O)C(C)(C)[C@@H1]3CCCO3)CC2)S1 CC1(C)[C@H1](C(=O)N[C@H1]2[C@H1](O)[C@H1]3CCO[C@@H1]23)CCN1C(=O)CCC4=NN=CS4 O=C(NOCC1CCCCC1)[C@@H1]2C[C@H1](O)CN2C(=O)C3=CN=C[NH1]3 CN(CC1(O)CN(C(=O)C2CCN(CCF)CC2)C1)C(=O)[C@H1]3CCCN3N=O C[C@]1(F)CCN(CCNC(=O)C2(C3=CC=CC=C3C=4N=N[NH1]N=4)CCCCC2)C1 CCOCCC(=O)N1CCC=2SC(C3=CC=CC(CC(=O)N(C)C)=C3)=NC=2C1 O=C(CO)N1CC[C@@H1]2CCN(C(=O)CC3=CC=C4C(=C3)CCO4)[C@H1]2C1 C[C@H1](CC#N)C(=O)NC[C@@H1](C)N(C)C(=O)CC1=CN=CN1C COC1=NSC=C1C(=O)NC[C@@H1](C(=O)N(C)CCN=[N+1]=[N-1])C(C)(C)C N=C1[NH1][NH1]C(C(=O)N[C@H1]2CCN(C(=O)C3=C(Cl)CC3)C2)=C1Br NC(=O)C=1C=NN(CC(=O)N2C[C@H1](NC(=O)C3=CC(Cl)=CS3)[C@@H1]4C[C@@H1]42)C=1 CC[C@@]1(C(=O)N(C)C[C@H1](O)CNC(=O)CO[C@H1]2CC[C@H1](O)C2)CCCO1 O=C(C1=CC=C(F)C2=CC=CC=C12)N3C[C@H1]4C[C@]4(C(=O)NC5=NC=CC=C5Br)C3 CC1(C)C[C@@H1]1C(=O)N2CCC3(CCC3)[C@H1](NC(=O)C4=CC=CC(F)=C4Cl)C2 CCN(CC)C(=O)[C@H1]1CCCN(C[C@@H1]2C(C)(C)C2(F)F)C1 O=C(N1CCCN(C2=NC=CC=N2)CC1)[C@]3(F)C[C@H1]4CNC[C@@H1]3C4 C#CC[C@H1](NC(=O)CCN(CCO)C(=O)CN1C[C@@H1]2C[C@H1]2C1)C(=O)OCC CO[C@H1]1[NH1]CC(=N[C@@H1](CNC(=O)OC(C)(C)C)C2CC2)C1 CCN1C(=NN=C1C(=O)NC[C@@]2(O)CCN(C(=O)C3=CC=NC=C3C)C2)CCC CC[C@H1](O)C(=O)NCCCOCCN(C)C(=O)C1=NC2=NC=C(Br)C=C2[NH1]1 NCC1=CCN(C(=O)[C@@H1]2CCCN(CC3=CC4=CC=CC=C4C=N3)C2)CC1 C[C@H1]1CC[C@H1]1CC(=O)NCCO[C@@H1]2CCN(C(=O)C3=CC=C(N(C)C)C=C3)C2 COC1=C(C(=O)N2C[C@H1]3CC[C@H1]2[C@H1](NC(=O)CCC4(C)CC4)C3)C=CN=C1Cl NC1=CC=CC(F)=C1C(=O)NC[C@@H1]2COC[C@H1]2NC(=O)CSCC(F)(F)F CC(=O)N1CC(C(=O)N(C)[C@@H1]2CCCN(C(=O)[C@@]3(C#N)C[C@H1]3C(F)(F)F)C2)C1 CC(C)(C)C1=CC=C(C(=O)C2=NC(N3C=CN=C3)=CS2)C=C1 COC1=CC(C)=CN=C1C(=O)N(C)C[C@@H1](C)N(C)C(=O)C2=CC(OC)=NC=C2Cl COC(=O)C1=CC(O)=NC2=C1CN(C(=O)[C@H1]3CC34CCCC4)CC2 CCOC1CC(C(=O)N[C@H1](CC(N)=O)C2=CN(CC3=NN(C)C=C3C)N=N2)C1 COC1=CC=CC=C1CC(=O)N2CCC3(CN(C(=O)C4=C(Cl)C=NN4C)C3)C2 C[C@@]1(C(=O)N2CC(OCCC(=O)NC[C@H1]3C[C@H1]4CC[C@H1]3C4)C2)CC=CCC1 CN1N=NN=C1[C@H1](NCC(=O)N2CCCCC2)[C@H1]3CC34CCOCC4 CC[C@H1](CCOC)C(=O)N1CC(COC)(NC(=O)C2=CC3=CC=CC(C)=C3[NH1]2)C1 C[C@H1]1[C@@H1](C)[C@@H1]1C(=O)N2CCN(C(=O)C3(F)CCCCC3)C[C@@H1]2CC4CC4 C[C@H1](CC1CCOCC1)NC2=CC=CC3=CC=C(F)C=C23 CCC1=CC=C(C(=O)NCCC2CCN(C(=O)CC[C@@H1]3CCC(=O)C3)CC2)C=C1 CCN(CCCNC(=O)C1=CC=CC(CO)=N1)C(=O)C2=CC=C(C#N)C=N2 C=CC[C@@H1](C)C(=O)NCCCCCNC(=O)[C@@H1]1C=C[C@@H1](NC(=O)C(F)(F)F)C1 C[C@@H1](CCNC(=O)C1=NC=C(F)C=N1)N(C)C(=O)C23CC(C(C)(C)C)(C2)C3 C=CC[C@@H1](C)C(=O)N1[C@H1]2CC[C@@H1]1C[C@H1]2NC(=O)C3(N=[N+1]=[N-1])CC3 CC=1SC(Br)=NC=1C(=O)N[C@H1](CNC(=O)[C@H1]2C[C@@H1]3C[C@@H1]3N2)C4CC4 CC(C)C(C)(C)C(=O)N[C@H1]1C[C@H1](CNC(=O)[C@H1]2CCC[C@@H1](CC(F)(F)F)C2)C1 O=C(CO)N(C1=CC=CC=C1)[C@@H1]2CCC23CCN(C(=O)C=C4CC4)CC3 CCC(CC)N1CC[C@](CC2=CC=CC=C2)(C(=O)N3CCO[C@H1](C(=O)OC)C3)C1 CN(C(=O)C(=O)C1=CC=C(Cl)S1)[C@H1]2CC[C@@H1](NC(=O)C=3SN=NC=3C4CC4)CC2 COC(=O)[C@H1](CC(C)C)NC(=O)[C@H1](C1=CC=CO1)N2CC[C@@H1]([S@](C)(=N)=O)C2 CCN1C(C(=O)N[C@@H1]2CCCN(C(=O)C[C@@H1]3CC3(Cl)Cl)CC2)=CC4=CC=CC=C41 CC(=O)N[C@@H1]1CCC[C@@H1](N(C)C(=O)CC2(C3=C(Cl)C=CC=C3Cl)CCCC2)C1 COCC1=CC(C(=O)NC2=CC=CC(NC(=O)C=3C=NSN=3)=C2)=CS1 CC[C@@H1](C)NC(=O)CCN=C1N=C(N2CCOCC3(CC3)C2)C4=NC=CC=C4[NH1]1 CN1C=C([C@H1](O)C(=O)N2C[C@@H1]3C(CNC(=O)C[C@H1](O)C4=CC=CC=C4)[C@H1]3C2)C=N1 CCC=C(F)C(=O)NCC1=NC=CC=C1C(=O)N(C)[C@@H1]2CCC[C@@H1](C)C2 CC1=CC=C(NC(=O)[C@@H1]2C[C@H1](O)CCN2C(=O)C3CC4(CCOCC4)C3)C=N1 CC(=O)N1CSC[C@@H1]1C(=O)NC[C@@](C)(O)CNC(=O)CCC2=CN=C(C)S2 CO[C@@H1](CC(C)C)C(=O)N[C@H1]1CC[C@H1](NC(=O)C2=CC=CC(Cl)=C2N)CC1 CCN(CCNC(=O)C1=CC=C(C#N)[NH1]1)C(=O)C2=CC=C3C(=C2)COCCN3 O=C(NCC1=NC=CC=N1)N[C@@H1]2C[C@@H1]3CCCCN3C2=O C=C[C@H1]1OCC[C@@H1]1C(=O)NCC2=CC(C(=O)N[C@H1](C)C3CSC3)=N[NH1]2 CC(C)(C)O[C@H1]1C[C@H1](OC(=O)CSC2=NN=C(C3=CC4=CC=CC=C4O3)O2)C1 CCC=C(C)C(=O)NCCN1C=C(C(=O)N[C@H1]2CCNC2=O)N=N1 OC[C@H1](CNC1=NC(N2CCC3=NC=CN=C3C2)=NC=4SC=CC1=4)CC=5C=COC=5 CC(C)(C)C[C@@H1]1CN(C(=O)C2=CSN=C2Cl)C[C@H1]1NC(=O)C3=CC=C(C#N)S3 CC1=C(C(=O)N2C[C@@H1](O)C[C@H1]2C(=O)NCCC3=CCCCC3)OC4=CC=CC=C14 CC(C)(CNC(=O)[C@@H1]1CCCN(CC(F)(F)F)C1)NC(=O)C2CC(C)(O)C2 CCOC1(C(=O)N2CC(N(C)C(=O)C=3N=C[NH1]C4=NC=CC=34)C2)CCC1 C[C@H1](NC(=O)CCOCC(F)(F)F)[C@]1(O)CCN(C(=O)C[C@H1]2CCCS2(=O)=O)C1 CC1=CC=C(F)C(CN=C2[NH1]C(N(C)CC(C)C)=NC3=CC=CC=C23)=C1 CC(C)OC1=CC=C(C(=O)N2CCCC[C@@H1]2CN(C)C(=O)[C@@H1]3CCCSC3)N=N1 CC1=CC(NC2CCN(C(=O)C3=CC4=C([NH1]3)CCC4)CC2)=C(C#N)C=C1[N+1](=O)[O-1] CC=C(F)C(=O)N1CC([C@@H1](C)NC(=O)C2=CC(C3=C(Cl)C=NN3C)=NO2)C1 CCN(CCNC(=O)C[C@]1(O)CCCN(C(C)=O)C1)C(=O)[C@H1]2CCC(=O)NC2 CN1CC[C@@H1](CN(C)C(=O)[C@@H1]2[C@H1]3CN(C(=O)C4(O)CCOCC4)C[C@H1]32)C1 O=C(C1=NC=CC=N1)N2CCN(C(=O)CCCC=3C=CSC=3)[C@@H1](CC(F)(F)F)C2 C[C@H1](OC(F)F)C(=O)N1CCN(C(=O)OC(C)(C)C)C[C@@H1]1C2=CC=C(F)C(F)=C2 O=C([C@H1]1C[C@H1]1F)N2CC[C@H1](N(CCO)C(=O)C=CC3=CC=C(Cl)C=C3)C2 CC(C)CCCCC(=O)NC1(C2=CN(C3=CC=NC(Cl)=C3)N=N2)CC(F)(F)C1 CCC[C@](C)(O)C(=O)N[C@H1](C)CNC(=O)[C@@H1]1C[C@@H1]1F C=CCCC(=O)NC[C@@H1]1COCCN1C(=O)[C@@H1](C(=O)OCC)C(C)(C)C CC[C@@H1](CC(=O)N1CC(O)([C@@H1](C)NC(=O)[C@H1]2CC[C@@](C)(F)CC2)C1)C(C)C C[C@]1(C(=O)NOC[C@@H1]2CCOC2)C=CCN1C(=O)C[C@H1]3CCCCO3 O=C(CC=1C=CON=1)N[C@H1]2CC[C@H1]3C[C@H1]2CN3C(=O)[C@H1]4CC5=NC=CN5C4 CCN1N=NC(C)=C1CN=C2[NH1]C3=C(C(=NC[C@@H1]4CCSC4)[NH1]2)CSC3 CC[C@@H1](CC(=O)N[C@H1](C)CCCNC(=O)CCC1=NC=CN1CC)C2CC2 CC[C@H1](C)CCC(=O)N[C@@H1]1CC[C@]2(CCN(C(=O)CN3N=CC=CC3=O)C2)C1 CC=C1C(CNC(=O)C2=N[NH1]C=CC(C(=O)NC3=NN=C(C4CC4)O3)=CC=C2)=NO1 CCCC[C@@H1](CO)NC(=O)[C@@H1]1C[C@@H1](C)CN1C(=O)C2=CC=C(OCC)N=C2 CCC1=CN=C(Cl)N=C1N2CCC[C@@]3(CCN(C(=O)[C@H1](CC)NC(C)=O)C3)C2 C=CCC[C@@](C)(NCC1=CC=CC(F)=C1)C2=NN=NN2C3=CC=C(F)C=C3 O=C(NC1CC(NC(=O)C2CCC3(CC2)N=N3)C1)C4=CSC([N+1](=O)[O-1])=C4 C=CC[C@@H1](C)C(=O)N[C@@]12CC[C@@](CNC(=O)C3=COC(Br)=C3)(C1)OC2 C[C@H1](NC(=O)C[C@H1]1CCC[C@@H1]1NC(=O)CN2C[C@H1]3C[C@H1]3C2)C4=CC=CS4 C[C@@H1]1NCC[C@H1]1C(=O)NCC2CC3(CCO3)C2 CCCC1=NC=C(NC(=O)[C@@]2(NC(=O)C(CCC)CCC)C[C@H1]2C)C=N1 CNC(=O)[C@@H1]1[C@H1]2CN([C@H1](C(=O)NC(C)C)[C@H1](CC3=CC=CC=C3)CC(C)(C)C)C[C@H1]21 CC1=C(C(N)=O)C=CC=C1C(=O)N(C)CC(C)(C)NC(=O)C2=CSC(Cl)=N2 CC(C)OCC(=O)N[C@H1]1CCN(C(=O)[C@@H1](C)N=C2C=C[NH1]C=C2)C13CCC3 CCCC[C@H1](C)C(=O)N1CC[C@@H1](NC(=O)C=C(C)C=2C=CSC=2)[C@H1](F)C1 CCC[C@@]1(NC(=O)[C@@H1](O)C(C)(C)C)CCCN(C(=O)C23CC(C)(C2)O[C@@H1]3C)C1 COCCC1(NC(=O)[C@@]23C[C@H1]2CCN3C(=O)C4=CSC=C4Cl)CCC1 CC(C)CC(CC(C)C)C(=O)N[C@@H1]1C[C@H1]2CN(C(=O)C3=NC=CN3C(C)C)C[C@@H1]21 CC1=CC=CN=C1C(=O)N2C[C@@H1](C)N(C(=O)C3=CC(F)=N[NH1]3)C[C@H1]2C CNC=1SN=C(C)C=1C(=O)N[C@H1](CCN(C)C(=O)CC[C@@H1]2CCOC2)C(C)C CC(C)[C@H1](NC(N)=O)C(=O)N1CC[C@@H1](CCC(=O)NC[C@H1](C)N2C=CC=N2)C1 O=C(CC(F)(F)C1=CC=CC=N1)N[C@H1]2[C@@H1]3C[C@H1]2N(C(=O)C=CC4=CN=CS4)C3 COCC(C)(C)C(=O)NC[C@H1](O)CC(=O)NC[C@H1]1C[C@@H1]1C=2C=COC=2 C=CCC1(C(=O)NCC[C@@H1](CC2=CC=CC=C2)NC(=O)C[C@@H1](C)C(F)F)CCC1 CC(C)[C@H1](NC(=O)[C@H1]1CCN(C(=O)C=2SC=CC=2I)C[C@@H1]1O)C3=CC=CN=C3 CC1=CC=CC=2[NH1]C=C(C(=O)N3CC[C@@H1](CC(=O)N4CC[C@@](C)(CO)C4)C3)C1=2 CO[C@@](C)(CO)CNC(=O)[C@H1]1CCCN(C(=O)C=2C=CSC=2Cl)CC1 COC[C@]1(CNC(=O)CCCC2=CC=NC=C2)CCN(C(=O)CC=3C=NOC=3)C1 COC(C)(C)[C@H1]1CCCN1C(=O)NCC2COCCO2 C=C1CC(CC(=O)N2CCC3(CC2)C[C@@H1]3CNC(=O)C4(C(=O)NC)CC4)C1 CCC=1ON=C(C(=O)N[C@@H1]2CCN(C(=O)[C@@]3(C)CCC(F)(F)C3)C[C@@H1]2C)C=1C C#CC[C@H1](CC(F)F)C(=O)N1C[C@H1](CCC)[C@H1](NC(=O)[C@H1]2CCCC(=O)N2)C1 O=C(N[C@H1]1C[C@H1](CNC(=O)[C@H1]2CCC=CCCC2)C1)C3=CC=C(Br)C=C3O CC[C@H1](C(=O)N1CCC(O)(CCNC(=O)CCCC2=CC(C)=NO2)CC1)C(C)C CCN(CCC(=O)OC)C(=O)[C@@H1]1CCN(C(=O)[C@H1]2C[C@@]2(C)C(F)F)C1 COCC[C@@H1]1C[C@H1]1C(=O)N(C)[C@H1](CNC(=O)[C@@H1](O)CC2=CN=C[NH1]2)C3CC3 CCC1=CC(CN[C@H1]2CCCC3=C2C=NN3CCO)=N[NH1]1 CC[C@@H1](O)CNC(=O)[C@H1]1CC[C@@H1](C)N(C(=O)[C@H1]2[C@H1]3CC[C@@H1](C3)[C@@H1]2C)C1 C=CCN1N=NN=C1[C@@H1](N[C@H1]2CCCC[C@@H1]2OC)C3=CN=C(C4=CC=CO4)S3 C[C@@H1](CC(=O)N[C@H1]1CCCN(C(=O)CC2=CC(C(F)(F)F)=N[NH1]2)C1)C3=CC=CO3 COC1=CC=C(C(=O)N2C[C@H1](C)CN(C(=O)COC=3C=CSC=3)[C@H1](C)C2)C=C1N O=C(C#C[C@@H1]1CCCOC1)NCC2(NC(=O)C3=CC=C(Cl)C(Cl)=C3)CCC2 CCO[P@](C)(=O)CCNC(=O)NCC1=CC=CC(NC(=O)[C@@H1]2CCCO2)=C1 CN(CC(C)(C)NC(=O)[C@@H1]1C[C@@H1]1F)C(=O)CSC2=CC=C3C4=C(C=CC=C24)CC3 COC(=O)C1CCN(CC2=CC=C(OCC(=O)O)C=C2)CC1 CC(C)N(CCN(C)C(=O)C1=NOC=C1Cl)C(=O)C=2C=C[NH1]C3=NC=CC=23 CCCC[C@H1]1CN(C(=O)C2(S(N)(=O)=O)CCC2)CCN1C(=O)[C@H1]3CC(C)=NO3 C=CCC1(C(=O)N2CC3(C[C@H1](NC(=O)C=4SC(F)=CC=4Br)CO3)C2)CCC1 CC1=CC=C(S(N)(=O)=O)C=C1C(=O)NC[C@@H1]2C[C@H1]3CC[C@H1]2N(C(=O)[C@H1]4C[C@@H1]4C)C3 C#CCCN(CC)C(=O)C[C@H1](C)C(C)(C)NC(=O)CCCCC(N)=O O=C(N[C@@H1]1CN(C(=O)C2=CC=C3C(=C2)OCCO3)C[C@H1]1O)[C@H1](O)C4CCOCC4 CC[C@@H1](O)C(=O)NC[C@H1]1CN(C(=O)C2=CC=CC(F)=C2O)CCC1(C)C CCCC1=NC(C)=C(C(=O)N[C@@H1]2CCN(C(=O)[C@H1](C)NC(=O)OC)C2(C)C)S1 CC(C)[C@H1](C(=O)N1CCN(C(=O)C2=CC=C3C(=C2)CC3)C[C@H1](C)C1)N4C=NN=C4 C[C@H1](CNC(=O)[C@@H1]1CNC[C@H1]1S(C)(=O)=O)CNC(=O)OC(C)(C)C N#CC1=CC=CC(NC(=O)[C@@H1]2CCCN(C(=O)C3=CC=C([N+1](=O)[O-1])O3)C2)=C1 CN1N=CC=C1[C@@H1]2C[C@H1]2C(=O)NC3CC4(C3)CC(NC(=O)[C@@H1]5CCCCNC5=O)C4 COC1=NC=C(C(=O)NCC[C@H1]2CCN(C(=O)CCC3=CN=C(O)[NH1]3)C2)C=N1 C[C@@](O)(C(=O)N[C@@H1]1CC[C@H1]1NC(=O)C2=CC=C(CN3CCCC3)C=C2)C4CCC4 CC=1C=C(C(=O)NCCCCCCNC(=O)C2=C(C)C=CC(C)=C2C)ON=1 C=CCC1(NC(=O)[C@H1](C)O)CN(C(=O)C=2N=NN(CC3CCCC3)C=2C)C1 O=C(C=CCF)NC[C@@H1]1CCC[C@@H1]2CN(C(=O)CSC3=NN=CS3)C[C@@H1]21 C[C@]1(C#CC(=O)N[C@H1]2C[C@@H1](C(=O)NCCC3=CSN=N3)C2(C)C)CCCO1 CN1CCN([C@H1](CNC(=O)C2=CC=C(CN3CCN(C)CC3)S2)C(C)(C)C)CC1 CCC[C@H1](C)N(C)CCC(=O)NC1(CO)CN(C(=O)C2=CC(=O)C=C(Cl)[NH1]2)C1 CCN(C)[C@H1]1C[C@@H1](C(=O)N2CCC3(CC3)C[C@@H1]2C(=O)N4CC=C[C@@H1]4COC)C1 CC(C)C1=N[NH1]C=C1C(=O)N[C@H1]2C[C@@](C)(NC(=O)COC3=CC=C(Cl)C=C3)C2 CC[C@@H1](O)[C@@H1](C)C(=O)NCC=1C=C2N(N=1)CCN(C(=O)CCCOC(C)C)C2 C#CC1=CC=C(C(=O)N2C[C@H1]3CN(C(=O)C=CCCC)C[C@H1]3C2)C(F)=C1Cl COC[C@H1](C)CC(=O)NC[C@@]1(NC(=O)[C@H1]2C[C@H1](SC)C2)CC3CCC1CC3 CCC[C@@H1]1CCCN1S(=O)(=O)C2=CC=C(NC[C@](C)(CC)OC)C(Br)=C2 C[C@@H1](CCNCCC1=CC=C(Cl)S1)C2=CC=CC=C2 CC=1N=C[NH1]C=1C(=O)N2CC(O)(C3(CNC(=O)[C@@H1](C)[C@@H1]4CCC(=O)N4C)CC3)C2 COC(=O)[C@@H1]1COC(C)(C)CN1C(=O)C=2C=C(I)N(C)N=2 CN(C)CC(=O)NC[C@@H1]1C[C@@H1](NC(=O)/C=C/C2=CC(Cl)=CC(Cl)=C2)CCO1 O=C(N[C@]1(CNC(=O)[C@H1]2C[C@H1]2F)CCOC1)C3=CN4C=CSC4=N3 CC(C)(CNC(=O)[C@H1]1CCCS1)[C@@H1]2CCCN2C(=O)C3=CC(F)=CC(F)=C3O C=CC[C@@H1](C)C(=O)N1C[C@@H1](O)C[C@H1](NC(=O)C(C)(C)O)C1 CC1=NC(=N)[NH1]C=C1C(=O)N2CCC[C@@H1](N(C)C(=O)[C@@H1]3CCN(C)C3=O)C2 C=C=CCCC(=O)N1CC2(C1)CN(C(=O)CC3=CC=C(Br)C=C3)C[C@H1]2CO C[C@@H1](CCC(=O)N1CC[S@](=O)C[C@H1]1CO)NC(=O)C2=C[NH1]C(=N)O2 C#CCCCCC(=O)NC[C@@H1]1CCC[C@H1]1NC(=O)[C@@H1]2[C@@H1](C(=O)OC)C2(F)F CC1=NC=C(C(=O)N(C)CCCCN(C)C(=O)[C@H1]2CCCC23CCC3)C=N1 CNC(=O)NCC(=O)N(C)C1CCN(C(=O)[C@H1](O)CC2=CN=C[NH1]2)CC1 C#CC[C@@H1](C(=O)NC[C@](C)(NC(=O)C1=CC=C2C(=C1)CC2)C3CC3)C4CC4 C[C@@H1](O)C(=O)NC[C@@H1]1C[C@H1](C)CCN1C(=O)C[C@@H1]2C[C@@H1]3C=C[C@H1]2CC3 COCCCCCC(=O)N[C@H1](CCOCCO)C(=O)NCC1=NC=CC=C1F CCOC1=CC=NC(NC[C@@H1]2C[C@@H1](C)N(C(=O)[C@H1](C)CCCOC)C2)=N1 CSC1=NC=CC(=NC2C[C@@H1]3CCC[C@H1](C2)N3S(=O)(=O)C4=CC=C(Br)C=N4)[NH1]1 CCN1C(C(=O)N2CCC[C@@]3(C[C@@H1](NC(=O)C4CC(Cl)(Cl)C4)CO3)C2)=CN=C1O CCC[C@@H1](C)C(=O)N[C@H1](C)CCCCNC(=O)C1=CC=2C=CSC=2N1C CCN1C=NC(C(=O)NC[C@@](C)C2N(C(=O)[C@H1]3C[C@H1]3C(=O)NCCO)C(C)(C)C2)=N1 O=C1CCCC[C@H1]1OCC(=O)N2CCC23CN(C(=O)C4=C(F)C=C(F)C=C4F)C3 CC(C)N1C[C@H1](C(=O)N2CC[C@@H1](CNC(=O)[C@H1]3CCCN(C(C)C)C3)C2)CC1=O CCN(CCC(=O)N(C)C[C@@H1]1CC1(C)C)C(=O)CCCC(C)(C)C CCC[C@](C)(O)CC(=O)N1CCC[C@H1]1C2(NC(=O)C3=CC=CC(O)=N3)CC2 CCC=CC(=O)N1CCO[C@@H1]2CN(C(=O)C3=CC(OC)=CC=C3O)C[C@@H1]21 CCOC1=CC=CC([C@H1](C(=O)NC2CC2)N3CC[C@H1](OCC4=CN=CS4)C3)=C1O CCC=1N=NSC=1C(=O)N[C@@H1]2C[C@@H1]2CNC(=O)CCN3CCOC3=O CC=1OC(C#N)=CC=1C(=O)NC[C@H1](CNC(=O)CC2=CN=CC=C2Cl)C(F)(F)F CN(C(=O)[C@@H1]1CNC(=O)CC12CCC2)C3CCN(C(=O)C4=CC=CN=C4S)CC3 CC1(NC(=O)[C@H1]2CN3CCC[C@H1]3CO2)CN(C(=O)CCCC4=CSC(=N)[NH1]4)C1 CO[C@H1]1C[C@@H1](CCNC(=O)[C@H1](CO)C2=CC=CC=C2)N(C(=O)CN3C=NN=N3)C1 CN1C=C([C@@H1](O)C(=O)NC[C@H1](O)CNC(=O)CS(=O)(=O)N(C)C)C=N1 CCC1=NOC([C@H1](C)OC(=O)C2=CC=C(C3CCN(C(=O)C(C)=O)CC3)O2)=N1 C[C@H1](O)C(F)(F)C(=O)N1CC([C@@H1]2CCCCN(C(=O)[C@@]34CC=C[C@@H1](C3)OC4)C2)C1 C[C@H1](O)[C@@H1](C(=O)NCCN(C(=O)C[C@@H1]1CC2=CC=CC=C2N1)C3CC3)N(C)C CC[C@H1](C)[C@H1](O)C(=O)N1CCOC[C@@H1](CNC(=O)C(C)(C)NS(C)(=O)=O)C1 CN(C(=O)[C@H1]1CC1(C)C)[C@@H1]2CN(C(=O)C3=CN=C(Br)C(O)=C3)C[C@H1]2O CC1(C)CCC[C@@H1](C(=O)OCC(=O)NC2=CC=C(Br)C=C2Br)C1 N[C@H1](CCNCC1=CC=C(CN2C=CC=N2)C=C1)C3CC3 COC1=CC(CN2CC3(C[C@H1]3C(=O)N4CC[C@@H1](OC)C4)C2)=CC=C1Br CCCN(C)CC(=O)N(C)CCOCCCN(C)C(=O)CN=S(C)(=O)OCC CCCC(CCC)CC(=O)NC[C@]1(F)C[C@@H1](CNC(=O)[C@H1](C)OCCOCC)C1 CN(C)CCC(=O)N1CC2=N[NH1]C=C2[C@@H1]1C(=O)N3CC[C@H1](N4C=CN=C4)C3 CC(C)C1=NO[C@H1](C(=O)NC2=CC=CC(N(C)C3=CC=CC=C3)=C2)C1 CC1=NC=C(C(=O)NC[C@@H1](F)CNC(=O)CC2=N[NH1]C3=C2CCCC3)C(=N)[NH1]1 COC(=O)C1(C(=O)N2CC[C@@H1](C(C)(C)NC(=O)C=3OC=CC(=O)C=3OC)C2)CC1 CC1=CC=C(C(F)(F)C(=O)N2CC[C@H1]2CNC(=O)[C@H1](O)CC(C)C)C=C1 C[C@@H1](CCCNC(=O)[C@]1(F)CC12CCCCC2)NC(=O)C3=CC(=O)N(C)O3 CN1N=C(O)C2=C1CN([C@H1](C(=O)NC3CCOCC3)C4=CC(Cl)=CC(Cl)=N4)CC2 CC(Cl)=CC(=O)N1CC[C@H1](CNC(=O)C[C@@H1]2CS(=O)(=O)CCN2C)C(F)(F)CC1 C#CC1=CC=C(C(=O)N[C@@H1](CNC(=O)C2(C=C)CC2)C3=CC=CC=C3)C=C1 CNC(=O)[C@@H1](NC(=O)[C@@H1]1CCN(C(=O)C2=CC=C(SCCCO)C=C2)[C@H1]1C)COC CN=C1[NH1]C(=NCC2=CC(C)=CC(F)=C2)[NH1]C(=NC[C@@H1](OC)C3=CC=CC=C3)[NH1]1 COC[C@]1(C)COCCN1C(=O)C2=CN=C(Br)C(OC)=C2 CC1=CC=CC(C(=O)NCCOC2CN(C(=O)CN3C=CSC3=N)C2)=N1 CC(C)C[C@H1](CNC(=O)C[C@@H1]1CCCC[C@H1]1O)NC(=O)[C@H1]2[C@@H1](C)[C@H1]2C C[C@H1](CCCC(=O)N[C@@H1]1C[C@H1]2C[C@H1]1[C@@H1](O)[C@@H1]2O)NC(=O)[C@H1](O)CC3CCCC3 CCSCCC(=O)N[C@H1]1C[C@@H1]1NC(=O)COC[C@@H1]2CCCCO2 CC(C)[C@@H1]1CN(C(=O)[C@H1]2C[C@H1](NS(=O)(=O)C3=CC=NC=C3)C[C@H1]2C)CCO1 C=C[C@@H1]1COC[C@@H1]1NC(=O)[C@@H1](CCC)NC(=O)[C@@H1](F)CC(C)(C)C COC=NC=CC(=O)N[C@H1](C(=O)N1CC[C@](C)(O)C1)C2CCC2 CC1(C(=O)NC[C@](C)(CC(C)C)NC(=O)[C@@H1]2CCCC3=CC(O)=CC=C32)COC1 C#CC1=C[NH1]N=C1C(=O)NC(C)(C)[C@H1]2CCN(C(=O)[C@@H1](C)C3=CCCC3)C2 C[C@@H1]1CC[C@H1](CC(=O)N2CC(C3(NC(=O)C4=CC=NS4)CC3)C2)C1 COC(=O)[C@@H1]1CC2=CC=CC=C2[C@@H1]1NC(=O)C3=N[NH1]C=C3C(=O)OC(C)(C)C CCOC(=O)N[C@@H1](C(=O)N(C)CC1=CC=CC2=CC=CC=C12)C(C)C CC[C@H1](C)[C@H1](OC)C(=O)N1C[C@@H1](NC2=NC=NC=3[NH1]C=NC2=3)CC(C)(C)C1 COC1CN(CCNC(=O)[C@H1]2C[C@@H1](NC(=O)C[C@@H1]3CC[C@@H1](C)O3)C2)C1 CN(C(=O)[C@@H1]1CCC2(CC2)N1C(=O)CNC(=O)C(C)(C)C)[C@@H1]3CC3(C)C C=C[C@H1](C)CC(=O)N1C[C@@H1](NC(=O)CCCOC2CCOCC2)CC1(CC)CC CC[C@H1](CC1=CC=CC=C1)C(=O)NC[C@H1](C)NC(=O)[C@H1]2CCC3=CC=CC=C32 C[C@H1](C(=O)N1C[C@H1]2CCN(C(=O)C3CN(S(C)(=O)=O)C3)CC[C@H1]2C1)S(N)(=O)=O CC1=NC(CCCC(=O)N[C@]23CCC[C@@H1]2CN(C(=O)CC(C(C)C)C(C)C)C3)=N[NH1]1 CCOC1=CC(C(=O)N[C@@H1]2C[C@H1](C)N(C3=NC(CC)=NC=C3C#N)C2)=CC=N1 COC[C@@]1(C)COCCN1[C@H1](C(=O)NCCCF)C2=CC=CN(C)C2=O CC1=CC=NC(O)=C1C(=O)N[C@H1]2CCC[C@H1](NC(=O)CC3=C(F)C=CC=C3Cl)C2 C[Si]1(C)CC[C@H1](CN=C2[NH1][NH1]C3=CC(C#N)=CC=C23)C1 CC[C@@H1](CNC(=O)C1CC(CCNC(=O)C2(CC)CC(C)(C)C2)C1)C(C)(F)F CCN1CC[C@@H1](CNC(=O)[C@@H1](C)NC(=O)C2(C#N)CC2)C1 CC(=O)OCCCN(C)[C@H1](C)C(=O)NC1=CC=C(S(=O)(=O)NC2CC2)C=C1 CCC[C@H1]1COCCN1C(=O)C[C@H1](NC(=O)[C@@H1](C)CN2C=NC=N2)C(F)F O=C(NC[C@@H1](O)C1CC1)[C@H1](CC2=CN=C[NH1]2)NC(=O)[C@@H1]3CCC[C@H1](CF)C3 C=CCCC[C@@H1](NC(=O)[C@@H1](C)CC(C)C)C(=O)NC1=CN=CC=C1CO CCN1N=CC(C(=O)N[C@@H1]2C[C@@H1]3CN(C(=O)[C@@H1]4CC[C@@H1]5CCCCN54)C[C@H1]32)=C1C O=C(NCCCCO)[C@@H1]1C[C@H1](O)CCN1C(=O)[C@H1]2C[C@H1](O)[C@@H1](F)C2 C[C@H1]([C@H1](O)C1=CC=C(F)C=C1)N(C=O)CC2=CC=C(F)C(Br)=C2Cl CCC[C@@H1]1C[C@H1]1C2=CSC(N(CC3=CC=CC=C3)[C@@H1](C)CC)=N2 COC(=O)[C@H1]1CC[C@@]1(C)C(=O)NCC[C@@H1](C)NC(=O)C2=C[NH1]C(C(F)(F)F)=C2 CC1=CSC(=O)N1CC(=O)NC[C@@H1]2CCCN(C(=O)[C@@H1]3CN4CCN3[C@@H1](C)C4)C2 CCCO[C@@H1]1CCCN(C(=O)C[C@@H1]2N(C(=O)C[C@H1]3CNC(=O)O3)CCC2(C)C)C1 CC(C)[C@H1](CNC(=O)C1=CN2N=CC=CC2=N1)NC(=O)CN3[NH1]C=NC3=N CC1=NC(C(=O)C(=O)N2CC[C@H1](C)[C@@H1](NC(=O)C=CCO)[C@H1]2C)=CS1 CCCC[C@H1](O)C(=O)N[C@@H1]1CN(C(=O)C2=CN(C)N=C2CC)CC3(CC3)C1 CC(C)(C)OC(=O)N[C@@H1](CNCC1=NC=CC(Cl)=C1Cl)[C@@H1]2CCOC2 COC1=CC=CC=C1OCCNC(=O)C2=NC3=CC=C(C4=CC=NN=C4)C=C3O2 C[C@@H1](CC1=CC=C(F)C=C1F)C(=O)N[C@H1]2C[C@H1](CNC(=O)CCC=3C=N[NH1]C=3)C2 C[C@H1](NC(=O)CN1C=C(C2CC2)N=N1)[C@H1](C)NC(=O)C34CCCN(CCC3)C4 CC1=CC(C(=O)NCC2(O)CN(C(=O)[C@H1](C)C/C=C/C3=CC=CC=C3)C2)=NO1 CC(C)[C@H1](CCN(C)C(=O)[C@@H1]1CC(=O)N(C)C1)NC(=O)CC2=CN=CN2C CC(C)OCCC(=O)N(C)CCOCCCNC(=O)[C@@H1]1CCC[C@@H1]1N2C=CC=C2 CCCC1(C(=O)N(CCNC(=O)CC2(N3C=CN=C3)CC2)CCOC)CCC1 COC1=CC=CC([C@@H1](C)C(=O)N2CCCO[C@H1](CN=C3[NH1]N=C(C)O3)C2)=C1 C[C@@H1](CNC(=O)OC(C)(C)C)CS(=O)(=O)NC1=CN=C(C2CC2)N=C1O CC1=NOC2=NC=C(C(=O)N[C@]3(C)C[C@H1](NC(=O)C=CC4=CN=CS4)C3)C=C12 COC(=O)C1=NSC(=N[C@H1]2C[C@H1](CNC(=O)[C@H1](F)[C@@H1](C)C(F)(F)F)C2)[NH1]1 CN1N=CC(Cl)=C1NC(=O)[C@H1]2[C@H1]3CN(C(=O)CC4=CC=C(Br)C=N4)C[C@H1]32 CCC=1ON=C(C(=O)N[C@H1]2C[C@H1](OC)C23CCN(C(=O)C=C(C)Cl)CC3)C=1C CC=1N=C(C(C)C)SC=1C(=O)N(CCNC(=O)C=2C=CN(C)C=2)CC3CC3 CC1=CC=CC(O[C@H1]C2CC[C@@](C(=O)O)(C(F)(F)F)CC2)=C1C(=O)O CC[C@H1](CNC(=O)C1=CN=C(C2CC2)N=C1O)NC(=O)[C@H1]3CCCCN(C)C3=O COC(=O)C1=CC=C(C(=O)COC(=O)CCC(=O)C2=CC=CC=C2N)C(C)=C1 CC(=O)N1CC(C(=O)NC[C@@H1]2C[C@H1](C)N(C(=O)C3=CC4=CC(C)=CC=C4[NH1]3)C2)C1 CCC1=NC=C(C(=O)N2C[C@H1](CNC(=O)[C@@H1]3CC3(F)F)CC24CCC4)S1 C[C@@H1](CNC(=O)CC12CC(C1)C2)NC(=O)C3=CC=C(C(F)F)S3 C[C@]1(C(=O)N2CCCC[C@@H1](C(=O)N[C@@H1]3CCCC[C@H1]3F)C2)CNC(=O)C1 CC=1[NH1]C(C(=O)N2CC[C@H1](C)[C@H1](NC(=O)[C@H1]3C[C@H1]3C4CCCC4)C2)=C(C)C=1C CCOCCNC(=O)C1C[C@@H1]2CC[C@H1](C1)N2C(=O)C3=COC(SC)=C3 CC(C)(C)[C@H1]1CCC[C@@H1](C(=O)N[C@H1]2C[C@H1]2F)N1C(=O)C3=CC=CC=C3C=O COC(=O)C1=NC=C(C(=O)N[C@@H1](C)[C@H1](C)NC(=O)C2=NC=CN3C=CN=C23)S1 CC1=CC(C(=O)N[C@@H1]2CCC[C@H1]2NC(=O)[C@@H1]3CC[C@H1]4C[C@@H1]3CO4)=C(S(N)(=O)=O)S1 CC1=CC(C)=CC(C=CC(=O)N[C@](C)(CNC(=O)[C@@H1](CO)N(C)C)C2CCC2)=C1 O=C(NC[C@@H1]1[C@@H1]2CC3=CC=CC=C3[C@H1]12)N(CCCO)C4CCCCC4 C=CC[C@H1](CC)C(=O)NCCOCCC(=O)N1CC[C@@H1](C(N)=O)C1 COC(=O)C1=CC=C(C(=O)N2C[C@H1](CNC(=O)C=3SC=CC=3F)CC(C)(C)C2)O1 O=C(N[C@H1]1CC12CC(NC(=O)C3=CC4=CC(F)=CC=C4S3)C2)C=5C=N[NH1]C=5 CO[C@@H1]1C[C@@H1](CNC(=O)[C@H1]2CC2(Cl)Cl)N(C(=O)C3(O)CCCCC3)C1 C[C@H1]1C[C@@H1]1CN(C)C(=O)CSCCNC(=O)CN(C)C2CCC2 O=C(NC1=CC=CC(C2=CC=NC=C2F)=N1)C3=CC=C(CO)O3 C#CCC[C@@H1]1CCCN(C(=O)[C@H1]2CCN(C(=O)[C@H1](COC)OC)C[C@H1]2C)C1 C[C@@H1]1[C@@H1](NC(=O)C=2C=CN(C)C=2C3=CC=CC=C3)CCCN1C(=O)CCCF CC1=NN(C)C=C1[C@H1]2NC(=O)CCN(C[C@@]3(F)OC(=O)CC34CCCC4)C2=O CCOC(=O)C1=CN=C(N2CC[C@@H1]2CNC(=O)C3=CC=NC=C3C)S1 CC[C@@H1]1C[C@H1](C)CN([C@H1](C(=O)N[C@@H1](C)CC)C2=NC=C(C(F)(F)F)[NH1]2)C1 CC[C@@H1](O)CCCN(C)C(=O)CC[C@@H1](C)NC(=O)C1(N(C)C)CC1 CN1CCOC[C@H1]1C(=O)N(C)[C@H1](CNC2=NC=NC(O)=C2Br)C3CC3 CCN1C=NC(C(=O)N2CC3(CC(CNC(=O)[C@@H1]4C[C@@H1]4C=5N=C[NH1]N=5)C3)C2)=C1 CCOC1=NC=C(C(=O)N[C@@H1](C)CNC(=O)C=CC2=CC=NC=C2)C=N1 CC1(C)CCO[C@H1]1CCN=C2N=C3SC=NC3=C(N[C@H1]4C[C@@H1](S(C)(=O)=O)C4)[NH1]2 CN(C)[C@@H1]1CC[C@H1](C(=O)N2C[C@@H1](F)C[C@H1]2CNC(=O)C=3C=NN(C)C=3C(F)F)C1 C=C(Br)CNC(=O)[C@H1]1CN(C(=O)CC[C@H1]2CCC(=O)C2)CC1(F)F CC1(CCC(=O)N2CCO[C@H1]3COC[C@H1]32)CN(C(=O)C4CC(F)(CF)C4)C1 CC(C)CCC=1N=C(C2=CC=C(F)C3=C2OCC3)N(CC4CCC4)N=1 CC=1C=C(C(=O)N[C@@](C)(CNC(=O)[C@H1]2CCCN2C)CC(C)C)OC=1C C[C@@H1](NC(=O)CCCCN1C=CC=C1)[C@H1]2CN(C(=O)COCC(C)(C)C)CCO2 CCCCC[C@@H1](C(=O)NC[C@@H1]1CCN1C(=O)C[C@H1]2CCCCO2)C(C)C C=CCCC[C@@H1](NC(=O)CC[C@@H1](CC)OC)C(=O)NCC1=NC=CN1CC CC1(C=2C=C(C(=O)NC3(CCNC(=O)C4=COCCC4)CCC3)[NH1]N=2)CC1 CC(C)(NC(=O)[C@@H1]1CCC2(CCC2)C1)[C@H1]3CCN(C(=O)C4=CC=C(CO)C=N4)C3 CCN1CC[C@@H1]1C(=O)NCC2(CN(C)C(=O)C3=C(Br)C=CC(C)=C3F)CC2 CC(C)(O)CC(=O)N[C@@H1]1CN(C(=O)C2=CC=C(Cl)O2)C[C@H1]1O C[C@@H1](C(=O)N[C@H1](C)C1(O)CN(C(=O)C2=CC=C(Cl)N=C2O)C1)C(=O)N3CCOCC3 CSCCCCC(=O)N1CCC[C@H1]1CN(C)C(=O)[C@H1](SC)C(C)(C)C O=C(CCCCCF)N1CCC[C@@H1](N(CCO)C(=O)C=C2CN3CCC2CC3)C1 C[C@H1](CCCO)CNC(=O)[C@@H1](NC(=O)C1=CC=C2C=C[NH1]C2=N1)C3(O)CCC3 CO[C@@H1]1C[C@H1](C(=O)NC2(CF)CC2)N(C(=O)C3=CC(C)=C(C)N=N3)C1 CN(C)C1=CC=C(C2(C(=O)N3CCC[C@@H1](NC(=O)C(F)=CC4CC4)C3)CC2)C=C1 CC=1C=C(C#CC(=O)N2CCO[C@@H1](C(=O)NC[C@H1]3CNC(=O)O3)C2)ON=1 CCCCN(C)C1=NC=NC(NCC[C@@H1]2CCCOC2)=C1C CCC[C@@H1](O)CC(=O)N1C[C@@H1](NC(=O)C[C@@H1](C)O)C2(CCC2)C1 CN1CC(C(=O)N2CC=C(C(C)(C)C(=O)N3CC[C@H1]3C(N)=O)C2)C1 COC1=CC=CN=C1NC(=O)[C@H1]2C[C@@H1](O)CN2CC3=CC(OC)=C(OC)C=C3F CC1=CC=C(N2CC[C@H1](F)[C@H1](NC(=O)C=3C=CC4=NC=CN4C=3)C2)C([N+1](=O)[O-1])=C1 CN1CC[C@](NC(=O)[C@@H1]2CC[C@H1](O)CN2C)(C(=O)NC[C@@]3(O)CCC[C@@H1]3O)C1 CN(CCCNC(=O)[C@]1(Cl)CC1(C)C)C(=O)[C@H1]2CCOC3(CCOCC3)C2 CC=1ON=C(C2CC2)C=1C(=O)N3CC[C@H1]3CNC(=O)C=4C=CSC=4 CCOCCOCCC(=O)N[C@@H1](C)[C@H1]1CCN(C(=O)C2CC2)C1 COC1=CC=CC(C2(C(=O)N[C@H1]3CC[C@H1](NC(=O)C4=N[NH1]C=C4C)CC3)CC2)=C1 O=C(CO[C@H1]1CCOC1)N[C@@H1]2CCCN(C(=O)CCSC3=CC=CC(Cl)=C3)CC2 CCCC(=O)N1CC2(C1)OC3(CO)CC2(NC(=O)C4=CN=C5C(C=NN5C)=C4)C3 C[C@@H1]1C[C@H1](C(=O)NC[C@H1]2C[C@@H1]2CNC(=O)C3=CC4=C([NH1]3)CCOC4)CCO1 CCCNC(=O)[C@H1](C=1C=C(C2=CC=CC=C2)[NH1]N=1)N3CCOCC[C@H1]3C(F)F CC[C@@H1]1CN(CC2=CC=CC(C3=CC(C)=CN=C3Cl)=N2)CCN1C(=O)OC(C)(C)C C#CCCC(=O)NC(C)(C)[C@@H1]1CCCN1C(=O)COC2=CC=C(O)C=C2 CC1=NSC(C(=O)N[C@H1]2C[C@@H1](CNC(=O)COC(F)F)C2(C)C)=C1N CN1CC[C@H1](CC(=O)NCCOCCN(C)C(=O)CN2N=NC(C3CC3)=N2)C1=O CCCC[C@@H1](CO)NC(=O)[C@H1]1COCCN(C(=O)C=2C=C(C)[NH1]N=2)C1 C[C@H1]1CCN(C(=O)C2=CC=NN2C(F)F)C[C@@H1]1NC(=O)CCCS(N)(=O)=O C=CCC(=O)N1C[C@@]2(CNC(=O)CC3=CSC(C4=CC=CC=C4Cl)=N3)C[C@H1]1CO2 C[C@H1]1CC=C(C(=O)NCCOCCOCCNC(=O)CC(F)(F)C(F)F)CC1 C=C(C)COCC(=O)NCC[C@H1](C)N(C)C(=O)CC1=CC(F)=C(N)C=C1F CCCC(CCC)CC(=O)N(C1CC1)[C@@H1](C)C(=O)NCC2=CC(F)=CC=C2O C[C@@H1](CC1CCCCC1)C(=O)N2C[C@@H1](NC(=O)CCC(F)(F)F)[C@H1](C3CC3)C2 O=C(CCCC(F)(F)CO)NC1=CC=C(NC(=O)[C@H1]2CCC3=C[NH1]N=C32)C(O)=C1 CC1=NN(CC(=O)N[C@@H1](C)[C@H1](C)NC(=O)C23CC(C(C)C)(C2)C3)C(C(F)F)=C1Cl CC1=CC=CC2=C1OC[C@H1]2C(=O)N3CC(CNC(=O)C=CC4=CC=NC=N4)C3 C#CCC1CCN(C(=O)NCC2=CC=C3C(=C2)CCCC3)CC1 CC1=CN=C([C@@H1](C)NC(=O)C2=CN(CCNC(=O)C3=CN(C)N=C3C)C=N2)O1 CC1=CC(C(=O)N(C)C[C@H1](C)NC(=O)[C@@H1](C)OC2=CC=CC=C2C(F)(F)F)=N[NH1]1 CCC1=CC=C(C(=O)N2CC(C3(NC(=O)[C@@H1]4CC5=CC=CC=C54)CC3)C2)N=C1 CCCC[C@H1](O)C(=O)N1C[C@@H1]2CCC[C@]2(CNC(=O)C3=C(Cl)CCCC3)C1 C#CC1(C(=O)N[C@H1](CNC(=O)[C@H1](CC)NC(C)=O)C(C)C)CC1 C=CCOCC(=O)NCC(C)(C)CC1CN(C(=O)C2=CC=C(SC)S2)C1 C=CCOCCCC(=O)N[C@@H1](CC)CN(CC)C(=O)C1=CC=CC2=C1N=CN2C COC1=C(C)C=C(Cl)C=C1C(=O)NC[C@H1](C)NC(=O)C2=CC3(CCOCC3)C2 C=CCSCC(=O)NC[C@@H1](CC)NC(=O)C1=CC=C2C(=C1)C(=O)CCCC2 CCC1([C@@H1](NCC=2N=NOC=2C3CC3)C4=NN=NN4CCCOCC5CC5)CC1 CC1=CC([N+1](=O)[O-1])=CN=C1C(=O)N[C@H1]2CC[C@H1](CNC(=O)CCC(F)(F)F)C2 CCCCN(C(=O)N[C@H1]1CCCS(=O)(=O)CC1)[C@@H1]2CCCC[C@@H1]2O CCC[C@H1]1C[C@@H1]1C(=O)N2CCC[C@@H1]2CN(C)C(=O)CCN3CCCC3 CC=1SC(Cl)=NC=1C(=O)N2CCCN(C(=O)CN3CCC[C@@H1]3C)[C@@H1](C)C2 CC1=NC=C(C(=O)N[C@@H1](CNC(=O)CNS(N)(=O)=O)C2CCC2)[NH1]1 O=C([C@@H1]1CCC[C@H1](C2CCC2)O1)N3CC(CCN4C=C(CO)N=N4)C3 COC1=CN=NC=C1C(=O)N2CCN(C(=O)C[C@H1]3C[C@@H1]3C(C)C)C[C@@H1]2CCO O=C(CC1=CSC=N1)NCC2(F)CC(NC(=O)C=3SC([N+1](=O)[O-1])=CC=3Cl)C2 CC1=CC=NN=C1C(=O)N2CC(CNC(=O)C3CC=CC3)(C(C)(C)O)C2 CC(=CC1CCCC1)C(=O)NCCC2CN(C(=O)CC3=NC=C(Cl)S3)C2 CC1=CC=C([C@@H1](C)C(=O)NC2(CO)CN(C(=O)[C@H1]3C[C@]4(COC(=O)N4)C3)C2C)C1 O=C(NC[C@H1]1C[C@H1](NC(=O)C2=C[NH1]C(Br)=C2)C1)C3=C[C@H1]4CCC=CCC[C@H1]34 CC1(C)CCC[C@@H1](CN[C@@](C)(CCC(C)(C)C)C2=NN=NN2C)O1 C[C@H1](C(=O)N1CCN(C2CN(C(=O)[C@@]3(C)CCC(F)(F)C3)C2)CC1)C(C)(F)F C=CCNC(=O)[C@H1](C1=CCCCC1)N(CC)[C@@H1]2CCCSC2 C1[C@@](O)(CNC(=O)[C@@H1]2CNC(=O)N2)CN3C=C(C4=CC=C(N)C(F)=C4)N=C3C1 CN1C(=O)NCC12CN(C(=O)[C@](C3)CCCN(C(=O)[C@@H1]4CC(=O)CC45CCC5)C3)C2 CC=1N=C(S)SC=1CC(=O)N2CC[C@H1]3CC[C@@H1](C2)N3C(=O)C=CC(N)=O CC(C)CC[C@H1](NC(=O)C1=CC=NN1C)C(=O)N(C)[C@H1]2C[C@H1](O)C2(C)C COCCC(=O)N1C[C@@H1](NC(=O)[C@@H1](C)C(C)(C)C)[C@H1](C2=CC=CC=C2)C1 C[C@@H1](CNC(=O)C1(O)CC(CF)C1)NC(=O)CC=2C=NN(C3CC3)C=2 CC1(C)CCN(C(=O)CCC2=CC=CS2)[C@H1]1CNC(=O)[C@@H1]3C[C@@H1]4C=C[C@H1]3CC4 C=C1CC[C@@H1]1C(=O)N2CCC[C@@]2(C)CNC(=O)CCN3C(=O)NC(C)(C)C3=O O=C(CN1C=CC(Br)=N1)NCCC2(NC(=O)[C@@H1]3CCC3(F)F)CCC2 C[C@@H1](CNC(=O)CC1=C(Cl)C=CC=C1Cl)CNC(=O)C(C)(C)OCC(F)(F)F C#CCSCC(=O)N(CC)[C@@H1](C)C(=O)NCC1=CSC(C)=N1 CC(C)(C)[C@@H1](O)CNC(=O)C1(NC(=O)C2=CN=C(O)O2)CSC1 CC1=CC=C2C(C(=O)N(C)CCNC(=O)CC3=CSC=4SC(C)=CC3=4)=COC2=C1 C=C(C)C[C@@H1](NC(=O)C[C@H1]1C[C@H1]2C=C[C@H1]1C2)C(=O)NC3=CC=C(F)N=C3 C[C@H1](C1=CC=CS1)N(C)S(=O)(=O)C2=CN=C(N[C@@H1](C)CCC(C)(C)C)C(Cl)=C2 CCOCOC1=CC=C([C@@H1](NCCCOCC2CCCCC2)C(=O)OC)C=C1 C[C@H1](C(=O)N(C)CC[C@H1](NC(=O)CNC(=O)C1CCCCC1)C(C)C)C2CCC2 CC1=CC(C)=C(NC(=O)[C@@]2(CNC(=O)[C@@H1]3CC=CCO3)CCCO2)C=C1C CC[C@H1](C)C[C@H1](C)C(=O)N[C@@]1(C)CCN(C(=O)C2=C[NH1]C(Br)=C2)C1 C[C@H1]1[C@@H1]2C[C@H1]1CN2C(=O)[C@H1]3CCN3C(=O)C4=CC(Cl)=NO4 O=C(CN1C=NN=N1)NC[C@@H1]2CCN2CCC3=CC=C(OC(F)(F)F)C=C3 CP(C)(=O)[C@H1]1CCCC=C1C(=O)NC2(CNC(=O)C=3N=N[NH1]C=3Cl)CCCC2 CCOC(=O)C1(CC(=O)N(C)C[C@@H1]2CCCN2C(=O)COCC(F)F)CCC1 CC1=CC=C(O)C=C1NC(=O)[C@@H1](F)[C@@H1](C)CNC(=O)CCNC(N)=O C[C@H1](SC(F)(F)F)C(=O)NCCCCN(C)C(=O)CC1(O)CC1 O=C(COCC(F)F)N[C@H1]1CCN(C(=O)C2=CC(Cl)=NC=C2F)C[C@H1]1F CO[C@H1](CNC(=O)C1=CN=C(O)S1)CNC(=O)C=CC2=CN=C(O)N=C2O CCNC(=O)C1=CC=C(NC(=O)N[C@@H1](C)C2=CC=C([N+1](=O)[O-1])C=C2)C(C)=C1 CC1=CC(N2C=C([C@@H1]3CCCN3C(=O)[C@@H1](C)C4=CC=CC(F)=C4)N=N2)=CC=C1Br O=C([C@H1]1CC12CCOCC2)N3CC=4OC=C(C(=O)NC5C[C@@H1]6CCC[C@H1]6C5)C=4C3 CC1=CC=C2[NH1]N=C(C(=O)N[C@H1](C)C3=CC=C(C4=CC=CC=C4F)C=C3)C2=C1 CC1=CC(C)=C(C(=O)N[C@H1]2CCC[C@H1](C(=O)NCCOC3=NC=CC=N3)C2)S1 CC1=CC(C(=O)N2CC(CCNC(=O)C3=CC=C(C)C(F)=C3F)C2)=C(F)C=C1Cl CC[C@@](C)(O)C(=O)N[C@H1]1CN(C(=O)C2=COC(CO)=C2)CC[C@H1]1C O=C(C[C@]12CCC[C@H1]1C2)NC[C@H1]3C[C@@](F)(CNC(=O)[C@]45CC=CCN4CCC5)C3 CC1=NOC(C)=C1C[C@@H1](C)C(=O)N2CC(O)([C@@H1](C)NC(=O)CC3=CN=CC=N3)C2 COCC1=NC(C(=O)N[C@H1]2CCC[C@H1](NC(=O)COC(C)=O)CC2)=CO1 C[C@@H1](CC1=NC=CN1C)N=C2[NH1]C(=NCC3=NC(CO)=N[NH1]3)[NH1]C4=C2CCCC4 CC1=NC(C(=O)NC(C)(C)CCNC(=O)C23CC(CC(F)F)(C2)C3)=CO1 C=C(Cl)CCC(=O)NC/C=C/CNC(=O)C=1C=C(C2=CC=CC=C2OC)ON=1 CC=1[NH1]C(C(=O)NC2=CC=C(OCC#N)C=C2)=C(C)C=1C(=O)NC(C)(CO)CO CC1=CC=C(C(=O)N2C[C@@H1]3CN(C(=O)C4=CCCS4)CC[C@@H1]32)N=C1F CCOC(=O)NCCNC(=O)CCC1(NC(=O)C2=C[C@H1]3CC[C@@H1](C2)C3)CCCC1 CC1=CC=CC(OCCC(=O)NCC[C@H1]2CSCCN2C(=O)C3=CN=NN3C)=C1 CCOC(=O)C1(CC(=O)N2C[C@H1](NC(=O)[C@H1](O)C(C)(C)C)C3(CC3)C2)CCC1 CC=1C=C(CNC[C@@H1]2[C@H1](C(=O)NCC3=CC=CC=4[NH1]N=CC3=4)[C@@H1]2C)N(C)N=1 O=C(C=CCCC1=CC=CC=C1)N2CCN3C(=NN(CC(F)F)C3=O)C2 C[C@H1]1CC[C@@](C)(C(=O)N2CCC(F)(C(=O)N3CC[C@@H1]3C4=CC=CC=C4)CC2)C1 CC(Cl)(Cl)C(=O)N=C1C=C(C2=NC=CC=C2OC(F)F)[NH1][NH1]1 CNCCNC(=O)[C@]1(O)CCN(CC2=C[NH1]C3=CC=C(O)C=C23)C1 COC(=O)[C@@H1]1C[C@H1]1C(=O)N2CC[C@]3(CCCN3C(=O)C=4C=C(CO)[NH1]N=4)C2 CC1=COC2=CC=C(C(=O)N[C@@H1]3CCN(C(=O)CC=4C=NSC=4)[C@H1]3C5CC5)C=C12 O=C(COC(F)F)NC[C@@H1]1CCN(C(=O)CN2C=CC=N2)C13CCC3 C=C(C)CONC(=O)[C@@H1](CCSC)NC(=O)CCC1=CC=C[NH1]1 C[C@@H1](CNC(=O)[C@]1(C#N)C[C@H1]1C(F)(F)F)N(C)C(=O)C=CC2=CC=CC(F)=C2 CN1C=CC=C1CN2CCC[C@H1](C(=O)N[C@H1]3CC[C@H1](O)CC3)C2 C[C@@H1](NC(=O)C1=CC=CO1)C(=O)N[C@@H1]2C[C@@H1]2CNC(=O)C3CC4(CSC4)C3 C[C@H1]1CCCN(S(=O)(=O)C=2C=CC(=NC3CCC(C(C)(C)C)CC3)[NH1]C=2Cl)CC1 CN(CC1=CC=CC(F)=C1Cl)CC(=O)N2CC3(CCCCCC3)[C@H1]2CO COC1=CC=CC(C(=O)N[C@]2(CO)CCCN(C(=O)C[C@H1]3CC[C@H1](C)C3)C2)=N1 [N-1]=[N+1]=N[C@H1]1C[C@H1](C(=O)N2CC[C@@H1]3C[C@]32C(=O)N4CCC45CC(CO)C5)C1 COC1=C(Br)C=CC=C1C(=O)NCC2(CC=3N=N[NH1]N=3)CCC2 CC(C)S(=O)(=O)N1CCC[C@H1](C2CN(C(=O)[C@H1]3C[C@H1]3C4=CC=C(Cl)C=C4)C2)C1 C=C[C@H1](CC)CC(=O)NCC1(F)CC(NC(=O)C2=CN=CC=C2C(F)F)C1 C=C[C@@](C)(O)CC(=O)N1CC2(CCN(C(=O)CCC3=CN=N[NH1]3)CC2)C1 CN1C=CN=C1CNC(=O)C2(NC(=O)C3CCC(CO)CC3)CC(F)(F)C2 C1=CC=C([C@H1]2CCCCN2CCN(N3CCC[C@H1]3CCCCC4=CC=CC=C4)C)S1 CN1C=CC=C1C(=O)N2C[C@H1]3CC[C@]3(CCNC(=O)C4=NC=C(F)C=N4)C2 CCCC(CCC)CC(=O)NCCOCCNC(=O)[C@@](C)(COC)OC CCO[C@@H1]1C[C@@H1]1C(=O)NC2C[C@H1]3CN(C(=O)CC=4C(C)=NN(C)C=4C)C[C@@H1]3C2 O=C(N[C@@H1]1CC2(CN(C(=O)C=C(Cl)Cl)C2)N3C=CN=C31)C4=C[NH1]N=C4C(F)F CCN(C(=O)[C@H1]1CN2CCCN1CC2)C3CCN(C(=O)C[C@@H1]4CCCO4)CC3 C=CCOC1=CC=C(Cl)C(C(=O)N[C@H1](C)CNC(=O)[C@@H1]2CC[C@H1]3C[C@@H1]2C3(C)C)=N1 CC1=CSC(C(=O)NCC2=NO[C@H1]3CN(C(=O)C4=CC=C(C#N)C=C4)C[C@@H1]23)=C1C CN1N=NC(Br)=C1C(=O)N2CCC[C@@](O)(CNC(=O)C[C@H1]3CCCO3)C2 CC12CC(C(=O)N3CC[C@H1](C4CCN(C(=O)[C@H1]5OCCO[C@H1]5C)CC4)C3)(C1)C2 CC(C)CNC(=O)[C@]1(C)CCN1CC2=CC=CC3=C2CCCC3 CC1=NC=C(C(=O)N2CC3(CC[C@@H1]3NC(=O)C=C4CCCC4)C2)C(=N)[NH1]1 CC=1[NH1]N=C(C(=O)N2CCCC[C@H1]2[C@H1]3CCN(C(=O)[C@@H1]4CCC(=O)N4C)C3)C=1N CC12CC(C1)[C@@H1](C(=O)NCC3=CSC(C(C)(C)C)=C3)CO2 CC1=CN=C(CCC(=O)N2C[C@@H1](O)[C@H1](NC(=O)C(C)(C)CO)C2)[NH1]1 CCOC(=O)[C@@H1](C)CNC(=O)[C@@H1]1[C@H1](O)CCN1C(=O)CCSC CNC(=O)COCC(=O)NC(C)(C)CCNC(=O)C1=CSC2=NC=CN12 CCCCS[C@H1](C)C(=O)N1CCC(N(CCOC)C(=O)CC2CSC2)CC1 CC(C)(C)C(=O)NCCC(=O)N[C@H1]1CCCC[C@H1]1NC(=O)[C@@H1]2CC=CCC2 CC(C)C1=NN=C(CCNC(=O)NCCCCC2=CC=C(Cl)C=C2)S1 C=CC1=CC=CC=C1CN2CCC3=NC=C(NC(=O)C=4C=C[NH1]C=4)C=C3C2 CCC1=CN([C@H1](C)C(=O)N2CC3(C=C(C(=O)NCCC4=CCCCCC4)CO3)C2)N1 COC(OC)[C@H1](C)N(C)C(=O)CCC(=O)NC(C)C COC1=CC=C(C(=O)C2=CC=CC=C2C(=O)N(C)C3CC(CO)C3)C(Cl)=C1OC CCN(C(=O)CC1=CC=NN1C)[C@H1]2CCCN(C(=O)C[C@H1](C)OC)C2 CC1=NN=C(COCC(=O)NC[C@]2(NC(=O)CN3CCCCC3)CCOC2)S1 CCN(C)C[C@H1]1CC2N(C=CC(N3CCCC[C@H1](SC)C3)=NC(C(C)C)=N2)C1 CC(=O)C=1C=C(C(=O)N2C[C@@H1]3CCCN(C(=O)C=4C(C)=COC=4C)[C@@H1]3C2)OC=1C CC[C@H1]1CN(C(=O)[C@H1](C)C2CCCC2)C[C@@H1]1C(=O)N3CC(SC(F)F)C3 C=CC[C@@H1](NC(C)=O)C(=O)N[C@](C)(CNC(=O)C1=NC(OC)=CC=C1Cl)C(C)C C=C(C)COCC(=O)N1CC[C@H1]2CCC[C@]21C(=O)N3CC(SC(F)F)C3 COCC[C@H1]1C[C@@H1]1C(=O)NC[C@H1]2CC[C@H1](CNC(=O)C=3C=N[NH1]C=3)CC2 CC(=O)NC1CCC(C(=O)NC[C@@H1]2C[C@H1]3CC[C@H1]2N(C(=O)C=CC4CC4)C3)CC1 C[C@H1](NC(=O)C[C@@H1]1CCCN(C(=O)[C@@H1]2COC[C@H1]2C(N)=O)C1)C3CCOCC3 C[C@@H1](O)C1=CC=C(NC(=O)[C@]2(O)CCN(CC3=CC=CC(C(F)(F)F)=C3F)C2)C=C1 CC(=O)C(=O)N1CCC[C@@H1]1[C@@H1]2CCN(C(=O)[C@@]3(F)CCOC3)C2 NS(=O)(=O)C1=CC(C(=O)COC(=O)[C@H1]2CCCN2CC3=CC=CC=C3)=CC=C1Cl CC1=C(N)C=CC=C1C(=O)N2C[C@H1](F)[C@H1](N(C)C(=O)[C@H1]3CCCOC3)C2 C=C[C@@H1](O)C(=O)NC[C@H1]1CCN(C(=O)C2=NC=CC3=C2NCCC3)CC1(F)F CC1(C)COCC[C@H1]1C(=O)NC[C@@H1](CO)CNC(=O)C(=O)C2=CC=C(O)C=C2 COC(=O)C1=CC=NC=C1C(=O)N2C[C@H1](F)[C@H1](NC(=O)C34CC(CO3)C4)C2 CC[C@H1](C(=O)N[C@]1(CF)CCN(C(=O)C2=CN=CC(Br)=C2)C1)C3=CC=CN=C3 C=CC[C@@H1](CNC(=O)CC1=CSC(N2CCNC2=O)=N1)NC(=O)CCF CC1(C)C(CC(=O)NC[C@@](C)(CC(C)C)NC(=O)C2=CC=C(Cl)S2)C1(C)C CC[C@@](C)(OC)C(=O)N[C@H1]1C[C@@H1](OCC(=O)N(C)CC2=CN=CC=C2C)C1 COC[C@]1(CO)CCN(C2=NC(=NCC3=NC=CO3)[NH1]C4=C2CCC4)C1 CCCCC[C@@H1](O)C(=O)N1CCC[C@H1](C2CN(C(=O)COC3COC3)C2)C1 CC1=CC(C(=O)CCC(=O)N2CC(N3C=CC(O)=NC3)C2)=C(C)C(C)=C1C CCC(=O)N1C[C@H1](NC(=O)C[C@@H1](O)CN(C)C)C(C)(C)C1 COC(=O)[C@@]1(F)CCN(C(=O)[C@H1]2C[C@H1](NC(=O)C3=CN=C4[NH1]N=CC4=C3)C2)C1 CC1=CN=C(C(=O)N[C@H1]2C[C@@H1]3CN(C(=O)C4=CCOC4)C[C@@H1]3C2)C=N1 CO[C@@]1(CNC(=O)CCN2C=CC(C)=N2)CCN(C(=O)[C@H1](O)P(C)(C)=O)C1 COC(=O)[C@@H1]1C[C@H1](C)N1C(=O)[C@]2(C)CN(C(=O)[C@@H1]3CC34CCOCC4)C(C)(C)C2 NS(=O)(=O)NCC(=O)N[C@H1]1CCC[C@@H1](NC(=O)C=2C=C3N(N=2)CCNS3(=O)=O)C1 CN1C(=O)CC[C@@H1]1C(=O)N[C@@H1]2COC3(C2)CN(C[C@H1](O)CC(F)(F)F)C3 COC[C@]1(C)CCN(C2=NC=C(S(=O)(=O)NC34CC(F)(C3)C4)C=C2C#N)C1 C[C@H1]1CN(C(=O)C2=CN=C(O)N(C3CC3)C2=O)CCN1C(=O)[C@@H1]4C=CCCC4 CCCC1=NC=C(C(=O)N2CC3(CC3)C[C@@H1]2CNC(=O)[C@H1]4CN(C)CCO4)S1 CC(=O)C=CC(=O)N(C)C[C@@H1]1CCCN1C(=O)C2=N[NH1]C=C2Cl CC1=CC=C(C(=O)NC(C)(CO)CO)C(N2C=C([C@@]3(N(C)C)CCCC3)N=N2)=C1 CC(C)SCC(=O)N1C[C@H1](CNC(=O)CCC2=NC=NN2C)C[C@@H1](C)C1 C[C@@H1](C(=O)NCCC[C@@H1](C1(NC(=O)C=2C=CSN=2)CC1)C)C3=CCCC3 C=CC[C@@H1](CNC(=O)C1=CC=C(C#N)O1)C(=O)N(CC2=CC=CO2)C3CC3 COC1(C)CCC(NC(=O)[C@@H1](C)NC(=O)C2=CC=CC(=O)O2)CC1 C[C@](CO)(CNC(=O)CC=1C=CN(C(F)F)N=1)NC(=O)CCCC2=N[NH1]C(=N)S2 CC=1N=CSC=1CCC(=O)N2CCC([C@@H1]3C[C@H1]3NC(=O)C=4C=C(CF)ON=4)CC2 CC(C)CC1(NC(=O)CC[C@H1]2CC[C@@H1](NC(=O)[C@]3(C)CCN(C)C3)C2)CC1 CC=1[NH1]C(C(=O)N[C@@]2(CF)CCN(C(=O)CCC=3C=CN(C)N=3)C2)=C(C)C=1C CN(CC1(O)CN(C(=O)[C@H1]2C[C@@H1]2C=3C=NN(C)C=3)C1C)C=O C[C@]1(CNC(=O)CO)CCN(C(=O)CCN2C=CC=CC2=O)C1 CN(C(=O)COCCF)[C@@H1](C(=O)NCCOCC1CCC1)C2CC2 C#CC[C@]1(O)C[C@@H1](C(=O)N2CC(CN(C)C(=O)C3=CSC=C3C4CC4)C2)C1 CN1C=CC=C1C(=O)NC2CC(CNC(=O)C3=CC4=CC=C(Cl)C(F)=C4[NH1]3)C2 CC[C@@H1]1C[C@@H1](CC(=O)NC[C@H1]2CCN(C(=O)C3=CC=C(F)C(O)=C3F)C2)CCO1 CC(C)OC1=CC=CC(C2=CC=C3SC(C(=O)NC=4C=NN(C5CC5)C=4)=CC3=C2)=N1 C#CCN1C=CC=C1C(=O)NC[C@@H1](C)CNC(=O)C2=CC=CS2 CN(C(=O)C(C)(C)CNC(=O)CC1=CN=NS1)C2CC(CO)C2 C#CC[C@@]1(C(=O)N2CC3(CCOCC3)C[C@H1]2CNC(=O)C4(O)CCC4)CCCO1 CC1=CC=C(NC(=O)C2=N[NH1]C3=C2CN(CC4=CC=CC(F)=C4O)C3)C(C)=C1C C=CC=CCC(=O)NC[C@@H1](CC)NC(=O)CN1N=CC2=CC=CC=C21 CN(C)C/C=C/C(=O)N1CCCO[C@@H1](CNC(=O)C2=CC3=CC=C(Cl)N=C3S2)C1 O=C(C#CC12CC3CC(CC(C3)C1)C2)NCC4(O)CN(C(=O)CCC(F)F)C4 C#CC1=CC(N[C@@H1](C2=NC(Br)=CS2)C3=NN=NN3C[C@@H1]4CCCO4)=CC=C1Cl CCC1(C(=O)NC2=CC=C(NC(=O)CCN3C=C(Br)C=N3)C=C2C)CC1 CC[C@@H1](C(=O)N1CC[C@@H1](NC2=NC(C(F)F)=NC(=N)[NH1]2)C3(CCC3)C1)N(C)C C#CCCCC(=O)N1CC([C@@H1](O)C(=O)N(C)[C@@H1]2COC[C@@H1]2OC)C1 CCCCCC[C@H1](CC)NC(=O)[C@H1]1CCCC[C@H1]1NC(=O)[C@H1](C)CO CN(CCN(C)C(=O)[C@H1]1CN2CC[C@H1]1C2)C(=O)CC=3C=CC4=NSN=C4C=3 CC(C)[C@@H1](CCNC(=O)C[C@H1](O)CNC(=O)[C@]1(C)COCCO1)N(C)C COC1(CNC(=O)CC2=C(Cl)C=NN2C)CN(C(=O)[C@H1]3CC(=O)C3(C)C)C1 CC[C@@H1]1CN(C(=O)[C@@H1](C)CS(C)(=O)=O)CC[C@H1]1NC(=O)C23CC(C)(C2)OC3(C)C COC(=O)[C@@H1]1C[C@@H1](S(C)(=O)=O)CN1C(=O)NCCNC(=O)C2=CN=C(Cl)S2 CC=1[NH1]N=C(C(=O)N2C[C@@H1](NC(=O)[C@@H1]3CC[C@H1]4C[C@H1]4CC3)CC25CCCC5)C=1O CC1=C(NCCC2=C[NH1]C3=CC=C(Br)C=C23)C=CN=C1F CC1=NC(CC(=O)N2CCN(C(=O)[C@@H1]3CC(=O)[C@H1]3C)C[C@H1]2CC(F)F)=CO1 CC1=CN(C)C=C1C(=O)N[C@@H1]2CCCN(C(=O)C3=COC4=C3C(=O)CCC4)CC2 O=C(CCSC1=CC=C(Cl)C=C1)NC[C@@H1]2C[C@H1]2NC(=O)C[C@@H1]3CC4(CCC4)CO3 CC=CCC(=O)N1C[C@@H1](F)C[C@H1](NC(=O)CC2=CC=CC=C2SC)C1 CCCCC[C@@H1](C)CC(=O)N1CCC(OCCCNC(=O)[C@@H1](O)CCSC)CC1 CCCC=CC(=O)N(C)[C@@H1]1CCC[C@H1](N(C)C(=O)C=2C=C(O)N(C)N=2)C1 O=C(N[C@@H1]1CCN(C(=O)COCC(F)(F)F)C[C@H1]1O)[C@H1]2CCS2(=O)=O CC1=CC(F)=CC=C1C=2C=NN3C=2CN(CC4=CC=NC=C4C(F)(F)F)CC3 C[C@@H1]1CN(C(=O)C2(N3C=C(Cl)C=N3)CC2)C[C@H1]1NC(=O)[C@]4(F)CC=CCC4 CCN1N=NN=C1[C@H1](NCC=2C=CN(C(C)C)N=2)C3=CC=C4C(=C3)[C@@H1](C)[C@H1](C)O4 O=C(NC[C@]1(CO)CC12CCNCC2)C3=CN=C(COC4=CC=CC=C4)S3 COC1=CC=C(C(=O)N[C@@H1]2C[C@H1]3CC[C@@H1]([C@@H1]2C)N3C(=O)OC(C)(C)C)C(C)=N1 CCC1=CC(C(=O)NCCC2(CNC(=O)C3=CC=NC=C3O)CC2)=CC(O)=N1 CC(C)NC1=NC(C(=O)N2CCN(C(=O)[C@@H1](C)CC3=CC=NN3C)C[C@@H1](CO)C2)=N1 N=C1N=C(C2CCCC2)N=C(N3CC[C@H1](CCNC(=O)CN=S(C)(C)=O)C3)[NH1]1 CCO[C@H1](C(=O)NC1C[C@@H1](C2=N[NH1]C=C2CNC(=O)C=CCO)C1)C(C)C CCCC[C@H1](CC)CC(=O)N1CC[C@@H1](F)[C@H1](NC(=O)C2=CC=CN2C3CC3)C1 CC[C@H1](CC(C)C)C(=O)N1CCC[C@@]12CCN(C(=O)[C@H1](O)CC(F)(F)F)C2 C[C@]1(C(=O)N2C3[C@H1]C(CNC(=O)CCN4CCOCC4)=NO[C@H1]3CC2)C=CCC1 CCCC(=O)NCC(=O)NC[C@H1]1C[C@H1](C)N(C(=O)C2=CC=C(C(C)(C)C)O2)C1 CN1C(=O)CC[C@@H1]1CC(=O)NC[C@H1]2C[C@H1](NC(=O)CN3C=NN=C3O)C2 CCNC(=O)C(=O)N1CC[C@](O)(CNC(=O)C=2C=NN3C=2OC[C@H1](C)C3)C1 CN(CC1(O)CCN(C(=O)C=2[NH1]N=C([N+1](=O)[O-1])C=2Cl)CC1)C(=O)CC(F)(F)F CO[C@H1](C)C(=O)N[C@@H1]1CN(C(=O)[C@H1]2C[C@H1]3[C@@H1](C2)C3(F)F)C4(CCOCC4)C1 C[C@H1]1OCCN([C@@H1](C(=O)NC[C@H1]2CCCO2)C=3C=CSC=3)[C@@H1]1CCO CC1=CC=C(CCC(=O)N[C@]23CCC[C@H1]2N(CCC[C@@H1]4CCOC4)CC3)S1 CCC[C@H1](C)CC(=O)N[C@@H1]1CN(C(=O)C=2[NH1]C(C)=CC=2C)CC[C@H1]1C C=CCOC(C)C(=O)NCCCCN(C)C(=O)COCC COC1=NC=C(C(=O)N2C[C@H1](NC(=O)C=3ON=CC=3C)CC(F)(F)C2)C=N1 CCC(CC)(CO)CNC(=O)NC1=CC(F)=C(F)C(Br)=C1 CC(C)(C)OC(=O)CCCC(=O)N1CCC[C@@H1]1[C@@H1]2CCCN(C(=O)C=CBr)C2 CSC1=NC=C(C(=O)NCC2[C@@H1]3CN(C(=O)[C@@H1]4CCOC4=O)C[C@@H1]23)C(Cl)=N1 CC=1SC(O)=NC=1C(=O)N2CC[C@H1]3CCN(C(=O)CC[C@H1]4CCCOC4)[C@@H1]3C2 CC(C)C1=CC(C(=O)N2[C@H1]3CC[C@@H1]2C[C@H1]3NC(=O)C4=CC=5C=CSC=5S4)=NO1 CC(=O)N(C)[C@H1](C)C(=O)NC1(CNC(=O)[C@@H1]2CCCCS2)CCC1 CN(C)CCCC(=O)N1CCN(C(=O)CC(=O)NC2=CC=CC=C2O)[C@H1](CF)C1 CCCCNC(=O)[C@H1]([C@H1]1CCO[C@@H1](C(C)(C)C)C1)N(CC)C23CC(C2)C3 CC1=CC=CC(O[C@H1](C)C(=O)NCCOCCNC(=O)[C@]2(C#N)CC2(C)C)=C1 CC=1N=CN(O)C=1C(=O)N[C@@H1](C)CCCNC(=O)[C@@H1]2CC3(CCCC3)CO2 CSC1=CC(Br)=CC=C1C(=O)N[C@H1](C)CCN(C)C(=O)[C@@H1](F)OC C=CCCO[C@@H1](C)C(=O)N1CCCN(CCNC(=O)C2=CN=CC(F)=N2)CC1 CC=1OC(Br)=CC=1C(=O)NCCN(C)C(=O)[C@H1](O)C2=CC=C(F)C=C2 O=C(NC[C@]12CCCN[C@@H1]1CCC2)C=3C=CN([C@H1]4CC4(F)F)N=3 C[C@@H1]1OCC[C@@H1]1C(=O)NC[C@H1]2CCCN(C(=O)C3=CC(C(F)(F)F)=NN3C)CC2 O=C(C=1OC=C2C=1CCC2)N3C[C@@H1]4C[C@H1]3CN4C(=O)[C@@H1]5CS(=O)(=O)CC56CCC6 CC1=CC=CC=C1C(=O)N2C[C@H1](CNC(=O)C=3C=C[NH1]C=3C4CCC4)C[C@H1]2C COC(=O)[C@@H1](O)CNC(=O)C[C@]1(C)CCN1C(=O)CC2CC(F)(F)C2 CC=1C=CN2N=CC(C(=O)NC[C@@H1](CO)CNC(=O)CC=3C=CN(C)N=3)=C2N=1 CC1(NC(=O)C2CCC(OCCC3CC3)CC2)CN(C(=O)CCCNC(N)=O)C1 COC(=O)C1=CC(C(=O)N2[C@H1]3CC[C@H1]2CN(C(=O)[C@]4(C)C[C@@H1]4Br)C3)=CN1C CN(CCCNC(=O)[C@H1]1CCCC[C@H1]1C(C)(C)C)C(=O)C2=C(F)C=CC(F)=C2F CC(C)=C(C)CC(=O)N1C[C@@H1](CC(=O)NC[C@@H1]2CC(C3CC3)=NO2)CC1(C)C CC(C)CC1(C(=O)NCC2(CNC(=O)[C@@H1]3CCCS3(=O)=O)CCCC2)CCC1 CC1=CC(C=2C=COC=2)=CC=C1C3=NC=CN3CCC4(C)CC4 CCCN(C)[C@H1](C)CCNC(=O)C1=CC([N+1](=O)[O-1])=CC=C1N2CCOCC2 CN1CCCN(C(=O)C2=CSC(NC3=CC=CC=N3)=N2)C1=O CCCCCCC=1N=C(C2=NC=CC=3C=CN(C)C2=3)N(C4=CC=CC=C4)N=1 CCS[C@H1](C)C(=O)NCCOC1CCN(C(=O)[C@@H1](C)CC(F)F)CC1 C#CC[C@H1](C(=O)NC(CC)(CC)CNC(=O)C(C)(C)N1CCOCC1)C2CC2 COC1=CC(O)=C(CNC[C@@H1]2CCCC[C@@H1]2C(=O)N(C)C)C=C1OC CC(=CC(=O)N[C@@H1](CC(C)C)CN1C=C([C@H1]2CCN(C)C2)N=N1)C3=CC=CC=C3 O=C1C[C@@H1](C(=O)N[C@@]23CC[C@@H1](C2)N(C(=O)C4=CC(Cl)=C(Cl)[NH1]4)C3)NC(=O)N1 CC=CC(=O)N[C@H1]1CCC[C@H1](N(C)C(=O)C2=CC3=CC=CC(Cl)=C3S2)C1 CC(C)[C@@H1](O)CNC(=O)C1(N(C)C(=O)C2=C[NH1]C(=N)O2)CC1 CCO[C@H1](C(=O)N1CCC[C@@]2(CCCN2C(=O)C3=CN=CO3)C1)[C@H1]4CCOC4 COC1=N[NH1]C=C1C(=O)N2CC=C[C@@H1](C(=O)NC[C@](C)(O)C(F)F)C2 CC=1C=CSC=1C(=O)N2CC[C@@H1](O)[C@H1](NC(=O)C=CC3CCOCC3)C2 CCN(C(=O)C1=CSN=C1C)[C@H1](C)CNC(=O)[C@@H1]2NC(=O)[C@H1]3CC[C@H1]32 CCC(C)(C)N[C@@H1](C)C(=O)N(C)C[C@@H1](O)CN(C)C(=O)COC=1C=C(C)ON=1 CCN(CC)C[C@H1](F)C(=O)NC[C@H1]1CC(F)(F)CN1C2=NC3=CC=CC=C3O2 O=C(C1=CN2C(C3=CC=CN=C3)=CC=CC2=N1)N4CCOC[C@H1]4CO CC1(C)CCN(C(=O)[C@@H1]2CCCCC2(F)F)C[C@@H1]1NC(=O)CCN3C=NC=N3 CO[C@@H1](C(=O)N[C@@H1](C)CC1CCN(C2=NC=NC(C)=C2F)CC1)C3CCC3 CC1=NOC(C)=C1SCCN=C2[NH1]C(=NCC3(C4CC4)CC3)C=5[NH1]C=CC=5[NH1]2 COC1=C[NH1]C([C@@H1](NCC(=O)N(C)C)C2=NN=NN2[C@H1]3CCOC3)=CC1=O CCC1=CN=C(O)C(C(=O)N2CC(O)(CCNC(=O)C3C4CCC4C(C)(C)C3)C2)=C1 CN(C[C@@](C)(O)C1CC1)C(=O)[C@@H1]2CC(C)(C)CCN2C(=O)CC3=CCOCC3 CC[C@@H1](C)CC(=O)N(C)CCCCN(C)C(=O)C1=CC=C(C2CCC2)N=C1 CC[C@@H1](C(=O)N1C[C@H1](C)[C@H1](NC(=O)[C@@H1]2CC[C@@H1](C)C2)C1)CC3=CC=CC=C3 O=C(N[C@H1]1C[C@H1](O)C[C@@H1]1O)[C@H1]2CCCN2C(=O)C=3C=NN(CCO)C=3 CN1CC(C)(C)C[C@@H1]1C(=O)N2CCC3(CC(NC(=O)CSS(C)(=O)=O)C3)C2 CC[C@H1](C)CC(=O)C(=O)N1C[C@H1]2[C@@H1](C1)[C@@H1]2C(=O)N(C)CC(N)=O CCOC(=O)C1=CC(C(=O)N[C@]2(C3=CN(CCOC)N=N3)CCCOC2)=CC=N1 C=C(C)C[C@H1](NC(=O)C1=CN=NC(C)=C1)C(=O)NCCCC(F)F CC(C)(C(=O)N1CCCC[C@@H1](CNC(=O)/C=C/C=2C=COC=2)C1)N3C=C(Cl)C=N3 CN1CCC[C@@H1](CC(=O)NC2C[C@H1]3C(NC(=O)C4=C[NH1]C=CC4=O)[C@@H1]3C2)C1 COC[C@@]1(NC(=O)C2=CSC(Cl)=N2)CCN(C(=O)C3=CC=C(OC)N=C3Cl)C1 C[C@@H1]1[C@H1](NC(=O)[C@H1]2CCC=CCCC2)CCCN1C(=O)[C@H1]3CC34CC4 C[C@H1]1CN(C(=O)[C@@H1]2[C@H1]3CC[C@@H1](C3)N2C(=O)C4=CC(Br)=CC=C4Cl)CC[C@@H1]1O CCCC=CC(=O)NC[C@H1]1C[C@@H1](NC(=O)C2=NC=C(Cl)N=C2Cl)C1 CCCN(C(=O)[C@H1]1C[C@H1]1C)C2CCN(C(=O)[C@@H1]3CCC4=NN=CN4C3)CC2 O=C([C@@H1]1C[C@]1(F)Cl)N2CC[C@H1]3CC[C@@H1](C2)N3C(=O)C4=CC=C5N=CC=NC5=C4 O=C(NC[C@H1]1CCCN1C(=O)C2=C(O)C=C(O)C=C2O)C3=CN=CN=C3 C=C(Cl)C(C)(C)C(=O)NC[C@@H1]1C[C@H1](COC)CN1C(=O)[C@H1]2CC2(Cl)Cl CCCCOCC(=O)N1C[C@@H1](CCNC(=O)C=CC2=CSC(C)=N2)O[C@H1](C)C1 CC[C@H1](C)[C@H1](C(=O)N1CCC(C(C)(C)CNC(=O)C#CC2(C)CC2)CC1)N(C)C C=C[C@@H1](O)C(=O)N1CC[C@@H1](CN(C)C(=O)C2=CC(C)=NC=3[NH1]N=C(O)C2=3)C1 CC1=CC=C(C(=O)N2CC[C@](O)(CN(C)C(=O)C3=CSC(F)=C3)C2)C(C4CC4)=N1 C[C@]1(Br)C[C@@H1]1C(=O)N2CCC(CCCNC(=O)C3CC3)CC2 CC[C@@H1](CNC(=O)CC[C@H1]1CC1(F)F)NC(=O)C2=CC=C(N)C(Cl)=C2 COC(=O)COCC(=O)NC1CCC(NC(=O)[C@@H1]2CCOC3(CCCC3)C2)CC1 COCC1(C(=O)N2C[C@H1](C)[C@@H1](NC(=O)CCC3=NC=CS3)C2)CC1 CC[C@@H1](CSC1=CC=CC=C1)NC(=O)C=CC=C([N+1](=O)[O-1])CCC C=COCCCNC(=O)C1=CC=C(CNC(=O)C2=COCCC2)C=N1 CCCCCCCC(=O)NC(=O)COC(=O)C1=CC=C(N=[N+1]=[N-1])C(F)=C1 C[C@H1](NC(=O)C1=CC=C(Cl)S1)[C@@H1]2CCN(C(=O)CCSC3=CC=CC=N3)C2 CN1CC[C@@](NC(=O)C=CC2=CN=CC=N2)(C(=O)NCC=3SC(C)=NC=3C)C1 C=CCOCCCC(=O)N[C@H1](C)[C@@H1]1CCN(C(=O)[C@@H1]2CCC[C@H1](F)C2)C1 O=C(CC1=CC=CC(F)=C1)NC[C@H1]2CC(C(=O)N3C[C@H1]4C[C@@]4(CO)C3)=NO2 CC1=CC=C(C(=O)N2C[C@H1](C)[C@H1](CNC(=O)C3=COC(C4CC4)=N3)C2)C(N)=C1C CSC1=NC(C2CC2)=CC(C(=O)NC[C@@H1]3CCN(CC4CCOCC4)C3)=C1C#N CCOCCOCC(=O)N1C[C@H1](CC)[C@@H1](C(=O)N(CCO)C[C@@H1](O)CO)C1 COC1=CC=C(Cl)C(S(=O)(=O)N[C@H1]2CN(CC3=CC=C(Cl)C(I)=C3)CC2(F)F)=C1 CCONC(=O)CNC(=O)CC[C@@H1]1CCCN(C(=O)C(C)(C)C(=O)NC)C1 CCN(C[C@H1](C)C#N)C(=O)CCOCCCNC(=O)[C@@H1](C)C#N C=C(Cl)CCC(=O)N[C@@H1](COC)CC(=O)N(C)C1(C=2C=C[NH1]N=2)CC1 CC1=CC(F)=CC(C(=O)NCCOCCNC(=O)C2=NC(C)=CC=C2Br)=C1 CCC1=CC(C(=O)N[C@H1]2CCN(C(=O)C3CC4(CC(F)C4)C3)C2)=NC=N1 C[C@@H1](NC(=O)CC1=CC=C(F)C=N1)C2(O)CCN(C(=O)[C@H1](F)OC(F)(F)F)CC2 CCOC1=NC=CC=C1NC(=O)[C@]2(C)CCN2C(=O)C3=CC(O)=C(O)C(OC)=C3 O=C(N[C@H1]1CCCCC[C@@H1]1CO)[C@@H1]2[C@H1]3C[C@H1]3CN2C(=O)C4=CC(O)=CS4 C[C@@H1]1CC[C@@]2(CCN(C3=NC=NC(NCCC4=CC=C(F)C=C4F)=C3C)C2)C1 COC(=O)[C@@H1]1[C@H1]2CN(C(=O)[C@]3(C(C)C)CCN(C(=O)[C@@H1]4[C@H1](C#N)C4(C)C)C3)C[C@H1]21 CC[C@H1](O)C(=O)N1C[C@H1](CNC(=O)C2=CC(O)=NC(C)=N2)CC13CCC3 CC[C@H1](C)NC(=O)[C@H1](C1=NC(Br)=CC=C1F)N2C[C@H1](C)O[C@@H1]3CCCC[C@@H1]32 C[C@](O)(C(=O)NC1[C@H1]2C[C@H1]1CN(C(=O)CCN3CCCS3(=O)=O)C2)[C@@H1]4CCOC4 C[C@@H1]1CCN(C(=O)C2=CSC(=N)[NH1]2)[C@@H1]1CNC(=O)CNC(=O)C(F)(F)F CCN(CC)S(=O)(=O)CC(=O)NC1CC(CCNC(=O)C2=NC=C(F)C=C2F)C1 CC=1C=C(C(=O)N[C@@H1](C)[C@@H1](C)NC(=O)C2=NC(=N)[NH1]C3=CC=CC=C23)SN=1 CC1=CC(OCC(=O)O)=CC=C1NC(=O)[C@@H1](O)C(C)(C)C CCC(CC)C(=O)N[C@H1]1CC[C@@H1](NC(=O)[C@@H1](CC2=CC=CC=C2F)N(C)C)C1 C=CC1(C2=NC(C3CCCC3)=NN2CCOCC4=CC=CC=C4)CC1 CCO[C@@H1]1C[C@H1]1C(=O)N2C[C@@H1](C(F)(F)F)C[C@H1]2CNC(=O)C(C)(C)COC CCC[C@H1]1CN(C(=O)C2(O)CC2)C[C@@H1]1C(=O)N[C@@H1]3[C@H1]4CC[C@H1](C4)[C@@H1]3CO O=C(NC[C@@H1]1CCCC[C@@H1]1NC(=O)C2=CN=C3N2CCS3)C4=CSN=N4 CCC(=O)N[C@H1](C)C(=O)N1CC=C(CNC(=O)CS(=O)(=O)CCO)CC1 CO[C@H1]1C[C@@H1](C(=O)NC[C@@H1](C)NC(=O)[C@@H1]2CCS2(=O)=O)C1 C=C[C@@](C)(CC)C(=O)N1C[C@H1]2CC[C@@H1](C1)C2CNC(=O)C3=NC(C)=CC=C3F CCCC1=CC(C(=O)N2CC3(CNC(=O)C[C@@](C)(O)CCC)CCC2CC3)=N[NH1]1 C#CCOCCC(=O)N1CC[C@H1]2CC[C@@H1](C1)N2C(=O)C3=CCCC[C@H1]3C COC(=O)[C@@H1]1CCC[C@@H1]1C(=O)NC2(C)CN(C(=O)CCN3CCCCC3)C2 C=CC(C)(C)NC(=O)[C@H1](CC1=CC=CO1)NC(=O)C=NOC CC[C@@H1](CC(=O)N[C@@](C)(CC)CNC(=O)C1=CC(OC)=C(Br)S1)OC CCCSCC(=O)N[C@@H1]1CN(C(=O)C2=CC3=C(O)C=CC=C3[NH1]2)C[C@@H1]1C CNC(=O)NCCC(=O)N1CCC[C@@H1](N(CCF)C(=O)C2=CC=C(Br)C=N2)C1 C#CC[C@](C)(CC)C(=O)N[C@@H1](C)CN(C)C(=O)CSC1=CC(C(C)C)=CC=C1C C=CCN1C=C(C(=O)N2CCC[C@@H1](CC(=O)N3C[C@@H1](CC)O[C@H1](C)C3)C2)N=N1 C[C@H1](OC1=CC=CC=C1)C(=O)NC2(CCNC(=O)C[C@H1]3CC(=O)NC3=O)CC2 COC1=CC(C(=O)NC2=CC=CC(CC(F)(F)F)=C2)=CC3=C1OCCO3 O=C(C1=NC=C(F)C=C1F)N2CCC[C@H1](C3=NC(=O)O[NH1]3)C2 CCC[C@@H1](CC)CC(=O)N(C)[C@H1](C)CNC(=O)C1=CN(CC)N=N1 CCCC1=NC(C(=O)N[C@@H1]2CN(C(=O)/C(C)=C/C3=CC=C(C)C=C3)C[C@@H1]2C)=CS1 CC[C@H1](CN(C)C(=O)C=1N=CN(C)N=1)NC(=O)C2=CSC(CC3=CC=CC=C3)=C2 CC1=CC(F)=CC(C2(NC(=O)NCCCF)CC2)=C1 O=C(N[C@@H1]1CN(C(=O)C2=CC=CC=C2F)C[C@@H1]1F)C3CCC4(CC3)OCCO4 COC1=CC(C)=CC(CN2C[C@@H1]3C[C@]3(C(=O)NCC4=CC=NC5=CC=CC=C45)C2)=C1 CCN1N=C(C)C(C(=O)N2CC[C@H1]3C[C@H1]2CN3C(=O)C4=NN(C)C(C)=C4Cl)=N1 O=C(N[C@@H1]1[C@@H1]2CN(C(=O)C3=CC=C(F)C(I)=C3)C[C@@H1]21)C4=CC=NC(F)=C4Cl O=C1CC[C@@H1](C(=O)N2C[C@@H1](CNC(=O)C3=CC=C([N+1](=O)[O-1])O3)[C@H1]4CCCC[C@H1]42)N1 CCC[C@H1](CCCNC(=O)CC1=CC=CC=C1C(C)C)NC(=O)[C@H1]2CNC(=O)C2 CCOC1=CC=CC=C1[C@@H1](C)N[C@@H1](C=2C(Br)=N[NH1]C=2C)C3=NN=NN3CC4CC4 C[C@H1](NC(=O)OC(C)(C)C)[C@H1](C(=O)NC1CCC1)N2CC[C@@H1](O)[C@@H1](C)C2 C#C[C@H1]1CN(C(=O)[C@@H1](CC(=C)Cl)NC(=O)C2=CC(O)=NC(C)=N2)CCO1 C=CCCC1(C(=O)N2CCC=C[C@H1]2COC)CN(C(=O)CC3CCSCC3)C1 CCC1=CC=CC(C(=O)N2CC(NC(=O)C(=O)C3=CC=C(O)C=C3)C2)=C1 CCN(CC(C)(C)CNC(=O)C1=CC=C(N)C(F)=N1)C(=O)CCC=2C=C(C)ON=2 CN(CC1CCN(C(=O)C2=CC=C(C(F)(F)F)N=C2)CC1)C(=O)CSS(C)(=O)=O CNS(=O)(=O)CC(=O)N1C[C@H1]2CCC[C@@]2(CNC(=O)CS(=O)(=O)C(C)C)C1 CC1=CC=CC=C1C=CC(=O)N[C@H1]2C[C@@H1](O)CN(C(=O)C3=CC=CN=C3C)C2 CCCC1=CC=C(CC(=O)NC[C@@H1](C)CN(C)C2=NC=C(C#N)C=C2Br)C=C1 CC1=CC(O)=NC=C1C(=O)N[C@H1]2CN(C(=O)CCSC3=CC=CC=N3)CC[C@H1]2C O=C(NC[C@@H1]1CC(F)(F)CN1C(=O)C[C@H1]2CN3CCC2CC3)[C@H1]4CC45CCCC5 CCC1=C[NH1]N=C1C(=O)N(C)[C@@H1]2CC[C@H1](NC(=O)COC3=CC=C(F)C=N3)C2 O=C(C#CC1CC1)NC2(CC(=O)NC3=CSC4=NC=CN=C34)CC2 COCCO[C@H1](C)C(=O)N[C@H1](C)CCNC(=O)C12[C@H1]3CC(C[C@H1]31)C2(F)F C[C@H1](CO)N(C(=O)CN1CCN(C(=O)CN(C)C2CC2)CC1)C3CC3 CCN(CCCNC(=O)CC1(C)CC1)CC(=O)NC2=CC=CC=C2C CC(C)[C@@H1](O)[C@@H1](C)C(=O)N[C@H1]1CC=C(C(=O)NC2CC3(C2)CC4(CCC4)C3)C1 CCC1=NOC=C1[C@@H1](N[C@]2(C)CC2(C)C)C3=NN=NN3C4CCOCC4 C=CCOCCN=C(NCC1=CN(CC)N=N1)N[C@H1]2C[C@]2(C)C(C)C CCCC1=NC(C(=O)N(C)[C@@H1]2CN(C(=O)C3CC(C(C)C)C3)CC2(C)C)=CO1 CC=C[C@@H1](O)C(=O)NC1CC(C)(C(=O)NC[C@@H1]2CC(=O)N(C)C2=O)C1 C[C@@H1]1CC[C@@](C)(C(=O)N[C@@H1]2CN(C(=O)C=CC3=CC=C(C(N)=O)O3)CC[C@H1]2)C1 CO[C@H1]1C[C@@H1](CC(=O)N[C@@]23CC[C@@H1](CN(C(=O)C=4[NH1]C=CC=4C)C2)C3)C1(C)C COCCO[C@H1](C)C(=O)N(C)C[C@H1]1CCN(C(=O)CCN(C)S(C)(=O)=O)C1 [N-1]=[N+1]=NC1=CC=C(C(=O)N2CC[C@@H1](OCCNC(=O)[C@@H1](F)C3CCCC3)C2)C=C1 CC=1C=C(C(=O)N2C[C@@H1]3CC[C@]3(C(=O)NCCC(C)(C)C)C2)ON=1 CN(C)CCCC(=O)N1CCC2(CCCN2C(=O)CC3=CC=C(O)C(Cl)=C3)CC1 COC(=O)C1=CN(CC(=O)N2CCN(C(=O)C3=NO[C@H1](C)C3)[C@@H1](CF)C2)N=N1 CCC[C@@H1](C)C(=O)N[C@@](C)(CNC1=NC=C2C(=N1)COC2)CC(C)C CCO[C@@H1](C)C(=O)N1CC(C2CN(C(=O)C3=CC=C(C)N=C3C(C)C)C2)C1 CN(C(=O)C1CCSCC1)[C@H1]2CCCCN(C(=O)[C@@H1]3CCOCC34CCC4)C2 CC[C@@H1](C(=O)NC[C@H1](C)N1CCCCC1)N(C)C(=O)CCC=2C=NN(C)C=2 CC1(C(=O)N[C@@H1]2C[C@H1]3C[C@H1]2[C@@H1](O)[C@@H1]3O)CC(NC(=O)CC4CC4)C1 NC1=CC=NC(C(=O)NCCCC[C@@H1](CO)NC(=O)CN2C=NN=C2O)=C1 CSC(C)(C)/C=C/C(=O)NCC1=CSC(CNC(=O)[C@H1]2C[C@H1](C#N)C2)=N1 CCC1=CC(C(=O)N(C)CCCNC(=O)C[C@@H1]2CCC[C@@H1](C#N)C2)=C(C)O1 O=C(NCCOC(F)F)[C@@H1]1CSCCN1C(=O)[C@@H1]2CCS2(=O)=O C[C@@H1]1CC[C@H1](O)[C@H1](NC(=O)CC2(NC(=O)[C@H1](C#N)C(C)(C)C)CC2)C1 O=C(CC1=NC(Cl)=CS1)N[C@@H1]2CC23CCN(CC=4C=CC5=NON=C5C=4)CC3 O=C(C1CCC(C2=CC=CC=C2)CC1)NCCCC3=CC=CC=C3F CC1=CC=C(C(=O)N[C@@](C)(CO)CNC(=O)[C@@H1]2S[C@H1]3C=C[C@H1]2CC3)C=N1 O=C(NC1CC1)[C@@H1]2CN(CC3=C(Br)C=CC(Cl)=C3Cl)CC[C@@H1]2O CN1C=NC=C1[C@@H1]2CN(C(=O)C=CC=3C=C[NH1]N=3)C[C@H1]2NC(=O)C4=CN=C(S)[NH1]4 C[C@H1]1C[C@H1]1CCCCOC(=O)[C@@]2(O)CCCC(C)(C)C2 CCCCC1(C(=O)N(CC)C[C@H1](C)NC(=O)C[C@H1]2CC3(CCC3)CO2)CC1 O=C(NCCC1CN(C(=O)C2CC(=C(F)F)C2)C1)C3=CC=CC(F)=C3 CO[C@@H1]1C[C@@]2(C(=O)NC(C)(C)CNC(=O)[C@@H1]3CC(C4CC4)=NO3)C[C@@H1]12 CC1=CC(C)=C(C(=O)N2CC[C@@H1]2CNC(=O)C3=CC(Cl)=CC=C3O)S1 CO[C@H1](C)CC(=O)NCC1=CC=CC(NC(=O)C2=CC=C(Cl)C=C2C)=C1 C[C@H1]1CC[C@@H1](NC(=O)C=2C=CN(C)N=2)CN1C(=O)C3=N[NH1]C(C4CC4)=N3 CC[C@H1](CC(=O)N[C@@H1]1CN(C(=O)C2=CN=C3C(=C2)NC(=O)CO3)C[C@@H1]1O)C4CC4 CC(C)=C(C)C(=O)N(C)[C@@H1]1CC[C@H1]2CN(C(=O)CC3=CC=C(C4CC4)C=C3)C[C@@H1]21 CC(C)(C)C1=CC=C(C(=O)NCC2(O)CN(C(=O)CC3(O)CCC3)C2)[NH1]1 CC1=CC=C(C(=O)N2CCC[C@H1](C(=O)NCC3CC(I)C3)C2)C=C1 CCC[C@@H1](O)CC1=NC(C2=CC=C(Cl)N=C2)=NN1C3=CC=NC(Cl)=C3 C[C@@H1](C(=O)NC[C@@H1](CO)CNC(=O)C1=CC=C(C2=CC=CN=C2)C=N1)C3CCC3 O=C(OCC[C@H1]1CC=CCC1)[C@@H1]2C[C@H1]2C3=CC=NC=C3Cl CN(C)CCCN(CCNC(=O)OC(C)(C)C)C(=O)[C@H1](O)C1=CC=C(Cl)C(Br)=C1 CCC[C@H1]1CC[C@H1](C(=O)N2CC[C@@H1]2C(=O)NCC3(N(C)C)CCOCC3)CC1 O=C(N[C@]1(C(=O)O)CCCC12CC2)[C@@H1]3CCNC4=CC=CC=C43 C=C1CC(C(=O)N2CCC[C@](F)(CNC(=O)C3CCC(=C(F)F)CC3)C2)C1 C[C@H1]1C[C@]1(F)C(=O)N(C)CCOCCCNC(=O)[C@H1]2CC[C@H1]2C C[C@H1](NC(=O)C1(C)CC(F)(F)C1)[C@@H1]2C[C@H1]2C(=O)NCCN(C)C3CC3 C[C@@H1](CNC(=O)C1=NC2=C(Br)C=NC=C2[NH1]1)N(C)C(=O)[C@@H1]3C[C@H1]3C4CCC4 C=CCO[C@H1]1CCN(C(=O)[C@H1]2CCCS2)C1 CCCC1=CC=C(C(=O)N[C@@H1]2C[C@@H1](C)CN(C(=O)CC3=CN=C(O)N=C3O)C2)S1 CC1=CC(CC(=O)N[C@@H1]2C[C@H1]3CN(C(=O)C4=CC=C5[NH1]C(=N)SC5=C4)C[C@@H1]32)=N[NH1]1 O=C(COC(F)(F)F)N1CCN(C(=O)C2=NC=CC=C2O)[C@H1](CO)C1 CC(=CC(=O)NCCN1C[C@@H1](CCO)OC1=O)C2=CC=C(F)C=C2 COC(=O)CCCONC(=O)C1=CC2(CN(C(=O)[C@]3(C)CNC(=O)N3)C2)OC1 CCC=1N=N[NH1]C=1C(=O)NC[C@@H1]2CCCN(C(=O)[C@]3(C)CC=CCC3)C2 CC(C)C1=CC=NC(N(C(=O)CN2C=CC=N2)[C@H1]3C[C@H1](N)C3)=N1 C[C@@H1]1C[C@@H1]1CC(=O)N2CCC[C@H1]([C@@H1]3C[C@@H1]3NC(=O)CC4=CC=C(C(C)(C)C)C=C4)C2 C[C@@H1]1COC[C@H1](CC(=O)N[C@@H1](CCF)C(=O)N(C)CC2=CC=NC=C2)O1 CN1N=CC([C@@H1](C(=O)NC[C@@H1]2CCCO2)N(CC=3C=CSC=3)CC4CC4)=C1Br COC1=CC(Cl)=CC(F)=C1CN2CC(F)(F)C[C@H1]2C(=O)N3CC4(CCCC4)C3 CC1=C[NH1]C(C(=O)N2CC3CCCC(C2)N3C(=O)C4=C(F)C=CC(C)=C4NO)=C1 CN1C=C(Cl)C(C(=O)NCC2(NC(=O)CC=3C=C[NH1]N=3)CCC2)=N1 CCC=1C=COC=1C(=O)N2CC[C@H1]3[C@@H1](C2)NC(=O)CN3C(=O)C4=CC=C(Cl)S4 CCCS(=O)(=O)CC(=O)N[C@@H1]1[C@@H1]2CCCN(C3=NC=NC(Cl)=C3CC)[C@H1]2C1(C)C C=CC[C@@H1](C)C(=O)NCCCN(CCO)C(=O)C12CC(N)(C1)C2 CSC(C)(C)C(=O)NCC1(F)CN(C(=O)C2=CC=CC3=NC=C(C)C=C23)C1 CCC[C@@](C)(O)C(=O)NC[C@H1](CO)NC(=O)[C@@H1](C1=CC=C(C)C=C1)C2CC2 CCCNC(=O)C1=CSC=C1C2=CC=C(C(=O)NOC)C=N2 CCCC[C@@H1](O)CCC(=O)N[C@H1]1CC[C@]2(CC1)CN(C(=O)C3(CC)CC3)CCO2 COC1=CC=C(COC2=CC=C(Cl)C=C2C(C)=O)C=C1F CC(C)N1C=CC(C(=O)N2CCC[C@H1](NC(=O)[C@@H1]3CCC[C@H1]3C(F)F)CC2)=N1 CC=1[NH1]N=C2C=CC(NC(=O)C[C@@H1]3COCCN3C(=O)CCCCBr)=CC=12 COC(=O)[C@H1](NS(=O)(=O)C=1C=CC(=NCC2=CSN=N2)[NH1]C=1)C3=CSC=N3 CC1=CC(O)=C(Cl)C=C1C(=O)NCCCCCNC(=O)[C@@H1](CN(C)C)C(C)C CCCN(CCCNC(=O)[C@H1](CC)CN(C)C)C(=O)C=1C=NN2C=1CCC2 CC1=NOC(C(=O)N(C)CCOCCCN(C)C(=O)C[C@@H1]2CCCC(=O)N2)=C1C CCCC1=NC(C)=C(C(=O)NC[C@@](C)(O)CNC(=O)C2=CC(C)=NO2)S1 CC1(C)C[C@@]1(NC(=O)C[C@@H1]2CCCC(=O)N2)C(=O)NC=3C=CC4=NC=NN4C=3 CC1=CC=CC(C(=O)N2CCN(CCNC(=O)[C@H1]3CCCC4=NN=CN43)CC2)=C1 O=C(CC=1C=NOC=1)NCC2=CC=CC=C2CNC(=O)C(O)(C3CC3)C4CC4 CN(CC1=NC=CO1)C2=CC=C(S(=O)(=O)N(C)CCC3=CN=C[NH1]3)C=C2F C#CC1=CC=C(CC(=O)N2CC[C@](O)([C@H1](F)C(=O)NC[C@H1](O)CF)C2)C=C1 CCN1N=CC=C1NC(=O)C=2C=NN3C=2CN(C(=O)C4=CC=C(F)C(F)=C4)CC3 CCCC=CC(=O)N1CC[C@@](NC(=O)CN2C=CN=N2)(C3=CC=CC(F)=C3)C1 CCN(CCCNC(=O)C[C@@H1]1CC[C@H1]1C2CC2)C(=O)C3=CC(C)=NN3C4CC4 CCC[C@@H1](CNC(=O)COCC(=O)NC)C(=O)NC[C@H1](C)C1=CC=CC=N1 CC1=CC(=NC[C@H1](C)C(F)F)[NH1]C(=NCC(=O)NCC(C)C)[NH1]1 CC(C)(C)/C=C/C(=O)NC[C@@H1](CO)NC(=O)CC1CC(F)(F)CO1 CC[C@@H1]1CN(C(=O)COCC(F)F)CC[C@@H1]1NC(=O)CC2=CC(O)=NC(O)=N2 O=C1CCC(C(=O)NC[C@@H1]2C[C@H1]2NC(=O)C3=CC(F)=C([N+1](=O)[O-1])C(F)=C3)=NN1 CCC[C@H1](O)CC(=O)NC1(COC)CN(C(=O)C2=CC=C(C(F)(F)F)C(C)=C2)C1 N#CC1=CC=CC(CCC(=O)N2CC[C@H1](CNC(=O)C34CC3C4)C25CC5)=C1 C#CCOC[C@@H1]1CCCN1C(=O)[C@]2(C)C[C@H1](O)CN2C(=O)C3=COC(COC)=N3 CC(C)CSCCC(=O)N1C[C@H1]2C[C@@]2(CNC(=O)[C@H1]3CCCC4(CC4)C3)C1 C#CCC(CC#C)C(=O)NC[C@]1(F)CC[C@H1](CNC(=O)[C@@H1](C)S(N)(=O)=O)CC1 C=C(C)[C@H1]1CN(C(=O)C2=CC(CNC(=O)CC[C@@H1](C)N(C)C)=NO2)CCO1 CC1=CC(=N[C@H1](C)C=2C=C(Cl)SC=2Cl)[NH1]C(=NCC3=CC=NC(Cl)=C3F)[NH1]1 C[C@@H1]1CCC(=CC(=O)N2CC[C@@H1](NC(=O)C3=CC=C4C=COC4=C3)C2)C1 COC1=CC=CC(N2CC[C@@H1](NC3(CSC4=CC=C(Cl)C=C4)CCC3)C2=O)=C1 COC1=C(C)C=C(Cl)C=C1C(=O)N[C@@H1](C)CNC(=O)C2=CC(C#N)=CS2 CC(C)[C@](C)(O)C(=O)N(C)CC1(CNC(=O)[C@@H1]2CN3CC4CC3(CO2)C4)CC1 CC1=CC=NC(C(=O)N2CCO[C@@H1](C(=O)N[C@@H1](C)C3(O)CCC3)C2)=C1F CNC(=O)NCCNC(=O)[C@@]1(CO)CCN(C(=O)[C@H1]2C[C@@H1]3CCC[C@@H1]3C2)C1 C=CC[C@H1](CNC(=O)C[C@@H1](NC(=O)[C@H1](C)N1CCNC1=O)C(F)(F)F)CC(C)C C[C@@H1]1CCC=2[NH1]N=C(C(=O)N3[C@H1]4CC[C@@H1]3C[C@@H1](NC(=O)CS(C)(=O)=O)C4)C=2C1 CC(C)=C=CC(=O)N1CC[C@H1](F)C[C@@H1]1C(=O)N2CCC[C@H1](C)[C@@H1]2CCO COC1=NC=C(C(=O)N(C)CCNC(=O)C2CC3=CC=CC=C3C2)N=C1C CC[C@H1]1CN(C(=O)C(CC)(CC)CNC(=O)[C@H1](C)N2CCOCC2)CC(=O)N1 NC1=C(F)C=CC(F)=C1C(=O)N2C[C@@H1]3C[C@H1]2[C@@H1]3CNC(=O)C4[C@@H1]5COC[C@@H1]45 CC1=CC=CC=C1NC(=S)NC2=CN=C3N=CC=CC3=C2 COC(=O)C1=CC=C(C=CC(=O)NC[C@H1](CO)NC(=O)CP(C)(C)=O)O1 CC=1OC=CC=1C(=O)NC[C@H1]2CN(C(=O)C=3SC=CC=3Br)C[C@@H1]2N(C)C CC[C@H1]1C[C@@H1]1CC(=O)N[C@H1](CNC(=O)CCN2C=NC=N2)CC(C)C CCCC[C@H1](CC)CCC(=O)N[C@@H1]1CC[C@H1]1NC(=O)C[C@@H1]2CCC(C)(C)CO2 CCN(C[C@@H1](C)NC(=O)[C@@H1](C)N1C=CC(C2CC2)=N1)C(=O)C3=C[NH1]C=C(C)C3=O CCCCN1C=C(CN2CCOCC[C@H1]2C3CC3)C=N1 COC1=CC=NC=C1CNC(=O)[C@]2(C)C=CCN2C(=O)C34C(=O)C5C[C@H1]3[C@H1]4C5 CC1=CC(C(=O)NCCCC[C@H1](C)NC(=O)C2=C(C)C=C(Cl)C=C2[N+1](=O)[O-1])=CS1 CC1=NO[C@H1](CC(=O)N[C@H1](C)CCNC(=O)COC2=CC=CC(C(C)C)=C2)C1 C[C@H1](O)C(=O)N[C@]1(C)C[C@H1](C(=O)N2CC[C@@H1]2C(N)=O)C1 C[C@@H1](C(=O)N[C@H1](C)C[C@@H1](C)NC(=O)C1=CC=CC2=C1CCO2)N3C=CC=N3 CC(=O)CCCC(=O)NCC1(C(=O)NCCCCN2CCCC2)CCC1 C[C@@H1]1CCN(C(=O)CC2=NC(C3CC3)=CS2)C[C@H1]1NC(=O)[C@@H1](O)C4CCC4 CC1=CC(=NCC2=CC=C(Br)C=C2C)[NH1]C(N[C@H1]3CCO[C@H1](C)C3)=N1 CCN(C(=O)[C@H1](F)CC1CCCC1)[C@H1]2CCCN(C(=O)C3=CC=CC(N)=C3C)C2 N#CC1=CC=C(CN=C2[NH1]C(=NCCSC3=CC=CC=N3)[NH1]C4=C2CCC4)C=C1 CN(C1=NC(C#N)=NC2=CC=CC=C12)C3C[C@@H1]4CC[C@H1](C3)N4 CCCC1=CC(C(=O)N2C[C@H1](C)C[C@@H1](NC(=O)[C@H1](CC)CCOC)C2)=NN1C C=CC[C@H1](C)C(=O)NC=1C=CC(=NCC2=CC=C(F)C(C(C)(C)C#N)=C2)[NH1]C=1 CN1N=NN=C1[C@@]2(NCC3=CC=C(CO)C(F)=C3)CCC[C@@H1](N(C)C)C2 CCOCCC(=O)NC1(CN=C2C=C(F)N=C[NH1]2)CC1 CC(C)(C)C[C@H1]1CCCN1CC2=CN(C3=CC=CC(C#N)=C3)N=N2 CCCCCCCCS(=O)(=O)N[C@H1]1COCCN(C(=O)C=2N=CSC=2C(C)C)C1 C=CC[C@H1](CNC(=O)C1=COC=N1)C(=O)NCCC=CCCC CC1=CC=C(C)N1CC(=O)N[C@H1]2CCCN(C(=O)CN(C)C3=CC=C(Cl)C=C3)C2 CC[C@H1](C)CC(=O)NC[C@H1]1CCC2(CN(C(=O)C[C@@H1](O)C3=CC=C(F)C=C3)C2)O1 C=CCCCCCCC(=O)N1C[C@@H1](C)[C@@H1](NC(=O)CNC2=CC=C(Cl)C=C2)C1 CCCC=CCCNC(=O)[C@H1]1CCCN(C(=O)COCCCC(C)C)C1 COCCCS(=O)(=O)NCC(=O)N(C)[C@H1]1CCN(C(=O)CN2CC(C)(OC)C2)C1 C[C@@H1]1C[C@H1](NC(=O)C2=CC(O)=C(F)C=C2N)CCN1C(=O)C=3C=NN(C)N=3 CCCN(CCN(C)C)C(=O)[C@@H1]1C[C@@H1](O)CN1C(=O)CCCSC CCN(CC(=O)N1CCC(F)(F)[C@H1](CNC(=O)C=2C=C(Cl)SC=2Cl)C1)C3CC3 CC=1N=C(C(=O)N2CCN(C(=O)[C@H1](C)C3=CC=CC(O)=C3)C[C@@H1]2CC)SC=1C CC(F)(F)CN1CCN(C(=O)C2=CC(Br)=C(F)C=C2F)CC1 CC[C@@H1]1[C@@H1](NC(=O)C2=CSC=3N=NSC2=3)CCN1C(=O)C=4C=C(C)OC=4C CCN=C1[NH1]C=NC2=CC(C(=O)NCCNC(=O)C[C@@H1]3CCCC(=O)N3)=CC=C12 CON=CC(=O)N[C@@H1]1CN(C(=O)[C@]2(C)C[C@H1]2C)CC(C)(C)C1 CC1=NC(C(=O)N2CCC[C@H1]2CNC(=O)[C@@H1](C)[C@@H1](C)O)=CN1 COC1=CC=CC=C1OCC(=O)N[C@H1]2CS(=O)(=O)C[C@H1]2NC3=NC=NC(C)=C3Br CC[C@@H1](CC(=O)NC1(C(=O)N2CC(N(C)OC)C2)CC(F)(F)C1Cl)CN(C)C CN1N=CC(NC(=O)[C@]2(O)CCN(C(=O)COC(C)(C)C)C2)=C1C#N CCCCC=1OC=NC=1C(=O)N2CC3(C2)CN(C(=O)C4=CC(Cl)=NC=C4N)C3 CC(C)[C@@]1(C(=O)NCC2=CN=N[NH1]2)CCN(C(=O)C=CC(=O)NC3CC3)C1 CCCCN(CC)C(=O)[C@]1(NC(=O)C2=C[NH1]C3=CC=CN=C23)CCC[C@@H1]1C CC(C)(C)[C@@H1]1CC(C(=O)N[C@H1]2CN(C(=O)[C@H1]3CNC(=O)N3)C4(CCOCC4)C2)=NO1 CC1=NC(C(=O)N2CCC[C@H1]([C@H1](C)C(=O)N(C)[C@@H1](C)CN(C)C(C)C)C2)=CO1 C[C@@H1](CN(C)C(=O)[C@H1]1C[C@H1]1CN(C)C)N(C)C(=O)C2=CC=C3C=NC=CC3=C2 C[C@H1](CN=C1[NH1]C(=NC[C@H1]2CCN(C)C2)C3=CC=CC=C3[NH1]1)CC(F)(F)F CC1=CC(C)=C(C(=O)N2C[C@@H1]3C[C@H1]2[C@H1](N(C)C(=O)C4=CC=C(Cl)C=C4)C3)C(C)=N1 CC1=C(C(=O)NC[C@H1]2CN(C(=O)C3=CN=C4N3CCS4)C5(CCOCC5)C2)CC1 C=CC[C@H1](CC(C)C)C(=O)N1CCC(NC(=O)C2=CC=C(OC(C)C)C=C2)CC1 CC1=C(C(=O)N2C[C@H1]3[C@H1](CNC(=O)C4CN(C)CCN(C)C4)[C@H1]3C2)C=CN1C C[C@@H1]1C[C@H1](C(=O)N2CC(CNC(=O)C3=CC=C4C=CSC4=C3)C2)CC(C)(C)C1 CSC1(C(=O)N2C[C@@H1]3CC(NC(=O)[C@@H1]4CCCN5C=C(C)N=C54)C[C@H1]3C2)CC1 C[C@H1]1CCC[C@@]1(C)CNC(=O)[C@@H1]2C[C@H1](NC(=O)CC3=CC=CO3)CCO2 CC[C@@H1](C)C[C@@H1](C)C(=O)NCC(C)(C)CC1CN(C(=O)[C@H1]2C[C@H1](S(C)(=O)=O)C2)C1 CC1=NO[C@@H1](C(=O)NC[C@@]2(F)CCCN(C(=O)C3=CC(C)=C(C)C(C)=C3)C2)C1 CC1=CC=C(CC(=O)N2CC[C@@H1](C(=O)NC3=CC=CC(Cl)=C3O)[C@@H1](O)C2)C=N1 CCN=C(NCC1=CC=C(F)C2=C1CCCC2)N3CCC(C#N)(COC)CC3 C[C@@H1](CCCNC(=O)OC(C)(C)C)NC(=O)C(=O)N(C)[C@H1]1CCC2=CC=CC=C21 CC1=CC=CC=2C(=O)N(CC(=O)N3CC(N(C)C(=O)CC4=CN=NS4)C3)C=NC1=2 CCN1N=C(C)C=C1C(=O)NC[C@@]2(O)CCCN(CC3=CC=CC(OC)=C3O)C2 C[C@H1](CC1=CN=CO1)C(=O)N(C)CCCCCCNC(=O)CCOCC(F)F O=C(NC[C@]1(O)CCN(C(=O)[C@@H1]2CCC=3N=C[NH1]C=3C2)C1)C4=CC=C(CF)C=C4 CCCCSCC(=O)NC[C@@H1]1C[C@@H1](C)N(C(=O)CC[C@@H1]2CC[C@H1](C(F)(F)F)O2)C1 C/C=C/C[C@H1](NC(=O)[C@@H1](F)C(C)C)C(=O)N[C@@H1](CO)CCOC C=C[C@H1]1CN(C(=O)C2=CN=CC=C2N(C)C)C[C@H1]1NC(=O)[C@H1]3CCCOCC3 CC[C@@H1](CC(=O)N[C@H1]1C=CCCC1)N(C)C(=O)[C@@H1]2C[C@H1](F)CN2C C=CC[C@@H1](C(=O)NC[C@H1]1C[C@@H1]1CNC(=O)C=2C=C(C)[NH1]C(=NC)N=2)C3CC3 CCC1=NC(C(=O)N[C@@H1]2[C@@H1]3CCCN(C(=O)CS(N)(=O)=O)[C@@H1]3C2(C)C)=CO1 CC1=CC(Br)=C(F)C=C1C(=O)NC2=CC=CN=C2C(=O)NC3=CC(I)=CC=C3F CO[C@H1](C(C)C)[C@H1](O)C(=O)NC(C)(C)CCCNC(=O)[C@H1]1CC=C(C)CC1 C=C(Br)CCC(=O)NC[C@@H1](NC(=O)[C@H1](O)C=CC)C1=CC=CC(C)=C1 CCC1=NOC=C1C(=O)N[C@H1](C)[C@H1](NC(=O)C=2SC=CC=2CO)C3=CC=CC=C3 CCN(C[C@@]1(O)CC2CCC1CC2)[C@H1]3CCCC4=CC=CN=C43 CN(CCN(C)C(=O)C1(C2=CN=CS2)CC1)C(=O)C3=CC=C(Cl)C=C3F CC1=CSC=2C=C(C(=O)NCC[C@@H1](C)N(C)C(=O)C3=CC=C(Br)C=N3)[NH1]C1=2 COCC1(CC(=O)N2CC[C@@](CO)(CNC(=O)[C@@H1]3C[C@H1]4CC[C@H1]3C4)C2)CC1 CCCCCS(=O)(=O)CC(=O)NC[C@@H1](C)NC(=O)[C@H1]1C[C@H1]2CC[C@H1]1O2 CN(C)C[C@@H1]1CC[C@H1](C(=O)N(C)C[C@@H1]2COCCN2C(=O)C=3C=NN(C)C=3)O1 CC1=CC=C(C(=O)N2CCC(C)(C)[C@@H1](NC(=O)C(F)=C(C)C)C2)C(O)=C1 CP(C)(=O)C1CCN(CCCNC(=O)C2=CC=NC=C2)CC1 CC1=NC2=CC=NN2C(C)=C1CCC(=O)N[C@H1]3CCC[C@H1](NC(=O)C=4C=CSN=4)C3 CC1=C(C(=O)N[C@@H1]2CC=C(C(=O)NCC3=CN=CC=N3)C2)COCC1 C[C@]1(C(=O)OCC(=O)CCC2=CC=CC=C2)C[C@H1](C3=CC=CC=C3)CO1 NC(=O)C(=O)N1C[C@H1](CO)[C@H1](NC(=O)C2=CN=CC(F)=C2)C1 CC1=CN=C2C(C=NN2CC(=O)N3CC[C@](NC(=O)CS(N)(=O)=O)(C4CC4)C3)=C1 CC1=NC(C(=O)NCC[C@@H1]2CCN(C(=O)C34CCC(F)(CC3)C4)C2)=C(C)O1 CC1=CN=C2C(C(=O)NC[C@@H1]3CCN(C(=O)C4=CC=CN=C4)C[C@@H1]3C)=CC=CN12 CC=1N=C(C2=CC=CC=N2)SC=1C(=O)N[C@@H1]3CC34CC(NC(=O)[C@H1](C)CF)C4 CCCOC1=CC=CC(C(=O)N(C)C2CN(C(=O)C3=CC(C)=C(CO)C=N3)C2)=C1 CC1(C)CSCCN(C(=O)NCC2=CC=CC(C(C)(C)C)=C2)C1 O=C(CN1C=NC(C(F)(F)F)=C1)NC[C@H1]2C[C@@H1]2NC(=O)C3=CC=CC(C(F)F)=N3 CC1=NO[C@](C)(C(=O)N2CCN(C3CN(C(=O)C[C@H1]4CC=CCN4C)C3)CC2)C1 CC1(C)[C@H1]2CC[C@@H1](C2)[C@@H1]1C(=O)N[C@]3(C)C[C@H1](NC(=O)C4(C5CCCCC5)CC4)C3 C=C(C)CC(=O)N1CCC[C@H1]2[C@@H1]1CCN2C(=O)[C@H1](C)OC3=CC=C(Cl)C=C3CO C[C@H1]1C[C@H1]1C(=O)N[C@H1]2C[C@@H1]3C[C@H1]2N(C(=O)C4=CC=CC5=CC=C(Br)N=C45)C3 CO[C@H1](CNC(=O)[C@@H1](F)CCC(C)C)CN(C)C(=O)CCN1C=CC=NC1=O CC1(C)COCC[C@H1]1CNC(=O)[C@H1]2CC23CC(NC(=O)C(F)(F)CO)C3 CCN(CC)C(=O)CN1CCN(S(=O)(=O)[C@H1]2COC3=CC=C(Br)C=C32)CC1 C[C@H1](CNC(=O)N[C@H1]1C(=O)NC2=CC(Cl)=CC=C21)C3=CC=CC=C3[N+1](=O)[O-1] O=C(N[C@H1]1CCN(C(=O)C2=CC=CN=N2)CC13CCC3)[C@@H1]4CC5=NN=CN5C4 CCC[C@H1](NC(=O)[C@H1]1[C@@H1]2C[C@H1]1CN2C(=O)C[C@]34CCC[C@H1]3C4)C(=O)N(C)C CCCN(C(=O)C1=CC=NN1C)C2CCN(C(=O)[C@H1](C)[C@@H1]3CCC(=O)N3C)CC2 COC1=CC(C)=C(C(=O)N[C@H1](C)C[C@H1](C)NC(=O)[C@H1](C)N2C=C(Cl)C=N2)C(F)=C1 COC1(C(=O)N2[C@H1](CNC(=O)C[C@@H1](C)C(C)C)C[C@@H1]3COC[C@@H1]32)CCOCC1 CC(C)N1CCN(C(=O)[C@@H1]2[C@H1](O)CCN2CC3=CC=CC(I)=C3O)[C@@H1](C)C1 CSC1(CNC(=O)COC2CN(C(=O)C3=NC=NC=C3Cl)C2)CCC1 CC=1[NH1]C(=N)SC=1C(=O)N(C)[C@H1]2CCN(C(=O)C[C@H1]3NC(=O)C4=CC=CC=C43)C2 CN(C(=O)CCC1=NC=CN1C)[C@H1]2CC[C@@H1](NC(=O)[C@H1]3C[C@@]4(CC4(F)F)C3)C2 CC(C)(C)SCCCC(=O)NC[C@@H1]1CN(C(=O)C=CC=2C=N[NH1]C=2)CCCO1 CCN1CC[C@H1]1C(=O)N2CC(CCNC(=O)CN3CC=CC3)C2 CC1=CC(Cl)=CC(C)=C1OCC(=O)NCCC2(NC(=O)C3=CSC=N3)CCC2 O=C(CC1=N[NH1]C2=CC(C3=CN=C(C4CC4)N=C3)=CC=C12)N5C[C@H1]6C[C@H1]6C5 COC1=CC=NC(F)=C1C(=O)N(C)CCNC(=O)C2CCC3(CCC3)CO2 C=C[C@H1](C)CC(=O)N1C[C@@]2(CNC(=O)C[C@H1]3CCC(C)(C)C3)C[C@H1]1CO2 CC1=CC(C)=C([C@@H1](C)NC(=O)N[C@H1](C)CCC(F)F)C(C)=C1 CC1=NC=C2CC(C3CN(C(=O)CC[C@H1]4CC[C@@H1](O)CC4)C3)=CN12 C[C@H1](N)[C@@H1](C)C(=O)N[C@@H1]1CCN(CCF)C1 CC=C(F)C(=O)N[C@H1]1C[C@@](C)(NC(=O)C=2C=NN([C@H1]3CCOC3)N=2)C1 COCC(=O)N[C@H1](C)C(=O)N[C@@H1]1CN(C(=O)C=CC=2SC=NC=2C)C[C@H1]1O O=C(CCC1OCCO1)N[C@@H1]2C[C@H1](O)[C@@H1](NC(=O)[C@H1]3C[C@@H1]3[N+1](=O)[O-1])C2 CC[C@@H1](O)CC(=O)N1CCN(CC2=CC=CC(C(=O)O)=C2)[C@@H1](CC)C1 N#CC1=C(NCCOCCNC(=O)C2[C@@H1]3CCC[C@@H1]23)N=NC4=C1CCCC4 CN1N=CN=C1CCC(=O)N2CCC[C@]23CCCN(C(=O)C=C[S@](C)=O)C3 C#CCCN(C)CC(=O)NC[C@@H1]1OCC[C@@H1]1C(=O)N[C@@H1](C)C=2N=CN(C)N=2 NC1=CC=C(Cl)N=C1C(=O)NC23CC(NC(=O)[C@H1]4CC5(CC5)CO4)(C2)C3 CCNC(=O)[C@H1](CC1=CC=C(O)C=C1)N2CC[C@H1]3CC[C@H1](O)[C@H1]2C3 C=C[C@H1](CC)CC(=O)N1CC2=CC=CC=C2[C@H1]1CNC(=O)[C@@H1]3CC[C@H1]4C[C@@H1]3CO4 COC=1C=C(C)SC=1C(=O)N2CC=C[C@@H1](NC(=O)[C@@H1]3CCCCNC3=O)C2 CO[C@@H1]1C[C@H1](CNC(=O)C2=NC=CN3N=C(C)C=C23)N(C(=O)CCCCC#N)C1 CCC1=NN=C2C=C(N[C@@H1](CNC3=NC=C(Br)C=C3C#N)C4CC4)N=CN12 C=CCC(=O)NC[C@H1]1CCC2(CO1)CC(NC(=O)[C@]3(F)CC=CCC3)C2 CC1=NN=NN1CC(=O)N2C[C@@H1]3[C@@H1](CCC[C@H1]3NC(=O)CCC=4C=NN(C)N=4)C2 CC(C)(C(=O)N[C@@H1](CC1=CC=NC([N+1](=O)[O-1])=C1)C(=O)O)[C@H1]2CCCOC2 CC=1[NH1]C(C)=C(C(=O)N2CC(O)(C3(CNC(=O)C(C)(C)[C@@H1](C)O)CC3)C2)C=1C CN1CC[C@H1](CC(=O)N[C@@H1](CC(=O)NC2(C)CC(O)C2)C(F)(F)F)C1=O CC[C@](C)(O)C(=O)N1C[C@@H1](NC(=O)C2=CC=CN2C)[C@H1](C(F)(F)F)C1 C[C@H1](C(=O)NC[C@H1]1CCCCN1C(=O)[C@@H1]2[C@H1]3[C@H1]4C[C@H1]2C(=O)[C@@H1]34)C5=CC=CN=C5 CC[C@H1](C(=O)N(CCN(C)C(=O)C(F)(F)C1=CC=C(Cl)C=N1)C(C)C)[C@H1](C)O CC(C)(C)OC(=O)N1CC(C(=O)NC[C@@]23C[C@@H1]2CN(C(=O)C4=CC=C(I)C=C4)C3)C1 COC1=NC=CN=C1C(=O)N[C@H1](C)CC(=O)NCCOCC(N)=O CN=C1[NH1]C=C(C(=O)N[C@]2(C(=O)N3CC[C@@H1](CCCO)C3)C[C@H1](O)C2)O1 N[C@H1]1CN(C(=O)C=C2N=CN(O)C3=CC=CC=C32)CC14CCC4 O=C(N[C@@H1]1CO[C@H1]2CCCC[C@H1]12)NC3(CC4=CC=C(F)C=C4)CC3 COC=1C=C(C(=O)NC2=CC=CC(NC(=O)[C@H1]3C[C@H1]3C4=CC=CS4)=C2)[NH1]N=1 CC1=CC=C(S(=O)(=O)N2CC[C@H1](CC3CNC3)C2)C([N+1](=O)[O-1])=C1 CC=CC=CC(=O)N[C@H1](C)CCCC(=O)NCCC1=CN=C(C)C=N1 CC(C)C1=N[NH1]C=C1C(=O)NC[C@H1](C(=O)N2CC[C@](C)(O)[C@H1](O)C2)N(C)C COCCN(CCNC(=O)[C@H1]1CCCC2=CC=C(OC)C=C21)C(=O)CN(C)C CCC(CC)C(=O)NCC1=CC=CC=C1CNC(=O)[C@H1](OC)C(C)C O=C(C=CC1CC1)NC[C@]2(F)C[C@@H1](CNC(=O)C3=CC=C([N+1](=O)[O-1])C=C3)C2 CCOCC1(C(=O)N2[C@@H1](C(=O)NOC[C@@H1]3CCOC3)CCC24CC4)CCC1 C[C@H1]1C[C@@]1(NC(=O)[C@H1](O)CN2C=NC=N2)C(=O)NOC[C@H1](O)CO O=C(NCCOCCCNC(=O)C1OCCCO1)C23CC(CO)(C2)C3 CCCN(CC(=O)N1CCC[C@H1]1CCC)C(=O)COCC2CCCC2 C[C@@H1](CNC(=O)[C@@H1](C1CCC1)C(C)(C)C)CNC(=O)C2=CC=C(P(C)(C)=O)C=N2 CCC[C@@H1](NC(=O)C=1SC(F)=CC=1C)C(=O)NCC2=CC(=O)C=C[NH1]2 COC1=CC=CC=C1C=2SC(NC(=O)C3=CC=C4N=C(N(C)C)[NH1]C4=C3)=NC=2C CCO[C@H1](C(=O)N[C@H1]1CCN(C(=O)C2(CC)CCC(O)CC2)C[C@H1]1F)C(C)C O=C(NC1=NC=CC(Br)=C1F)[C@@H1]2CCN(CC3=CC=C(Br)C=C3[N+1](=O)[O-1])C2 C#CCC[C@H1](NC(=O)[C@H1](O)CN1CCCC1)C(=O)NCCN(C)C2CC2 CCS[C@@H1](C)C(=O)N1CCC[C@H1]1CN(C)C(=O)C2=CN(CC)C=N2 C=CC[C@@H1](C)C(=O)N(CCCNC(=O)CCC=C(C)C)C1CCCC1 COC[C@@H1](F)CNC(=NCCSC)NCC1=CC=C(C2=NN=CN=N2)C=C1 C=CCCC[C@@H1](NC(=O)CCC(=O)NC)C(=O)NC[C@]12CO[C@H1](C1)[C@H1](O)C2 C[C@@H1](NC(=O)COC=1C=CSN=1)C2CC(NC(=O)[C@@H1]3CC4(CCO3)CC4)C2 COC(=O)C12CC(C(=O)N3C[C@H1](C)[C@H1](NC(=O)C[C@H1]4CCCC[C@H1]4C)C3)(C1)C2 NC(=O)[C@@H1]1C[C@@H1]1C(=O)N2CCC(CNC(=O)C3=CN=N[NH1]3)CC2 C=CC[C@@H1](CNC(=O)[C@@H1]1C[C@@H1](F)C(=O)N1)NC(=O)C2=CC3=CC=CC(Cl)=C3[NH1]2 CSC1=CC=C(C(=O)NCCC2=CCN(C(=O)CC[C@@H1]3CCC(=O)N3)CC2)C=C1 CC(C)C(=O)N1CC(=O)N(CCC=2N=NN(C3CCCC3)N=2)N1 COC1=CC2=C(C=C1OC)CC(C(=O)NC3=NC4=C(S3)CO[C@@H1](CO)C4)C2 CCC1(NC(=O)[C@H1]2C[C@@H1](O)C2)CN(C(=O)C=3C=COC=3Cl)C1 CCN1N=C(C)C=C1C(=O)N2CCCC[C@@H1]2CN3C=C(C4=CN=C(OC)S4)N=N3 CC1=CC=NC(C(=O)NC2CC3(CCN(C(=O)CO[C@@H1]4CCOC4)CC3)C2)=C1N CCN1C=CC(C(=O)N2C[C@@H1](O)[C@@H1](CNC(=O)C3=C[NH1]C4=NC(F)=CC=C34)C2)=N1 C[C@@H1](CC1CN(C(=O)CSC(F)F)C1)NC(=O)[C@@H1]2CCCCC2(C)C CN1N=CC(Cl)=C1CC(=O)N[C@]2(CF)CCN(C(=O)C[C@]3(C)CCCO3)C2 CC1=CSC(C(=O)N2CC[C@@H1](NC(=O)C3=CC=C(C)C(Cl)=C3F)C[C@@H1]2C)=C1Cl CSCC[C@@H1](O)C(=O)N[C@@H1]1CN(C(=O)COC=2C=NN(C)C=2)CCC1(C)C CC=1C=CN([C@@H1](C)C(=O)NC[C@@](C)(O)CNC(=O)C2=CC=C(O)N=C2C)N=1 CC1=CC=CC=C1[C@H1](C)C(=O)N(CCNC(=O)[C@H1](O)C(F)(F)F)C(C)C O=C(N[C@H1]1CN(C(=O)CN=C2C=C[NH1]C=C2)CC13CC3)C4=CC(Cl)=CC=C4F CCC1(C(=O)N[C@H1](C)[C@@H1]2CN(C(=O)C=CCOC)CCO2)CCC1 CC[C@@H1](C)C(=O)NCCCCCCN(C)C(=O)CCCC1=CC=C(F)C=C1 CCC[C@H1](O)CNC(=O)[C@@H1]1N(C(=O)CC2CCN(C)CC2)CC13CCCC3 CNC=1SC=NC=1C(=O)N(C)CCN(C)C(=O)[C@@H1]2[C@H1]3[C@@H1]4CC[C@@H1](C4)[C@H1]32 C[C@H1](CC(=O)N[C@H1]1C[C@H1]2C[C@@H1]1CN(C(=O)C3=CCCCO3)C2)CN(C)C CC(C)=C(C)CC(=O)N1CC(C)(C)C[C@@H1]1C(=O)NC2(C)CCC3(CC3)CC2 COC(CNS(=O)(=O)C=C1N=C(N[C@@H1]2CCOC3=CC=CC=C32)C(Cl)=C1)OC CCN1CCN(CC2CC(OCCCCOC)CC2)[C@@H1](C)C1 CCCCCCCC[C@H1](O)CCC(=O)NCC1(NC(=O)C2=N[NH1]C=C2C)CCC1 O=C(NC[C@H1]1CCCN(S(=O)(=O)C2=CC=C(C(F)(F)F)[NH1]2)C1)C3=CC=CS3 C=CCCN1C=C(C(=O)N2CCC[C@@H1]2CCNC(=O)[C@H1](C(C)C)C3CCC3)N=N1 O=C(NC1CC(C2=CN(C3=CC=CC=C3[N+1](=O)[O-1])N=N2)C1)[C@H1]4CC5CCC4CC5 CC1=CC=CC(Cl)=C1S(=O)(=O)NCC[C@@H1]2CCCN(C(=O)C3CC(C)(C)C3)C2 CO[C@@H1](C)C(=O)N[C@H1]1CCCN(C(=O)/C=C/C2=C(Cl)C=CC3=CC=CC=C23)CC1 CC[C@@H1](NC(C)=O)C(=O)N1CC2(CN(C(=O)C3=CC=CC4=CN=NN34)CCO2)C1 CNC(=O)[C@H1](C1=CC=C(NC(C)=O)C=C1)N2C[C@@H1](C(=O)OC)C[C@@H1](C(C)(C)C)C2 CCOC[C@H1](C)C(=O)NCC1(O)CC(C(=O)N2C[C@@H1](C)O[C@@H1](C(N)=O)C2)C1 CCCC[C@@H1](F)C(=O)N(C)[C@](C)(C(=O)N(CC)CC1=CC=NC=C1)C2CC2 CC1=NC=C(C(=O)NC[C@](F)(C(=O)N(C)[C@H1]2CC[C@H1](CO)CC2)C(C)C)O1 CSCCCCCC(=O)N1C[C@H1]2C[C@]2(CNC(=O)C=3C(C)=NSC=3C)C1 CN(C)CCN(C)C(=O)NCC1=NN=C2C(Cl)=CC=CN12 CC(C(=O)N[C@H1](CNC(=O)C1=CC=C(Cl)C(F)=C1O)CC(F)(F)F)=C2CCC2 CS[C@H1](C)C(=O)N1C[C@@H1]2CCN(C(=O)C3=CC(O)=NC(C(C)C)=C3)CC[C@@H1]21 C[C@@H1](C(=O)N1CC(NC(=O)CNC(=O)C2=CC=CO2)C1)C3=CC=C4C(=C3)OCO4 CC1=NC=C(C(=O)N2CC[C@H1]([C@H1](C)C(=O)NC[C@@]3(C)CCC(=O)N3C)C2)C=N1 CCC1=NOC(CCCC(=O)N2CC[C@@H1](NC(=O)[C@H1]3CC4=NN=CN4C3)C2)=N1 CC(C)S(=O)(=O)[C@H1](C)C(=O)NC[C@]1(F)C[C@@H1](NC(=O)[C@H1]2CCC(C)(C)OC2)C1 C[C@H1](C(=O)N1CC([C@H1](C)NC(=O)CC2=CC=C(Cl)C=N2)C1)C3=CC(F)=CC(F)=C3 CC1=CC=C(C#N)C=C1C(=O)NC2=CC=CC(CNC(=O)[C@@H1]([C@@H1](C)O)N(C)C)=C2 COC1=CC=CC=C1CC(=O)N[C@H1](C)C2CN(C(=O)C3=CN=NC(C)=C3C)C2 CC[C@H1](C(=O)N1CCN(C(=O)C2=CC=CC=C2I)CC13CC3)N4C=CN=C4 CC[C@]1(C)CC[C@H1](CNC(=NCC2=NC(C(C)(C)C)=NO2)NCC(=O)NC(C)C)O1 CC1=CC(C(=O)N2CC[C@H1](C)[C@H1](NC(=O)[C@H1](O)C3CCCC3)C2)=NN1C(C)(C)C C#CCCCCCCC(=O)N[C@H1]1CCC[C@@H1](NC(=O)C2=COC(SC)=C2)C1 C[C@H1](CCCNC(=O)C[C@@H1]1CCCC(=O)N1)NC(=O)CNC(N)=O CC=1SC(O)=NC=1C(=O)NCC=2N=COC=2C3CN(C(=O)C4(CCCF)CC4)C3 CSCCN(C)C(=O)C[C@H1](NC(=O)[C@H1](C)NC(=O)C1CC1)C(F)(F)F COC1=CC=CC(CC(=O)N[C@H1](C)[C@H1](C)NC(=O)[C@@H1]2[C@H1]3CC[C@H1]4[C@@H1](C3)C[C@H1]42)=C1Cl CN(C)C1CC2(CC(NC(=O)N[C@@H1]3C[C@H1]4CC[C@@]3(C)C4(C)C)C2)C1 CCC=1OC=C(C)C=1C(=O)N[C@@H1](CC)CN(C)C(=O)C[C@H1]2CCOC(C)(C)C2 C[C@H1]1CCN1CC(=O)N2CC[C@H1]3[C@@H1](C2)CN3C(=O)/C=C/C4=C(Cl)C=CC=C4Cl CO[C@H1](C)CN[C@H1](C1=CC=C(N2CCOCC2)N=C1)C3=NN=NN3CC4CC4 CC1=CC=C([C@H1](C)C(=O)NC[C@H1]2CN(C(=O)[C@@H1]3CCC4=CC=CC=C43)CCO2)O1 NS(=O)(=O)C[C@H1]1CCN(C2=NC3=C(F)C=CC=C3C(=NCC4(Br)CC4)[NH1]2)C1 COC1=CC=C(CNC(=O)[C@@H1]2CO[C@H1](CNC(=O)[C@H1](C)N3CCCC3)C2)C=C1 COC1=CC=C(C(=O)N[C@H1](CNC(=O)CC[C@H1]2C(=O)ON=C2C)C(C)C)N=N1 O=C(CN[C@@H1]([C@@H1]1CCCO1)C(F)(F)F)NCC2=CC=CC=C2 CC=C(C=CC(=O)NC[C@H1]1C[C@@H1](C)N(C(=O)CC2=CC=C(OC)C=C2OC)C1)CC CCCN1N=NN=C1[C@](C)(CC2(OC)CCC2)NC(C)(C)C3=NOC(C)=N3 CS[C@@H1]1CN(C(=O)C(=O)C2=CC=C(F)C=C2)C[C@H1]1NC(=O)C3=CC=NC=C3C CCC1=CC=CC=C1OCC(=O)N[C@@H1](C)C2CN(C(=O)C3=CN=C(C)C=N3)C2 O=C(NC1CCC2(CC1)CN(C(=O)CO)C2)C(=O)C3=CC(F)=CC(Cl)=C3 CN(C)C[C@@H1](CC(=O)NC1CC[C@H1](CNC(=O)C(C)(C)C(C)(C)O)CC1)C(F)F N#CC1=NC=CN=C1NCCCN2C=C(C(=O)NCC(=O)O)N=N2 C[C@H1](O)C(F)(F)C(=O)NCC[C@H1]1COCCN1C(=O)CNC(=O)C2=CC=CN=C2 O=C1CC[C@@H1](CC(=O)N2C[C@@H1]3CC[C@H1](C2)N3C(=O)[C@]45CCO[C@H1]4CCOC5)CN1 C[C@@H1]1OCCO[C@@H1]1C(=O)N[C@H1](CNC(=O)CC=2C=NN(C3CC3)C=2)C(C)(C)C CCC(=O)CCC(=O)N1CCC2(CCC(NC(=O)[C@H1]3CC4(CCO3)CC4)CC2)C1 CCC[C@H1](C)CC(=O)N[C@H1](CCC)CCCNC(=O)CSC1=CC=CC=C1 CC1=C(F)C=C(C(=O)N2CCC[C@H1]2C(=O)NC3=CC=CC=4C=C[NH1]C3=4)C(F)=C1F CC(C)[C@@H1](CNC(=O)C[C@@H1]1C[C@H1]1C(F)(F)F)NC(=O)C2=CC=NC(S(N)(=O)=O)=C2 C[C@@H1](O)C(F)(F)C(=O)N1C[C@@H1]2COC[C@H1](C1)C2NC(=O)C3=CSC4=C3CCCC4 O=C(C1=CC=C(Cl)C=C1O)N2CC3(CCN(C(=O)CCC=CBr)CC3)C2 CCSCC1=CC=C(C(=O)N2CCN(C(=O)[C@@H1](F)CC(C)C)[C@@H1](C)C2)C=C1 CC(C)(O)C(F)(F)C(=O)NCC1=CN(C2=CC=CC(Br)=C2F)N=N1 CC(C)[C@@H1]1C[C@H1]1C(=O)N[C@@H1]2CCC[C@H1]2CC(=O)N3CCC[C@](C)(O)C3 CCCN1CCCC[C@H1]1C(=O)NC[C@]2(F)CC[C@H1](CNC(=O)C3(C)CC3)CC2 COC1=CC=C([C@@H1](C)C(=O)N2C[C@H1](C)[C@H1](NC(=O)CCCC(C)(F)F)CC2)C=C1 CC1=NOC2=CC(C(=O)NCC[C@H1]3COCCN3C(=O)C4=CC=NN=C4)=CC=C12 CCC[C@@H1](F)C(=O)N[C@H1]1C[C@@H1]2CC[C@H1](C1)N2C(=O)CCC3=CC=C(F)C=C3F O=C(NCC[C@@H1]1CN(C(=O)C23COC(CF)(C2)C3)CCCO1)[C@H1]4CCC[C@@H1](O)C4 CC(C)(NC(=O)C=1SC=CC=1CNC(=O)C(N)=O)C=2C=N[NH1]C=2 CC[C@H1](C)CC(=O)NC[C@@H1]1CN(C(=O)CC2=CC=C3OC=CC3=C2)CC(C)(C)C1 O=C(NC1CC2(C1)CC(NC(=O)[C@@H1]3C[C@@H1]3CF)C2)C4=CC=5OC(Br)=CC=5[NH1]4 CCC1=NC(CN(C)C(=O)C=2[NH1]C(C)=C(C(=O)NCC3=CC=C(Cl)C=C3)C=2C)=CS1 CC[C@@H1](C(=O)N1C[C@H1]2C[C@H1](NC(=O)C3=CC(Cl)=CC=N3)[C@H1]1C2)N4C=CN=C4 COC1=C(C(=O)N2CC[C@@]3(CCCN(C(=O)C=CCO)C3)C2)OC4=CC=CC=C14 N[C@@H1](CC(=O)OCC1=N[NH1]C(CC2=CC=CC=C2)=N1)C3=CC=CC=N3 C[C@@H1]1CN(C(=O)C2=CC=NN=C2Cl)CC[C@H1]1NC(=O)[C@H1]3CCCCN(C)C3=O CCCN1CC[C@H1](CNC(=O)CCN(CC2CC2)C(=O)C=3SC=C(C)C=3C)C1 C=CCCC(=O)NCC1CC(NC(=O)CSC)C1 C=1C=CN2C([C@H1](C(=O)NCC3=CC=CC=C3)N4CCCOC[C@H1]4C)=CN=C2C=1 CC1=CC=C(CNC(=O)C(C)(C)[C@@H1]2CCN(C(=O)CN3CCCCCC3)C2)N=N1 COC1=CC=C([C@@H1](N)CC(=O)N[C@H1]2CCC3=CC(F)=CC=C32)C=C1Br CCC(=O)C1(C(=O)N2C[C@H1]3CC[C@H1]2C[C@@H1]3NC(=O)C[C@H1](C)C(F)F)CC1 CCC1=NC(=N)[NH1]C=C1C(=O)NCC[C@@H1](C)N(C)C(=O)CC2=CSC(C)=C2 COC1=CC=C(C(=O)N[C@@H1](CCC(C)C)C(=O)N(C)[C@H1]2CCOC(C)(C)C2)O1 CCN1N=NN=C1[C@H1](NCC2=NC=CN2C(F)F)C3=CC=C(OCCO)N=C3 CCN(C)CC(=O)N[C@H1]1CCN(C(=O)C[C@]2(O)CCOC3=CC=CC=C32)[C@@H1]1C C#CC1CCN(C(=O)C[C@@H1]2CCCN(C(=O)[C@H1]3CC4=CC=CC=C43)CC2)CC1 CC(C)[C@@H1](CNC(=O)C[C@H1]1CCC(=O)N1C)NC(=O)CCC2=CC=CN=C2 CN1N=CC=C(C(=O)N[C@]2(C)C[C@H1](NC(=O)[C@@H1]3C[C@@H1]4CSC[C@@H1](C4)C3)C2)C1=O CC[C@]1(C(=O)N(C)[C@@H1]C2CCN(C(=O)[C@H1]3CC(C(C)(C)C)=NO3)CC2)CC1(F)F C[C@H1](C(=O)NC(C)(C)CNC(=O)C1=CN=C2[NH1]C=NC=C12)S(C)(=O)=O CC(C)(CC(F)F)C(=O)N1CC(F)(CNC(=O)[C@@H1]2C(Cl)(Cl)C23CC3)C1 CCOC=C[C@@](O)(CNC(=O)NCC[C@H1](C)NC(=O)OC(C)(C)C)C(F)(F)F O=C(NCC(=O)N1CC(NC(=O)[C@H1]2C[C@](O)(C(F)(F)F)C2)C1)C3=CC=C(Cl)S3 CO[C@H1]1CCC[C@@H1]1C(=O)N2[C@H1](C(=O)N3CCO[C@@H1]4C[C@@H1]43)C[C@H1]5C[C@@H1]52 C/C=C/C[C@@H1](CC)C(=O)NC[C@H1]1[C@@H1]2CN(C(=O)/C=C/C3=CC=CC(F)=C3F)C[C@H1]12 CC1=CN=CC(C(=O)N2CCOC3(CN(C(=O)[C@@H1](C)NC=O)C3)C2)=N1 COC1=NN(C)C(Br)=C1C(=O)NCC2(C)CCN(C(=O)C3=CC=NC=N3)CC2 CCOC[C@@H1](NC(=O)CSCC(F)F)C(=O)NC1=CC=CN=C1CC C[C@](O)(CNC(=O)C=1C=C(C2=CC=CO2)[NH1]N=1)C3CCN(C(=O)CNC=O)CC3 CC=1SC(C)=C(C(=O)NC23CC(CNC(=O)[C@H1]4CCC(=O)N4C)(C2)C3)C=1C#N CN(C[C@@H1]1CN(C(=O)[C@]2(C)CNC(=O)N2)CCO1)C(=O)[C@H1]3CCC(C)(C)OC3 CN1C=CN=C1CCC(=O)N2CC[C@@H1](NC(=O)C34COCC(C3)C4)[C@H1](CO)C2 CCN(C[C@H1](C)NC(=O)C1=CCCCCC1)C(=O)[C@@H1]2C[C@H1]2C3=CC=C(C)C=C3 O=C(NCC[C@@]1(O)CCOC1)C2=CC(CNC(=O)[C@@]3(F)CCO3)=CS2 C[C@]1(C(=O)N[C@H1]2C[C@H1](NC(=O)C3=CC=C4OC=NC4=C3)C2)CCCNC1=O COCCN(CCNC(=O)C1=CC=CC=C1O)C(=O)C=C[C@@H1]2CCOC2 CCN(C[C@@H1]1CCCN(C(=O)CCN2C=C(C)C=N2)C1)C(=O)[C@H1]3CCN3CC C[C@H1](NCCC12CC(CCO1)C2)C(=O)N3CCCC[C@@H1]3C CC1(C)C(NC(=O)/C=C/CNC(=O)C2=C[NH1]N=C2C3CC3)C1(C)C CCC1(NC(=O)C2=CC=CC(Cl)=C2C)CCN(C(=O)[C@@](C)(O)COC)CC1 COC1=CC=C2C=CC=CC2=C1CN[C@@H1]3C[C@@H1]3C(=O)NC=4[NH1]N=C(SC)C=4C#N C[C@H1]1C(C(=O)N[C@@H1](C(=O)N[C@@H1]2CCC[C@@H1](C3CC3)C2)C4CC4)=NO[C@@H1]1C C1C=CC=CC1/C=C/C(=O)N[C@H1]2COCC[C@H1]2C(=O)N3CC4(CC(C(F)F)=NO4)C3=C CCC1=CN=C(C(=O)N[C@@H1]2CCC[C@@H1]2NC(=O)[C@]3(CC)CCCO3)S1 COC1=CC(Cl)=C(C(=O)NC2CC(NC(=O)C3=N[NH1]C4=C3CCC4)C2)C=C1OC CC1=NN=C(C(=O)NCCC[C@H1](C)NC(=O)C2=CC(C3=CC=NC=C3)=CC=N2)S1 CC1=CC=C(OCC(=O)N2CCCN(C(=O)C3=CN(C)C=N3)CC2)C(C)=C1 O=C(C[C@@H1]1CCS(=O)(=O)C1)NC[C@@H1](N=C2C=CN=C(Cl)[NH1]2)C3CCC3 C[C@H1]1CN(C(=O)C2=CC=CC3=CN=NN23)C[C@@H1](CC(F)(F)F)O1 CCO[C@@H1](CC(=O)NCCCC[C@@H1](C)NC(=O)CCCC1=NC(C)=NO1)C(C)C CCN1CCN(CC(=O)NC[C@H1]2CC3(CCN(C(=O)[C@@H1]4C[C@@H1]4C#N)CC3)CO2)CC1 C=C[C@@H1](O)C(=O)N1CC[C@@H1](CNC(=O)C=2C=CC3=NC(=N)[NH1]N3C=2)C14CC4 CCC[C@H1]1C[C@@H1]1NS(=O)(=O)C2=CC=CC(C(=O)N3CCC4=CC=C(C)C=C4C3)=C2 CCC(C)(CC)CNC(=NCCC(=O)NC)NC[C@@H1]1OCCC=2SC(F)=CC=21 CNC(=O)[C@@H1](C)CNC(=O)[C@@](C)(C1CC1)N(C)C(=O)C2=CC=C(OC)N=N2 C#CCC1(C(=O)NC[C@@H1]2CCN(C(=O)C3=CN=C(CO)N=C3C)C[C@@H1]2C)CC1 CC(C)(C(=O)N1[C@H1](C(=O)NCC2=CC=CN=C2N)C[C@H1]3C[C@H1]31)C4=CC=CC=C4 C[C@H1]1C[C@@H1](C(=O)N[C@H1](C)[C@@H1](C)CO)N(C(=O)C2=CC=C(F)C=C2F)C1 CS(=O)(=O)CCCC(=O)N1CC(C2CN(C(=O)C3=CSC(C(F)F)=C3)C2)C1 C[C@@H1]1CN(C(=O)[C@@H1](NC(=O)[C@@H1]2C[C@@H1]2Cl)[C@@H1](C)O)CC[S@@]1=O CCC[C@@H1](C)CNC(=O)[C@]1(F)CCCN(C(=O)CSCCC(C)C)C1 CC=C(F)C(=O)N1CCC[C@]2(C[C@@H1](NC(=O)C=3C(C(F)(F)F)=COC=3C)CO2)C1 CC1=NN([C@@H1](C)CNC(=O)C2(Br)[C@H1](C)[C@H1]2C)C(C)=C1[N+1](=O)[O-1] COC1=CC=CC(OC(F)(F)F)=C1C(=O)NCCNC(=O)C=2C=CN3C=CSC=23 CC[C@H1](C)C[C@@H1](NC(=O)C[C@H1]1CCCOCC1)C(=O)N2CC3=CC=C(C)N=C3C2 C[C@@H1]1C2=CC=CN=C2CCN1N3CC(F)(F)C[C@@H1]3CC#N CC(C)CC1=CC=C(C(=O)CCC(=O)N(CC2=CC=CC=C2F)C3CC3)C=C1 CC(C)(C)C1=CN=C(COC(=O)C2=CN=CN2C3=CC=CC=C3)O1 C[C@@H1]1CC(=O)NCCN1C(=O)CC(C)(C)NC(=O)CC[C@H1]2CCCOC2 CC1=CC=C(OCC(=O)N[C@@H1](CO)CNC(=O)[C@H1](C(C)C)N2CCCCC2)C=C1 COCC1=NSC(NCC23CC(NC(=O)[C@@H1](O)C(C)(C)C)(CO2)C3)=N1 C[C@@H1](CO)C(=O)NC1CC(C)(C(=O)N(CCCO)CCCO)C1 COC1=CC=C(C(N)=O)C=C1C(=O)N(C)[C@@H1]2CCCCN(C(=O)[C@H1]3CC34CC4)C2 CN(C(=O)C1=C[NH1]N=C1F)[C@H1]2CCCN(C(=O)C3=NC(Cl)=CC=C3OCC(F)(F)F)C2 CCCN1N=CC=C1C(=O)NC[C@H1](CO)NC(=O)[C@H1]2CC3=CC=CC=C3S2(=O)=O CN1CCN(C)[C@@H1](C(=O)N[C@]2(C(=O)NOCC3(C)CCC3)C[C@H1](O)C2)C1 CC1=CC(Cl)=C(F)C=C1C(=O)N[C@@H1]2CCN(CC3=CC=C(C(=O)O)C(F)=C3)C2 O=C(COC1=CC=C2C(=C1)CCCC2=O)OCCSC3=CC=CC(Br)=C3 CC(C)C[C@]1(C)CN(C2=NC(N3CCC=C(Br)C3)=NC=4SC=NC2=4)CCO1 CCOC1(C(=O)NCC[C@@H1]2CCC[C@@H1](C)O2)CCSCC1 COCCOCCCNC1=CC=C(S(=O)(=O)N(CCCO)C(C)C)C(Cl)=C1 CCC1=CC=CC=C1C(=O)N2C[C@@H1](C(=O)N=C3C=C(COC)O[NH1]3)CC(F)(F)C2 CC[C@H1](C)CN(C)C(=O)C1([C@H1](C)NC(=O)CC2CCC(C)CC2)CC1 NOCCOCCCNCC1C=NC2=CC=C([N+1](=O)[O-1])C=C2[NH1]1 CCN(CCN(CC)C(=O)CNS(=O)(=O)NC)C(=O)C[C@@H1]1C(=O)ON=C1C CC(F)(F)C=1C=C(C(=O)NCC#CCNC(=O)C2=CC=NC(OC3CC3)=C2)[NH1]N=1 C[C@@H1]1CN(C(=O)[C@@H1]2C=CCS2)CC[C@@H1]1N(C)C(=O)C=3C=CN(C)C=3 C[C@@H1](CC(=O)NCCSCC(=O)N1C[C@]23CC[C@]2(COC3)C1)C(F)F COC1(C(=O)N2C[C@@H1](C(=O)NC3=CC=CC(SC)=C3)C4(CCC4)C2)CC1 CC1=CC=CC(N2CCC[C@H1](NC(=O)CN(C)CC3=CC=CC=N3)C2=O)=C1 CSCC1(CC(=O)N2[C@H1]3CC[C@H1]2[C@H1](C)[C@@H1](NC(=O)C(C)=C(C)C)C3)CC1 O=C(NCCC1(NC(=O)[C@H1](F)CC2CCCCC2)CC1)C3=CC(Cl)=CC(Cl)=C3 C=C[C@H1](C)CC(=O)NCC(C)(C)CNC(=O)C1=C[C@](C)(CC)C1 CCC[C@H1](OC)C(=O)N[C@@H1](CC)CN(C)C(=O)C[C@H1](O)C1CCCC1 CCC1CC(CNC(=O)[C@@H1](CCC(C)C)NC(=O)C2=CC=CC3=CC=NN23)C1 CC#CCCC(=O)NC[C@]12C[C@@H1]1CN(C(=O)[C@@H1](CC)NC(N)=O)C2 COC1=CC=C2C(CC(=O)N[C@@H1](CO)CNC(=O)C3=CN=CC(Cl)=C3)=COC2=C1 CO[C@H1]1C[C@H1](CNC(=O)CNC(C)=O)N(C(=O)C=CC2=CC=CC=N2)C1 C=C(CNC(=O)[C@@H1](CC(F)F)NC(=O)COCCN(C)C)C1=CC=CC=C1 CC1=C(Cl)C=CC(C(=O)N2CC=C[C@H1](NC(=O)C=3C=NN(C)C=3F)C2)=C1O CC1=CC=CC(C(=O)N[C@@H1](C)[C@H1]2CCCN(C(=O)C3=CC=C(Br)C(F)=C3)C2)=C1 CC1=CC=CC2=C1OC[C@H1]2C(=O)N3CC[C@H1]4[C@@H1](C3)CN4C(=O)C(N)=O CN(C)[C@H1]1C[C@@H1](C(=O)N2CCC([C@@H1]3CCCN(C(=O)CCCC#N)CC3)CC2)C1 COC[C@]1(C(=O)N[C@H1]2CCC[C@H1]2CN(C)C(=O)[C@@H1](C)SC)CCCCO1 CN(C)CCC1(C(=O)N2CC[C@@H1]([C@H1]3CCN(C(=O)C4(CO)COC4)C3)C2)CC1 C[C@H1](NC(=O)N[C@H1]C1[C@@H1]2CCC[C@H1]1N(C(=O)C=3C=N[NH1]C=3)C2)C4=CC=CC=C4 CC(C)=CC(=O)N[C@H1]1COC[C@H1]1NC(=O)C2=C(Cl)CC2 CCC1=C(C(=O)NC[C@H1](CC)NC(=O)COCC=2N=C[NH1]N=2)C=NN1C N=C1N=C(CC(=O)N2CCCC23CCN(C(=O)CC4(CO)CCC4)CC3)[NH1][NH1]1 CC[C@H1](CSC)NC1=CC(=N[C@@H1](C)C2CC(F)(F)C2)[NH1]C(C(C)C)=N1 O=S(=O)(CC[C@H1]1COCCO1)NCC2=NC(C3CC3)=NO2 CCSC1=CC=CN=C1C(=O)NCCC2=CCN(C(=O)C(=O)C3CCCC3)CC2 O=C(C=1C=NSC=1)N2C[C@@H1](O)C[C@H1](NC(=O)C3(C4=CC=C(O)C=C4)CC3)C2 C[C@H1](CCN(C)C(=O)[C@H1]1CCCS(=O)(=O)N1)NC(=O)C2=NOC(C)(C)C2 CN1CC[C@@H1](NC(=O)CCC(C)(C)NC(=O)C2=CC=CN=C2O)C(C)(C)C1 COC1=CC(O)=NC=C1C(=O)N2CC[C@H1]3CN(C(=O)[C@@H1]4C[C@H1]4Br)C[C@H1]32 N=CC=C1C=C(C(=O)N2C[C@@H1]3CCC[C@H1](CNC(=O)CS(N)(=O)=O)[C@H1]3C2)C=C1 CCC(CC)CCC(=O)N[C@@H1]1[C@@H1]2C[C@H1]3[C@@H1](C2)CN(C(=O)CCNS(C)(=O)=O)[C@H1]31 COCC1(C(=O)N2CC3(CCCN3C)C2)CN(C(=O)[C@@H1]4CCC4(F)F)C1 C[C@H1](CC(C)(F)F)C(=O)NC[C@@]1(C2CC2)CCN(C(=O)C=3C=NOC=3C4CC4)C1 O=C(NC[C@H1](F)CNC(=O)[C@H1](O)CN1CCCC1)C2=CC(Br)=CC=N2 O=C(NCCC[C@H1]1CCCCN1C(=O)C2=CC(C(F)F)=NC=N2)C3=CC(Br)=CO3 CC[C@@]1(NC(=O)CC2CS(=O)(=O)C2)CCCN(C(=O)[C@@H1]3CN(C(C)C)CCO3)C1 CC(=O)C1=CC(C#N)=C(SCC(=O)NC2=CN=C3C=CC=CC3=C2)O1 NP(=O)N1CCC[C@H1]1C(=O)NC2C[C@@H1]3COC[C@H1](C2)C3NC(=O)C4=CC=CO4 C[C@H1](C[C@@H1](C)NC(=O)CCNC1=CC=CC=N1)NC(=O)C[C@@H1]2CC3(CC3)CO2 CSCCC[C@@H1](NC(=O)[C@@H1]1CN(C)C[C@H1](C)O1)C(=O)NC23CCC(CC2)C3(C)C CC[C@H1](O)C(=O)N1CC[C@H1](NC(=O)C2=COC(S(N)(=O)=O)=C2)[C@@H1]1C CCCC(=O)N1[C@@H1](CC(=O)N(C)C[C@@H1](O)CCC)[C@H1]2CCC[C@H1]21 O=C(OCCNC(=O)[C@@H1](CC1CCC1)NC(=O)[C@@H1]2CCNC2=O)C3CC3 C#CC[C@@](C)(NC(=O)[C@@H1](CC)C1=CC=CC=C1)C(=O)NC2=CC=CC(OCC)=C2 C=CCN1CCN(C(=O)N[C@@H1]2CC2(C)C)CC1 CCC=1C=C(C(=O)NC[C@H1]2[C@@H1]3C[C@H1]2CN3C(=O)C4=C(Cl)C(C)=NN4C)OC=1CC CC=CC=CC(=O)N1CC[C@]2(C(=O)N(C)CCCOC(C)C)CCC[C@H1]12 C=CC1(CNC=2[NH1]C(=NCC3=CC4=NC=CC=C4[NH1]3)N=C5SC=NC=25)CCC1 COC1=NN(C)C=C1C(=O)N[C@]23CCN(C(=O)CCOCC(F)(F)F)CC[C@@H1]2C3 O=C(NC[C@@H1]1CCOC1)[C@H1](C2=CC(Cl)=CC=C2Cl)N3CC[C@@H1]3C4CCCC4 CCC1(CC)CCN1C(=O)[C@@H1]2C[C@@H1](C)N2C(=O)CCCN3CCCC3 COC1=CC=NC=C1CC(=O)NCC2(NC(=O)[C@H1](O)CN3C=NC=N3)CCCC2 CCC1=C[NH1]C(C(=O)N2C[C@@H1]3C[C@H1]2[C@@H1]3NC(=O)[C@H1](C)C4=CC(F)=CC(F)=C4)=C1 CCN(CCN(CC)C(=O)[C@H1](C)C1=CC=CC=C1C)C(=O)C2=COC(C)=N2 CC1(C)[C@H1](C(=O)N2CCC(C(F)(F)F)C2)CCN1C(=O)CSC(F)F CSC[C@H1](C)N1C[C@H1]2[C@@H1](C1)[C@@H1]2C(=O)N3CC[C@@H1](C)[C@H1](CO)C3 C[C@@H1]1CN(C(=O)C[C@]2(O)CCCOC2)C[C@H1]1CNC(=O)C(C)(C)CC3=CN=N[NH1]3 CC1=CC(=NC[C@@]2CC3[C@@](NC(=O)C4=C[NH1]C5=CC=CN=C45)(CO2)C3)[NH1]C(Cl)=N1 CC1=CC(C(=O)NCC[C@@H1]2CN(C(=O)[C@H1]3CCCCN3N=O)CCCO2)=NN1C CN1C=C([N+1](=O)[O-1])C(=NC[C@H1](O)CNC(=O)C2=CC=CC=3OC(O)=NC2=3)[NH1]1 C=CCC(CC=C)N=C1[NH1]C2=C(C(=NCCC(=O)NC(C)C)[NH1]1)COC2 CC[C@H1](CN(C)C(=O)C1=C[C@@H1]2C[C@H1](C1)C[C@H1]2O)NC(=O)C3=CC(C)=C(C)N=N3 COCC1(C(=O)N2C[C@@H1](NC(=O)C3=CN=C(Cl)[NH1]3)[C@H1](CC(C)(C)C)C2)CCC1 CN(C(=O)C=1SC=CC=1Cl)[C@@H1]2CCN(C(=O)C(C)(C)C3=CC=CS3)C2 C#CC1(C(=O)N2C[C@@H1]3C[C@H1]2CN3C(=O)C4=CC=C(C5CC5)S4)CCOCC1 CC(C)=CCCC(=O)N1C[C@H1](CNC(=O)C2=CN=C3C(=C2)NCC3)CC14CCC4 C[C@@](O)(CNC(=O)CNC(=O)C1=NC=C(N)C=C1Cl)C2=CC=CC=C2 COCC1(C(=O)N2C[C@@H1](C)CN(C(=O)[C@@H1]3CCCO3)[C@H1](C)C2)CCC1 CN(C)CCCCCC(=O)N[C@@]12CCC[C@@H1]1CN(C(=O)C3=CC=NC(S)=C3)C2 C=C(C)[C@@H1](CC(=O)NC1CC(CCNC(=O)C2=CC=CC=3SC=CC2=3)C1)OCC CC=1ON=CC=1C(=O)NCC(=O)N2CC[C@](O)(CCNC(=O)[C@@H1](F)C(C)(C)O)C2 CC[C@H1](SC)C(=O)NC[C@@](C)(O)CNC(=O)C=1C=NC2=CC(C)=NN2C=1C CC=1OC=CC=1C(=O)N2C[C@H1](CNC(=O)C3=NOC4=NC=CC=C34)[C@@H1](C)C2 CC=1ON=C(Br)C=1C(=O)NC[C@@H1](CC(F)(F)F)NC(=O)C=2C=CON=2 O=CNC1=CC(C(F)(F)F)=CC=C1S(=O)(=O)N[C@@H1](C(=O)O)C2=CC=CC=C2F COC1(C(=O)N2[C@H1]3CC[C@H1]2CN(C(=O)C4=CC=NC(N5C=CC=C5)=C4)C3)CC1 O=C(NCCCC1=CC(O)=N[NH1]1)N2CCN3C=CC=C3C24CCCCC4 CC(C)(C)OC(=O)N1CCC(N(C)C(=O)N[C@H1]2C[C@H1]3C=C[C@H1]2CC3)CC1 O=C(NCC1=NC(CNC(=O)C2C=CC=CC=C2)=CS1)C3=NC=C[NH1]C3=O C[C@@H1]1C[C@@H1](NC2=NC=NC=3C=CSC2=3)CCN1C CNS(=O)(=O)CC(=O)N1CC=CC[C@@H1]1C(=O)N[C@@H1](C)CCO C[C@H1]1CCN(C(=O)CN2CCSCC2)C[C@H1]1NC(=O)C3=CN=C(C(N)=O)C=N3 CC[C@@H1](CNC(=O)CCCC#N)NC(=O)C1=C[NH1]C(C)=C(Br)C1=O C=C(C)CN1N=NN=C1[C@H1](NCCOC2CCC2)C3=CC=C(I)C=C3F CC[C@H1](C)C(=O)C(=O)N[C@@H1](C)/C=C/C(=O)N[C@H1](C)COC C=CC(C)(C)CC(=O)N1CCC(C)(C)[C@H1](C(=O)N(C)CC2=CN=CN=C2)C1 CCN(C[C@@H1]1CCOC1)C(=O)[C@H1](COC)NC(=O)C2=CC=CC(C)=N2 CCCN1CCCC[C@@H1]1CNC(=O)C(=O)N[C@H1]2CC[C@H1]2CC(=O)OC CN(CC(=O)NC(C)(C)CNC(=O)[C@H1](O)C(C)(C)C)C(=O)OC(C)(C)C CCN(CCCNC(=O)[C@H1](O)CN(C)C)C(=O)CC(F)(F)C(C)C CC1=CSC(CCC(=O)NC[C@](C)(CC(C)C)NC(=O)CN2CCCS2(=O)=O)=N1 O=C(NC[C@@H1]1C[C@@H1]2COC[C@H1]2N1C(=O)C3=NSC4=CC=CC=C34)[C@@H1]5CC=CCC5 C[C@@H1](CC(N)=O)C(=O)N[C@@H1]1CC[C@H1]1CNC(=O)C=2C=NN3C=2NCCC3 CC[C@H1](C)CONC(=O)[C@]1(C)C[C@H1](O)CN1C(=O)CC2=CC=C[NH1]2 CO[C@H1]1CCC[C@@H1]1C(=O)NCC2CC(COC)(NC(=O)CCCC3CCCC3)C2 CC[C@@H1](CN(CC)C(=O)C[C@@H1](C)C(C)C)NC(=O)C1=CC=C(OC(C)C)C=C1Cl CON1C=NC(C)=C1C(=O)NC[C@@H1](C)C(=O)N2CCSC[C@@H1](C)C2 CCS(=O)(=O)N1CCC[C@@H1]1C(=O)N2C[C@@H1](OC)C[C@@H1](NC(=O)C3=CN=C(O)S3)C2 CC1=CN=CN=C1C(=O)NCC2=CC=C(C(=O)N(C)[C@H1]3CCC3(C)C)C=C2 CN(C(=O)[C@H1]1CCCCC1(C)C)[C@@H1]2CCN(C(=O)C3=C(N)C=CC=C3F)C2 CC(C)(CNC(=O)CCC1=CC=C(Cl)N=C1)[C@H1]2CCCCN2C(=O)CNC=O C#CC1=CC=C(C(=O)N2CC3(CC(NC(=O)CC4=NN=C(O)S4)C3)C2)C=N1 C#CC1=CC=C(C(=O)NCC(C)(C)CNC(=O)CCCCC(C)=O)N=C1 NC1=CN=CC=C1C(=O)NCCNC(=O)CCC2=CC=C([N+1](=O)[O-1])C=C2 CSC1=CN=C([C@H1](C(=O)NCCC2CC2)N(C)CC3=CC=C(F)C=C3C)S1 CC1=NC=C2C=CC(C(=O)N[C@H1](C)[C@H1](C)NC(=O)C3=CSC(C(C)(C)C)=N3)=CN12 CC(C)C1=NC(CCN=C2[NH1]C=CC(=NCC3=CN=C[NH1]3)[NH1]2)=NO1 O=C(N[C@@H1]1CCN(C(=O)C2=NC=NC=C2F)C[C@@H1]1CO)C3CSC3 C[C@@H1](CCCCNC(=O)C(C)(C)O)NC(=O)[C@H1]1[C@@H1](C2=N[NH1]C(=N)[NH1]2)C1(C)C CCN(CC1CCN(C(=O)CN(C)C(=O)C(C)C)CC1)C(=O)C[C@H1]2CC[C@H1](O)C2 C#C[C@H1](CNC(=O)CC1(N(C)C(=O)CCNC(=O)COC)CC1)C(C)C CC[C@@H1](NC(C)=O)C(=O)N(C)[C@@H1]1CN(C(=O)C2=NNC(=O)CC2)CC13CC3 C[C@@H1]1C[C@@H1](NC(=O)C=2N=CSC=2C3CC3)CCN1C(=O)C4=CN(C5CC5)N=N4 CC=1N=N[NH1]C=1C(=O)N2CC=3OC=C(C(=O)N4[C@H1]5CC[C@H1]4COC5)C=3C2 C[C@@H1]1CN(C(=O)C2=CC=CC(=O)N2O)CC[C@H1]1NC(=O)[C@@H1]3CC34CCC4 COCC(C)(C)C(=O)NCCCCCCNC(=O)CC[C@H1]1C[C@H1](C)CC(C)(C)C1 C=C[C@H1](O)C(=O)NCC1=CN(C[C@H1](OC)C2CCCC2)N=N1 C[C@]1(F)C[C@H1](C(=O)NC[C@@H1](NC(=O)C[C@@H1]2CCCNC2=O)C3CCCC3)C1 C#CCCN(C)CC(=O)N1CC[C@](O)(CNC(=O)CSC2=NN=NN2C3CC3)C1 COCC1=NOC=C1C(=O)N2CCC[C@@H1]2C(C)(C)CNC(=O)[C@@H1]3CC[C@H1]4C[C@@H1]4C3 C=C[C@@H1]1OCC[C@H1]1C(=O)N2C[C@H1](NC(=O)C=CC3=NC(C)=C(C)[NH1]3)C4(CC4)C2 N=C1N=CC(C(=O)N[C@@H1]2CCN(C(=O)C3=CC(C4CCC4)=NO3)C[C@H1]2F)=C[NH1]1 C#CCCOCC(=O)NCCC[C@@H1](CCC)NC(=O)[C@@H1]1CCC2=CN=CN2C1 CCCN(CCNC(=O)C[C@H1]1CC2=CC=CC=C2O1)C(=O)[C@H1]3CCCC(=O)O3 CCCCC(=O)N1C[C@H1]2CC[C@H1]1[C@H1](CNC(=O)[C@@H1]3CCCO[C@H1]3C)C2 O=C(N[C@@H1]1CCN(C(=O)CN2CCC2)CC[C@H1]1COCCOC)C3C4(CC4)C3 CCN1CC[C@@H1]1C(=O)N2C[C@H1]3CC[C@H1]2[C@@H1](NC(=O)[C@H1](C)SC[C@H1]4CCCO4)C3 O=C(NC1(CNC(=O)C(F)(F)C[C@@H1]2CCCO2)CCCC1)C3=CC=C(Cl)C=C3Cl C[C@@]1(C(=O)NC2=CC(Cl)=CC=N2)CCN(CC3=CC=C(OC(F)(F)F)C(Cl)=C3)C1 CC=C[C@H1](O)C(=O)NC(C)(C)CN(C)C(=O)C1=C[NH1]C2=CC=C(Cl)C=C2C1=O CCC=1C=NN(CC(=O)N2C[C@H1]3COC[C@@]3(C(=O)N(C)C(C)C)C2)C=1 CCS[C@@H1]C(=O)NC[C@H1]1CCC[C@@H1](NC(=O)[C@@H1](C)OCC(C)C)C1 O=C(CCC[C@H1]1CCCO1)N2CC[C@H1](C(=O)NCC3=NN=CN3C4CC4)O2 CCC[C@H1](NC(=O)C(C)(C)N=[N+1]=[N-1])[C@@H1](O)C(=O)NCC=1OC=CC=1C CCCC[C@@H1](O)CC(=O)NC[C@@H1]CN(C(=O)CCS(=O)(=O)NC)[C@H1]1CCCO1 CCCC[C@H1](CC)C(=O)N[C@H1]1C[C@H1](OC)CN(C(=O)CCC(=O)N(CC)CC)C1 CC1(C)[C@@H1](NC(=O)CCC(C)(C)NC(=O)C2=CC=C[N+1]([O-1])=C2)CC1(F)F CCCN(CCNC(=O)[C@@H1]1CCCC2=NN=CN21)CC(=O)NCCC#N CC(C)(C(=O)N1CC[C@@H1](N(CCO)C(=O)CN2C=CN=N2)C1)C3=CC=NS3 CC1(C)[C@@H1](CC(=O)NC2=CC=C(CCF)C=C2)C[C@H1]1NC(=O)C3=CN=CN=C3 COC1=NC=NC=C1N=C2[NH1]C(=NC3C[C@@H1]4C[C@H1]4C3)C5=CC=C(C(F)(F)F)C=C5[NH1]2 COC[C@]1(C(=O)N(C)CCCOCCNC(=O)C2(C)CCN(C)CC2)CC1(F)F CC1=COC(C)=C1C(=O)N2C[C@H1](NC(=O)[C@@H1]3CC[C@@H1](O)CN3C)[C@@H1]4CCC[C@@H1]42 CC1=CC(N)=CC(C(=O)N2CC[C@H1]([C@@H1](C)NC(=O)C(F)(F)CC(C)C)C2)=C1 COC1=CC=CC(OC)=C1C(=O)N[C@H1](CNC(=O)C2=COCCC2)C(C)(C)C CCC1(NC(=O)[C@H1](CN=[N+1]=[N-1])NC(=O)CSCCC(C)C)CCOCC1 O=C(N[C@@H1]1C[C@H1]2C[C@@H1](C1)N(C(=O)C3=CC=C4C=CC=NC4=C3O)C2)[C@@H1](O)C(F)F CC[C@@H1](SC)C(=O)N1CCC2(CCN(C(=O)CS[C@@H1]3CCS(=O)(=O)C3)CC2)C1 CCC(CC)[C@H1](C)C(=O)N[C@]12CCCN(C(=O)C3=CC=C(SC)O3)C[C@@H1]1C2 C#CCOCCN(C)C(=O)C=1C=NN(CCNC(=O)C2=CC=NC=C2)C=1 CC(C)C=1C=COC=1C(=O)N(C)CCN(C)C(=O)C2=CC=C3C(=C2)CCO3 COCC1=NOC=C1C(=O)NCC2(CNC(=O)[C@@H1]3CCS(=O)(=O)N3C)CCCC2 CNC(=O)N1CCC[C@@H1]1C(=O)N[C@@H1](C)[C@@H1](C)NC(=O)C2=CN(C3CC3)C=N2 CN1C=NC2=C(C(=O)NC[C@@H1]3CN(C(=O)C4CCCC4)[C@H1]5C[C@H1]53)N=CN=C21 O=C(C1=CN2C=CSC2=N1)N3CC[C@@H1](N4CCN(C(=O)C5(CO)CC5)CC4)C3 CC(C)S[C@@H1](C)C(=O)N1CCC(C2CN(C(=O)[C@]3(C)CCN(C)C3)C2)CC1 CCN(C)CC(=O)N1CC[C@H1](CCNC(=O)CC2=CSC3=NCCN23)C[C@@H1]1C COC[C@@H1](C)C(=O)N[C@@H1](C)CCC(=O)N=C1C=C(C)N(CCO)[NH1]1 CN(C(=O)[C@H1]1C[C@H1](O)C1)C2CCN(C(=O)C3=CC(Cl)=C4C(=C3)OCCCO4)CC2 CCCN(C(=O)CN1CC[C@@](C)(O)C1)[C@H1]2CCN(C(=O)C3=CC=NN(C)C3=O)C2 CC=1SC=CC=1C(=O)N[C@@H1]2CN(C(=O)[C@H1]3CCC[C@H1](C)C3)CC[C@H1]2C CCC=CC(=O)N[C@@]12CCN(C(=O)CC3=CC=C(OC)C(OC)=C3)C[C@@H1]1C2 CC1=CC(CN[C@@](C)(CC2CCCCC2)C3=NN=NN3C4CCC4)=NN1C CCC1=CC=C(O)C=C1C(=O)N[C@H1](C)[C@H1]2CCN(C(=O)C(C)(C)[C@H1](O)C(C)C)C2 CCN1CCO[C@H1](C(=O)N2CC=C[C@]2(C)C(=O)N[C@H1]3C[C@H1](O)[C@H1](O)C3)C1 O=C(N[C@H1]1CCCC12CN(C(=O)C3=CC=NS3)C2)C4=CC=NC5=C4CCC5 CC[C@@H1](C(=O)NCCC1(O)CN(C(=O)C=2C=C(CCOC)ON=2)C1)N(CC)CC CC1=NSC(C)=C1C(=O)N2CC[C@](O)([C@H1](C)NC(=O)CC3=C[NH1]C=CC3=O)C2 C[C@H1](OC1=CC=CC=C1C#N)C(=O)NC2CN(C(=O)C3=CCCC3(C)C)C2 CC(C)(C)CC(=O)NC[C@]1(C)CCCN1C(=O)[C@]2(F)CCOC2 CC(C)=C(Br)C(=O)N[C@@H1]1CCC[C@@H1](NC(=O)CCC2=CC(C)=NO2)C1 CO[C@@H1](C(=O)N1CC(F)(CNC(=O)C2=NOC3=CC(F)=CC=C23)C1)[C@@H1]4CCOC4 COCCN1N=NN=C1[C@@](C)(CSC)NCC2=CC(C)=NC=N2 CC(C)N(CCNC(=O)C(C)(C)[C@H1]1CCCN(C)C1)C(=O)[C@H1](O)CC[S+1](C)C CC[C@H1]1CN(C2=NN=C(C3=C[NH1]N=C3C4=CC=CN=C4)N2CCC5CC5)CCS1 C=CC(C)(C)C(=O)NC[C@H1]1CC[C@H1](C)CN1C(=O)C=2C=NN3C=CC(C)=NC=23 CC1=CC(C(=O)N2CC[C@@H1](CNC(=O)CC=3N=C(C)SC=3C)C2)=CC(=O)N1C O=C(O)[C@@H1]1CCN(C(=O)[C@@H1](O)C2CCCCCCC2)C13CCSCC3 COCCC1=NN=C(N(C)C[C@@H1]2CCCN2C(=O)[C@@H1]3CCC[C@H1]4[C@H1]3C4(F)F)S1 CC1=NC([C@@H1](CO)NC(=O)[C@H1](C)NC(=O)C=CC(F)(F)F)=N[NH1]1 CC1(C)CC(=O)NCCN1[C@@H1](C(=O)NC2CC2)C3=CC(C4CC4)=NN3C C#CCCCC(=O)N[C@H1]1C[C@@H1]2CN(C(=O)CC[C@@H1]3CCCN(C)C3)CCN2C1=O NC(=O)C1(C(=O)N2CC[C@H1](NC(=O)C3=C(F)C=CC(F)=C3O)[C@H1](F)C2)CC1 C[C@@H1]1C[C@@H1](C(=O)N[C@H1]2CCCCN(C(=O)C34COCC(C3)C4)CC2)CO1 C[C@@H1](SC1=CC=C(F)C(F)=C1)C(=O)NCCNC(=O)C2=CC=CC=C2 CN1N=NN=C1[C@@H1](NCC2=CC=CC(C(F)(F)F)=N2)C3=CN(C)N=C3Br C#CC1=CC=C(C(=O)NC[C@H1]2C[C@H1](OC)CN2C(=O)C(N)=O)C=N1 CCN(CCCNC(=O)COCC1=NC(C2CC2)=NO1)C(=O)[C@@H1]3CCCO3 CCOCC1C2(CCN(C3=NC=C(S(=O)(=O)N(C)[C@H1](C)C4CCCC4)C=C3Cl)C2)C1 COCCC[C@H1](C)C(=O)NC[C@H1]1CC[C@H1](NC(=O)C2=CC(OC)=NS2)C1 C[C@@H1](CN1CCOCC1)N(C)C2=NC3=C(C(N(C)CC(Cl)Cl)=N2)SCC3 CSC1=CSC=C1C(=O)N2C[C@@H1]3C[C@@H1](NC(=O)[C@@H1](O)CC4=CN=C[NH1]4)[C@H1]2C3 CC(C)OC1=NC=C(C(=O)N[C@H1](CC2CC2)C(=O)O)C=C1Cl CCN1N=CC(Cl)=C1C(=O)N[C@H1](CO)[C@H1](C)NC(=O)[C@H1](O)CC(F)(F)F CC(=O)N[C@]1(C)CCN(C(=O)[C@H1]2CC[C@@](F)(CNC(=O)OC(C)(C)C)C2)C1 CC(C)(C)OC(=O)N1CCC(NC(=O)NCCC2=CC=C3C=CC=CC3=C2)CC1 COC1=CC=C(C2=NO[C@H1](CNCCC[C@H1]3NC(=O)NC3=O)C2)C=C1F CCC1=CC(C(=O)N2CC(O)(CN(C)C(=O)C[C@H1](C)C3=CC=CC=C3)C2)=NN1C C=C[C@H1](C)CC(=O)N1CC2(NC(=O)[C@H1]3CC34CCC(F)(F)CC4)CC1C2 CCCCC[C@H1](O)C(=O)N[C@@]1(CNC(=O)C2CC(C)(F)C2)CCC[C@@]1(F)C CCCCOCC(=O)N1CCC(NC(=O)C2=CC3=C(Cl)C=CC=C3[NH1]2)CC1 O=C1C[C@H1](CNC(=O)[C@@H1]2C[C@@H1]3C[C@@H1]3N2C(=O)C4(CC5CC5)CCC4)CN1 COCC1=NC(C(=O)N(C)[C@H1](C)CN(C)C(=O)CN2CCC(C)CC2)=CO1 COC1(C#N)CC(C(=O)N(C)CC(=O)N[C@@H1](CO)CC2CCC2)C1 CSC1=CC(Br)=CC=C1CNC2=CC=CC(C3=COC(C)=N3)=C2 CC1=CC(C(=O)NCCN(C)C(=O)CCC(N)=O)=C(Br)S1 CC[C@H1](OC(=O)C1=CC=CC(OC[C@H1]2CCCO2)=C1)C(=O)C(C)=O CSCCN1N=NN=C1[C@H1](N[C@@H1](C=2C=NN(C)C=2)C(C)C)C3=CC=C(Cl)N3C C[C@H1]1CN(C(=O)C23CSC(C2)C3)C[C@@H1]1NC(=O)CC4=NC([N+1](=O)[O-1])=N[NH1]4 CC#CCCCC(=O)NC[C@@H1](C)N(C)C(=O)C1=CC=C(I)C(C)=C1 COC1=CC(Cl)=CC=C1C(=O)N(C)C[C@H1](O)CNC(=O)C=CBr C=CCCC1(C(=O)N2C[C@@H1](NC(=O)C3=CC4=C(C=C3Cl)NC(=O)C4)[C@H1](C)C2)CC1 CC1=CC=NN=C1C(=O)N[C@@H1]2CCC[C@H1]2NC(=O)C3=CC4=NC(F)=CC=C4O3 CCC=CC=C(C(=O)N1C[C@H1](CC(=O)N2CC[C@H1](NC(=O)OC)C2=O)C3(CC3)C1)C=C C[C@@H1](CCNC(=O)[C@@H1](C)C1CCN(C(=O)C(C)(C)CC(F)F)CC1)C(C)(C)C CN(CC(F)F)[C@@H1](C(=O)NC[C@H1]1CCCO1)C2=CC=C(F)C(C(F)(F)F)=C2 CCC1=NO[C@@H1](C(=O)NC[C@H1]C2[C@@H1](C(C)(C)C)CN(C(=O)C=3[NH1]C=NC=3C)C2)C1 CC1(C)CC=CCN(C(=O)CC[C@@H1]2CCCCN(C(=O)[C@@H1]3[C@@H1]4CC[C@H1](F)[C@@H1]43)C2)C1 CC1=CC=C(N(C(=O)C2=C(Cl)C=CN=C2Cl)[C@@H1]3CCNCC34CC4)C(F)=C1 CN1C=C(CC(=O)N2CC[C@H1](C3=CN(C4=CC=C(F)C(CO)=C4)N=N3)C2)N=N1 CC1=CN=C2N1CCC[C@H1]2C(=O)NC[C@H1]3C[C@@H1](NC(=O)[C@@](C)(O)C(F)(F)F)C3 C=C(CN1C=C(CN(C)CCCNC(=O)C2=CC3=C([NH1]2)CCCC3)N=N1)CCC COC1=CC=CC=C1CCC(=O)N[C@H1]2C[C@H1]3C[C@@H1]2CN(C(=O)[C@]4(C)CCOC4)C3 COCC[C@@]1(NC(=O)[C@H1]2CCC(C)(C)OC2)CCN(C(=O)C3=CC=CC=[N+1]3[O-1])C1 C[C@@]1(C(=O)N2C[C@H1]3C=C[C@H1]2[C@H1](O)C3)CC14CCN(C(=O)[C@@H1]5CC=CCC5)CC4 O=CC1[C@@H1](C(=O)N[C@H1]2CCC[C@]23CCN(C(=O)CSC4=N[NH1]C(O)=N4)C3)NC(=O)N1 C[C@@H1]1CN(C(=O)C2=CC=C(Cl)C=N2)C[C@@]3(CCN(C(=O)C4=NNC(=O)CC4)C3)O1 C[C@@H1](NC(N)=O)C(=O)NC[C@@H1]1CN(C(=O)C2=CC=NN=C2Cl)CCC1(C)C O=C(CC1=C[NH1]C2=CC=CC(Br)=C12)N[C@@H1]3C[C@H1]3CNC(=O)[C@@H1]4[C@H1]5CCC[C@H1]54 CC(=NO)[C@@H1]1C[C@H1](C(=O)N[C@]2(C)CCCN(C(=O)[C@H1]3CCCC(=O)N3)C2)C1(C)C N#CCCC1=CN(CCCC(=O)N(CC(=O)O)CC2=CC=C(Br)C=C2)N=N1 CCC(=O)NCC12CN(C(=O)C3(CSC)CC(F)(F)C3)CC(F)(C1)C2 CCC1=CN=CC(C(=O)NCC2(CNC(=O)C[C@H1](C)CCC=C(C)C)CCC2)=C1 COC1=CC=C(C2=NC(C)=C(CN(C)CC3(C)COC3)S2)C=C1 CCCC[C@H1](O)C(=O)N1CC[C@@]2(CCCN(CC3=CC=C(OC)C=C3F)C2)C1 COC1=CC=C(NC(=O)N2CCN(C(=O)C34CC(C3)C4)[C@H1]5C[C@H1]52)C=C1 CC(C)[C@@H1](CNC(=O)CC[C@H1]1CCCOC1)NC(=O)CN2N=C(O)C=CC2=O CSCC1(NC(=O)CC[C@@H1]2CCCCN(C(=O)C3=CC(Cl)=NS3)C2)CC1 C=C=CCCC(=O)NCC[C@H1]1CCCN1C(=O)C2=CC(O)=CC(O)=N2 CC(C)(C(=O)NC[C@H1]1CN(C(=O)[C@@H1]2[C@H1]3COC[C@H1]32)CCO1)C4=CC=NS4 CC[C@H1](CNC(=O)[C@@H1](C)CC(N)=O)NC(=O)C1=C[NH1]C2=CC(F)=C(F)C=C2C1=O O=C(N[C@@H1]1CCC[C@@H1](NC(=O)C2=CC=C3C=C(O)C=CC3=N2)C1)C4=CCCC4 CC(C)C(=O)N[C@H1]1CCCN(C(=O)C2=C[NH1]C3=CC=C([N+1](=O)[O-1])C=C23)[C@@H1]1C CCCCCCC(=O)N[C@@H1](C(=O)NC[C@H1](O)C1=CC=CO1)C2CC2 C[C@H1](CC1=NN=CN1C)NC(=O)[C@@H1](CNC(=O)C2=CN=CN=C2)N(C)C CC(C)CC[C@H1](O)C(=O)N1CCC(C[C@H1](C)NC(=O)CC=2C=COC=2C)CC1 C#CC12CC(CN1[C@H1](C(=O)NC(C)(C)CC)C3=CSC(C4CC4)=N3)C2 CC(C)S[C@H1](C)C(=O)N1CCCN(C(=O)C=2C=NN3C(N)=CC=NC=23)CC1 C=C[C@@H1]1CCN1C(=O)[C@@H1]2C[C@H1](NC(=O)C[C@@H1]3CCCCN3C)C2(C)C CCCN1C=CC(CNCC=2C=CSC=2C(=O)OCCOC)=N1 CCN(C)CC=CC(=O)NCC[C@@H1]1CN(C(=O)C2(S(C)(=O)=O)CC2)CCO1 CC1=NC(C(=O)NCC2CC(NC(=O)C[C@H1]3CCC(=O)NC3)C2)=N[NH1]1 O=C1OC[C@H1](C(=O)NCC2CN(C(=O)C3=CC=CC(=O)N3O)C2)O1 CCC1=CC=CC=2[NH1]C(C(=O)NC[C@@H1]3C[C@@H1](O)CN3C(=O)[C@H1](F)C(C)(C)O)=CC1=2 O=C(CSC1=CC=CC=C1)N2CC3(C2)CN(C(=O)C4(N5CCNC5=O)CC4)C3 O=C(CCN1C=CC=CC1=O)N2CC=C[C@@H1]2CNC(=O)C(F)(F)C3=NC=CC=N3 CN(CC(C)(C)NC(=O)C1=C[NH1]C2=CC=C(F)C=C2C1=O)C(=O)[C@H1]3C[C@@]3(F)Cl CCN1C[C@H1](C(=O)NC[C@@H1]2C=CCN2C(=O)C3=NC=C(Br)C=C3F)CC1=O COC(=O)[C@](C)(O)CNC(=O)[C@H1](F)C1CC(NC(=O)C(=O)CC(C)C)C1 COC[C@](C)(CO)CNC(=O)[C@@](C)(NC(=O)[C@H1]1C[C@@H1](N(C)C)C1)C2CCC2 C[S@](=N)(=O)N1CCN(C(=O)C2=C[NH1]C3=NC=CC3=C2F)CC1 CC(C)SCC(=O)NC1[C@@H1]2CC(NC(=O)[C@@H1]3CCCC3(C)C)C[C@@H1]12 C[C@H1]1CC[C@H1](CNC(=O)[C@H1]2CNC(=O)C2)CN1C(=O)C3=CC([N+1](=O)[O-1])=CN=C3O CC[C@@](C)(F)C(=O)N1CCC(O)(CCNC(=O)C2=CSC(COC)=N2)CC1 COC[C@H1](C)NC(=O)C[C@H1]1CCCN1C(=O)C2=CN=C3C=CC(Cl)=CC3=C2 O=C(N[C@@H1]1CN(C(=O)C2=CN=CS2)C[C@@H1]1CC3=CC=CC=C3)[C@@H1]4C[C@@H1]5CC[C@@H1]5C4 C[C@H1](NC(=O)C1=CC=C2C(=C1)CCC[C@@H1]2O)C(C)(C)NC(=O)C=3C=COC=3 C#CC1=CC=C(C(=O)N[C@@H1]2C[C@H1]3CN(C4=NC=NC=5[NH1]C=NC4=5)C[C@@H1]32)C=C1 COC1=CC=CC(C(=O)NC[C@@H1](CCNC(=O)CSC2=NC=CN2C)OC)=N1 CC(C)N(CCCNC(=O)C1=CC=CC2=CC=NN12)C(=O)[C@H1](C)CCN(C)C CC1=NOC(CCN(C(=O)CCC[C@@H1](C)NC(=O)CCP(C)(C)=O)CC)=N1 C=CN1N=CC=C1C(=O)N[C@@H1](C(=O)NC[C@H1](O)CCOC)C(C)(C)C CCCN(CCCO)C(=O)[C@@H1]1CCN1C(=O)CC=2C(C)=N[NH1]C=2C CN(C)CC1=CC(C(=O)NC[C@@]2(C)COCCN(C(=O)CCCCCC#N)C2)=NO1 COC[C@@H1]1CN(C(=O)C2=CSC(C)=C2C)CCN1C(=O)C3=CC(CSC)=C(C)S3 C=CN1N=NC=C1C(=O)N(C)[C@H1]2CCN(C(=O)C3=CC=C(C(C)(C)C)[NH1]3)C2 COC1(OC)CC[C@H1](CCNC(=O)NCCC2=NN=CN2C)C1 CC[C@@H1](CN(C)C(=O)[C@H1]1CC12CCC(C(C)C)CC2)NC(=O)C=C(C)C(F)F C[C@@H1]1CCC[C@H1]1C(=O)N2CCC23CN(C(=O)C4=CC=C(C5=CC=CC=C5F)S4)C3 CCS(=O)(=O)C1=CC=C(C(=O)NCC[C@@H1](C)N(C)C(=O)C2CCOCC2)C(Cl)=C1 COCCCCNS(=O)(=O)C1=C[NH1]C=CC1=NCC[C@H1]2CCCS2(=O)=O CC=1[NH1]N=C(C(=O)N[C@@H1]2CCCC[C@@H1]2NC(=O)C=3C=NN4C=3OCCC4)C=1O CC[C@H1](C(=O)N(C)C[C@H1](C)CNC(=O)[C@H1]1CCC2(CCOCC2)O1)N3C=CN=C3 C[C@@]1(NC(=O)C2=CC=CN3C=NC=C23)CCN(C(=O)C[C@]4(C)CCOC4)C1 COC(=O)NC(C)(C)C(=O)N[C@@H1]1CC[C@H1](NC(=O)[C@@H1]2C[C@@H1]3C=C[C@H1]2CC3)C1 C#CCN(C(=O)[C@@H1](CC)C(C)C)C1CCN(C(=O)C=2N=CSC=2CC)CC1 CN(C(=O)[C@@H1]1CC2=CC=CN=C2C1)[C@@H1]3CN(C(=O)[C@H1](O)C4=CCCCC4)C[C@H1]3O O=C(NC[C@H1]1CCN(C(=O)C2=CC=NC(Cl)=C2)C1)C3=CC=NO3 O=C(N[C@@H1]1CC[C@@H1]2CN(C(=O)[C@H1]3CN4CCC3CC4)C[C@H1]2C1)C5CCC5 CC1(N2N=NN=C2[C@@](C)(NC[C@H1]3CCCS(=O)(=O)C3)[C@H1]4COCCN4C#N)CC1 CC1=CSC=C1C(=O)N2CC3(CCC[C@@H1]3NC(=O)[C@H1](C)OCC(C)C)C2 O=C([C@@H1]1CCC2=CN=CN2C1)N3[C@H1]4CCC[C@H1]3CC(NC(=O)C5(O)CCCC5)C4 O=C1C(C(=O)N[C@@H1]2CCC[C@H1]2C(=O)N=C3C=C(C4CC4)[NH1][NH1]3)=CC5=C[NH1]N=C15 COC1=CC=CC=C1[C@H1](CNC(=O)CC2(CN(C)C)CCC2)NC(=O)C=CCO COC1=CC(C(=O)NC[C@H1](CC(C)C)NC(=O)C2(CO)CCC2)=CC(F)=C1F CCC(C)(C)CC(=O)NCCCCN1C=C(C2=CN=CC(C(N)=O)=C2)N=N1 CSCC[C@H1](O)CC(=O)N[C@@H1]1CN(C(=O)C2=CC(C)=CC(O)=C2)CC(C)(C)C1 O=C(C1=CN=C(Cl)N=C1)N2CC3(CCCN3C4=NC=NC=5[NH1]C=C(I)C4=5)C2 CC(=O)SCC(=O)NC1(CO)CN(C(=O)C[C@H1]2CCCCO2)C1 CCN1C=CC=C1C(=O)NCCCC[C@@H1](C)NC(=O)C2=NC3=CN=CC=C3S2 COC(=O)C=1OC(Br)=CC=1CNC(=O)C2(OC=3C=NN(C)C=3)CC2 CCCNC(=O)[C@@H1](C)N[C@H1](C1=CC=CN=C1OC)C2=NN=NN2C3COC3 O=C(NCC=1C=CN(C2CC2)N=1)NCC=3N=CN4C=CC=CC=34 CCCC[C@H1](O)CC(=O)N[C@@](C)(C(=O)NC1CCC=CCC1)C2CCC2 CN1CCOC[C@@H1]1CC(=O)N[C@H1](CNC(=O)CN2CSCCSC2)C(C)(C)C CC1=CC(C(=O)NC2CCN(CCNC(=O)[C@H1](C)S(N)(=O)=O)CC2)=CN(C)C1=O CCS(=O)(=O)[C@@H1](C)C(=O)NC1=NC=C(CCN(C)C)S1 O=C(N[C@@H1]1CCN(C(=O)C2CC2)CC[C@@H1]1CO)C3=C(F)C=C(O)C=C3F C[C@@H1]1C[C@H1](C(=O)N2CCN3C=CN=C3C2)N1C(=O)CC4CCN(C)CC4 COCC=1C=CSC=1C(=O)N[C@@]23C[C@@H1]2CN(C(=O)C[C@@H1]4CCC5=CC=CC=C54)C3 CCC1(CC(=O)N[C@@H1](C)CCC(=O)N[C@@H1]2CCN(CCF)C2)CCC1 CCOC(=O)C=1SN=NC=1COC(=O)C2=CN=C(C)S2 CCN(C(=O)[C@H1]1C[C@@](F)(CO)C1)[C@@H1](C)CNC(=O)C[C@@H1]2CCCS2(=O)=O COC(=O)C[C@H1](C)CC(=O)N[C@H1]1CCC[C@H1]1NC(=O)CNS(=O)(=O)N(C)C CC1(C)CC[C@H1](C[C@H1](C(=O)NCCC#N)N(CCCO)C2CCSCC2)O1 CC1=CN=C(C(=O)N2CCC[C@@H1](CNC(=O)C3=CC=C(F)C(F)=C3O)C2)C=N1 C[C@@H1](NC(=O)[C@@H1]1CC(=O)[C@@H1]1C(C)(C)C)C2CCN(C(=O)[C@H1]3C=CCCC3)CC2 O=CNCC(=O)N[C@]1(CO)CCN(C(=O)CSC2=CC=C([N+1](=O)[O-1])C=C2)C1 CC[C@H1](OC1CCCC1)C(=O)N2CCOC[C@H1]2CCNC(=O)C(C)(C)C3CCC3 CC=1C=CN2C=NC(C(=O)N[C@H1](C)CCNC(=O)[C@@H1]3CCC(F)(F)C3)=C2C=1 CCOC(=O)C12CC(C(=O)N3CCOCC4(COC4)C3)(C1)O[C@@H1]2C5=CC=CC=C5 O=S1(=O)CCC2(CC1)OCC[C@H1]2N[C@H1](CO)CC3CCOCC3 C[C@H1]1CN(C(=O)[C@H1]2C[C@H1](O)C2)C[C@H1]1NC(=O)CSCC(=O)N=C3C=C(F)C=N[NH1]3 C[C@H1](OCC1CC1)C(=O)N2CC[C@@H1]3C[C@@]32C(=O)N[C@H1]4CN(C)CC[C@@H1]4O CC[C@@H1](NC(N)=O)C(=O)N[C@@H1]1CN(C(=O)COC2CCCCC2)C[C@H1]1C(F)(F)F COCCO[C@H1](C)C(=O)N1CCCC[C@@H1]1C(C)(C)CNC(=O)C(=O)C(C)(C)C C[C@@H1]1CC[C@H1]1C(=O)N2CC3(CCCN(C(=O)C4=CC=CC5=C4NCCC5)C3)C2 CN(CC(=O)N[C@H1]1C[C@H1](CNC(=O)C2=CN=C(C3CCC3)S2)C1)S(C)(=O)=O C=C1CCN(C(=O)[C@H1](O)CC(C)C)[C@H1](C(=O)NC2(C(=O)N(C)C)CC2)C1 CO[C@H1](C(=O)N[C@]12C[C@H1]1CN(C(=O)C3=CC=C(Br)N=C3N)C2)C4CCC4 CC1=NC(C=CC(=O)NC[C@H1]2CC[C@H1](CNC(=O)CN3C=NC=C3C)CC2)=CS1 CC=1[NH1]C(=N)N=C(O)C=1CC(=O)N2CCC[C@H1]2CN(C)C(=O)CC(=O)N(C)C C=CC[C@@H1](CNC(=O)C12COC(COC)(C1)C2)NC(=O)C3=CC(F)=N[NH1]3 C=CCC[C@H1](O)CNC(=O)C/C=C/CNC(=O)C1=NC(C)=CC=C1F C[C@H1](C(=O)N1CCN(C(=O)C2=COC(S(C)(=O)=O)=C2)C[C@H1](O)C1)C3=CC=NN3C C[C@H1](C(=O)N1CC[C@@H1](C)[C@@H1](CC(=O)NOC[C@H1](O)C(C)(C)C)C1)C(F)F CN1N=CC(S(=O)(=O)NC2=C(Br)C=CC(F)=C2F)=N1 CCOCCN1N=C(CC2=CC=CS2)N=C1CC3=C[NH1]N=C3O C[C@@H1](C(=O)NCCCOCCC(=O)NC=1C=NN(C)C=1Cl)C2(O)CCC2 CC=1C=CN(C[C@H1](C)C(=O)NC[C@@H1]2CCN(C(=O)C34CC(C)(CCO3)C4)C2)N=1 CC(C)(C)C1=CC(C(=O)NC2(CNC(=O)C3(CF)CC3)CCCC2)=CC=N1 CO[C@@H1](CCNC(=O)[C@H1]1CCCN1C=O)C(=O)N2CC(C)(CSC)C2 CN1CCC(OCC(=O)N[C@]23C[C@H1]2CN(C(=O)CN4C=NC(=N)[NH1]4)C3)CC1 C#CCN(C)C(=O)[C@H1](CCOC)NC(=O)C=1C=NN(C)N=1 CC1=CN=CN1CC(=O)N(C)[C@H1](C)CCNC(=O)C2=NC=CC=C2C(F)(F)F CC1=NC=C(C(=O)NC[C@@]2(O)CCN(C(=O)C[C@H1]3CCC4(CCC4)CO3)C2)S1 COCCN1N=NN=C1[C@@]2(NCCCN3CCCOCC3)CCCO[C@H1]2C(C)(C)C CSC1=NC=C(C(=O)NCC2(O)CC(NC(=O)C3=C(C)C=C(F)C=C3C)C2)S1 O=C(NC[C@@H1]1CCCCN1C(=O)C2=CN=N[NH1]2)[C@@H1](O)C(F)(F)F C[C@@H1](O)C[C@@H1](C)CNC(=O)CCC1(NC(=O)CSCC(F)F)CCC1 CNC(=O)C(C)(C)C(=O)N[C@@H1]1CC2=CC=CC=C2[C@H1]1NC(=O)[C@@H1]3COC(=O)O3 COC(=O)C=1C=C(CNC(=O)NC2=CC=CC(C3CC3)=C2C(F)(F)F)N(C)C=1 CCCC[C@H1](CNC(=O)C(C)(C)C1=CC=C(F)C=C1)NC(=O)CNC(C)=O O=C([C@@H1]1C[C@H1]1C2=CC=CC=C2)N3CCN(C(=O)C4=N[NH1]C5=C4CCCC5)[C@H1]6C[C@@H1]63 O=C(NC[C@H1]1CCCCN(C(=O)[C@@H1]2CC23CCC3)C1)C=4C=CN5C=NC=C5C=4 CC[C@]1(C)C[C@@H1]1C(=O)N2CCO[C@H1](CN(C)C(=O)C=3OC=NC=3C4CC4)C2 COCCC1(C(=O)N2CC[C@H1](N(C)C(=O)C3=CC(C)=C(Cl)S3)[C@@H1](C)C2)CCCC1 COC1=CC=C(Cl)C(CC(=O)NC[C@@](C)(CO)NC(=O)C[C@@H1]2C=CCC2)=C1 CCOC1(CNC(=O)C=2N=COC=2CC)CN(C(=O)C3=N[NH1]C=C3[N+1](=O)[O-1])C1 O=C(N[C@@H1]1C[C@@H1]2CC[C@H1](C1)N2C(=O)C3=C(Cl)CCCC3)C4=CSC(CO)=N4 CC1=CC=C2[NH1]C(C(=O)N3CCC[C@H1]3[C@@H1](C)NC(=O)[C@H1](O)C(F)(F)F)=C(Cl)C2=C1 C[C@@H1]1CCN(C(=O)CN2CCCCS2(=O)=O)C[C@@H1]1NC(=O)C3=CN(C)N=N3 CCC(CC)(CNC(=O)[C@@H1]1CCNC1=O)NC(=O)CC2(CO)CC2 COC1(CNC(=O)C2=CN=C3C=CC(C)=CN23)CN(C(=O)CCSCC(N)=O)C1 COCC[C@H1](C)C(=O)N[C@]12CCCN(C(=O)[C@@H1]3C=CCC3)C[C@@H1]1C2 C[C@@H1](CC(=O)N1CCCN(C(=O)C2=CC(C3CCC3)=NO2)[C@H1](C)C1)CC(C)(C)C CC(C)(C(=O)NCC=1C=COC=1C(=O)NCC=CC2CC2)C=3C=NSC=3 CC1=CC=C(O)C=C1C(=O)N2C[C@@H1](C)C[C@H1](C(=O)N(C)C3CC=CC3)C2 CCC1=CC=C(C2=NC(CN3CCN(C(=O)C4=CN=N[NH1]4)CC3)=CS2)C=C1 C=C[C@@](C)(CC)C(=O)N(C)[C@H1](CNC(=O)COC1=CC=CC=C1)C2CC2 C[C@H1]1CCN(C(=O)COC2=CC=C(Cl)N=C2)[C@H1]1CNC(=O)CC3=CN=NS3 CC=1OC(C(=O)N2C[C@H1]3CCC[C@H1]3[C@H1]2C(=O)NC(C)(C)CCN(C)C)=CC=1CO CN1C[C@H1](C(=O)NCC[C@H1]2CCCN2C(=O)C3=CC(N)=CC=C3[N+1](=O)[O-1])NC1=O C=C(C)CC(=O)N[C@H1]1CCN(C(=O)C=2C=NN(C3CCCC3)C=2C)C[C@H1]1CC C[C@H1]1CCC[C@@]1(NC(=O)COC2(C)CCCC2)C(=O)NC3(C4=NC(=O)O[NH1]4)CC3 CC(C)(CN[C@H1](C1=CSC(Cl)=N1)C2=NN=NN2C3CCCCCC3)C(F)F C#CC1=CC=CC(C(=O)N[C@@H1](CNC(=O)CCCC2=NC=CS2)C3CC3)=C1F CSC1=C(F)C=CC=C1C(=O)NCC2(NC(=O)[C@H1](O)CF)CCCC2 O=C(CC=1C=CSN=1)N[C@@H1]2CCN(C(=O)CC3=CN=C(C(F)(F)F)S3)C2 C=C[C@@H1](C)C(=O)NC1CC2(C1)CC(NC(=O)[C@H1]3CCC3(F)F)C2 O=C([C@H1]1C[C@@H1]1F)N2CC3(CCCCN3C(=O)[C@@H1]4CCCN4C5CC5)C2 O=C(NC[C@@H1]1CCCN1C(=O)C2=CC=C(C3=CC=NC=C3)O2)C4CC(F)(F)C4 CC[C@H1](F)C(=O)NC[C@@](C)(CC(C)C)NC(=O)C1=CC=CC=2N=C(C(F)F)SC1=2 C[C@@H1](CCNC(=O)C1(P(C)(C)=O)CC1)NC(=O)[C@H1](C)[C@@H1](C)S(C)(=O)=O CC1=NOC=C1CCC(=O)N[C@H1]2C[C@H1](O)[C@@H1](NC(=O)C3=CC=C(Cl)O3)C2 CCC1(C(=O)OCC2=CC3=CC=CC=C3C(Cl)=N2)CCC1 C[C@@H1](CC(=O)N1CCCN(C(=O)C2=CC=C3N=NN(C)C3=N2)CC1)CC(C)(C)C CCCN(CC(=O)N1C[C@H1](C)CC[C@H1]1CC)C(=O)CC2(OC)CCC2 CCC=1[NH1]N=C(C(=O)N2C[C@@H1]3CC[C@@H1](N(C)C(=O)CC[S@](C)=O)[C@H1]3C2)C=1Cl COC=1C=C(C(=O)N[C@@]23CC[C@@H1](C[C@H1]2NC(=O)CC4(CS(C)(=O)=O)CC4)C3)[NH1]N=1 COC1=CC=C(C(=O)N2CC[C@@]3(NC(=O)CNC=O)CCC[C@@H1]23)C=C1 C[C@H1](OC(=O)[C@@H1]1CCC(=O)N(C(=O)[C@@H1]2CCCO2)C1)C3=CC=CO3 CC(C)=CCC[C@@H1](C)NC(=O)C1(C2CC2)CN(C(=O)[C@H1]3CCCC(=O)CC3)C1 CC(C)(C(=O)N1CCN(C(=O)CCCF)C2(CCC2)C1)C3CCC3 COC1=CC(N)=C(F)C=C1C(=O)N[C@H1](CCN(C)C(=O)C2=CC=C(Cl)O2)C(C)C CCCC1(C(=O)N[C@H1]2CCN(C(=O)C[C@H1](C)O)[C@H1]2C)CC1 CC1=NC(C(=O)N[C@H1]2CCCN(CCCOC3=CC=CC=C3Cl)[C@H1]2C)=C(C)O1 CCC1=C(C(=O)N2C[C@@H1]3CC[C@H1](C2)CN3C(=O)CC(C)C)C=NN1CC C=CCO[C@@H1](C)C(=O)NCC[C@H1]1CC(F)(F)CN1C(=O)CC2=NN(C)C=C2Cl CC1=CC=CN=C1CN2CC[C@@H1](C(=O)NC3(C4=CC=CC(Br)=C4)COC3)C2 COC1(CNC(=O)[C@@H1]2CCC3=NC=CN32)CN(C(=O)C4=NO[C@@H1](C)C4)C1 O=C(NCC=1OC=CC=1C(=O)NCC2=CC(F)=CC(F)=C2)C3=NO[C@@H1]4COC[C@H1]34 C=C=C[C@@H1](C)C(=O)N1CC(C)(C)OC[C@@H1]1CNC(=O)C=2C=C[NH1]C(=N)C=2[N+1](=O)[O-1] CC1=CC=C2N=CN=C(N3CC[C@@H1](CC(=O)NC4=CC=CN=C4C#N)C3)C2=C1 CC1=CC(C#N)=CN=C1C(=O)NC[C@@H1]2CC[C@H1](C)CN2C(=O)C3=CC[C@H1](C)CC3 C=C(CC)CN1C=C([C@@H1](C)N(C)C(=O)[C@@]2(C)CCCS2(=O)=O)N=N1 CSCCNC(=O)[C@H1](NC(=O)C=1SC(F)=CC=1C)C2=CC=CC(C(F)(F)F)=C2 C[C@@H1](C(=O)NCC[C@H1]1CCCCN1C(=O)CCCC(C)(F)F)N(C)C C[C@H1](O)[C@H1](C)C(=O)NC[C@@H1](C)NC(=O)CC1=NC=NC=C1Cl C=CC1(C(=O)NC2CC(CNC(=O)CCC(=C)Br)C2)CC1 NC1=CC=C(C(=O)N[C@H1]2C[C@@](F)(CNC(=O)C3=CC(C(N)=O)=C[NH1]3)C2)C(Cl)=C1 CC=CCCC(=O)NCCOC(C)(C)CNC(=O)CC1=C(C)C=CC=C1C C[C@H1]1CN(C(=O)C2=CN=CC3=C2CCC3)CCN1C(=O)C[C@@H1]4CCCC(F)(F)C4 CCCCCC[C@@H1](F)C(=O)N1CC(NC(=O)C2=CC=CC=3SN=CC2=3)C1 CC1=CC(Cl)=CC(C)=C1C(=O)N2CC[C@H1](C)[C@@H1](NC(=O)C3=CC=C(O)N=C3Cl)C2 C=CC[C@@H1](NC(C)=O)C(=O)NCC(C)(C)CNC(=O)C(F)=C1CCCC1 CCOCCCC(=O)N1CC(NC(=O)C2=CN=C(C)C(C(F)(F)F)=C2)C1 CC(C)(CC1=CN=N[NH1]1)C(=O)N2[C@H1]3CC[C@H1]2CN(C(=O)CC4CC(C5CC5)C4)C3 N#CC1=CC=NC=C1NC(=O)[C@H1]2C[C@H1]2C(=O)N[C@]3(C#N)CCS(=O)(=O)C3 CN(C(=O)C1=CC=C(N)C(O)=C1)[C@H1]2CN(C(=O)C[C@H1]3CCC34CCC4)CC25CC5 CC1=CC(C)=C(C(=O)N[C@@H1]2C[C@H1]3[C@@H1]2CCN3C(=O)C4=CC=CC(CO)=N4)C(O)=N1 CC[C@@H1](C)C1=NC(C2=CC=C(F)C(C)=C2)=NN1C3=CC=CC(OC)=C3C CC(C(=O)N1CCO[C@@H1]([C@@H1](C)NC(=O)C2=CCCC2)C1)=C3CCC3 CC1=CN=CC(C(=O)N2CCC[C@@H1](NC(=O)C3=CC=CN=C3)CCC2)=C1 COC[C@@H1](NCC1=N[NH1]C2=CC([N+1](=O)[O-1])=CC=C12)C3=CC=CC=N3 CC[C@H1](NC(=O)C1=NOC2=C1C[C@H1](NC(=O)C[C@@H1](C)O)CC2)C3=CC=C(C)O3 COC1=CC=C(N(C)C(=O)C=2SC=CC=2CC#N)C=N1 CN(C)[C@H1]1C[C@@H1](C(=O)NC2CN(C(=O)[C@@H1]3CCC[C@H1]4C[C@H1]43)C2)C1 CC1=NC=CN=C1C(=O)N[C@@H1](C)CN2C=C(CNC(=O)CS(C)(=O)=O)N=N2 C[C@@H1]1CN(C(=O)C2=CC=C([N+1](=O)[O-1])C(N)=C2Cl)CCN1C(=O)[C@@H1]3C[C@H1]4C=C[C@@H1]3O4 CC(C)CO[C@H1](C)C1=NOC(COC(=O)[C@@H1](C)N(C(=O)OC(C)(C)C)C2CC2)=N1 C=C1CCCN(C(=O)[C@H1](CNC(=O)C2(N3C=CC=C3)CC2)N(C)C)C1 O=C([C@@H1]1C[C@H1]2C[C@@H1]2N1C(=O)C3=CC=C(O)N=N3)N4CCO[C@H1](C5=CC=CC=C5)C4 CCN(C)[C@]1(C)CCN(C(=O)CC2(N(C)C(=O)C3=CN4C(=N3)CCC4)CC2)C1 COC=CC1=C(C2(C(=O)N[C@@H1]3C[C@@H1]4C[C@H1](NC(=O)C=5C=CSC=5)[C@H1]3C4=O)CCC2)C=N1 C[C@@H1]1C[C@@H1](NC(=O)[C@@H1]2CC23CC(F)(F)C3)CCN1C(=O)C4=CC=C(C(F)F)O4 CCCC(=O)N[C@H1](CC(=O)N(C)C[C@@H1]1CCCO1)C(C)C CCSC1=CC=C(C(=O)N(C)C[C@H1]2CN(C(=O)[C@H1](CC)CCOC)CCO2)C=N1 C[C@@H1](CN(C)C(=O)CCS(C)(=O)=O)NC(=O)[C@]1(O)CCOC1(C)C CC(=O)N1[C@H1]2CC[C@@H1]1C[C@@H1](CNC(=O)C3=CC=C(NS(=O)(=O)C4CC4)C=C3)C2 C=C1CC(C(=O)NC[C@@H1]2CCN(C(=O)[C@@H1](CC3=CC=CC=C3)C4CC4)C25CC5)C1 CC(C)(F)CCC(=O)N[C@H1]1C[C@H1](F)CN(C(=O)C2(C#N)CC=CC2)C1 CCCSCCC(=O)N1CCC[C@@H1](C(=O)NC[C@H1]2CCCN(C)C2=O)CC1 C#CCC(CC#C)C(=O)N1C[C@H1](O)C[C@H1]1CNC(=O)C2(C)CC3(CC3)C2 CC1=NC(N2CCOC[C@@H1](C(=O)NCC3[C@H1](C)[C@H1]3C)C2)=NC(C)=C1Cl COCCCCC(=O)N1CCN(C(=O)C/C=C/C(C)(C)C)[C@H1](CO)C1 COC1=NC(Cl)=C(C(=O)N2CCC[C@]23CCN(C(=O)[C@@H1]4COC(C)(C)O4)C3)S1 O=C(NC[C@H1]1CCC[C@@H1]1NC(=O)[C@H1]2CCCCCC2(F)F)C3=N[NH1]C=C3C4CC4 CC1=C(C(=O)N[C@H1]2CCN(CCCO)C[C@H1]2C(N)=O)C=NN1CCN(C)C O=C(CC[C@@H1]1CCCOC1)N[C@@H1]2CN(C(=O)CC3(C4CC4)CC3)C[C@@H1]5CCC[C@H1]25 CC1=C(NC[C@@]2(C)C[C@@H1]2Br)N=CN=C1NC3CN(C4CCOCC4)C3 CCC1=CN=CC=C1[C@@H1](C)NC(=O)NCC2=CC=C(OCC(F)F)C=C2 CN(CCCC1CCOCC1)C[C@@](C)(O)C2=CC=CC(Cl)=N2 CCC(CC)C(=O)N[C@H1]1CC[C@@](C)(CNC(=O)CC2=CN=C3N2CCOC3)C1 CC=1N=CSC=1C(=O)N[C@@H1]2CC[C@](C)(CNC(=O)C34CCC(F)(CC3)CC4)C2 CC1=CC=CC(C(=O)N[C@@H1]2CCCN(C(=O)C=3C=C(Br)N(C)N=3)C2)=C1 CC=CC=CC(=O)N[C@@H1]1C[C@@H1]2C[C@H1](NC(=O)C[C@H1]3CCCCN3C)[C@H1]1C2 [N-1]=[N+1]=NC1(C(=O)N[C@H1]2C[C@](F)(CNC(=O)CC3=CSC=N3)C2)CC1 C[C@@H1]1C2=C[NH1]N=C2CC[C@@H1]1C(=O)NC[C@H1]3C[C@@H1](C)N(C(=O)CC4=CC=CC=N4)C3 CC1=C(C)C[C@@](C)(NC(=O)[C@H1](C)N(C)C(=O)C[C@H1]2COCCO2)CC1 CC=CC=CC(=O)N[C@@H1]1[C@@H1](CN=C2C=C(Cl)N=C[NH1]2)CCC13CCC3 CCOC1CC2(C1)C[C@H1]2C(=O)NCCO[C@H1]3CCN(C(=O)C=C4CC[C@H1](C)C4)C3 CC(C)(C)N1N=NN=C1[C@@]2(NC[C@@H1]3CC3(Br)Br)CCCN(C(C)(C)C)C2 C#CC1=CC=C(NC(=O)[C@H1](CN2C=NC=N2)NC(=O)CN(C)CC)C=N1 C#CCOCCOCC(=O)N1CC[C@@H1](C)[C@@H1](N(C)C(=O)CC=2OC=CC=2C)C1 CC(C(=O)N1CC2(CNC(=O)[C@@H1](C)CC(F)(F)F)CCC1CC2)=C3CC3 CC(C)CC1(C(=O)NC[C@@H1]2CC(C(=O)N3CCO[C@H1](C(C)(C)C)C3)=NO2)CC1 O=C(N[C@@H1]1CC12CCN(C(=O)CC3=CC(Br)=CS3)CC2)C4=CC=C(F)C(F)=C4Cl CC1=CC=CC=C1C2(C(=O)N[C@H1](C)CNC(=O)C=3C=CN(C)C=3)CCCC2 C#C[C@H1]1CN(C(=O)[C@H1]2CC=CCO2)CCN1C(=O)C3C(C)(C)C3(C)C CC(C(=O)N1CC[C@H1](NC(=O)C2=CC(F)=CN=C2O)[C@H1](C)C1)=C3CC3 C#CCCCC(=O)NC[C@H1]1CC(C)(C)CC[C@@H1]1NC(=O)C2=CC=C(Cl)C(OC)=C2 C[C@H1](C(=O)N1CC[C@@H1]1CNC(=O)/C=C/C2=CC=CC(F)=C2Cl)C(C)(C)C CCC1=CC=C(OC)C(C(=O)NCC2=CC=CC(N3CCOC3=O)=C2)=C1 CN1CCCC[C@@H1]1C(=O)N2CC(C(=O)NCCNC(=O)C3=CC=C(F)C(O)=C3)C2 CCC[C@H1](C)C(=O)N1CCC2=NC(O)=CC(C(=O)N[C@@H1](C)CC)=C2C1 CC[C@H1](C)C1=CC=CC(N[C@](C)(C2=NN=NN2C3COC3)C4CC(C)C4)=C1 CCN(CC(F)(F)F)C(=O)[C@@H1]1C[C@H1]1C(=O)NC2=CC(Cl)=CC=C2C(F)(F)F COC(=O)[C@@H1]1[C@@H1]2C[C@H1](F)CN2CN1C(=O)C3[C@H1]4CC(N)C[C@H1]34 COC1=CC=C(Cl)C(Cl)=C1C(=O)NC[C@H1]2CN(C(=O)[C@]3(CF)CC3(F)F)CCO2 CC[C@@H1](CC(C)C)C(=O)N1CC([C@@H1](O)C(=O)N2CC(N3C=C(C)C=N3)C2)C1 CC1=CC=C(C(=O)NC23CC(CNC(=O)C=4C=CSC=4C(F)(F)F)(C2)C3)C=C1Cl CC1=CC=NC(O)=C1C(=O)N2C[C@H1](O)[C@H1](CNC(=O)[C@H1]3C[C@@H1]3C(C)(F)F)C2 COCC[C@@H1](NC(=O)CC[C@H1]1CCCOC1)C(=O)N2C[C@H1]3CSC[C@H1]3C2 CN(C)[C@H1]1C[C@H1](C(=O)N[C@@H1]2CC[C@@H1]2NC(=O)C=3C=C(O)N(C)N=3)C1 O=C([C@H1](O)CNC(=O)C12CCC(CC1)CC2)N3CC[C@@H1](O)C(F)(F)C3 CC1=CC(C(=O)N(C)C[C@H1]2CN(C(=O)C=CI)CC23CC3)=CN=C1O CC1(C)[C@@H1](C(=O)N[C@@H1]2C[C@H1]3CC[C@@H1]2[C@@H1](NC(=O)C4=CC=CO4)C3)CCS1(=O)=O CC=CCC(=O)N1C[C@@H1](O)[C@@H1](CNC(=O)C2(C)CCC2)C1 CCC1=NC=C(CNC(=O)[C@H1](CCC(C)C)NC(=O)CN(C)C(=O)COC)[NH1]1 CSC1(C(=O)N[C@@H1]2C[C@@H1](NC(=O)OC(C)(C)C)C23CCC3)CC1 CCC1CC(C(=O)N(C)CCC(=O)N[C@@H1]2CCC[C@@H1]2C3CC3)C1 C[C@]1(C(=O)NCC2=CC=CC=C2O)CCN(C(=O)NC3=CC(Cl)=CC=C3Cl)C1 CCOC(=O)[C@@H1](C(=O)N1CCC2(CCO2)CC1)C(C)C C=CC[C@](C)(CC)C(=O)N[C@H1]1C[C@@H1](C(=O)NCC2CCCCC2)C1 C1=CC=C([C@@H1]2C3=CN=CN3CCN2CC=4C=NN5C=4CCCC5)C=C1 O=C(CC1=CC=C(Cl)C(Cl)=C1)NC[C@H1]2C[C@H1]2CNC(=O)C(C3CCC3)C4CCC4 COC(=O)[C@@H1]1CCCC[C@@H1]1C(=O)N[C@H1](CNC(=O)C2(O)CCC2)C3=CC=CC=C3 CCO[C@@H1]1CN(C(=O)C[C@H1]2CC(=O)C3=CC=CC=C32)C[C@H1]1CNC(=O)C=C(C)Cl COC1=C(C)C=CC=C1CN[C@H1]2CCN(C(=O)C3=CC4=CC=C(O)C=C4O3)C2 CCN(CCNC(=O)C[C@@H1]1CCOC2=CC=CC=C21)C(=O)[C@@H1]3CCCC(C)(C)C3 CC=C(F)C(=O)N1C[C@H1](OC)C[C@H1]1CNC(=O)C2=C3CCN=C3NC=C2 CCO[C@@H1](CC(=O)NC[C@H1]1CCC[C@H1]1NC(=O)CN2C=NC(=N)[NH1]2)C(C)C CCC1(C(=O)NC[C@H1](NC(=O)CC2(OC)CCOCC2)C3CCCCC3)CCC1 O=C(CN1C=CC(=O)C([N+1](=O)[O-1])=C1)N[C@@H1]2CN(C(=O)[C@H1]3C[C@H1](O)C3)CC4(CC4)C2 CCC1=NC(C)=NC=C1C(=O)NC2(CNC(=O)C(C)(C)C3CCOCC3)CC2 O=C(CC1CC2(CC2)C1)NC[C@@H1]3CCCCN3C(=O)C4=CC=C(F)C=C4Br CN1OC(C(=O)N[C@H1]2[C@@H1]3CN(C(=O)C4=CSC5=C(F)C=C(F)C=C45)C[C@@H1]32)=CC1=O C=CCC[C@@H1](C(=O)NCCC#N)N1CCC[C@@](CO)(OC)C1 CC(C)CC[C@@H1]1CCCN1C(=O)[C@@H1](O)CNC(=O)C2=NO[C@H1]3COC[C@@H1]23 C=CC(F)(F)C(=O)N1CCO[C@H1](C(=O)N[C@H1](CCCCC)C2CC2)CC1 CC[C@@H1](C(=O)N1C[C@@H1](NC(=O)C2=CC=CC(F)=C2Cl)C3(CC3)C1)C(F)(F)F C[C@@H1]1OCC[C@]12CN(C(=O)NC3CCN(CC(F)F)CC3)CCO2 C[C@H1]1CN(C(=O)COC=2C=N[NH1]C=2)C[C@@H1]1NC(=O)C3=NN(C)N=C3C(F)(F)F CC(C)(O)C#CC(=O)N[C@@H1]1CCCC[C@@H1]1CNC(=O)C=2C=CC3=CC=NN3C=2 C[C@@H1]1[C@@H1](NC(=O)C(C)(C)[C@H1]2CCCO2)CCN1C3=NC=NC=C3I CC1(CCNC(=O)C2=COC=N2)CCN(C(=O)[C@H1]3C=CCC3)CC1 O=C(N[C@H1]1C[C@@H1]2C[C@H1]1[C@H1](NC(=O)[C@]3(CO)CCCO3)C2)C4=CC=5C=N[NH1]C=5C=N4 CSC1=NC(N[C@@H1]2CCN(C(=O)C3=NC(C(C)C)=NC=C3F)C2)=NC=C1C CC(F)(F)C1=NC(C(=O)N2CCSC[C@H1]2CCNC(=O)C34CC(CO3)C4)=CS1 CN1CCC(CC(=O)N2CC[C@H1](O)[C@H1](N(C)C(=O)[C@@H1]3CC[C@H1](F)C3)C2)CC1 C=CC[C@]1(NC(=O)[C@H1]2CCSC2)CCCN(C(=O)C(=O)C3=CC=CC(C)=C3)C1 CC(=O)OC[C@@H1]1CCN(C(=O)C2=CCN(C(=O)[C@H1](O)C3=CN=CN3C)CC2)C1 COC1=NC(C)=CN=C1C(=O)N2CC(N(C)C(=O)[C@H1]3CCC[C@@H1]3C)C2 CC1=CC=C(C(=O)N2CC[C@@H1](NC(=O)C=3N=COC=3C4CC4)C[C@H1]2C)N=C1O COCCC1=NOC(CN2CCC[C@H1](CNC(=O)[C@H1](C)CC3=CC=CC=C3)C2)=N1 CN1CCC(C)(C(=O)N2CC[C@@H1]3[C@@H1](NC(=O)CC4=CN=CC(F)=C4)[C@@H1]32)CC1 CC1=CC(C)=C2[NH1]C(C(=O)N(C)C[C@H1](C)N=C3[NH1]C4=CC=CC(Br)=C4O3)=CC2=C1 CCC=1SC=NC=1C(=O)N(C)[C@@H1](C)CCNC(=O)C=CC2=CC=C(SC)C=C2 CC1=CC=C2C(=O)C(C(=O)N(C)CC[C@H1](C)NC(=O)C3=CN=CC=N3)=C[NH1]C2=C1 CCO[C@H1](C(=O)N(C)CCCCCCN=C1N=C(C2CCCC2)[NH1]S1)C(C)C CSC=1C=CSC=1C(=O)N[C@]2(C)CCN(C(=O)[C@H1]3CCCC[C@H1]3C(N)=O)C2 CCN1N=CN=C1C(=O)N2CCN(C(=O)C3=CCSC3)C[C@@H1]2C4CCC4 C[C@@H1](C(=O)N1C[C@@H1]2C[C@]2(CNC(=O)C3CN(S(N)(=O)=O)C3)C1)C4=CC=CC(Cl)=C4 CC[C@H1](F)C(=O)NC[C@@H1]1CN(C(=O)CC2=CC=CC=N2)C[C@H1]1C3=CN=CN3C CC[C@@H1](CNC(=O)C1=CC=NN1C)NC(=O)C2=CSC=C2SC CCC1(C)CC(C(=O)NCCCC[C@H1](C)NC(=O)C[C@H1]2OCCC=3C=CSC=32)C1 C[C@@H1](O)C1=CC=C(C(=O)N2CC[C@@H1]2CNC(=O)[C@H1]3CCC(=O)NC3)C=C1 CN1C[C@H1](C(=O)NCC2(CNC(=O)CSC3=CC=C(F)C=C3)CCC2)NC1=O O=C(CCNC(=O)NC1=NC=CC(C(F)(F)F)=N1)NC2=CC=CC=C2 CN(C)[C@@H1](CNC(=O)[C@@](C)(O)C1=CC=CC2=CC=CC=C12)C3=C(F)C=CC=C3F CC=1ON=C(Br)C=1C(=O)N2C[C@@H1](NC(=O)C(C)(C)CF)[C@H1](C)C2 CN1C=C(C(=O)N(CCCNC(=O)C2(C(F)F)CCC2)C3CC3)C(C4CC4)=N1 CN1CCC(ONC(=O)[C@@]2(C)CN(C(=O)C3=CC=CO3)C(C)(C)C2)CC1 CO[C@H1](CC1CCCCC1)C(=O)N2CCOC[C@@H1]2CNC(=O)/C=C/C(C)C C[C@@H1]1C[C@H1](C(=O)N[C@@H1]2CC[C@H1]2O)N1C(=O)C3C=CC=CC=C3 CN=C1[NH1]C=C(C(=O)N(C)C2CC(NC(=O)C=3OC(C(C)C)=NC=3C)C2)O1 CCC[C@H1](NC(=O)[C@H1](F)CCC(C)C)[C@@H1](O)C(=O)NCC[C@@H1]1CCCO1 C[C@@H1](CC=1N=C[NH1]N=1)NC(=O)[C@@H1](NC(=O)C2=CC=[N+1]([O-1])C=C2)C3CC3 CCOCC[C@@H1](NC(=O)C1=CC2=CC=NC=C2[NH1]1)C(=O)N(C)OCC CC(C)CN1CCC[C@H1](C(=O)N2CC3(CN(C(=O)CSC(C)(C)C)C3)C2)C1 CCCSCC(=O)N(C)C[C@@H1]1COCCN1C(=O)COC[C@H1]2CCOC2 CCCOC1=CC=CC=C1C(=O)NC[C@H1]2[C@@H1]3CN(C(=O)[C@H1]4CCCCN4C)C[C@H1]23 CC(C)CCSCC(=O)N[C@@H1]1CN(C(=O)C2=NOC3=C2CCCC3)C[C@@H1]1C4CC4 CC(C)C(=O)NC[C@H1]1CN(C(=O)[C@H1]2CCC3(CCC3)C2)CC4=CC=CC=C41 CC(C)N1CC(C(=O)N2C[C@H1](CN(C)C(=O)C3(S(N)(=O)=O)CC3)C4(CC4)C2)C1 CC1=NSC=C1CNC(=O)CCCN2C=C(C3=CC=NC(F)=C3)N=N2 CC1(C)C[C@@H1](C(=O)N[C@H1]2COC3=CC=CC=C32)CN(C(=O)C4=NNC(=O)C4)C1 C[C@@H1](NC(=O)C=1C=C[NH1]N=1)C(C)(C)C(=O)NCC2=CC=CC(O)=N2 C#CC[C@@H1](CC(F)F)C(=O)NC[C@](C)(O)CNC(=O)[C@H1]1C[C@@H1](C)N(C)C1 CCC12COC(C(=O)N3CCC(O)(CN(C)C(=O)[C@H1]4CCCC4(F)F)CC3)(C1)C2 C[C@H1](CNC(=O)[C@H1]1CCSC1)NC(=O)CNS(=O)(=O)C2=CC=C(F)C=C2 CSC1=CC=NC(CN=C2[NH1]C3=C(C(=NCC=4N=C(C)SC=4C)[NH1]2)CSC3)=C1 CC1=CC=2[NH1]C(C(=O)N[C@@H1]3CC[C@H1]3NC(=O)[C@@H1]4CCCCN(C)C4=O)=CC=2S1 CCN(CCNC(=O)C[C@@](C)(O)C1CC1)C(=O)C=2C(C)=NN(CC)C=2Cl O=C(CSC1=NN=CN1C2CC2)N3C[C@@H1]4C[C@H1](C3)N4C(=O)[C@@H1]5CC[C@H1]6CC[C@H1]5O6 CC(C)[C@H1](CNC(=O)CNS(=O)(=O)C1CC1)NC(=O)CCC(F)F CO[C@@H1]1C[C@@H1](CNC(=O)C2=CC=CC(C3(F)COC3)=C2)N(C(=O)/C=C/C(C)C)C1 CSCCC(C)(C)NC(=O)[C@@H1]1CCC[C@@]2(CCOC2)O1 COC1=CC(C#N)=CC=C1CNC(=O)[C@H1]2CCC3=CC=CN=C32 C=CC(C)(C)CC(=O)N[C@@H1]1CN(C(=O)[C@H1](O)CCC2=CC=CC=C2)C3(CCC3)C1 C#CCCN(C)CC(=O)NCCCN(C(=O)CN(CC)CC)C(C)C CC1=C(C(=O)N[C@@H1](CNC(=O)C=2C=C(Cl)N(C)N=2)C3CC3)C=NN1C(C)C CCCN(CCNC(=O)[C@H1]1CCCCC12CC2)C(=O)C3=CC(C)=NC(C)=N3 CC1=CC(C(=O)N(C)C[C@H1](C)NC(=O)CC2=CC=CC=C2C(C)C)=C[NH1]1 CN(C[C@@H1]1C[C@H1](F)CN1C(=O)C[C@H1]2CCCNC2=O)C(=O)C3=C[C@H1]4CC[C@H1]3C4 CCC1(C#CC(=O)N[C@@H1]2CC(=O)N(C3CN(C(=O)[C@H1](C)C4CCCCC4)C3)C2)CC1 CC1=NN=C(CC(=O)N=S2(=O)CCC3(CC2)CN(C(=O)C=4C=NN(C)C=4)CC3)O1 CNC1=CN=C(C(=O)N2C[C@H1]3CC[C@@]3(CC(=O)NCC4=NOCC4)C2)C=N1 CN1C=C(C(=O)N2CC[C@@H1]([C@@H1]3CCN(CC4=CC=CC=C4)C3)C2)C(C5CC5)=N1 CC1=CN=C(C(=O)NC[C@]2(F)CCCN(C(=O)[C@@H1](F)C(C)C)CC2)N=C1 C#CCN(CCC(=O)N1CCC[C@H1](C)[C@H1]1CCO)C(=O)CCC=2SC=NC=2C CCCN1CCCC[C@@H1]1C(=O)N2CC[C@@H1](NC(=O)[C@@H1](CC)C(=O)OC)[C@H1](C)C2 CNC(=O)CN(C)C(=O)C1=CC=C(CNC(=O)C[C@H1](C)N2C=CN=C2)C=N1 CC1=NC(C2CC2)=NC=C1C(=O)N(C)CCCNC(=O)C3=CC=CC(=O)O3 CC1=CC(Br)=CC=C1S(=O)(=O)N2CCO[C@H1](CNC(=O)C3=CSC=C3C)C2 CC(C)(CNC(=O)C1SCCCS1)C2CCN(C(=O)C3=CC=CC=C3Cl)CC2 O=C(NCCN1C=CC=C1)C2=CC=C(C3=CC=C4OCCCC4=C3)N=N2 CC1=CC=C(CCC(=O)N2C[C@@H1]3[C@H1](C2)[C@@H1]3NC4=NC=NC5=CC=C(F)C=C45)S1 CCCC[C@@H1](O)CC(=O)N[C@@H1](C)C(C)(C)NC(=O)C1=CC(O)=CC(Br)=C1 CC=1N=C(CNC(=O)C2=CC(F)=CC=C2F)OC=1C(=O)O CC1=NC=C(C(=O)N[C@H1]2CN(C(=O)C3=C(C)C=NN3C(C)C)CC(F)(F)C2)S1 CCCC(=O)N1C[C@@H1](OC)C[C@H1]1CNC(=O)[C@@H1]2CCCC[C@@H1]2C=3N=C[NH1]N=3 COCCN=C(NCCOC1=CC=C(F)C(Cl)=C1)N[C@@H1]2C[C@H1]2C3=CC=C(C)C=C3 COC1=CSC=C1C(=O)N2CC[C@](C)(NC(=O)[C@H1](C)OC3=CC=C(F)C=C3)C2 CNC(=O)C[C@H1]1CCCN(C2=CC=NC(N3CCC([C@H1]4COC(=O)N4)CC3)=N2)C1 CC1=NC(C(C)(F)F)=CC=C1C(=O)N2CC[C@@H1](CO)[C@H1](NC(=O)[C@@H1]3C[C@@H1]3C#N)C2 O=C(C=1C=CSC=1)N2CC[C@H1]3CN(C(=O)C4=CN=C5N=CC=CN45)[C@@H1]3C2 CC1(O)CCC(C(=O)NCC2=CC(C(=O)N3CC(=O)NC[C@@H1]3C(N)=O)=CS2)CC1 COC(=O)C1=C(Br)C=CC=C1NC(=O)[C@H1]2C[C@H1]3C[C@@H1]3N2CC4=CC=NC(Cl)=C4Cl O=C(N[C@@H1]1C[C@H1]2CC[C@@H1]1[C@@H1](NC(=O)C=CSC3=CC=CC=C3)C2)C4=COC(Cl)=N4 C=CCC1(NC(=O)C2=CC=NC=C2CC)CN(C(=O)C34CC(C[C@H1](C)O3)C4)C1 O=C(O)[C@@H1]1CC12CCN(C(=O)C3=CN4C=CC(Br)=CC4=N3)CC2 COCC(=O)N1C[C@H1](NC(=O)C2=CC=CC(N(C)C)=N2)[C@@H1]3C[C@@H1]31 CO[C@H1](CN[C@@H1]1CCC=2N=C(C3CCCCC3)[NH1]C=2C1)[C@@H1]4CCCOC4 COC1=CC=C([C@@H1](NC2=CC=C3N=C(O)OC3=C2)C(C)C)C=C1F COC1=CC=CC2=C1N=C(NC(=O)N3C[C@@H1](N4CCOCC4)C[C@H1](C)C3)N2C C#CCC(CC#C)C(=O)N(C)CCOCCCNC(=O)C=1OC=CC=1C CC1=CN=C2C(C(=O)NC[C@H1]3CN(C(=O)[C@H1]4CCCC45CC5)C[C@H1]3O)=CC=CN12 C=CCCOCCNC1=CC(Br)=CC=C1S(=O)(=O)N(C)CC(C)(C)CN(C)C CC1=COC=C1C(=O)NC[C@H1]2CN(C(=O)CC(F)(F)Cl)CC3(CCC3)O2 C[C@@H1](C(=O)N1C[C@H1](NC(=O)CCOC2=CC=CC=C2)CC(C)(C)C1)N3C=NN=N3 C[C@@H1](NC1=CN=CC(C#N)=N1)[C@H1](O)C2=CC=CC3=CC=CC=C23 CC#CC[C@H1](NC(=O)CC(=O)NCC)C(=O)N(C)C1CC(=C)C1 CN1C([C@@H1](O)C2=CC=CC=C2)=NN=C1N(CCC3CC3)CC4=CC=CC=N4 CCCN1C=C(C(=O)N[C@H1](C)C(=O)NC[C@H1](F)C2=CC=CC=C2)C=N1 NC1=C(Cl)C=CC=C1C(=O)N2C[C@@H1]3C[C@]3(CNC(=O)CCOC4CCC4)C2 CN(C(=O)C1=COC(CC2CC2)=N1)C3CN(C(=O)C4([C@@H1]5CCCO5)CCC4)C3 CCN(CC)C[C@@H1](F)C(=O)N1C[C@H1](NC(=O)C=CC2=CC=CO2)C(C)(C)C1 COC1=CC=C(CN(C)[C@@H1](C(=O)NC(C)(C)C)C2=CN=CC(C(C)C)=C2)C(Cl)=C1 CCC1=CN=CC=C1C(=O)N[C@@H1]2C[C@H1]2CNC(=O)C=C(C)C(C)C C#CCSCC(=O)N1C[C@@H1](NC(=O)C2=CN(C3CC3)N=N2)C[C@@H1](F)C1 CCN1C=NN=C1C(=O)N2CC(O)(C(C)(C)CNC(=O)[C@H1]3CNC(=O)C3)C2 COC1=CSC=C1C(=O)N2C[C@@H1](NC(=O)C3=C4C(=NN3C)CCOC4)[C@H1](SC)C2 CC1=NSC(N[C@H1]2CN(C(=O)[C@@H1]3C[C@@H1]4C[C@@H1]4C3)CC2(C)C)=C1C#N CCOCCO[C@H1](C)C(=O)NCC=1OC=CC=1C(=O)N[C@H1](CN(C)C)C(C)C C=CCCOCC(=O)N1[C@H1]2CC[C@H1]1CN(C(=O)[C@@H1]3CN4CCCN3CC4)C2 C[C@@H1](CNC(=O)CCCC1=CC=CC(Br)=C1)CNC(=O)C2=C(Cl)CCOC2 CC1(C)C[C@H1](NC(=O)C=2C=CSN=2)CN1C(=O)C3=COC4=C(F)C=C(Cl)C=C34 CC=C(CC)C(=O)N1CCC[C@H1]1[C@@H1]2CCCCN2C(=O)CCC3=CC=C(O)N=N3 COC(=O)C1=COC(C(=O)N[C@H1]2CCC[C@H1]2NC(=O)[C@H1](NC(C)=O)C(C)(C)C)=C1 CCC1=C[NH1]N=C1C(=O)N[C@H1](C)[C@@H1]2CCN(C(=O)COC3=CC=C(F)N=C3)C2 O=C(N[C@@H1]1CCCN(C(=O)C[C@@H1]2CC[C@H1]3C[C@@H1]23)CC1)C=4C=NN5C=CN=CC=45 CSCC[C@@H1](O)C(=O)N1[C@H1]2CC[C@H1]1CN(C(=O)C[C@@H1]3CCNC3=O)C2 CC1=N[NH1]C=C1C2=CN=C(CNC(=O)C3=C(F)C=CC=C3I)N=C2 C#CCOCC(=O)N[C@@H1]1C=C[C@H1](CNC(=O)C2=C(C)N=CN2OC)C1 O=C(N[C@H1]1CCN2N=CN=C2C1)[C@@H1]3C[C@@H1]4CCC[C@@H1]4N3C(=O)[C@@H1]5C[C@@H1]6CC[C@@H1]6C5 C[C@@H1](NC1=CC=C(Cl)C=C1Cl)C(=O)NCC2(C)COC2 COCCN1N=NN=C1[C@H1](NCC(C)(C)C(=O)OC)[C@@]23CCC[C@@H1]2C3(F)F CC=1N=C(CO)SC=1C(=O)NC[C@H1]2COCCN2C(=O)CN3CCOC3=O CCCC1=CC=C(C(=O)NC[C@](C)(O)CNC(=O)C[C@@H1]2CC(C)(C)CO2)C=C1 COC1=NC=CC(C(=O)NC2CCN(C(=O)[C@@H1](C)N3CCNC3=O)CC2)=N1 COCCC1=CC(C(=O)N2C[C@H1](NC(=O)CCNS(C)(=O)=O)[C@@H1](SC)C2)=NO1 C[C@H1](C(=O)N1CCN(C(=O)C2=C[NH1]C=C(Br)C2=O)[C@H1](CF)C1)C(C)(C)C C#CCCCC(=O)N1CC[C@H1](NC(=O)[C@H1](CC)NC(C)=O)[C@H1](CC)C1 CC=1OC=CC=1C(=O)NCCCN(CCO)C(=O)CN2CCCC[C@H1](O)C2=O CN(C)CCCCCN[C@H1](C1=NN=NN1CC2=CC=C(F)C=C2)[C@@H1]3CCCOC3 O=C(CN1CCCC1=O)NC[C@H1]2C[C@](F)(CNC(=O)C=3C=C4N(N=3)C[C@H1](F)C4)C2 C[C@@H1]1CCN(C(=O)C=2C=C[NH1]C(=N)C=2N)C[C@H1]1NC(=O)C=3C=COC=3Br CC1=CSC(C(=O)N2CC[C@@H1](CNC(=O)[C@]3(C)COCCO3)C2)=C1 C#CC[C@H1](C)C(=O)N[C@H1]1C[C@@H1](CCNC(=O)C2=CC=C3C(=C2)OC(C)(C)C3)C1 COC1=CC=C(C)C(C(=O)NC2CC3(C2)CC(NC(=O)C4CC(C)(O)C4)C3)=N1 CC1=CN=C2C=C(C(=O)N3CCN(C(=O)C4=CC=NC=N4)CC35CCC5)C=CN12 O=C(N[C@H1]1C[C@@H1](CNC(=O)[C@@H1]2C[C@H1]2[C@H1]3CCCO3)C1)C4=CC5=C(N=N4)CCCO5 CC[C@@]1(C)CCN1[C@H1](C(=O)NC2=CC=C(OC)C=C2)C3=CC=CC(C(C)(F)F)=C3 C=C1CCN(C(=O)[C@@H1]2CCN(C(=O)C3=CC=C(Br)C=C3[N+1](=O)[O-1])C2)CC1 C#CC1=C[NH1]N=C1C(=O)N[C@@H1](CN2C=CC=N2)C(=O)N3C[C@H1]4CC[C@@]4(CO)C3 CCNC(=O)CCCC(=O)NCC1(C2(O)CN(C(=O)C[C@H1]3CC3(Cl)Cl)C2)CC1 CC1=NC(CC(=O)N2CC[C@](O)(C(=O)NC3=CC=C(Br)C(C)=C3C)C2)=CS1 C[C@@H1]1[C@H1](NC(=O)C(F)(F)CC2CC2)CCCN1C(=O)CC3=CCOCC3 C[C@](CNC(=O)C=1C=CC2=NC=NN2N=1)(NC(=O)[C@H1]3CC[C@](C)(O)CC3)C4CC4 CC(C)C[C@@H1](C)C(=O)NC[C@@H1]1CN(C(=O)C23CC(C)(C2)OC34CCC4)CC15CC5 CC1=CC=C(Cl)C(F)=C1C(=O)N2C[C@H1](C)[C@@H1](NC(=O)CN(C)C(N)=O)C2 CN1C(=O)CCC[C@H1]1C(=O)N2CC[C@]3(CCN(C(=O)C4CC=CC4)C3)C2 CN(C(=O)CCC1=CSC=N1)[C@@H1]2CCN(C(=O)[C@H1]3CCCC=4N=C[NH1]C=43)C2 CCOC1(CNC(=O)C#CC2CCCC2)CN(C(=O)CNC(=O)CC(C)(C)C)C1 CCC[C@H1](CC)CC(=O)N1CCCC[C@@H1](CNC(=O)[C@@H1]2CC=CCO2)C1 CC1=CC(C(=O)N2C[C@H1]3C[C@H1]2CN(C(=O)[C@@]4(C)CC(C(F)(F)F)=NO4)C3)=NS1 C[C@H1](C(=O)N[C@@H1](C(=O)NCCCN1C=CC=N1)C2=CC=CO2)C3=CN=CN=C3 CCSC1(CNC(=O)COC2CN(C(=O)C3(C4(C)CC4)CC3)C2)CC1 C[C@H1]1CN(C(=O)C2(CO)CC(C)(C)C2)C[C@@H1](C)[C@@H1]1NC(=O)CCC=3C=NN(C)C=3 CC1=CC=C(F)C(C(=O)N2CC(CO)(NC(=O)CC3=CC=C4SC=CC4=C3)C2)=N1 C[C@@H1](CCC1=CC=CC=C1)CC(=O)NC2(CO)CCN(C(=O)CC[C@H1](C)O)CC2 CC=1SN=NC=1C(=O)N2CCC[C@@H1]2CCC(=O)N3CC4(CCC4)C3 CN1C(=O)CCC[C@@H1]1C(=O)N2CC[C@H1]2C(=O)NCCC3=NC=CC=N3 C[C@H1](NC(=O)CCN1CC[C@H1](F)C1)C2CN(C(=O)C3(C(F)(F)F)CCC3)C2 CC=1C(C2=CC=C(CCC(F)(F)F)C=C2)=N[NH1]C=1C3CC3 CC1=CC=C2[NH1]C3=C(C2=C1)CCC[C@H1]3N(C)N4CC[C@@]5(COC(=O)N5)C4 C[C@@H1]1[C@H1](NC(=O)[C@@H1]2C[C@H1]3C[C@@H1]2C[C@H1]3O)CCCN1C(=O)CCNC(=O)CO CCN(CC)CCNC(=O)C1=NO[C@@H1](CNC(=O)[C@H1]2CCCC(=O)N2C)C1 CC(C)(C)CC(C)(C)C(=O)NC[C@@H1]1C[C@@H1]2CCC[C@@H1]2N1C(=O)C3=CC=CN=C3N CC[C@@H1]1C[C@H1](C(=O)NC/C=C/CNC(=O)C2=CN=CC(C(=O)OC)=C2C)CCO1 NS(=O)(=O)C1(C(=O)N2CCC[C@@H1]2CCOC(F)(F)F)CCC1 C=CC[C@@H1](C)C(=O)N1C[C@H1](NC(=O)C(C)(C)CC(F)F)CC2=CC=CC=C21 C[C@H1]1CCC[C@H1]1CC(=O)NC2(C(=O)NCC(C)(C)CN=[N+1]=[N-1])CSC2 C=C(Cl)CN1C[C@@H1](NC(=O)C2=CSC(C3=CC=C(Cl)C=C3)=N2)CC[C@H1]1C CC=1OC=CC=1CC(=O)N2CC3(CCN(C(=O)[C@@H1]4CC(C)(C)CO4)C3)C2 COC[C@@](C)(O)CC(=O)N[C@@H1](CC1=CC=C(O)C(F)=C1)C(=O)O CC(C)CC1=CN=C([C@@H1](NC[C@]2(Br)CC2(F)F)C3=NN=NN3CCCC4CC4)S1 CC=1C=CN2N=CC(C(=O)N3CCC[C@H1](NC(=O)[C@@H1](C)C4CC4)[C@H1]3C)=C2C=1 CC=CC=C[C@@H1](C)N=C1C=CN2N=CC(S(=O)(=O)N[C@H1](CO)CCF)=C2[NH1]1 C[C@H1](CC(=O)N[C@@H1]1CN(C(=O)C2(O)CCCC2)C[C@H1]1S(C)(=O)=O)C3=CC=CC=C3 C[C@@H1](CNC(=O)C1(C(C)(F)F)CCOCC1)CN(C)C(=O)[C@@H1]2[C@H1]3CCCCC[C@H1]32 CCN(C[C@@H1](C)NC(=O)[C@@H1](C)C1=CC=C(OC)C=C1)C(=O)[C@H1]2C[C@](OC)(OC)C2 COC1(C(=O)N[C@H1]2C[C@H1](CNC(=O)C3=CC(OC)=C(Cl)C([N+1](=O)[O-1])=C3)C2)CC1 O=C(CC=1SC=CC=1Cl)N[C@@H1]2C[C@H1]2NC(=O)C=3C=C(C4=CC=CC=C4Cl)ON=3 CCCC=CC(=O)NC[C@@H1]1CCN(C(=O)C2=C(Br)C=NN2C)C1 CC=1C=C(CN(C)C(=O)[C@@]2(O)CCN(C(=O)C3=CC=C(C)C(O)=C3)C2)ON=1 C#CC=1C=NN(C)C=1C(=O)N[C@H1]2CC[C@H1](NC(=O)C3=CC=CC4=C[NH1]N=C34)CC2 C#CC(C)(C)NC(=O)[C@H1](CC1=CC=CO1)NC(=O)[C@H1]2C[C@@H1](N(C)C)C2 CC1=NN=C2C=CC(C(=O)N[C@@H1]3CN(C(=O)[C@H1]4C[C@@H1]4C)CCC35CCC5)=CN12 COCC1=NC(C)=CC(=N[C@H1]2C[C@](F)(CNC(=O)C3=CC=4SC=CC=4S3)C2)[NH1]1 COC(=O)C1=CC=C(NC(=O)C2=CSC(C3=CC=C(C)C(C)=C3)=N2)C(OC)=C1 CCC1=NOC(CCC(=O)N(C)[C@H1](CNC(=O)C2=CN=C(C)[NH1]2)C3CC3)=N1 C[C@H1](CCN(C)C(=O)COC1=C(F)C=CC=C1F)NC(=O)CN2CCCCC2=O CCC[C@H1](NC(=O)C[C@@H1](C)N1C=CC=N1)C(=O)NC[C@H1](C)C2=CC=CC=N2 COCC(=O)NCC1=NN=C2N1CCN(C(=O)[C@@H1](C)OC3=CC=CC=C3C#N)C2 CO[C@]1(CNC(=O)C2=NNC(=O)C2)CCN(C(=O)C=3C=C4C=CC=CN4N=3)C1 CC[C@@H1](C(=O)N1CCCC[C@H1]1CNC(=O)C[C@@H1]2CCCC[C@H1]2O)C3CCOCC3 CCC1(NC(=O)[C@H1]2[C@@H1](C3CC3)CCN2C(=O)C=4C=N[NH1]C=4)CCCCC1 CCN(C[C@H1]1CCCCN1C(=O)C2=CN=C(O)O2)C(=O)C3CC(Cl)(Cl)C3 NC1=CC=CC(C(=O)N2CCC3(CC2)OCC[C@H1]3NC(=O)CC4=CC=CS4)=C1 C[C@H1](CNC(=O)C1=CC=NN1C)C2CCN(C(=O)CN3C=NN=C3)CC2 CC1=NC(O)=NC(O)=C1CCC(=O)N2CC=C[C@@H1](NC(=O)[C@H1]3CSCCS3)C2 CC[C@H1](C)CC(=O)NCC[C@H1]1CN(C(=O)CC2=CC=C(C)C=C2)CCO1 N=C1[NH1]C(=NCC[C@@H1]2COC[C@H1]2O)[NH1]C(=N[C@@H1]3C[C@H1](O)CC(C)(C)C3)[NH1]1 COC1=CC=C(C)C(OC)=C1CN[C@H1](C2=CC=CC=C2)[C@@H1](C)N CC1=NC(CC(=O)N[C@@H1](CO)CNC(=O)C(C)(C)NC2=CC=CC=N2)=CO1 C[C@]1(CNC(=O)C2=CC=C(C#N)[NH1]2)CC[C@H1](NC(=O)C3=CN=C4C=CC=CN34)C1 CC(C)(C)C(=O)N1CCN(CC2=C(Cl)C=C(F)C=C2Cl)CC13CC3 C/C=C/C[C@H1](C)C(=O)N[C@H1](CC(=O)N1CCN(C)C[C@H1]1C(C)C)CC(C)C C#CCC[C@H1](NC(=O)[C@@H1](C)[C@H1](O)C(C)C)C(=O)NCC=CC CCN1C=NC(C(=O)N[C@@H1]2C[C@H1](C(=O)NC[C@H1](O)C(C)C)C2(C)C)=N1 CC1=NC=C(CN2C[C@@H1]3[C@H1](C(=O)NC4=CC=CC(S(N)(=O)=O)=C4)[C@@H1]3C2)[NH1]1 COC(=O)C1=CN=CC(C(=O)N[C@@H1](C)CCNC(=O)[C@H1]2CCCO2)=C1 CCC(C)=C(C)C(=O)NC[C@]12C[C@H1]1CN(C(=O)[C@@]3(OC)CCOC3)C2 CC1=CN=CC(C(=O)N2CCC[C@H1](C)[C@@H1]2CNC3=CC(O)=NC=N3)=C1C CC[C@@H1]1CCCC[C@H1]1C(=O)NC[C@]2(F)C[C@H1](N=C3[NH1]C=NC(Cl)=C3F)C2 CC(=O)OCCC(=O)N[C@@H1](C)C[C@H1](C)NC(=O)CC1=CC(Cl)=CC=C1Cl CCOC(=O)[C@H1](NC(=O)OC(C)(C)C)C(=O)N1C[C@@H1]2C[C@H1]1CN2C3=NC=NN3C C[C@H1]C1N(C(=O)[C@H1]C[C@@H1](C)CO[C@@H1])CCCN1C(=O)C2=CN=C3C(=C2)NC(=O)CO3 C[C@H1](CC(=O)NC[C@@]1(C)CCCN1C(=O)[C@]2(F)CCOC2)C3=CC=CO3 CC[C@H1](NC(=O)N[C@@H1]1CCOC2=CC(F)=CC=C21)C3=NC=C(Br)C=N3 CC[C@@H1]1C[C@H1](O)CN1C(=O)C[C@H1](C)CNC(=O)C2=CN(C(C)C)C=N2 COC(=O)[C@H1]1C=C[C@H1]1C(=O)N2C[C@H1]3CC[C@H1]2C[C@@H1]3NC(=O)C[C@@H1]4COC[C@H1](C)O4 COC1=CC=CC(CNC(=O)[C@@H1](C2=CC=C(Br)C=C2)N3CC4CC3C4)=N1 O=C1COC2(CCN(C3=NC=NC4=C3N=CN4CC5(O)CC5)CC2)N1 CC=1OC(C)=C(C(=O)N2C[C@@]3(C(=O)NC[C@@H1]4CCC(C)(C)CO4)C[C@H1]2CO3)C=1C C[C@]1(C(=O)NC[C@@H1]2C[C@H1]3CC[C@H1]2N3C(=O)[C@@H1]4CC5CCC4CC5)C[C@H1]6CC[C@H1]1C6 CN=C1[NH1]C=C(C(=O)NCC2[C@@H1]3CN(C(=O)CNC(=O)CC(C)C)C[C@@H1]32)S1 O=C(N[C@H1]1CCC[C@H1]1NC(=O)[C@H1]2CC=CC3=CC=CC=C32)C4=CC=5OC=CC=5S4 CC1=CC=C(CN(C)S(=O)(=O)C2=CC=C(N[C@H1]3CC[C@]4(C3)CC4(F)F)N=C2)N=C1 CC1=NC=CN1CC(=O)NCCCN(C)C(=O)[C@@]2(C)CCC(C)=C(C)C2 C[C@@H1](CF)C(=O)N[C@H1]1CCCCCN(C(=O)C=2C=C(C3CCOCC3)ON=2)C1 C[C@H1](O)[C@@H1](C)C(=O)NCCCC1(NC(=O)COC2=CC=C(C(N)=O)C=C2)CC1 CC[C@@H1]1[C@@H1](NC(=O)CCCC2=CSC(C)=N2)CCN1C(=O)C3=CN(C)[NH1]C3=N C=CN1N=CC=C1C(=O)NC[C@H1]2CC3(CCN(C(=O)C=4C=C(C)SN=4)CC3)CO2 CC[C@@H1]1CCO[C@@H1]1C(=O)N2CC[C@@](O)(CNC(=O)CCC3=CC=NN3C)C2 CCSCCNC(=O)[C@H1]1[C@@H1](CNC(=O)C2=NC=NC=C2N)C1(C)C COC1(C(=O)N2CCCN(C(=O)CC=3C=COC=3)[C@H1](CO)C2)CC1 COC1=NC=C(Cl)C(N2C[C@@]3(C)CN(C(=O)CC[C@H1](C)OC)C[C@@]3(C)C2)=N1 C/C=C/C[C@H1](CC)C(=O)N1CCCN(C(=O)[C@H1]2[C@H1]3CC[C@@]2(C4=CC=CO4)C3)CC1 C#CCCCCCCNC(=O)[C@@H1]1CC[C@H1](C)N1C(=O)C2=NC=CC=C2F CO[C@H1](C)CCC(=O)N1CC[C@H1](NC(=O)C2=CN(C3COC3)N=N2)[C@H1]1C CC=1[NH1]C2=CC=CC=C2C=1C(=O)N[C@@H1]3CCC[C@H1](C)N(C(=O)C4=C(Cl)CCC4)C3 CCN(C[C@@H1](C)NC(=O)C1=CC=C2C(=C1)[C@H1]3CC[C@H1]2O3)C(=O)C4CN(C)C4 COC1=NC=C(C(=O)N2C[C@@H1](F)C[C@@H1]2C(=O)N[C@@H1](C)C3=CC=NO3)C=C1C C=C[C@H1](O)C(=O)N1CCSC[C@H1]1C(=O)NC2=CSC=C2CC CO[C@@H1](CNC(=O)[C@H1]1C[C@H1]2C=C[C@@H1]1CC2)C(=O)NC[C@@H1]3[C@H1](CO)C3(F)F CC=1SC(O)=NC=1C(=O)N2C[C@H1]3CN(C(=O)[C@@]4(C)C[C@H1](O)CN4C)C[C@@]3(C)C2 O=C(NC[C@@H1]1CCOC1)[C@H1](C=2C=NSC=2)N3CC[C@@H1](N4CCCC4)C3 CO[C@@H1]1CN(C(=O)C2=CC=C(C(F)F)C=C2Cl)C[C@H1]1NC(=O)C=C(C)C(C)C CCCCCCOC1=CC(C)=CC=C1CNC[C@@H1](O)C2=CC=CC(S(C)(=O)=O)=C2 C[C@H1]1CC=C(C(=O)N[C@](C)(C(=O)N[C@H1](C)CCC=2C=N[NH1]C=2)C3CCC3)CC1 CN(C)C1=CC(NC(=O)NC2CN(CC(=O)N(C)C)C2)=NC=N1 CC(C)(C)OC(=O)N1C[C@]23CCCC[C@]2(C1)CN(CC4=C(Cl)C=CC=C4Br)C3 CC(C)(C(=O)NCC1=NC=CC(O)=N1)[C@@H1]2CCCN2C(=O)[C@H1](F)C3CCCCC3 CC1=CC=C(Br)C=C1CC(=O)N[C@H1]2CN(C(=O)[C@H1]3CNC(=O)N3)CC2(C)C CCC(CC)C(=O)N1CCN([C@H1]2CCN(C(=O)[C@H1](C)C3=CC=NN3C)C2)CC1 CC[C@@H1]1C[C@H1](C(=O)N[C@H1](CC(F)F)C(=O)NCCC(C)(C)C2CC2)CCO1 CO[C@@H1]1CN(C(=O)C2=C(F)C=NC=C2Cl)C[C@H1]1NC(=O)C3=CC=C(N)C(C)=C3Cl CN1N=CC=2C=C(C(=O)N[C@H1]3CC(=O)N(C4CN(C(=O)COC5CC5)C4)C3)SC=21 NS(=O)(=O)C1=CC=C(CNC(=NCCN2CCCC2)NC[C@@H1](F)C(F)(F)F)C=C1 O=C(N[C@H1]1CN(CC2=CSC=C2Br)CCC1(F)F)C3=CN=C(Cl)C(C(F)(F)F)=C3 CN1C=C([C@]2(CN[C@H1]3CC[C@H1](C4=NC=C[NH1]4)CC3)CCCO2)C=N1 COC[C@@]1(N)CCN(C(=O)CC2=CSC(C3=CC=CC(Br)=C3)=N2)C1 C=CCSCC(=O)N[C@@H1](C)[C@@H1]1C[C@H1]1C(=O)N[C@H1](C)C2=CN=C[NH1]2 C=C(CCNC(=O)C1=CC(Cl)=NO1)CNC(=O)C2=CN3C=CC=C(Cl)C3=N2 CC1=NON=C1CC(=O)N2CC3(C[C@H1](NC(=O)[C@H1]4CCC(=O)N4)CO3)C2 CC(C)C=1OC=NC=1C(=O)N(C)[C@@H1]2CCCN(C(=O)CCOCC3CC3)CC2 CC=CC(=O)N[C@@H1](C)C[C@@H1](C)NC(=O)C1=CC(Cl)=C(F)C=C1[N+1](=O)[O-1] COCC(=O)NC1CN(C(=O)[C@@H1]2CCCC[C@]2(C)NC(=O)CC3=NOC=C3C)C1 CCCC1(C(=O)NC2CC3(C2)C[C@H1]3NC(=O)C=4SC(=N)[NH1]C=4CC)CC1 C[C@@H1](NC(=O)C[C@@H1](O)C1=CC=C(Cl)C(Cl)=C1)C2=CC=C(S(C)(=O)=O)C=C2 CN(C[C@@H1]1CCCN1C(=O)CCC2=CC=C(Cl)C=C2)C(=O)C(F)(F)C3=CSC=N3 CC[C@H1](C(=O)N1C[C@@H1](O)[C@H1](N(C)C(=O)CC2=CC(C)=NO2)C1)C=3C(C)=NOC=3C CSC1=CC(C)=NC(N(C)CC2=CC=CC(C3=CCS(=O)(=O)CC3)=C2)=N1 CC(C)N1C[C@H1](C(=O)N2CC(CNC(=O)C3=CC=C(F)N=C3F)C2)CC1=O CC[C@@H1](C(=O)N1CC[C@H1](NC(=O)CC23COC(C2)C3)C[C@H1]1CC)N4C=CN=C4 COC(=O)C(C)(C)CC(=O)N1CC[C@@H1](NC(=O)C2(CO)CCOCC2)[C@H1](O)C1 CCOCCOCCC(=O)N1CC(C2=CN([C@H1](C)C3=CC=CN=C3)N=N2)C1 CCC1CCC(CN[C@@]2(C3=NN=NN3C)CCN(C)C2)CC1 COC(=O)C1=CC=C(NC2(CNC(=O)C3=CSN=C3C)COC2)N=C1 CC1=CC=C(CC2(NC3=NN=C(C4(O)CSC4)S3)CCCC2)C=C1 O=C(CCC1=CC=C2C(=C1)CCO2)NCCNC(=O)C3(O)CC3 CCC1=CC=CN=C1C(=O)N(C)CC[C@@H1](NC(=O)C=CC2=CN=CN2C)C(C)C C[C@@H1]1C[C@H1](N(C)C(=O)[C@]2(C#N)C[C@@H1]2C(F)(F)F)CCN1C C=CCOCCN(C)C(=O)[C@H1]1CCN1C(=O)C2=C(C)C=C(O)N=C2C CC[C@@H1]1CCC[C@]1(C)C(=O)N2CC(CNC(=O)/C=C(C)C)(C(N)=O)C2 CN(C(=O)CC1=CN=CC(Br)=C1)C2CN(C(=O)CC(F)(F)C(F)F)C2 COC1=CC=C(OCCCC2=NC(C3=CC=C(N)C=N3)=NO2)C=C1 COC1=CN=C(Cl)N=C1N2C[C@H1]3C[C@H1](NC(=O)CCC4=CC=NC=N4)CC[C@H1]3C2 C=CCCC(=O)N[C@H1]1C[C@@H1](CNC(=O)C=2C=CN(C)C=2C3=CC=CC=C3)C1(C)C CN1N=C2C(=C1C(=O)O[C@H1]3COC[C@@H1]3C4=CC=CC=C4)COCC2 CN1N=CC2=NC=NC(NCC3CN(C(=O)[C@@H1]4C[C@H1]4C5=CC=C(F)C(F)=C5)C3)=C21 CSCC1=CC=CN=C1C(=O)N[C@H1]2CCOC[C@H1]2NC(=O)CC3(C#N)CCC3 CC1=NC(COC(=O)C=2N=C(C3=CC=CC=C3)N4C=2CCNCC4)=N[NH1]1 CC[C@H1](C)C(=O)NCC1=N[NH1]C=C1C(=O)NCC(CC)(CC)CO O=C(N[C@@H1]1C[C@H1]1CNC(=O)C2CC3(CCC3)C2)C4=N[NH1]C5=CC=CC=C45 C#CC(C)(C)C(=O)N1CCC([C@@H1](F)CNC(=O)[C@H1](OCC)C2=CC=CC=C2)CC1 C[C@@H1]1C[C@@H1]1[C@H1]2C[C@@H1]2NC(=O)NCC3=CC=CC=C3OCC#N CCOCCN1N=NN=C1[C@@]2(N[C@H1]3CCC4=CC=C(Cl)N=C43)CC[C@H1](CC)C2 CC1=CC(Cl)=C(C(=O)N2CC(O)([C@H1](C)NC(=O)[C@@H1]3C[C@H1]4[C@@H1](C3)C4(F)F)C2)C=C1N CC(C)OC1=NC=CC=C1C(=O)NC[C@@H1](F)CNC(=O)C[C@H1]2CCCC2(F)F CCC=C(CCC)C(=O)N1CCCN(C(=O)[C@@]2(F)CCOC2)C[C@H1]1C COCC[C@@H1](OC)C(=O)N1C[C@H1](N=[N+1]=[N-1])C[C@@H1]1C(=O)N(C)CCC2CCCC2 CC(=O)NCCC(=O)N1CCN2N=C(C(=O)NC3=CC=NC(Br)=C3)C=C2C1 C[C@@H1](C#N)C(=O)N1CCC[C@H1](CC2=CN(C3=C(Cl)C=CC=C3[N+1](=O)[O-1])N=N2)C1 CCOC1=CC(CN2CC[C@@H1]3C[C@@H1](C(=O)N(C)CCOCCO)[C@@H1]3C2)=CC=C1Br C=CC[C@H1](CNC(=O)C1CCCCCCC1)C(=O)NC2=CN=C(C(C)C)N=C2 COC1=CC=C(NC(=O)C(=O)N2CCC[C@H1](CCNC(=O)C3(CF)CC3)C2)C=C1 C=C(CCNC(=O)COC(F)(F)F)CNC(=O)C=1C=C(C2=CC=CC(Cl)=C2)[NH1]N=1 CC[C@@H1](CC(=O)N1CC[C@H1](C2CC2)[C@@H1]1C(=O)N3CC4(CCC(=O)O4)C3)C(C)C CCCC1=NC=C(C(=O)N2C[C@H1](OC)C[C@@]2(C)CNC(=O)[C@H1]3C[C@@](C)(O)C3)S1 CCC[C@H1](CNC(=O)[C@H1]1C[C@@H1]1C(C)(F)F)NC(=O)C2=CC=NN=C2C C#CC[C@H1](NC(=O)[C@@H1]1CC12CCN(C(=O)NCCCl)CC2)C3=CC=CC=C3 C#CC1=CC=CC(C(=O)N2CC[C@H1](CNC(=O)C=3SN=NC=3CC)[C@H1]2C)=C1F CC[C@@H1](C)NC(=O)CCNC(=O)C[C@@H1]1CN(C(=O)CC=2C=C(C)[NH1]N=2)C(C)(C)C1 CCOCCC(=O)N[C@](C)(CNC(=O)C1=CC=CC(OCC(N)=O)=C1)C(C)C C[C@@H1]1CCC[C@@H1](C(=O)NCCC(F)(F)CN2C=C([C@@]3(C)CCCO3)N=N2)C1 CCCCC=1N=C([C@@]23C[C@@H1](F)[C@@H1]2C3)N(C4=CC(Cl)=CC=C4C)N=1 CSC[C@H1](C)C(=O)NCC[C@H1]1C2=CC=CC=C2CCN1C(=O)[C@@H1](COC)N(C)C O=C(N[C@]1(CO)CCN(C(=O)C2=CN=C3OC=CC3=C2)C1)C4=CN=C(O)O4 C=C[C@H1](O)C(=O)N[C@H1]1CCCOC12CCN(C(=O)CN3C=C([C@@H1](C)O)N=N3)CC2 C=CC1(C(=O)N2CC(CNC(=O)C3=CSC(CC(C)C)=N3)(C(N)=O)C2)CC1 C[C@H1]1C[C@H1](CCNC(=O)CCC(N)=O)CCN1C(=O)C2=CC=C(C#N)S2 CCC1=CC=NC(C(=O)N[C@H1]2C[C@H1](NC(=O)CCC3=CN(C)C=N3)C2)=C1 CN(C[C@@H1]1CCCN1C(=O)C=CC2CC2)C(=O)CC[C@@H1]3C(=O)NN=C3C4CC4 CC(C)[C@@H1](CNC(=O)/C=C/C(F)(F)F)NC(=O)C[C@H1](C)C1=CC=CN=C1 CCC1=NC(CN2CCC[C@@H1](N(C)C(=O)NC3=CC=C(C#N)C=C3)CC2)=CS1 O=C(/C=C/C(F)(F)F)NCC1(O)CN(C(=O)[C@@H1]2CCC[C@H1]2CC3=CC=CC=C3)C1 COCC1=CC(C(=O)NC[C@H1](C)C2CCN(C(=O)C[C@H1](C)SC)CC2)=NO1 CC1=CC=CC(CSCC(=O)N2CCN(C(=O)C3CC(C)C3)C[C@@H1]2C4CCC4)=C1 O=C(C1=CN=CC(F)=C1)N2CC[C@](O)(C(=O)NCC3(O)CC3)C2 COC(=O)C1=CC=CC(CN(C=O)C[C@H1]2C[C@@]23CCOC3)=N1 CC#CCCC(=O)N1CC2(CO[C@H1](CNC(=O)[C@](C)(CC)OC)C2)C1 O=C(N[C@@H1]1CCCC12CCNCC2)C3=NC=CC4=CC(Br)=CC=C34 CC[C@](C)(CNC(=O)COC1CCN(C)CC1)NC(=O)C2=CN=C(C3CC3)S2 COC=1N=C(C(=O)N[C@@H1](C)CCNC(=O)COC2=CC=CC(C)=C2)SC=1C CC[C@@H1](C(=O)N[C@H1]1C[C@@H1](F)C1)N(C)C(=O)[C@@H1]2CNC(=O)C2 C=C[C@@H1]1CCN1C(=O)[C@H1]2CCCCC[C@H1]2NC(=O)[C@H1]3C[C@@H1](N(C)CC)C3 CS[C@H1](C(=O)N(C)[C@@H1]1CCCN(C(=O)C=CC=2C=N[NH1]C=2)CC1)C3CC3 C=CCC(=O)N[C@]12CCC[C@@H1]1N(C(=O)C=3OC=CC=3C(=O)OC)CCC2 CCCC1=CC=C(CC(=O)N[C@@H1]2C[C@@H1]2NC(=O)C3=N[NH1]C=C3[N+1](=O)[O-1])C=C1 C#CCN1C=CC=C1C(=O)NC23CC(C(=O)NCCOCCN(C)C)(C2)C3 CC(C)(CC(F)(F)F)NC(=O)NC1=CC=C2C(=C1)CCCCC2 O=C(C[C@H1]1CC[C@H1](C2CC2)O1)NC[C@H1]3CCN3C(=O)CCC4=CC=CC=C4F C#CC1=CC=CC(N(C)[C@H1]2CCCN(CC3=CC=CC=C3)C2=O)=C1 CCC[C@@H1]1C[C@H1](C(=O)O[C@@H1]2CCCCC23CCC3)CCO1 CC[C@@H1](OC1CCCCC1)C(=O)N2CCCN(C(=O)C(C)(C)C3=NC=CO3)CC2 CC1=CC=NC(CN=C(N[C@H1](C)C2CC2)N3CC[C@@H1](C(F)(F)F)C3)=C1 CC[C@@H1](F)C(=O)NC[C@@H1]1CC(C)(C)CN1C(=O)C2=CC(C)=CC(O)=N2 O=C(C=1C=C[NH1]C=1)N2CC[C@@](O)(C(=O)NC3=CC=CC(C(F)(F)F)=C3Cl)C2 C[C@H1](CCNC(=O)CC1CCS(=O)(=O)CC1)N(C)C(=O)C=2C=C(C(F)F)N(C)N=2 C[C@@H1]1CCC[C@@H1](C(=O)N2CC=C(CNC(=O)C3=CS(=O)(=O)CCC3)CC2)CC1 CCC1=NC=CC=C1N2[C@H1](C3=CC=C(C)S3)SC=C2C4=CC=CC(F)=C4 COC1=NC=C(Br)C(N2CC[C@H1](C)[C@H1](NC(=O)C3=CC=C(C(C)C)O3)[C@@H1]2C)=N1 CCC[C@@](C)(NCC1=CN=C(C)C(C)=C1)C2=NN=NN2C(C)C CC=1[NH1]C(C(=O)N[C@H1]2C[C@H1](O)[C@@H1](NC(=O)C3=CN=C4N3CCOC4)C2)=C(C)C=1C C[C@H1](CC1CCC1)C(=O)N2CC[C@]3(CCCN3C(=O)[C@H1]4CCN(C5COC5)C4)C2 CCC=1OC=NC=1C(=O)N2CCN(C(=O)CC3(C)CC3)C[C@@H1](CO)C2 C[C@H1](NC(=O)CCC(N)=O)[C@@H1](C)C(=O)N(C)C[C@@H1]1CCCS1 CCCN1C=C(C(=O)N2CCN(C(=O)CN(C)CCO)[C@@H1](C(C)(C)C)C2)C(C)=N1 CCCCN1C=C(C2=NC(C(=O)NCC3=NC(C)=C(C)N3C)=CC=C2OC)C=N1 O=C(CN1CCCC1)N[C@@H1]2C[C@H1]3CN(C(=O)C4=CSC(C(F)(F)F)=N4)C[C@@H1]32 COCCCCCC(=O)N[C@H1]1CCS(=O)(=O)C12CN(C(=O)[C@@H1](C)SC)C2 CCOCCO[C@H1](C)C(=O)NC[C@@H1](O)CNC(=O)[C@@H1](CC)C(F)(F)F CC[C@](C)(CCNC(=O)C1=CC=C(O)N=C1)NC(=O)[C@H1](OC)C2CC(C)(C)C2 C[C@H1](N)C1=CC=C(C(=O)N2CC3(C[C@@H1]3C(=O)NCCC(=O)NC4CC4)C2)C=C1 C=CCONC(=O)CC1CC2(C1)CN(C(=O)C3=CC(F)=CN=C3O)C2 CN1N=CC(C(F)(F)F)=C1C(=O)N2CCN(C(=O)C[C@H1]3CCC3(C)C)C[C@@H1](O)C2 C[C@@H1](C#N)C(=O)N1CCC([C@@H1]2CCCN2C(=O)C=3C=C(C(C)(F)F)ON=3)CC1 O=C(N[C@@]12CC[C@@H1](C1)N(C(=O)C3=CC=4SC=CC=4S3)C2)[C@H1]5CCC6(CCCC6)C5 C=C(Cl)C[C@H1](NC(=O)C[C@H1](CC)SC)C(=O)N[C@H1](C)C1=N[NH1]C(CC)=N1 C[C@H1]1C[C@H1]1C2=CC=C(CNC(=O)CNC(C3=CC=C(Br)C=C3)C4=CC=CC=C4)O2 CSC1=CC(C(=O)N[C@]2(CF)CCN(C(=O)[C@H1]3CCSC3)C2)=CC=N1 CCC1=NC=CN=C1C(=O)N(C)[C@H1]2CC[C@@H1](NC(=O)[C@@H1]3CC4=C(Cl)C=CC=C43)C2 CC1(CNC(=O)[C@H1]2CCC[C@@H1]2O)CCN(C(=O)C=CC3=CC=C([N+1](=O)[O-1])S3)CC1 CN(CCOCCNC(=O)C1=CC(C2CCC2)=NO1)C(=O)[C@]34C[C@@H1]5C[C@@H1]3[C@H1]4[C@H1]5O O=C(N[C@H1]1CCN(C(=O)C2=CC=C(F)N=C2F)C[C@H1]1F)C=3N=COC=3C4CC4 CC[C@H1](C(=O)N1CC[C@H1](C2CC2)[C@@H1]1CNC(=O)CCC3=NC=CN3C)[C@H1](C)O C[C@@H1](C[C@H1](C)NC(=O)C=1C=COC=1C2CC2)NC(=O)C=C3CCOCC3 CC(=O)SCC(=O)N[C@H1]1CCN(C(=O)CC2=CC=C(Br)N=C2)CC1(C)C CC(=O)OCCCC(=O)NCC1(O)CCN(C(=O)C2=CN=C3C=CC=NN23)CC1 CCN1CCC[C@H1]1C(=O)N2CC=C[C@H1](NC(=O)CN=C3[NH1]C(C)=CS3)C2 CCN(CCC(=O)N[C@H1]1CC2(CCC2)[C@@H1]1O)C(=O)CCCCCC#N O=C(C[C@@H1]1C[C@H1]2C=C[C@H1]1C2)N[C@@H1]3CC4=CC=CC=C4[C@H1]3NC(=O)C5=CC=CS5 CCCC(=CC(=O)N1C[C@@H1]2C[C@H1]1[C@@H1]2NC(=O)C3=CN=C(Cl)C(Cl)=C3)CCC O=C(CN1C=C(Cl)C=N1)NCCC2(NC(=O)C3=COC(Cl)=C3)CCC2 CC1(CNC(=O)C=C(C2CC2)C3CC3)CCN(C(=O)C45CSC(C4)C5)CC1 C[C@H1](CCNC(=O)C1=NC=NC(O)=C1F)N(C)C(=O)C23CCN(CC2)CC3 C=CC[C@]1(C(=O)N2C[C@H1](C)[C@@H1](NC(=O)C3=NC=C[NH1]3)C2)CCOC1 CCC[C@@H1](O)CCNC(=O)[C@H1](NC(=O)C1=CC=CC=C1F)C(C)C CC(C)N(CC(=O)N(C)CCN1C=CC=N1)C(=O)CC2=NN(C)C(=O)C2 CCO[C@H1](C)CCC(=O)N1CC[C@H1](C(=O)N[C@@](C)(C(N)=O)C(C)C)C1(C)C C[C@@H1]1OCC[C@]1(F)C(=O)N2CCC[C@@H1](C3CCN(C(=O)[C@H1]4CC(=O)CO4)CC3)C2 CC[C@](C)(C(N)=O)C(=O)NC[C@]1(C)CN(C(=O)CC[S@@](C)=O)C(C)(C)C1 CNC(=O)[C@@H1](C)CN(C)C(=O)C1=N[NH1]C2=C1CN(C(=O)[C@H1](O)C3=CC=CC=C3)C2 O=C(N[C@H1]1CCC2=CC=C(Br)C=C2C1)C3(C4=CC=CC(Cl)=C4)CCC3 C[C@H1]1CCC[C@H1](CNC(=O)C2=CC(CNC(=O)CC3=CC=C(F)C=C3)=NO2)O1 CC1=CC(C(=O)N2C[C@@H1]3C[C@@H1](NC(=O)[C@H1](C)CN(C)C)[C@H1]2C3)=C(C)C=C1Cl CCOCCNC(=O)[C@H1](C1=CC=C(OC)C(Br)=N1)N2CCCOC[C@@H1]2C O=S(=O)(C1=CC=C(N2CCC[C@@H1](CS(C)(=O)=O)C2)C=C1Br)N3CCOC[C@H1](CO)C3 C[C@H1](C(=O)NC[C@@H1](C(=O)NOCC[C@@H1](C)O)N(C)C)C1CCOCC1 CC1=NN=CC=C1C(=O)N[C@H1]2CC=C(C(=O)N3CC(F)C3)C2 COCCCCCCNC(=O)CCOCCN(C)C(=O)[C@H1]1C[C@H1]1Cl C[C@@H1](N=C1N=C2SC=NC2=C(N3CC[C@H1](CF)C3)[NH1]1)C4=NC(C(F)(F)F)=N[NH1]4 O=C(N[C@H1]1CCC[C@@H1](NC(=O)C2=CC(=O)C=C[NH1]2)C1)C3=CC=C(Br)C=C3 CC1(C)CC(C(=O)N2CCOC3(CN(C(=O)[C@@H1]4CCC4(C)C)C3)C2)=NO1 CC1=NOC(C(C)C)=C1C(=O)N2C[C@@H1](CN=C3C=C(Cl)C(O)=N[NH1]3)C[C@H1]2C CC1=CSC(C(=O)NCCNC(=O)COC2CCC(C)CC2)=C1Cl COCC(=O)NCCC(=O)N1CC[C@H1](NC(=O)[C@@](C)(O)CC(F)(F)F)C[C@@H1]1C O=C(C[C@@H1]1CCN(C(=O)C2=CC(I)=C(F)C=C2F)C1)N3CCC4(CC4)C3 N#CC1=CC=CC(C(=O)N2CC3CC2(CNC(=O)C4(C(F)(F)F)CCC4)C3)=N1 CCCN(CCC)CCCC(=O)NCC#CCNC(=O)[C@@](C)(O)C1=CC=CC=C1 N#CC1=CC=C(SCC(=O)NCCCNC(=O)[C@@]2(Cl)CC2(F)F)C=C1 CCCCC1(C(=O)N[C@H1]CC2[C@H1](CN=C3C=C(C(=O)OCC)N=C(Cl)[NH1]3)C2)CC1 CC1(C)C=C2C(=N1)CN(C(=O)C3(N4C=C(C5=CC(Cl)=CC=C5Cl)N=N4)CC3)C2 COC(=O)C1=CN([C@H1]2CCCN(C(=O)N[C@@H1]3C[C@H1](F)CN3)C2)N=N1 C[C@@H1]1C(=O)N(CC(=O)NCC[C@@H1]2CCN(C(=O)CC#N)C2)C(=O)[C@@H1]1C CC[C@H1](C)[C@@H1](CNC(=O)[C@@H1](CN(C)C)NC(=O)CC1C[C@H1]2C[C@@H1]2C1)OC O=C(NCCN(C(=O)C1=C[C@H1]2C=C[C@@H1](C1)C2)C3CC3)C4CC=CC4 COC(=O)[C@H1]1CN(C(=O)NC[C@@H1]2CCN(C(=O)OC(C)(C)C)C2)C[C@@H1]1N(C)C CCC[C@H1](O)C(=O)N1C[C@H1]2CN(C(=O)C3=CC(N)=CC=C3[N+1](=O)[O-1])C[C@H1]2C1 CN1CCC(CC(=O)NCC[C@H1]2C[C@H1](NC(=O)C3=CC=CC(Br)=C3)C2)CC1 CC(F)(F)CCC(=O)N1CC[C@](C)(CNC(=O)C2=CC=C(C(N)=O)C=C2)C1 C[C@H1](C(=O)NC1=CC=CC(C(F)F)=C1)N2CCCC2=O CC=C(F)C(=O)N1[C@H1]2CC[C@H1]1CN(C(=O)C3=CC=4N=C(O)[NH1]C=4C=C3N)C2 C=C(C)CCC(=O)NC[C@H1]1CC[C@H1](C)N(C(=O)CCN2C=CN=C2C)C1 C=CC1=CC=C(C(=O)NC(C)(C)[C@@H1]2CCN(C(=O)C3=CC=C(N)C=C3)C2)C=C1 C=CC(C)(C)CC(=O)N[C@H1]1C[C@](F)(CNC(=O)[C@@H1]2C[C@H1]2C3=C(Cl)C=CC=C3Cl)C1 C#CCC(CC#C)C(=O)NC1CCN(C(=O)[C@H1](C)OCCCCCC)CC1 COCCCC(=O)NC[C@@H1]1CC[C@H1](NC(=O)CC2=CC=C3N=C[NH1]C3=C2)C1 O=C1C[C@@H1]2CCC[C@]2(C(=O)N3CCCC[C@H1](CNC(=O)C4(C(F)F)CC4)C3)C1 COC(=O)[C@@H1](NC(=O)C[C@H1]1CCC12CNC2)C3=CC=C(C(C)(C)C)C=C3 CC(C)N(CCNC(=O)[C@H1]1CCC[C@@H1]1CNC(=O)[C@@]2(O)C[C@H1]3CC[C@H1]2C3)C4CC4 CC[C@@H1](NC(N)=O)C(=O)NCCN(C)C(=O)C=1C=C(C2=CC=CC=C2O)ON=1 O=C(NC[C@@H1]1CN(C(=O)C2=CC=C(CO)C=C2)CCCO1)[C@@H1]3CCC4(CCC4)O3 COC(=O)[C@@H1]1C[C@H1]1C(=O)NC2CCC3(CC2)CN(C(=O)CC(=O)NC4CC4)C3 CC[C@H1](COC)C(=O)NCC1(NC(=O)[C@@H1](C)SC)CC1 C[C@H1](CNC(=O)C1=CC=C[NH1]1)OC2=CC=C(Cl)C=C2 C[C@@H1](CN(C)C(=O)CC1=CC=CN=C1N)NC(=O)C2=CN=C3N2[C@H1](C)CCC3 CCN1C=C(CNC(=O)[C@]23C[C@@H1]4C[C@@H1]2[C@H1]3[C@H1]4O)N=N1 CCN1N=CC(C)=C1NC(=O)[C@H1]2CCCN(CC3=CN=CC=N3)C2 CC(C)CC[C@@H1](F)C(=O)N1CCC[C@@H1]1CC(=O)N2CCC(CC(C)C)CC2 CC=1N=C(O)[NH1]C=1C(=O)N[C@@H1]2CCN(C(=O)[C@H1](O)C3=CC=C(C#N)C=C3)C[C@H1]2F COCC1=CC=C(C(=O)N[C@@H1]2C[C@H1]2NC(=O)C3C4CCC3CC4)C=C1F CO[C@]1(C(=O)N[C@@H1]2CCN(C(=O)C3=CC=C(CN=[N+1]=[N-1])O3)C[C@@H1]2F)CCSC1 C[C@H1](CN(C)C(=O)C1=C[NH1]N=C1CCNC(=O)C2CC(F)(F)C2)C(F)(F)F CCCC=1[NH1]C=CC=1C(=O)N[C@H1]2CCCCCC[C@H1]2NC(=O)C3=CC=CC=C3 C[C@H1](CCN(C)C(=O)C1(C(F)(F)F)CC1)NC(=O)C2=CC(F)=CC(C3CC3)=C2 NC1=CN=CC=C1C(=O)N[C@H1]2CCCN(C(=O)C3=CC=C4C(=C3)CCS4(=O)=O)C2 C#CC[C@H1](CC(=O)N[C@@H1](C)CC(C)C)NC(=O)CCCN1C=NC=N1 C[C@]1(CNC(=O)[C@H1]2CCC(=O)C2)CCN(C(=O)C3(C4=CC=C(F)C=N4)CC3)C1 C[C@]1(C(=O)NC[C@@H1]2CN(C(=O)C3=CC=NN3C4CC4)CC5(CCC5)O2)C[C@H1]1Br O=C1NCCCC[C@H1]1C(=O)N[C@H1](CN=C2C=C(Cl)N=C[NH1]2)C3=CC=C(F)C=C3F C[C@@H1](CN1CCCCC1)C(=O)N2CC[C@@H1](NC(=O)C3=CC(Cl)=C[NH1]3)C[C@@H1](O)C2 CC1=CC=CC([C@@H1](C)NC(=O)[C@@H1](CCC2CC2)NC(=O)CN3[NH1]C=NC3=N)=C1 C[C@@H1](SCCONC(=O)CCCCC1=C[NH1]C2=CC=CC=C12)C(=O)O CC[C@H1](C)[C@@H1](CO)NC(=O)[C@@H1]1CC[C@H1](NC(=O)C2=CN=C(Cl)S2)CO1 COC1(CNC(=O)C2CC3(C2)CC3(F)F)CCN(C(=O)[C@H1]4C=CCC4)CC1 COC1=CC=C([C@H1](CNC(=O)C(F)=C2CCCC2)NC(=O)C3=CC(Cl)=C[NH1]3)C=C1 CC[C@H1](CC(C)C)C(=O)N(C)C[C@H1]1CCCCN1C(=O)C2=CN=CN2C CC(C)(C)OC(=O)[C@@H1]1CC[C@@H1]1C(=O)N2CCCN(C(=O)CN3C[C@H1]4C[C@@H1]4C3)CC2 C[C@](O)(CNC(=O)[C@@]1(F)CCN(C(=O)C2(C3=CC=NO3)CC2)C1)C4CCCC4 CCOC1CCN(C=2[NH1]C(=NC3C[C@H1]4C[C@@H1]4C3)N=C5C=2C=NN5C)CC1 CCN(C[C@H1]1CCCCN1C(=O)/C(F)=C/CCF)C(=O)C23CCC(C2)C3 N#CCC(=O)N[C@@H1]1CS(=O)(=O)C[C@@H1]1NC(=O)C2(C3=C(Cl)C=CC=C3Cl)CCCC2 CC1=NC=C(C(=O)NC[C@]23C[C@H1]2CN(C(=O)C4=CC(C(F)F)=CC=C4Cl)C3)S1 CCCC1=NC=C(C(=O)N2C[C@@H1](N=C3N=C(OC)[NH1]C(OC)=N3)C[C@@H1]2C)S1 CSCCOCC(=O)N[C@H1]1C[C@H1](C)CN(C(=O)C2=CC=C3N=CN=CC3=C2)C1 C#CC1CC(NC(=O)[C@@H1](CNC(=O)[C@H1](CN(C)C)N(C)C)C(C)(C)C)C1 CC(C)[C@H1](C(=O)NC1CC=CC1)C2=CC=C(Cl)C=C2 CC1=NC(C(=O)N(C)[C@H1]2CCCCN(C(=O)[C@@]3(C)CC(C4CC4)=NO3)C2)=CN1C CN1C=NN=C1SCC(=O)N[C@](C)(CNC(=O)C2(C#N)CCSCC2)C3CC3 CC1=CC(C)=CC([C@@H1](C)C(=O)N(C)C2CN(C(=O)[C@@H1]3C4CCN3CC4)C2)=C1 CP(C)(=O)[C@@H1](O)C(=O)NC[C@H1](CO)NC(=O)C1=CC=C2N=C(C(F)F)[NH1]C2=C1 CN(CC1CN(C(=O)C2=C(F)C=CC=3OC=CC2=3)C1)C(=O)CC4(C)CC4 CC1=CC(Cl)=CC=C1C(=O)N2C[C@@H1]3C[C@H1]4C[C@H1]3[C@H1]2[C@H1]4NC(=O)C=5C=N[NH1]C=5 O=C(COC1=CC=C2C(=C1)CCCC2)OC[C@@H1]3CCCN3C(=O)C4=CC=CC=C4 CC1=NC(C#N)=CC(N2C[C@@H1](NC(=O)C=3N=C(Cl)SC=3C)CC[C@H1]2C)=N1 CCC=CC(=O)N1CC2(CCC2)C[C@H1]1CNC(=O)COCCOCC CN1[NH1]C(C(=O)NC[C@@H1]2C[C@H1]3CC[C@H1]2N(C(=O)C4=CC=5[NH1]C=CC=5S4)C3)=NC1=O CC1=C(C(=O)NC[C@@H1](O)CNC(=O)[C@H1]2CC[C@H1]2C=3N=C[NH1]N=3)N=NN1C CC[C@@H1](C)/C=C/C(=O)N1CC[C@H1](C(C)(C)NC(=O)C2=CC=C3N=CC=CC3=N2)C1 CC(C)(C)N1CC[C@H1]1C(=O)NC[C@@H1]2CC(C(=O)NCC3=CC=C(C#N)S3)=NO2 CC[C@@H1](C(=O)NCC1=CCN(C(=O)C2=CN=C(C)O2)CC1)N3N=CC=C3C CC(C)(C)OC(=O)N[C@]1(C(=O)NC[C@@H1](O)CNC(=O)CCCC(F)F)CCOC1 NC1=CC=C(C(=O)N[C@@H1]2C[C@H1]3CC[C@H1]2N(C(=O)C=CC4=COC=N4)C3)N=C1Cl C[C@H1](CCCCNC(=O)[C@@H1]1CNC(=O)C1)NC(=O)C=2C=NN3C=CN=CC=23 CC[C@H1](C)CC(=O)NC[C@@H1](NC(=O)C(F)(F)[C@H1](O)C1CC1)C2CCCCC2 O=C(NOCC(=O)N1CC[C@H1](C(F)(F)F)C1)C2=CC=CC=[N+1]2[O-1] CC[C@](C)(CO)C(=O)NCC[C@@H1]1CCCN(C(=O)C=2N=C[NH1]C3=NC=NC=23)CC1 O=C(N[C@@H1]1CN(C(=O)/C=C/C(F)(F)F)CC2(CCC2)C1)C3=CSC=4N=NSC3=4 CC1=NC(CC(=O)NC[C@H1]2C[C@H1](CNC(=O)CCCCC3CC3)CO2)=CS1 O=C(N[C@@H1]1CCCCN(C(=O)C2=CC=3C=CSC=3[NH1]2)CC1)C=4SC=NC=4Cl CC1=C(C(=O)NC[C@H1]2CN(C(=O)C3=CSN=C3Cl)C[C@@H1]2C)SCCO1 CC[C@@](O)(CCC(F)(F)F)CNC(=O)C1(C2=CC=C(OC)C=C2)CCC1 COC(=O)C1(C)CCN(CC2=CC(Cl)=CC(Cl)=C2C)CC1 NS(=O)(=O)[C@H1]1COCCN(C[C@H1]2[C@@H1]3COCCN3CC2)C1 CC1=CC(Cl)=CC=C1C(=O)N2C[C@H1](NS(=O)(=O)C3=CC=C(Br)C=C3F)C4(CC4)C2 CC(=O)N(C)[C@@H1](C)C(=O)NC1(CNC(=O)[C@H1](C)SC2=NN=NN2C3CC3)CCC1 CSCCC(=O)N1CC[C@H1](C)[C@H1](NC(=O)CCCSC(C)(C)C)C1 C=CCCC1(C(=O)N2CC[C@@](CF)(C(=O)N3CC[C@H1](OC)[C@@H1]3C)C2)CC1 CN(C)CC1=CC=C(C(=O)N[C@@]23CCN(C(=O)C4=CC=NC(S)=C4)C[C@@H1]2C3)O1 CC[C@@H1](CNC(=O)N1CC2(C[C@@H1](NC(=O)CCOC)CO2)C1)OC CON=CC(=O)N[C@@H1]1CN(C(=O)CC=2C=C(Cl)N(C)N=2)C3(CCC3)C1 CCN(C(=O)[C@H1]1CCN(C(=O)C2=CN=NC=C2NC)C[C@H1]1O)[C@H1](C)C(=O)NC CN(C(=O)[C@@H1](O)C1CCCC1)[C@H1]2CCCCN(C(=O)COC=3C=N[NH1]C=3)C2 CCOCCC(=O)N1CC[C@H1](N(CCO)C(=O)[C@H1]2C[C@H1]2OCC)C1 CCC1(C(=O)N[C@H1]2C[C@H1](OC)CN(C(=O)CN3CCC(O)CC3)C2)CC1 CC(=CC1CC1)C(=O)N[C@@H1]2CCC[C@@H1]2NC(=O)C3=CC=C4C(=C3)CCOC4 C=C(C)C[C@@H1](NC(C)=O)C(=O)NC1CCN(C(=O)C2=CN=C(N)C=N2)CC1 C=C(C)CC(=O)NC[C@H1](C)N(CC)C(=O)C1=CC(N2C=CC=C2)=CC=N1 C[C@H1](NC(=O)C1CCCC1)C(=O)NC[C@H1](O)CN(C)C(=O)C2=NC(Cl)=CS2 CC1=CC=NC2=NC(C(=O)NC[C@](C)(O)[C@@H1]3C[C@H1]4CC[C@H1]34)=NN12 C#CC[C@H1](O)C(=O)N1CC[C@@H1]1CNC(=O)C2=CC=NC(C(C)(C)C)=N2 O=S(=O)(C1=CC=C(Cl)S1)N2CC[C@H1]3CCC[C@]32CNC(=O)C4(CO)CC4 C[C@H1]1CCC=C1C(=O)NCC2=CC=C(CNC(=O)[C@@H1]3C[C@H1]3C=4C=CN(C)C=4)C=C2 O=C(CC[C@H1]1CC1(Cl)Cl)N[C@@H1]2CCS(=O)(=O)C23CN(C4=NN=CO4)C3 O=C(NC[C@H1]1C[C@@H1]2CC[C@H1](C1)N2C(=O)C3=CC(Br)=NO3)C4=CC=CO4 CC1=CC=C(O)C=C1C(=O)N2CC(C)(C)C[C@@H1]2CNC(=O)[C@@H1](F)C(C)(C)O C[C@@H1]1CCO[C@@H1]1CC(=O)N2CCCC[C@H1](CNC(=O)C3=CC=CC(O)=N3)C2 CN(C)C[C@@H1](NC(=O)[C@@H1](CC1CCC1)NC(=O)C=CC2=CC=NC=N2)C(C)(C)C CCC1=CC=CC=C1N(C)C(=O)C2CCC(NC(=O)[C@H1]3CCCC(=O)C3)CC2 CC[C@@H1]1CCCN1C(=O)C(=O)N2CCC(C3(O)CN(C(=O)CO)C3)CC2 COC(=O)C1CN(C(=O)[C@@H1]2CC[C@H1](C)N2CC3=CC=C4C=CC(Cl)=CC4=N3)C1 C[C@@H1](CN1C=NN=C1)N=C2[NH1]C(=NC(CF)CF)[NH1]C3=C2COCC3 CC1=CC=CC=2C=C(CNC(=O)N3C[C@H1](O)CC[C@@H1]3C)[NH1]C1=2 CCN(CCNC(=O)C1=CC=C(CS(C)(=O)=O)O1)C(=O)C[C@H1]2CCCN2C CCN(C(=O)CCCNC(=O)OC)[C@H1]1CCCN(C(=O)C2=CC=CC(C)=N2)C1 C[C@@H1]1CO[C@H1](C(=O)NC2(CF)CN(C(=O)C3CC4(C3)CC4(F)F)C2)C1 O=C(NCC[C@H1]1CC1(Cl)Cl)N[C@H1]2CCC3=C[NH1]N=C3C2 CNC1=NC=CC=C1C(=O)N[C@H1]2C=CC[C@H1](C(=O)N[C@@H1]3COC(C)(C)C3)C2 CC#CC[C@@H1](NC(=O)OC(C)(C)C)C(=O)NN1C=NC2=CC=CC=C2C1=O NC1=NON=C1C(=O)N2CCC(NC(=O)C3=CN=C(CC4CC4)N=C3O)CC2 CCC1(C#CC(=O)NC[C@H1](CCNC(=O)CCC(C)(C)F)OC)CC1 C[C@H1](O)[C@H1]1C[C@@H1]1C(=O)NCC2(O)CN(C(=O)[C@@H1]3C[C@H1]4C=C[C@@H1]3C45CC5)C2 CCOC1(CNC(=NCC2CCC2)NCC3(N4C=C(Br)C=N4)CC3)CCOCC1 CCC1CC(C(=O)N(C)CCOCCNC(=O)C2=NOC3=CC(F)=CC=C23)C1 CC(=O)N1CC[C@@](C)(C(=O)N2C[C@@](CCNC(=O)C3=CSN=C3Cl)CC[C@H1]2C)C1 CC=1ON=C(C(=O)NNC(=O)NCCCCN2CC3(CCOCC3)C2)C=1C O=C(O)C1=CC=C(C2=CN(C[C@H1]3CCN(C(=O)CCSC4CCCC4)C3)N=N2)O1 O=C(NCC1=CC=C(F)C=C1)[C@H1](C2=CC=NC(F)=C2)N3CCO[C@@H1]4C[C@@H1]43 O=C(NCC=1OC=CC=1C(=O)NC(C2CC2)C3CC3)C=4C=CN5C=CN=C5C=4 CC(C)[C@@H1](CNC(=O)C1(C(C)(F)F)CC1)NC(=O)C2=CC=NC3=NC=CN=C23 C[C@H1](O[C@H1]1CCOC1)C(=O)N2CC(O)([C@@H1](C)NC(=O)[C@H1]3C[C@@H1]3C4CCC4)C2 C=CCNC(=O)[C@H1](C1=CC(C(C)C)=NO1)N2CCC[C@@H1](C3(C(=O)OC)CC3)C2 CN(C[C@H1](O)CF)C(=O)[C@H1]1COCCN(C(=O)C[C@H1]2CCCC(=O)N2)C1 O=C(CCNC(=O)[C@@H1]1CCCSC1)N[C@H1]2C[C@@](C)(O)C2 CC1=NC([C@@H1]2CCCN(C(=O)[C@@H1]3C[C@@H1](C)CN3C(=O)C4=NC=CC=C4Cl)C2)=NO1 COC1=CC=C([C@H1](C)C(=O)N2CC[C@@H1]3CN(C(=O)CNC=O)C[C@@H1]32)C=C1F O=C(CCCC(F)(F)C(F)(F)F)NCCOC1CN(C(=O)C2=CCCCO2)C1 CC(C(=O)N[C@](C)(C(=O)N1C[C@@H1]2C[C@@H1]2[C@H1]3C[C@H1]31)C4CCC4)=C5CCCC5 COC(=O)C1=CSC(C(=O)N2CCC=C(CNC(=O)[C@@H1]3C[C@H1]3C4CCC4)C2)=C1 CCN1N=NC(C)=C1CNC(=O)CCCCN(C)C(=O)C[C@]23CCC[C@H1]2C3 O=C1CC[C@@H1](C(=O)N[C@H1]2CO[C@@H1]3[C@@H1](NC(=O)C4CC5(CSC5)C4)CO[C@H1]23)CCO1 CC1=CC=C(CC(=O)N2CC(F)(F)C[C@H1]2CCNC(=O)[C@@H1](C(C)C)N(C)C)C=C1 CN(CCCNC(=O)[C@H1]1CCOC1(C)C)C(=O)C2=NC3=CN=CC=C3S2 CC1=CC=2SC(C(=O)NCC[C@@H1](C)N(C)C(=O)C3=CC(C(F)F)=NC=N3)=CC=2S1 CCC[C@H1](C#N)C(=O)NCC1(CCNC(=O)C=2N=NN3C=2CCCC3)CC1 CN(C[C@H1]1CCCN(C(=O)C2=CC(Cl)=CN2C)C1)C(=O)C3=CC=NC(O)=C3 CC[C@H1]1CC[C@H1](C(=O)N2[C@H1]3CC[C@@H1]2C[C@H1](CNC(=O)CCC(C)(C)C)[C@H1]3F)CC1 CN(CCNC(=O)CC1(C(F)(F)F)CC1)C2CCN(C(=O)CO)CC2 CN(C)CC[C@H1](NC(=O)C(F)=CC1CC1)C(=O)N(C)C[C@@]2(C)CCCO2 O=C(NC[C@@H1](C1=CC=CC=C1Cl)N2CCCC2)C3=CC=C(OCF)C=C3 CC1=CSC(C2=CC=CC(NCC3=CC=CC4=C3OC5=CC=CC=C54)=N2)=C1 CC=1C=NSC=1C(=O)N2C[C@@H1](CNC(=O)[C@@H1](C(C)C)N3C=NN=C3)CC24CCC4 CC1=NC=CN=C1CN2CC[C@]3(CCC[C@@H1]3C(=O)N[C@@H1](C)C4(O)CC4)C2 CC1=NC(C2CN(C(=O)C=3C=C(CCNC(=O)C[C@]4(C)CCOC4)ON=3)C2)=N[NH1]1 C#CCOCCC(=O)N[C@@H1]1C[C@@]2(NC(=O)[C@@H1]3CC(F)(F)C3(F)F)CO[C@@H1]1C2 CN1N=CC=C1/C(F)=C/C(=O)N[C@H1]2C=CCN(C(=O)CC(F)(F)C(F)F)C2 C=CC(C(=O)NC[C@H1]1CN(C(=O)C=2C(C)=COC=2C)C[C@H1](C(F)(F)F)O1)PCCC O=C(NCC1(NC(=O)[C@H1]2CCNC2=O)CC1)C3=NC=C(Cl)C=C3O O=C(NCCSCC1=CN([C@@H1]2CCCNC2=O)N=N1)C3=CC=CC=4C=NSC3=4 CSC1=CC(C)=C(C(=O)NC[C@@H1](CO)NC(=O)[C@H1]2CCCN2C3CC3)O1 CCCCC[C@H1](CC)C(=O)N[C@H1](CC(=O)NCC(=O)NCCO)C(F)F CC1=NS(=O)(=O)NC(C)=C1CC(=O)N[C@H1]2CCCCN(C(=O)[C@@H1](C#N)C3CC3)C2 C=CC[C@@H1](C)C(=O)NC[C@](C)(O)CNC(=O)C=1SC2=NC=CC=C2C=1N CC[C@@H1]1CC[C@H1](C)N1S(=O)(=O)C2=CC=CC(N(C)CC3=CC=CC(Cl)=C3)=N2 C[C@H1](OC(=O)C1=COC2=C(F)C=C(F)C=C12)C(=O)[C@H1]3CCCN3C CC(C)(C)OC(=O)[C@@H1]1C[C@]1(C(=O)NCC2=NC3=NC=CC=C3O2)C(=O)OC(C)C CCOCC(=O)NCC[C@H1](C)CCNC(=O)CN1C=NC(Br)=C1 OC1(C[C@@H1](O)CN=C2[NH1]C=NC3C=C([N+1](=O)[O-1])C=C23)CCCCC1 C[C@H1]1OCC[C@H1]1C(=O)NCCN(CC2=C3C(=NN2C)CCCC3)C4CC4 CCN1CC[C@H1](CNC(=O)[C@@H1]2CCCN2NC(=O)C3(C)CCOCC3)C1 CSC(C)(C)C(=O)NC[C@](C)(NC(=O)[C@@H1]1CC12CCC2)C3CC3 CC1(NC(=O)C2=CC3=CC=C(Cl)C(F)=C3[NH1]2)CN(C(=O)C4=C[NH1]C=C4C5CC5)C1 CN(CC1(O)CCN(C(=O)CSC2=CC=CS2)CC1)C(=O)C3=NOC(C)(C)C3 CN(CC1(CNC(=O)C=CC=2C=N[NH1]C=2)CC1)C(=O)CCC3=CN=CN=C3O CC(=O)C=1C=C(C(=O)N(C)C[C@@H1]2CCN(C(=O)CCC3=CN=CS3)C2)OC=1C C[C@@H1]1C[C@H1]2CN(C(=O)[C@@H1]3C[C@H1](F)CN3C(=O)C4=CSC=N4)C[C@H1]12 COC1(CC(=O)N2[C@H1]3CCC[C@H1]2CC(NC(=O)C[C@@H1]4C[C@H1]5C[C@H1]5C4)C3)CCCC1 CC(=CC1=CC=C(Br)O1)C(=O)N(C)CCCCCNC(=O)C2=C[NH1]N=C2C CC1=C(C(=O)N2C[C@H1](CNC(=O)CC(F)(F)F)N3CC[C@H1]2C3)C=CN1CC4CC4 CO[C@H1]1C[C@@H1](NC(=O)C(=O)NCC2=CC=C(F)C=C2)CN(C(=O)C3=CC=CO3)C1 CCN1C=CC=C1C(=O)NC[C@@H1](C)CN=C2C=C(C)C([N+1](=O)[O-1])=C(C)[NH1]2 C[C@@H1](CNC(=O)C1([C@H1]2CCCO2)CC1)NC(=O)[C@H1]3CCN3C(=O)OC(C)(C)C C[C@@H1](CC(=O)N[C@H1]1CO[C@H1]2CN(C(=O)C3=C(C#N)C=NN3C)C[C@@H1]12)CC(C)(C)C CCOC(=O)NCCCN[C@@H1](C1=C(F)C=C(Br)C=C1Cl)C2=NN=NN2C(C)C CC1=NNC(=O)[C@@H1]1CCC(=O)N2CCCN(C(=O)C=CC3=CC=NC=N3)C[C@H1]2C CC(C)C1=CSC(C(=O)N2[C@H1]3CC[C@@H1]2C[C@H1](NC(=O)C4(O)CCOCC4)C3)=N1 CCC=1OC=C(C)C=1C(=O)N2CC(O)(C3(CNC(=O)[C@@H1]4CCC[C@@H1]4OC)CC3)C2 CC[C@@](C)(CNC(=O)C1(C)CC2(CCC2)C1)NC(=O)CCCCCS(N)(=O)=O C=C=C[C@@H1](C)C(=O)N(C)CC(C)(C)CNC(=O)CC[C@@H1]1NC(=O)NC1=O CC(C)C[C@@H1](O)CC(=O)N[C@@H1](C(=O)N[C@H1](C)C1=NN=NN1C)C2=CC=CS2 CCO[C@H1](C(=O)NCC[C@H1]1CN(C(=O)C=C(C)C(F)F)CCS1(=O)=O)C(C)C C[C@H1](NC(=O)C1=CC=C(F)C=C1)C(=O)N(CC(N)=O)CC2=CC=CC=C2 CC[C@@H1](C(=O)N1CC[C@H1](C)[C@H1](NC(=O)C=2SC(C3CC3)=NC=2C)C1)N4C=CN=C4 CC1=CC=C(C=CC(=O)N2CC[C@@H1](C3=CN(CC(F)(F)F)N=N3)C2)C=N1 CC1(C)C(=O)NC[C@H1]1NC(=O)[C@@H1]2CCN(C(=O)CCC[C@@H1]3CCCO3)O2 CC=CC=CC(=O)N[C@@]12CCCN(C(=O)CCOC3=CC=C(F)C=C3)C[C@H1]1C2 CC(C)CN1C=C(CNC[C@@]23C[C@@H1]2CN(C(=O)[C@@H1]4CCC5=CC=CC(Cl)=C54)C3)C=N1 CC[C@H1](C)N1N=CC=C1C(=O)NCCC(C)(C)NC(=O)C2=CC=C(N)C=N2 CC(C)(CCC(=O)N1CC(NC(=O)CN2CC(=O)NC3=CC=CC=C32)C1)[N+1](=O)[O-1] CCCN(CCC)C(=O)[C@H1]1CCCN(C(=O)C2=CC=CN2C)[C@H1]1CC CC1(NC(=O)[C@H1]2CCCC[C@@H1]2NC(=O)C=3C=NN4C=CC=NC=34)CC1 O=C(NC[C@]1(F)CCN(C(=O)C=2N=COC=2C3CC3)C1)C=4C=CC5=CN=CN5C=4 COC(OC)[C@@H1](NC(=O)N[C@@H1]C1[C@@H1](C)OC2=CC=CC=C2[C@@H1]1C)C(C)C CC1(C)SCC[C@@H1]1CNS(=O)(=O)C2=CN=C(N3CCO[C@@H1](C(F)(F)F)C3)C=C2Cl COC(=O)C1=N[NH1]C2=CC(NC(=O)N3CC4CC3([C@@H1](O)C5=CC=CC=C5)C4)=CC=C12 CC1(C)CCC=2OC(C(=O)NCC3(O)CN(C(=O)[C@]4(CF)CC4(F)F)C3)=CC=2C1 CC1=CC(OCC(=O)N2CCC(C)(NC(=O)C3=CN(C4COC4)N=N3)CC2)=NO1 CCC(=O)C1=CC=C(C(=O)N2CCCN(C(=O)CCOC(C)C)C[C@H1]2C)C=C1 CN(C)C(=O)C[C@@]1(O)CCCN(C(=O)N(C)C2=CC=CC=C2)C1 CCN1C=CN=C1C(=O)N2CC(OCC(=O)N(C)C3(C=4C=C[NH1]N=4)CC3)C2 CC(C)(C)[C@H1](CO)C(=O)N1CC[C@@H1](CCNC(=O)C2=CC=CC3=C2CCCC3)C1 CC1=NC2=C(C(=O)NC[C@@H1](C)N(C)C(=O)C=3C=NN(CCO)C=3N)C=CC=C2O1 CC(C)(C)OCCCCN=C(NC[C@H1]1CNC(=O)C1(F)F)NC2CC2 CN1C=C(CCNC(=O)[C@@H1]2CC[C@H1](O)CN2C(=O)CCCCC#N)C=N1 CC[C@@H1](NC(=O)C1=NC=CN=C1NC)C2=CN=C3C=CC=CC3=C2 C#CCCCCCCNC(=O)C[C@@H1]1COCCN1C(=O)C2=CN=CC(C#C)=C2 CCC1=C(C(=O)N2CC(C)(NC(=O)C3=CN=C(Cl)S3)C2)C=NN1C4CCCC4 COC1=CN=CC(CNC(=O)[C@@H1]2CN(C(=O)C3CCS(=O)CC3)C[C@H1]2C)=C1 O=C(CN1N=CC=CC1=O)N2CCC3(C2)CN(C(=O)[C@]45CCC[C@H1]4CC5)C3 O=C(N[C@H1]1CN(C(=O)[C@H1](F)C2CCCC2)C3(CCC3)C1)C4CC5(C4)CC56CC6 O=C(NC1(CO)CN(C(=O)C2=CC(O)=C(O)C(O)=C2)C1)C3=CC(O)=CC=C3I O=C(O)C1(C2=CC=C(Br)C=C2)CCN(CC=3C=CC4=NON=C4C=3)CC1 CCC[C@H1](C)C(=O)N[C@]1(CO)CCCN(C(=O)[C@@H1](SC)C(C)C)C1 CC[C@@H1](CC(=O)NCCCC1CCC1)N(C)C(=O)C2=CC[C@@H1](C)CC2 CC[C@H1](CNC(=O)OC(C)(C)C)CC(=O)N1CC[C@H1]1CNC(=O)CC=2C=CSC=2 C#CC[C@@H1](CC)NC(=O)/C=C/CC(C)(C)NC(=O)[C@H1]1CCCN1CCC C=CCNC(=O)[C@H1](C1=CC=CC(Cl)=C1Cl)N2CC3=N[NH1]C=C3[C@@H1]2C(=O)OC C[C@H1]1C(=O)NC2=CC(C(=O)N3C[C@H1]4CC[C@H1]3[C@H1](N)CC4)=CC=C2N1C C=CCOC[C@@]1(C(=O)OCC2CS(=O)(=O)CC2)CCN(C(=O)OC(C)(C)C)C1 CCC1=NOC(CCCC(=O)NC2C(NC(=O)C3=CC=4SC=CC=4S3)CCC2C)=N1 CCC(C)=C(C)C(=O)N1CCN(C(=O)C2=CC3=C(O2)CCCC3)[C@@H1]4C[C@H1]41 C[C@@H1](CCNC(=O)C1=CC(O)=CS1)NC(=O)CC=2C=CN(CC(F)(F)F)N=2 FC(F)(F)C(F)(F)[C@@H1](CNC1C=NO[C@H1]1C2=CC=NC=C2)C3=CC=CC=C3 CC(=O)NC1(C(=O)N(C)CCCCCC(=O)N(C)[C@@H1]2CCC[C@H1]2C#N)CCC1 CC=CCCC(=O)N(CC)[C@H1](C)C(=O)NCCOCC(F)F CCCN1C(C(=O)N[C@@H1]2CN(C(=O)C(C)(C)F)CC[C@H1]2O)=CC3=CC=CC=C31 CC(Cl)=CC(=O)NC[C@@]1(C)CCCN(C(=O)C2=C[C@@H1]3CCCCC[C@H1]23)C1 COCCCCN(C)CCC(=O)N1C[C@H1]2C[C@@H1](NC(=O)C3=CC=C(Cl)O3)[C@H1]1C2 C#CCCC[C@@H1](C)C(=O)N1CC[C@H1](CNC(=O)C=2C=NN(C)C=2N)C1 CCCC1=CC(C(=O)N[C@H1](CCSC)C(=O)N2C[C@H1](CO)C(C)(C)C2)=NO1 C[C@H1](OC(=O)C1=CC=CC(C(=O)C2=CC=CC=C2)=C1)[C@@H1](C)N3C=CC=N3 CCC1(C#CC(=O)NC[C@H1](NC(=O)CC2=NC(C)=C(C)S2)C3CC3)COC1 CCN(C)CC(=O)N(C)C1CC(NC(=O)C(=O)C2=C(C)[NH1]C3=CC=CC=C23)C1 N#CC1=CC(C(=O)N[C@@]2(CNC(=O)[C@H1]3CCC4(CCC4)CO3)CCOC2)=C[NH1]1 CC(C)(C)C#CC(=O)N[C@@H1](CC1CC1)C(=O)N2CC=C[C@@]2(C)CO CCCNC(=O)[C@H1](C1CCOCC1)N2C[C@H1]3[C@H1](C2)C3(C)C N[C@H1]1CCN(CCCNS(=O)(=O)C2=CC=C(NC3C[C@@H1]4CC[C@H1](C3)O4)N=C2)C1 COCC[C@@H1](CNC(=O)[C@@H1]1C[C@@H1]2C[C@H1]1CO2)NC(=O)COC=3C=CSN=3 O=C(NC1=CN=CC(F)=C1Cl)[C@H1]2CC23CCN(CC4=CC=C(Br)C(Cl)=C4)CC3 CC(C)COCC(=O)N1CC2(CCN(C(=O)C3=CN=C4N=CC=CC4=C3)CC2)C1 CC(=CC(=O)N[C@@]1(C(=O)NCC2=C(C)CCC2)CCC(C)(C)C1)C3=CC=CO3 CN(C(=O)[C@@H1]1CCC2(CCC2)CO1)C3CCC(NC(=O)CC4=CC=CS4)CC3 CC1=NN=C(C(=O)NC[C@@]2(NC(=O)C=3C=C4N(N=3)CCC[C@@H1]4O)CCOC2)S1 O=C(NCC1(NC(=O)[C@@H1]2CC23CCOCC3)CC1)C4=N[NH1]C=C4Cl CC[C@H1](C)NC(=O)[C@H1]([C@@H1]1CC12CCC2)N3CCC[C@@H1](C4=NN=CN4C)C3 CN=C1[NH1]N=C(CC(=O)NC[C@](C)(NC(=O)C2=CC(OC)=NO2)C(C)C)S1 CO[C@@H1](C)C1=NC(C(=O)NC[C@H1]2CC3(CC3)CN2C(=O)C=CC=4C=C[NH1]C=4)=CO1 CC[C@H1](C(=O)NC[C@@H1](O)CCNC(=O)C1=CN=C(C)C=C1C)N2N=CC=C2C CC1=NC=C(NC(=O)[C@@H1](CNC(=O)C2CN(C3CCC3)C2)CC4CC4)C=C1C#N COC1=CC=C([C@@H1](O)C(=O)NCCCCCCNC(=O)COCC(C)(C)C)C=C1 CC1=CC=CC=C1N2N=C(C(=O)N[C@@H1](C)[C@H1](C)NC(=O)C(C)(C)C#N)C=C2C CC(C)(C(=O)N1C[C@@H1]2[C@H1](C1)[C@@H1]2NC(=O)CCN3C=NC=N3)C4=CC=CC=C4 C[C@]1(CNC(=O)C#CC2CCOCC2)CCN(C(=O)C(=O)NC3CC3)C1 CC1=CC=C(N)C=C1C(=O)N[C@@H1]2C[C@@H1]3CC[C@@]2(NC(=O)CCCC(C)C)C3 COC(=O)C1CN(C(=O)C[C@H1]2CCCN(S(=O)(=O)C(C)C)C2)C1 CC(C)CSCCNC(=O)[C@H1]1CCN(C(=O)CCCOC(C)(C)C)C1 C=CC=1C=NN(C)C=1C(=O)N2C[C@@]3(NC(=O)C4=CC5=CC=CC=C5S4)CC[C@H1]2C3 O=C(C[C@H1]1CC[C@@H1](O)C1)NC2CC3(C2)CN(C(=O)C4=CC5=CC(Cl)=CC=C5S4)C3 CCN1C=NN=C1C(=O)NC[C@@]23CC[C@@H1](C2)N(C(=O)[C@@](C)(CC)OC)C3 COC1=CC=C([C@@H1](NC(=O)C(=O)NCC2(OC)CCCCC2)C(C)C)C=C1 CC1=CC=C(C(=O)NCC2(CNC(=O)C=CC=3C(C)=COC=3C)CCOCC2)S1 O=C(CCC1=CC=CC=N1)N2C[C@H1]3CCC[C@@](NC(=O)C=CC4=COC=N4)(C3)C2 CC1CC2(C1)CC(C(=O)N[C@H1](C(=O)NCCN(C)CCF)C3(O)CCCCC3)C2 C[C@@H1](CNC(=O)C=1C=CSC=1Cl)N(C)C(=O)C[C@@H1](C)CC2=CC=CC=C2 CC[C@@H1]1C[C@@H1]1C(=O)N2CC[C@H1]3CC[C@@H1](C2)N3C(=O)[C@@H1]4CC(=O)N4 COC1=NC=C(C(=O)N2CCN(C(=O)[C@@H1]3[C@H1]4CC(F)(F)C[C@H1]43)CC2)C=N1 C[C@@]1(CNC(=O)C2=CC=CC3=C2CCC3=O)CCCN1C(=O)C4=NN=C(S)N4C CC1=CC(F)=C(C(=O)N2CC(CNC(=O)C[C@@H1](C)N(C)C)(C(N)=O)C2)C(F)=C1 CCOC1=C(F)C=CC=C1C(=O)NCC2(F)CN(C(=O)[C@H1]3CCCNC3=O)C2 CCCN(C(=O)C=1C=C(C(F)F)[NH1]N=1)[C@@H1](C)C(=O)N(CCO)CC(F)F CC(=O)NCCC(=O)N(C)C[C@H1]1[C@@H1]2CN(C(=O)[C@H1]3C[C@H1](N(C)C)C3)C[C@H1]12 CSC1=CC(C2=NC(C=3C(C)=NOC=3C)=NO2)=CC=C1N CC1=NC(C2CCOCC2)=NC=C1C(=O)N[C@@H1](C)CNC(=O)[C@H1]3CCC(=O)[C@H1]3C CC=1C=C(C2=CN([C@H1]3CCN(C(=O)C=4N=C[NH1]N=4)C3)N=N2)SC=1C CC1=C(C(=O)N2CCC[C@]3(C2)[C@@H1](NC(=O)CC4=CC=NO4)CCN3C)N=NN1C CCCC[C@H1](C)N(C)C(=O)C1(NC(=O)C[C@@H1]2C[C@H1]3C[C@H1]3C2)CC1 CCN(C(=O)[C@@H1]1C[C@H1]2C=C[C@@H1]1C2)[C@@H1]3CCN(C(=O)CCCC4=NC=C(Br)C=N4)C3 CC(C)[C@@H1](O)C(=O)N1CC(F)(F)C[C@]1(C)CNC(=O)[C@H1](C)SC2=CC=CC=C2 CC(=O)N1C[C@@H1]2[C@H1](C1)CN2C(=O)C[C@@H1]3CCN(C(=O)OC(C)(C)C)C3(C)C C=CCCOCCNC(=O)CNC(=O)CNC(=O)[C@@H1](C)CC1CCC1 CCCCC[C@@H1](CC)C(=O)N1CCC2=CC=CC=C2[C@@H1]1CNC(=O)C(F)=C(C)C CC1=NN(C)C(C)=C1NC(=O)C2=CC3(CN(C(=O)[C@H1]4CCCS[C@H1]4C)C3)OC2 COCC1=CC=C(C(=O)N2CCN(CC(=O)NCC(=O)N(C)C)C[C@@H1]2C)C=C1 COCC(=O)N1CC[C@@H1](C(=O)N[C@H1]2C[C@@H1](OC)C2)C13CCC3 CC(=O)OCC1CN(C(=O)C2=C(C3CCOCC3)OC=N2)C1 COCC[C@H1](NC[C@@H1]1CCSC1)C2=CC=C(Br)C=C2 C#CCO[C@H1](C)C(=O)NC1CC2(C1)CC(C(=O)N3C[C@H1](C)O[C@@H1](CC)C3)C2 C[C@@H1]1C[C@H1]2CN(C(=O)[C@H1]3C[C@H1]3CN(C)C)C[C@H1]2N1C(=O)C4=CC5=CC=CC=C5[NH1]4 COC1(CC(=O)NC[C@H1]2C[C@](F)(CNC(=O)CCCNC(=O)C(C)(C)C)C2)CC1 CCC=1ON=C(C)C=1COC(=O)C=2C(C)=NN([C@@H1]3CCS(=O)(=O)C3)C=2C CC[C@@H1](C(=O)NC[C@@]1(C)COCCN(C(=O)CSC)C1)N(C)C CC(C)[C@@H1](CCNC(=O)C1=CN=C2SC=CN12)N=C3[NH1]C=CN=C3F CN1CCOC[C@@H1](NC(=O)[C@](C)(CO)NC(=O)[C@H1](O)CC(F)(F)F)C1 CC1=NC=CC=C1CC(=O)N2CCC(C(C)(C)NC(=O)[C@H1]3CN(C)C[C@H1]3C)CC2 C=C=CCC(=O)N1CCC[C@]2(CC[C@H1](NC(=O)C3=CC=C4C(=C3)OCC4)C2)C1 O=C(CC[C@H1]1CCOC1)N[C@H1]2CCN(C(=O)CC3CCS(=O)(=O)CC3)C24CC4 CON=CC(=O)N1CCC[C@H1](C2CN(C(=O)[C@@H1]3C[C@H1]3C4=CC=C(OC)C=C4)C2)C1 CCN(C(=O)COCCF)[C@H1]1CCCN(C(=O)C2=CC3=CC=CC=C3N=N2)C1 O=C(C=CCN1CCCC1)N2C[C@@H1]3CC[C@H1](C2)N3C(=O)CCC=4C=COC=4 CON(C)C1CN(C(=O)[C@@H1](CNC(=O)[C@]2(C)COC(=O)N2)N(C)C)C1 CC1=CN=C(C(=O)NCC[C@@H1](C)N(C)C(=O)C2=CC=C(C(C)C)C(Cl)=C2)C=C1C C[C@@H1]1CN(C(=O)C2=NC=CC=C2F)CCN1C(=O)CC3CCC(C(F)(F)F)CC3 C#CC[C@@H1](C(=O)N1CC[C@@H1](C)C[C@H1]1CNC(=O)C=2C(Cl)=NOC=2C)C3CC3 CO[C@@H1]1CC[C@@H1](C)N([C@@H1](CC[C@H1]2C[C@H1]2C)C(=O)NCC3=CC=CC=C3)C1 CC(C)(C(=O)NC[C@@H1]1CCN1C(=O)C2=CN=C3C=CC=NC3=C2)C4=NC=CO4 CC1=CC(C)=CC(C2(C(=O)N[C@H1]3C[C@H1](CNC(=O)[C@@]4(Cl)CC4(C)C)C3)CC2)=C1 CC(C)CC(=O)NCC1CCC(C(=O)NC2=CC=C(C#N)C=C2O)CC1 CC[C@](C)(C(N)=O)C(=O)N[C@@H1](C)CCCCNC(=O)C1=CN=C(C)N=C1OC CC1=NN=C(CC(=O)N[C@H1]2C[C@H1](NC(=O)C3=N[NH1]C(C)=C3Cl)C24CCC4)O1 C[C@@H1](NC(=O)[C@@H1]1CN(C)CCN1C(=O)C=CC2=CN=CS2)C(C)(C)CO CN1C[C@@H1](C(=O)N2CCCC[C@H1](C3CN(C(=O)C4=CC=C(Cl)O4)C3)C2)CCC1=O CSC1=NC=CC(N2CCO[C@H1](CN(C)C(=O)CC=3N=C4N=CC=CN4N=3)C2)=N1 COC1(CNC(=O)[C@H1]2CN(C)CCO2)CCC1 CC1=NC(C=CC(=O)N[C@]23CCCN(C(=O)[C@]4(C)C[C@@H1](C#N)C4)C[C@H1]2C3)=CS1 CCOCCCCCC(=O)N1CC([C@@H1](OC)C(=O)NCC2(OC)CC2)C1 C=CCCN1C=C(C(=O)NS(=O)(=O)C=CC=C(C=O)OC)N=N1 CC[C@@H1](CCOC)N=C1[NH1]C(=NCC2=CC=C(Br)C=C2C)[NH1]C3=C1COC3 CC(C)[C@H1](CCN(C)C(=O)[C@@H1]1C[C@H1](C)CO1)NC(=O)C(C)(C)C(F)(F)F CCCOCC(=O)N(CCCN(C)C)CCNC(=O)C1=NOC2=NC=CC=C12 CN1C=CN=C1C(=O)N[C@@H1]2CCN(C(=O)[C@@H1](CC#N)C3=CC=CC=C3)C2 C#CCOC1=CC=C(C(=O)N2C[C@@H1](CNC(=O)/C(C)=C/C)C3(CC3)C2)C=C1 O=C(NCC1CC1)C(=O)N[C@H1]2C[C@]23CCN(C(=O)C4CC5(CC(F)C5)C4)C3 CCC=1N=C(Cl)[NH1]C(=NC[C@H1]2CN(C(=O)[C@@H1](C)C3=CC=C(C)S3)CC2(C)C)C=1Cl CC1=CC(O)=CC(C)=C1C(=O)N[C@H1](CNC(=O)C2CC=CC2)[C@@H1]3CCOC3 CCCC1=CC(C(=O)N2CCC[C@H1](NC(=O)[C@@H1]3CCC4=NN=NN4C3)[C@@H1]2C)=NO1 CS(=O)(=O)CCCNC(=O)[C@H1]1CC=CCN1C(=O)C=CC=2C=C[NH1]C=2 CCN1N=C(C)C(C(=O)N[C@H1]2CCC[C@H1](NC(=O)CCCN3C=CN=C3C)C2)=N1 COC(=O)[C@H1](OC)C(=O)N1CC(CO)(NC(=O)CN(C)C2CCC2)C1 CC1=CC(C(=O)NC[C@]2(O)CCCN(C(=O)COC3CCCCC3)C2)=CS1 CC[C@H1](C(=O)NCC12CC(NC(=O)C3=CC=CN=C3O)(C1)C(C)(C)O2)C(C)C C[C@H1](C(=O)NC=1C=NN(C)C=1)C2CCN(CC=3C=NN(C4=CC=CC=C4)C=3)CC2 C[C@H1]1CNC2=C(CNC(=O)[C@]3(C)CCCN(C(=O)[C@@](C)(Cl)CCl)C3)C=NN2C1 COC1=CC(CCC(=O)NCCCOCCN(C)C(=O)C23CC(C)(C2)C3)=CC=N1 C[C@@H1](CNS(=O)(=O)C1=CC=C(N(C)CCCCC2=CC=CC(Br)=C2)N=C1)C(F)F O=C(NC[C@H1]1CCN(C(=O)[C@@H1]2OCCC3=CC=CC=C32)C1)[C@H1]4CCS(=O)(=O)C4 CC[C@@H1]1[C@H1](NC(=O)[C@H1]2CC[C@H1](F)C2)CCCN1C(=O)[C@@H1]3CCC[C@H1](C)CC3 N=C1N=C[NH1]N1CC(=O)NN2CCC[C@H1]2C(=O)NCCN3CCCCC3 CN(C)CC[C@H1](O)C(=O)N1C[C@H1]2C[C@]2(CNC(=O)C3=CC=NC4=C3N=NN4C)C1 CO[C@@H1]1C[C@H1](CNC(=O)C2=C(C)CCCC2)N(C(=O)[C@@H1](C)NC(=O)C(C)(C)C)C1 COCC[C@H1](CNC(=O)CCCN=[N+1]=[N-1])NC(=O)C1=CC(C(F)(F)F)=C[NH1]1 O=C(C[C@@H1]1CC2(CC2)CN1C(=O)[C@]34C[C@H1]3CNC4=O)NCCCOC5CCC5 CSC=CC(=O)NC[C@@H1]1CC2(CCN(C(=O)[C@@H1]3CCCN3C=O)CC2)CO1 CCCCSCC(=O)N1CCSC[C@H1]1CCNC(=O)C2=CC(Cl)=CC(OC)=C2 CC(=CC1CCCC1)C(=O)NC[C@H1]2CCCN(C(=O)[C@H1]3CC=C(C(C)C)CC3)C2 COCCC[C@H1](NC(=O)[C@H1](C)OC1=CC=CC(Cl)=C1)C(=O)N2CCCC2 COC(=O)[C@H1]1C[C@@H1]1C(=O)NCC[C@@H1]2CCN(C(=O)C3=C[NH1]C=C(F)C3=O)C2 CCN1N=C(C(=O)NC[C@@H1]2[C@H1](C)CCCN2C(=O)COCCCOC)C=CC1=O CCC1=CC(C(=O)N[C@H1](C)[C@H1](C)NC(=O)C2=C(Cl)C(CC)=NN2C)=C(C)O1 CC[C@@H1]1C[C@H1]1C(=O)N(C)C[C@H1](O)CN(C)C(=O)C2=N[NH1]C3=C2CC(F)(F)CC3 C[C@@H1]1C[C@@H1](NC(=O)C2(S(N)(=O)=O)CC2)CCN1C(=O)CCC(=O)C3=CC=CC=C3 C=C=CCCC(=O)N1C[C@@H1](NC(=O)C2=C(C)N=C(C)N=C2C)CC(C)(C)C1 CC[C@H1]1CN(C(=O)[C@H1]2CCCCN2S(=O)(=O)CCOC)CCN1C(=O)CO CC1=NC(N[C@@H1](C)C2=CC=C(CNC(=O)CN=C3C=C[NH1]C=C3)C=C2)=NC=C1Br O=C(C1=NOC=C1Cl)N2C[C@H1](C3=CN(CC[C@@H1]4CC4(Cl)Cl)N=N3)CC25CCC5 CN(CCOCCCN(C)C(=O)CC1=NC([N+1](=O)[O-1])=N[NH1]1)C(=O)C[C@@H1]2CCOC2 N=C1C=CC(C(=O)N[C@H1]2C[C@@H1](O)CN(C(=O)CN3C=C(Cl)C=N3)C2)=C[NH1]1 CSC=1C=NN(C)C=1C(=O)NCCCCNC(=O)C2=CC=C(O)N=C2 CC1=CC(C(=O)NCC[C@@]2(O)CCCN(C(=O)[C@]3(O)CCOC3)C2)=CN(C)C1=O CSCC(=O)N1CCOC[C@H1](CNC(=O)CSC2=CC=CC(C)=C2)C1 C[C@@H1]1CCCC[C@@H1]1C(=O)N(C)C[C@@H1]2CN(C(=O)C3=CC=CC4=NON=C34)CCO2 C[C@@H1](C(=O)N1CC(C)(C(=O)N2CC[C@H1](C(F)(F)F)C2)C1)N3C=NC=N3 CCC[C@](C)(O)CC(=O)N(C)[C@@H1]1CCN(C(=O)C[C@H1](C)C2CC2)C1 O=C(NCCO[C@H1]1CCN(C(=O)[C@H1](O)C2=CC=CC=C2Cl)C1)C3=CC=NC=C3Cl CC/C(C)=C/C(=O)N1CC[C@H1](C)[C@@H1](CNC(=O)C2=CC3=CN=CC(C)=C3S2)C1 O=C(NC[C@]1(NC(=O)C2C[C@H1]3CC[C@H1](C2)C3)CCOC1)C4=C5CCN=C5NC=C4 C#CC1=CC=C(C(=O)NC2CCC(C(=O)N(CC)[C@H1](C)COC)CC2)C(F)=C1 CC1=CN=C(C(=O)N[C@H1](C)CCCCNC(=O)[C@@H1](O)C2=CC=C(Cl)C=C2)C(O)=C1 CCC(=O)C1=CC=C(OCC(=O)N(C)C(=O)[C@@H1]2CCNC(=O)C2)C=C1 CC1=CC=CC=C1/C=C/C(=O)NC[C@]23CCCC[C@H1]2CN(C(=O)OC(C)(C)C)C3 O=C(OCC1=CC=CC(N2C=NN=N2)=C1)[C@@H1]3CCN(CCO)C(=O)C3 CN(C)CC1=CC(C(=O)N(C)[C@@H1]2CN(C(=O)C3(F)CCCC3)CC24CC4)=NO1 CCCC[C@@H1](O)CC(=O)NC[C@H1]1C[C@H1](NC(=O)C2=CC(C)=C(C)C=C2C)C[C@H1]1O CC(C)C[C@H1](NC1=NC=NC2=CC(Br)=CC=C12)C(=O)N3CCN(C)CC3 CCOC(=O)CCNC(=O)[C@H1]([C@@H1]1[C@H1]2CCCC[C@H1]21)N3CC[C@@H1](C(=O)OC)C[C@H1]3C COC1(CCNC(=O)[C@@H1](CC2CCCC2)NC(=O)CC[C@H1]3CCCOC3)CCC1 CC1=C(Cl)C=CC=C1C(=O)N[C@H1](C)[C@H1]2CN(C(=O)C3=NN=C(O)C=C3O)CCO2 CCOC(=O)C1(N(CC)CC2=CC=CC(OCC)=N2)CCCC1 C[C@@H1](CN(C)C(=O)[C@@]12C[C@@H1](CO1)N(C(=O)CCC3=CC=NC=C3)C2)C(C)(C)C CCN1N=CC(C(=O)N[C@@]23CC[C@@](CNC(=O)C4=NC=CC=C4N)(C2)OC3)=C1C CC1=CC=C(C(=O)N[C@@](C)(CNC(=O)C2CC2)C3CC3)N=N1 CCC=1SC([C@@H1](C)N=C2[NH1]C(=N[C@H1](C)CCSC)C3=CC=CC(F)=C3[NH1]2)=CC=1C CC1=CC=CC2=C1O[C@H1](C(=O)N[C@H1]3C[C@H1](CN4C=NC=N4)C3)C2 CC(=O)NC[C@@]1(C(C)(C)C)CCN(C(=O)C=2C=NN(C3=NC=CS3)C=2)C1 CCC[C@@H1](C)CCNC(=O)[C@H1](COC(C)C)NC(=O)[C@@H1]1C[C@H1]1CC(C)C CC1=CC=C(C(=O)N2C[C@@H1]3CCC[C@]3(N=C4[NH1]N=CO4)C2)C(Cl)=C1 C=C(C)CC(=O)N(C)CCN(C)C(=O)C(COCC)CC(C)C C=C1CC(CNC(=O)C=2C=COC=2C)(C(=O)N3CCC(F)(F)[C@H1](F)C3)C1 C[C@@H1]1CC[C@@H1]1C(=O)N[C@H1](C)CNC(=O)C2(CCC3=CC=CC=C3)CCCC2 O=C(NC1(C2=CC=CC=N2)CC1)C(=O)N[C@H1]3C[C@@H1](C4=CC=CC=C4)C3 C[C@H1]1CO[C@H1](CS(=O)(=O)N2CCN(C(=O)C3=CC=CN=N3)CC2)C1 C=C(C)C[C@@H1](OC)C(=O)N[C@H1]1CN(C(=O)CCN2N=C(C)N=C2C)C[C@@H1]1C3CC3 O=C(C[C@H1]1CC=CCC1)N2CCC(N(CCO)C(=O)[C@@H1](F)CC3CCC3)CC2 CC1=NC(=NCC2(CNC(=O)COC3(C)CCC3)CCCCC2)S[NH1]1 CC(C)(O)C#CC(=O)N1CCC[C@H1]1CNC(=O)[C@H1](O)C2=CC=CC=C2Cl C#CCCCOCC(=O)N1CCSC[C@H1]1CCNC(=O)CCC(=O)NCCC CN(CC[C@@H1]1CCCO1)C2=NN=C([C@@H1](F)CC3CCC3)N2CCC4=CC=CC=C4 CC1=CN=C(C(=O)N[C@@H1]2C[C@@H1](CC(=O)N3C[C@H1](C)[C@@H1](CO)C3)C2(C)C)C=N1 CC1=CSC(CCNC(=O)[C@](C)(C2CC2)N(C)C(=O)CC3=CC=C[NH1]3)=N1 O=C(NC1=CC=C2C(=C1)CCC2)[C@H1](O)C3CCS(=O)(=O)CC3 CN(C(=O)[C@H1]1CCCN(CC2=CC=3C=COC=3C=N2)C1)C4=CC=CC=C4 C[C@@H1]1CN(C(=NCCC2=CC=C(S(N)(=O)=O)C=C2)NC3CC3)CC[C@H1]1C CO[C@H1]1COC[C@@H1]1N2C=C(CONC(=O)C3=C(C)C=C(Cl)C=C3C)N=N2 C#CC12CC(CN1CC(=O)[C@@H1](C)OC(=O)C=3OC(C)=NC=3C)C2 C=C(C)CN1N=NN=C1[C@H1](N[C@H1]2C[C@@H1](C3=NN=C(C)O3)C2)C=4C=NN(CCC)C=4 CC1=CC=CC=C1C(=O)NCC2=CC=CC=C2CNC(=O)C=3OC=CC=3C CC(=O)NCCCC(=O)N1[C@H1]2CC[C@H1]1CC(N(C)C(=O)C=CC3=CN=CC=N3)C2 CCC1=CC(F)=C(C(=O)NCCCNC(=O)CC=2C=CSN=2)C(F)=C1 CCN(CC)CCC(=O)N1CC2(C[C@H1](NC(=O)CC[C@@H1]3CCOC3)CO2)C1 CC[C@@H1]1C[C@@H1](CC(=O)N(C)CC2CN(C(=O)C34CCCC3CCC4)C2)CCO1 CC(=O)N(C)CC(=O)N1CC[C@H1](OCC(=O)N2CC[C@@H1]2C3=CC=CC=C3)C1 CC1=CC(Cl)=CC=C1C(=O)NC[C@@H1]2CC[C@@H1](NC(=O)C3=CC(CC(C)C)=C[NH1]3)C2 N=C1N=C2C=C(C(=O)NC[C@H1]3CCCN(C(=O)[C@@H1]4C[C@H1]4F)C3)C=CN2[NH1]1 C[C@@H1](NC(=O)N1CCC[C@@]2(C1)CC2(F)F)[C@H1]3CN(C)CCO3 C=C1CCC(C(=O)NC[C@@H1](CNC(=O)C2=CC=C(F)C(C)=C2N)OC)CC1 CC=1C=C(C(=O)N2CC(OC(C)(C)C)C2)N3N=C(C)C=C3N=1 NC(=O)[C@@H1]1[C@H1]2CN([C@@H1](C(=O)NC3=CC=CC=C3)C4=NN=C5N4CCOC5)C[C@H1]21 CCC1(CC)C[C@@H1](NC(=O)[C@@H1](CC2CCC2)OC)CN1C(=O)C3=CC(Cl)=NO3 CC1=NNC(=O)[C@@H1]1CCC(=O)N2CCCC[C@@H1](NC(=O)C3=NC=C(C)C=C3C)C2 CCC1=CC(C)=NC(N2CC[C@H1](CNC(=O)[C@H1]3CCO[C@@H1]3CC)C2)=N1 NC(=O)C1=CN=CC(C(=O)N[C@H1]2CC[C@H1](NC(=O)C3=CCCC3)C2)=C1 CC[C@@H1](C(=O)N1CC[C@@]2(CCN(C(=O)C3=CC=NC(C(C)C)=N3)C2)C1)C(C)C N=C1[NH1]C(CC(=O)N2CCC[C@H1]2CNC(=O)CCC3=NC(C(F)(F)F)=N[NH1]3)=CS1 C#CCCOCC(=O)N[C@@H1]1CN(C(=O)C2=NC3=CC=CC=C3[NH1]C2=O)C[C@H1]1SC COC[C@@](C)(O)CC(=O)N1C[C@H1]2C[C@@H1]1[C@H1]2C(=O)N[C@H1](C(C)C)C3CC3 CC1=CC=CC=C1CC(=O)N2CC(C3(O)CN(C(=O)[C@]4(C)CO[C@H1](C)CO4)C3)C2 CC(C)C1=NC=C(C(=O)N[C@@H1]C2[C@H1]3C[C@@H1](NC(=O)C4=CC=C(N)C(O)=C4)[C@H1]3C2)S1 C=1C=C(CN[C@@]2(C3=NN=NN3C(C)C)CCC[C@@H1]2CCF)N(C4=CC=CC=C4)N=1 C=CCCCCCCN=C1C=C(C)N=C(N[C@@H1](C)C2=CC=C3N=C(O)OC3=C2)[NH1]1 CN(C[C@H1](O)CN(C)C(=O)[C@]12CCCC[C@@H1]1C2(F)F)C(=O)C(C)(C)C#N CCC1=NOC(CN(C)[C@@H1](C(=O)NCCSC)C=2C=C([N+1](=O)[O-1])SN=2)=N1 CO[C@@H1]1C[C@H1]1C(=O)NC[C@@H1]2CN(C(=O)C3(F)CCCCC3)CCCO2 C[C@@H1]1CN(CCN=C2[NH1]C(=N)[NH1]C(=NCC3=NN=C(O)N3C)[NH1]2)[C@@H1](C)CO1 CC=1C=C(C(=O)NC[C@H1]2CN(C(=O)CCN3CCCC3)CC[C@]24CCOC4)SN=1 O=C(CC1=CC=C2C(=C1)OCCO2)NCCCNC(=O)C3(F)CCC3 CCOC(=O)C(C)(C)CNC(=O)C[C@@H1]1C2=CC=CC=C2C(=O)N1C O=C(NC1=CC=C(Cl)C=C1F)C(=O)N2CCC[C@@H1]2CN(CCCO)C3CC3 N#CC=1C=CSC=1C(=O)N[C@@H1]2COC[C@@H1]2NC(=O)C#C[C@@H1]3CCCCO3 CN(C)C1=CC=C(C(=O)N[C@H1]2CN(C(=O)C3=CC=CN=C3F)CC[C@@H1]2F)C=C1 C[C@H1]1CCN1CC(=O)N[C@H1](C)CC2CN(C(=O)CC3CS(=O)(=O)C3)C2 CC[C@H1](OC)C(=O)N[C@@H1](C(=O)NCCCCNC(N)=O)C1=CC=CS1 CC1=NN=C2N1CCN(C(=O)[C@@H1]3[C@H1]4[C@H1]5C[C@H1]3[C@@H1](NC(=O)C6=CN=C(O)O6)[C@@H1]45)C2 O=C(N[C@@H1]1C[C@@H1]2CC[C@H1](C1)N2C(=O)[C@H1]3CCC[C@H1]3O)C=4N=N[NH1]C=4C(F)(F)F CC1=CC(C(=O)N2CCCC[C@H1](NC(=O)CC[C@@H1](C)O)CC2)=CC=C1Cl CC1(C)[C@H1]2CC[C@@H1](C2)[C@@H1]1C(=O)N3CCOC[C@@H1]3CCNC(=O)C45CSC(C4)C5 CC[C@@H1](C)CCCCC(=O)N(C)CCOCCNC(=O)[C@@H1]1NC(=O)[C@@H1]2C[C@@H1]21 CCCN([C@@H1](C(=O)NC1=CC=CC=C1Cl)C=2OC=CC=2C)[C@@H1]3CC(=O)NC3=O CN(CCNC(=O)[C@@H1](F)C1(O)CCCC1)C(=O)C2=COC(C3=CC=CN=C3)=N2 CCOCC1CCN(C(=O)[C@H1]2CN(C(=O)[C@H1]3C=CCS3)C4(CCC4)C2)CC1 C[C@H1]1CN(C(=O)[C@@H1](C)N2C=C(C3=CC=C(OC(F)F)N=C3)N=N2)C1(C)C CC1=CC(C(=O)N2CC[C@@H1](O)C[C@H1]2C(=O)N=C3[NH1]C=CN4C=CN=C34)=C(Br)C=N1 O=C(N[C@H1]1CC[C@@H1]1NC(=O)C2=NN=C(O)N=C2O)C=3C=NN(C4CCOCC4)C=3 CCC1=NC=NC(N2CC[C@H1](C)[C@@H1]2CNC(=O)C=3C=C(C)SN=3)=C1F CC1=CN=C(CN=C2[NH1]C(=NC[C@@]3(CO)CCOC3)[NH1]C4=C(F)C=CC=C24)C=N1 COC(=O)C1=CC=NC(O)=C1NC(=O)C=2SC=CC=2NC(=O)CN3CCCC3 C#CCCN1C([C@H1](C)F)=NN=C1N2CCN(S(C)(=O)=O)[C@H1](C)C2 CN(C[C@@]1(O)CCN(C(=O)C=CC=C(Cl)Cl)C1)C(=O)C[C@@H1]2COC[C@H1]2O C[C@H1]1CCN(C(=O)[C@H1]2C[C@@H1](N3C=NN=C3)C2)C[C@H1]1NC(=O)C4=CC=NN=C4 CON1C=NC(C)=C1C(=O)N2CC(O)(C(C)(C)CNC(=O)COC=3C=CSC=3)C2 COCN1N=CC=C1[C@H1](C(=O)NC2CCOCC2)N3CCC[C@H1](C#N)C3 C#C[C@]1(C(=O)NCC(C)(C)C(=O)OC)CCN(C(=O)C2=CC(C)=NC(O)=N2)C1 COC(=O)[C@@H1](NC1(C2=CC=C(Br)C=C2F)CC1)C(C)(C)O C[C@H1](CC(=O)N1CC2(NC(=O)C3=CN=C(O)C=C3O)CCC1CC2)C4=CC=CO4 CSC1=NC(Cl)=CC(N[C@H1]2C[C@@H1](NC(=O)CN(C)C(C)=O)C2(C)C)=N1 CC(C)C1=NC=CN1CC(=O)N[C@@H1]2CC[C@H1]2NC(=O)C3=CC(Cl)=C(N)C=C3F C=C[C@](C)(O)C(=O)N[C@H1]1CN(C(=O)C2=CC=C3N=C(C)[NH1]C3=C2)C[C@H1]1OC CC(C)C[C@H1](CNC(=O)C1=CC=NC(CN(C)C)=C1)NC(=O)CCC2=CN=N[NH1]2 C[C@@H1](C(=O)N[C@H1](CO)[C@H1](O)C1=CC=C(OC(F)(F)F)C=C1)N2C=NN=N2 CN(C)CC[C@H1](NC(=O)[C@@H1](CO)NC(N)=O)C(=O)NC1=CC=CC(C#N)=C1 C#CCCCCC(=O)N1CC(CNC(=O)C2(C(C)C)CCC2)(COC)C1 CCC1=CC=C(C(=O)N(CC(=O)NC[C@@H1](C)N(CC)CC)C2CC2)O1 COC1=CC=C(S(=O)(=O)N2CCC[C@H1]2CC(=O)NCC=3N=N[NH1]N=3)C=C1 C[C@@]1(O)CCN(CC(=O)NC[C@@H1](NC(=O)CCC2=CC=CC(O)=C2)C3CCC3)C1 O=C(CN1N=CC=N1)N[C@]23CC[C@H1](C[C@@H1]2N4C=C(COC5=CC=NC=C5)N=N4)C3 CCCCCCO[C@@H1](C)C(=O)N1CC[C@@](F)(CNC(=O)C2=CC=CC(F)=C2F)C1 COC1=C(C(=O)NC/C=C/C(=O)N2CC3(CCC3)C[C@@H1]2C)C=NN1C O=C(N[C@@H1]1CCN(C(=O)CN2C=CN=N2)CC[C@H1]1CO)C3=CN=CC(Cl)=N3 COCC1(NC(=O)C[C@H1]2C[C@@H1](OC)C2)CN(C(=O)C3=C(C)N=C(C)N3O)C1 C=CCNC(=O)[C@H1](C1=CC=C(C=2C=NN(C)C=2)C=C1)N(C)[C@H1](CC)COC O=C(NC[C@@H1]1CCCS1)[C@H1]2COC3(C2)CN(C(=O)C4(CO)CC(F)(F)C4)C3 C[C@H1](NC(C)(C)C)C(=O)NCCC1(O)CN(C(=O)[C@H1]2C[C@H1]3[C@@H1](C2)C3(C)C)C1 CC1=NOC(C)=C1[C@@H1](C)C(=O)N2CC(C)(NC(=O)CCCC3CC3)C2 CC(C)[C@@H1](C)C(=O)N[C@@]1(C(=O)NCC2(O)CN(C)C2)CCC(C)(C)C1 CC1=CC(C(=O)N2CC[C@](O)([C@@H1](C)NC(=O)C3=CCC3)C2)=CC(C)=C1N C[C@@H1](CNC(=O)C=1SC([N+1](=O)[O-1])=CC=1Cl)CNC(=O)C=2N=NN3C=2C(=O)NCC3 C[C@](CO)(CNC(=O)[C@@H1]1CCC(=O)N(C2CC2)C1)NC(=O)CC3=CC=CS3 CCN(C[S@](C)(=O)=NS(=O)(=O)CC1CC1)[C@@H1](C)CO CCC1=NC(C(=O)N2CC3(CCC[C@H1]3NC(=O)CC4CCC4)C2)=CS1 CSC1=C(NCC2(CC(C)C)CC2)N=C3C=CC=CN13 C#CCN(CC(C)C)C(=O)[C@H1](C)NC(=O)C1=CC(CC)=NC=N1 C=C(F)C1(CC(=O)N2CCOC[C@H1](CNC(=O)C3=CC=C(F)C=C3C)C2)CCC1 CCCS(=O)(=O)CC(=O)N1CCN(C(=O)CCCCC2=CC=CC=C2)C[C@@H1]1CF CCC(C)(C)C(=O)N[C@@H1]1CCCN(C(=O)[C@H1]2CN(C)C(=O)C3=CC=CC=C32)C1 NC1=CC=CC(CC(=O)N(CCC2=NC=CO2)C3CCCCCC3)=C1 CC[C@@H1](CN(C)C(=O)CCN1N=C(C)N=C1C)NC(=O)[C@@H1]2COC[C@H1]2C(=O)OC O=C(N[C@@H1]1CCS(=O)(=O)C12CN(C3=NN=CS3)C2)C4=CC=CC=5C=C[NH1]C4=5 C=C=C[C@@H1](C)C(=O)N1CC[C@](C)(C(=O)NC[C@@H1]2CCCO2)C1 CC(C)[C@@H1](CNC(=O)CC1CCOCC1)NC(=O)C[C@H1](C)C(F)F CN1C(O)=NC=C(C(=O)N[C@H1]2CCN(C(=O)[C@]3(F)CCS(=O)(=O)C3)C2=O)C1=O CCCN(C)CCC(=O)N[C@H1]1C[C@@H1](C)CN(C(=O)C2=CC=C3C(=C2O)CCC3)C1 C[C@@H1](NC(=O)[C@@H1]1C=CCN1C(=O)C2=CC=C(C#N)C=C2F)C3=CC=CS3 O=C(CC1=CC=CC(Br)=C1)CN2CC[C@@H1](O)[C@H1](F)C2 CCC(CC)[C@H1](O)CNC(=O)[C@@H1]1CC[C@H1](C)N1C(=O)CN(CC)CC CC(C)(C)OC(=O)N1CCCN(C(=O)C2=CC(Cl)=NC=C2Cl)C[C@H1]1C(F)(F)F C[C@@H1](NC(=O)C(C)(C)CN(C)C)C1CN(C2=NN=C(C3CCCC3)S2)C1 CCC1=CC(C(=O)NC[C@@H1](CNC(=O)C2(C(C)(F)F)CC2)OC)=NO1 CCCCCC[C@@](C)(N[C@H1](C(=O)N(C)CC)CC)CC(=O)OCC CN(C)CCCCC(=O)NC[C@]1(C(=O)N2CCCNC(=O)CC2)CCCO1 C#CC1[NH1]C2=CC1=CC=C2C(=O)OCC3=NN=CN3CC CN(CCN1CCCC1)C(=O)C(C)(C)[C@H1]2CCN(C(=O)C=3C=C(CCO)ON=3)C2 CN(CCCCN(C)C(=O)[C@]1(C)CC(C(F)(F)F)=NO1)C(=O)C=2[NH1]C=NC=2C#N CCC=1N=C(C)[NH1]C=1C(=O)N[C@@H1]2CCN(C3=CC(=O)N(C)C=N3)C[C@@H1]2O C=COCCCNC(=O)[C@@H1]1CCC=2N=C(C3=CC(C(=O)OC)=CC=C3C)SC=2C1 CCCC(=O)N1C[C@]23CCCC[C@@]2(C1)CN(C(=O)COC[C@@H1]4CCCCO4)C3 CN(CC(C)(C)CO)C(=O)[C@@]12CC[C@@H1](CN(C(=O)C34CC(F)(C3)C4)C1)C2 CC=1N=C(C(C)C)OC=1C(=O)N2CC[C@](O)(CNC(=O)[C@H1]3C[C@@H1]4CC[C@H1](C3)O4)C2 COC1(C(=O)N(C)C[C@H1]2CCCN2C(=O)[C@]34CC[C@H1](CC3)C4(C)C)CC1 COCCC1=CC(C(=O)N[C@H1]2CCN(C(=O)[C@@H1](C)C(=O)N3CCOCC3)C2)=NO1 C[C@H1](NC(=O)CN1N=CN=N1)[C@H1]2C[C@H1]2C(=O)N3CCO[C@H1](C)[C@H1]3CO O=C(NC1CC(CNC(=O)C2=CC=3SC(Cl)=CC=3S2)C(CO)C1)C4=NC=CC=N4 CC=1N=C(CNC(=O)[C@@H1](F)CC2CN(C(=O)C3(C(N)=O)CC3)C2)SC=1C CC[C@@H1]1CN(C(=O)[C@H1](CO)NC(=O)C(C)C)CC[C@H1]1NC(=O)C(C)(C)C CC1=CC2=C(Br)C=CC=C2C(NC(=O)[C@@H1]3CC=C[C@H1](O)C3)=C1 C[C@H1]1CN(C(=O)CN2C=C(CO)N=N2)C[C@@H1]1C(=O)N(C)[C@@H1]3COC(C)(C)C3 CC1=NO[C@H1](CC(=O)NC[C@H1]2C[C@@H1](C(=O)N3CC4(CC4)C[C@H1]3C)C2)C1 CC[C@H1](CN(C)C(=O)[C@H1]1C[C@H1]1CN(C)C)NC(=O)CC=2C=C(Cl)N(C)N=2 CC(C)(C)C=1C=C(C(=O)NC[C@H1]2CCC[C@@H1](NC(=O)[C@H1](F)N3C=CC=N3)C2)ON=1 C[C@@H1]1CN(C(=O)C2=C(F)C=CC(N)=C2F)CCN1C(=O)[C@H1]3CCC(C)(C)C3 C[C@@H1]1C[C@@H1](C(=O)NC2=CC=NC(Cl)=C2Br)N(CC3=CC=C(I)C=C3O)C1 CC(C)N1C=C2N=CC(C(=O)N3C[C@H1]4C[C@@]4(CNC(=O)C5(F)CCC5)C3)=CC2=N1 CCC[C@H1](CC(=O)NC1=CC=C(C)C(CC)=C1)NC(=O)[C@@H1]2CSCC(=O)N2 CC(C)N1CC(C(=O)N2C[C@H1]3C[C@H1](O)[C@@H1]2[C@@H1]3NC(=O)C4CCOCC4)C1 CC(C)(C)C1=CC=CC([C@@H1](C(=O)NC[C@H1]2CCOC2)N3C[C@H1]4C[C@@H1](O)C[C@H1]4C3)=C1 CN(C(=O)C1=CC=CC(Br)=C1)[C@H1]2CC[C@@H1](NC(=O)C3=CC=NS3)C2 CCN1N=CC(C(=O)N2C[C@@H1]3C[C@H1]2CN3C(=O)CCOC4=CC=CC=C4Cl)=C1C N=C1C=C(C(=O)N2CCC[C@H1](NC(=O)COC[C@H1]3CCCOC3)C2)N=C(Cl)[NH1]1 C#CCNC(=O)[C@@H1]1CN(C(=O)[C@H1](C)CN(C)C)CC(C)(C)C1 CC(C)[C@@H1]1OCC[C@H1]1C(=O)NCC2=N[NH1]C=C2C(=O)NC[C@@H1]3CCCC34CCC4 CC=1C=C2C=CC(C(=O)N3CCC[C@H1]3[C@H1]4CCN(C(=O)C56CC(C5)C6)C4)=CN2C=1 C[C@H1]1CN(C(=O)C=CC=2C=CSC=2)C[C@@H1](C(=O)N(CCO)CC(C)(C)C)O1 CC1=CN=C(C(=O)N2CCCC[C@H1](CCC(=O)N3CCC[C@H1](C(C)C)C3)C2C)N1 C1[C@H1]CN(S(=O)(=O)C2=CC=C(C(=O)O)C=C2)C[C@@]1(C)CNC(=O)OC(C)(C)C C=CCCCCN(C)C(=O)[C@H1]1CN(C(=O)CS(C)(=O)=O)CCN1C COC(=O)COCC(=O)N1C[C@@H1](C)[C@@H1](NC(=O)[C@H1]2C[C@@H1](O)C3=CC=CC=C32)C1 CC1=CC(C(=O)N2CCCC23CCN(C(=O)C4(F)CC=CC4)CC3)=C(F)C=C1Cl CC(=CC1=CC(F)=CC(F)=C1)CNCC2=NOC(C3=CC=CO3)=N2 CC(C)N1N=CC=C1CN2C[C@H1]3C[C@@H1]2CN3C(=O)CCC4=CC=C(Br)C=C4 COC(=O)C=1SC=C(C)C=1NC(=S)N2CCN(CC3=CN=CS3)CC2 CC1=CC2=C(C=C1Cl)[C@@H1](N3C=C([C@@H1](C)NC(=O)C=4[NH1]N=NC=4C)N=N3)CO2 CC[C@@H1]1C[C@@H1]1C(=O)N2CCC[C@H1](N(C)C(=O)[C@H1](C)NC(C)=O)CC2 CC(=O)NCCCNC(=O)C[C@H1](O)CNC(=O)CCCN1C=CC=N1 CCC(C)(C)[C@@H1](C)CC(=O)N[C@H1]1CC[C@H1](NC(=O)CC2=CC=CC=C2O)C1 CC1=NN([C@H1]2CCS(=O)(=O)C2)C(Cl)=C1CNC3CC(CCF)C3 CCCC1(C(=O)N[C@@H1](CNC(=O)C(C)=CC2=CC=CC=N2)C3CCCC3)CC1 C=C[C@@H1](O)C(=O)NC[C@@]1(C)COCCN(C(=O)CC=2OC3=CC=CC=C3C=2C)C1 C[C@]1(NC(=O)C(F)(F)F)CCCN(C(=O)[C@H1]2CCCN(C3=NC=CC=N3)C2)C1 CC[C@@H1]1C[C@@H1](CC(=O)N2CCC[C@@]23CCCN(C(=O)C=CSC)C3)CCO1 CN1CCN(C(=O)[C@H1]2CC(=O)N(CCC3=CC=CC=C3)C2)C[C@@H1]1CO O=C(CCC1=CC=C(Cl)S1)N2CCN(C(=O)[C@@H1]3CCS(=O)(=O)N3)[C@@H1]4CC[C@H1]42 O=C(NC1=CC=NC(Br)=C1F)[C@H1]2CC3(CC3)CN2C(=O)C4=CC(Cl)=C(Cl)S4 CSC1=CC(Cl)=CC(C(=O)N2CC=C[C@@H1]2CNC(=O)[C@H1]3CCCS3)=C1 CC1=NC(O)=NC(C)=C1C(=O)N2C[C@@H1](NC(=O)CC(C)(C)C#N)C3(CC3)C2 CCO[C@@H1]1C[C@H1]1C(=O)N2CC[C@@H1]3CN(C(=O)C4=CN=C(C(C)C)N=C4C)CC[C@@H1]32 CCOC(=O)CC1CCN(C(=O)[C@H1](NC(=O)COCC2CC2)C(C)C)CC1 C[C@H1](NC(=O)C1CC(=O)N(C2=CC=CC=C2)C1)[C@@H1](CO)NC(=O)C3CSC3 CC(C)N(CCN(C)C(=O)[C@H1]1CC2(CCC2)CO1)C(=O)[C@@H1](C)C(F)F CC[C@@H1](O)[C@H1](C)C(=O)NCC(C)(C)C1(O)CN(C(=O)C2=C(C)N=CN2OC)C1 C[C@H1](CNC(=O)C=1C=CC2=NON=C2C=1)N(C)C(=O)CN3N=CC4=NC=CC=C43 CN(C)C[C@H1](O)CC(=O)N1CCC[C@@H1](CNC(=O)C[C@@H1]2CC2(Cl)Cl)C1 CCCOCCC(=O)N[C@@H1](CNC(=O)C1=CC=C(OC)C(C)=C1)C2CCC2 C[C@H1]1CCC[C@@H1](CC(=O)N[C@@]2(C(=O)N3CCN4C=CN=C4C3)CCC[C@@H1]2C)O1 CCNC(=O)[C@@H1](C1=NOCC1)N2CCC(C(=O)NCCN(C)C)CC2 CCOCC[C@H1](NC(=O)C[C@@]12CCC[C@@H1]1C2)C(=O)N(C)[C@H1]3CC[C@@H1]3C CN(C)CC(C)(C)CC(=O)N1[C@H1]2CC[C@@H1]1C[C@@H1](N(C)C(=O)COCC(C)(C)C)C2 O=C(NC[C@@H1]1C[C@H1](CNC(=O)C2(Br)CC2)CO1)C(F)(F)CO CC[C@@H1](C(=O)N1CC[C@@](N=[N+1]=[N-1])(C(=O)NCCN(CC)CC)C1)N(C)C CNC1=C(F)C=CC=C1C(=O)N2CCO[C@@H1]3CN(C(=O)CS(=O)(=O)NC)C[C@@H1]32 CC[C@@](C)(COC)NC(=O)[C@H1]1CCCC[C@H1]1CNC(=O)[C@H1]2CCC(=O)N(C)C2 CN(C(=O)C1=CC=CC(C(C)(F)F)=N1)[C@H1]2CCN(C(=O)C=CC=3C=C[NH1]N=3)C2 C=CCN(CC1CCCCC1)C(=O)[C@@H1]2CN(CC(C)(C)C(=O)O)CC[C@@H1]2O O=C(CNC(=O)C1=CC=CC(Br)=C1)NC[C@H1]2CC23CCS(=O)(=O)CC3 O=C(C#C[C@H1]1CCCO1)N[C@H1]2CCC[C@H1]2NC(=O)CCCN3CCCCC3 CCCOC1=NC(C)=CC=C1C(=O)N[C@H1](CO)[C@@H1](C)NC(=O)C=2OC=CC=2C CCOC(=O)C=1SC([C@H1](C)NC(=O)C(=O)NC[C@H1]2C(F)(F)C23CCC3)=NC=1C CCC[C@@H1](OCC)C(=O)N1CC=C(C(=O)N(C)CCCCOC)C1 CC[C@](C)(CNC(=O)C1=CON=C1C)NC(=O)C2=CN=C3SC=CN3C2=O O=C(C1=NC=NC=C1Br)N2C[C@@H1](CNC(=O)C3(F)CC3)C4(CCC4)C2 C[C@H1]1OC2(C)CCC1(C(=O)NCC#CCNC(=O)CN3CCCCCC3=O)CC2 CO[C@H1](C(=O)N1C[C@H1](C)C(NC(=O)[C@@H1]2[C@@H1](C=C(C)C)C2(C)C)[C@@H1](C)C1)C3CCC3 CNC(=O)[C@H1](C1=CN=C(C2CC2)N=C1)N3CC[C@H1](C4=CC=CC(F)=C4)[C@H1](O)C3 C[C@@H1](O)C1=CN(CC(=O)NC[C@@H1]2CCCN(C(=O)COCCN(C)C)CC2)N=N1 CCS(=O)(=O)N(C)CC(=O)N1CCN(C(=O)CC(C)(C)O)[C@H1](C)[C@H1]1C O=C(N[C@H1](CN=C1C=CN2C=CN=C2[NH1]1)C3CCCC3)C4=CC=C5C(=C4)COC5 COCCSCC(=O)N1CCC[C@@H1]1C2(C(=O)N3C[C@@H1]4[C@@H1](C3)C4(F)F)CC2 O=C(CC[C@@H1]1CCOC1)N[C@@H1]2[C@H1]3C[C@@H1]4CN(C(=O)[C@@H1]5CSCC(=O)N5)[C@@H1]2[C@H1]4C3 CC1CN([C@@H1](C)C(=O)NCC2=CC=C(C(=O)NC3(CCF)CCC3)S2)C1 CCCN(C(=O)C=C[S@@](C)=O)C1CCN(C(=O)[C@H1]2C[C@@H1](O)CN2C)CC1 FCCN1N=C(C2=CSC=N2)N=C1C3CCSCC3 C#CCN(CC(=O)N1C[C@H1](C)O[C@@H1](C)C1)C(=O)[C@@H1]2C[C@H1]3C=C[C@@H1]2O3 CCN1CCC[C@@H1](NC(=O)[C@H1]2[C@H1](CNC(=O)CCCCSC)C2(C)C)C1 COC1=CC(C)=C(C(=O)NC[C@H1]2CC[C@H1]2NC(=O)[C@H1](O)C=3C=CSC=3)C(F)=C1 CO[C@@H1](C(=O)NC1(CNC(=O)C2=CC(F)=C(C)C=C2F)CCCC1)C(C)C C=C(C)COC1=CC=CC(NC(=O)C2=CC=CC(N)=C2)=C1 CCC=1C=CSC=1C(=O)NNC(=O)C2=CC=CC(N(C)C)=C2 CCC[C@@H1](NC(C)=O)C(=O)N1CC[C@H1]1CNC(=O)C(=O)C2=CC(OC)=CC=C2Cl CC[C@H1](NC(=O)[C@@H1]1CCC[C@@H1]1NCC=2C=CC3=C[NH1]N=C3C=2)C4=CC=CC=C4Cl CCC[C@@H1](C)CC(=O)N1[C@H1](CNC(=O)C=2C(Cl)=CSC=2Cl)C[C@@H1]3C[C@@H1]31 C[C@@H1]1CN(C(=O)[C@H1]2CCC3(CCC3)O2)C[C@@H1]1NC(=O)[C@H1]4CC[C@H1](C)CC4 O=C1C[C@@H1]2CCC[C@@]2(NC(=O)NCC(F)(F)C3=CC=CC=C3F)CN1 CC[C@@H1]1CCN(C(=O)C2=CC=3SC=NC=3[NH1]2)[C@H1]1CNC(=O)C45CCC(C4)C5 COC1=CC=C(C(=O)N(C)CC[C@@H1](C)NC(=O)[C@@H1]2CC[C@H1]3C[C@@H1]2C3(C)C)C=C1F CC1=NN(C)C(C)=C1C2=CC=C(CNS(=O)(=O)C3=CC=C(O)C=C3)C(F)=C2 CC1(C(=O)N2CCC[C@H1]2C3(NC(=O)C=4C=NN5C=4OCC5)CC3)CC1 CC[C@H1](CN(C)C)C1=NC(CC2=CC=C(Br)C=C2)=NN1C3=CC=C(Cl)C(Cl)=C3 CN=C1C=CC(C(=O)N2CC[C@@H1](C(C)(C)NC(=O)C3=CN=NC=C3OC)C2)=C[NH1]1 O=C(NC[C@H1]1[C@@H1]2C[C@H1]1CN2C(=O)CN3CCCC3=O)C=4N=C[NH1]C=4C(F)(F)F CC[C@@H1]1[C@@H1](NC(=O)C2=CSC(Br)=C2C)CCN1C(=O)C3=NO[C@H1](C)C3 COCCC(=O)NCC1=NOC=C1C(=O)N2CC(F)C2 O=C(NC[C@H1]1[C@@H1]2CN(C(=O)CC3CS(=O)(=O)C3)C[C@H1]12)C4=CC=C([N+1](=O)[O-1])C=N4 CN(CC(=O)O)C(=O)CN1CC[C@@H1](C2=NC(C3CC3)=NO2)C1 OC[C@@H1](CN[C@H1](C=1SC=NC=1Cl)C2=NN=NN2CCC3CC3)C4=CC=C(Cl)C=C4 C[C@H1](NC(=O)C1=CSC([N+1](=O)[O-1])=C1)[C@H1]2CN(C(=O)C=3[NH1]N=NC=3C4CC4)CCO2 O=C(NC[C@]1(F)CCN(C(=O)C2=CC(Cl)=C[NH1]2)C1)[C@@H1]3CC=CC4=CC=CC=C43 COC1(CNC(=O)[C@@H1]2C[C@@H1](C)C2(C)C)CN(C(=O)CC34CCC(CC3)OC4)C1 O=C(CN1CCCCC1)NC[C@H1]2CN(C(=O)C[C@@H1]3CCC3(F)F)CC24CCC4 O=C(C1=CN=NC(O)=C1)N2CC3(CCN(C(=O)C4=CC(Cl)=C(O)C=C4F)CC3)C2 C[C@@H1](NC(=O)C1=CC=CC(O)=C1F)[C@@H1](C)NC(=O)C2=CSC(C(F)(F)F)=C2 CCN1C=CN=C1C(=O)N[C@@H1]2CC[C@H1](NC(=O)CN3C=C(F)C=CC3=O)C2 CCOC1=CC=C(C(=O)NC[C@H1]2CC(F)(F)CN2C(=O)C3=NC=CC=C3N)C=N1 CC1=CC(COCC(=O)N[C@@H1]2C[C@H1]2CNC(=O)C=CC3=NC=CS3)=NO1 C=C(C)C[C@H1](NC(=O)CCC(C)=O)C(=O)N[C@H1]1CC[C@@H1](C2CC2)C1 CC1=CC(NC(=O)C23CCC(CC2)N(C(=O)[C@@H1](C)C(C)(C)C)C3=O)=C(C)S1 CC1=CC(C(=O)N[C@@H1]2C[C@@H1]2CNC(=O)C=3C=NOC=3C)=CC=C1C(F)(F)F C/C=C/CCCCC(=O)N[C@@H1]1C=CCN(C(=O)[C@H1]2C[C@H1]3O[C@@H1]2[C@@H1]4C[C@H1]34)C1 CN(C)CC(C)(C)NC(=O)[C@@H1]1CC[C@H1]2CC[C@H1]1N2C(=O)[C@H1]3[C@H1]4CCC(F)(F)[C@@H1]34 COC1=CC(N)=CC=C1C(=O)NCCCNC(=O)C2=NC3=CC=CC=C3N=C2O CC1=CC(C(=O)N2CC[C@H1](NC(=O)CNC(=O)[C@H1]3C[C@@H1]3C)[C@@H1](C)C2)=CC=N1 CNC(=O)[C@H1]1CCN(S(=O)(=O)C2=CC=C(N[C@H1](C)CCO)N=C2)C1 C[C@@H1]1CC[C@H1](CCC(=O)N2[C@H1]3CC[C@H1]2CC(N(C)C(=O)[C@H1]4CC4(C)C)C3)O1 COC1=CC(C(=O)NC[C@@H1]2C[C@@]23CC3(F)F)=NN1C CC(=O)C(=O)N1CCC(C)(CNC(=O)C[C@H1]2CCOC(C)(C)C2)CC1 CC1=CC(Cl)=CC(C)=C1C(=O)NC[C@@]2(F)COCCN(C(=O)C=3N=N[NH1]C=3Cl)C2 C#CC1=CC=CC(C(=O)N2[C@H1]3CC[C@H1]2[C@H1](CNC(=O)C4=CC=C(OC)C=C4)C3)=C1 C=C[C@H1](C)CC(=O)N1CCC([C@@H1](C)C(=O)NOC(C)C)CC1 CCCN(CC(=O)[C@@H1]1C=CCCC1)C(=O)C[C@@H1](O)CC(C)C CC1=CC=CC(C(=O)NC[C@H1](C)C2CCN(C(=O)C3=CC=CO3)CC2)=C1F C#CC1(O)CN(C(=O)C[C@@H1]2CN(C(=O)C(Cl)Cl)CCO2)C1 CC[C@H1](C)[C@H1](C)C(=O)N1C[C@@H1](NC(=O)C=2C=COC=2Cl)[C@H1](OC)C1 C=C[C@H1](O)C(=O)N1CCO[C@@](C)(CNC(=O)C(C)(C)C2=CN=CS2)C1 CC(=CC(=O)N1C[C@@H1]2C[C@H1](C1)CN2C(=O)CC3CCC(=O)CC3)C4CCCCC4 COCCC[C@H1](C)C(=O)N[C@@H1]1CN(C(=O)[C@@](C)(NC(C)=O)C(C)C)C[C@@H1]1C CCOC1=CC=C(C(=O)N[C@@H1]2CN(C(=O)[C@H1](C)C=3C=NN(C)C=3)C[C@@H1]2C)C=N1 O=C(C1=CC=C(Br)C=C1CO)N2CC[C@H1]3[C@@H1](C2)CN3C(=O)[C@H1]4CC45CC5 CCOC(=O)C[C@@H1]1CCN(C(=O)N=C2N=C(C3CCCCC3)[NH1]S2)C1(C)C CN1C(=O)CC[C@@H1]1C(=O)N[C@H1](CNC(=O)CSC(F)F)CC(F)(F)F CC(=O)OCC(=O)N1CCC12CN(C(=O)C3=CC=C(F)C4=CC=CC=C34)C2 CC1=CN(C)N=C1C(=O)N2CC=C[C@H1]2CNC(=O)[C@@]3(Br)CC3(F)F C=C(C)C[C@H1](C)C(=O)N1C[C@@H1]2C[C@H1]1C[C@H1]2CNC(=O)/C=C/C(F)(F)F CSC1=NC=C(CNC[C@@H1]2CCCCN2C(=O)C3=CC=C(C(N)=O)C=C3)C=N1 C[C@H1]1CCC[C@H1](C)C1NC(=O)C=2[NH1]C(O)=NC=2C3=CC=CC=N3 CC1=CC=CC(F)=C1C2=CC=C(CNC(=O)CC3=C(Cl)C=CC=C3Cl)C=N2 CC1=CC(C(=O)NC[C@H1]2C[C@@H1](NC(=O)CC3CCC(F)(F)CC3)C2)=CC(N)=C1Cl O=C(C=CBr)NCCCCNC(=O)C1=N[NH1]C=C1C2=CC=CC=C2 CCNC(=O)C(C)(C)CNC(=NCCC(=O)NC)N[C@H1]1C[C@]12CCC3=CC=CC=C32 CC1=C(C(=O)NC[C@@]2(NC(=O)C3=CC(Cl)=C(C(F)F)C=C3F)CCOC2)N=CN1 CC1=NOC2=CC(C(=O)N3CC[C@@](C)(NC(=O)[C@@H1]4CC(C)(C)CO4)C3)=CC=C12 CC=1C=C(C)N(CCC(=O)N2CCN(CC3=CC=C(O)C=N3)C[C@@H1]2CC#N)N=1 CCO[C@H1](C)C1=NC=C(C(=O)N2CC3(CN(C(=O)CCC4=CC(C)=NO4)C3)C2)S1 CCOC1=CC(C)=C(C=2C=NC3=N[NH1]C=C3C=2C(=O)NC=4SC=CC=4C#N)C=N1 C[C@@H1]1CCC=2[NH1]C(=N[C@@H1]3CC[C@H1]4C[C@@H1]3CO4)[NH1]C(=NCCCCC#N)C=2C1 CC1=CC(CC(=O)N[C@@]2(CNC(=O)CS(C)(=O)=O)CCCC[C@@H1]2CC)=NO1 CC=1N=C(Br)OC=1C(=O)NCC23CC(NC(=O)C4CC(C(F)F)C4)(C2)C3 CN1N=NC2=CC(C(=O)NC[C@@H1]3CCCN3C(=O)[C@@H1]4CCC(C)(C)OC4)=CN=C21 O=C(C1=COC=N1)N2CC[C@H1]3CCN(C(=O)C4=CC(Cl)=C(Cl)C([N+1](=O)[O-1])=C4)[C@H1]3C2 CC1(C)CC(C)(C(=O)N2CC[C@@H1](CCNC(=O)[C@H1](O)C(F)(F)C(F)(F)F)C2)C1 COCC1=CSC(C(=O)N(C)[C@H1]2CCCN(C(=O)C3=CSC=C3C4CC4)C2)=C1 CN(C(=O)[C@@H1]1CCCC2=CN=CN21)[C@H1]3CCN(C(=O)C(C)(C)CC4CC4)C3 CC1=CC(C#N)=C[NH1]C1=N[C@H1](CNC(=O)C(C)(C)C2=CC=CS2)[C@H1](C)C(C)C C=CCCCN(C)CC1CCN(C(=O)CC2=CC=C(C)O2)CC1 O=C(N1CCCC(CN2CCCC2)C1)C3(N4N=CC5=CC=CC=C54)CC3 CC1=NSC(N)=C1C(=O)N2CCN(C(=O)CC(F)F)C[C@@H1](O)C2 C#C[C@H1](C)C1CCN(C(=O)C2CC(CCNC(=O)[C@@H1]3[C@H1]4CC[C@@H1](C4)[C@H1]3C)C2)CC1 C[C@H1]1C[C@@H1](NC(=O)C2=CC=NC(C#N)=C2)CCN1C(=O)C3=CN=C4C(=C3)CCC4 CCC1=NC(=N)[NH1]C=C1C(=O)NC[C@]2(F)C[C@@H1](CNC(=O)C3=NSN=C3O)C2 CCCCN1C=C(C(=O)N2C[C@@H1](NC(=O)CCCSC(C)(C)C)CC[C@H1]2C)N=N1 C=C1CC[C@@H1]1C(=O)N2C[C@@H1]3C[C@H1]2[C@@H1]3CNC(=O)C4=NC=NC(C)=C4C C[C@H1](NC(=O)C1=CCCN(C(=O)C[C@@H1](C)C(C)(C)C)C1)C2=NC=CS2 COC1=CC=C(CC(=O)N2CC([C@@H1]3CCCN(C(=O)CC(C)C)C3)C2)C(Cl)=C1 CCN(CC)CC(=O)NC(C)(C)COCCCNC(=O)C[C@@H1]1C[C@@H1](O)C12CCC2 NC1=CC(O)=CC(C(=O)N2CCC(NC(=O)C=3C=NN(C4CCC4)N=3)CC2)=C1 CCC[C@H1](C(=O)N1C[C@H1](NC(=O)CC2=CC=CC=[N+1]2[O-1])CC13CCC3)C(C)C COC1=NC=C(C(=O)NCC2=NC(CNC(=O)[C@H1]3CCC(C)(C)O3)=CS2)C(C)=N1 O=C(N[C@]1CC2[C@H1](C[C@@H1]1N3C=C(CN4C[C@H1]5C[C@@H1]5C4)N=N3)C2)[C@H1]6CCC[C@H1]6O CN(CCO)CCC(=O)NC[C@@]1(F)CC[C@H1](NC(=O)C2=CC=NN2C(C)(C)C)C1 C=C1CC(C(=O)N[C@H1]2CCCC23CN(C(=O)[C@H1](C)OC4=CC=C(SC)C=C4)C3)C1 O=C(N[C@@H1]1C[C@H1]2[C@@H1]1CCN2C(=O)C3=CN=C4N3CCCC4)C5=CC(O)=CC=C5Cl O=C(NC[C@@H1]1CCCN1C(=O)C=CC2=CC=CO2)[C@@H1]3CC4(CCCC4)CO3 O=C(NC[C@@H1]1CC2(CC2)CN1C(=O)C3(C4CCC4)CC3)C5C6CC7CC(C6)CC5C7 C[C@H1](CC(=O)N[C@H1]1COCC[C@H1]1C(=O)NCC2=CC=CC=C2C#N)CC(C)(C)C CC[C@@H1](CC(C)C)C(=O)NCCCN(C)C(=O)C1=CC=CC2=C1C=CN2C(C)C CCN1N=CC(Br)=C1C(=O)NCCC2=CN(C=3C=CSC=3C(=O)O)N=N2 CC1=C(C(=O)NC2CCC(CNC(=O)CCC=3C=C(C)SC=3C)CC2)SCCO1 CC1=NC=CC=C1C2=CN(C(C)(C)CC(=O)N3CC[C@H1](C)C[C@@H1]3CO)N=N2 C[C@H1]1CN(C2=CC=C(C(=O)N3C[C@H1](O)[C@@H1](OC(F)F)[C@H1]3C)C=C2)C[C@@H1](C)O1 CS(=O)(=O)CC1=CC=CC=C1C(=O)NCCC(=O)NC(N)=O CCN(C)C(=O)OC[C@@H1]1CCCCN1[C@@H1](CCC2CC2)C(=O)NCCOC C[C@@H1]1CC(F)(F)CN1C(=O)[C@H1]2COCCN(C(=O)[C@@H1]3[C@H1](C#N)C3(C)C)C2 COCC(=O)NC[C@H1](C)NC(=O)C1=CC=C2N=CC=C(C)C2=C1 CO[C@H1]1CCCC[C@@H1]1C(=O)N[C@H1]2CN(C(=O)C3(C(C)(F)F)CC3)CC4(CC4)C2 CCC1(CNC(=O)COC2=C(Cl)C=C(C)C=C2Cl)CCCCC1 CC[C@@]1(C)C[C@@H1]1C(=O)N2CC(CO)(NC(=O)COCC3CCOCC3)C2 C[C@@H1](CNC(=O)CN(C(=O)[C@H1]1O[C@H1]2CC[C@H1]1C2)C3CC3)N4CCCC4 CC(=O)CCCC(=O)N[C@@]12CCCCC[C@@H1]1N(C(=O)C3CC(C)C3)CC2 C=CCCC(=O)N1C[C@@H1](NC(=O)/C=C/C2=CN=C(C(C)(C)C)S2)C[C@@]1(C)CC CNC(=O)COCC(=O)N1CCN(C(=O)[C@@]2(O)CC2(C)C)C[C@H1]1C=3C=N[NH1]C=3 CCOC1(C(=O)N2CCCC[C@H1]2CNC(=O)C=3N=CSC=3NCC)CCCC1 CC(C)[C@H1](C(=O)N1CC(CO)C1)[C@@H1](C)NC(=O)COCC2CCCC2 O=C(C[C@@H1]1C(=O)NC2=CC=C(Br)C=C2N1)N[C@@]3(C(F)(F)F)C[C@H1]4CC[C@@H1]3C4 CCN(C[C@H1](C)NC(=O)CC1=CC=C(C(N)=O)N=C1)C(=O)CC2=CCCC2 CN1N=CC2=C(N[C@H1]3C[C@@H1]3C(=O)N(CC4=CC=CC=C4)C[Si](C)(C)C)N=CN=C21 O=C1CO[C@H1](C(=O)N2C[C@H1]3C[C@]3(CNC(=O)C4=CC=C(F)C(Cl)=C4F)C2)C1 C[S@@](=N)(=O)C1CN(C(=O)[C@@]2(F)CCN(C(=O)C3=CC=C(O)C=C3)C2)C1 N#CC1=CC(C(=O)N2CCOC[C@@](F)(CNC(=O)C3=CC(Br)=N[NH1]3)C2)=CS1 CCC1=NC(C(=O)N[C@H1](CCF)C(=O)N2CCN3C(=O)NC[C@@H1]3C2)=CS1 CC1=NSC(NC(=O)CN2CCN(C(=O)[C@H1]3C[C@H1]3C4CC4)CC2)=C1C#N C[C@H1](CC(F)F)C(=O)N1CC(CNC(=O)CSC[C@H1]2CCCO2)(C(N)=O)C1 CC(C)[C@@H1](CCN(C)C(=O)C1=COC(N(C)C)=N1)NC(=O)C2CC(C)(C)C2 CC(C)(C)C1=NC=C(C(=O)N[C@@H1]2CCCN(C(=O)[C@H1]3C[C@@H1](C#N)C3)CC2)C=N1 CC1=NC=C(C(=O)N[C@H1](CN(C)C)C(=O)NCC2=CC=NC=C2F)C(C)=N1 CCCN(C(=O)[C@H1]1CCCN2C=NN=C21)C3CCN(C(=O)CN4CC[C@@H1]4C)CC3 CP(C)(=O)C1=CC=C(C(=O)N2C[C@H1]3CCN(C(=O)C4=NC=C[NH1]C4=O)[C@H1]3C2)N=C1 C=CCCC(C)(C)C(=O)N[C@@H1]1C[C@@H1](C)CN(C(=O)[C@@H1]2C[C@H1](O)[C@@H1](F)C2)C1 COC1=CC=C(C(=O)N2C[C@H1]3[C@H1](CNC(=O)CCN(C)CC(F)(F)F)C[C@H1]3C2)S1 COC1=CC(F)=C([C@H1](N)C(=O)N(C)CC2=CC=C(F)C(F)=C2)C(Cl)=C1 COCC1=NOC=C1C(=O)N2CC(CNC(=O)[C@@H1]3CCCC4=CC=NN43)(OC)C2 CC1(C)[C@@H1](CNC(=O)C[C@@](C)(O)C(F)(F)F)CCN1C(=O)C=2[NH1]N=CC=2C#N COC[C@@]1(C(=O)NC[C@@H1]2C[C@@H1](O)[C@H1](NC(=O)C3=CC=C(O)C=N3)C2)CCCOC1 CC1=NC=CC=C1C(=O)N2C[C@H1](O)C[C@@H1]2C(=O)NC3CCN(C)CC3 C=CC=CCC(=O)N[C@H1]1C[C@]12CCN(C(=O)C3=CC(C)=C(C)C=N3)C2 CC1=NO[C@H1](C(=O)NCCO[C@@H1]2CCN(C(=O)CC3(C(F)(F)F)CCC3)C2)C1 C[C@@H1]1C[C@@H1](NC(=O)C[C@H1]2C[C@@H1](O)C2(C)C)CCN1C(=O)C3=CC=C(Cl)C(F)=C3N CC1=NC(NCC2(O)CN(C(=O)[C@@H1](C)N3C=C(Cl)C=N3)C2)=C(Cl)C=C1[N+1](=O)[O-1] CCCC1=CC(C(=O)N(C)[C@H1]2C[C@@H1](NC(=O)[C@H1](C)N3CCCCCC3)C2)=NN1C CC(C)C#CC(=O)N(C)CCNC(=O)[C@H1]1[C@H1]2[C@H1]3C[C@H1]1C(=O)[C@@H1]23 CC1=CC(C(N)=O)=CC(C(=O)N2CC[C@H1](N(C)C(=O)C3=CC=C(Br)O3)C2)=C1 N#CC1=CC=NC(C(=O)N2CC[C@@](NC(=O)[C@@H1]3CSCC(=O)N3)(C4CC4)C2)=C1 CC[C@@H1](C)[C@@H1](C(=O)N=C1C=CN(CCOC)[NH1]1)N(C)C(=O)COC2CCCC2 CC1=NC=C(C(=O)NC[C@H1]2CCC3(CN(C(=O)C4=CC(Cl)=CN=C4O)C3)O2)O1 CCN1C=CN=C1C(=O)N[C@H1]2C[C@H1](O)CN(C(=O)C3=C[NH1]C=C3C(F)(F)F)C2 CS[C@H1]1CN(C(=O)CCCS(=O)(=O)NCC=2C=C[NH1]N=2)[C@@H1](C)C1 C#CC[C@@H1](C(=O)N1CC[C@@](C(=O)NC(C)(C)CC)(C(C)C)C1)C2CC2 CN1CC(CC(=O)N2CCC[C@H1](N(C)C(=O)C=3SC=NC=3C4CC4)CC2)C1 CC(C)C1(CNC(=O)CC[C@@H1]2CCCCN2C(=O)C3CC(F)C3)CC1 CC=1N=C(C2=NC=C[NH1]2)SC=1C(=O)N(CCO)[C@H1]3CCN(C(=O)C(C)C)C3 CC1=C(CC(=O)N[C@@H1]2C[C@@H1]3CC[C@H1](C2)N3C(=O)COC4CC(F)(F)C4)C=NN1C COC(=O)C1=CC(C(=O)N2CCC[C@H1](NC(=O)C[C@@]34CCC[C@H1]3C4)CC2)=NO1 CC1=NC=C([N+1](=O)[O-1])C=C1C(=O)N[C@@](C)(CNC(=O)[C@H1](C)NC(C)(C)C)C2CC2 O=C(C[C@@H1](O)C1CC1)NC[C@@H1]2CN(C(=O)C3=CC4=CC=NC=C4C(O)=N3)CCO2 C[C@@H1](NC(=O)[C@H1]1CC(C2CC2)=NO1)C(C)(C)NC(=O)[C@H1]3C[C@@H1](F)C3 CC1(C)CC(CC(=O)N[C@H1]2COC3(C2)CN(C(=O)[C@]4(C)CCCCO4)C3)C1 COCCC1(C(=O)N2CC=C[C@H1](NC(=O)[C@H1]3CCC4(CCC4)O3)C2)CC1 CN=C1[NH1]C=C(C(=O)N(C)CCCN(C)C(=O)[C@H1](CC(C)C)C(C)C)S1 C#CCN1C=CC=C1C(=O)N2CC[C@](C=C)(C(=O)N3CC4=CC=CC=C4C3)C2 COC1=CC=C(O)C(C(=O)NCCCN(C)C(=O)CC2=CSC(C(C)C)=N2)=C1 CN(C)C1=CC(C(=O)NCC2[C@H1]3CN(C(=O)C=4SN=C(O)C=4Cl)C[C@H1]23)=CC=N1 COC(=O)C1=CC=CC=C1CC(=O)N[C@@H1](C2=CC=C(F)C=C2)C3CCCCC3 CCOC=1SC=CC=1C(=O)N[C@@H1]2CCN(C(=O)C[C@H1](NC(C)=O)C(N)=O)C[C@@H1]2C CC1=CC(F)=CC=C1S(=O)(=O)N2C[C@@H1]3CN(C(=O)CCC=4C=COC=4)C[C@H1]32 CC[C@H1](C)N1N=CC=C1C(=O)NC[C@@H1]2CCC[C@@H1]3CN(C(=O)CC[S@@](C)=O)C[C@@H1]32 CCC[C@@H1](NC(=O)[C@H1]1C[C@@H1]1[C@@H1](C)NC(=O)C2=CC=NN=C2O)C(=O)NC C[C@@H1](CCN(C)C)C(=O)N1CC(OCCNC(=O)[C@H1](NS(C)(=O)=O)C(C)(C)C)C1 CC1=CC(C(F)(F)F)=NC=C1C(=O)N[C@@H1]2C=CCN(C(=O)[C@H1](C#N)C(C)(C)C)C2 CC1=NC(CC(=O)NC[C@@H1]2C[C@@H1](NC(=O)C=3C=NN(C)C=3C#N)C24CCC4)=CO1 O=C(N[C@@H1]1C[C@H1](O)[C@@H1](NC(=O)[C@]2(F)CCOC2)C1)[C@H1]3CCN4C=CN=C4C3 CN(CCCCNC(=O)CN1N=C2C=CC=CN2C1=O)C(=O)[C@@H1]3CCC(=O)O3 CNC(=O)C1=CC=C(CN(C)C2=NC[C@H1](C3=CC(F)=C(F)C(F)=C3)N2C)O1 C[C@@H1]1CCOC[C@@H1]1C(=O)N[C@H1]2CCCC[C@H1]2C(=O)N(C)CC3=CC=NC=N3 CCN1CCN(C(=O)[C@@H1]2C=C[C@@H1](NC(=O)C3=C(C)OC(C)=C3C)C2)CC1=O CC1=CC(OCC(=O)NC[C@@H1](C)NC(=O)[C@@H1]2C[C@H1]3C=C[C@@H1]2C3)=CC=C1F C=C[C@H1](C)NC(=O)[C@]12[C@H1]3C[C@@H1]1[C@H1]4[C@H1](C(=O)NCCN5C=CC=NC5=O)[C@@H1]3[C@H1]42 O=C(N[C@]1(CNC(=O)[C@@H1]2CCCCO2)CCCCC13CCC3)C4=N[NH1]C(O)=N4 NC1=CC(O)=CC(C(=O)N2CC3(C[C@@H1](NC(=O)C4CC5(CC[C@@H1]5O)C4)CO3)C2)=C1 CC1=CSC(CC(=O)N[C@H1]2C[C@@H1](C(=O)NCC[C@@H1]3CC(C)(C)CO3)C2)=C1 CCN(CC(=O)N1CC[C@H1](NC(=O)[C@@H1]2CC2(Cl)Cl)[C@H1]1C(C)C)C3CC3 CC(C)C[C@@H1](NC(=O)CC1CCSCC1)C(=O)NC[C@H1]2CC(C)(C)[C@H1]2O CCC[C@H1](CC)C(=O)NCC1(O)CN(C(=O)[C@H1]2COCCN2C(C)=O)C1 CC=1C=C(C(=O)N[C@H1](C)[C@H1]2CN(C(=O)C3=CN(CC)N=N3)CCO2)N(C(F)F)N=1 CO[C@@H1](C(=O)NCC1=NN=C2N1CCN(C(=O)CCF)C2)C3=CC=CC=C3Cl CC(=O)NCCN(CC12C[C@@H1]3CC(C[C@H1](C3)C1)[C@@H1]2N)C4CCCCCCC4 CCCC[C@H1](NC(=O)C1=CC(C)=NO1)C(=O)N(C)[C@H1](C)CSC CC(=O)N1C[C@H1](O)C[C@@H1]1C(=O)NCC[C@H1]2CCCN2C(=O)CCOCC(F)(F)F FC1=CC=C([C@@]2(F)CCN(C3=NC=NC4=CC=CN=C34)C2)C=C1 O=C(C1=CSC(=NC2CC2)[NH1]1)N3CC[C@H1](CNC(=O)C45CCN(CC4)C5)C36CC6 C[C@@H1]1CN(C(=NCCCN(C)C2CC2)NC(C3CC3)C4CC4)CC(C)(C)O1 CC1=CC=C(CN(C[C@H1](O)CO)C(=O)[C@@H1]2CNC[C@H1]2C(F)(F)F)S1 CC1=NOC(C)=C1CC(=O)NC[C@H1]2CCCCN2C(=O)C(=O)C(F)(F)F CN(C)CC[C@H1](NC(=O)C1=CCSC1)C(=O)N[C@@H1](CO)CCF CCCCN(C[C@H1]1CCC2=CC=CC=C21)C(=O)N[C@@H1]3C[C@H1]3C4=C(F)C=CC=C4Cl CNC(=O)NCCC(=O)NCC1=CC=C([C@H1](C)NC(=O)C=2C=C(F)N(C)N=2)C=C1 C=CC[C@H1](CC(C)C)C(=O)NC[C@@H1](CC)N(C)C(=O)CC1=NON=C1C O=C(C1=C(F)C=NC=C1Cl)N2C[C@@H1]3CN(C(=O)C4(O)CCCCCC4)CC[C@@H1]32 CC(C)C(=O)NC[C@@H1]1C[C@@H1]2COC[C@H1]2N1C(=O)C34CC(C)(C3)OC4(C)C CN1CC[C@]2(CCN2C(=O)[C@H1]3CCO[C@@H1]3CNC(=O)C4=CC=NC=C4F)C1 COC1CC(C(=O)N[C@@H1](C(=O)N[C@H1](C)CCC=2C=N[NH1]C=2)C3(O)CCCCC3)C1 O=C(C[C@@H1]1CCC[C@H1]2C[C@@H1]12)N[C@H1]3COC[C@H1]3C(=O)NCC4=CC=C(F)C=C4 CC(C)(C)C1CCN(C(=O)C2(O)CCN(C(=O)CC3=CC=CC=C3Cl)CC2)CC1 CC[C@H1](C)N1N=C(C(=O)NC2(C)CN(C(=O)C(C)(C)CS(C)(=O)=O)C2)C=C1C CC1=NC(C)=C(C(=O)N[C@H1]2C[C@@](C)(NC(=O)C3=CC=CC=C3N=NN(C)C)C2)S1 CCCC[C@](C)(F)C(=O)NC1CC2(CCN(C(=O)C3=CSC=N3)C2)C1 O=C(NC[C@]1(CO)CCCN(C(=O)C2=CC(Cl)=N[NH1]2)C1)[C@H1]3CCCO3 CC[C@]1(C(=O)N2CCO[C@H1]3[C@H1](O)C[C@H1]32)CCN(C(=O)[C@H1]4C[C@@H1]4C(C)(C)C)C1 CCOCC[C@@H1](NC(=O)[C@H1](CC1CC1)OC)C(=O)N[C@H1]2C[C@H1]3C[C@@H1]2OC(=O)N3 CC=1N=C(C)N(O)C=1C(=O)N2[C@H1]3CC[C@@H1]2C[C@H1]3NC(=O)C=4SC=CC=4C(F)F CC[C@@]1(C)C=C(C(=O)N[C@H1]2C[C@H1](CNC(=O)C[C@H1]3CCNC(=O)C3)C2)C1 O=C(CCCNC(=O)C=1C=CSC=1)N[C@H1]2C[C@@H1](CNC(=O)C=3C=CSN=3)C2 CCN1C=NN=C1C(=O)N[C@H1]2CCN(C(=O)C3(C(F)F)CCOCC3)C[C@H1]2C CN1C=C(C=2C=COC=2C(=O)N3CC[C@@H1](NC(=O)CC4CS(=O)(=O)C4)C3)C=N1 CN1C[C@@H1](C(=O)N2CC3(CC3)C[C@@H1]2CNC(=O)C4=CCOCC4)CC1=O CCC[C@H1](OC)C(=O)N[C@H1](CC(=O)N[C@H1](CC)C(CC)CC)CC(C)C C1N2CC(CN(C(=O)N(C)C3=NC=CS3)C2)OC1=O C[C@H1](CCNC(=O)C1=CC=CC2=C1CCO2)N(C)C(=O)[C@H1]3CCO3 COC1=CC=NC(C(=O)N2CCN(CC=3N=C(C)N4C=3CCCC4)CC2)=C1 COC1(OC)CC(C(=O)N[C@H1]2CC[C@H1](CNC(=O)C3(C(F)F)CCC3)CC2)C1 COC[C@@H1](C)C(=O)N(C)C[C@@H1]1CCCN1C(=O)C(C)(C)CC(F)F CC1=CC(C)=NC(C2CN(C(=O)N[C@H1](C)[C@@H1]3CN(C)CCO3)C2)=N1 C#CC[C@H1](C)C(=O)N[C@@]12CC[C@@H1](C1)N(C(=O)CC(C3CC3)C4CC4)C2 CCC1=CC(Br)=CC=C1CN2CCOC[C@H1]2CC(=O)N3CCN(C)C(C)(C)C3 CSCC1(CNC(=O)OC(C)(C)C)C=C[NH1]C1C(=O)N[C@@H1]2C[C@H1]3[C@@H1](C2)C3(F)F C[C@@H1]1C[C@H1]1CN=C(C2=CSC(C3=CC=C(Cl)C=C3)=C2)N(C4=CC(Cl)=CC=C4O)N CCC(F)(F)CC(=O)N1CC2(CCC2)C[C@H1]1CNC(=O)C3(F)CCC3 CC[C@@H1]1CCO[C@@H1]1C(=O)N2C[C@H1]3CN(C(=O)C4=CC(COC)=CS4)CC[C@H1]32 CN1C(=O)CC2=C(C(=O)N3CCOC[C@H1](NC(=O)[C@]4(C)C=CCC4)C3)C=CC=C21 CC[C@@H1](CC(=O)N[C@@H1](CC=1C=C[NH1]N=1)C(=O)NCC2(C)CC3(CC3)C2)C4CCC4 CC1=C([N+1](=O)[O-1])C=CCC2=C(C(=O)N3CCOC[C@@H1](C=4N=N[NH1]N=4)C3)[NH1]C12 CNC(=O)CC(=O)N1C[C@@H1]2CCC[C@H1](C1)N2C(=O)[C@@H1]3C[C@H1]4C[C@H1]3[C@@H1]5[C@H1]4C5(F)F CCC(=O)NCC(=O)N[C@H1](CNC(=O)C1=CSC(C)=C1C)[C@@H1]2CCOC2 C#CCNC(=O)CC(=O)N1C[C@@H1]2CC[C@H1](C1)N2C(=O)C3=CC(OC)=CN=N3 C[C@H1](NC(=O)CSC1=CC=CS1)[C@@H1]2CCCCN2C(=O)C#CC(=O)N(C)C C=CC[C@H1](C(=O)N[C@H1]1CN(C(=O)CC2(C(F)(F)F)CC2)C[C@@H1]1C)C(C)C COC(=O)C12CCC(C(=O)N[C@@H1](C)[C@@H1]3CCN(C(=O)CCCSC)C3)(CC1)C2 C=C=C(C)CC(=O)N[C@H1](C)CC1C[C@@H1]2CC[C@H1](C1)N2C(=O)[C@](C)(O)COC CC(C)C[C@H1](O)[C@H1](C)C(=O)NCC(=O)NCC(=O)N1C[C@@H1](C)[C@@H1](N(C)C)C1 COC[C@H1]1CC[C@@H1]1C(=O)NC[C@@H1]2C[C@H1](F)CN2C(=O)C3=CC=C4C(=C3)CC(=O)N4 COCC(=O)NCCC(=O)N(C)C[C@H1]1CCCN1C(=O)C=2[NH1]N=NC=2C(F)F C[C@H1]1CN(C(=O)C2=CC=CC3=CC=CN23)C[C@@H1]1C(=O)NCC4=NOC(C(N)=O)=N4 CC1=CC=NC(O)=C1C(=O)N[C@H1]2COCCN(C(=O)C3=CC=C(Br)C=N3)C2 CC1=NN(C)C(C)=C1CN2CC(CC(=O)NC3=CN=C(N(C)C)C(Br)=C3)C2 CC(C)N(CCN(C)C(=O)[C@@H1]1CCO[C@H1]1C2CC2)C(=O)CC=3C=CSN=3 COC(=O)[C@@H1]1C[C@H1](NC(=O)OC(C)(C)C)CN(C(=O)C2=CC=NC(C)=C2)C1 COCC(=O)N(C)[C@@H1]1CCCC[C@@H1]1NC(=O)C2=CSC(C(F)F)=N2 CC1=CN=C(C(=O)N2CC[C@H1](NC(=O)CN(C)[C@@H1]3CCSC3)C[C@@H1]2C)C=N1 CCC=1OC=CC=1C(=O)N2C[C@H1](C)[C@@](C)(C(=O)N[C@H1](C)C3=NC=C(C)S3)C2 C[C@@H1](CCNC(=O)C=1N=C(Cl)C(=O)[NH1]C=1N)NC(=O)C2(C3=NC=CS3)CC2 O=C(N[C@@H1]1C[C@H1](O)[C@H1](O)C1)[C@@H1]2C[C@@H1]3CCC[C@@H1]3N2C(=O)[C@H1]4CCCO4 CC(C)(C)OC(=O)NC[C@@H1]1C[C@H1](C(=O)NC[C@H1](F)C2=CC=CC(Br)=C2)S1(=O)=O C[C@H1](NC(=O)C1CCCC1)C(=O)NC[C@@H1](C)NC(=O)C2=NOC3=C2COCC3 CC=1SC(Br)=NC=1CN=C2[NH1]C3=C(C(=N[C@@H1]4CCOC5=CC=CC=C54)[NH1]2)CSC3 CCC1(NS(=O)(=O)C2=CN=C(N[C@H1]3COC4(CCC4)C3)C=C2C)CCCC1 C#CC1(O)CC(C(=O)N2C[C@@H1]3C[C@H1](C2)CN3C(=O)[C@@H1]4CCC[C@@H1]4O)C1 CC1=CC(CCC(=O)NC[C@@H1](F)C2CCN(C(=O)[C@]3(O)CC3(C)C)CC2)=N[NH1]1 C[C@H1]1CO[C@H1](C(=O)N[C@@H1]2C[C@H1]3CC[C@H1]2N(C(=O)C4CC(F)(F)C4)C3)C1 CC1=CC=CC(C(=O)NC2=CC=CC(NC3=CC=NC4=NC=NN34)=C2)=C1F CC1=CC=CC=C1C(=O)N[C@H1](C(=O)N(C)[C@H1](CO)C2CC2)[C@H1]3CCOC3 CC1=CC(C)=C(C(=O)N2CCO[C@@H1](C(=O)NCC3=CC=CC(N)=C3F)C2)C(Cl)=N1 C=C[C@@H1]1COC[C@H1]1NC(=O)C[C@@H1]2CCN2C(=O)CCC3=CN=CO3 CC1=CON=C1C(=O)NC[C@@H1](CC(C)C)NC(=O)C2=C(Cl)CC2 C[C@@H1]1CN(C(=O)C(F)(F)C(F)F)CC[C@@H1]1CNC(=O)[C@H1]2CCC3=NN=C(O)N3C2 C=CC1(CC(=O)N[C@H1]2CN3CCC2(C)CC3)CN(C(=O)C4=CN=C(NC)C=N4)C1 CC[C@H1]1CN(C(=O)C2(CC)CN(C(=O)C3=CC=CC4=CC=NN34)C2)C[C@@H1](C)O1 CC1(C)CN(C(=O)C2=CC=CC3=NC=NN23)CC[C@@H1]1NC(=O)[C@@H1](F)N4C=CC=N4 N=C1N=C(O)C=2N=CN(CC(=O)OCC3=CC=CC(Cl)=C3F)C=2[NH1]1 COCCCNC(=NCC[C@H1](C)N1CCCCC1)N[C@H1](C)C2=CSN=N2 CC[C@@H1](C)CC(=O)C(=O)NN1CCC[C@H1]1C(=O)NC[C@@H1]2CCO[C@H1]2C CCCCCCNC(=O)[C@H1](C1=CSC(C2CC2)=C1)N(CC)C[C@@H1]3COCCO3 CC(C)(C)CCCC(=O)NC[C@H1](NC(=O)CN1N=C(O)C=CC1=O)C2CC2 O=C(CC1=CN=C[NH1]1)N2CCN(C(=O)C3=CC=NC=4C=CSC3=4)[C@@H1](C5CCC5)C2 C#CCNC(=O)CN1C[C@H1]2CC[C@H1]1CN2C(=O)CSCC=3C(C)=NOC=3C CC1=CC=NC2=C(C(=O)NCC#CCNC(=O)[C@@H1]3C[C@@]3(F)Cl)C=CC=C12 C[C@@H1]1C[C@H1](NC(=O)C=2C=CC3=NON=C3C=2)CN1C(=O)CCC=4N=C[NH1]N=4 CCOCCO[C@@H1](C)C(=O)N1CC(NC(=O)C2=CN=C3N2CCC[C@H1]3C)C1 CCN1C=C(C(=O)NC2CC3(C2)C[C@H1]3NC(=O)CCC=4C=CON=4)C=N1 COCCO[C@H1]1COCC[C@H1]1NCC2=CN(C3=CC=C(C#N)C=C3Cl)N=N2 CCC(C)(C)[C@@H1](O)C(=O)N1CC2(CNC(=O)C3=CN=C4N3CCS4)CCC1CC2 CC1=CC=CC(Cl)=C1CC(=O)N[C@H1](C)C(C)(C)NC(=O)C=2C=C(C(C)C)ON=2 C[C@@]1(CCNC(=O)C=2[NH1]N=C([N+1](=O)[O-1])C=2Cl)CCN(C(=O)C3(C#N)CCC3)C1 CC1=CC=CC([N+1](=O)[O-1])=C1N2CCC[C@@H1](NC(=O)[C@@]3(O)CCC[C@H1](C)CC3)CC2 COC1=CC=C(C(=O)N2CC[C@H1](CNC(=O)C3(C(=O)N(C)C)CC3)C[C@H1](O)C2)O1 CCSC1(C(=O)N[C@H1]2C[C@H1](CNC(=O)C(C)(C)CS(C)(=O)=O)C2)CC1 CC(C)C1=NN=C(CN=C2C=CN=C(NCC(C)(C)F)[NH1]2)S1 CC(C)(C(=O)N1CCC(NC(=O)[C@]23C[C@H1]2COC3(C)C)CC1)C4=CC=NS4 O=C(CC1=CN=CS1)NCC2(CNC(=O)C=3C=CC4=NON=C4C=3)CCCC2 COC1=CC=CC(C(=O)N[C@@H1]2CN(C(=O)C3=CC(F)=C(C)C=C3F)CC2(F)F)=C1 CC(C)N(C)C[C@H1](C)NC(=O)C1=CC=C(CNC(=O)C[C@H1]2CCC(=O)N2)C=C1 CCC[C@@H1](O)CC(=O)NCC[C@@H1]1CCCN1C(=O)C2=CC=NC(F)=C2N NC=1SN=NC=1C(=O)N2CC[C@@H1](C(=O)NCC[C@H1]3CC=CCC3)C2 CNC=C([C@H1]1OCC[C@@H1]1[C@H1](NCC(C)(C)C(F)F)C2=NN=NN2C3CC(F)(F)C3)C=N C[C@H1](CCNC(=O)[C@]1(C)C[C@@]1(F)Cl)NC(=O)C(C)(C)OC2=CC=CC(Cl)=C2 CC(=O)C(=O)NC[C@H1]1CN(C)CCN1C(=O)C2=CC(C)=C3[NH1]C=NC3=C2 CCCC1=CC=C(C(=O)N2CCC3(CCC[C@@H1]3NC(=O)C4=NOC=C4Cl)CC2)S1 C[C@@H1](CN1CC[C@@H1](C2=CC=CC(Cl)=C2)O[C@H1](C)C1)C(C)(C)C CC[C@@H1](CC(=O)NC1CN(C(=O)CCOC)[C@H1](C2=NC=CN2C)C1)CC(F)(F)F CCOCCNC(=O)[C@H1](C1=CC=C2C=C(Br)C=CC2=C1)N3CC[S@](=O)C[C@H1]3C CCCN1C(=O)CC[C@@H1]1C(=O)N(C)CCNC(=O)C(=O)C2=CC=C(Cl)S2 CCN1C=CC=C1C(=O)N[C@H1]2CCN(C(=O)[C@H1](C)C3CCC3)CC24CCC4 COC1=CC=C2C=C(CN3CCN(CC(=O)OC(C)(C)C)CC3)C=CC2=C1 CC1=NOC(CNC(=O)[C@H1](COC(C)C)NC(=O)C=CC2CC2)=N1 COC1=CC=CC2=C1[C@H1](C(=O)N3CC[C@@H1](C4=CC=C(O)C=C4)C3)CC2=O CC[C@@H1](C)CCCCC(=O)NCCNC(=O)C1=CC(=O)N(C)C2=CC=CC=C12 COCC(COC)C(=O)N[C@H1](C)[C@@H1]1CN(C(=O)C2=NON=C2N)CCO1 CSC1=NC=C(C(=O)N2C[C@H1](O)C[C@H1]2CNC(=O)C3=CC(F)=CC(Cl)=C3)C(O)=N1 O=CCNC(=NCC1CCC1)NCCC2C3OCC(COC2)O3 C=C(F)C(=O)N1C[C@H1]2CC[C@H1]1CN(C(=O)[C@H1](C)C3=CC=C(OC)C=C3)C2 CC(C)C1(C(=O)NC[C@@H1](C)CNC(=O)C2=CC3=NC(Cl)=CC=C3S2)CC1 CC=1C=C(CC(=O)N[C@H1]2CCSC23CN(C(=O)[C@@H1]4C[C@@H1]5CC[C@@H1]5C4)C3)ON=1 CC(C)(C)C(=O)NC1=CC=C(C(=O)CN[C@@H1]2CCC3=CC(Br)=CN=C32)C=C1 CCCCC[C@H1](O)[C@H1](C)C(=O)N1CC[C@H1](N(C)C(=O)CN(C)CCCCCC)C1 COC1=NC(C(=O)N(C)[C@H1]2CN(C(=O)C=3N=CN(C)N=3)CC2(C)C)=NC=C1F CC(C)SCC(=O)N(C)[C@@H1]1CC[C@@H1]2CN(C(=O)C3CC4(C3)OCCO4)C[C@@H1]21 COCCC1(C(=O)N2C[C@@H1](C)[C@H1](CN=C3[NH1]N=CO3)C2)CCCC1 CN1N=CC=C1[C@@H1](NC(=O)C2=CC=NC=C2N)C(=O)N[C@H1](C(N)=O)C3CCCC3 CC1=NC(C)=C(C(=O)N(C)CCCCN(C)C(=O)[C@@H1]2CCC=3SC=NC=32)N=C1C C=C[C@H1](CC(=O)OCC)OC(=O)C1=C(F)C=C(Br)C=C1F CC=1C(C(=O)N[C@H1]2CC=C(C(=O)N3CCCCC3)C2)=C(C)N4C=CN=CC=14 COC1=NSC=C1C(=O)NC[C@@H1]2C[C@H1](NC(=O)C3=CC=C([C@H1](C)F)C=C3)C2(C)C C=C[C@@H1](C)CC(=O)NC1CC2(C1)C[C@H1]2NC(=O)C=3N=NN(C(C)(C)C)N=3 CC(C(=O)N[C@@H1]1CCN(C(=O)COC2=CC=C(C)C(C)=C2)C[C@@H1]1C)=C3CCCC3 CCN1C(=O)CC[C@@H1]1C(=O)N[C@H1](C)C2(O)CCN(C(=O)[C@@](C)(O)C(F)(F)F)CC2 C[C@H1](CC(=O)NCCC[C@H1](O)CO)N(C)C(=O)CN1CCOCC1 CC1=CC=CC(C)=C1OCC(=O)N[C@H1]2C[C@H1]2NC(=O)[C@@H1]3OCCC4=CC=CC=C43 C[C@@H1]1CCN(C(=O)C=CC2=CN=CC=N2)C[C@@H1]1NC(=O)[C@H1]3CC[C@H1]4CCCCN43 COC1(C(=O)N(C)CC2=CSC(N)=N2)CN(C(=O)[C@@H1]3CC4(CCC4)CO3)C1 C#CCCOCC(=O)NC[C@@H1](CCOC)NC(=O)C1=N[NH1]C=C1OC C[C@H1](CCC1=CC=CC(F)=C1)C(=O)NC[C@]23C[C@@H1](CO2)N(C(=O)C4(C)CCC4)C3 C/C=C/C[C@H1](C)C(=O)NC[C@@H1]1CN(C(=O)C2=CC=NN2COC)CCC1(F)F O=C(CC1=CN=NS1)N2CC[C@@](CO)(C(=O)NN3C=NC4=CC=CC=C43)C2 CN1C(=O)CCC[C@@H1]1C(=O)N2CCC[C@H1]2C3(NC(=O)CC[C@H1]4CC4(Cl)Cl)CC3 C=CC[C@@H1](CNC(=O)CN1C=C(Cl)C=N1)C(=O)NC[C@H1]2CC(C)=NO2 CC(C)CCO[C@H1](C)C(=O)N1CC=C[C@]1(C)C(=O)N2C[C@@H1]3C[C@H1]2C[S@@]3=O CCOC(=O)C1(CNC(=O)[C@H1]([C@@H1]2C[C@H1]3CC[C@H1]2C3)N(C)C[C@H1]4CCCCO4)CC1 COC1=CC=C(C(=O)N2C[C@H1](CO)C3(CN(C(=O)CSC(F)(F)F)C3)C2)C(C)=N1 CC[C@@H1](CN(C)C(=O)C=1C=CON=1)NC(=O)C2CC3(C2)CC(OC)(OC)C3 O=C(N[C@H1]1CN(C(=O)C=CC2=COC=N2)C3(CCC3)C1)C=4C=C(CCO)ON=4 COCC1(NC(=O)C2CC3(CCN(C(=O)C45CCC(CC4)C5)C3)C2F)CC1 CCS[C@@H1]1CC[C@@H1](NCC=2N=COC=2C(C)C)C1 CC(=O)N1CC(C(=O)N2CCN(C(=O)C3=COC(Cl)=N3)[C@H1](C4=CC=CC=N4)C2)C1 CCN(C(=O)[C@](C)(C1CC1)N(C)C(=O)[C@H1]2SCC=C2C)[C@@H1](C)C3CCC3 C#CCCC(=O)N1CC[C@H1](C)[C@H1](NC(=O)C(F)(F)C2=CC=C(OC)C=C2)C1 CO[C@H1](CNC(=O)CC1=NSC2=CC=CC=C12)CNC(=O)C3=C[NH1]N=C3C(F)F CC(=O)C1=CC=C(S(=O)(=O)N[C@@H1](C)CC2=C[NH1]C3=CC(F)=CC=C23)C=C1F N=C1[NH1]C2=C(S1)CCC[C@@H1]2NC[C@@]34CC[C@@H1](CO3)C4 C#CCC(C)(C)C(=O)N[C@H1]1CCC[C@@H1]1CNC(=O)/C=C/C=2C=COC=2 CCN1C=C(C#N)C(=NC(=O)[C@H1]2C[C@@H1](O)CN2C(=O)CCC=3C(C)=NOC=3C)[NH1]1 CCC=1N=NSC=1C(=O)N2CC[C@@H1]3C[C@]3(C(=O)N4C[C@@](C)(O)CO4)CC2 O=C(N1[C@H1](CNC(=O)[C@H1]2C[C@H1](O)C2)C[C@@H1]3CCC[C@@H1]31)C4C[C@@H1]5COC[C@H1]5C4 O=C(NC[C@H1]1CCCN1C(=O)CC2=CC=C(F)C=C2F)[C@@H1]3CC4(CCC4)CCO3 CC1=CC=NC=C1C(=O)N(C)C2CN(C(=O)[C@]3(C4=CC=CC=C4)CCN(C)C3)C2 COCC[C@H1](C)C(=O)N[C@@H1](CCN(C)C(=O)C=1SC=CC=1C(C)(C)C)C(C)C CC1=CC(CNC(=O)[C@@H1]2C[C@@H1](F)CN2CC3=CC=C4C(C=NN4C)=C3)=NO1 CC(C)C[C@H1](O)[C@H1](C)C(=O)N1CC2(C[C@H1](C(=O)N[C@H1]3CCC(C)(C)C3)CO2)C1 CC=C[C@H1](O)C(=O)N1CCC([C@@H1]2CCCN2C(=O)C=3SC=NC=3COC)CC1 O=C(N[C@H1]1CC[C@H1](OC2=NC=CC=C2Cl)CC1)C=3OC=CC=3I CC[C@@H1]1CC[C@H1](C(=O)NC2CN(C(=O)C=3C=NN([C@@H1](C)C(C)C)C=3C)C2)O1 COC(=O)CC(=O)N1C[C@@H1](C)C[C@@H1](NC(=O)C2=COC(CC3CC3)=N2)C1 O=CN(CC1=CC=C(C2CC2)C=C1F)CC3=CN=C(COC4=CC=CC=C4)S3 CC[C@H1](C)C(=O)C(=O)N1CCC[C@H1](C)[C@H1]1CNC(=O)C23CCN(CC2)C3 COC1=CC(F)=CC(CC(=O)NC2(CCNC(=O)C3CCSCC3)CC2)=C1 COCC1(NC(=O)[C@@H1](F)OC)CCN(C(=O)CC2=C[NH1]C3=CC=C(Cl)C=C23)CC1 C[C@@H1]1C(=O)C[C@@H1]1C(=O)N2CCC[C@@H1](CCCCNC(=O)C=3OC=C4C=3CCC4)C2 CN(CCCCCCNC(=O)C1=CN=NS1)C(=O)[C@H1]2[C@@H1](C(F)F)[C@H1]3CC[C@H1]2C3 CO[C@@H1](CSC)C(=O)NCC1(O)CCN(C(=O)C2=CN=C3[NH1]C(C)=NC3=C2)CC1 C=CCN=C(NCC[C@@]1(O)CCOC1)NCC2=COC(C)=C2 C[C@H1](C(=O)NCCCOCCNC(=O)[C@H1]1CCSC1)N2C=NC3=CC=CC=C32 CC1=N[NH1]C=C1C(=O)N[C@H1](CC=2C=N[NH1]C=2)C(=O)N3CC[C@H1]3C(=O)N(C)C CN1C(C(=O)NCC2(C#N)CCCC2)=C(Br)C3=CC=CC=C31 CCCN(C(=O)C=C(C)C)C1CCN(C(=O)C2=CC=C(OC)C(OC)=C2C)CC1 C#CC1(C(=O)NCCN(C[C@@H1](C)O)C(=O)C=2SC=C(Cl)C=2Cl)CCOCC1 CNC(=O)CCN1C=C([C@]2(C)COCCN2C(=O)C[C@@H1](C)COC)N=N1 CCN1C[C@H1](C(=O)NC[C@@H1](N=C2C=CN=C(Cl)[NH1]2)C(C)C)CC1=O CC1=CC=C2SC(C(=O)N[C@H1]3CN(C(=O)C=4SC=CC=4C)[C@@](C)(CC)C3)=CC2=C1 CC[C@@H1](OC1CCCC1)C(=O)NC[C@H1](NC(=O)CCCC#N)C(C)C COC(=O)[C@@H1]1CCN(C(=O)CN2CCN(C(=O)[C@@H1](C)N=[N+1]=[N-1])CC2)[C@@H1]1C CC=1N=NSC=1C(=O)N2CC[C@@H1](C(=O)NC3CC(=O)NC(=O)C3)C24CC4 O=C(NC[C@@H1](O)C1NCC=2OC=CC=21)[C@H1]3CC[C@H1]3C4=CC=C(F)C=C4 CC[C@@H1](CNC(=O)[C@@H1]1C[C@@H1]2CCC[C@@H1]2N1C(=O)[C@H1](C)[C@@H1](O)C(C)C)OC N#CC=1SC=CC=1C(=O)N[C@H1](CO)CNC(=O)CCOC2=CC(Cl)=CC(Cl)=C2 CN1C=C2C(=N1)CN(C(=O)[C@H1](F)[C@@H1]3CCN(C(=O)C4(C#N)CC(=O)C4)C3)CC2 CO[C@@H1](C)C(=O)NC[C@@H1]1CCC(C)(C)CN1C(=O)C2=CC3=C(O)N=CN=C3C=N2 CCC=1N=C(C)OC=1C(=O)N[C@@H1](CC)CCC(=O)N[C@@H1](C)C=2N=CN(C)N=2 CC(C)(C)[C@@H1](CO)C(=O)NCC1=CN(CCNC(=O)CC2CC3(CC3)C2)N=N1 CC(=O)C1=CC=C(F)C=C1C(=O)N[C@H1](C2=CC=CC=C2)C3CC3 C[C@@H1](NC(=O)CC1=CN=C2N1CCOC2)[C@@H1]3CCCCN3C(=O)CS(C)(=O)=O C[C@@](O)(CCO)CNC(=O)[C@]12CO[C@H1](C1)[C@H1](NC(=O)[C@@H1]3C[C@@H1]4CC[C@@H1]4C3)C2 CCC[C@H1](O)CNC(=O)CCCN(C)C(=O)[C@@H1]1CCO[C@@H1]1CC COCCN(C)CC(=O)N[C@@H1]1C[C@@H1](CNC(=O)C2(O)CCCCCC2)C1(C)C C[C@@H1]1C[C@H1](C(=O)NCCCN2C=NN=C2)N1C(=O)C[C@@H1]3CCC[C@H1]4C[C@@H1]34 O=C(C[C@@H1]1C[C@@H1]2CC[C@H1]1C2)N3CC[C@@H1]4CN(CC5=CC(I)=CC=C5F)C[C@H1]43 CCCC1=NN=C(S)N1CC(=O)NC[C@H1]2C[C@](F)(CNC(=O)[C@@H1](O)CSC)C2 CC(C)[C@@H1](C(=O)NC[C@@]12C[C@@H1](CO1)N(C(=O)C3=CC=C(C(N)=O)[NH1]3)C2)N(C)C COC(=O)C1=CN=C(N2CC[C@@H1](CNC(=O)C3=CC=CC=4N=C(C)[NH1]C3=4)C2)N=C1 CCSCC1=CC(C(=O)N2CCC([C@@H1](C)CNC(=O)[C@@H1](C)CSC)CC2)=NO1 CC[C@@](C)(NC(=O)C(=O)N1CCC[C@](C)(OC)C1)C2=NC(C)=CS2 CCOCC(C)(C)NC(=O)C1CC(CCNC(=O)C2=CC(OC)=NN2C)C1 CCC1=CC=C(C=CC(=O)N(C)[C@@H1](C)CCNC(=O)C2CC3(CC(O)C3)C2)C=C1 C[C@H1](C(=O)NC1(C2CN(C(=O)[C@@H1](F)C(F)(F)F)C2)CC1)N3C=CC(C(F)(F)F)=N3 CCSCCCNC(=O)[C@H1](CSC1=CC=C(F)C=C1)N2CCCCCCC2 COC1(CC(=O)NC[C@H1]2CCN2C(=O)C3=C(C)N=CN3C)CCC1 CCCS(=O)(=O)N[C@@H1](C)C(=O)N1CCCC[C@H1]1CCNC(=O)CCC(C)(C)F C[C@H1]1[C@@H1](C)[C@@H1]1C(=O)N(C)C[C@H1](O)CN(C)C(=O)CCOC2=CC=CN=C2 CCN(CCNC(=O)C1=CC=CC2=C1OC(C)(C)CC2)C(=O)C3(C4CCC4)CC3 CC(CO)CN(C)C(=O)[C@H1]1C[C@@]12CCNC2 COCCCNC(=O)[C@H1](C1=C(I)N=CN1C)N(C)C2CCC(OC)CC2 ClC1=CC=C2C(NCC3=CN=C(C4=CC=CS4)S3)=CC=NC2=C1 O=C(N[C@H1]1C[C@H1]2C[C@@H1](C1)N(C(=O)CC3=CC=CN=C3Cl)C2)C4=C(Cl)CCCC4 CCC[C@@H1](OC)C(=O)N[C@H1]1C[C@H1]2C[C@@H1](NC(=O)C=CC3=CC=NN3C)[C@@H1]1C2 CC1=CN2C=C(C(=O)N[C@@H1]3C[C@H1]4C[C@H1]3CN(C(=O)C5CCCCC5)C4)SC2=N1 C=C[C@@H1](C)CC(=O)N[C@H1](CO)CNC(=O)C1=CC=C(F)C(CN(C)C)=C1 C[C@H1](CNC(=O)C(C)(C)NC1=CC=CC=C1)N(C)C(=O)[C@@H1](C)CF COC(C)(C)C[C@H1](C)NC(=O)[C@@H1](CCF)NC(=O)C1C[C@H1]2CC[C@H1](C1)C2 CC1=CC=C(C(=O)N[C@@]2(C3CC3)CCN(C(=O)C4CC(Cl)(Cl)C4)C2)C=N1 CC(C)(CN[C@H1](CCCO)C1=NN=NN1CC2CC2)C3=CC=C(F)C=C3Cl C[C@@H1](CC(=O)N[C@H1]1CCN(C(=O)CCC2=CC=C(Cl)S2)CC1(C)C)C3CC3 O=C(CCCC(=O)C1CC1)NC[C@@H1]2CC[C@H1](NC(=O)CCCCC3CC3)C2 C[C@@H1]1[C@@H1](N(C)C(=O)[C@@H1]2CC23CCN(C(=O)[C@H1]4CC(=O)N(C)C4)CC3)CCC[C@H1]1C CCOCC(=O)N[C@H1]1CC[C@@H1](C)N(C(=O)C2=CSC(=NC)[NH1]2)C1 CC(=O)C1=CC=C(C(=O)N2CC=C(CNC(=O)[C@@H1]3CC(C)(C)CO3)CC2)C=C1 CCCCCC(CCCCC)CC(=O)N1CC[C@@H1](CN(C)C(=O)[C@H1](C)OCC)C1 CC(C)(CCF)C(=O)NCCCC(=O)NOCCF CC1=CC=C(C(=O)NC[C@@H1]2CCC[C@H1]2NC(=O)[C@H1]3C[C@@H1](O)C3)C=C1CO CC1=CC=C(C(=O)N=C2[NH1][NH1]C=C2CN(C)C)C=C1S(=O)(=O)NC(C)C C=CCCCC(=O)N1CCC[C@]2(NC(=O)CCCN3C(O)=NN=C3O)CCC[C@@H1]12 N#CC1(CC(=O)NC2(CNC(=O)[C@H1]3C[C@@H1]4CC[C@H1](C3)O4)CC2)CC1 COC1=CC=C(C(=O)N2C[C@@H1](NCC3=CC=C(O)C(C)=C3O)C4(CC4)C2)C(Br)=C1 C=CC=CCC(=O)N[C@@H1](C)[C@H1](C)NC(=O)C1=CC=C2C(Br)=CN=CC2=C1 CC(C)C(=O)NC1=CC=C(C=2N=C(C3CC=CC3)N(C45CC(C4)C5)N=2)C=C1 CC1=CC(O)=NC(C(=O)N[C@@H1]2CO[C@@]3(CCCN(C(=O)C=4C=CSC=4)C3)C2)=C1 CN(C[C@@H1]1CCN(C(=O)C2=CN=CC(F)=C2Cl)C1)C(=O)[C@H1](F)CC3CCC3 CSC1=NC(C)=CC(=NC[C@@H1]2CN(C(=O)CCC3=NC(C)=C(C)O3)C[C@H1]2C)[NH1]1 C#CCCCOCC(=O)N1C[C@@H1]2C[C@H1]1CN2C(=O)C3=CC=C(F)C=C3OC COC1=CSC=C1CN2C(=O)CN(CCNC(=O)C3=CC=C4C=CC=CC4=N3)C2 CCO[C@@H1]1C[C@H1]1C(=O)NCC[C@@H1]2CCCN(C(=O)C=3C=C(C)N(C4CC4)C=3C)C2 COC1=CC=CC(N2CCC[C@H1](C(=O)N3CC[C@@H1](C4=CC=CC=C4)C[C@@H1]3C)C2)=N1 C[C@](O)(CNC(=O)[C@]1(C)CCCN(CC2=NOC(C3CC3)=N2)C1=O)C4=CC=CS4 CCN(C[C@@H1](C)NC(=O)CC1=CC=CC(C(C)C)=C1)C(=O)CCC2=CN=C(O)[NH1]2 C[C@@H1](CCN(C)C(=O)C1=CC=C2C(C#N)=C[NH1]C2=C1)NC(=O)[C@@H1]3[C@H1]4COC[C@H1]43 CC=1N=C[NH1]C=1CN2C[C@H1]3CCC[C@@H1](CNC(=O)CN4C=CC=CC4=O)[C@H1]3C2 C[C@@H1](CC1CCC1)C(=O)NC23CC(CNC(=O)C4=CC=NC5=C4C=CN5C)(C2)C3 C[C@@H1](NC(=O)[C@@H1]1CCCC2(CCC2)C1)[C@@H1](CO)NC(=O)C=3C=C4N(N=3)CCC4 CCN1CCN(CC(=O)N[C@@H1]2CCCC23CN(C(=O)C4=N[NH1]C=C4F)C3)CC1 CC(C)(C)OC(=O)NC[C@](C)(O)CNC(=O)[C@H1]1C[C@@H1](NC(=O)C(F)(F)F)C1 CCOC1(CNC(=NCC2CC2)N3C[C@@H1](O)C(C)(C)C3)CCCCCC1 O=C(C1=CC=C(O)C(Br)=C1)N2C[C@H1](NCC3=CC=CC(Cl)=N3)C4(CC4)C2 CC(=CC1CCCC1)C(=O)N2CCCN(C(=O)[C@@]3(C)CCCNC3=O)C[C@@H1]2C CCN(C[C@H1](C)C#N)C(=O)[C@H1]1CCCCN(C(=O)C=2C=CN(C(C)C)N=2)C1 COC(=O)NCCCC(=O)NC[C@H1]1CN(C(=O)C2(C)CC=CC2)C[C@@H1]1C CC(C)C[C@@H1](N[C@@](C)(CC1CC1)C2=NN=NN2CC3CC3)C(=O)N(C)C CC[C@H1](C)C(=O)NCC(=O)N1C[C@@H1]2CCCN(C(=O)C(=O)NCCOC)[C@@H1]2C1 C=C(C)C[C@@H1](OC)C(=O)NCC[C@@](C)(CC)NC(=O)[C@H1]1C[C@@H1]2CC[C@H1](C1)O2 C[C@@H1](CNC1=CC=C(OC2=CC=CN=C2)C=C1)CN3CCCC3 C[C@@H1](CCNC(=O)C1=CC=CC(C(C)(F)F)=C1)N(C)C(=O)CCC#N CN(C)CCOCCC(=O)N1C[C@@]2(NC(=O)C3=CC=C(Cl)C(C#N)=C3)CC[C@H1]1C2 COCCNC(=O)[C@@H1]1CCO[C@H1]1CNC(=O)C2=CC=C3C=CC=NN23 CC[C@H1](C)C=1C=C(C(=O)N2CCN(C(=O)C=3[NH1]N=NC=3C4CC4)CC[C@H1]2C)ON=1 C=C[C@](C)(O)CC(=O)NCCCC1=CC=C(O)C=C1 O=C(CC[C@@H1]1CCCN(C(=O)COCCF)C1)NCC=2C=CSC=2 CC[C@@H1]1CCC[C@H1]1C(=O)N[C@@H1](C)CN(C)C2=NN=NN2C3=CC=C(C(C)C)C=C3 CC1=C(F)C=CC=2[NH1]C(C(=O)N3C[C@H1]4CN(C(=O)C5(C#N)CC5)C[C@@]4(C)C3)=CC1=2 CC1=CC(CC(=O)N[C@H1](C)[C@H1](C)C(=O)N[C@]2(C)CCCCC2(C)C)=NO1 CCC[C@@H1](C#N)C(=O)N(C)[C@H1](C)CCNC(=O)C1=CSC=C1C COC1=C(C(=O)N2CC[C@@]3(NC(=O)C4=CC(C)=NS4)CCC[C@H1]23)C=CN=C1F C[C@@H1](C(=O)N1CC(N(C)C(=O)CC2=C(O)N=CN=C2O)C1)N3CCC[C@H1](O)C3 CC[C@H1](O)CC(=O)NC[C@@H1]1C[C@]2(CCN(C(=O)CC3=NC(C4CC4)=N[NH1]3)C2)CO1 COC[C@H1](OC)C(=O)NCC[C@@H1](O)CNC(=O)C=1C=CN2C=1CCCC2 C#CCCC(=O)N1CCOC[C@H1]1CC(=O)NC[C@H1]2C[C@H1]2C(=O)OC CC(C)[C@@H1](CNC(=O)/C=C/C1=CC=CC=C1)NC(=O)[C@@H1]2CC3=CC=C(F)C=C3O2 CCCSCCC(=O)NC12CCC(C(=O)N3CC[C@@H1](C)C[C@H1]3C)(CC1)C2 C=C(C)CC(=O)N1CCC2(CC[C@H1](CNC(=O)[C@H1](C)C3=CC=CC=N3)OC2)CC1 COC(=O)[C@]1(NC(C)C(=O)N=C2C=CC3=CC=CC=C3[NH1]2)CCSC1 CC1=CC(NC[C@H1]2CN(C(=O)C3(C)CCC3)CC2(C)C)=NC(C4=CC=CN=C4)=N1 C[C@H1](C(=O)N[C@]1(CF)CCN(C(=O)[C@H1]2CN3CCC2CC3)C1)C4=CC=CS4 CCOCCCC(=O)N1CCC[C@@](O)(CN2C=C(C[C@@]3(O)CCSC3)N=N2)CC1 O=C(C=C1CCOCC1)NCC2=NC(C(=O)NC[C@H1]3CCOC3)=CO2 O=C(NC[C@@H1]1CCCCN(C(=O)C2=CC3=CC=C(Cl)C=C3OC2)C1)C4=CCCC4 CC[C@@](C)(CO)C(=O)N[C@H1]1CN(C(=O)C(C)(C)OC2=CC=CC(Cl)=C2)C[C@H1]1C CC1(C)C[C@H1](NC(=O)C[C@H1]2CCCCCO2)CCN(C(=O)C=3SC=CC=3F)C1 CN(C)C1=CC=NC(C(=O)N2CC[C@](NC(=O)CCCC(C)(C)C)(C3CC3)C2)=C1 CCN(CC1=CC=C2[NH1]C=CC2=C1)C(=O)N[C@@H1]3CCC[C@H1](C(F)(F)F)C3 C[C@@H1]1CCC=C1C(=O)N(CCC(=O)N[C@H1](CF)C2=CC=CC=C2)CC3CC3 CC(C)C1=C(C(=O)N2C[C@@H1](NC(=O)[C@@]3(C)CCCCO3)C[C@@H1]2C)C=NN1CCO O=C1C[C@@H1](C(=O)N2CC[C@H1](OCCNC(=O)C3=COC(C4CCC4)=N3)C2)CN1 [N-1]=[N+1]=NCCCCCC(=O)NC[C@H1](CC1CC1)C(=O)N[C@@H1]2CC(=O)N(O)C2 C[C@H1](C(=O)NC1=CC=CC(C2=CC(F)=CC=C2OC(F)F)=N1)N3C=CC=C3 CC[C@H1](CNC(=O)[C@H1]1CCC[C@H1]1C(=O)OC)NC(=O)CCOCCOC N#CC1=CC=C(C(=O)N[C@@H1]2CCN(C3=NC=NC=C3Br)C2=O)C(F)=C1 C=CC[C@H1](CC(=O)N1CC[C@@H1](O)C(F)(F)C1)NC(=O)CSC(F)(F)F C[C@@H1](OC1CCCCC1)C(=O)NC[C@H1]2C[C@H1](N=C3[NH1]C=CC(C#N)=C3[N+1](=O)[O-1])C2 C=CCCN1C=C(C(=O)N[C@@H1](CC)CN(C)C(=O)C=2N=CN(C)N=2)N=N1 O=C(NCCC1CN(C(=O)C2=CC=CC=3ON=CC2=3)C1)[C@H1]4CCC5=NN=CN5C4 CCCO[C@@H1]1CCCN(C(=O)C[C@]2(C)CCN2C(=O)C3=CC=CC(C)=C3F)C1 C/C=C/C[C@H1](CC)C(=O)N1CC=C[C@H1]1C(=O)NCC23CC(CN2C)C3 C[C@H1](OC(=O)C1=CC=C2C=C[NH1]C2=C1)C(=O)NCC(F)(F)F CC(C)(CC(=O)N1CC[C@H1]2C[C@]2(NC(=O)C3=CC=CC4=NN=CN34)CC1)C(F)F CC1=CC(C(=O)N[C@H1](C)[C@@H1]2CCCCN2C(=O)C3=CC=C(C(N)=O)O3)=C(O)N=N1 C[C@H1](C(=O)N1C[C@H1](CO)[C@H1](NC(=O)CN2CCCCC2)C1)N3CCCC3 CO[C@@H1](COC(=O)CCC1=CC=C2C(=N1)NCCC2)C3=CC=C(C)C=C3 C#C[C@]1(O)C[C@@H1](C(=O)NC[C@@H1]2CN(C(=O)[C@H1]3C[C@@](F)(CO)C3)CC24CCC4)C1 CC1(C)[C@H1](CNC(=O)CCOC[C@H1]2CCCO2)CCN1C(=O)C3=CC(=O)C=C[NH1]3 C#CC1=CC=CC=C1CC(=O)N[C@@H1]2[C@@H1]3CCCN(C4=NC=C(Br)C=N4)[C@@H1]3C2(C)C CN(C)C(=O)CC(=O)NC[C@H1]1[C@@H1](C(=O)N2CCC(N=[N+1]=[N-1])CC2)C1(C)C CN1CCC2=CC(C(=O)N3CC[C@@H1](NC(=O)C4CCC(F)CC4)C35CC5)=CC=C21 CN1C=C(NC(=O)N2CCN(C3=CC=CC(Br)=C3)CC2)C(C4CCCCC4)=N1 C[C@@H1](C(=O)N(C)CC1CCN(C(=O)C=C(Cl)Cl)CC1)C(F)(F)F CCO[C@H1](C(=O)NCCC[C@@H1](C)NC(=O)CONC(=O)OC(C)(C)C)C1CCC1 CCN(C[C@@H1](C)NC(=O)CC12CC3CC(CC(C3)C1)C2)C(=O)C4C(C)(C)C4(C)C C=CCN(CC=C)C(=O)[C@]1(C(C)C)CCN(C(=O)[C@H1]2C[C@@H1]2C(C)(F)F)C1 O=C(N1CCC1)C2(F)CCN(S(=O)(=O)CC3CCCC3)CC2 CC(C)[C@@H1]1C[C@H1]1C(=O)NCC=2OC=NC=2C(=O)N(C)C3CC(F)(F)C3 COC1=CC(N)=C(C(=O)N2CCSC[C@@H1]2CCNC(=O)[C@H1]3CCC3(C)C)C=C1F C#CC1=CN(C)N=C1C(=O)N2[C@H1]3CC[C@H1]2CN(C(=O)C(=O)NCCC(N)=O)CC3 CCCC[C@H1](O)C(=O)NCCN(CCC)C1=NC2=CC=C(N)C=C2S1 C=CCCCN(CC)[C@H1](CCC1=CC=C(F)C=C1)C(=O)N[C@@H1](C)C2=CC=CC=C2 CCN(CC(F)F)[C@H1](CCC1(C#N)CC1)C(=O)NC2=CC=C(F)C=C2C C[C@@H1](C(=O)N1CC(C=2OC=NC=2CN3C=C(C(C)(C)N(C)C)N=N3)C1)C(F)(F)F CCCC1(C(=O)N(CCO)C2CCN(C(=O)[C@H1](C)[C@@H1](C)O)CC2)CCC1 COCCOCC(=O)N1CCC[C@H1](C)[C@H1]1CN=C2N=C(C(F)(F)F)[NH1]S2 CC(C)(C)[C@H1]1CC(C(=O)NC[C@H1](O)CNC(=O)C=2C=CN3N=NN=C3C=2)=NO1 O=C(C=CC1=CSC=N1)N2CCC(CCCNC(=O)[C@]3(F)CC=CCC3)CC2 C=CCN1C=CN=C1C(=O)NC[C@@H1]2CN(C)CCN2C(=O)CC3=CN=CC(C)=C3 CC1=CSC=C1C(=O)N[C@@H1](C)C(C)(C)NC(=O)C2=CSC3=NC=CN23 O=C(N[C@@H1]1C=CCN(C(=O)C2=CC=C(O)C(F)=C2)C1)C3=C(Cl)CCC3 COCCN1C=C(C(=O)N[C@@H1]2CN(C(=O)[C@]3(C)CCCN3C(C)=O)C[C@H1]2C)N=N1 CC[C@@H1](C(=O)N[C@H1]1C[C@H1](C(=O)N[C@@H1](C)C2=CC=CC(Br)=C2C)C1)C3=CC=CC=C3 CC(C)C1=CON=C1C(=O)NC2CC([C@@H1]3CCN(C(=O)CC4(O)CCCC4)C3)C2 C[C@@H1](CNC(=O)CCOCC(F)(F)F)NC(=O)C1=C[NH1]C2=C(F)C=CC=C12 CN(CC1=CCS(=O)(=O)C1)CC2=CC(=O)NC(=O)[NH1]2 CC1=CC=C(C(=O)N2CCC[C@@H1]2CNS(=O)(=O)CC3CCC3)O1 C#CC1=CC=C(C(=O)N2CC=C[C@H1](NC(=O)[C@H1]3C[C@@](C)(O)C3)C2)C(F)=C1Cl CN(CC(=O)N1CCCC[C@H1](NC(=O)CCCN2C=CN=C2)C1)C3=NC=CC=N3 CC[C@](C)(O)CNC(=O)C[C@]1(C)CCN(C(=O)C2=CC=C(N)C(F)=N2)C1 CC1(C)C[C@@]1(C)C(=O)N2CC[C@H1](C3CC3)[C@H1]2CN4C=C(CCN5CCCC5)N=N4 C=CCCCC(=O)N[C@@H1](C(=O)N(C[C@@H1](O)CO)C(C)C)C1CCC1 C#CC(CO)(CO)NC(=O)C[C@@H1]1CCCN(C(=O)CNC(=O)OCC)C1 CC1=CC(F)=C(Cl)C=C1C(=O)N[C@@H1]2CCC[C@@H1](NC(=O)[C@H1]3C[C@H1](O)C3)C2 C[C@H1](CC1CC1)C(=O)N2CCC[C@@H1]2CN(C)C(=O)C3=CC=C(F)C=C3C#N CC(C)[C@@H1](O)CC(=O)NCCC1(C(=O)N2CCC23CCOCC3)CCCC1 C=C[C@@](O)(C(=O)N1CC=C[C@H1](NC(=O)C(C)(C)OC(C)C)C1)C(F)(F)F C=C1C[C@@H1]1C(=O)NC[C@@]23CC[C@@H1](CN(C(=O)COCC4=NC=NN4C)C2)C3 CCN1CC[C@H1]1C(=O)NC2(C)CCN(C(=O)C3=CC(Cl)=C(Cl)C(Cl)=C3)CC2 CCC[C@@H1](C)C(=O)N[C@H1]1[C@@H1]2C[C@H1]1N(C(=O)CN(C)C3=CC=NC=C3)C2 CC=1N=C(N(C)C)SC=1C(=O)NCC[C@H1](C)NC(=O)C2=CN=CC(F)=C2Cl C=C[C@@](C)(CC)NC(=O)C1(CCNC(=O)[C@@H1]2CCNC2=O)CCC1 COC[C@H1]1C[C@@H1](CNC(=O)CSC(F)(F)F)N(C(=O)[C@@H1]2CCCN(C)C2)C1 CN(C[C@H1]1CCCO1)C2=CC=NC(N3CCN(C4=CC=NN=C4)CC3)=N2 CN1C=C([C@@H1](O)C(=O)N2CC3(CC[C@H1]3NC(=O)C4=CC5=C[NH1]C=NC5=N4)C2)C=N1 C[C@H1](C(=O)N1CCN(C(=O)C2C[C@@H1]3C[C@H1]3C2)CC(C)(C)C1)C4CCC4 C=CC[C@H1](CC)C(=O)NCC(C)(C)CN(C)C(=O)C1CCC(OC)CC1 C[C@@H1]1CC[C@H1]1N(C)C(=O)[C@@H1](C)N(C)C(=O)C2=CN3C=CC=CC3=N2 COC1=CC(C)=CC(C(=O)NC[C@@H1]2C[C@@H1](C)N(C(=O)C(C)(C)S(C)(=O)=O)C2)=C1N CC(C)CC1=CC(C(=O)N[C@H1]2CCCC[C@@H1]2NC(=O)C3=CN=C(S)[NH1]3)=CC(O)=N1 O=C(NC1CC2(CCN(C(=O)CSCC3=CSC=N3)CC2)C1)[C@H1]4C[C@@H1](O)[C@H1](F)C4 CN1C=C(C(=O)N[C@@H1]2C[C@H1](NC(=O)C3=CC=C(F)C(F)=C3N)C[C@H1]2O)C=CC1=O CN1CC[C@H1](C(=O)N2CC(C)(C(=O)NC3=CC=C4C(=C3)COC4=O)C2)C1 CSC1=NC=C(C(=O)NC[C@@H1](O)CN(C)C(=O)[C@](C)(O)C(C)C)N1C CN1N=C(C(N)=O)C=C1NC(=O)[C@@H1]2C[C@@H1](F)CN2C(=O)[C@@H1]3CCC4=CC=CC=C43 C[C@@H1](CNC(=O)[C@@H1](F)OC(F)(F)F)CN(C)C(=O)C=CC1=CC=CC=C1Cl CC1=NO[C@@H1](C(=O)N2CC[C@@H1](CNC(=O)CCC=3C=C(C)[NH1]N=3)C2)C1 C=C[C@H1](CC)CC(=O)N1CC[C@]2(C(=O)O)CCC[C@H1]12 CCS1[C@H1](CNC(=O)CCC[C@H1](CC)NC(=O)[C@H1](C)CCCOC)C1 CC[C@@H1](C(=O)OC)N(C)CC1=CC=C(C(=O)NCCN(C)C)C=C1 CCC(C)(C)OCC(=O)NC[C@H1]1CN(C(=O)[C@@]2(C)CCC(=O)N2)CC1(C)C CC1=CC=CN=C1C=CC(=O)NCCC2(NC(=O)CCCN3C=NC=N3)CCC2 CC(C)C[C@@H1]1C[C@H1]1C(=O)N[C@@](C)(CNC(=O)C2CN(S(C)(=O)=O)C2)C3CC3 COCC1=CC=C(C(=O)N[C@H1]2[C@@H1](C(=O)NC[C@]3(O)C[C@@H1](O)C3)C2(C)C)O1 CC[C@@H1]1CCN1C(=O)[C@@H1]2CN(C(=O)[C@@H1]3CC4=NC=CN4C3)CC25CCC5 C=C1CC(CC(=O)N[C@H1](CCCC)CNC(=O)[C@@H1]2CS(=O)(=O)CC23CC3)C1 CCCCCCC(=O)NC1CCC2(CC1)C[C@H1]2NC(=O)CCS(=O)(=O)C(F)(F)F CC1=NNC(=O)[C@H1]1CC(=O)N2C[C@@H1]3C[C@H1](C2)C3NC(=O)C4=CC=5OC=CC=5S4 CCC1(C(=O)NC[C@@H1]2CN(C(=O)CC3(C(F)(F)F)CCC3)CCN2C)CCC1 CCC=CC(=O)N1CCC(CCOC)(NC(=O)C=2[NH1]N=NC=2C)CC1 O=C(CCOC1CC1)N[C@H1]2COC[C@H1]2C(=O)N3CCO[C@H1]4C[C@@H1]43 O=C(N[C@@H1]1CN(C(=O)C2=CC=C(Cl)N=C2O)C[C@H1]1C3CC3)C4=CC(O)=CC=C4Cl CC[C@H1](C(C)C)[C@@H1](NCCC1=CCCCC1)C2=NN=NN2C3CCC3 CC[C@@H1](CNC(=O)C12CCC1CC2)NC(=O)[C@@H1]3CCO[C@H1]3C4=CC=CC=C4 O=C(CCN(CC1CC1)C(=O)[C@H1](O)C2CC(F)(F)C2)N3CCC4(CCCO4)CC3 CC[C@H1](O)C(=O)N1CCN(CC2=CC=C(F)C=C2[N+1](=O)[O-1])C[C@@H1]1CC#N CCN(C[C@H1](C)NC(=O)C=1C=C(C2CC2)[NH1]N=1)C(=O)[C@H1](C)N3C=C(Cl)C=N3 CN(C)C1=CC=CC=C1C(=O)N2CCOC[C@H1]2CNCC3=CC(Br)=C(O)C(Br)=C3 CC[C@@H1](C(=O)N1CC[C@H1]1CNC(=O)C2(OC)CC2)N3CCCC3=O C=C(C)C[C@H1](NC(C)=O)C(=O)N1CC(O)(CCNC(=O)[C@@H1](F)CC(C)C)C1 CCC1=NC(C(=O)N2CC[C@@H1]2CNC(=O)[C@H1](C)SC3=CC=C(F)C(F)=C3)=C(N)S1 COC(=O)C(C)(C)CC(=O)NC[C@@H1](C)CNC(=O)C=1N=N[NH1]C=1Cl CC1=NON=C1CNC(=O)C23CC(CN(C(=O)[C@@H1]4CNC(=O)C[C@H1]4C)C2)C3 CC(C)=C(C)C(=O)N1C[C@H1]2C[C@@]2(CNC(=O)C[C@@]34CCC[C@H1]3C4)C1 CCCN(C)CC(=O)NC[C@H1](C)NC(=O)C1=CN=C(C2CCOCC2)N=C1C CN1C=NC(NC(=O)C2=CC(NCC3=CC(Cl)=CC=C3OCC4CC4)=CS2)=N1 COC[C@H1](C)C(=O)N1CC[C@H1](O)[C@@H1](NC(=O)C[C@@H1]2CCC(C)(C)O2)C1 CN(CCC[C@H1](O)CO)C(=O)[C@@H1]1CNC2(CC2)CO1 CN1C=CC=C1CN2CC[C@@H1]3[C@H1](CCCN3C(=O)C45CC(CO4)C5)C2 CC[C@@H1]1C[C@H1](C)CN1C(=O)[C@@H1](C2CC2)N(C)C(=O)C[C@]3(O)CCOC3 COCC1(CC=2N=C(C3=CC4=CC=CN=C4C=N3)N([C@@H1](C)C5CCC5)N=2)CC1 CS(=O)(=O)CC(=O)NC[C@@H1]1CC(F)(F)CN1C(=O)[C@@H1]2C[C@H1]2C3=CC=CC(F)=C3F CC1=CC=CC=C1[C@H1]2CN(C(=O)C3=CN=C(C(=O)OC(C)(C)C)C=N3)CCO2 CCN(CCNC(=O)C1=CN=C(Br)S1)C(=O)[C@@H1]2C[C@H1]2C(=O)OC(C)(C)C CC(C)OC1=CC=CC(C(=O)NC[C@H1]2C[C@@H1]2NC(=O)C3=CC(F)=C(F)C(F)=C3)=N1 COC1=CC=C2N=CN=C(N(CC=3C(C)=NN(C)C=3Cl)[C@@H1]4CNC[C@H1]4O)C2=N1 N=C1C=CC(C(=O)N2C[C@@H1]3C[C@]3(NC(=O)C4=CC(O)=NC=C4Br)C2)=C[NH1]1 O=C(CC1CC(F)(F)C1)NC[C@@H1](NC(=O)C=2N=C[NH1]C3=NC=NC=23)C4CC4 CCCNC(=O)[C@@H1](C)NC(=O)CCNC(=O)CC1(C(F)(F)F)CC1 C#CC1=CC=C(C(=O)N2CCO[C@@H1](CC(=O)N(C)[C@@H1]3CCC(C)(C)C3)C2)O1 COC1=CC=C(CC(=O)N2C[C@@H1](C)C[C@H1]2C(=O)NC[C@@H1](C)O)C3=CC=C(C)C=C13 COC1=CC(C(=O)N2CC[C@](O)(C(=O)N3CCO[C@@H1](CO)C3)C2)=CC=C1F CC[C@@H1](C)C(=O)NC1CC(NC(=O)[C@H1]2C3CCC(CC3)[C@@H1]2C(F)(F)F)C1 C=CCCO[C@H1](C)C(=O)N1C[C@H1](C)[C@@H1]1C(=O)NC[C@H1]2CCC(=O)O2 CC(C)[C@@H1](C(=O)N1CCC[C@@H1](NC(=O)[C@@H1]2COCC(C)(C)O2)C1)N3C=NN=C3 CCC[C@@H1](C)NC(=O)C1=CC=C(CNC(=O)C2=CC=NN2C(F)F)N=C1 O=C(NC[C@@H1]1OCC[C@H1]1C(=O)N(CCF)CCOC23)CCC(C2)C3 C#CCN1C=CC=C1C(=O)N(C)[C@@H1]2CC[C@H1]3CN(C(=O)COC4(C)CCC4)C[C@@H1]32 COCC1=CC=NC(C(=O)NC[C@H1](C)C2CCN(C(=O)[C@@H1](C)O)CC2)=C1 C=C(C)C(C)(C)C(=O)N[C@H1](CC(=O)N(C)CCF)C(C)(C)C COC(=O)C1=CC(S(=O)(=O)N(C)CC2=CC(F)=C(F)C(F)=C2F)=CC=C1I C[C@H1](CNC(=O)[C@H1](C)C(C)(C)C)CC(=O)NCC1=CC=CS1 CCOC(=O)N(C)CC(=O)N[C@H1]1CCN(C(=O)C2=CSC(C(F)(F)F)=C2)C[C@@H1]1C O=C(N[C@]12CCCN(C(=O)CC3=CSC=N3)C[C@H1]1C2)C4=NOC5=C4CCCCC5 CC1=CC(Br)=CC(CNC(=NCCF)NC[C@@]2(O)CCCC[C@H1]2C)=N1 CCC1=CC(O)=CC(NC(=O)C=2C=C(CNC(=O)COCC(=O)NC)[NH1]N=2)=C1 CN(C(=O)C1=NC(Cl)=CC=C1Cl)[C@H1]2CCCC[C@@H1]2N(C)C(=O)C=CC=3C=C[NH1]N=3 C[C@@H1](CC(=O)N[C@@H1]1C[C@@H1]1CNC(=O)C=CC2=CC=NC3=CC=CC=C23)C(C)(C)C C[C@@H1]1OCC[C@H1]1C(=O)NCCNC(=O)[C@H1]2CCCN(C(=O)CCC=3C=NOC=3)C2 CC1=CC=CC=C1CNC(=O)CNC(=O)[C@@]23CCC[C@@H1]2C3(F)F C=C[C@@H1]1OCC[C@H1]1C(=O)NC[C@H1]C2N(C(=O)CC3(O)CCC3)CCC24CC4 COC(=O)C1=CC(C)=NC(N2C[C@H1]3CCCN(C(=O)C[C@H1](O)C4CC4)[C@H1]3C2)=N1 O=C(CC12COCC(C1)C2)N[C@@H1]3CC4[C@@H1]CN(C(=O)[C@H1]5C[C@H1](O)C5)C[C@@H1]3C4 COCC1(CNC(=O)C2=CC(C)=NO2)CN(C(=O)CCC(C)(C)OC)C1 C[C@@H1](CC1=CC=CC=C1)C(=O)N2CC3(CC(NC(=O)[C@@H1]4[C@H1]5COC[C@H1]54)C3)C2 CC[C@H1]1CCN(C(=O)C2=CSN=C2C)[C@H1]1CNC(=O)[C@H1](SC)C(C)C C=C1CCC(C(=O)N(C)CCOCCN(C)C2=NC=C(Cl)C(C)=C2C#N)CC1 CC(C)N1C=C(C(=O)N[C@@H1]2COC3=CC(CNC(=O)CC#N)=CC=C32)C=CC1=O CCC[C@H1]1CCCC[C@]1(NC2=CC=C(O)C=C2C)C3=NN=NN3CCCOC CCC1=CC=C(CS(=O)(=O)N2CCCC[C@H1]2[C@@H1]3CCCN(C(=O)C(C)=O)C3)C=C1 CC1=CC(C#N)=NC(N2CC(O)(CCNC(=O)C=3SC(C)=NC=3C)C2)=N1 COC1=CC(C(=O)NC[C@H1](NC(=O)[C@H1](C)CSC)C2CCCC2)=NN=C1C3CC3 COC1=CN=CC(C(=O)N2CCCC[C@H1]2CCNC(=O)C3=CC=C(F)C=C3)=N1 CC1CN(C(=O)C2=CC(C(C)(F)F)=N[NH1]2)CCN1C(=O)C3=CSC=C3 CC1=CC=C(C(C)NC(=O)NCCC2=CC=C(Cl)N=C2C)S1 CC(C)[C@H1](CC1CCCCC1)C(=O)N2CCCO[C@@H1](C3=CC=C(Br)C=C3)C2 C#CC1(C(=O)N(C)[C@@H1](C)C2CCOCC2)CCN(C(=O)[C@@H1](O)C=CC)CC1 CC1=CC(Cl)=C(NC(=O)C2=CC=C(NC(=O)CCCN3C=CN=C3C)C=N2)C=C1 O=C(NS(=O)(=O)CC[C@@H1]1CCOC1)C2=CC=C([N+1](=O)[O-1])C3=CC=CN=C23 CC1(C#CC(=O)N[C@@H1]2CC23CCN(C(=O)CCCC4CCCC4)CC3)COC1 C=C[C@@H1]1CC[C@H1]1C(=O)NC[C@H1]2CCN(C(=O)C=3C=C(C4CC4)N(C)C=3C)C2(C)C CC[C@H1](CNC(=O)C(C)(C)CC(F)F)NC(=O)[C@@H1]1CCCN(C)C1 COC1=CC=C(F)C(C(=O)COC(=O)C2=C(Cl)C=CC=C2OCC3CC3)=C1 CC(C)(F)CNC(=O)[C@@H1]1C[C@@H1]2C[C@@H1]2N1C(=O)C(C)(C)CC#N C[C@H1]1CN(C(=O)C=CC2CCOCC2)CC[C@H1]1C(=O)NC(C)(C)CN3CCCC3 CNC1=CC=CC(C(=O)N[C@H1]2C[C@@H1](NC(=O)[C@H1](C)C=3C=C[NH1]N=3)C2)=N1 C#CCCCCCC(=O)N1C[C@@H1](CN=C2C=C[NH1]C(C(=O)OC)=N2)C[C@H1]1C CC(C)(C(N)=O)C(=O)N[C@@H1]1C[C@H1]1NC(=O)C2=CC=C(N)C=N2 COCCC1=N[NH1]C(=N[C@@H1]2CCCC[C@@H1]2NC(=O)C=3N=COC=3[C@H1]4CCCO4)S1 CC1=N[NH1]C=C1C(=O)N2CC[C@H1](C)[C@H1](NC(=O)/C=C/C=C/C3=CC=CC=C3)C2 COC(=O)CC1=CC=C(C(=O)N2CC([C@H1](C)NC(=O)[C@@H1]3C[C@H1]4CCC[C@H1]43)C2)C=C1 C=CCC[S@@](C)(=O)=NC(=O)C1=C(OC)C=CC(Br)=C1C C[C@H1](CNC(=O)C1=CC=C2C(=C1)OCO2)N(C)C(=O)[C@](C)(F)C3=CC=C(F)C=C3 CSCC=1C=C(C(=O)N2C[C@H1](O)C[C@@H1](NC(=O)C3=NOC=C3Cl)C2)SC=1C CC[C@@](C)(O)C(=O)N(C)CC[C@@H1](NC(=O)C1=COC=N1)C(C)(C)C CC(C)(NC(=O)C1=CC2=C(C=C1N)CCC2)C3=CN(CC(F)(F)F)N=N3 CC1=CC=CC(SCC(=O)NC[C@H1]2[C@@H1]3C[C@H1]2CN3C(=O)[C@@]4(O)CCOC4)=C1 C[C@@H1]1CN(C(=O)C2=CC(S(N)(=O)=O)=CC=N2)CCN1C(=O)[C@H1]3COC(C)(C)C3 COC1=NN(C)C=C1C(=O)NC2CC3(C2)C[C@H1]3C(=O)NC[C@H1](O)C4CC4 C[C@@H1]1CN(C(=O)C(=O)NC[C@H1]2C[C@@H1]2C3CCCC3)CC4(CCC4)O1 CS(=O)(=O)NCCC(=O)N1CCN(C(=O)CCC2=NC=C(F)C=N2)[C@@H1]3COC[C@@H1]31 CCN(CC)C1=CC=C(C(=O)N2CC(C)(NC(=O)COC[C@H1]3CCCO3)C2)C=N1 CCC1=CON=C1C(=O)N2CC[C@@](OC)(C(=O)NCC3=NN(C)C=C3C)C2 COC1=CC(Cl)=CC(C(=O)N[C@H1]2C[C@@H1]2C(=O)N3CCC4(CC3)CC(=O)N(C)C4=O)=C1 CC(C)[C@](C)(CNC(=O)CCNC(=O)CO)NC(=O)[C@H1]1CCC2=C(Cl)C=CC=C21 O=C(CS(=O)(=O)CC(F)(F)F)N[C@H1](CNC(=O)[C@@H1]1C[C@@H1]2CSC[C@@H1](C2)C1)C3CC3 C[C@H1]1C[C@@H1](NC(=O)C(C)(C)C2=CCN(C(=O)C[C@H1]3CCCC34CC4)C2)CCN1C CCCN1C=C(C(=O)N2C[C@H1](CNC(=O)CC3=N[NH1]C=C3Br)C[C@@H1]2C)C=N1 CC[C@@H1]1CCC=2SC(C(=O)N3CC(O)([C@H1](C)NC(=O)CC(F)(F)F)C3)=CC=2C1 CC(C)(NC(=O)[C@@H1](O)CCNC(=O)CC1=CC=C(O)C=N1)C2=CC=CS2 CC1=NC=CC(CCC(=O)N2CCC[C@H1](NC(=O)[C@H1]3CCC(=O)O3)C2)=N1 NC(=O)C1=CC=C(C(=O)N[C@H1]2CCC[C@H1]2NC(=O)C3=CC=C([N+1](=O)[O-1])S3)S1 C[C@H1](C[C@@H1](C)NC(=O)[C@H1]1CCN(C)C1)NC(=O)C2=CC=CC(C#N)=C2Br COC[C@@H1]1N(C(=O)[C@@]2(NC(=O)[C@@H1](OC)C(C)C)CCC(C)(C)C2)CC1(C)C C=CCNC(=O)NC(C)(C)C(=O)N(CCNC(=O)[C@H1](OC)[C@H1](C)CC)C1CC1 CN(C)CCC1=CC=CC(C(=O)N2CC[C@H1](C3CN(C4=NC=NS4)C3)C2)=C1 COC1=CC=C(C(=O)NC[C@H1]2CN(C(=O)[C@H1](CC(C)C)OC)CCN2C)N=C1Cl C[C@H1](NC(=O)[C@@H1](C)N1CCC1)C2CCN(C(=O)C3=NC(O)=NC(O)=C3F)CC2 C=CC[C@H1](C(=O)NCC[C@@H1](C)NC(=O)C1=CC=C2C=C[NH1]C2=C1)C3=CC=CC=C3 CC=1SC=C(C(=O)N2CC(C3CCN(C(=O)C4(C)CC(F)C4)CC3)C2)C=1N C[C@H1]1CC[C@@H1](NC(=O)C2=NN(C)C3=C2CCC3)CN1C(=O)C4=NC=CC(N)=C4Cl CC(C)(C)C[C@@H1]1CN(C(=O)COCC(F)F)CCN1C(=O)CC[C@@H1]2CCC(=O)N2 CC1=NC(=NCC2=CC=C(C3=CC=CO3)C=C2)[NH1]C(NCC4=NC=C(Cl)N4C)=N1 CCCC1=NOC2=NC=C(C(=O)N[C@@]3(C)CCN(C(=O)[C@@H1](C)CF)C3)C=C12 CC[C@H1](C)NS(=O)(=O)C1=CC=C(C(=O)N2C[C@H1](C)CC[C@H1]2C)O1 O=C(CCSC1=CC=C(Br)C=C1)NC2=NC=NC3=CC(Cl)=CC=C23 CCC1=NC=CN=C1C(=O)N2CCC(O)(CCNC(=O)C[C@@H1]3COC(=O)C3)CC2 CN1N=CC(C(=O)N2CCC(CCCNC(=O)/C=C/C=3C=COC=3)CC2)=C1C#N CCCCC[C@H1]1CCCN1C(=O)[C@H1]2[C@H1]3CC[C@H1]4[C@@H1](C3)C[C@H1]42 CC(C)(C)OC(=O)NCCC(=O)NCCCCCNC(=O)CCCCC(N)=O C[C@@H1]1CCC[C@H1](C2=CN(C3CN(C(=O)CC4=CC(Br)=CN=C4F)C3)N=N2)C1 CCCCN(C)C(=O)CCC[C@@H1](C)NC(=O)C1=CC(CO)=CC=N1 CCN1C(=O)CC[C@@H1]1C(=O)N2C[C@H1](C)[C@@H1](NC3=NC4=CC=CC=C4O3)C2 CC=1N=C2C=CC=CN2C=1C(=O)NCCNC(=O)C3CC4(C3)C(F)(F)C45CCC5 CC1=CC=CN=C1CCC(=O)N2C[C@@H1](CNC(=O)C=3N=NN4C=3CCC4)C[C@H1]2C CC1=NN=NN1CC(=O)NC23CC(CNC(=O)C4=CN(C)N=C4C5CC5)(C2)C3 CC[C@@H1](N[C@H1]1CCC2=C1C=C(F)C(F)=C2F)C3=NC(C(F)(F)F)=CS3 O=C(COC1=CC=CC(F)=N1)NC[C@@H1]2CC[C@H1]2NC(=O)C3=CC=NN4C=CN=C34 C[C@@H1](CC1CN(C(=O)C2CC3(C2)CC4(CC4)C3)C1)NC(=O)[C@@H1](C)C=5C=NN(C)C=5 C[C@@H1](C(=O)N(CCO)CCC(=O)N(C)[C@@H1]1CCN(C2CC2)C1)C3=CN=CN=C3 CC1=NOC=C1CC(=O)N[C@@]23CCCN(C4=NC=CC(S(C)(=O)=O)=N4)C[C@@H1]2C3 C=C[C@H1](OC)C(=O)N1C[C@@H1](O)C[C@H1]1C(=O)NC[C@@H1](O)C2=CC=CC=N2 CCC[C@@H1](CC)CCC(=O)N[C@]12CC[C@H1]1CN(C(=O)CC=3C=C(C)ON=3)C2 C=C(C)C[C@H1](NC(C)=O)C(=O)N(CCNC(=O)CC=1C=CSN=1)CCOC CCC[C@H1](C)C(=O)N1CC2(NC(=O)CC=3C(C)=NN(C(C)C)C=3C)CC1C2 CN(C)CC(=O)NCC(=O)N[C@@](C)(CO)CNC(=O)[C@@H1]1CCCC=2N=N[NH1]C=21 C[C@H1](C(=O)NC1([C@H1]2CCN(C(=O)C=3C=C[NH1]C=3)C2)CC1)N4CCOC4=O O=C(C[C@@H1]1CC2=CC=CC=C2N1)N3C[C@H1]4C[C@@H1](N5C[C@H1]6CC[C@H1]5C6)[C@H1]3C4 CC(C)C1=CC=C(C(=O)NC2CC3(CC(NC(=O)[C@@H1]4NC(=O)O[C@H1]4C)C3)C2)C=N1 C[C@@H1](O)CCCNC(=O)[C@H1]1CCCCCN1C(=O)C2=CC(CO)=CC=N2 CCC1(C(=O)NCC[C@@H1](NC(=O)C2=CN=C3[NH1]C=NC3=C2)C(C)C)CCOCC1 CCC[C@@H1]1CN(C(=O)C2=CC(F)=NC=C2OC)CCN1C(=O)[C@H1](SC)C(C)C CC1=CC=CC(C(=O)C(=O)N[C@@H1]2CCCC[C@@H1]2NC(=O)[C@@H1](C)P(C)(C)=O)=C1 CS(=O)(=O)CC(=O)N[C@H1](CC1=CC=CC=C1Br)C(=O)N2CC[C@H1](F)[C@H1](F)C2 O=C(NC1=NC=CC2=CC=NC=C12)N(CCOCCO)C3CCCCC3 CN1C=NC=C1[C@@H1](CO)NC(=O)C2(N(C)C(=O)[C@@H1]3CCC(C)(C)OC3)CC2 CC[C@@H1](C)NC(=O)[C@H1](C)N(C)CCCN(C)C(=O)C1=CC=C(COC)C=C1 C#CC(C)(C)C(=O)N[C@@H1](CCN(C)C(=O)C1=CC=C2C(=C1)NCCS2)C(C)(C)C CC1=C(C(=O)NC[C@H1]2CN(C(=O)[C@H1](NC(N)=O)C(C)(C)C)C[C@H1]2O)CCCO1 CCCCCC(C)(C)CNC(=O)[C@]1(CC)CCCN1C(=O)C2=CC=CC(F)=C2F C[C@@H1](NC(=O)CCCC1=NN=CN1C)C2(O)CN(C(=O)C3(N(C)C)CCC3)C2 CN(CC=1C=NN(C)C=1)C(=O)[C@@]2(C)CCN(C(=O)C3=CN=CC=N3)C2 C=C=C(C)CC(=O)N(CC)C1CCN(C(=O)[C@@H1]2C[C@@H1]2C3CCCCC3)CC1 O=C(CCC=1C=CSC=1)N2C[C@@H1]3[C@@H1](C2)[C@H1]4CC[C@@H1]3N(C(=O)CC5CSC5)C4 CC[C@H1]1CN(C(=O)C2CCN(C)CC2)CC[C@H1]1NC(=O)C3=CC=C(F)S3 C[C@@]1(C(=O)N[C@H1]2C[C@H1](CCNC(=O)CC3(C(F)(F)F)SCCS3)C2)C=CCCC1 C[C@@H1](C(=O)N1CC[C@](O)(CNC(=O)[C@H1]2COCCN2CC(F)F)C1)N(C)C N#C[C@@H1]1C[C@H1](F)CN1C(=O)[C@]2(F)CCN(C(=O)C3=CC=CC(O)=N3)C2 CO[C@]1(COC(=O)[C@H1]2COCCN2CC3CCC3)CCOC1 CCSC1=CC=C(C(=O)N2CC(NC(=O)C3=CC(Br)=C(C)C=N3)C2)C=N1 O=C(N[C@@H1]1C=C[C@H1](CNC(=O)[C@H1]2CCCC=3N=N[NH1]C=32)C1)C=4SC=NC=4Cl CCCCO[C@H1](C)C(=O)N[C@@H1](C(=O)NC1(COC)CCC1)C2=CC=CO2 COC[C@]1(NC(=O)C#CC2CCCC2)CCN(C(=O)C3(F)CCOCC3)C1 CCOC=CC(=O)N[C@H1](CNC(=O)C1=CC=C(C)N=C1O)[C@H1](C)C(C)C CC1(C)CCC[C@@H1]1C(=O)N2CC(OC3CCN(C(=O)C4=CN=N[NH1]4)CC3)C2 C[C@H1]1CN(C(=O)C2=CC=C(Br)C=N2)C[C@H1]1NC(=O)C3=CN4C=CC=C(F)C4=N3 CC(C)CC1=CC=C(C(=O)N2CCC(O)(CNC(=O)[C@H1]3C[C@H1]3C)CC2)S1 CC1=CN=C(C(=O)N[C@@](C)(CNC(=O)C(C)(C)C2CCOCC2)CC(C)C)C=N1 COC1(OC)C[C@H1](COC(=O)[C@@H1]2CC[C@H1](CCC(=O)O)C2)C1(C)C C#C[C@H1](NC(=O)[C@]1(F)CCCN(C(=O)CCN(C)CCO)C1)C2CCCCC2 C[C@@H1](O)CC(=O)N1CCSC[C@H1]1C(=O)NCC2=CC=CC(OC3CC3)=C2 CN1N=CC2=NC(O)=C(C(=O)N[C@H1]3C[C@@H1](CCNC(=O)C4=CSC(Cl)=N4)C3)C=C21 O=C([C@@H1]1C[C@H1]2C[C@H1]1[C@H1]3C[C@@H1]32)N4CC[C@H1]5OCCN(C(=O)CCOC6CC6)[C@H1]5C4 CCN(C(=O)C=1C=CN(C)N=1)[C@@H1]2CCCN(C(=O)[C@@H1]3CC4(CCC4)CO3)C2 CC1=NC=NC(C)=C1C(=O)N(C)C[C@H1](C)NC(=O)C2=CC=CN=C2C3CC3 C=CCO[C@H1](C)C(=O)N1CCC[C@@]1(CC)C(=O)N2CC3=CC=NC=C3C2 CC1=NC(O)=CC(C(=O)NC[C@H1]2C[C@H1]2NC(=O)C3=CC(Br)=CN4C=CN=C34)=N1 CC1=CN=CC(C(=O)N2CC[C@@H1](C)[C@H1](CC(=O)NC=3C=CC(=O)N(C)C=3C)C2)=C1 C[C@@H1](C(=O)NCCCNC(=O)C1=CC=C(CCNS(C)(=O)=O)S1)C2CCOCC2 C=CC1(NC(=O)C[C@@H1]2CCN(C(=O)[C@@H1](C)CCCCCC)C2(C)C)CCC1 CN(CC1=CC=CC=C1CNC(=O)C2=C[NH1]C3=CC=CC=C23)C(=O)C(C)(F)F CO[C@H1](CC(C)C)C(=O)N[C@@H1]1C[C@@H1]2CC[C@@]1(NC(=O)C(SC)SC)C2 CC1(C)CCCN(C(=O)C=2C=C(C3CC3)ON=2)[C@@H1]1C(=O)N4CCO[C@@H1](C(N)=O)C4 C=CC[C@H1](CNC(=O)C=1C=NN([C@@H1]2CC2(F)F)C=1)NC(=O)C3=NC(O)=C(C)S3 COC(=O)C1(CCF)CCN(N2CCC[C@@H1](N3C=CN=C3)C2)CC1 CN1N=NN=C1SCC(=O)N[C@@H1]2C[C@H1]2C3CCN(C(=O)C=C4CC4)CC3 CC(C)N(C)CCCCC(=O)N[C@@H1]1CN(C(=O)C=C(Cl)Cl)[C@@]2(CCOC2)C1 CC(C)(C)OC(=O)N1CCO[C@@]2(COCCN(S(=O)(=O)C3=CC(Br)=C(Cl)S3)C2)C1 C=CCO[C@@H1](C)C(=O)N1CC[C@@](C)(CCNC(=O)CC=2C=C(C3CC3)ON=2)C1 CCC(C)=C(C)C(=O)N1CCCC[C@H1](NC(=O)C2=N[NH1]C=C2Cl)CC1 CN1CCN(C(=O)C2=CC(N)=CC=C2Cl)C[C@@H1]1CNC(=O)C3=CC4=C(S3)CCC4 CC(C)CC[C@H1](NC(=O)[C@@H1](C)C1CCC1)C(=O)NC2([C@H1](O)CO)CC2 CN(C[C@@H1](O)CN(C)C(=O)C(C)(C)C1=CC=C([N+1](=O)[O-1])C=C1F)C(=O)C(C)(F)F CC1=NC=NC(O)=C1CCC(=O)N[C@H1]2CCN(C(=O)CN(C)C)[C@H1]2C CO[C@@]1(C(=O)N2CCC3(CCN(C(=O)[C@H1]4C[C@@H1](O)C4)CC3)CC2)CCOC1 C[C@@H1](CNC(=O)[C@H1](F)C1(O)CCCC1)N(C)C(=O)C(=O)N=S(C)(C)=O O=C(COCC=1N=C[NH1]N=1)NCCCOCCNC(=O)[C@@H1]2C[C@H1]2C=3C=COC=3 CC[C@@H1](C)CCC(=O)N1C[C@@H1]2CC[C@H1](C1)N2C(=O)C3=CC=C4C(=C3)NC(=O)NC4 CCCC[C@@H1](C)C(=O)N1CC[C@@H1](NC(=O)C2=CSC(C3=CC=CS3)=N2)C[C@@H1](O)C1 C[C@@H1]1CC[C@@H1]1C(=O)N[C@@H1](CC(N)=O)C(=O)N(C)CCCC(F)(F)F N#CC1=CC=C2C(=C1)CCC[C@@H1]2C(=O)N3CC[C@](CF)(NC(=O)C=4C=CON=4)C3 CC[C@@H1](CC(=O)N1C[C@H1](CNC(=O)[C@H1]2CCCCN2C)[C@@H1](C3CCC3)C1)C(C)C CC(=O)C1=CN(CC(=O)NC[C@@H1](O)CNC(=O)[C@@H1]2CCN3C(C)=NN=C3C2)N=N1 CCC1(CC)CC(NC(=O)C2(NC(=O)[C@@H1]3CCCN3C4CC4)CCCC2)C1 COCCCC(=O)N(C)C1CCC(NC(=O)C=2N=C(Br)SC=2C)CC1 CCN(CCNC(=O)C1(O)CC2(CCOCC2)C1)C(=O)C3=CC(C)=CC(C)=C3O CN1C(=O)CC[C@@H1]1CC(=O)NC/C=C/C(=O)NCC(F)(F)CO CC=1C=NOC=1C(=O)N2[C@H1]3CC[C@H1]2[C@H1](C)[C@@H1](NC(=O)[C@H1](C)C4CC4)C3 CN(C[C@H1](O)CNC(=O)C1=CC2=C(O1)CCCC2)C(=O)CN3C=NC=N3 CC1=NC=C(C(=O)N2CC=C[C@H1]2CNC(=O)[C@H1]3O[C@H1]4CC[C@H1]3C4)N1C(F)F COC(=O)CCS(=O)(=O)N1CCC[C@]12CCCN(C(=O)NCCCl)C2 CC(C)C(=O)NCCN1C=C([C@@]2(C)COCCN2C(=O)[C@H1](C)CC(C)(C)C)N=N1 C=CCOCCCC(=O)N[C@@H1]1C[C@@H1]2CN(C(=O)CC3=CC(F)=C(C)C=C3F)C[C@H1]21 CN(C[C@@H1](O)CNC(=O)C(C)(C)C1CCC1)C(=O)CS(=O)(=O)CCO COC(=O)CCCCC(=O)N1CCC[C@@H1](CNC(=O)CC=2C=NOC=2)C1 CCCN1C=CC(C(=O)NC[C@H1](O)C2CCN(C(=O)C3=C(C)OCCS3)CC2)=N1 CCO[C@H1](CC)C(=O)NC[C@@H1](NC(=O)C1=CC=C(C(C)(C)C)S1)C2CCCC2 CC(C)OCC(C)(C)C(=O)NC[C@]1(F)CCN(C(=O)[C@H1](C)OC2=CC=CC=C2)C1 CN1C=CN=C1SCC(=O)NC[C@@H1]2CCN2C(=O)[C@@H1]3CCS3(=O)=O CCC[C@](C)(O)CC(=O)NCC(F)=C1CN(C(=O)[C@]2(C)CCCO2)C1 CC(C)N1C(=O)CC[C@H1]1C(=O)N2[C@H1]3CCC[C@H1]2CN(C(=O)C4(C5CCC5)CC4)C3 CN(CCCC(=O)NOCCOCCF)S(=O)(=O)C1=CC=CN=C1 CCC1CC(CNC(=O)[C@H1]2COC[C@H1]2NC(=O)CCC3OCCO3)C1 O=C(NC[C@@H1](O)CNC(=O)C1CC(F)(F)C1)C2=NC=NC3=C2C=CN3C4CC4 C12C=NC(C(=O)NCC[C@]1(CF)C(=O)NC[C@H1](C)CC=3C=N[NH1]C=3)=CS2 CCN=C1[NH1]C(C(=O)NC2CC3(C2)CN(C(=O)[C@H1]4CC45CCCC5)C3)=CS1 CCC[C@H1](CNC(=O)C1=CC=C2C(=C1)COC2)C(=O)N3C[C@@H1]4C[C@H1]5C[C@H1]4[C@@H1]3[C@H1]5O C#CCC1(C(=O)N2CC[C@@H1](C)[C@H1](NC(=O)C3=CC=C4C(=N3)CCCC4)C2)CC1 C#CCCC(=O)N1CC[C@@](CNC(=O)CC2=CC=C(O)C(F)=C2)(C(C)(C)C)C1 FC1=CC=C(C2=CC=CC(CN3CCCC=4OC=CC=4C3)=N2)C=C1 CC1=CC(CC(=O)N2C[C@@]3(CNC(=O)[C@@H1](CO)N(C)C)C[C@H1]2CO3)=CC=C1CO CCC[C@H1](C(=O)NC[C@H1]1C[C@H1](C)N(C(=O)C2=CC=CC(F)=C2C)C1)S(N)(=O)=O C#C[C@@H1]1CN(C(=O)CC[C@@H1]2CCCN(C)C2)CCN1C(=O)CCCCC(=O)OC CC1=NC2=CC(F)=CC=C2C=C1C(=O)N[C@H1]3CC(=O)N(C(C)C)C3=O CCC[C@@H1](CNC(=O)[C@@H1](C)COC(C)=O)C(=O)NCC(C)(C)CCO CC[C@H1](CC(=O)N[C@H1]CC[C@@](CCN(C(=O)C1=CC=CN=C1)C)(O)O)SC CC1=C(C(=O)NC[C@H1]2CC[C@@](F)(CNC(=O)[C@H1]3C[C@@H1]3F)CC2)SC4=CC=CC=C14 O=C(N[C@@H1]1C[C@H1]2C[C@@H1](C1)N(C(=O)C3=C(F)C=CC=C3Cl)C2)[C@H1]4CC[C@H1]5C[C@H1]54 CCCOC1=CC=C(C(=O)N[C@H1](CC)CNC(=O)C[C@@H1]2CN3CCC2CC3)C=C1 CCOCC(=O)N1CCC[C@@H1]([C@@H1]2CCN(CC=3C=CN(C(C)C)N=3)C2)C1 CCC=1N=N[NH1]C=1C(=O)N2[C@H1]3CC[C@@H1]2C[C@@H1](NC(=O)[C@H1](F)C(F)(F)F)C3 C#CCC1(C(=O)N2CC[C@@H1]([C@H1](C)NC(=O)C3=CN=CC(N(C)C)=N3)C2)CCCC1 CC(C)(C)[C@H1]1CC(C(=O)NC[C@]2(C)CCN(C(=O)C3=CSC(Cl)=C3)C2)=NO1 CN1CC(N(C)C(=O)[C@H1]2CCC3(CC3)N2C(=O)[C@H1]4COCCO4)C1 CC1=NO[C@](C)(C(=O)NC[C@H1]2CN(C(=O)C3=NC(O)=NC(O)=C3F)CCCO2)C1 COC[C@@](C)(O)C1=NN=C(NCC(C2N(C)C[C@@H1]2CN3CCC=4SC=CC=4C3)=C)S1 CCC=1[NH1]C(=N)SC=1C(=O)N[C@H1]2C[C@H1](C)CN(C(=O)COC3CCC3)C2 CC(C)CC(F)(F)C(=O)N1C[C@H1](O)C[C@@H1](NC(=O)C2CN(S(=O)(=O)N(C)C)C2)C1 CN1CCC(=CC(=O)NC[C@@]2(NC(=O)CCN3C=CN=N3)CCCC[C@@H1]2C)CC1 COC1=CC=C(F)C=C1C2=NOC(C)=N2 CN(C)C1=NOC(CNC(=O)[C@H1](NC(=O)CC2CC(F)C2)C3=CC=CO3)=N1 C[C@@]1(C(=O)N2CC(OCCNC(=O)CCCC3=CC=CN=C3)C2)C[C@@H1]1Br CCCC(C)(C)CC(=O)N[C@H1]1C[C@@H1](CNC(=O)C=2C=CN(C(C)(C)C)N=2)C1(C)C CO[C@H1]1C[C@@H1](CC(=O)N2C[C@@H1]3CN(C(=O)C4=CC=C5C(=C4)N=CN5C)C[C@@H1]3C2)C1 CN1CCN(CC(=O)NC[C@H1](NC(=O)[C@H1]2CCC(=O)N2)C3CCCC3)CC1 C=CCN1N=NN=C1[C@H1](NC2(CC)CCCCCC2)C3=CC(C)=C(C(=O)OC)S3 COCC1=NOC=C1C(=O)N(C)C2CCC(NC(=O)[C@]3(C)C[C@H1](O)CN3C)CC2 N#CC1=CC=C(C(=O)N2CCOC[C@@H1]2CNC(=O)[C@H1]3COC4=CC=CC=C43)O1 CN=C1[NH1]N=C(CC(=O)NC2(C)CN(C(=O)C3=CN=C([C@H1](C)O)S3)C2)S1 COC1=CC=CC=C1[C@@H1](N[C@H1](C)[C@@H1]2CCCOC2)C3=CC=CC=C3 CSC[C@@H1](O)C(=O)N[C@@]1(C(=O)NCCC2=CC=CO2)CCC3=CC(Br)=CC=C3C1 CCC1=CC(C(=O)N[C@H1](C)CCCCNC(=O)C2=C[C@@](C)(CC)C2)=NN1C CC1=NC=CC(C(=O)N2CCC[C@H1]2[C@@H1]3CCN(C(=O)CCCCC(C)(C)C)C3)=N1 CCCN1C=C(C(=O)NC[C@]2(O)CCCN(C(=O)[C@@H1](C)SC(F)(F)F)CC2)C=N1 CCC1(C(=O)N[C@@H1]2CN(C(=O)[C@@H1]3CCC4=NN=C(O)N4C3)C[C@H1]2CC5CC5)CC1 CCC[C@](C)(O)CC(=O)NCC(C)(C)C(=O)N1CCC[C@@H1](CC)CC1 CCO[C@H1](C(=O)N1CC[C@@](C)(NC(=O)C[C@H1]2CCC(=O)N2C)C1)C3CCOCC3 C[C@H1]1CCCC[C@@]1(CNC(=O)COC2=CC(Cl)=CC=C2Cl)NC(=O)CCCF O=C(OCCC=1C=CC2=N[NH1]C=C2C=1)C3=CC(N4CCCC4)=CC=N3 CCSC1=NC(C)=C(CC(=O)N[C@H1]2CC[C@@H1](NC(=O)COCC)C2)S1 CCCCC=1OC=NC=1C(=O)N2CCOC[C@H1](CNC(=O)[C@@H1]3CCC(=O)N3)C2 CCCCC[C@@H1](O)CC(=O)N[C@H1]1CCN(C(=O)C=2C=C(C)[NH1]C(=NC)N=2)C1(C)C C[C@H1](O)C(F)(F)C(=O)NCC1(C(N)=O)CN(C(=O)[C@@H1](O)C2=CC=CC=N2)C1 COC(=O)[C@@H1](CC1=CN([C@@H1]2CCCC[C@H1]2O)N=N1)NC(=O)C3=NC=NC(C)=C3C CC1=N[NH1]C=C1C(=O)NC[C@@H1]2CCN(C(=O)CCN3CCN(C)CC3)C2(C)C CC1(C)C[C@]1(C#N)C(=O)N2CC3=CC=CC=C3C[C@H1]2C(=O)NCC4=CC=NC=C4 CCCCC[C@H1](C)CC(=O)N[C@@H1]1C[C@H1](CNC(=O)C2=CN=CC(F)=C2)C[C@H1]1O CC(C)(CCNC(=O)CC[C@H1]1NC(=O)NC1=O)NC(=O)C2=CC(Br)=N[NH1]2 CCO[C@H1](CC)C(=O)N1CC([C@@H1](O)C(=O)N2CC(C)(C)[C@@H1]2COC)C1 CC[C@H1](C)C(=O)NC[C@H1]1CCC[C@H1]1NC(=O)C2=CC=C(C3CC3)N=C2 O=C([C@@H1]1C[C@H1](O)CN1)N2[C@H1]3C[C@@H1](C[C@@H1]3F)[C@H1]2C(=O)NCCC4(O)CCCCC4 COCN1N=CC=C1C(=O)NCC(C)(C)CNC(=O)C2=CC=C(C(N)=O)C(Cl)=C2 C[C@H1](NC(=O)CSCCC#N)[C@@H1]1CN(C(=O)C2(S(C)(=O)=O)CCC2)CCO1 CCC1=C(C(=O)N[C@@H1]2COCCN(C(=O)CC3=CSN=C3C)C2)CCCO1 NC(=O)NCC(=O)N1C[C@@H1]2C[C@H1](NC(=O)C=3OC=C4C=3CCC4)[C@H1]1C2 CCC[C@H1](CC)C(=O)N1CCN(C(=O)CCC2=CC=C(Cl)C(C)=C2)[C@H1](COC)C1 C=CCN1C=C(C2=NC(CCCO)=NN2C3=CC=NC(F)=C3)N=N1 CCC(CC)[C@@H1](C)C(=O)N1CC[C@H1](C(=O)NC[C@@]2(CO)CC2(C)C)CC1(C)C CN(CCNC(=O)C1=CN2C=C[NH1]C(=O)C2=N1)C(=O)CSC3=NN=CN3C4CC4 C[C@H1](CC(F)F)C(=O)N(C)[C@H1]1CN(C(=O)C=2C=CN(C)N=2)CC[C@@H1]1O C[C@@H1](O)C[C@@H1](C)CN1CC(=O)N(CCC(=O)NC2CC2)C1=O CS(=O)(=O)CCC(=O)N1CCC[C@H1](NC(=O)C2=CC3=C(S2)CCCC3)[C@@H1](F)C1 C=CCCO[C@@H1](C)C(=O)NC1CN(C(=O)[C@@H1]2COC3=CC(O)=CC=C3C2)C1 CCSCCC(=O)N[C@@H1]1CN(C(=O)C2=CN=C(C3CC3)O2)CC[C@H1]1C C=CCC[C@H1](NC(=O)CC1=CSC(C)=C1)C(=O)N2CCC(F)(CF)CC2 CCN(C(=O)C1=CC(C)=CS1)[C@H1]2CCN(CC=3C=CN(C4CCCC4)N=3)C2 CN(C)S(=O)(=O)N1CCC[C@H1](NC(=O)N2CC=C(C(C)(C)C)CC2)C1 CNS(=O)(=O)CC(=O)N[C@H1]1C[C@@H1](CNC(=O)[C@H1](C)N2C(=O)OC3=CC=CC=C32)C1 CC1=CC(C(=O)N(CCNC(=O)CC[C@H1]2CCOC2)C3CC3)=CC(Br)=C1C C[C@H1]1CC=CC[C@@H1]1C(=O)N(C2CC2)C3(C(=O)N(C)CC=4N=C[NH1]N=4)CCC3 CC[C@H1](O)C(C)(C)C(=O)N1CCN(C(=O)C=CC2=CC=CC=C2C)C[C@@H1](C)C1 CCN(C(=O)C1=CC2=CC(Cl)=CC=C2[NH1]1)[C@@H1](C)CNC(=O)[C@H1]3CC[C@H1](C)CC3 C#CCNC(=O)CC(=O)N(C)C1(C(=O)N(C)C[C@H1](O)C2CCC2)CC1 CC=1N=C(C(C)C)OC=1C(=O)N[C@@H1]2CC[C@H1]3CN(C(=O)C4=CC(=O)N(C)O4)C[C@H1]32 CCC(CC)[C@H1](F)C(=O)N1C[C@H1](C)CC[C@H1]1CNC(=O)CN(C)S(N)(=O)=O CC(=O)C1=NC=C(C(=O)N2CC[C@H1]2CNC(=O)[C@H1](N(C)C)C(C)(C)C)S1 C[C@@H1]C1[C@](C(=O)N[C@H1]2CC[C@H1](CNC(=O)C(F)(F)[C@H1](O)C3=CC=CC=C3)CC2)C[C@H1]1 CN(CC1CC1)C[C@H1]2CN(C(=O)CC3=NC=C4C=CC(Br)=CN34)CCO2 CCN(CCOC)C(=O)[C@H1](NC(=O)C=1C=C(CO)N(C)N=1)C2=C(C)C=CC=C2Br O=C(NC[C@@H1]1CN(C(=O)COCC2CC2)CCC1(F)F)[C@@H1]3CCCC4=NN=CN43 CN([C@H1]1CS(=O)(=O)C[C@H1]1O)S(=O)(=O)C2=CC=C(NCCCC(C)(C)CO)C=C2Br COC1=CC=C2C(=C1)OC[C@H1]2CC(=O)NC[C@@H1](C)CNC(=O)C3(O)CC(C)(C)C3 C#CC[C@H1](O)C(=O)NC[C@H1](CC=C)C(=O)N(C)[C@@H1](C)C1=CC=CO1 O=C(NC1CCN(C2=CN=CC=N2)CC1)COC3=CC=CC=C3 CC[C@@H1]1C[C@H1]1NC(=NC[C@@H1](C2=CC=C(C)C=C2)N(C)C)NC3CCC3 C#CCC1(C(=O)N2CCC[C@H1]2CN(C)C(=O)C3=CC=C(F)C=C3O)CCCC1 CC1=N[NH1]C=C1CCN=C(NCC=2C=NN(C)C=2)NCC3CC3 CC(C)(C)CC[C@]1(O)C[C@@H1](C(=O)N2CC[C@@H1](CCNC(=O)C3CCCC3)C2)C1 C=C[C@@H1](C)CC(=O)N[C@@H1](CNC(=O)CN1N=CC=C1C)C2CCC2 CC1=CC(C(=O)NC[C@](C)(O)[C@@H1]2CCCN(C(=O)C3=CN(C)C=C3C)C2)=CS1 CCCN1N=C(CCOC)N=C1C=2SC(C3=CC=CC=C3)=NC=2C(F)F COC(=O)C[C@@H1](CNC(=O)NC1(CO)CCOCC1)C2=CC=C(F)C=C2 CC#CCCCC(=O)N1CC([C@@H1]2CCCCN(C(=O)C3=CC(CC)=CC=N3)C2)C1 CCC[C@@H1](O)CC(=O)N1C[C@@H1]2C[C@H1](C1)[C@@H1](CO)[C@H1]2NC(=O)CC(C)(C)CC(F)F COCC=CC(=O)NCCOCC(=O)N1CCCO[C@@H1](C(C)C)C1 CCCC[C@@H1](CC)CC(=O)NCC=1C=NN2C=1CN(C(=O)C3=CC=C(F)O3)CC2 CCN1N=NC(C)=C1C(=O)NC[C@H1](C)NC(=O)CCC(=O)C2=CC=C(OC)C=C2 CC1=CC(C(=O)N[C@@H1]2CCC23CN(C(=O)C4=CC=CC=C4O)C3)=NC=C1C(F)F CC[C@]1(C(=O)N2CC3=C[NH1]N=C3[C@@H1](C)C2)CCN(C(=O)C=C(C)C)C1 CO[C@H1](C(=O)N[C@H1]1C2CCC(CC2)[C@@H1]1C(F)(F)F)[C@@H1]3CCC(F)(F)C3 CC(C)OC1=CC=CN=C1C(=O)NCC[C@@H1](C)CCNC(=O)[C@H1](O)C2CCCC2 CN1CCO[C@@H1](C(=O)N[C@@H1]2CN(C(=O)C3(C4=CC=C(Br)C=N4)CCC3)C[C@@H1]2F)C1 CC[C@H1](C)C[C@@H1](NC(=O)C1CN(C(C)=O)C1)C(=O)N[C@@]2(C)CN3CCC2CC3 CC[C@@H1](CCOC)C(=O)N[C@](C)(CNC(=O)C1=CC(OC)=NC=C1Cl)C2CCC2 CCN1CC[C@@H1]1C(=O)NCC[C@H1]2CC(F)(F)CN2C(=O)C3=N[NH1]C(C)=C3C CC[C@@H1](CNC(=O)C1CC(N(C)C(=O)C=2C=CN3C=NC=C3C=2)C1)OC CC1=CC=CC(C(=O)N2CCN(C(=O)[C@H1]3CC(=O)N(O)C3)C[C@H1]2CCO)=C1C#N C[C@@H1](O)[C@H1](C(=O)NC[C@@]1(C)CCN(C(=O)C2=CC(O)=NC(C3CC3)=N2)C1)N(C)C CCC1=NN(C)C(C(=O)N2CCC3(CC2)C[C@]3(C)C(=O)N[C@H1]4C[C@H1](N)C4)=C1Cl C[C@H1](C(=O)N[C@@H1](CC=1C=N[NH1]C=1)C(=O)N[C@@H1]2CCC[C@H1]2CF)N3CCOCC3 O=C(CCC1=CC=C(Cl)S1)N[C@H1]2C[C@H1](NC(=O)C3=CN=CC=C3Br)C2 CC1=CC=CC=C1C(=O)N2CCC[C@@H1](C)[C@@H1]2CNC(=O)C3=CC=C(CO)C(Cl)=C3 C[C@H1](C(=O)N1CC2(CC2)C[C@H1]1CNC(=O)C3=CC=C(F)C=N3)C4=CC=CO4 C/C=C/[C@H1]1CN(C(=O)CCCNC(N)=O)C[C@@H1]1C(=O)N[C@@H1]2CC[C@@](C)(CN)C2 CC1=CC=C(C=CC(=O)N2C[C@@H1](C)[C@](C)(CNC(=O)CC3=CC=NO3)C2)N=C1 CC=1C=C(CCC(=O)N(C)[C@@H1]2CCCN(C(=O)[C@@H1]3CC4=CC=CC=C4N3)C2)ON=1 CC(C)(C(=O)NCCCCCNC(=O)C1=CSC(CC(F)F)=N1)C2=CC=CC=N2 CC1(C)CN(CC(=O)N2C[C@H1]3C[C@H1](NC(=O)C(F)=C4CCC4)C[C@H1]3C2)C1 C[C@H1]1CCC=C1C(=O)N2CC[C@H1]3[C@@H1](C2)[C@@H1]3C(=O)NCC4(C)C[C@H1]5C[C@@H1]5C4 CC[C@@H1](CC(=O)N1CCC(O)(CN(C)C(=O)[C@@H1]2CC23CCOCC3)CC1)OC O=C(N[C@@H1]1C[C@@H1]2CC[C@H1](C1)N2C(=O)C3=COCCO3)C4=CN=CC=C4Br CC[C@@]1(C(=O)NCC2(C)CCOCC2)CCCN(C(=O)C=CC=3C=CSC=3)C1 COC1(C(=O)N2CC3(CC(CC(=O)N4C[C@H1]5CCN(C)[C@H1]5C4)C3)C2)CC(C)C1 CCN1C=CC(C(=O)NCCCNC(=O)C=2C=CC(=O)N(C)C=2)=N1 CC[C@@H1](C(=O)N1C[C@@H1]2C[C@]2(NC(=O)C3=CC(=O)C=C[NH1]3)C1)N4C=CN=C4 C[C@H1]1CC[C@H1](CNC(=O)C2=NC(C3CC3)=CS2)CN1C(=O)C4=CC=CC(F)=C4F COC(=O)C1CC(NC(=O)[C@H1](C=2C=CN(C)C=2)N3C[C@H1]4[C@H1](C)[C@H1]4C35CCOCC5)C1 C[C@H1]1C(C(=O)NCC2=CC=CC(N3C=C(C[C@@H1](O)C4=CC=CC=N4)N=N3)=C2)[C@@H1]1C CCC1=NC(C(=O)NCC2(CNC(=O)C=CC3=CN=CC(F)=C3)CCC2)=CS1 C[C@@H1]1CN(C(=O)C2=CC3=CC=C(O)C=C3N2C)CCN1C(=O)C[C@@H1]4CCNC4=O CN(CCO)CC1=CN(C[C@H1]2CN(C(=O)C(F)(F)C3=CSC(Cl)=C3)CCO2)N=N1 CCCCC[C@@H1](F)C(=O)N1CC(F)(CNC(=O)[C@H1](F)CC(C)(C)C)C1 C[C@@]1(CNC(=O)C2=CN=NS2)CC(F)(F)CN1C(=O)[C@@H1]3CCC(=O)C4=CC=CN43 CC[C@H1](O)[C@@H1](C)C(=O)N1CC(=C(F)CNC(=O)[C@H1](C)OCC(C)C)C1 COCCCC(=O)N1CC[C@](O)(C2CCN(C(=O)C=3C=NN4C=3OCC4)CC2)C1 CCC1CC(CC(=O)N[C@H1](C)C(=O)NCC2=CC=NN2C)C1 CN1CCCC[C@@H1]1CC(=O)NC[C@H1](O)CCNC(=O)C2=CN=C(C3CC3)[NH1]C2=N C/C=C/C[C@H1](C)C(=O)NC[C@H1]1CCCN(C(=O)CC=2N=C[NH1]N=2)CC1 C[C@H1](C(=O)NC1CCOCC1)N2CCN(C3=CC=C(F)C=N3)CC2 C=CC[C@@H1](CNC(=O)C1=CC=C2C(=C1)SCCN2)NC(=O)COCCCOC COC1=CC(C(=O)N2C[C@@H1](C)C3=CC=CC=C32)=C(C=4C=NN(CC(C)C)C=4)C=N1 C[C@H1](OCC1CC1)C(=O)NC[C@H1](C)NC(=O)C[C@H1]2CCCCO2 C#CC1=CN(C)N=C1C(=O)NCC2(O)CN(C(=O)[C@H1]3CCC[C@H1]3C(=O)OC)C2 CC(=O)OCCC(=O)N[C@@H1](CNC(=O)C1=CC=C2N=C(O)[NH1]C2=N1)[C@H1](C)C(C)C CCC[C@@H1](C)C(=O)N[C@@H1](CO)CNC(=O)C1=CC=C2N=NN(C)C2=N1 COC1=CC(C(=O)NC[C@@H1]2CCC[C@@H1]2NC(=O)[C@@]3(C#N)CC34CCCC4)=NN1C C#CCN1C=CC=C1C(=O)N(C)[C@H1](C)CNC(=O)[C@@H1](OC)C2=CC=CC=C2 CO[C@@H1](C(=O)NCCN(C(=O)C=1N=NSC=1C)C2CCCC2)C3=CC=CC(Cl)=C3 CC1=C(C(=O)N2CCCC=3OC=CC=3C2)N=NN1CC4=CC=C(F)C=C4 CO[C@@H1]1C[C@H1]2CC[C@H1]1C[C@@H1]2C(=O)NCC3(NC(=O)[C@H1]4CN5CC[C@H1]4C5)CCC3 C[C@@H1]1OCCO[C@@H1]1C(=O)NC2(CNC(=O)[C@H1]3C[C@H1]4O[C@@H1]3[C@@H1]5C[C@H1]45)CCC2 C[C@@H1](OC1=CC=C(Cl)C=C1)C(=O)NC[C@H1]2[C@@H1]3C[C@H1]2CN3C(=O)C=C[S@@](C)=O CN1C(O)=NN=C1CCN=C2C=CC(C3CCC3)=N[NH1]2 CCS[C@H1](C)C(=O)N[C@H1]1C[C@H1]2CC[C@@H1]1N2C(=O)C=3C(C4=CC=CC=C4)=COC=3C COCC=1C=CSC=1C(=O)N[C@@]23C[C@@H1]2CN(C(=O)[C@H1](OC)C4CC4)C3 C=C=C[C@H1](C)C(=O)N(C)C1CC(C(=O)NC2=CC(O)=CC(OC)=C2)C1 COC[C@H1](C)CC(=O)N1CC(O)(C2(CNC(=O)CCCCCSC)CC2)C1 CCCCNC(=O)[C@@H1](COC(=O)C1CCC(C(C)(C)CC)CC1)N(C)C CC[C@@]1(C)CC[C@@H1](C(=O)NC(C)(C)CCNC(=O)CC2=CC=C(C)C(OC)=C2)O1 CCCC=1N=COC=1C(=O)N[C@H1]2CN(C(=O)C(C)(C)CCCOC)CC(F)(F)C2 CSC[C@H1](C)C(=O)N(C)CCOCCCNC(=O)C1=CC=C2C(=C1)CC(=O)N2 CN=C1[NH1]C=C(C(=O)NCCC2CC(NC(=O)C=CC3=NC=CS3)C2)S1 O=C(C1=CC=NO1)N2CCN(CC3=CC=CC=C3F)CC2 CC[C@@H1]1CN(C(=O)C(F)(F)[C@H1](C)O)CC[C@H1]1NC(=O)CN2CCC3=CC=CC=C32 CCN1C=C(CC(=O)N[C@@H1]2C[C@@]23CCN(C(=O)[C@H1]4CCCN4C(=O)OC)C3)N=N1 C[C@@H1]1CCN(C2=NC3=C(C(=NCCC=4SC=CC=4Br)[NH1]2)CSC3)CC[S@]1=O C[C@H1](O)C(C)(C)NC(=O)C[C@H1]1CCC[C@@H1]1NC(=O)[C@H1]2C[C@@H1](O)C2 O=C(C[C@@H1]1CCCO1)NC23CC(CNC(=O)C=C[C@H1]4CCOC4)(C2)OC35CCC5 COC[C@@H1](C)[C@@H1](C)C(=O)N1CC2(CCN(C(=O)C(F)(F)C3=CC=CC(Cl)=C3)C2)C1 C=CCCCCCCCCC(=O)NC[C@H1]1CC[C@@H1](NC(=O)[C@@H1](O)CC(C)C)CC1 COC(=O)CCCONC(=O)[C@@H1]1CCC[C@@H1](NC(=O)C=2N=C(Cl)OC=2C)CC1 CCN(CCNC(=O)C[C@H1](C)P(C)(C)=O)C(=O)C1=N[NH1]C2=C1C[C@@H1](C(C)C)CC2 CCC1=C[NH1]N=C1CNC(=O)[C@@H1](CCNC(=O)C2=CC=CC(C3CC3)=C2)OC COC1(C(=O)NC[C@](C)(O)CNC(=O)C2=CC(Cl)=NN=C2O)CC(CF)C1 COC(=O)CC(C)(C)C(=O)NC[C@H1]1C[C@H1](NC(=O)C=CC2=CN(C)N=N2)C1(C)C [N-1]=[N+1]=NC1CCN(C(=O)C[C@@H1]2[C@@H1](NC(=O)CN=C3C=C[NH1]C=C3)C[C@H1]2O)CC1 CCCOC1=CC=C(C2=NC(C(=O)NC3=C(CC)C(C)=NN3C)=CS2C)C=C1C CC[C@](C)(F)C(=O)N[C@@H1](CNC(=O)CCCN1C=CC=N1)C2CCCCC2 C[C@H1]1CCC=2C(C(=O)NCC3(O)CN(C(=O)[C@H1](O)C4=CCCCC4)C3)=CSC=2C1 CC(C)(C)OC(=O)NCCC(=O)OCC(=O)N1CCN(C2=CC=CC=C2Cl)CC1 CCN1CCN(CC(=O)NC[C@H1]2CCN(C(=O)[C@@H1]3C[C@H1](C4=CC=CC=C4)O3)C2)CC1 C[C@H1]1CC[C@H1](C(=O)N[C@@H1](C)C2=CN=N[NH1]2)N(C(=O)C3=CC(F)=C[NH1]3)C1 CSC1=CC(C)=C(C(=O)NCCNC(=O)[C@H1]2[C@H1]3C[C@@]2(C4=CC=CC=C4)CO3)O1 CCC(C)(CC)C(=O)N1CCC(OCCNC(=O)C[C@@H1]2CCCC(F)(F)C2)CC1 COC1=CC=C(CC(=O)N(C)CCN2CCN(C(=O)[C@H1]3C[C@H1]3F)CC2)C=C1Br CN(CC(=O)N1CCC[C@@H1]1C(C)(C)CNC(=O)C2=C[NH1]C=C2Br)C3CC3 C[C@H1]1CCN[C@@H1]1C(=O)N2CCO[C@@H1](C3=CC=CC(C#N)=C3)C2 CCC(=O)N1CCC[C@H1](NC(=O)CC23CCC(CC2)OC3)CC1 CC=1SC(O)=NC=1C(=O)NC[C@H1]2C[C@@H1](O)CN2C(=O)CN3C=C(Br)C=N3 C[C@@H1](O)C(=O)N1CC=C[C@@H1](C(=O)N2CC3(COC(=O)C3)C2)C1 C[C@@H1](CCNC(=O)C1=COC(C2CC2)=N1)N(C)C(=O)CCC(N)=O CC(C)C1=CN=C(C2=CC=CC(NC(=O)N=C3C=C(CCO)O[NH1]3)=C2)O1 CCCC1=NC(C(=O)OCC2=NC3=CC=C(OC)C=C3S2)=CS1 CCN(C)CC(=O)N(CC(=O)NCCOCCCF)C1CC1 C#CCCOCC(=O)N1CC([C@@H1](O)C(=O)NCC2=CN=CS2)C1 CCC[C@@H1]1C[C@H1]1C(=O)N2[C@H1]3CC[C@@H1]2[C@H1](CO)N(C(=O)C4=CC=CO4)C3 CC[C@@]1(C(=O)N2C[C@@H1](C)[C@@H1](NC(=O)C3=CC=C4N=C(O)[NH1]C4=N3)C2)CC1(F)F CC(=O)C1=CC=CC(C(=O)N2CC=C[C@H1](NC(=O)[C@H1]3C[C@H1](N=[N+1]=[N-1])C3)C2)=C1 C=CCCOCC(=O)N1CC2(CCCC2)[C@H1]1C(=O)N[C@@H1]3C=CCCCC3 C[C@@H1](CC(=O)N1C[C@H1]2CC[C@H1]1C[C@H1]2NC(=O)C3=CC=NC=C3F)N4C=CN=C4 COC1=CC=C(C(=O)N[C@H1](CC(=O)N2C[C@H1](C)[C@H1](C)[C@H1]2C)CC3CC3)O1 CCC(C)(C)[C@H1](O)C(=O)NC1(CNC(=O)C2=CC=C(C#N)C(C)=N2)CCC1 CO[C@H1]1[C@H1](CNC(=O)C2=NOC=C2Cl)N(C(=O)C3CC4(CC(O)C4)C3)C[C@H1]1OC CC1=CC=C(C(=O)N2[C@H1]3CC[C@H1]2CN(C(=O)C[C@@H1]4CCNC4=O)C3)C(Cl)=C1 COCCC1=NC(=NC2CC3(CCN(C(=O)C=4C=NOC=4C)CC3)C2)S[NH1]1 CCC[C@@H1](NC(=O)CN(C(=O)[C@@H1](CC)NC(C)=O)C(C)C)C1CCC1 CC(C)(NC(=O)[C@]12CCC[C@H1]1N(C(=O)[C@@H1]3CCC3(F)F)CC2)C4=NC=CC=N4 CC1=C(Cl)C=CC=C1C(=O)N(C)C[C@H1]2CCCN2C(=O)[C@@H1]3CCN3C COCC1=NC(C)=CC(NC2(C)CCC(NC(=O)[C@@]34CCCC[C@@H1]3C4(F)F)CC2)=N1 N#CCC(=O)N1CC[C@H1]2[C@@H1]1CCCN2C(=O)C3=CC=C(Br)C(O)=N3 CO[C@@H1]1CC2=CC=C(S(=O)(=O)NCC3=CC=CC(CN)=C3)C=C2C1 C=CCC1(C(=O)NC[C@@H1](O)CNC(=O)C2=CC=NC(N3CCCCC3)=N2)CC1 C#CCC1(C(=O)NC[C@@H1]2CN(C(=O)[C@H1]3C[C@]3(C)Br)CCC24CCC4)CCCC1 C[C@@H1]1CN(C(=O)CC=2C=CSN=2)C[C@@H1]1NC(=O)CC3=CC=C(C(N)=O)C=C3 C[C@@H1](O)CC(=O)NC1C[C@@H1]2C(NC(=O)C=3C=NN(C(C)(C)C)C=3)[C@H1]2C1 COC(=O)CC1CC(C(=O)NC[C@H1](NC(=O)CN2N=NC(=O)[NH1]2)C(C)(C)C)C1 CO[C@H1]1C[C@@H1](CNC(=O)[C@H1](C)C2=CC=CC=C2C(F)(F)F)N(C(=O)C=C(C)C)C1 CCC(C#N)(CC)C(=O)N1CCO[C@@H1]([C@@H1](C)NC(=O)C2=CC=CC3=NSN=C23)C1 CC=1SC=NC=1CN2C[C@@H1]3C[C@@]3(C(=O)NC4=C(F)C=C(F)C=C4Br)C2 CC1=NN2N=CC=CC2=C1C(=O)NC[C@H1]3C[C@H1](NC(=O)C[C@H1]4C=CCC4)C[C@H1]3O CC1=CC(C(=O)N2CCC(CN(C)C(=O)[C@@H1]3C[C@@H1]3C(F)(F)F)CC2)=NN1C(F)F CC=1C=NN(CCC(=O)N[C@H1](C)CC(=O)N2CCC3(CC2)C[C@H1]3C#N)C=1 C=CC1(CC(=O)N[C@H1](CCC)CCCNC(=O)C2=NN(C)C(C)=C2Br)CC1 CSCC(C)(C)CNC(=O)[C@@]1(C)CCN(C(=O)C=2C=C(C)SN=2)C1 C[C@@H1]1CN(C(=O)[C@H1]2C[C@H1](O)C2)C[C@H1]1CNC(=O)C3(NC(N)=O)CC3 CN(C(=O)C(C)(C)C1=CC=CS1)[C@H1]2CCCN(C(=O)CC[C@H1]3CCCO3)CC2 C#CC1=CC=C([C@@H1]2C[C@H1]2C(=O)N(C)CCC3=CC=CC4=CC=CC=C34)C=C1 COC1=CC=C2C(=C1)CC[C@@H1](C(=O)N[C@@H1](CNC(=O)CC=3C=COC=3)C(C)C)C2 C[C@H1](NC(=O)[C@@H1]1CCN(CC2=CC=C3C=CC=CC3=C2O)C1)C(F)(F)F COC=1SC=CC=1C(=O)NC[C@H1]2C=C[C@@H1](NC(=O)C[C@H1](C)C3=CC=CO3)C2 CC(C)C1=CC(C(=O)N2CC[C@@H1](NC(=O)/C=C/C(F)(F)F)C[C@@H1](O)C2)=CC(O)=N1 CC(C)COCCC(=O)N1CC[C@]2(C[C@H1](NC(=O)C3CC=CC3)CO2)C1 CCCCC[C@H1](CC)C(=O)NC[C@@H1](O)CN(C)C(=O)C1(COC)CCCC1 NC1=CC=C(Br)C(C(=O)NC[C@H1]2CSCCN2C(=O)CC(F)F)=C1 O=C(NC1C[C@@H1]2CCC[C@H1](C1)N2C(=O)CC3=CC=CC=C3)[C@H1]4CCCCS4(=O)=O CCCC[C@H1]1CCCN(C(=O)C2(NC(=O)[C@H1]3CCCCO3)CSC2)C1 C=CCSCC(=O)N[C@@H1](C)CN1CCN(C(=O)COCCC2=CC=CC=C2)CC1 CCOC(=O)C1(NC(=O)N[C@H1](C)CC=2C=CC3=N[NH1]C=C3C=2)CC(OC)(OC)C1 CO[C@@H1](CCNC(=O)C1=CC=NC(C(F)F)=C1)CNC(=O)C[C@H1](C)[C@@H1]2CCCO2 CC1=C(Cl)C=CC=C1NC(=O)[C@@H1](C2=CN=C(Br)S2)N(C)CC3=CC=C(Cl)C=C3 O=C(NCC[C@H1]1CCCN1C(=O)CNC(=O)C2CC2)C3=CN=C(C(F)(F)F)S3 COC1=CC=CC(F)=C1C(=O)N2CC[C@H1]3[C@@H1](C2)CN3C(=O)CC=4SC=NC=4C C#CC[C@@H1](O)C(=O)NC[C@H1](CO)CNC(=O)C(C)=CC1=CC=CO1 O=C(CCC1=CC=C(OC(F)(F)F)C=C1)N[C@H1]2[C@@H1]3CN(C(=O)C=C4CCC4)C[C@@H1]32 O=C(CCN=C1[NH1]C=CS1)NC[C@@H1]2CCN2C(=O)CO CCOC[C@@H1](O)CNC(=O)[C@@H1]1CCC[C@@H1]1NC(=O)CN2CC3=CC=CC=C3C2=O COCC1=C(C)C=CC=C1NC(=O)N[C@@H1]2[C@H1](O)[C@@H1]3C[C@H1]23 CCCCCCCC1=CN(C[C@@H1]2CCN2C(=O)[C@@H1](C)COC)N=N1 C=CC1=CN=CC(C(=O)N2C[C@H1](CNC(=O)C3(O)CCC3)[C@H1](C(F)(F)F)C2)=C1 CC1(C)COCC[C@H1]1C(=O)N2CCN(C(=O)C=C3CCCCC3)[C@H1]4CC[C@H1]42 CC(C)C1=NC(C(=O)N2[C@H1]3CC[C@H1]2[C@H1](CNC(=O)C4=CC=5OC=CC=5S4)C3)=CO1 CCCCC[C@@H1](O)C(=O)NCCC[C@H1](CCC)NC(=O)CCCS(C)(=O)=O C=CCCONC(=O)[C@@H1]1CCC[C@H1](NC(=O)[C@@H1](CC)N(CC)CC)CC1 CCN1N=CC=C1C(=O)N2CCC(CCCCCNC(=O)[C@H1]3CCOC3)CC2 CC[C@@H1](F)C(=O)NCC1(C2(O)CN(C(=O)C[C@H1](C)N3N=C(C)C=C3C)C2)CC1 COC1=CC=C2C(=C1)C[C@@H1](C)N2C(=O)N3CC[C@](C)(C4CC4)C3 CC[C@@H1](O)C(=O)N1CCN(C(=O)C2=CC=C(C(F)F)N=C2)[C@@H1](CC(=O)NC)C1 CCC=1N=COC=1C(=O)N2C[C@@H1]3CCN(C(=O)CS(N)(=O)=O)[C@@H1]3C2 CCC[C@H1](C(=O)N1CCCC12CCN(C(=O)CCCN3C=CC=C3)CC2)N(C)C CC=1OC=CC=1CC(=O)NC2CC(C)(NC(=O)[C@@H1](O)CN3CCCC3)C2 O=C1NC[C@@H1](CC(=O)N[C@H1]2C[C@@H1]3C[C@H1]2C[C@@H1]3C(=O)N[C@@H1]4C[C@H1]5C[C@@H1](CO)C[C@H1]54)O1 CNS(=O)(=O)CC(=O)N[C@H1](CNC(=O)C(C)(C)C(=O)N(C)C)[C@@H1]1CCOC1 C=CC[C@H1](CNC(=O)[C@H1]1CCN(C)C[C@H1]1C=2C=NN(C)C=2)NC(=O)C(C)(F)F C[C@@H1]1C[C@@H1](C)N(C(=O)C2=CC=NC=3C=C[NH1]C2=3)C[C@H1](C)O1 CCCN(CCNC(=O)C1(F)CCCC1)C2=NC(OC)=CC(OC)=N2 CC(C)CN(CC(=O)N[C@@H1]1[C@H1]2CC[C@H1]3[C@@H1](C2)C[C@H1]31)C(=O)C4=CN=NN4C O=C(N[C@]12CCC[C@H1]1N(C(=O)C3=CC=CC(Cl)=N3)CCC2)C4=CC=NN4C(F)F CC1=NC=C(F)C(N(C)C[C@H1]2CCCCN2C(=O)[C@@H1]3CCCN3N=O)=N1 CC(C)C(C)(C)C(=O)N[C@H1]1C[C@@H1](F)CN(C(=O)[C@]2(C)CC(C3CC3)=NO2)C1 CCC1(C(=O)N[C@H1]2CCCC[C@H1]2CNC(=O)[C@H1]3CC(=O)CO3)COC1 CO[C@@](C)(C(=O)N1C[C@H1]2[C@H1](CC(=O)N[C@@H1]3[C@H1]4COC[C@H1]43)[C@H1]2C1)C5(C)CC5 C[C@H1]1CN(C(=O)NCCC2=CC=C(S(=O)(=O)N3CCOCC3)C=C2)CCC1(F)F CCN(C[C@@H1]1CCCN1C(=O)CNC(=O)[C@H1](C)CO)C(=O)C[C@H1]2C=NN(C)C2=O CN1CC(C(=O)N2C[C@H1](NC(=O)C(C)(C)O)C[C@@]23CCOC3)C1 C[C@@H1]1CN(C[C@@H1]2CCC(=O)N(C(=O)C[C@@H1]3CCSC3)C2)C[C@H1](C)O1 CC(C)CC1(CNC(=O)[C@@H1](CCN(C)C)NC(=O)CCC(N)=O)CC1 CCC[C@@H1](C)C(=O)N1CCN(C(=O)C=2C=NN(C)C=2CC(C)C)C[C@H1]1C CN(C)[C@H1](CO)C(=O)N[C@@H1]1CN(C(=O)C2(N3N=CC=N3)CCOCC2)CC[C@H1]1O CCN1N=CC2=CC(C(=O)NCC3(F)CN(C(=O)[C@H1](O)C=4C=CSC=4)C3)=CN=C21 CCCC(CCC)CCNC(=O)[C@H1]1CC[C@H1](O)CN1C(=O)C[C@@H1]2C[C@H1](O)C2(C)C NC1=CN=CC(C(=O)N2C[C@@H1]3C[C@H1]4C[C@H1]3[C@@H1]2[C@H1]4NC(=O)[C@H1]5C[C@@H1](OC(F)F)C5)=C1 CCC=1C=C(C(=O)NCCN(C(=O)[C@H1](CO)NC(=O)C(C)C)C2CCCC2)ON=1 CCC[C@H1](CO)NC(=O)C1=CC=CC2=C1OC(C)(C)O2 CC1(C#CC(=O)NC[C@H1](NC(=O)C2=CC=CC(O)=N2)C3CC3)CC1 CC=1C=C(C(=O)N[C@H1]2C[C@@H1](C(=O)NCC=3C=C[NH1]N=3)C2(C)C)OC=1C CCC1=CC(C(=O)N[C@@H1](CC)CNC2=NC(Cl)=NC=3SC=CC2=3)=C(C)O1 CCC[C@@H1](NC(=O)[C@@H1](C)OCC1CC1)C(=O)NC[C@@]2(C)CNC(=O)O2 CCC12CN(C(=O)C=3C=CSC=3OC)C(CNC(=O)C[C@H1](O)C4CCCC4)(C1)C2 CO[C@H1](C)C(=O)N[C@H1]1CC12CCC(NC(=O)C3=C(C)C=CC=C3F)CC2 CC1=C(C(=O)N[C@@H1](C)C[C@H1](C)NC(=O)C2=CN=C(S)[NH1]2)C=CN1C C=CCCC(F)(F)C(=O)NCC[C@@]12CC[C@H1]1CN(C(=O)C=3C=NN4C=3CCC4)C2 CSC1(C(=O)NC[C@@H1](NC(=O)C2=COC3=C2[C@H1](O)CCC3)C4CCC4)CC1 CCN1CCCC[C@H1]1CNC(=O)[C@H1]2C[C@@H1]2C3CN(C(=O)CC(=O)OC)C3 C[C@H1]1CN(C(=O)C=2N=N[NH1]C=2Cl)CC[C@@H1]1NC(=O)/C=C/C3=CC=C(F)C=C3[N+1](=O)[O-1] CSCC1(C(=O)N2CC[C@@H1]([C@H1](C)NC(=O)C3=CC(C)=NN=C3O)C2)CC1 CC1=C(C(=O)N2CC[C@H1](OCC(=O)N(C)C[C@@H1]3CCOC3)C2F)COCC1 CC(=O)N[C@@H1](CC(=O)NCCNC(=O)C[C@H1]1CC1(Cl)Cl)C2=C(Cl)C=CC=C2Cl C[C@H1]1CN(C(=O)C2=CC=CC3=C2CCC(=O)N3)C[C@H1]1NC(=O)CC4(C#N)CCC4 CC(C)C[C@@H1]1CC[C@@H1](NC(=O)[C@@H1]2CC=C[C@@H1](N3C=C(C=4C=C[NH1]N=4)N=N3)C2)C1 CCC1=CN=CC(C(=O)NC[C@@](C)(NC(=O)C2=CC=CC(SC)=C2)C3CCC3)=C1 CN1N=CC(C(=O)NCC(=O)N2CCN(C(=O)C3=CC=CC(N)=C3)CC2)=C1C#N CC1=NC=C(CCNC(=O)[C@@H1](NC(=O)C2=NN(C)C=C2C)C3=CC=NN3C)S1 O=C(CN1C=NC=N1)N[C@H1]2CC[C@](F)(CNC(=O)C3=CSC4=NC=NC(O)=C34)C2 CCCN1N=CC=C1C(=O)N(CC)CCNC(=O)C(=CC2=CC=CS2)C3CCCC3 CO[C@H1]1CN(C(=O)C2=C(C)N=C(O)N=C2C)C[C@@H1]1C(=O)N[C@H1](CC3CC3)C4CC4 CC(C)[C@@H1](CNC(=O)C(C)(C)C1=CC=NO1)NC2=NC=C3C=CN=C3[NH1]2 C[C@H1](OC[C@H1]1CCCCO1)C(=O)NCC2(CN(C)C(=O)[C@H1]3CCNC3=O)CC2 O=C(N[C@H1]1C=CCN(C(=O)[C@H1]2CC[C@H1]3C[C@H1]3CC2)C1)C4=N[NH1]C5=C4COCC5 CNC(=O)CC(=O)NCC1(N=C2[NH1]C(C3CC3)=NC(Cl)=C2C)CCOCC1 CC1=CN(CC(=O)N[C@H1]2CCCN(C(=O)C3C[C@@H1]4COC[C@H1]4C3)C2)C(=O)N=C1O CC1=CC(C(=O)N2CC[C@H1](C)[C@H1](NC(=O)CN3CCCCCC3=O)C2)=NC(O)=N1 CC1=CC(=NC(=O)C(=O)N2CCC[C@@H1]2CN(C)C(=O)CSC[C@@H1]3CCCO3)[NH1]O1 O=C(NCCCNC(=O)C[C@](O)(C1=NC=C[NH1]1)C(F)(F)F)C2=CC=C(CO)N=C2 CCC1=C(C(=O)NC[C@]2(C)CCN(C(=O)CN3CCC[C@@H1]3CO)C2)C=NN1CC CC(C)CCO[C@@H1](C)C(=O)NCCNC(=O)C1(C2=CC=CC=C2Br)CCC1 CCN(CC)C(=O)CCC(=O)NC(C)(C)[C@@H1](C)NC(=O)C(=O)NCCNC(C)=O CN(CCOCCNC(=O)C#C[C@]1(C)CCCO1)C2=NC=C3SC=C(Br)C3=N2 CCN1N=CC(C(=O)NC[C@@H1](NC(=O)CC2=CN=CS2)C3CCC3)=N1 CC[C@@H1](CC(=O)N1CCCC[C@H1](NC(=O)C2=C[NH1]C(=N)N=C2C(F)(F)F)C1)SC C=C[C@@H1]1CC[C@H1]1C(=O)N2CCC[C@H1](CCNC(=O)CCCC3=NC=CS3)C2 O=C(NC[C@@H1]1CCN(C(=O)C[C@H1]2CCCC3=CC=CC=C32)C1)C4=CSCS4 C[C@H1](CC1CC1)C(=O)N2CCN(C(=O)C=CC=3C=C[NH1]N=3)[C@@H1]4CCC[C@@H1]42 O=C(CN1C(=O)CNC1=O)NC[C@H1]2CC[C@H1](C(=O)NCCN3CCNC(=O)C3)C2 O=C(CCC1=NN=CS1)NC2(CNC(=O)C=3N=COC=3[C@@H1]4CCCO4)CCCC2 C1=C=CCC(=O)NCC[C@@]1(CO)NC(=O)[C@H1]2CCCCN2S(=O)(=O)C=CC=C(C(C)=O)C=CCC CCCN1CCC[C@H1](C(=O)N[C@@H1]2C[C@H1]3CC[C@@H1]([C@H1]2C)N3C(=O)CNC(=O)NC)C1 CC1=C(Cl)C=CC(C(=O)N2CC[C@@](O)(CNC(=O)C3(C4CCCCC4)CC3)C2)=C1 CC[C@@H1](CC1=CC=C([N+1](=O)[O-1])C=C1)C(=O)N[C@H1]2CC[C@H1](NC(=O)[C@@H1](O)C(F)F)C2 CCCN1CCN(C(=O)C2=NO[C@H1](CNC(=O)C3=N[NH1]C4=C3CCC4)C2)CC1 CC1=NN=C(CC(=O)N[C@@H1]2CCO[C@H1](C3CCN(C(=O)C=CCF)CC3)C2)S1 C[C@@H1](CF)C(=O)N(CCNC(=O)CC1=CC=CN=C1N)C2CCCC2 CC1=COC=C1C(=O)N[C@@H1]2CCC[C@H1](CC(=O)N3C[C@@H1](C)[C@@](C)(CO)C3)C2 CN(C)CC1(CNC(=O)[C@H1]2CC23CCN(C(=O)[C@@H1]4CCC(F)(F)C4)CC3)CC1 C[C@@H1](C(=O)N1CC(O)(C2(CNC(=O)[C@@H1]3CCO3)CC2)C1)C4=CC=C(F)C=C4 C=C(CCNC(=O)C1=CN=C2[NH1]C(C)=NC2=C1)CNC(=O)[C@@H1](OC)C3CCCC3 CC1(NC(=O)CC2=C[NH1]C3=CC=CN=C23)CCN(C(=O)C4=C(Cl)CCCC4)CC1 CCCCC(=O)N[C@H1]1CN(C(=O)[C@H1](C)NS(=O)(=O)C2=CC=C(C)C=C2)C(C)(C)C1 C#CC[C@](C)(NC(=O)C[C@H1]1CCOC1(C)C)C(=O)N[C@@]2(C)C[C@H1]3CC[C@@H1]2C3 CN1N=CC(C(=O)O)=C1C(=O)N2CC(CC3=CC=C(F)C=C3F)C2 CC1(C)C[C@H1](CNC(=O)[C@@H1]2CC3(CCC3)CO2)N(C(=O)[C@@H1]4C[C@@H1]4F)C1 C=CC=CCC(=O)N[C@H1](CNC(=O)C1=C(Cl)C=CC(F)=C1F)C2CCCCC2 CC1=CC=CC(CNS(=O)(=O)CCCCS(=O)(=O)N[C@@H1]2CC[C@]2(C)CO)=C1 CCN(CC(N)=O)C(=O)CCCCN(C)C(=O)C1=CN=C2N1CCC2 O=C([C@H1]1CCCN(C(=O)C2(C(F)(F)F)CC2)C1)N3CC[C@H1](N4C=CN=C4)C3 C[C@@H1](NC(=O)C1=CC(Cl)=C[NH1]1)C(=O)NC[C@@]2(C)CC2(F)F CC[C@H1](F)C(=O)NC(C)(C)CNC(=O)C1=CC2=C(Cl)C(Br)=CC=C2S1 CC(C)=C(Br)C(=O)N1CCC[C@@]2(CCN(C(=O)C3=CC(Cl)=NC(N(C)C)=C3)C2)C1 CC1=NO[C@](C)(C(=O)N[C@@H1]2CN(C(=O)C3=NC(C4CC4)=CS3)CC5(CCC5)C2)C1 COCCC(C)(C)CC(=O)N1CCN(C(=O)C2=CC=C(N)C(C)=C2C)[C@@H1]3C[C@H1]31 O=C(CC1=CC(Br)=CC=C1F)NC[C@H1]2C[C@@H1]2NC(=O)C3=CN=NC(O)=C3 BrC1=CN=CN=C1N2CC(OCCCOC3=CC=CC4=C3OC5=CC=CC=C54)C2 COCCCCC(=O)N[C@H1](C)C1(O)CCN(C(=O)C2=C[S@](=O)CCC2)CC1 CC=1N=C(C(=O)NC[C@H1](CO)CNC(=O)[C@H1]2C[C@@H1](C3=CC=CC=C3)C2)SC=1C O=C(N[C@]1(C2=CC=CC=C2)CCN(C(=O)C3CC4=NC=CN=C4C3)C1)[C@@H1]5C[C@@H1]5F CN1N=NC=C1C(=O)N2C[C@H1](NC(=O)C3=CC(Br)=NN3C)[C@H1]4C[C@H1]42 C=C(C)CC(=O)N1CC[C@@H1](N(CCO)C(=O)C[C@@H1](O)C2=CC=CC=C2)C1 C=CCO[C@@H1](C)C(=O)N1CCCC2(CC(NC(=O)C3=CN(C)C=C3C)C2)C1 CC(C)[C@@H1](NC(=O)[C@H1]1CCCS[C@H1]1C)C(=O)N2CCC3(CSC3)C2 O=C1CC[C@@H1](C(=O)NCC2CCC3(CC2)CCN(C(=O)C4=CSC(Cl)=N4)CC3)C1 CC(C)[C@@](C)(O)C(=O)N(C)C[C@H1](C)NC(=O)C1=CC=C(OC2CCCC2)C=C1 CC(C)S[C@@H1](C)C(=O)NCC1CC2(C1)CC(NC(=O)[C@H1]3CCCC[C@@H1]3C4CC4)C2 CC1=CN=CC(/C=C/C(=O)NCC[C@@H1](CNC(=O)C2(C#N)CC3(CC3)C2)C)=C1 CC1=CC(O)=C(Cl)C=C1C(=O)N[C@H1]2C[C@H1](NC(=O)CC3=C(Cl)C=CC=C3Cl)C2 CC[C@@]1(C(=O)N2C[C@H1](C(=O)N3CCC(CCO)CC3)CC(C)(C)C2)CCOC1 O=C(NCCO[C@H1]1CCN(C(=O)C2=CSC(Cl)=N2)C1)C3=COC(C4CCC4)=N3 CC(=O)N1CC(C(=O)N(C)CC[C@H1](NC(=O)C[C@@H1](C)C2=CC=CC=C2)C(C)(C)C)C1 COC1=CN(C)N=C1[C@@H1](C)NC(=O)C2=CC3=C(C)C=C(F)C=C3[NH1]2 CCC1=CC(C(=O)NC2CCC3(CC2)C[C@H1]3NC(=O)[C@H1](C)C4=CC=CO4)=N[NH1]1 CC(C)(C)C[C@@H1](C(=O)NC1CCCCC1)N2CC3=CC=CC=C3O[C@]4(CCOC4)C2 C[C@@H1](CNC(=O)CN1C=C(C2=C(F)C=C(F)C=C2F)N=N1)CN(C)C(=O)C(F)F O=C(NCCN1C(=O)CCC1=O)[C@H1](F)C2CCN(C(=O)C34CCN(CC3)C4)CC2 CC1(C)CC[C@H1](CNC(=O)CCN(CC2CC2)C(=O)CCCN3C=CC=C3)OC1 CCSCC(=O)NCC1(O)CC(N=C2N=C(OC)C=C(OC)[NH1]2)C1 CC1=NO[C@H1](C(=O)NCC2=NC(CNC(=O)C[C@]3(C)CCCO3)=CS2)C1 CON(CCC(=O)N[C@H1]1C[C@H1]2COC[C@H1](C2)C1)C(=O)CSCCC#N C[C@H1]1C[C@@H1](C(=O)N[C@H1]2CCN(C)C[C@H1]2C)N1C(=O)CSCC(N)=O CC(C)[C@H1](C(=O)N[C@H1]1C[C@](C)(NC(=O)[C@@H1](F)CC2CC2)C1)N3CCCS3(=O)=O CN(NC(=O)CCCCCCC(C)=O)C(=O)OC(C)(C)C CC1=NC=CN1CCNC(=O)C[C@@H1]2CC3(CC3)CN2C(=O)C=4SC=CC=4Cl O=C(NC[C@H1]1CCC[C@@H1](NC(=O)[C@H1]2CCCC2(F)F)C1)C=3C=C[NH1]C4=NC=CC=34 O=C([C@@H1](O)C1CCC1)N2CCC[C@@H1]2CN3C=C(C4CC5(CC(C(=O)O)C5)C4)N=N3 CC=1C=NOC=1C(=O)N[C@H1]2CC23CCC(NC(=O)[C@H1]4CCC5=CC=CN=C54)CC3 C#CC[C@]1(C(=O)NC[C@H1]2COCCN2C)CCN(C(=O)[C@H1](C)COCC)C1 CC1(C)C(=O)C[C@H1]1C(=O)NC[C@H1]2C[C@@H1](C(=O)N3CC4(CCNC4=O)C3)C2 C[C@]1(C(F)F)C[C@H1]1C(=O)N2CC([C@@H1](O)C(=O)NCCC3=CC=CC=C3)C2 CCC1=NC(C(=O)NCCC(C)(C)NC(=O)C2=NC=C(Cl)C(N)=C2Cl)=CS1 O=C(NC1CCC2(CC1)CN(C(=O)C=CC(=O)NC3CC3)C2)[C@@H1]4C[C@@H1]4Cl CCCC(=O)NCC[C@@H1]1CN(C(=O)C2C[C@H1]3COC[C@@H1]3C2)CCO1 CC(C)(C(=O)N1CC[C@@H1](O)[C@H1](NC(=O)C2=CC=C(C3=NC=CS3)C=C2)C1)C(F)F CNC(=O)NCCC(=O)N1C[C@@H1]2C[C@H1]3C[C@H1]2[C@H1]1[C@@H1]3NC(=O)CCCCCOC CCC[C@@H1](NS(=O)(=O)C1=CN=CC=C1N2CC[C@H1](CS(C)(=O)=O)C2)C3CCCC3 CC1=CC(=NC(=O)N2CCC[C@H1](C3CCC3)C2)C=C(C)[NH1]1 CCC1=CC=C(C2=CC=C(C3=NC=CN3CC4OCCCO4)C=C2OC)S1 O=C(CCOCC(F)F)NC1(CNC(=O)[C@@H1]2CC[C@@H1](C(F)(F)F)C2)CCCC1 CCOC=CC(=O)NC[C@H1]1[C@H1]2CCC[C@H1]1N(C(=O)C3=COCCC3)C2 CC(=O)NC1=CC=C(Cl)C(C(=O)NC[C@H1]2C[C@@H1](NC(=O)[C@@H1](C)CC3CCC3)C2)=C1 COCCOCC1=CC=C(CNC(=O)C(=O)N[C@@H1]2CC[C@H1](C3=CC=C(Cl)C=C3)C2)O1 COC(=O)[C@](C)(NC(=O)[C@H1](O)COCC1=CC=CC=C1)C2=CC=CC([N+1](=O)[O-1])=C2 C[C@H1]1C[C@@H1](NC(=O)CC2=CC=C3C(=C2)CC3)CN1C(=O)C4=CN=C5C=CC=CN45 CC[C@@H1](CNC(=O)[C@H1]1CCOCC1(C)C)NC(=O)C=2SN=NC=2C CCN1CC(NC(=O)C[C@@]2(C)CCN2C(=O)C3=NC=CN3C(C)C)C1 CCCC(C)(C)CC(=O)N[C@@H1](CC=1C=C[NH1]N=1)C(=O)NCC=2C=COC=2 NC1=NC=CN=C1C(=O)N[C@H1]2CC23CC(NC(=O)CSCCC(F)(F)F)C3 C=C[C@@H1](C)C(=O)N1CCC[C@](O)(CCNC(=O)C2=CN=CC(N)=C2)C1 COC1=CC=C(CNC(=O)[C@]2(C)CCN(C(=O)C3=CC=C(OC)C=N3)C2)C=C1Cl CCC1=C(C(=O)NC(CC)(CC)CNC(=O)CC2=CC(O)=NC(O)=N2)CCCO1 CC[C@@H1](C)NC(=NCC1=C(O)C=CC=C1F)NCC2(C(=O)OC)COC2 CSC=1C=C(C(=O)N(C)C[C@@H1](C)CNC(=O)COC2=CC=C(Cl)C=C2F)OC=1C CCN(C(=O)C1CS(=O)(=O)C1)[C@@H1]2CCCN(C(=O)[C@]3(F)CC=CCC3)C2 CC=CCCC(=O)N1CCC[C@H1](N2CCN(C(=O)C[C@H1](C)N3C=CC=C3)CC2)C1 NC1=C(Cl)C=CC(C(=O)N2CC[C@H1](C(=O)O)[C@H1](C3=CC=CC=C3)C2)=C1Cl N=CN=C(O)C(C(=O)NC[C@H1](O)CNC(=O)C1C[C@H1]2C[C@@H1](C1)CS(=O)(=O)C2N)=C[NH1] CC(C)C[C@@H1]1C[C@H1](C(=O)N[C@H1](C)C2CN(C(=O)[C@]3(C)CC3(F)F)C2)CC(=O)N1 CC=1OC(Br)=CC=1C(=O)N[C@H1](CNC(=O)CCN2CCCCCC2)CC(C)C CC(=O)C=1C=CSC=1C(=O)N[C@@H1]2C[C@H1](O)CN(C(=O)C3=CC=CC=4SN=CC3=4)C2 C[C@@H1](CCNC(=O)[C@@]1(C)COC(=O)C1)NC(=O)CCCCC2=CN=N[NH1]2 CCN1CCO[C@H1](C(=O)N2CCN(C(=O)C3=CSN=N3)C[C@H1]2C)C1 CC1=C[NH1]C(C(=O)NC[C@@H1]2C[C@H1]2NC(=O)CC3(N4CCOCC4)CCCC3)=C1 CC(C)N1N=CC=C1C(=O)NC2CC3(CCN(C(=O)[C@@H1]4CC45CCCC5)C3)C2 C#CCC[C@H1](O)C(=O)N[C@H1](CCOC)CNC(=O)C1(C(C)C)CCC1 CC=1C=COC=1C=2N=C(C3=CC=CC(C4=CC=NN4C)=C3)N(C[C@@H1]5CCOC5)N=2 C#CC1=CN(C)N=C1C(=O)NC[C@H1]2[C@@H1]3C[C@H1]2CN3C(=O)C4(CC5CC5)CC4 C=C[C@@H1](NC(=O)[C@@H1]C1CCN(C(=O)[C@@H1]2CC(=O)CC23CCC3)CC1)C(F)(F)F O=C(NC[C@H1]1C=CCN1C(=O)C2=CC=C3C(=C2)CCOC3)C4=C(O)C=CC=C4Cl C=CCO[C@H1](C)C(=O)NC[C@@H1](C)CNC(=O)CC1CCN(C)CC1 CC1=CC=C(C(=O)N2C[C@@H1](CC(=O)N[C@H1]3COC[C@H1]3F)CC2(C)C)S1 CN1C(=O)C(CN[C@H1]2CCCC3(C2)OCCO3)=NC4=CC=CC=C41 CCC[C@H1](OCC)C(=O)N1CC(C)(C)C[C@@H1]1CC(=O)N[C@H1]2C[C@@H1](N3CCCC3)C2 O=C(OCC=1C=CN(CCC(F)(F)F)N=1)C2CCC3(CCC3)CC2 CN(C)C1(CC(=O)NC[C@@H1]2CN(C(=O)C3=CN=N[NH1]3)CC2(C)C)CCCC1 CC1=CC=C(CSCCNC(=O)C2=CN=CN(C)C2=O)C=C1 C#CC1=CC=C(C(=O)N2C[C@H1](C=C)[C@H1](NC(=O)C3=CC=C(C4CC4)N=C3)C2)C=C1 CC=1SC=C(C(=O)N2CC[C@@H1](C(=O)N(CC3CCC3)[C@H1](C)CO)C(C)(C)C2)C=1C CCCCSCC(=O)N[C@@H1]1CN(C(=O)C=2C=CSC=2C)[C@@]3(CCOC3)C1 CC1=CC([N+1](=O)[O-1])=NC=C1C(=O)NC2CC(CCNC(=O)C[C@@H1]3OCC[C@@H1]3C)C2 CO[C@H1](CC1CCC1)C(=O)N2CCCC[C@@H1]2C(=O)N[C@H1](CC3CC3)C4CC4 CC[C@H1](CNC(=O)C1=CC2=C(F)C=CC(Br)=C2[NH1]1)NC(=O)C3=CN=C[NH1]3 O=C1C[C@H1](C(=O)N2C[C@@H1](NC(=O)CN3C(=O)CCC3=O)CC4(CCC4)C2)CN1 CO[C@@H1](CNC(=O)C1(N(C)C(=O)[C@@]23CC[C@@H1](C2)O[C@@H1]3C)CC1)C4CCCC4 C[C@@]12CN(C(=O)C=C(Cl)Cl)C[C@@H1]1CN(C(=O)C3=CC(C(F)F)=CS3)C2 CC=1SC=NC=1C(=O)N(C)[C@@H1]2CN(C(=O)C3=CC=C(OCCO)C=C3)CC24CC4 CCCC[C@@H1]1CCC[C@H1]1NC(=O)C2=CC=C(CNC(=O)C3=NC=CN3CC)S2 CP(C)(=O)[C@@H1]1CCC[C@H1]1C(=O)N[C@H1]2C[C@H1](CNC(=O)C3=NC=CN4N=CC=C34)C2 CCCCCCCCCC=CC(=O)NCC[C@H1]1C[C@H1](NC(=O)[C@H1]2CCNC2=O)C1 C12C3=CC(C(=O)NC[C@@H1]CC[C@@H1](NCBr)[C@H1]3C1)=NO2 CC[C@@H1](CC(F)F)C(=O)N(C)CCCNC(=O)CCNC(=O)C1=CN=CC=N1 CN(C(=O)C(=O)N1CCC(C(F)(F)F)CC1)C2=CC(Cl)=CC=N2 C[C@H1](C(=O)N(CCNC(=O)C=1SC=CC=1Cl)CC2=CC=CC=C2)N3C=CC=N3 CC=1N=NN(CC(=O)N2CC(F)(F)C[C@@]2(C)CNC(=O)C[C@@H1]3C=CCC3)N=1 CC#CC[C@@H1](C)NC(=O)C(=O)NC1=CC=CC=C1F C[C@@H1]1C[C@H1](N=C2[NH1]C(Cl)=C(C#N)S2)CN1C(=O)CC=3N=C4N=CC=CN4N=3 CC1=C(F)C=CC(C(=O)N2CCC[C@@H1](CCNC(=O)C[C@H1]3CCOC3=O)C2)=C1Cl O=C1CC(C(=O)NC[C@H1](NC(=O)C(F)=C2CCC2)C3CC3)=NN1 COC=1C=C(CN(C)C2=NC=NC(N[C@H1]3CC4=CC=C(C#N)C=C4C3)=C2C)SN=1 COC1=CC=C(C(=O)NC2CC3(CCN(CC4=CC=CC=C4Cl)C3)C2)C=C1F C[C@H1](CCNC(=O)[C@H1]1CC[C@H1](N(C)C)CC1)N(C)C(=O)C[C@H1]2CCCCN2C CCC1=NC=C(C(=O)NC[C@@H1](CN(C)C(=O)OC(C)(C)C)C2(CC2)C)[NH1]1 CC[C@H1](C)[C@H1](O)[C@H1](C)C(=O)N1CC=C[C@@H1](C(=O)N2[C@H1]3CC[C@H1]2COC3)C1 CC(=CC(=O)N1C[C@H1](O)C[C@@H1]1CNC(=O)[C@]2(C)C=CCC2)C(C)(C)C CCOC1=CC=C(C(=O)N2CCO[C@H1](CNC(=O)C=CCN3CCCC3)C2)C=C1 CN1C=C(C(=O)N2CC[C@@]3(COC[C@H1](CNC(=O)CC(F)F)O3)C2)N(C)C1=O N[C@@H1](C(=O)NC1(CCO)CC1)C2=CC=CC=N2 C[C@@H1](NC(=O)[C@@H1]1CC2=CC=CC=C2NC1=O)C(C)(C)NC(=O)C3=COC(Cl)=N3 CN(CC1CCN(C(=O)CC2=CN=NN2C)CC1)C(=O)[C@]34C[C@H1]3CN(C)C4 CCN1C=CC(C(=O)NC[C@H1]2CCC3(CO2)CC(NC(=O)CCOC)C3)=CC1=O CC(C)C(=O)NC1=CC=CC(C(=O)C=CC2=CC(C3CC3)=CC(Cl)=C2[N+1](=O)[O-1])=C1 CCC[C@@](C)(O)C(=O)N(C)C[C@H1](O)CN(C)C(=O)C=CC1CCCC1 COC1=CC=C(CC(=O)N2CCC[C@H1]([C@H1](C)NC(=O)CCCN=[N+1]=[N-1])C2)C(F)=C1 CC=CCCC(=O)N1CCN(C(=O)[C@@H1]2[C@H1]3[C@@H1]4CC[C@@H1](C4)[C@H1]32)[C@H1](C(F)F)C1 CC1=CN=C(C=CC(=O)NC2(CNC(=O)[C@H1]3CCC=4N=N[NH1]C=4C3)CCC2)[NH1]1 CCOC1=CC=C(Cl)C(C(=O)N[C@H1](C)CCNC(=O)C2=CC(OC)=NC=N2)=N1 CCOC1CC(C(=O)N2CCC(OCCNC(=O)C3=C(SC)C=NN3C)CC2)C1 CCC1(C(=O)N[C@@H1]2COC3(C2)CN(C(=O)[C@H1]4CCC(=O)C4)C3)CC1 COC(=O)[C@@H1]1C[C@H1]1C(=O)N2CCC[C@@](C)(CNC(=O)C3=CC([N+1](=O)[O-1])=CN3C)C2 CO[C@H1]1C[C@H1](CNC=2[NH1]C(=N[C@H1]3C[C@H1]4CCCCCC[C@@H1]34)N=C5SC=NC=25)C1 C[C@]1(C(=O)N2CC[C@@H1](NC(=O)CC3=CN4C=C(F)C=CC4=N3)[C@@H1](O)C2)C=CCC1 C[C@H1]1CC=CC[C@@H1]1C(=O)NCC(C)(C)C#CC(=O)N[C@H1]2CN(C)CC23CC3 O=C(CN1C=CN=C1)N2CC[C@@]3(CCCN3C4=NC(C5CC5)=NC6=CC=CC=C46)C2 COC1=CSC(C(=O)N[C@H1]2CC[C@@H1](CNC(=O)C=C(C)C)C2)=C1 CC1=NC(C=CC(=O)N[C@H1]2C[C@H1](NC(=O)C3=CC=C(N4C=NN=N4)C=N3)C2)=CS1 CCC1=CSC=C1C(=O)NC[C@H1]2CCCN(C(=O)CC3=CC=C(C)C=C3Cl)CC2 C[C@@H1](CNC(=O)C1=CN=CC(Cl)=C1Cl)NC(=O)C2(CS(N)(=O)=O)COC2 CCC(=O)CCC(=O)NCCN(CC)C(=O)C1=CN=C2N1CCC2 C=C[C@@H1](C)CCNC(=O)C1=CC(F)=C(O)C(Br)=C1 C#CC1=CC=C(NC(=O)[C@@H1](CC#CC)NC(=O)C=2N=CN(C)N=2)C(C)=C1 COCC(=O)N[C@H1]1CCN(C(=O)C2=CC=C(N3C=CC=C3)N=C2)C[C@@H1]1F O=C(NCCC1CC(NC(=O)C2CC3(C2)OCCO3)C1)C4=C[NH1]N=C4C5CCC5 COCC1(CNC(=O)C2(O)CC2)CN(C(=O)[C@H1]3CCCN3CC4=CC=CC=C4)C1 CC=1C=C(C(=O)N2CC[C@@H1](C)[C@H1](NC(=O)C3(CC)CCC3)C2)N(C(C)(C)C)N=1 CCN1C=CC(C(=O)N2CC[C@@H1](C(=O)NCCC=3C(C)=NOC=3C)C[C@@H1]2C)=N1 C[C@H1]1[C@H1](C)CCC[C@H1]1NC(=O)CCOC2CN(C(=O)CN3CCSCC3)C2 C[C@](CO)(CNC(=O)CC1=N[NH1]C(=N)S1)NC(=O)C[C@H1]2COC(=O)C2 COC=1C=C(C(=O)NCC2=CC(C(=O)NC[C@@H1]3CCC[C@H1]3O)=NO2)N(C)N=1 CO[C@@H1](C(=O)N[C@@](C)(CO)CNC(=O)COC=1C=NN(C)C=1)C2CCOCC2 O=C(NC[C@H1]1CC[C@@H1](C(=O)N2CCC[C@@H1](CO)C2)C1)C3=CSC=C3C4CC4 NC1=NC=CN2N=CC(C(=O)N3CC[C@@H1](CNC(=O)CCCS(N)(=O)=O)C3)=C12 C[C@H1](NC(=O)[C@@H1]1C2C[C@@H1]3C1[C@@H1]3C2)[C@@H1]4CCN(C(=O)C(F)(F)C5CC5)C4 O=C(NCC1=CC=C(F)C(Cl)=C1)C(=O)NOCC(F)(F)F COC(=O)C1=CN=C(Cl)C(NC(=O)C[C@H1]2COCCN2CC=3SC(Br)=NC=3Br)=C1 CCOC(=O)CC1=CC=CC=C1NC(=O)N[C@H1]2CN(C(=O)[C@H1]3CC(=O)N3)C[C@H1]2C CCN(CC1=CC=C2C(=C1)OCO2)C(=O)N[C@@H1](C)C3=C(C)C=C(C)C=C3O COC[C@]1(C(=O)N[C@H1](C)CN(C)[C@H1](C)C2=NN=C3N2CCCCC3)CCCCO1 O=C(/C=C/C1=CC=C([N+1](=O)[O-1])O1)N2C[C@H1](O)C[C@H1]2C(=O)N3CC[C@@]4(C3)CC4(F)F C[C@H1]1[C@@H1](NC(=O)C2=CC=[N+1]([O-1])C=C2)CCCN1C(=O)C3=CN=C(N)C(N)=C3 CSCC1=CN(CC(F)(F)CCC(=O)N[C@@H1](CC(F)(F)F)C(C)(C)C)N=N1 COC1=CC=C(C(=O)N2CCC3(CC2)C[C@@H1]3NC(=O)[C@H1]4CNC(=O)C4)C=C1Cl CC1=CSC=C1C(=O)NC[C@]23CCC[C@H1]2CN(C(=O)[C@H1]CC4=CC=CC=C4)C3 O=C(N[C@]1(CF)CCN(C(=O)[C@@H1]2C[C@H1]3CC[C@@H1]2O3)C1)C4=NOC5=C4CCCC5 N#CC1=CC=C(S(=O)(=O)N[C@H1]2CCC[C@@H1]2C3=CC=C(Br)C(F)=C3)C=C1 CC1=CC(C(=O)N[C@@H1](C(=O)NC[C@@]2(O)CC[C@H1](C)C2)C3=CC=CN=C3)=C[NH1]C1=N CCN(C[C@H1](C)NC(=O)[C@H1]1CCCS1(=O)=O)C(=O)CNS(=O)(=O)C2=CC=CC=C2 C#CCOC1CCN(C(=O)[C@@H1]2CCN(C(=O)C[C@@](C)(O)CCC)C23CCC3)CC1 CN=C1C=CC(C(=O)N2CC[C@H1](CO)[C@@H1](NC(=O)C[C@@H1](C)CN(C)C)C2)=C[NH1]1 CCCN(CCNC(=O)C1=NC=NC=2C(C)=CSC1=2)C(=O)C3=C(C)C=NC=C3C O=C(NC[C@H1]1C=CCN1C(=O)C2=CC=C(F)C(Cl)=C2)[C@@H1]3CS(=O)(=O)CCO3 CCCCN(CCCO)C(=O)[C@H1](CC(C)(C)C)NC(=O)COC1(C)CCC1 CC[C@](C)(CNC(=O)C[C@@H1]1C[C@@H1](C)N(C(=O)CSC(C)(C)C)C1)[C@@H1](C)O CC(=CC(=O)N[C@@H1]1C[C@H1]2[C@@H1]1CCN2C(=O)[C@H1](O)CC3CC3)C4=CC=C(F)C=C4 COC1(CC(=O)N[C@H1]2CC[C@H1](O)[C@H1](O)C2)CN(C(=O)C(C)(C)COC(C)C)C1 CCCC(=O)NC[C@@](C)(O)CNC(=O)CC1=C[NH1]C2=CC=C(C)C=C12 CC1CN([C@H1](C)C(=O)N[C@H1](C)CNC(=O)C2=CN=C(CC(C)C)S2)C1 CC=1C=C(C(=O)NC[C@@]23CCC[C@H1]2CCN3C(=O)C45CC(C(C)(C)C)(C4)C5)ON=1 C=CCC1(NC(=O)[C@@H1]2CC3(CCCC3)CO2)CCN(C(=O)C=4OC=CC=4Cl)CC1 C[C@H1](NC(=O)C1=CC=CC(O)=C1Cl)C2=NC(C(=O)N(C)CC3CC3)=CO2 COCCC(C)(C)C(=O)NCC1(NC(=O)[C@H1]2[C@@H1](C(=O)OC)C2(C)C)CCOCC1 CCCC1=NOC(CCC(=O)O[C@@H1]2C[C@H1]3C[C@H1]2C[C@@H1]3C(=O)OC)=N1 CC[C@H1](NC(=O)C(=O)N(CC1=CC=CC=C1Cl)CC(C)C)C(C)C CC(C)C1=NOC=C1C(=O)N2CCC[C@@]3(CCN(C(=O)CNS(N)(=O)=O)C3)C2 CN(C)CC[C@@](C)(O)C(=O)N[C@@H1]1C2C[C@H1]3[C@@H1](C2)C31C(=O)NCCCCC(C)(C)C C[C@H1]1CCC=2C(C(=O)NC[C@H1]3C=CCN3C(=O)C4=CN=C(O)O4)=CSC=2C1 C[C@@H1]1CCN(C(=O)CSCC(F)(F)F)[C@H1]1CNC(=O)CC2C=NN(C(C)(C)C)N2 O=C(N[C@H1]1C[C@H1]1C(=O)NCCN2CCOCC2)C3=CC=CC(CO)=C3 O=C(CCN(CCO)C(=O)C1=COC(C(F)F)=C1)N=C2C=CN(C3CCC3)[NH1]2 C[C@H1](CNC(=O)C1=CC=NC(Cl)=C1Cl)N(C)C(=O)C2=CC=CC([C@H1]3CCOC3)=C2 C=CCSC1=CC=CC=C1C(=O)N(C)CC[C@@H1](C)NC(=O)C2CC(F)C2 CCNC(=O)C1(CNC(=O)C=2N=C(Cl)SC=2Cl)CC1 CN1N=C(C(=O)N2CC(NC(=O)[C@@H1](O)CC3CC3)C2)C(C(F)(F)F)=C1Cl CN(C)C(=O)C(C)(C)C(=O)N1CCN(C(=O)C2=NC(C3CC3)=CS2)[C@H1](C(F)F)C1 CC(C)OCCCCNC(=O)CCC(C)(C)NC(=O)[C@@H1](C)C=1C=C[NH1]N=1 CCC=1C=NSC=1C(=O)NC[C@H1]2[C@@H1](C(=O)N3C[C@H1](CO)[C@@H1](CO)C3)C2(C)C CN(CCCCN(C)C(=O)[C@H1]1CC1(C)C)C(=O)C[C@H1]2CCCCC2(F)F COC1=CSC=C1C(=O)N2CC[C@@]2(C)CC(=O)N[C@H1]3CCC[C@@H1]3F CCC[C@](C)(CC)C(=O)NC[C@@H1]1C[C@@H1](C)N(C2=NC(Cl)=NC3=C2COCC3)C1 C/C=C/CCOC(=O)[C@H1](C(=O)OCC)C1CCCC1 CC1=CC(C(=O)N(C)C2CCN(C(=O)C3=CN4C=CN=C4C=N3)CC2)=NN=C1C COC(=O)NCC(=O)N1CCCC[C@@H1](NC(=O)CCS(=O)(=O)N(C)C)C1 COC(=O)C1=CN(CCNC(=O)N(CCCS(C)(=O)=O)CC2CC2)N=N1 CN(C)C[C@@H1]1CCC[C@H1]1NC(=O)[C@@H1]2C=C[C@H1](NC(=O)C=CC3CC3)C2 C#CC[C@@H1](O)C(=O)NC[C@@]1(F)CC[C@H1](NC(=O)C2=CC=C(OCCO)C=C2)C1 CCN1C=CC(C(=O)N2CCC[C@]2(C)C(=O)NCC3=CC=CC=C3C#N)=C1C CCN1C(C(=O)N[C@@H1](C)[C@H1]2CCN(C(=O)CC3=CC(C)=CS3)C2)=CN=C1O O=C(NCCCN1C=CN=C1O)NC[C@@H1]2CC3(CCCCC3)CO2 COC1=NC=C(Br)C(=NC[C@@H1]2CCCC[C@H1]2NC(=O)CN3N=CN(C)C3=O)[NH1]1 CC1=CC=NC(C(=O)N[C@@H1]2CCC[C@H1]2NC(=O)C3=CC4=CC(Cl)=C(Cl)C=C4[NH1]3)=C1 CC1=CC(CC(=O)N2CC(N(C)C(=O)C3CC(CCF)C3)C2)=CC=C1Cl CC1(C)CN(C(=O)C2=NC=CC=C2F)CC[C@@H1]1NC(=O)C3=CC=CC=4C=CSC3=4 CC1=CON=C1C(=O)N2C[C@@H1]3C[C@H1]2[C@@H1]3NC(=O)C=CC=4C=NN(C)C=4C O=C(NCCN1C=CN=C1)[C@@H1]2CC(F)(F)CN2C(=O)[C@]3(F)CCOC3 C[C@@H1]1C[C@@H1]1NC(=NC[C@@H1]2CCN(C3=CC=C(Cl)C=C3)C2)N4CC=C(F)C4 CC1=CC=C2N=CC=CC2=C1C(=O)N[C@H1](C)CCNC(=O)COCCF O=C(CCOCC(F)(F)C(F)F)NC[C@H1]1CCN1C(=O)[C@@H1]2CC(=O)N(O)C2 CC(C)(C)C[C@H1]1CCCN1C(=O)C(=O)N2CC[C@H1](CC3=CC=NC=C3)C2 C[C@@H1]1C[C@H1](NC(=O)C2(N=[N+1]=[N-1])CC2)CN(C(=O)C3=CC=C4N=C(O)[NH1]C4=C3)C1 CC1=CC=C(C=2N=C([C@H1]3CC4=CC=CC=C4O3)N([C@@H1](C)C5CC5)N=2)C=C1Br CN1C=CC=C1CCC(=O)NC[C@H1]2CCCN(C(=O)[C@H1]3CCCC34CC4)C2 C=CCC1(C(=O)NCCCCNC(=O)[C@H1]2CC(=O)N(CC)C2)CCCC1 O=C(NCCN(C(=O)CCCNC(=O)[C@H1]1CCCO1)C2CC2)[C@@H1]3C[C@@H1]3C(F)F CCC1(C(=O)N(C)CCN(C)C2CC2)CN(C(=O)[C@H1]3CCCC(=O)C3)C1 ClC1=CC(CN2CC(F)(F)C[C@@H1]2C3=NC=C4C(=N3)CCC4)=C(Cl)C=N1 CCC1=NC2=CC(NC(=O)CNC=3C=N[NH1]C=3)=CC=C2N1C4=CC=CC=C4 COC[C@@H1](C)[C@H1](C)C(=O)N1CC(OCCNC(=O)C2(S(C)(=O)=O)CCC2)C1 C=CC1(C(=O)N2CCCN(C(=O)C=3OC=NC=3CC)CC(C)(C)C2)CCCC1 CC(C(=O)N(C)CCNC(=O)C1=CN(C(F)F)C=N1)=C2CCC2 CCCC=C[C@@H1](O)C(=O)N[C@@H1]1CCC[C@@H1]1NC(=O)C2=CC=C(O)C(N)=N2 CCOC1=CC=C(CNC2=CC3=CC=C(C4=CC(SC)=CN=C4F)C=C23)C(O)=C1 O=C(C1=CN=C2N1CCOC2)N3C[C@H1]4CCN(C(=O)C[S@](=O)C(F)(F)F)[C@H1]4C3 CNC1=CN=CC(C(=O)N(C)CCCC(=O)N2CC(N(C)C3CC3)C2)=C1 CC1=NOC2=NC(C(=O)NC[C@@H1]3CN(C(=O)COCC(F)F)C[C@H1]3C)=CC=C12 N#CCC(=O)N1CCCC[C@H1]1CC(=O)N[C@H1]2CCOC2 CN(C(=O)C1=CC(O)=CC(O)=C1)C2CN(C(=O)C3=CC=NC4=CC=C(O)C=C34)C2 C[C@@H1]C1[C@@H1](C)CN(C2CCN(C(=O)C(=O)NCCC3=C[NH1]C4=CC=CC=C34)CC2)C1 C[C@H1](C(=O)N1C[C@H1](O)C[C@@H1]1CNC(=O)C2=NC=NC3=C2C=NN3C)C=4C=C[NH1]N=4 CN1C=CC(CCC(=O)N2CCC(NC(=O)C[C@H1]3C[C@H1]4C=C[C@H1]3C4)CC2)=N1 CC(C)CCC[C@H1](C)C(=O)NC[C@H1](C)N1C=C([C@H1]2CCN(C)C2)N=N1 CC=1N=NSC=1C(=O)N[C@@H1]2C=CCN(C(=O)[C@@H1](C)N3CCC(O)CC3)C2 CS[C@H1](C)CCC(=O)N1CCC[C@](CO)(NC(=O)C=2C=CN3N=NN=C3C=2)C1 CCCC=CC(=O)N[C@H1]1CC[C@@H1](O)CN(C(=O)[C@H1]2CCC3=NN=C(C)N3C2)C1 CC=1[NH1]N=C(C(=O)NCC[C@@]23CC[C@@H1](C2)N(C(=O)C[C@H1](C)C(F)F)C3)C=1Cl CC[C@H1](NC(=O)[C@@H1](F)[C@H1]1CCN(C(=O)C=2SC=CC=2F)C1)C3=NC=NN3C CN(C)CCC1(C(=O)NCCOCCOCCCNC(=O)/C(F)=C/CCF)CC1 CC[C@@]1(C)C[C@H1]1C(=O)N2CC(NC(=O)C=3[NH1]C=C(C)C=3C)(C4=CC=CC=C4)C2 COC1=CC=C(C=NOCC(=O)N[C@H1](C)CCNC(=O)[C@@H1]2CC2(C)C)C=C1 C=CC(F)(F)C(=O)N1C[C@H1]2CC[C@@]2(CNC(=O)CCSC)C1 C=CCCC1=CC=C(C(=O)N[C@H1]2CCCN(C(=O)C3=CC(C)=NO3)CC2)C=C1 COC1=CC=CC(C(=O)N[C@H1]2CCN(CC(=O)NC3=CC=CC(Br)=C3)C[C@H1]2)=C1O CC[C@H1](C(=O)N1C[C@H1](NC(=O)CC2=NOC3=CC=CC=C23)C4(CC4)C1)C(C)(F)F CC1=NC(C(=O)N2CC[C@H1]([C@H1](F)C(=O)NCC3=CC=CN=C3Cl)C2)=CS1 CSC1=CC(C(=O)NC23[C@H1]COC[C@H1]2CN(C(=O)C4CN(C(C)=O)C4)C3)=C(C)O1 CC=1OC(C(=O)N[C@H1]2CC[C@](C)(CNC(=O)C34C5C6C7C5C3C7C64)C2)=CC=1CO COCC(=O)N[C@H1](C)C(=O)NC[C@]1(F)C[C@H1](CNC(=O)C2=C[NH1]C(C(N)=O)=C2)C1 CC(C)(CCNC(=O)C1=CC(N2CCSCC2)=CC=C1N)NC(=O)CNC(N)=O CN1C=C2C(=N1)C[C@H1](C(=O)NC[C@@H1](O)CNC(=O)C(C)(C)[C@@]3(O)CCOC3)CC2 C=C(I)CC(=O)N[C@H1]1CC[C@H1]1NC(=O)C2=CC(O)=CC=C2F COC[C@@]1(C)CCN(C2=NC(=NCCS(=O)(=O)N3CCCC3)[NH1]C4=C2CSC4)C1 C[C@H1]1CN(C(=O)C2=CN=NC(Cl)=C2)C[C@H1]1NC(=O)[C@@H1](C)N3C=C(Cl)C=N3 COC1(C[C@H1](NC(=O)C(=O)N2CCC3(CC3)C2)C(=O)O)CCCCCC1 CCN(CC1=CC=CC=N1)C(=O)[C@H1]2C[C@@H1](NC(=O)CC3=CC=CN=C3Cl)C2 CCOC[C@H1](NC(=O)C1=CC=C(F)S1)C(=O)N2CCC[C@](C)(CO)C2 CSC[C@H1](C)C(=O)NC[C@@H1]1CCC2(CN(C(=O)CN3C=CC(C)=C3)C2)O1 COC[C@@]1(C(=O)N2CC(OCCNC(=O)CCCCCNC(N)=O)C2)C=CCC1 COCO[C@@H1](C)C(=O)NC[C@H1](C(=O)NCCOCC1CC1)C(C)(C)C CSCCC(C)(C)C(=O)N[C@@H1]1CC=C(C(=O)N2CCC([C@@H1](C)O)CC2)C1 C#CCC(C)(C)C(=O)N1CC(C[C@H1](F)C(=O)NC2=CC=CC=C2OC)C1 COC1=CC=C(N2N=NN=C2[C@H1](NCCCCS(N)(=O)=O)C3=CN=C[NH1]3)C(C)=C1 C[C@@H1]1CN(C(=O)CC2=CC(Cl)=CC(C(F)(F)F)=C2)C3=CN=CC=C3O1 COC1=CC(F)=C(COC(=O)C=2C=CC3=NC=C(I)N3C=2)C(F)=C1 CO[C@]1(C(=O)NC[C@H1]2CC3(CO2)CN(C(=O)[C@H1](C)C#N)C3)CCSC1 COC1(C)CN(CC(=O)N2CC(C)(NC(=O)[C@@H1]3C[C@@H1]4C=C[C@H1]3C4)C2)C1 CCC[C@@](C)(O)CC(=O)NC[C@@H1]1CCN1C(=O)CCOC2=C(F)C=CC=C2Cl O=C(NCCC1=CC=CC(Cl)=C1Cl)[C@@H1]2[C@H1](O)CCN2CC=3SC=C4C=3OCCO4 O=C(NCC[C@@H1]1CSCCN1C(=O)CS(=O)(=O)C[C@H1]2CCCO2)C3=CC(F)=C[NH1]3 N#CC1=CC=NC(N[C@@H1]2CN[C@H1]3CCCC[C@H1]3C2=O)=C1 CC=1OC(C(=O)N[C@@H1](CO)CNC(=O)C2=CN=NN2C3=CC=CC=C3)=CC=1CO NC(=O)N1CC(N2CC[C@@H1]2CC(F)(F)F)(C3=NN=NN3C[C@H1]4CCCO4)C1 CCOC1=CC=CC=C1C(=O)N(C)CC2CN(C(=O)[C@H1](C)NC(=O)CC)C2 CC1=CC(C(=O)N[C@H1]2CCCC[C@H1]2CC(=O)NC[C@@H1]3CC3(C)C)=CN=C1O CC=1[NH1]N=C(C(=O)NC[C@H1]2[C@H1](N=C3[NH1]N=C(O)S3)CS(=O)(=O)[C@H1]2CC)C=1C CCC=1N=C2C=CC=CN2C=1C(=O)N3CC(O)(CN(C)C(=O)C4CS(=O)(=O)C4)C3 C#CCCCC(=O)N[C@@]1(CC)CCCN(C(=O)CC2=CC=C(C)N=C2)C1 CC1=CC(C(=O)N[C@@H1]2C[C@@H1](C)N(C(=O)[C@]34CC[C@H1](CC3)C4(C)C)C2)=NN1CCO CC=1C=C(Br)OC=1C(=O)N2C[C@@H1](NC(=O)C3=NSN=C3O)C[C@H1]2C CC[C@H1]1CCN(C(=O)C2CC(C)C2)[C@@H1]1C(=O)NCC3CCC(CC)CC3 CC1=C(C(=O)N[C@H1]2CN(C(=O)C3CCSCC3)CC4(CCC4)C2)CCC(C)(C)C1 CC(=O)C1=CC=C(C(=O)NC[C@H1]2C=C[C@@H1](NC(=O)C3=CCC[C@@H1]3C)C2)O1 CC1=CC=C2C(C=CN2CCC(=O)N[C@@H1]3CCC34CN(C(=O)[C@H1]5CC5(F)F)C4)=C1 O=C(N[C@@H1]1CCCN(C(=O)C2(O)CCC2)CC1)[C@@H1]3CCNC3 O=S(=O)(C[C@@H1]1C[C@H1]2[C@@H1](C1)C2(F)F)NC3(C4=CC=C5C(=C4)OCO5)COC3 CNC(=O)C1=CC=C(CN2CCC[C@@H1](NC(=O)C3=CN=NN3C)C2)C=C1 C#CC1=CC=CC(C(=O)N2CC[C@](C)(CNC(=O)[C@@]3(OC)CCOC3)C2)=C1 CN1C=NC2=C1C[C@H1](CNC(=O)N3C[C@H1]4C[C@@H1]3C[C@@H1]4OC)CC2 CO[C@H1](C(=O)N[C@@H1]1CCCC[C@H1]1CNC(=O)C2=NC=CC=C2Cl)[C@@H1]3CCOC3 O=C(NCC(F)F)[C@@H1](C1=N[NH1]C2=CC=CC=C12)N3CC[C@@H1](SC4=CC=CC(Cl)=C4)C3 CC(=O)N(C)[C@@H1](C)C(=O)NCCOCCC(=O)NC1=CC(C)=C(C)C(Br)=C1 CCN1N=NC=C1C(=O)NC[C@H1](O)CC(=O)N[C@@H1](C)C2=NC=CN2C C=CCC1(C(=O)N2CCC[C@](CO)(NC(=O)[C@@H1](C)N3CCC[C@@H1](O)C3)C2)CCC1 CC(C)C[C@@H1](CNC(=O)C1=NC=C(Cl)S1)NC(=O)CNS(C)(=O)=O C=C(Br)CCC(=O)N1C[C@@H1](F)C[C@H1](NC(=O)[C@@]23CCC[C@@H1](C2)OC3)C1 COC1=NSC=C1C(=O)N2CC[C@@H1]3C[C@]32C(=O)N4C[C@@H1]5CC[C@@]5(C)C4 CCNC1=CC=CN=C1C(=O)NC[C@H1]2CN(C(=O)CS(=O)(=O)CCO)CC2(C)C C=CCOCCNC(=NCCC1=NN=C(C)S1)NC[C@H1]2C(=O)NCC[C@H1]2C CC1=NN2C(=C1C(=O)NC[C@@H1]3CCC[C@H1]3NC(=O)C4=NO[C@@H1](C)[C@@H1]4C)CCCC2 O=C(NCCCO)C1=CC(C2=NC(C=3C=C[NH1]N=3)=NN2[C@H1]4CCSC4)=CC=C1F CC1=CN(C)N=C1C(=O)N2CC[C@@H1](NC(=O)C3CCC(S(N)(=O)=O)CC3)C2 CCCC[C@H1](CC)CCC(=O)N1C[C@H1](NC(=O)CC2CSC2)[C@H1]3CCC[C@H1]31 CC(C)C[C@H1](NC(N)=O)C(=O)N[C@H1](C)C[C@@H1](C)NC(=O)CN1C=CC=C(N)C1=O C=C(Cl)C[C@H1](N)C(=O)N[C@H1]1C[C@@H1]2CC[C@H1]1C[C@@H1]2O CCC[C@H1](C)[C@@H1](CO)NC(=O)NCC1=NC=C2C(=N1)C=CN2C3CC3 CC(C)CCCCN(C)C1=NN=C(CC2=C(F)C=C(Br)C=C2Cl)N1CCC#N CCCCSCCC(=O)NC1([C@@H1]2CCCN2C(=O)CCOCCC)CC1 CC(=O)N(C)CCCC(=O)N1CCO[C@]2(CCN(C(=O)C3(C4CCC4)CC3)C2)C1 CC1CCC(CN(C)C(=O)C2=CCN(C(=O)[C@H1](O)C3CC3)CC2)CC1 COCC[C@H1](CNC(=O)[C@H1](C)C1=CN=CN=C1)NC(=O)C2=NN(C)C(=O)C=C2C CC(=O)NC1=CC=C(C(=O)N2C[C@@H1]3C[C@]3(CNC(=O)C4CC(C5CC5)C4)C2)C=C1 C=C[C@H1](O)C(=O)N[C@H1](C)[C@@H1]1CCCN1C(=O)CN(C)C(=O)C2=CC=CS2 CN(C)C(=O)C=CC(=O)N1CCC[C@@]1(C)C(=O)N2C[C@H1]3CC[C@@]3(C)C2 COC1=CC=C(C(OC)C(=O)N[C@@]2(C)CCS(=O)(=O)C2)C=C1 O=C(CC1CCCCC1)N2CC[C@H1]3CCN(C(=O)[C@@H1]4CCN5N=CN=C5C4)[C@H1]3C2 O=C(NC12CCC(NC(=O)[C@H1]3C[C@]34CCC5=CC=CC=C54)(CC1)C2)/C(Cl)=C/Cl CC1=NC(CC(=O)N2CC(C)(C)C(NC(=O)C3=CC=CO3)C(C)(C)C2)=CO1 CCC[C@@H1]1CCCN1S(=O)(=O)C2=CC=C(NCC(C)(C)OC(C)C)N=C2 CCCCCCCCN(C)C1=CC=C(Br)C(S(=O)(=O)NC2(CC(N)=O)CC2)=N1 CC(C)[C@H1](C)CC(=O)N1CCC[C@@](F)(CNC(=O)[C@@H1]2CCC3=NN=CN3C2)C1 C#CCOCCCCOCC(=O)N1CCN(C(=O)C2=CSC(C(N)=O)=N2)[C@H1]3C[C@H1]31 CC(C)[C@H1](C)C(=O)NC1=CC=CC(NC(=O)[C@H1]2C[C@@H1](C(F)(F)F)C2)=C1 COCC[C@H1](OC)C(=O)NC[C@H1]1CN(C(=O)C2=CC=C(C(F)F)N=C2)CC13CC3 O=C(NC[C@@H1]1C[C@H1]2CC[C@@H1]1O2)[C@H1]3CCN(C(=O)C=CC4=CC=NC=N4)C3 COC1=CC=NC(C(=O)N2CCOC[C@@H1]2CCNC(=O)[C@@H1]3NC(=O)O[C@@H1]3C)=C1C C[C@H1](O)CCONC(=O)[C@H1]1CC[C@H1](CNC(=O)[C@H1](C)[C@H1](O)C(C)C)CC1 CC1=NSC=C1C(=O)N2[C@@H1]3CC[C@@H1](C3)[C@H1]2CC(=O)NC[C@H1]4C[C@]45CC5(F)F CC1=NSC=C1CC(=O)NC[C@@H1]2CCCCN2C(=O)[C@@H1]3COC[C@H1]3C(F)(F)F CN1C[C@H1](CN2CCNC[C@@H1](O)C2)CC1=O C[C@@H1](CN(C)C(=O)C1=CN2C=CC(F)=CC2=N1)NC(=O)CCCCC#N CO[C@@H1](C(=O)NCCN(C(=O)C(C)=CN1C=CN=N1)C(C)C)C2=CC=CN=C2 C[C@@](CNC(=O)C1=CC=C(O)C(Br)=C1)(C2=CC=CC=C2)C(F)(F)F CCCN1CCC[C@H1]1CNC(=NCCCF)NCC2=CC=C(Cl)C=C2C(C)C C[C@H1]1C[C@H1](CNC(=O)C=2C(Cl)=NN(C)C=2Cl)CN1C(=O)C3=CN=C(S)N3C4CC4 CC(C)N1N=CC(C(=O)NCCOC(C)(C)CNC(=O)[C@H1]2CCCC[C@@H1]2F)=C1F C[C@H1](C(=O)NC1CC(C)(C(=O)N2CCO[C@H1]3CCC[C@H1]32)C1)N4C=CN=N4 O=C1CC[C@H1](CCC(=O)N2CC3=C(C2)CN(C(=O)[C@@H1]4COCCN4C=O)C3)CN1 CCC1=NC(C(=O)N2C[C@H1]3CC[C@@H1](C2)C3CC(=O)NC4=CON=C4C)=CO1 O=C(N[C@@H1]1C[C@H1]2CC[C@H1]1N(C(=O)[C@H1]3C[C@@H1]3F)C2)C4=CC=C([N+1](=O)[O-1])C=C4 CO[C@]1(C(=O)N2CCCC[C@H1](NC(=O)[C@H1]3CCC[C@H1]4CCCN43)CC2)CCSC1 C[C@@H1](CCCCNC(=O)[C@H1]1CC(=O)CO1)NC(=O)C2=C(Cl)C=NN2C C[C@H1](CC1CCN(C(=O)C2=CC=3OC=CC=3S2)CC1)NC(=O)C4=CCCSC4 CC1=NC(NCCCC2=NN=CN2C)=CC(NCCNC(=O)CC3=CC=CC=C3)=N1 C#CCC[C@H1](O)C(=O)N1CCN(C(=O)CN2CCC3=CC=CC=C32)[C@H1]4CC[C@H1]41 COC1=CC([C@H1](C)NS(=O)(=O)C=2SN=NC=2C3CC3)=CC=C1OCC(C)C O=S(=O)(N[C@@H1]1CCN2N=CN=C2C1)C3=CC4=CC=CC=C4C=C3Br C=CC[C@@H1](C)C(=O)NC[C@@]1(O)CCN(C(=O)CC=2C(C)=NN(C(C)(C)C)C=2C)C1 CC1=CN=C(C=CC(=O)NC[C@@H1]2C[C@H1]3CC[C@H1]2N(C(=O)C4OCCO4)C3)[NH1]1 O=C(N[C@H1]1C[C@H1]2C[C@H1]1CN(C(=O)/C=C/C3=CC=CC(Cl)=C3Cl)C2)C4=CCCCC4 C=C[C@H1](CCC)CC(=O)N(C)CCC1CCN(C(=O)COC)C1 COC(=O)[C@@H1](OC)C(=O)NC1(CCNC(=O)C=2C=CN3N=CC=CC=23)CCCC1 CN(CC(=O)NC(C)(C)CCNC(=O)C1=CN=C2C=C[NH1]C2=C1)CC(C)(C)C C=C(Br)CC(=O)N1CCOC[C@H1](NC(=O)C=2C=CC(=O)N(CCOC)N=2)C1 CCN1C=CN=C1[C@@H1]2[C@H1](C(=O)N3CCOC4=CC=C(O)C=C4C3)CC(=O)N2CC CC1=NC=CC(C(=O)N(C)[C@@H1]2CC[C@H1](NC(=O)C3=CN=C4SC=CN34)C2)=N1 COC1(C2(NC(=O)[C@@H1]3CC(=O)N[C@H1](C=4C=NN(C)C=4)C3)CCC2)CCC1 CN1C=C([C@@H1]2CN(C(=O)C3=CN=CC(F)=C3)C[C@H1]2NC(=O)C=CCO)C=N1 CCOC1=CC=CC=C1C(=O)N2CCN(C(=O)C3=CC=C(Cl)N=N3)C[C@@H1]2C CCCOCCCC(=O)N1CC[C@@](CF)(NC(=O)[C@@H1](C)CC2CCCC2)C1 CN(CC(=O)N[C@]1(C2CC2)CCN(C(=O)C3=CCOCC3)C1)C4=CC=C(Cl)C=N4 CN1N=NC2=C(C(=O)N[C@@H1]3CCC[C@@H1]3NC(=O)C=4C=CSC=4C(F)F)C=CC=C21 CC[C@@H1](NC(C)=O)C(=O)NCC1=NOC=C1C(=O)NC2(C)CC2 CC1=C([C@H1](C(=O)NCC2=CC=CS2)N3CC=CC3)C=NC=C1C(F)(F)F CCN1N=NC=C1C(=O)NCC2(CO)CCN(C(=O)CCC3=CC=NC=C3)CC2 CCOC(=O)C(C)(C)NC(=O)C[C@@H1]1CN(C(=O)C2=CC(O)=CC=C2C)C[C@H1]1C CCN1C[C@@H1](C(=O)N2CC=C[C@H1]2CNC(=O)C=3C(C)=NOC=3C4CC4)CC1=O C=CN1N=NC=C1C(=O)NCCN(C)C(=O)[C@H1]2CN3CCC2CC3 CNC(=O)[C@]1(C)CCN1C(=O)CC2=CCN(C(=O)[C@H1]3CCCN3C(C)=O)CC2 CC=1[NH1]N=C(C(=O)NC[C@H1](NC(=O)[C@@H1]2C[C@H1]2C#N)[C@@H1](C)C(C)C)C=1Cl C#CCCN(C)CC(=O)N[C@@H1]1C[C@H1]1NC(=O)C2=CC=C(Br)C(C(=O)OC)=C2 C#C[C@]1(O)CCCN(C(=O)[C@@H1]2COCCN2C(=O)[C@H1]3C[C@]3(C)C(C)C)C1 CC1=NOC(SCC(=O)NCCOCCCNC(=O)[C@H1]2CCC(=O)N2)=N1 C#C[C@@H1]1CN(C(=O)[C@@H1](F)CC2CN(C(=O)CC=3C=CN(C)N=3)C2)C[C@H1]1O CC[C@@H1](CNC(=O)C1=CCSC1)NC(=O)C2=CC3=CC=CC(C)=C3N=N2 CCC(CC)[C@@H1](OC)C(=O)N[C@@H1]1CC12CC(NC(=O)C3=C(C)C=CC=C3OC)C2 CC1=CC=C(NCCC(=O)N(C(=O)CCCC=2N=N[NH1]N=2)C3=CCCC3)C=C1Cl COC1=CC=C(O)C=C1C(=O)N(C)C2CCN(C(=O)[C@H1]3CCC[C@H1](OC)C3)CC2 CC(C)(C)C(C)(C)C(=O)N1C[C@@H1](NC(=O)C2=COC(CO)=C2)C3(CC3)C1 C[C@H1](NC(=O)C1=NC=NC=C1Cl)[C@@]2(O)CCN(C(=O)CN(C)C)C2 CCN1C[C@H1](C(=O)N2CC[C@H1](C(C)(C)NC(=O)CNC(N)=O)C2)NC1=O C[C@@H1](NC(=O)C12CC(N)(C1)C2)C3=NN=C4C(=O)[NH1]C=CN34 C=C(C)CC(=O)NC[C@@H1](F)C1CCN(C(=O)CC=2C=CSN=2)CC1 CC[C@H1]1C[C@@H1]1C(=O)N2CC(C[C@@H1](C)NC(=O)CCC(C)(C)CN(C)C)C2 COC(=O)C1=CC(C)=C(N(C)CCN(C)C(=O)OC2CCCC2)C([N+1](=O)[O-1])=C1 CCC1=NC=C(C(=O)N2C[C@H1]3[C@H1](CNC(=O)[C@@H1](C)CCCOC)[C@H1]3C2)S1 C[C@H1](CC1CN(C(=O)[C@H1]2CCC(=O)N2C)C1)NC(=O)C=3N=CN4C=C(Cl)C=CC=34 COC[C@H1](C)C(=O)N1CC[C@@H1](C(=O)NCC2=C(F)C=CC=C2F)[C@H1]1C(C)C COC[C@H1](NC(=O)C[C@@H1]1CC1(C)C)C(=O)N[C@@H1]2CCC3=CC=CN=C32 CC(C)(C)OC(=O)N1CCC2(COC[C@@H1](CN=C3[NH1]C=C(C4CC4)C=N3)O2)CC1 CC(C)[C@@H1](CCO)NC(=O)CCCOC1=CC=C(F)C=C1F CC1=C(C)C[C@@H1](C(=O)NCC2(N(C)C(=O)CC34COCC(C3)C4)CC2)CC1 CC1=CC=NC(C(=O)NC2(CNC(=O)C=3N=NSC=3C)CCCCC2)=N1 COCC[C@H1](C)CN1N=NN=C1N2CCC([C@@H1]3CCCO3)CC2 C=CCO[C@H1](C)C(=O)N1CCC=2SC=CC=2[C@@H1]1CNC(=O)C=3C=COC=3CCC C#CCOCCC(=O)N(C)[C@H1]1CCN(C(=O)CS(=O)(=O)CC(F)(F)F)C1 CC[C@@H1]1C[C@H1](C(=O)NCCCN(CC2=CC=C(C3=NC=CS3)C=C2)C4CC4)CCO1 C[C@H1]1C[C@@H1]1CCCC(=O)N[C@H1](CCOCCO)C(=O)N(C)[C@@H1]2C[C@@H1]2C O=C(NC[C@H1]1C[C@H1](NC2=NC=NC(Cl)=C2CO)C1)C3=CC=C(Cl)N=C3Cl CC(C)(C)CCC(=O)N1CC(C[C@@H1](F)C(=O)NC2=CC=C(O)C=C2)C1 CCCN1N=CC=C1C(=O)N[C@H1]2CC[C@H1](CNC(=O)C=C[S@](C)=O)C2 C[C@@H1]1CN(C(=O)CCC2(C)CN(C(=O)[C@@H1]3C[C@H1]3C4CCCC4)C2)CC(C)(C)C1 CC(C)C[C@H1](N)C1=NOC(C=2C=NN(C3=CC=C(Br)C=C3)C=2CCO)=N1 COC1=CC=C(CN[C@@]2(C3=NN=NN3C4COC4)CCC[C@H1](C#N)C2)N=C1 CCC1=NO[C@H1](C(=O)N[C@H1](C)[C@@H1]2CCCN2C(=O)C3=CC=C4C(=C3)OCCO4)C1 CC1=CC(F)=C(CN[C@H1](CO)C2(O)CCC2)C=C1F CCCCC1=NC(CNC2=NC(C3=CC=NS3)=CC(C)=C2C)=C(Cl)[NH1]1 O=C([C@@H1](O)C1CCCC1)N2CCN(CCCNC(=O)C3(CF)CCOCC3)CC2 C[C@@H1](NC(=O)CNC1=NC2=CC=C(C3=CC=CC=C3)C=C2C1)C4=CC=CC(F)=C4 CCC[C@@H1](CNC(=O)CCCN(C)C)NC(=O)CNC(=O)CC(C)C CC1=NOC(C)=C1CCC(=O)N2CC3(C2)CN(C(=O)C4=CN=CS4)C[C@@H1]3CO C[C@H1](C(=O)NC[C@H1]1CN(C(=O)[C@@H1]2CCCCNC2=O)CCC1(F)F)C=3C=CSC=3 CN1C(CO)=NC2=CC(C(=O)N[C@H1]3C[C@@H1]3NC(=O)C4(C(F)F)CCC4)=CC=C21 C=CC[C@H1](C)C(=O)N1CC[C@H1](N(CC2CC2)C(=O)[C@@H1]3CCC(=O)N3CC)C1 C[C@@H1](CN1C=C(CNC(=O)C=CC=2C=C[NH1]N=2)N=N1)N3CCCCCC3 COC(=O)C[C@@H1](C)CC(=O)N1CC[C@H1]2[C@@H1](C1)CN2C(=O)C=3C=C(C(F)(F)F)ON=3 C[C@@H1](O)CC1=CN(C2CN(C[C@@H1](O)CC3CCCCCC3)C2)N=N1 C=CC1(CC(=O)N(C)CCN(CC)CC)CN(C(=O)C=CC(=O)N(C)C)C1 CO[C@H1]1C[C@@H1](CC(=O)N(C)CCOCCC(=O)N2CC3(CNC(=O)OC3)C2)C1 CO[C@@H1](CSC)C(=O)NCCCC(=O)N1CC(C2=NC=CS2)C1 COCCCC(=O)N[C@H1]1CC[C@@H1]1NC(=O)C2=CC=C(O)C=C2C CC1=CN=C(N(C(=O)C2=N[NH1]C=C2I)[C@H1]3C[C@@H1]4CC[C@H1](C3)N4)C(C)=N1 C[C@H1](O)C1(NC(=O)C2=N[NH1]C=C2CNC(=O)CCC(N)=O)CC1 CC1=NC=C(C(=O)N(C)C(C)(C)CC(=O)N2C[C@@H1](CO)[C@@H1](O)C2)C=C1C#N C[C@]1(C(=O)N2C[C@H1]3[C@H1](NC(=O)C4=CC(=N)[NH1]C(Cl)=N4)[C@H1]3C2)CCNC1=O CC1=CSC(C=CC(=O)NC[C@H1]2CCCC[C@@H1]2NC(=O)C=3C=NOC=3C)=N1 CC1=C(CC(=O)NC[C@@H1](C)N(C)C(=O)C2=C(S(C)(=O)=O)C=NN2C)C=NN1C CC[C@H1](C)C1=CC=C(C(=O)N(C)CCCN(C)C(=O)[C@H1]2CCC(F)(F)C2)C(O)=N1 CCC=1OC=CC=1C(=O)N2CC(C3(NC(=O)C=C4CCCCC4(C)C)CC3)C2 COC(C)(C)C[C@H1](N[C@H1](C)C1=C(F)C=CC=C1Br)C2=NN=NN2C3CC3 CCCC(=O)NCC(=O)N[C@H1]1C[C@H1](CNC(=O)CCCCCCCC2CC2)C1 CN1C=CN=C1CCC(=O)N2CCC=C(C(=O)N3CCCC[C@@](C)(F)C3)C2 CCSC1=CC=C([C@H1](C)NC(=O)C2=CC(S(N)(=O)=O)=CS2)C=C1 COC1=NC=CC=C1C(=O)N(CCCNC(=O)C2CC(C)C2)C(C)C C=C=C[C@H1](C)C(=O)N[C@H1](C)CN(C)C(=O)C1=CC=NC(=C1OC2CCCC2)OC O=C(NC[C@@H1]1CCN(C(=O)C2=C[C@H1]3C=C[C@H1]2C3)C1)C4=C[C@H1]5CCC[C@@H1]45 O=C([C@H1]1C2CCC(CC2)[C@H1]1C(=O)N3CCOCCO3)N(CCOCCO)C4COC4 C#C[C@]1(C(=O)N2[C@H1]3CC[C@H1]2CC(CC)C3)CCN(C(=O)[C@H1]4C[C@H1]5[C@@H1](C4)C5(F)F)C1 CON(C)C(=O)C[C@H1]1COCCN1C(=O)[C@H1](C)NC(=O)C2CC2 CCCC1=NC(C(=O)NC[C@H1]2C[C@]3(CCN(C(=O)C4CCCCC4)C3)CO2)=CS1 C#CCCN1CCC(C(=O)N2CC[C@](CF)(NC(=O)[C@@H1](O)C(C)(C)C)C2)CC1 CN(C(=O)C1=CC=C(C(F)F)N=C1)[C@@H1]2CC[C@@H1](NC(=O)C(C)(C)C3=CN=CO3)C2 CC1=NC=CN=C1C(=O)N[C@@H1]2C[C@@H1]2CNC(=O)[C@H1](C)CC3CC3 CSC1=CC=CC(C(=O)N2CC[C@@H1](C)N(C(=O)[C@H1]3C[C@@H1]4CC[C@H1](C3)[C@H1]4F)CC2)=C1 C[C@H1]1CCN1C(=O)[C@@H1]2CN(C(=O)[C@H1](C)C3CCCCC3)CC(C)(C)C2 C=C[C@H1](CC)CC(=O)N1CC(CO)(NC(=O)C2=CC=C3SC=C(C)C3=C2)C1 COC1=NC=NC(OC)=C1C(=O)N2CC(NC(=O)C=3C=C([C@@H1]4CCOC4)[NH1]N=3)C2 COC=1C=C(CCC(=O)N[C@@H1]2CCC[C@H1]2NC(=O)C3(COC(C)C)CC3)ON=1 COC1=NC=C(C(=O)N2CC[C@H1](N(C)C(=O)C3=CC=C(C)N=C3O)C2)C=C1F CCCNC(=O)CN1C=CC(=NC(=O)[C@]2(N)COC(C)(C)C2)[NH1]1 COCC(COC)NC(=O)[C@@H1]1CN(C(=O)CN2C[C@H1]3C[C@H1]3C2)CC1(F)F C[C@H1](CCC(=O)NC[C@H1]1CN(C(=O)COCC=2SC=NC=2C)CCN1C)N(C)C CCOC=CC(=O)NCC1=CCN(C(=O)CC2=NOC3=CC(F)=CC=C23)CC1 O=CN[C@H1](N1CCOCC1)C2=NN=C(SCCCCC3=CC=CC=C3)S2 CCCC[C@@H1](NC(=O)[C@@H1]1C[C@H1]2C=C[C@@H1]1O2)C(=O)N[C@@H1](C)C3=NC=CC(O)=N3 CC[C@@H1](C(=O)NCC[C@@H1]1CCN(C(=O)CSC2CC2)CC1(F)F)N3C=CN=C3 C#CCN(CC(=O)NCCC(F)=C(F)F)C(=O)C1=CN=CC(CC)=C1 CC1CCC(C(=O)NCC2CC(NC(=O)CC[C@@H1]3C(=O)NN=C3C)C2)CC1 C#C[C@](C)(NC(=O)[C@@H1](F)CC1CN(C(=O)CN2N=CN=N2)C1)[C@H1]3CCOC3 CO[C@](C)(C(=O)NC[C@@H1]1CCN(C(=O)C2=CC=C(CN=[N+1]=[N-1])O2)C1)C3CC3 O=C(NCCC1CN(C(=O)C2CCCCC2)C1)C3(F)CCCCC3 CSCC1=CC=CN=C1C(=O)N2CC[C@H1](NC(=O)C3(C#N)CCCC3)C[C@@H1]2C CC1=CSC2=NC(CC(=O)N[C@@H1](C)[C@@H1](C)NC(=O)CC(=O)NCC(F)(F)F)=CN12 CC(C)N1C=C(CN2C[C@H1](C(=O)O)[C@@H1](O)[C@H1]2C)N=N1 CN(CCCNC(=O)C12CC(C(C)(C)C)(C1)C2)C(=O)[C@@H1]3CCC[C@@H1]4CCCN34 COC1=CC=C2C=CC(C(=O)N(O)CC3=CN(CC(C)C)N=N3)=CC2=C1 CNC(=O)COCC(=O)N1C[C@H1](NC(=O)C2=CC=C(CC3CC3)S2)[C@@H1]4C[C@H1]41 CC1=C(CNC(=O)C2=CN(C)N=C2C3CCC3)C=CC=C1[N+1](=O)[O-1] CC1=NN=C(CCNC(=O)[C@@H1]2CO[C@H1](CNC(=O)C(C)(C)CN(C)C)C2)S1 CC1=CN(C(C)(C)C(=O)N2CC[C@@H1](OCCNC(=O)[C@H1]3CCCC3(C)C)C2)C=N1 CSC=CC(=O)N1CCCC12CCN(C(=O)C3=CC=C(F)C(C)=C3F)CC2 COCC1=CC(C(=O)N[C@H1]2CN(C(=O)C3=CN=C(O)O3)[C@]4(CCOC4)C2)=C(C)O1 CCCCO[C@H1](C)C(=O)N[C@H1](COCC)C(=O)NC[C@H1](OCC)C1CCC1 O=C(NC1CCCN(C(=O)CC(F)(F)C2=CC=CC=C2)C1)[C@H1](F)N3C=CC=N3 CN=C1[NH1]N=C(CC(=O)N2C[C@H1]3[C@H1]4CC[C@@H1]([C@H1]3C2)N(C(=O)CNC=O)C4)S1 COC1=NC(Cl)=C(C(=O)N2CCN(C(=O)C3=CC=CC(F)=N3)CC[C@@H1]2C)S1 CC1=NC(CCC(=O)NC[C@@]2(O)CCN(C(=O)C(=O)NCC3CC3)C2)=CS1 CC1=CC(C(=O)NC[C@]2(F)CCN(C(=O)C3(S(C)(=O)=O)CC3)C2)=NC=N1 COCCOCC(=O)N1C[C@@H1](NC(=O)C2=CC(C)=C(O)C(N)=C2)C[C@@H1](O)C1 CC1=CC(C(=O)N[C@@H1](C)CCCNC(=O)[C@@H1](C)NC(=O)CC(F)(F)F)=N[NH1]1 CC#C[C@@H1]CCNC(=O)C1=CC=NN2C(CC3=CC=CC=C3)=CC=C12 CCCCSCC(=O)NC[C@@H1](NC(=O)[C@@]1(C)CCC(=O)NC1)C2=CC=CC(C)=C2 CCC[C@@H1](C)CNC(=O)[C@H1]1CC[C@H1]2CC[C@H1]1N2C(=O)C3=C(C)C=NC=C3C CCC1=NC(C(=O)N[C@]2(CC)CCCN(C(=O)[C@H1](F)OC(F)(F)F)C2)=CO1 C#CCCCCC(=O)NCC1(C(=O)N2CCC[C@@](C)(OC)C2)CCCC1 CC1=CC=C(NC(=O)NC2CN[C@@H1]3CS(=O)(=O)C[C@@H1]3C2)C(Cl)=C1 COC1=CC=CC(F)=C1CC(=O)N(C)C[C@@H1](O)CNC(=O)C[C@@H1]2C[C@@H1]3C=C[C@H1]2C3 CCCN(C)[C@H1](C)CCNC(=O)CC[C@H1]1CC[C@@H1](NC(=O)[C@@H1]2C[C@@H1](F)C(=O)N2)C1 CCN(C(=O)CC1=CN=CC(C)=C1)[C@@H1](C)C(=O)N2CCC[C@H1](CC(C)C)C2 CC=1C=CSC=1C(=O)NC[C@@H1]2CN(C)CCN2C(=O)C[C@@H1]3C[C@H1](O)C34CCC4 CC1=CN=C(CC(=O)N[C@@H1]2CN(C(=O)C=3C=CSC=3C#N)C[C@H1]2C(F)F)S1 CC1=NC=CN1CC(=O)N[C@@H1](C)C[C@@H1](C)NC(=O)C=CC2=CC=C(O)C(O)=C2 C[C@@H1](SC1=CC=C(F)C=C1)C(=O)NC[C@@H1]2C[C@H1](F)CN2C(=O)C3=CN=N[NH1]3 C[C@@H1](S)C(=O)N1CC(CN(C)CC=2C=NN(C3CC3)C=2)C1 CC1=NC=C(CC(=O)N[C@H1]2COCCN(C(=O)C=3C=NN(C(C)C)N=3)C2)O1 CC[C@@H1]1C[C@H1](C(=O)NCC2(O)CN(C(=O)C(=O)C=CC3=CC=CS3)C2)CCO1 C[C@H1]1CCC[C@@H1](CC(=O)N2CC=C(C(=O)N[C@H1]3CCS[C@H1](C)C3)CC2)O1 COCCCOCCS(=O)(=O)N[C@H1](C)C1=NC(C2=CC=CN=C2)=NO1 C[C@H1](C(N)=O)N(C)C(=O)[C@@H1]1CCCCCCN1C(=O)C2=CC=CC(F)=C2F CCC(CC)C(=O)NC[C@H1](C)CN(C)C(=O)C=1N=CN(C(C)(C)C)N=1 CC(C)(CNC(=O)[C@H1](O)C1=CCCCC1)NC(=O)CCC2=CC=CC([N+1](=O)[O-1])=C2 CC[C@](C)(CNC(=O)C1=CC(F)=C(F)C=C1F)NC(=O)C2=NN=C(C(C)(C)C)S2 CCC1=CC=C(C(=O)N(C)CCCCCNC(=O)C=2C=CN3N=CN=C3C=2)N=C1 CCCCC1(C(=O)N2C[C@H1](O)[C@H1](NC(=O)C#CC3CC3)C2)CCC1 CC[C@@](C)(CO)C(=O)N[C@@H1]1CCCCC[C@H1]1NC(=O)C=2C=C(CO)N(C)N=2 CC=1N=NSC=1C(=O)NCC(C)(C)OCCNC(=O)C=2C=NN(CCCO)C=2 O=C(C=CC1=CC=C(Cl)C=C1)N2C[C@@]3(NC(=O)CC45CCC(CC4)C5)CC[C@H1]2C3 CC(C)C1=NC=C(C(=O)N2CCC(NC(=O)C3(N4C=NC=N4)CC3)CC2)N1C CO[C@@H1]1CN(C(=O)[C@H1]2CC(F)(F)C2(F)F)C[C@@H1]1NC(=O)C3=CC=CC(C)=C3F CC=1N=C(C2=CC=C([C@@H1](C)O)C=C2)N(C3=CC=CC=4N=C[NH1]C3=4)N=1 CCOC(CCCNC(=O)C1=CC(C2=COCCC2)=CN3C=CN=C13)OCC O=C(O)C=1OC=NC=1C2=CN(C3=CC=C(C(=O)NC[C@@H1]4CC=CCC4)C=C3)N=N2 COC1=NC=C(C(=O)N[C@@H1]2C[C@H1](OC)CN(C(=O)CC(=O)NC3CC3)C2)S1 CC(C)C[C@@H1](F)C(=O)NCCN(C(=O)C1=CC=C(CCF)C=C1)C2CC2 C[C@@]1(C(=O)NC2C=CCN(C(=O)[C@H1]3C[C@H1]4COC[C@H1](C4)C3)CC2)CCC(=O)NC1 COCC[C@H1](CC1=CC=CO1)NC(=O)C2=CC=CC(S(=O)(=O)NC[C@H1](O)COC)=C2 C/C=C/[C@H1]1CN(C(=O)[C@@](C)(O)CC(C)C)C[C@@H1]1C(=O)N2C[C@H1](F)[C@@H1](F)C2 CC(C)CCCCCC(=O)N1CCC(F)(CNC(=O)C[C@@H1]2CCSC2)CC1 C[C@@H1](C(=O)N[C@@]12CCCC[C@@H1]1N(C(=O)CN3CCOC3=O)CC2)S(C)(=O)=O C[C@@H1](CNC(=O)CCC=1N=C[NH1]N=1)CN(C)C(=O)[C@@H1]2CCC3=NC=CN3CC2 COC1(C(=O)N[C@@H1]2CN(C(=O)C3=CC=CC=C3CS(C)(=O)=O)C[C@H1]2OC)CCC1 CCC(=CC(=O)N[C@@H1](CC1CCC1)C(=O)NC[C@H1]2CCCN2C)CC O=C(NC[C@]1(F)C[C@@H1](NC(=O)C2=CC=C(Cl)C=C2[N+1](=O)[O-1])C1)C3=C[S@](=O)CCC3 O=C(C=CCN1CCCC1)N[C@H1]2CC3(CN(C(=O)C=CCF)C3)N4C=CN=C42 CC1=NC(C(=O)NCCOCCNC(=O)C2[C@H1]3CCC[C@H1]23)=CO1 COC(=O)C1=NN(C)N=C1C(=O)N(C)C[C@H1](C)NC(=O)[C@@]2(C)CC(C)=NO2 CC1=NN(CC(=O)N[C@H1](C)CNC(=O)[C@H1]2CCO[C@H1]2C)C(=O)N1C CC(C)C=1C=COC=1C(=O)N[C@@H1](C)[C@@H1](C)C(=O)N[C@H1](C)C2=CC=C(O)N=C2 CC(C)[C@H1](S)C(=O)N1CCC(C(=O)O)(C2=CC=C(Cl)C=C2)CC1 C[C@H1]1[C@@H1](C)N(C(=O)C=2C=CN(C)N=2)CCN1C(=O)CCC3=CN=CS3 C[C@H1]1OC(=O)N[C@H1]1C(=O)N[C@]2(C)C[C@H1](C(=O)NC3CC(N4C=CN=C4)C3)C2 COCC(=O)NCCC(=O)NC(C)(C)CNC(=O)[C@H1](C)N(C)C O=C(CC1=CC=NS1)N[C@@H1]2CCCC[C@@H1]2NC(=O)C=3C=CC(=O)N4C=3CCCC4 CCC[C@](C)(O)CC(=O)N[C@@H1]1CC[C@H1](CCC(=O)NCC2=C[NH1]N=C2C3CC3)C1 CC1=CC(C(=O)NCCC[C@@H1]2CCCCN2C(=O)[C@]34CCCC[C@@H1]3CCC4)=NO1 CC(C)[C@@H1](F)C(=O)N1CC[C@@](F)(CNC(=O)CCC2=CC=NC=N2)C1 CSC(C)(C)C(=O)N[C@H1]1C[C@H1](O)CN(C(=O)C2=CC=CC3=NC(Cl)=CC=C23)C1 CC=1C=NC(=NCCC(C)(C)NC(=O)[C@@H1](C)C2=CC=C(F)C(F)=C2)[NH1]C=1 [N-1]=[N+1]=N[C@H1]1CC[C@H1](C(=O)N2CC[C@@H1]2C(=O)N3[C@H1]4CCC[C@H1]3COC4)C1 C[C@H1]1CSCCN1C(=O)[C@H1](CC=2C=NN(C)C=2O)NC(=O)C3=NC=C[NH1]3 C=CC[C@H1](CC(F)F)NC(=O)/C=C/[C@H1]1CCCN1C(=O)[C@@H1]2CCC(=O)N2CC CC(C)C[C@]1(C(=O)N2CC(O)(CN(C)C(=O)CNC(N)=O)C2)CCNC1=O CN(C[C@@H1]1CCCN1C(=O)C2=CC=C(F)C(Cl)=C2)C(=O)C=3C=NN4C=3NCCC4 CS[C@H1]1C[C@@H1](C(=O)N2CCC(C)(C)[C@@H1](CNC(=O)[C@@]3(C)CCCO3)C2)C1 CC(C)(CCCNC(=O)C=C1CC1)C(=O)NC[C@H1]2CCCCS2 COC[C@@H1]1CN(CC2=CC=C(OC(F)F)N=C2C)C[C@@H1](C)O1 CC=1SC(C(=O)N2CC[C@@H1](C)[C@H1]2CNC(=O)CC3=NC(F)=C(F)C=C3F)=NC=1O CCCCNC(=O)[C@@H1](C1=NN(C)C(C)=C1Cl)N2CCC(C3CC(OC)C3)CC2 COC1=CC(Cl)=C(O)C(C(=O)NCC2N(C(=O)C34CC(C(C)(C)C)(C3)C4)C2)=C1 COC[C@@H1](CC(=O)N[C@@H1](CO)C1=CC=CN=C1)NC(=O)[C@@H1]2CC3(CCO2)CC3 CC(CO)(CO)C(=O)N1[C@H1]2C[C@H1]1CN(C(=O)C3=CN=C4C=C(Cl)C=CN34)C2 COC1=NSC=C1C(=O)NC[C@H1](C)N(C)C(=O)CC2=CC(C(F)(F)F)=N[NH1]2 CC(C)(O)C1=CC=NC(C(=O)N[C@@H1]2CCC[C@H1](NC(=O)CC#N)C2)=C1 CC1(C)[C@H1](NC(=O)[C@H1](C)N2C=C(Cl)C=N2)CCN1C(=O)COCC3CC3 NC1=CN=C(Cl)C=C1C(=O)N2CCC[C@@H1](NC(=O)CN3N=NC(=O)[NH1]3)CC2 C[C@@H1](C(=O)NCC(C)(C)CNC(=O)C1=CC=2SC=NC=2[NH1]1)C=3C=CSC=3 CC[C@H1](CCC(=O)N(C)C1CCN(OC)CC1)NC(=O)C2=CN=C(C(C)C)O2 CCN(CC(=O)N[C@@H1](CNC(=O)C1=CN=C(C(=O)OC)C=N1)CC(C)C)C2CC2 CC[C@H1](OC1=CC=CC=C1Cl)C(=O)N[C@@H1](C)CN(C)C(=O)C2(C)CC=CC2 CCCCOCC(=O)NC[C@H1](CC(=O)N[C@@H1]1CC(=O)N(O)C1)OC C[C@H1]1CN(C(=O)C[C@]2(O)CCOC2)[C@H1]1C(=O)N3[C@H1]4CCC[C@H1]3CC4 CCC1=NC(C(=O)NCCC[C@@H1](C)NC(=O)CNC(=O)C2=CC(F)=CC(F)=C2)=CS1 FC1=CC=CC2=C1CCN(C[C@@H1](O)C3(O)CCC3)CC2 CCC=1ON=CC=1C(=O)N2C[C@H1](C)C(NC(=O)C=3N=C(C)SC=3C)[C@@H1](C)C2 COCC[C@@H1](CNC(=O)[C@H1](OC)C=1C=NN(C)C=1)NC(=O)CC2=CCN(C)CC2 C=C1C[C@H1]1C(=O)N[C@@H1]2C[C@@H1]3C[C@@H1](NC(=O)C=4SC(F)=CC=4Cl)C[C@@H1]32 C#CC1=C[NH1]N=C1C(=O)N(C)CC(C)(C)NC(=O)C2=CN=C(C)N=C2CC CC=1C=COC=1C(=O)N[C@H1](CCN(C)C(=O)[C@H1](C)[C@@H1]2CCC(=O)N2)C(C)C CCC(C)(C)C1CCC(CC(=O)NC(C)(C)CCNC(=O)[C@](C)(CO)OC)CC1 CC[C@@H1](C)NC(=O)[C@H1](C1=CC=CC(NC(C)=O)=C1)N2CCN(CC(F)F)CC2 COC1=CC=NC(C(=O)NC[C@@H1]2CN(C(=O)C3(C)CC4(CCC4)C3)C[C@H1]2C)=C1 C=C[C@@H1](CC)CC(=O)NCC1=C[NH1]N=C1C(=O)N2CCC(CC)CC2 O=C(CC1CSC1)NC[C@@H1]2CC[C@H1](NC(=O)[C@@H1]3CC(=O)N(C4CC4)C3)C2 CC[C@@](C)(OC)C(=O)N1CC[C@H1]1CNC(=O)C2=C(Br)C=CC=C2OC CC(=CC(=O)NCC[C@@H1](NC(=O)C1=CC=C(C#N)[NH1]1)C(C)C)C(F)(F)C(F)(F)F CN1CCOC[C@]1(CO)CNC(=O)C2=NC3=CC=CC=C3[NH1]C2=O C=C[C@H1]1CN(C(=O)C=2C(C)=NN(C)C=2C)C[C@H1]1NC(=O)CCC3=NC(O)=N[NH1]3 C#CC1CCC(NCC2=C(C(=O)OC)C=NN2)CC1 C=CC[C@H1](CC(=O)N1CC[C@H1](N2C=NC=N2)C1)NC(=O)CN(C)C3CCC3 C=CC1(CC(=O)NCCCCNC(=O)C2=CC=CC(CN3CCCC3=O)=C2)CC1 CC(F)(F)C1=CC=C(C(=O)N[C@@H1]2COCC[C@@H1]2NC(=O)[C@@H1]3C(C)(C)C3(F)F)C=C1 O=C1NCC2=CC=CC(C(=O)N[C@@H1]3CCN(C(=O)C4=CC=C(Br)O4)C[C@H1]3CO)=C21 CCN(C[C@@H1](C)OC)C(=O)CC[C@H1]1C[C@H1](F)C1 O=C(COCCF)N[C@H1]1C[C@@H1](CNC(=O)C[C@@H1]2CC[C@H1](C(F)(F)F)N(C)C2)C1 C[C@@H1]1CCC[C@@H1](C)N(C(=O)C2=CC(C=3C=CN4C=NN=C4C=3)=CN(C)C2=O)C1 C[C@H1](C(=O)N[C@@H1]1CN(C(=O)C2(C#N)CC=CC2)CC[C@H1]1CO)C3=CC=C(F)C=C3 O=C(NC[C@]1(F)C[C@@H1](NC(=O)C(F)(F)C2CC2)C1)[C@H1]3CC4=CC(Cl)=CC=C4O3 COC1=CC(N2C[C@@H1](C)C[C@H1](NC(=O)C3=C[NH1]C=C3C)C2)=NC=N1 O=C(CCCF)NC1CCC(CNC(=O)C2=CC=C(OC3CCOCC3)C=C2)C1 CN(C(=O)CNC(N)=O)[C@H1]1CCN(C(=O)CC2(O)CCCC2)CC13CC3 CCOC(=O)N1CCN([C@H1](C(=O)NC(C)C)C2=CC=C(OC)C(F)=C2)CC1 CC1=NOC(C2=CC=NC(N3CC[C@@H1](N(C)C(=O)[C@@H1]4CCCSC4)C3)=N2)=N1 C[C@@H1](C(=O)NCC(C)(C)C1=CN=CC=N1)[C@@H1]2CCN(C(=O)OC(C)(C)C)C2 CC[C@H1](C)C(=O)C(=O)NC[C@@](C)(O)CNC(=O)[C@H1]1C[C@H1]1C(N)=O C=C[C@@H1](O)C(=O)NCC[C@@H1](NC(=O)C1=C(C)C=NN=C1O)C(C)C CC1=CC=C([N+1](=O)[O-1])C=C1C2=CSC(C(=O)N=C3C=C(Cl)N=C(Cl)[NH1]3)=N2 CNC1=NC(CCC(=O)N[C@H1]2CCN(C(=O)C3=CC=C(C(N)=O)C=C3)CC2(C)C)=C1 CCC1=NC(C(=O)N2C[C@@H1]3C[C@H1](NC(=O)[C@H1]4C[C@@H1]5CC[C@H1](C4)[C@H1]5O)[C@H1]2C3)=CO1 CC(C)C(=O)N(C)CC(=O)N1CC(O)([C@H1](F)C(=O)N2CCOC[C@@H1]2C(C)C)C1 COCC=CC(=O)NC[C@@H1](CC(C)C)NC(=O)CC1(O)CCC1 C[C@H1](CNC(=O)C1(O)CCSCC1)C(=O)NCCCOCC2CCC2 C#CC1(N(C)C(=O)[C@H1](CCSC)NC(=O)CN2CCSCC2)CC1 C[C@H1](CCNC(=O)C=1C=NN(CCO)C=1)NC(=O)C2=CC=NC=C2OC(C)(C)C CC(C)OC1=CC=C(F)C(C2=CN=CN=C2C(=O)NCC3=CC(Br)=CC=C3O)=C1 CC[C@H1](NC(=O)[C@H1](C)[C@H1](O)[C@H1](C)CC)C1=CC=C(F)C=C1 O=C(C1CC2(C1)CN(C(=O)C3=CC=NC(C(F)(F)F)=C3)C2)NCC4=CC=CC=N4 CC(C)C1=NN=NN1CC(=O)N(C)[C@@H1]2CCCCN(C(=O)[C@]3(C)CCC(=O)N3)C2 CCCC(F)(F)C(=O)N(C1CC1)[C@@H1](C)C(=O)NCC2=CC(F)=CC=C2O C[C@H1](CN(C)C(=O)C1([C@H1]2CCCO2)CC1)NC(=O)C3CCC4(CCCC4)CC3 COC1=NC(Cl)=CC=C1C(=O)N[C@H1](C)C[C@H1](C)NC(=O)C=2C=CC(=O)N(C)C=2 CC1=NC2=C(S1)C[C@@H1](C(=O)NCC3=C(Cl)C=CC=C3Cl)CC2 C[C@H1]1CCOC[C@H1]1C(=O)N2CC3(C=C(C(=O)NCC4=CN(C5CC5)C=N4)CO3)C2 CN1N=CC(Cl)=C1CC(=O)N2CCC[C@H1]([C@@H1]3CCN(C(=O)CN4N=CN=N4)C3)C2 C[C@](CNC(=O)[C@@H1](C#N)C1CC1)(NC(=O)C2=CC(Br)=C(Cl)S2)C3CC3 NC(=O)NCC(=O)NC[C@@H1](CO)NC(=O)C1CC[C@H1](C2=CC=C(Cl)C=C2)C1 C[C@H1](SC1=CC=CC=C1C(=O)OC(F)(F)CF)C2=NC=C(C(F)(F)F)[NH1]2 CC=CCC(=O)N1CCC(CNC(=O)[C@@H1]2C[C@H1]2CC(C)C)(COC)CC1 CCOC(=O)[C@H1](CC)N(C)C(=O)N[C@@H1]1CC[C@](C)(CC(C)C)C1 CC=1SC=CC=1C(=O)N2CC[C@H1](NC(=O)[C@H1](C)CF)C[C@H1]2C C=CCC1(NC(=O)CSC2=NN=CS2)CN(C(=O)[C@H1]3CC=CC4=CC=CC=C43)C1 COC1=C(C)C=NC=C1NC(=O)NCC=2N=CN(C)N=2 CP(C)(=O)CC(=O)N1CCO[C@@H1](CNC(=O)C=CC2=CC=C(Cl)S2)C1 CC(C)OC1=CC=C(C(=O)N[C@@]23C[C@@H1]2CN(C(=O)C4CC5(CC(F)C5)C4)C3)C=N1 O=C(N[C@@H1]1C[C@H1]2CC[C@H1]1N(C(=O)C=CC3=CC=C[NH1]3)C2)[C@H1]4CC(=O)N(C5CC5)C4 C[C@@H1](CCNC(=O)COC(F)F)N(C)C(=O)[C@H1](C1=CC=C(F)C=C1)C2CC2 C[C@@H1]1C[C@@H1](CNC(=O)C(F)(F)C2=CC=CC=N2)CN1C(=O)CCCNC(N)=O CC(C)=C(C)C(=O)N[C@@H1]1C[C@@H1]2C[C@H1]1N(C(=O)COC3=CC=C(C#N)C=C3)C2 COC(=O)C1=CC(F)=NC(N2C[C@@H1](C(=O)OC)CC(C)(C)C2)=C1 C#C[C@]1(NC(=O)CCCCCNC(=O)C2=CC(C)=C(O)N=N2)CCOC1 CC[C@@H1](C(=O)N(CC)CCN(CC)C(=O)CCN1CCOC1=O)[C@H1](C)O CC1=NOC(C(C)C)=C1C(=O)N2CC[C@@H1](NC(=O)C3=COC(C(C)C)=N3)[C@H1](C)C2 C[C@H1]1CCCN1CC(=O)N(CCNC(=O)CN2CCC3=CC=CC=C32)C4CC4 C[C@@H1]1[C@@H1](NC(=O)CC(C)(C)CNC(=O)CN2CCOCC2)CCN1C CC1=NC(N[C@@H1](C)CN(C)C(=O)C2=CN=C3C(=C2)CCCO3)=CC(C(F)(F)F)=N1 CCC1=C(C(=O)N2CC=C[C@@H1]2C(=O)N(C)CCC(C)(C)O)C=CN1C C[C@H1]1CN(CC2CC3(CCN3C(=O)C4=CC=CC=C4CO)C2)CC[C@@H1]1O CO[C@H1](C)[C@@H1](C(=O)N1CCC([C@@H1](C)C(=O)NCC2=NC=CN2C(C)C)CC1)N(C)C C=C=C[C@@H1](C)C(=O)NC1(C2(O)CCN(C(=O)C[C@H1](O)CC)CC2)CC1 CC[C@@H1](C(=O)NC[C@@H1](C)N1CCN(C(=O)[C@@]2(C)CCNC2=O)CC1)N3C=CC=N3 COC1=CN=CC(CN2CC(C3CCN(C(=O)[C@@H1](C)C4=CC=CS4)CC3)C2)=C1 C=C[C@]1(C(=O)N[C@@H1](C)C(C)(C)O)CCN(C(=O)C[C@@H1]2C[C@H1]3C[C@H1]3C2)C1 CC=C(F)C(=O)NCCCC[C@@H1](C)NC(=O)CN1C=CC2=CC(Br)=CN=C21 CC(=O)NC1=CC(C(=O)N[C@@H1](CNC(=O)C2=CN=C(C)[NH1]2)C(C)C)=CC=C1F CCN1CCO[C@H1](C(=O)NC[C@@]2(C)CCCN2C(=O)COCCO)C1 COC(=O)NCC(=O)N[C@@H1]1C=C[C@H1](CNC(=O)[C@@H1](C)C2=NC(F)=CC=C2Cl)C1 O=C(C[C@@H1]1COCCO1)NCC(F)=C2CN(C(=O)[C@@H1](C3=CC=CC=C3)C4CC4)C2 CCC1=NO[C@H1](CC(=O)N2CCC3(CC2)C[C@@H1](NC(=O)C4=CON=C4C)CO3)C1 C=CC[C@@H1](CNC(=O)CC[C@H1](C)CN(C)C)NC(=O)CSC1=NN=NN1C CCCS(=O)(=O)N[C@H1](C)C(=O)N[C@@H1](C)CN1C=C(CNS(=O)(=O)CC)N=N1 CCC=1[NH1]N=C(C(=O)NC[C@]2(C)CCCN(C(=O)C3=COC=C3C)C2)C=1C C=CCC[C@H1]1CCCN(C(=O)COC2CN(C(=O)CCC3CCC3)C2)C1 COCCN(CCNC(=O)C1=CC=CC(F)=C1Br)C(=O)C(N)=O C[C@H1]1COCCN1S(=O)(=O)C2=CC=C(C#N)C(N3CC[C@H1](OCCO)C3)=C2 CC=1C=C[NH1]C=1C(=O)N[C@H1]2CCC[C@@H1](NC(=O)CC3=CC=C(F)C=N3)CC2 COCC[C@H1](CNC(=O)C1=CN=CC(OC)=N1)NC(=O)C(F)(F)C(C)(C)O COC1(CC(=O)NC[C@H1]2CC[C@@H1](C3CC3)O2)CN(C(=O)CN4C=NN=C4O)C1 C#CC1CCN(CC(=O)N(C[C@H1]2CCCN2)C3=NC=NC=C3CC(=O)O)CC1 CC1=N[NH1]C(=NC(=O)C2=N[NH1]C3=CC(C4=CC=C(C)C=5C=C[NH1]C4=5)=CC=C23)O1 C=CC[C@@H1](OC)C(=O)N1CCC[C@@H1](CCC(=O)NC=2C=NN(C(C)C)C=2)C1 CO[C@H1](CC(C)(C)C)C(=O)NCC1(CNC(=O)C=2C=C(C(F)F)[NH1]N=2)CCCC1 CCCC1=CC(C(=O)N2CC[C@](O)([C@@H1](C)CNC(=O)C3(C(C)C)CC3)C2)=NO1 CC1=CC=C(S(=O)(=O)N2CCN(C(=O)[C@@H1]3NCCC34CCCCC4)C[C@H1]2CCO)S1 CCC1=C[NH1]C(=N)N=C1NCC2=CC=C(F)C(C3CC3)=C2 CCCC(C)(C)CC(=O)NC(C)(C)/C=C/C(=O)N[C@@H1]1CCC[C@@H1]1C#N O=C1CCN(CC(=O)N2[C@H1]3CC[C@@H1]2C[C@H1]3CNC(=O)[C@H1]4COC(=O)N4)C(=O)N1 CN1N=NC(/C=C/C(=O)N[C@@H1]2[C@H1](CNC(=O)C3=CCOC3)CCC24CCC4)=N1 CCC(=O)N[C@@H1](CNC(=O)C1=CN=CC(C(F)F)=C1)C2=CC=CC(OC)=C2 C[C@H1](C(=O)N[C@@H1]1[C@H1](C)C1(C)C)N(C(=O)C=C[C@@H1]2CCCN2C)C3CC3 CC(C)N1C=NC(C(=O)N2CC3CC2(C(=O)NC[C@@]4(O)CCOC4)C3)=C1 CCC=1N=NSC=1C(=O)N[C@H1](C)[C@H1]2CN(C(=O)C3=NC=CC(Cl)=C3F)CCO2 CCC1=CC(=NC(=O)C[C@H1](O)C2CCCC2)[NH1]N1 CCN1N=NC(C(=O)N[C@H1](C(=O)N[C@H1](C)CO)C2=CC=NN2C)=C1C CCC(=O)CCC(=O)NCC1=NOC(CC(=O)OC)=N1 CCC1=NC(Cl)=C(F)C(=NC[C@H1](C)NC(=O)C2=CC(CC)=C(C)S2)[NH1]1 N=C1N=CC(C(=O)NCC[C@H1]2CCCN(C(=O)C3CC(C4CCC4)C3)CC2)=C[NH1]1 C[C@@H1](C(=O)NC[C@H1]1CC[C@H1](C(=O)N[C@H1](CO)[C@H1]2CCOC2)CC1)N3C=CC=C3 CC=1SC(O)=NC=1C(=O)NC[C@H1]2C[C@@H1](CNC(=O)C(C)(C)CC(C)C)CO2 C[C@@H1](SC1=CC=C(Cl)C=C1)C(=O)N2CCC[C@H1](NC(=O)C3=CN4C(=N3)CCC4)C2 CN(C)C(C)(C)CCC(=O)NC(C)(C)[C@H1]1CCCN1C(=O)C2=CC=C(C(F)F)O2 C[C@H1](CNC(=O)C1=CC=NC(Cl)=C1F)N(C)C(=O)C2=CC=C(C3CCCCC3)O2 CC1=C(C(=O)N[C@@H1]2CC[C@H1]2NC(=O)C(=O)N3CC[C@H1](C)C3)N=CN1C CC(C)C1=CC=C(C(=O)N2CC[C@@H1]3[C@@H1](NC(=O)C4=C[NH1]C(Br)=C4)[C@@H1]32)C=N1 C=CCC(CC=C)C(=O)N[C@](C)(CNC(=O)[C@H1]1SCC=C1C)C2CC2 CSCC1(CC(=O)N2CC[C@H1](C3(NC(=O)COCCF)CC3)C2)CC1 CC#CCN(C(=O)C(=O)NC1=CC([N+1](=O)[O-1])=CC=N1)C2CCCC2 C[C@H1]1CCC[C@@H1](N2C=C(CCC3CN(C(=O)[C@H1](F)C4(O)CCCC4)C3)N=N2)C1 C=CCCCN(C)C(=O)[C@H1](CC1CCC1)NC(=O)C=2N=C[NH1]N=2 CC(=O)N(C)CCCC(=O)NCC[C@@H1](O)CNC(=O)C1=CSC(C(C)(F)F)=N1 CCN1N=CC(Cl)=C1C(=O)NCC[C@@H1](O)CNC(=O)[C@@H1](C)C2=CN=CN=C2 COCC1=NOC=C1C(=O)N2CC=C[C@@H1]2CNC(=O)C=3SC=CC=3C#N C=CC[C@H1](CC)C(=O)N[C@@H1](C)/C=C/C(=O)NCC1=NN=C2N1CCC2 CCCN(C(=O)CCC=1C=CN(C)N=1)[C@@H1]2CCN(C(=O)[C@@H1]3C[C@H1]3C(F)F)C2 COC[C@@H1]1CCN(C(=NCCC2=CC=CO2)NCC3=NOC(CO)=N3)C1 CN(C(=O)CCCC(F)(F)F)C1CN(C(=O)[C@H1]2CCC3=NC=C(Br)N3C2)C1 CN(C)C(=O)[C@@H1](CC1=CC=CC=C1)NC(=O)CN2CC3(C[C@H1](O)CO3)C2 CC(C)(CCCNC(=O)C1=CC=C(C(C)(C)C)S1)NC(=O)COC[C@H1]2CCOC2 CCNS(=O)(=O)CC(=O)NCC1CC(NC(=O)[C@H1]2CCCOC2)C1 CN1N=NC(CNC(=O)C[C@H1](CC2CC2)NC(=O)CC3C[C@H1]4C[C@@H1]4C3)=N1 CCOC(=O)CN1N=C(C)C(CNC(=O)NC(C)(C)CCS(C)(=O)=O)=C1C COC[C@](C)(OC)C(=O)NC[C@@H1](CC1CCCC1)C(=O)N(C)CC[C@H1]2CCCN2C C[C@@H1](NC(N)=O)C(=O)N[C@@H1]1CC[C@H1]2C[C@H1]1CN2C(=O)[C@H1]3CNC4=CC=NN4C3 CCN=C1C=C(CNC=2[NH1]C(=N[C@@H1](C)CC3=NN=CN3C)N=C4C=2C=NN4C)S[NH1]1 COCC1(C(=O)NCC2(NC(=O)C3=CC=CC(C#N)=C3C)CCCCC2)CCC1 CCC(CC)CC(=O)N1CC[C@](F)(CNC(=O)C2=CC=CC3=C2OCCC3)C1 CS[C@H1]1C[C@H1](C(=O)NCCCC[C@H1](C)NC(=O)C[C@@H1](O)CC(C)(C)C)C1 CNCC(=O)N1CCC[C@@H1](CN)C1 CO[C@H1](C(=O)N1CC[C@@H1]([C@H1]2CNC(=O)C2)C1)C3CCC3 O=C(NC1=CN=CC=C1Br)[C@H1]2CCN2S(=O)(=O)/C=C/C3=CC=CC=C3 CC[C@H1](CN(C)C(=O)C1=CC2=C(C)C=C(F)C=C2[NH1]1)NC(=O)C=3N=NN(C)C=3N C=CC[C@@H1](NC(=O)C1=COC(OCC)=N1)C(=O)N2CCC(OC)CC2 CSCC(=O)N[C@@H1]1COCC[C@@H1]1NC(=O)C2=NC=C([N+1](=O)[O-1])C=C2Br C=C=C[C@@H1](C)C(=O)N1CCC([C@@H1]2C[C@H1]2NC(=O)C3=CC=C(F)C(F)=C3)CC1 C#CCCCC(=O)N1CCC2(CC1)C[C@@H1](C)N(C(=O)[C@H1]3CC[C@H1](C(C)C)CC3)C2 CC1=CC(C(=O)N[C@@H1]2CC[C@H1]3CN(C(=O)CC4CC4)C[C@H1]3C2)=C5C=NN(C)C5=N1 C=C(C)C[C@H1](NC(C)=O)C(=O)NCC(C)(C)CNC(=O)C(=O)C=1C=NN(C)C=1 CCC1=CC(C(=O)NC[C@H1]2C[C@H1](NC(=O)C=3[NH1]C(O)=NC=3C)C2)=CC=N1 CC(C)OCC[C@H1]1CN(C2=NC(=NCC3(C)CCCC3)[NH1]C=4C=CSC2=4)CCO1 CN1CC[C@H1]2CC[C@@H1](C1)N2C(=O)[C@@]34C[C@@H1]3CN(C(=O)C5=CN(C)C(=O)N5C)C4 COC(=O)C1(NC(=O)/C=C/CNC(=O)[C@@H1]2CCCS2)CC1 CN1C=C(CCCNC(=O)[C@@H1]2CCOCCN2C(=O)CCN3C=NN=N3)C=N1 CCCC(=O)NCC(=O)N1CC=C(C(=O)N2CCC3(CSC3)C2)CC1 CC[C@@H1](SC)C(=O)N(CCNC(=O)CN(C)S(N)(=O)=O)C1CCCC1 CC1(C)[C@H1]2C[C@H1](C(=O)N3CC[C@@H1](N4C=C(CNC(=O)C5CC5)N=N4)[C@H1](O)C3)C[C@H1]21 CC=1C=C(COCC(=O)NC2CCC(C)(NC(=O)[C@H1](C)SC(F)(F)F)CC2)ON=1 CCN1C=C(Cl)C(C2=CN(C3=CSC([C@H1](C)OC)=C3)N=N2)=N1 C=CC1(C(=O)NC2CCN(C(=O)[C@H1](C)CC3=CC=C(OC)C=C3)CC2)CCC1 CC(C)O[C@@]1(CN(C)N2CCC(N3C=NC4=CC=CC=C4C3=O)CC2)CCOC1 C[C@@H1](CC(=O)C1=CC=C(Cl)C=C1)C(=O)N2CC(N(C)C(=O)CC3CCCCC3)C2 C=CC(C)(C)C(=O)N1CCOC[C@@H1](CNC(=O)C=2SC(F)=CC=2C)C1 CC1=CC=C(C)C(C(=O)N2CC3[C@H1](CNC(=O)CC45CCC(CC4)OC5)C2C3)=C1 CC1=CC(C(=O)N2C[C@H1]3C[C@H1]2C[C@H1]3NC(=O)CC4=NN=CN4C(C)C)=CC(O)=N1 O=C(N[C@H1]1C[C@@H1](O)CN(C(=O)C2=CSC(CO)=N2)C1)/C(Cl)=C/Cl CO[C@@H1](CCSC)C(=O)N1CCN(CCNC(=O)[C@@H1]2CCC23CCOCC3)CC1 CN(C)[C@@H1](C(=O)N[C@H1](CO)C1CCN(C(=O)[C@]2(C)C=CCC2)CC1)C(C)(C)C CCCNC(=O)[C@@H1](C1=CC=C(C2=CC=CC=C2)O1)N3CCC[C@](O)(CC)CC3 C[C@@H1]1CC[C@@H1](NC(=O)C=2C=C[NH1]C=2C3CC3)CN1C(=O)[C@@H1]4CCCCC4(F)F COC1=CC=C(C(=O)NC[C@@](C)(NC(=O)C2=N[NH1]C(O)=N2)C3CC3)S1 CON=CC(=O)NCC(C)(C)CN(C)C(=O)C1=CC=C([N+1](=O)[O-1])[NH1]1 CCO[C@@H1](C(=O)NCCCOC1CCN(C(=O)C2CC(CC)C2)CC1)C3CC3 COCCN(C)CC(=O)N1CCN(C(=O)C=2SC=CC=2C)C3(CC3)C1 CC(C)(C)OC(=O)NC[C@@H1]1CC[C@@H1]2CN(C(=O)NC=C3CCC3)CC[C@H1]2C1 CC[C@@]1(C(=O)NCC2=CC(C)=CC(O)=C2)CCN(C(=O)[C@@H1](C)CSC)C1 C=CCCCCCC(=O)N1CC2(CCN(C(=O)C=3C=NN(CC)C=3Cl)C2)C1 CC1=NC(Cl)=C(C)C(N2CCCN(C(=O)[C@H1](O)C3=CC=C(Cl)C=C3)CC2)=N1 CCS(=O)(=O)CC(=O)N1C[C@H1](O)[C@H1](NC(=O)C#CC(C)C)C1 O=C(C=C1CCC1)N[C@H1](CN=C2C=C(F)N=C[NH1]2)C3=CC=CC=C3F CC(=O)C1=CC=C(C(F)(F)F)N=C1N2CCN(CCNC(=O)C3CC=CC3)CC2 CN(CC1CN(C(=O)CN2C=CN=N2)C1)C(=O)C3=CC(F)=C(F)C=C3Cl CCC1=CC=C(C(=O)NC2(CCNC(=O)C=3C=C(C4CCC4)[NH1]N=3)CC2)C(C)=N1 CC(C)C=1C=C(C(=O)N(C)[C@@H1]2C[C@H1]3C[C@@H1]2N(C(=O)C=CC4=NC=C[NH1]4)C3)N(C)N=1 CC1=CC(CC(=O)N[C@H1]2CN(C(=O)[C@@H1]3[C@H1](C#N)C3(C)C)C[C@H1]2C)=CC=C1Cl CCC#CCCNC(=O)[C@@H1](CNC(=O)C1=CSC=C1CC)C(C)(C)C CC(C)(C)C[C@@H1](O)C(=O)N[C@H1]1CC[C@@H1](NC(=O)CNC2=CC=C(Cl)C=C2Cl)CC1 CC1=CC(N(C)C[C@H1]2CCO[C@@H1]2C)=NC(N3CCC(N4CCCCC4=O)CC3)=N1 CC1=CC=CN=C1C(=O)N2CCC23CN(C(=O)CC4=CC=CC(Cl)=C4F)C3 CCC1=CC=CC=C1OCC(=O)N[C@@H1]2CN(C(=O)C=3C=NOC=3C)C[C@@H1]2O CC[C@](C)(O)C(=O)N[C@H1](CO)CCCNC(=O)[C@@H1](NC(C)=O)C(C)C CCOC1=CC=C(/C=C/C(=O)NCCNC(=O)[C@H1](C)N2C(=O)CCC2=O)C=C1 C=CCN(CC)C(=O)C[C@H1]1CCC[C@@H1](NC(=O)C2CC(CCC)C2)C1 C#CCSC1=CC=CC(C(=O)NC[C@@]2(C)CN(C(=O)[C@H1]3CCO[C@H1]3C)CCO2)=C1 CCC[C@H1](C(=O)N(CC)C[C@@H1](C)NC(=O)C1=CC(C2CC2)=NC=N1)N(C)C CC1=CC=C(C(=O)N2C[C@@H1]3C(CNC(=O)C[C@H1]4CCCC(C)(C)C4)[C@H1]3C2C)N=C1 CC[C@@H1](CNC(=O)[C@H1](C)C1CC1)NC(=O)[C@@H1](O)C2=CC=CC=C2Cl COC=1C=C(C(=O)N2[C@H1]3CC[C@@H1]2C[C@@H1](CNC(=O)COC[C@H1]4CCCO4)C3)ON=1 CC1=CC=CC([C@@H1]2CCCN2C(=O)N3CCN(C(=O)C4CCCC4)CC3)=C1 CCC1=C(C(=O)N2CCC(N(C)C(=O)[C@@H1]3O[C@H1]4CC[C@H1]3C4)CC2)SCCO1 COCC1(CCNC(=O)[C@@H1]2CN(C(=O)[C@@](C)(O)C3CC3)CCO2)CC1 CC1=NC=C(CC(=O)N2C[C@@H1](NC(=O)[C@H1](C)OCC3=CC=CC=C3)CC[C@H1]2C)[NH1]1 COCCSCC(=O)N1CC(C2CN(C(=O)CC3=CC=CN=C3OC)C2)C1 CC1=CC(C)=NC(C2=CC=C(Cl)C=C2)=C1NC(=O)CCN3CCCCCCC3 O=C(C1=CC=CN2C=NC=C12)N3C[C@H1]4CN(C(=O)C5(O)CCC5)C[C@H1]4C3 N=C1[NH1]N=C(C(=O)NCC2=CSC(NC(=O)C[C@H1]3CCCCCC3(F)F)=N2)[NH1]1 C[C@@H1]1CN2CCC[C@@H1]2CN1C(=O)CC3(N(C)C(=O)[C@@H1](C)N4CCCC4)CC3 CN(CC1=CCCOC1)[C@@H1]2COCC2(C)C CCC1=CSC(C(=O)N2CCN(C(=O)CC3=CC=C(C#N)C=C3)[C@@H1](CC)C2)=N1 CCN(CC)CCC(=O)N[C@@H1]1C[C@H1]1[C@@H1]2CCCN(C(=O)CC3=CN=NN3C)C2 CSC1=CC=C(NC(=O)C2=CC=C(CCNCC3=CC=C(F)C=4C=COC3=4)C=C2)S1 COC1=CC=C(Cl)C=C1C(=O)NCCN(C(=O)CC2=CC=C(C)C=C2Cl)C(C)C CCC[C@H1](C(=O)NCC1=CCN(C(=O)[C@H1]2CC23CC(C)(C)C3)CC1)C(C)C CCO[C@H1](C(=O)NCCN(C)C(=O)C=1C(C)=NN(C)C=1N2C=CC=N2)C3CCC3 COC1=CC=C(C(=O)N2CC3(NC(=O)C=4C=C([C@@H1]5C[C@H1]5C)ON=4)CC2C3)C(C)=C1 CCOCC1=NC(C)=C(C(=O)NC[C@@H1]2C[C@@H1](C)N(C(=O)C(=O)NC(C)C)C2)S1 CN1C(C#N)=CC=C1C(=O)N2CC[C@](CF)(C(=O)NCC3=CN=NN3C)C2 O=C(C1CC1)N2CC[C@@H1]3[C@H1](CCCN3C(=O)C(=O)C4=CC=C(O)C=C4)C2 CCC[C@]1(NC(=O)CC2=CSC(C)=C2)CCCN(C(=O)[C@H1]3COCCN3C=O)C1 C=CC[C@@]1(C(=O)N2C[C@H1](OC)C[C@H1]2CO)CCN(C(=O)C=3N=CN(C)N=3)C1 O=C(C=1C=CC2=N[NH1]C=C2C=1)N3C[C@@H1]4CC[C@@]4(C(=O)N5CCCSCC5)C3 C[C@H1](CC1CCCC1)C(=O)N2CC=C(CNC(=O)C[C@@H1]3CCCOCC3)CC2 C[C@@H1](C(=O)N(C)C(C)(C)CC(=O)NC[C@@H1]1CC(C)(C)CCO1)N2C=NC=N2 C[C@H1](CC(=O)N[C@@H1]1CCN(C(=O)C2=C(Cl)CCCC2)CC1(C)C)C(F)(F)F CN(C[C@H1]1CCCN1C(=O)C2=CC=C(C(F)(F)F)C=C2)C(=O)[C@H1](C#N)C(C)(C)C CCOC1=CC=CC=C1CCNC2=CC=CC=C2C=3N=N[NH1]N=3 C=CN1N=NC=C1C(=O)NC[C@H1]2CO[C@@H1](CNC(=O)CCCC3=CN=N[NH1]3)C2 CC[C@H1](C)C(=O)N(C)CC[C@H1](NC(=O)C1=CN(C)C(=O)C=C1C)C(C)(C)C CCC1=NC(C(=O)NCCO[C@H1]2CCN(C(=O)C3=NC(C)=CC=C3F)C2)=CO1 COC(=O)C=1C=C(C)C=C(NC(=O)C2=NC=CC=N2)C=1C C=C[C@](C)(O)C(=O)NC[C@@H1]1C[C@H1]1CNC(=O)C2=CN=C3N=C(O)C=CC3=C2 C#C[C@](C)(NC(=O)[C@H1]1CC(=O)CN1C(=O)[C@H1](C#N)C(C)(C)C)C2CCC2 CCCC(CCC)CC(=O)N1C[C@@H1](C)CN(C2=NN=C(CC(F)(F)F)S2)[C@@H1](C)C1 CCN1N=CC(C(=O)N[C@@H1]2CCCCN(C(=O)C3=CC(C#N)=CC=N3)C2)=C1C CCNC(=O)[C@H1]([C@@H1]1CCOC2(CCCC2)C1)N(C)CCNC(=O)OC(C)(C)C CC=1SC(C(=O)N2CCCN(C(=O)C3=CON=C3C)[C@H1](C)C2)=CC=1CS(C)(=O)=O CCC1=CN=C2C=CC=CC2=C1C(=O)N3CC4(CC(NC(=O)[C@](C)(O)CC)C4)C3 C=CCC[C@H1](NC(=O)C1=CC=C(C(F)F)O1)C(=O)NCCC2=CC=NC=N2 CN1CC[C@@H1](CN(C)C(=O)[C@@H1]2CSCCN2C(=O)C3=C[NH1]C(C(N)=O)=C3)C1 CCOC(=O)C1(C(=O)NC[C@H1]2C3=CC=CC=C3S(=O)(=O)N2C4CC4)CCC1 C[C@H1]1CN(C(=O)C(F)=CC2=CC=CN2C)C[C@@H1]1NC(=O)CCC3=NC=CS3 CCC(C)(C)NC(=O)[C@H1](C1=NC(Br)=CS1)N2CCCC[C@@H1]2C COC[C@@H1](C1=CC=CC=C1)N(C)[C@H1]2CCN(C(=O)C=C(C)C(C)C)C2 CSC1(C(=O)N[C@@H1](C)CN2CCCCC2)CN(C(=O)CC3=CC=C(O)C=N3)C1 CCOC[C@H1](C)C(=O)N1CCC[C@H1](N(CC)C(=O)CSC2=NN=CN2C3CC3)C1 CSCCC(=O)N1CC[C@H1](NC(=O)C2=C(C)C=C(C)C=C2N)C1 CC(C)COCCC(=O)NC[C@H1]1CN(C(=O)[C@]2(C)CCCC2(F)F)CCC1(F)F CC(C)[C@H1](C)CN=C1C=CN=C(NCC2=CC=C(CC(N)=O)C=C2)[NH1]1 CC[C@@H1]1CC[C@H1](C)N(C(=O)C2=CON=C2CNC(=O)[C@H1](O)C3=CC=CO3)C1 O=C(NC[C@H1]1C[C@@H1](NC(=O)[C@]2(Cl)CC2(F)F)C1)C=3C=CC4=C[NH1]N=C4N=3 COCC=CC(=O)N[C@H1]1C[C@H1](CNC(=O)C2=CC(C(=O)OC)=CO2)C13CCC3 CC1=CC(C(=O)N2CC[C@@H1](C(=O)N[C@@H1](CO)C3CCC3)C24CC4)=NC=C1C#N CCC[C@@H1](O)C(=O)N1CCN(C(=O)[C@H1](OCC(F)(F)F)C2=CC=CC=C2)[C@H1](C)C1 CC1=NC(C(C)C)=NC=C1C(=O)N2CC[C@](CO)(NC(=O)C=3C=N[NH1]C=3)C2 CCC=1SC(C(=O)N[C@@H1](C)C2CN(C(=O)C3=CN(C(C)C)C=N3)C2)=CC=1C CC[C@@H1](COC)C(=O)NC[C@]1(F)C[C@@H1](NC(=O)CC2=CC=C(Cl)C=C2)C1 CCC(F)(F)C1(C(=O)N[C@H1](C)C[C@H1](C)NC(=O)CCCCN2CCOCC2)CC1 O=C(N[C@@H1]C1CC=C=CC=C(Br)C=CC1)C2=CC=C3SC=C(Br)C3=C2 CCC1=CC=CC(C(=O)N(C)C[C@@H1]2CCN(C(=O)CC[C@H1]3CCCN(C)C3)C2)=N1 CC(C)CCCCCC(=O)NCC[C@@H1](C)N(C)C(=O)CCC1=CC=NC=C1 O=C(CCC(F)(F)F)N1CCOC2(CCS(=O)(=NC(=O)C[C@H1]3CC=CCC3)CC2)C1 C#CCC(C)(C)C(=O)NCC1(N(C)CCOC)COCC1 COC[C@H1](C)[C@H1](C)C(=O)N[C@H1](C)C1(C(=O)N[C@H1](C)C2=NC=CC(C)=N2)CC1 C=C=C[C@@H1](C)C(=O)N1[C@H1]2CC[C@@H1]1[C@H1](CO)N(C(=O)CN(C)C(N)=O)C2 C=CC(C)(C)C(=O)NCC1=NN=C2N1CCN(C(=O)C(C)(C)C(=O)NC)C2 CC(C)=C(C)C(=O)N1CC[C@H1](CNC(=O)C2=CN=C(C3=NC=CC=N3)S2)[C@H1](C)C1 CN1C=CC2=C(CN3CC(C4CCN(C(=O)C(N)=O)CC4)C3)C=CC=C21 C=CCCOCCCCC(=O)N[C@H1]1CC[C@@H1](N(C)C(=O)C2=CC(C)=CN=C2C)C1 CN(C[C@@H1](O)CNC(=O)C=CC(=O)NC1=CC=C(F)C=C1)C(=O)C2=COC(Cl)=N2 CO[C@@H1]1COCC[C@H1]1CN2N=NN=C2N3CCC[C@H1]3CN4CCCCC4 CC1=CN=CC(C(=O)N[C@H1](CNC(=O)CCN2CCC2)C3=CC=CC=C3F)=C1C CC(C)(C)OC(=O)N1C[C@H1](C(=O)N[C@@H1]2CCN(C3=CC=CC=C3Cl)C2)C4(CC4)C1 COC(=O)[C@@H1]1CC(F)(F)C[C@H1]1C(=O)N2CC(NC(=O)[C@H1]3[C@@H1](C)[C@H1]3C)C2 N#CC1=CN=CC(C(=O)N2CC3(CC[C@@H1](CNC(=O)C4=CN=C(C5CC5)[NH1]4)O3)C2)=C1 CN(C(=O)C1=CSC=C1Br)[C@H1]2CCCN(C(=O)[C@H1]3C[C@@](C)(O)C3)C2 COCCC[C@@H1](C)C(=O)NC[C@H1]1C[C@H1](NC(=O)CCC2=CC=CC(O)=N2)C[C@H1]1O CC[C@@H1](CC(=O)NCC[C@H1]1C[C@@H1](NC(=O)CC=2C=CN(C(F)F)N=2)C1)C(C)(C)C CN(C[C@@H1](O)C1=CC=C(O)C=C1)C(=O)CNS(=O)(=O)C2=CC=C(Cl)S2 CC1=CC(Cl)=CC=C1C(=O)N[C@H1](C)C2(CNC(=O)C=CC3=NC=C[NH1]3)CC2 CCC=1N=C(C)SC=1C(=O)N[C@H1]2C[C@@H1](C)CN(C(=O)C3=CC=C4OC=NC4=C3)C2 CCCCCCCCOCC(=O)NCC1(O)CN(C(=O)CC(F)(F)C(F)F)C1 C#CC=1C=NN(CC(=O)NC[C@@H1](C(=O)N(CC)[C@@H1](C)C(=O)NC)C(C)C)C=1 CC1(C(=O)N2[C@H1]3CC[C@H1]2CN(C(=O)C#CC4CCOCC4)C3)CC=CC1 C[C@H1]1C[C@@H1]1C(=O)N[C@H1]2C[C@H1](NC(=O)[C@@H1](C)NC(=O)[C@@H1]3CCC(=O)N3)C2 CCS[C@@H1]1CCC[C@@H1](N[C@@](C)(COCCOC)C2=NN=NN2C3CCCCCC3)C1 CC1(CC(=O)NCC2(NC(=O)C=CC3=CN=CC=N3)CCC2)CC(F)(F)C1 C=CC(=O)N1[C@H1]2CC[C@H1]1CC(C[C@@H1](C)NC(=O)C3=CC=C(C)C(OCC)=C3)C2 O=C(C=1C=C2N=CC=CN2N=1)N3CCS[C@H1](C(=O)N4[C@H1]5COC[C@H1]4C5)C3 [N-1]=[N+1]=NC[C@H1](NC(=O)[C@@H1]1CC(=O)CCO1)C(=O)NCC2=CC=CS2 C=CCN1C=C(C(=O)N2CCCN(C(=O)C=3N=CSC=3C(C)C)CC2)C=N1 CC/C(C)=C/C(=O)N1C[C@@H1](F)C[C@H1]1CN(C)C(=O)C2(C3=CC=C(C#N)C=C3)CC2 CCCSCC(=O)NC[C@H1]1C2=CC=CC=C2CCN1C(=O)[C@@H1](C)CC CC(C)C(C)(C)[C@H1](NC1=CC=C(CN(C)C)C=C1)C2=NN=NN2C[C@H1]3CCOC3 CCN1N=C(C(=O)N[C@H1](C)[C@@H1]2CCCN2C(=O)CC=3SC(S)=NC=3C)C=CC1=O CO[C@H1]1CC[C@@H1](C(=O)N2CC[C@@]3(CO)CN(C(=O)C(F)(F)C(F)F)C[C@H1]3C2)CC1 CC[C@H1](CN(C)C(=O)C(C)(C)CC(F)F)NC(=O)C(C)(C)C1=CC=CC=C1C COCCN(CCNC(=O)C1=C(C)OC(C)=C1C)C(=O)C[C@@H1](C)SC CC(C)OCC(=O)N1CCCN(C(=O)C[C@H1](O)C(C)(C)C)CCC1 CCC1=C(C(=O)N(CCNC(=O)C2=CSC=C2C(N)=O)C3CCCC3)CCCO1 C#CCSCC(=O)N[C@@H1]1CCC[C@@H1](NC(=O)C2=CC=C3C=C(C)C=CC3=N2)C1 CCN1N=C(C(=O)NC[C@H1](NC(=O)C2=CC=NC3=CC=NN23)C(C)C)CCC1=O CCC(C)=C(C)C(=O)NC[C@@H1](CNC(=O)C1=CC=NC2=CC=C(F)C=C12)OC CN(C(=O)[C@@]1(C)CCOC1)C2(CC(=O)N3CC4(COC(=O)C4)C3)CC2 C=CCC1=CC=CC=C1C(=O)N2C[C@H1](NC(=O)CCN(C)CC)C[C@@H1]2C CC(C)(C)SCC(=O)N[C@H1]1CC[C@H1]1NC(=O)C2=CC=C(C3=CC=C(Cl)C=C3)C=N2 CCC1=CC=C(C(=O)N[C@@H1](C)C(C)(C)NC(=O)[C@@H1]2CCC3(CCC3)O2)C=C1Cl O=C(CCN(CCCO)C(=O)CC1=CC=C[NH1]1)NC2(C=3N=C[NH1]N=3)CC2 C[C@](O)(C(=O)N1CCC[C@@H1](CN[C@H1]2C[C@@H1]3CCCCN3C2)C1)C4=CC=C(F)C=C4 O=C1NC[C@@]2(CCCN(C3=NC(=NC[C@@H1]4C=CCC4)[NH1]C=5C=C[NH1]C3=5)C2)O1 CC1=NO[C@H1](CC(=O)N2CC=C(CCNC(=O)C3=C(F)C=CC=C3F)CC2)C1 CN1N=C(Br)C=C1C(=O)N[C@H1]2C[C@H1](NC(=O)[C@H1]3CCCS3(=O)=O)C2 C=C(Cl)CNC(=NCCC(C)C)NC[C@@H1](C(=O)N1CCOCC1)C2=CC=CC=C2 CN(CCO)NC(=O)N[C@@H1]1CCCC2=N[NH1]C=C21 COC[C@@](C)(O)C(=O)NC[C@@H1]1CCCN(C(=O)C2=C(C)C=C(C)C=C2C)CC1 CC1=C(C(=O)N2CC[C@@H1](CCC(=O)NCC3=CC=C(C#N)S3)C2)[NH1]C=CC1=O CSC(C)(C)C(=O)NCC(=O)N1CCN(C(=O)C=2SC(C)=CC=2Br)CC1 CC1=CC=CC([C@@H1](O)C(=O)NCCN2C=CC(C3(C(F)(F)F)CC3)=C2)=C1 CN1C=C(CC(=O)NC[C@@H1]2CCCCN(C(=O)C3=CC=CC(CC#N)=C3)C2)C=N1 CO[C@H1]1C[C@@H1](CNC(=O)C2=NC=C(C)C=C2C)N(C(=O)[C@@H1]3C[C@H1](C)CC(=O)N3)C1 C=CCCCCC(=O)N[C@H1]1CCC[C@@H1](NC(=O)C=CC=2SC=NC=2C)CC1 CC1=CC=C(C(=O)NC[C@@H1](C)NC(=O)[C@@H1](C)OC2=CC=CC(Cl)=C2)C(O)=C1 CN(C[C@H1]1CCCN1C(=O)C2(C3=CC=CS3)CCOCC2)C(=O)C=CI CC1(C)CN(C(=O)CN2N=CN=N2)C[C@H1]1NC(=O)CC[C@@H1]3CC3(F)F C=C(F)C1(CC(=O)N[C@@H1](C)[C@H1](C)N2C=NC=N2)CN(C(=O)OC(C)(C)C)C1 CC1=CC(CC(=O)N[C@@H1]2CN(C(=O)C3=C[NH1]N=C3C(C)(C)C)C[C@H1]2C)=CC=C1O CN(CCCNC(=O)C1(F)CCC1)C(=O)C=2N=NN(C(C)(C)C)N=2 COC(C)(C)CCC(=O)N1[C@H1]2CC=C(C(=O)N[C@@]3(CO)C[C@H1]4CC[C@H1]3C4)[C@H1]1CC2 O=C(NC=C(C1=CC=C(F)C=C1)C(Cl)=NC2=CC=CC=C2)C[C@H1]3CC34CC4 C=CCC1(C(=O)N[C@H1](C)C2(O)CCCCC2)CN(C(=O)[C@H1]3OCCC3(C)C)C1 CC[C@H1](CN(C)C(=O)CCOC)NC(=O)[C@@H1](CCOC)OC CP(C)(=O)C1=CC=C(C(=O)N2CC[C@@H1](CNC(=O)CNC(=O)NC3CC3)C2)N=C1 CC=CC=CC(=O)NC[C@@H1]1CCN(C(=O)[C@@H1]2C[C@H1](OC)[C@H1](OC)C2)C1(C)C CC(C)(C)OC(=O)N[C@@H1]1C[C@@H1](NC(=O)[C@]2(C)CC(C(F)(F)F)=NO2)C1(C)C C#C[C@H1](NC(=O)[C@H1]1CCCCCN1C(=O)C2=CC(F)=C[NH1]2)C3CCCCC3 CN(C)[C@@H1]1CCC[C@H1]1NC(=O)NCC2(CC3=CC=C(Br)C=C3)CC2 O=C(N[C@H1]1C[C@@H1]2C[C@H1]1N(C(=O)C(F)(F)C3=NC=CC=C3F)C2)C4CCC4 COC1=CC(C(=O)NC2CC(NC(=O)C3=CC=NN3CCN(C)C)C2)=C(F)C=N1 C=C(C)[C@H1]1OCC[C@H1]1C(=O)NCC(=O)NCC(=O)NC(C)(C)[C@@H1](O)C(F)F CC1=NN=C(CC(=O)NCC2CN(C(=O)[C@@]3(Br)CC3(C)C)C2)O1 CCCN(C)CC(=O)NC[C@@H1]1C[C@@H1](NC(=O)[C@@H1]2CCN(C)[C@H1](C)C2)CCO1 CO[C@]1(C(=O)N2CC[C@@H1](NC(=O)CC3=NOC=C3C)[C@H1](O)C2)CCS(=O)(=O)C1 CCS[C@H1](C(=O)NCCCCCC(=O)N(C)[C@H1]1CCC(C)(C)C1)C(C)C CCC1(NC(=O)[C@@H1]2C[C@@H1](O)CN2C(C)=O)CN(C(=O)[C@@H1](C)CC(C)C)C1 CC[C@@H1](C)OCC(=O)N1CC(F)(F)C[C@@H1]1CNC(=O)C=C2CCOCC2 CCC1=NOC(COCC(=O)NCCN(CC)C(=O)[C@H1](O)CSC)=N1 C[C@H1](C[C@@H1]1CCCO1)C(=O)NC[C@H1]2CCN2C(=O)C=3C=NC4=NC=NN4C=3 COC1=CC(C)=CC=C1C(=O)N2CCC[C@@H1]2[C@H1]3CCN(C(=O)[C@@H1]4C=C(C)CS4)C3 C[C@H1]1CC(N(C)C(=O)C(C)(C)CCNC(=O)C=C2CCOCC2)C[C@H1](C)C1 O=CN1CCC[C@H1]1C(=O)N2C[C@H1](F)[C@H1](NC(=O)C3=CC=CC(Cl)=C3Br)C2 O=C(NOCC=CC1=CC=CC=C1)[C@H1]2CCN(C(=O)[C@@H1]3C[C@@H1]3F)O2 O=C(NC1=CC=CC=C1C2=NC(C3=CC=CC=C3)=NO2)C(=O)NCC[C@@H1]4CC4(Cl)Cl COC1=CC=C(C2=CSC(NCC3=CC=C(O)C=C3)=C2C(=O)NCC(C)(C)O)S1 CC1(C)[C@H1](NC(=O)C=2C=C[NH1]C(=N)N=2)[C@@H1]3CCCN(C(=O)CS(=O)(=O)CCO)[C@H1]31 CCOCCCCC(=O)N[C@H1]1CO[C@]2(CCN(C(=O)CN(C)C(N)=O)C2)C1 COC1=CC(C)=C(C(=O)NC[C@H1]2CCN(C(=O)[C@H1](C)CN(C)C)C[C@@H1]2C)C=N1 COCCC=1C=C(NS(=O)(=O)C[C@@H1]2C[C@@H1]3O[C@H1]2[C@H1]4C[C@@H1]34)N(C)N=1 COC1=CC=C(C)C(OC)=C1C(=O)N2CC(CNC(=O)C=3N=CSC=3C)C2 CCN(C(=O)CCC1=CON=C1C)[C@@H1]2CCN(C(=O)CC[C@@H1]3C[C@H1]3C)C2 C=C(CCNC(=O)[C@H1]1CCCCO1)CNC(=O)C2(C3=CC=C(C)C=C3OC)CC2 C=C[C@@H1]1CCN1C(=O)[C@]2(C)CCCN(C(=O)[C@@H1]3C[C@@H1]4CC[C@@H1]4C3)C2 CC(C)CCCCCC(=O)N1C[C@@H1]2CC[C@H1](NC(=O)[C@H1](C)SC(F)(F)F)C[C@H1]2C1 C[C@@H1](NC(=O)CC1=CCOCC1)[C@@H1]2CCCN(C(=O)C3=CN=CC(O)=C3)C2 C[C@@H1]1C[C@@H1](C(=O)N2CCC3(CN(C(=O)C4=CC=CC(N5C=NN=N5)=C4)C3)C2)CO1 CCC[C@H1]1CCCN(C(=O)C=2C=C(CNC(=O)C3=NO[C@@H1](C)C3)ON=2)CC1 CC[C@@H1](CNC(=O)C1(CO)CCCC1)NC(=O)C2=CC=CC(F)=C2 CN(CCC1=CC=CC=C1)CC2CN(CCOC3=CC=CC(C(=O)O)=C3)C2 CN(CC(C)(C)C)C(=O)C[C@]12CC[C@@H1]1CN(C(=O)C3=CC=C4[NH1]N=C(Cl)C4=C3)C2 CCN1N=NC=C1C(=O)N2[C@H1](C)C[C@@H1]2C(=O)N3CC4=CC=NN4C[C@@H1]3C O=C(N[C@H1]1[C@@H1]2CC[C@@H1](C2)[C@H1]1C(=O)NOCCCC(F)(F)F)C=3C=CSC=3 CNS(=O)(=O)[C@@H1]1CCCN(C(=O)C(=O)NCC2CN(C(C)=O)C2)C1 C=C[C@H1](CC)CC(=O)NCCOC1CCN(C(=O)CC2=C(C)C=CC=C2C)CC1 O=C(C#C[C@@H1]1CCOC1)NCC[C@@H1]2CSCCN2C(=O)COC3CCC3 CC1(C)OC(=O)N[C@H1]1C(=O)NCCN(C(=O)C2=CC(Cl)=C(F)C=C2F)C3CC3 O=C(CC=1C=COC=1)N[C@@H1]2CN(C(=O)[C@H1](O)CC(F)(F)F)C[C@H1]2C3CC3 C=CC1(C(=O)N2CC[C@@H1](OCC(=O)N3CC([S@@](C)(=N)=O)C3)C2)CCOCC1 CN1C=CN=C1CC(=O)N2CC=C(CNC(=O)C=3C=NN(C4CCCC4)C=3)CC2 C=CCC1(NC(=O)C2=CC(Br)=C(C)O2)CCN(C(=O)[C@H1](O)C=C)CC1 CC1(C)CN(C(=O)C=CC2=CN=CS2)[C@@H1](CNC(=O)CN3CCS(=O)CC3)CO1 C=CCCOCC(=O)N(CCNC(=O)[C@@H1](NC=O)C(C)C)C1CC1 COC1=CC(Cl)=C(Cl)C=C1CN2CC3(C[C@@H1]3C(=O)NCC4=CC=CC=C4Cl)C2 CCN(CCNC(=O)C1=COC(O)=N1)C(=O)C2=CC=C(C3=CCCC3)C=C2 O=C(N[C@@H1]1CC[C@H1]2CCN(C(=O)CC3CC3)[C@H1]21)[C@H1]4CCN(C5=CC=CC=C5)C4=O CCCN(C(C)C)[C@H1](C(=O)NCC(C)C)C1=CC(CC)=NN1C C[C@@]1(C(=O)NC2=CC=CN3N=CN=C23)CCCN(CC4=CC=C(Br)C=C4F)C1 CC1(C(=O)N2CCC[C@@]3(NC(=O)C=4C=C5N(N=4)C[C@@H1](F)C5)C[C@@H1]3C2)CC=CC1 C[C@@]1(CNC(=O)C2(C(F)(F)F)CC2)CCN(C(=O)[C@H1](O)C3CCCC3)C1 CN1C=C(C(=O)N[C@@H1](C(=O)N2C[C@H1]3CCC[C@H1]3C2)C4(O)CCC4)C=CC1=O CC1=CON=C1C(=O)NCC2(F)CN(C(=O)C[C@@H1]3COCC4=CC=CC=C43)C2 CCC(F)(F)CC(=O)N1CCC[C@H1](C)[C@@H1]1CCNC(=O)C2=CC=C([N+1](=O)[O-1])[NH1]2 O=C(N[C@H1]1[C@@H1]2CN(C(=O)CCC3=CC=C(F)C=C3Br)C[C@@H1]21)C4=CN=CO4 CC1=CC=C2C(=C1)C[C@@H1](C(=O)N3CCCO[C@H1](CNC(=O)C4=CC=C[NH1]4)C3)O2 CC(=O)NCCCC(=O)NC[C@]1(CNC(=O)[C@@](C)(O)CC(C)C)CC12CCC2 CO[C@@H1](CC(C)C)C(=O)N[C@H1]1CCC[C@@H1]1NC(=O)C2=NC=CN3N=C(C)C=C23 C[C@H1](F)CC(=O)N[C@H1]1C[C@H1](CC(=O)N2CCC[C@H1]3OCC[C@H1]32)C1 C#CC1=CC=C(C(=O)N2CC3=NC=CN3C[C@@H1](NC(=O)C[C@@H1](C)CF)C2)C(F)=C1 CCC1CC(CC(=O)N[C@H1]2C[C@@H1](CNC(=O)[C@]34CC[C@@H1](OC)[C@H1]3C4)C2)C1 CC[C@H1](OC1CCCCC1)C(=O)N2CC(NC(=O)C3=CN(CCC(C)C)N=N3)C2 COCC(COC)C(=O)N1CCN(C(=O)C=2N=C(C)SC=2C)[C@@H1](C3CCC3)C1 N=C1C=C(C(=O)N2C[C@H1]3CC[C@@H1](C2)[C@@H1](NC(=O)CC4CC5(CCC5)C4)C3)[NH1][NH1]1 COC=C1C=C(OC)C(C(=O)N[C@@H1]2CCN(CCCNC(=O)C3(C)CC3)C[C@@H1]2C)=C1 CC1=C(CNS(=O)(=O)CCO[C@H1]2CCOC2)C=NN1CC(C)C CCS(=O)(=O)C1=CC=C(Cl)C=C1C(=O)O[C@@H1](C)C2=CC=C(Cl)C=C2 COC(=O)N[C@H1](CC(C)C)C(=O)N1[C@H1](C)[C@H1]2C[C@@H1]1[C@H1]2NC(=O)[C@@H1]3CCC(=O)NC3 CN1N=CC(C(=O)N[C@H1]2C[C@@H1]3CN(C(=O)[C@]4(C)CCCCO4)C[C@@H1]3C2)=C1C5CC5 CN(CC1=CCCOC1)S(=O)(=O)C2=CC=C(N[C@@H1]3CCCC4=N[NH1]C=C43)C(Cl)=C2 COC(=O)C1=C[NH1]N=C1C(=O)N(C)CCCNC(=O)[C@@H1](C)N2C(C)=CC=C2C C[C@@H1]1CC[C@@H1]1C(=O)N2CC[C@H1](NC(=O)COCC3CCC3)[C@H1]2C(C)(C)C CNC(=O)[C@H1](NC(=O)NC1=CC=CC(COC2=CC=C(Br)C=C2)=C1)C(C)C CC1=NC=C(C(=O)NC2CC([C@@H1]3CCN(C(=O)C4=NC=C[NH1]C4=O)C3)C2)O1 CCC(C)(C)[C@H1](O)C(=O)NC[C@H1]1CCN1C(=O)C=2C=NC3=C[NH1]N=C3C=2 CC[C@@H1](C)CC[C@@H1](O)CC(=O)NCC1(C(N)=O)CN(C(=O)C2=NN=CN2C)C1 O=C(N[C@@H1]1CCCN(C(=O)[C@H1](O)C2CCC2)CC1)C3=CC(C4CCC4)=NO3 O=C([C@@H1]1[C@@H1]2C[C@H1]2[C@H1]3C[C@H1]31)N4CCCN(CC5=CSC(Br)=C5)CC4 O=C(CC1(O)CC1)N2CCN([C@H1]3CCN(C(=O)[C@@H1]4C[C@H1]5[C@@H1](C4)C5(F)F)C3)CC2 CN(CCOCCN)C(=O)C(=O)NC1=CC=C(OC2=CC=C(F)C=C2Cl)N=C1 COC(C)(C)CNC(=O)[C@@H1]1C[C@@H1](C)CN(C(=O)[C@H1](F)C2=CC=C(C)C=C2)C1 C[C@@H1](CCNC(=O)CN1C=NC(C(N)=O)=N1)CCNC(=O)C2=CC=CC(=O)O2 C[C@H1](O)C(=O)NC[C@@H1]1CC2(CCC2)CN1C(=O)[C@H1]3CC[C@]4(CC3)CC4(F)F O=C(CN1C=CC(=NCC2=CC=C(CO)C=C2)N=C1O)NC3=CC(Cl)=CC(Br)=C3 CCOC(=O)CCNC(=O)[C@H1](C[C@H1]1COC(C)(C)O1)N2CCN(C(C)=O)CC2 C=CC[C@@H1](CNC(=O)[C@H1](C)OC1=CC=CC=C1F)NC(=O)C2=CC(C)=NC=C2C CO[C@H1]1C[C@H1](NC(=O)CS(=O)(=O)CCO)CN(C(=O)C2=C(C)C=C(Cl)C=C2N)C1 CS(=O)(=O)C1(C(=O)N[C@H1]2C[C@@H1](CO)N(C(=O)CN3CCC(O)CC3)C2)CC1 C[C@@H1]1C[C@@H1](CN=C2[NH1]C(N3[C@H1]4CC[C@H1]3CN(CC(F)F)C4)=NC(=N)[NH1]2)CCS1 CC(C)N1C=C(C(=O)N[C@@H1]2CCCC[C@]23CCN(C(=O)C#CC4(C)CC4)C3)N=N1 CCCC=1ON=C(C)C=1C(=O)NC[C@@H1](NC(=O)[C@H1]2CCCC=3N=N[NH1]C=32)C(C)C CC=1[NH1]N=C(C(=O)NC[C@@H1]2CCCC3(CN(C(=O)[C@@H1]4CCC4(F)F)C3)O2)C=1C CCC=1C=C(C(=O)N2CCC([C@H1](CO)NC(=O)C=3N=NSC=3C)CC2)N(C)N=1 C=CC1(O)CN(C(=O)[C@@H1](NC(=O)C2=C(C)OCCS2)C3CCCCC3)C1 C=C[C@H1]1C[C@H1]1C(=O)N2CCN(C(=O)C=3SC=CC=3NS(C)(=O)=O)C[C@@H1]2C4CC4 C=C[C@H1](CC)CC(=O)N1CC(C2CCN(C(=O)C=3N=CN(C)N=3)CC2)C1 O=C(NC[C@@H1]1CCN1C(=O)[C@@H1](C2=CC=CC(Cl)=C2)N3C=CC=N3)C4=CC(F)=N[NH1]4 CN(CCN(C)C(=O)C1=C(F)C=CC(O)=C1F)C(=O)C2=NO[C@@]3(CCOC3)C2 CCCC=1N=COC=1C(=O)NC[C@H1]2CN(C(=O)[C@H1]3C[C@@H1](O)C3)C4(CCC4)C2 CC(=O)N[C@@H1](C(=O)NCC1CN(C(=O)C2=CC(F)=C(O)C(Br)=C2)C1)C(C)C CCN(CCNC(=O)CS(=O)(=O)N(CC)CC)C(=O)CC(C)(C)CC(=O)OC CCN(C(=O)C1=CC2=NC=C(Br)C=C2O1)[C@H1]3CCCN(C(=O)CCC(C)C)C3 C[C@@H1]1CCC2=N[NH1]C=C2[C@H1]1C(=O)NC[C@H1](CNC(=O)[C@H1]3CCCO3)C(F)(F)F C[C@@]1(C(=O)NCC2=CC=C3C(=C2)OCCO3)CCN4C=CN=C41 COC1=NC=CC=C1CC(=O)NC[C@@H1](C)CN(C)C(=O)C2=CC=NN2C CC(C)(C(=O)NC[C@@H1]1CCC[C@H1](NC(=O)CC=2C=CON=2)C1)[C@H1]3CCCCO3 CN(C)C1=CC=C(C(=O)N2CC(CNC(=O)CSC3CC3)C2)C=N1 CCCN(C(=O)C1=CC=C([N+1](=O)[O-1])C=C1)[C@H1]2CCN(C3=CC(F)=NC=N3)C2 O=C(N[C@@H1]1C=CCN(C(=O)C2([C@H1](O)C(F)(F)F)CCC2)C1)C3=CC=C4C(=C3)CC4 CN1CCO[C@@H1](C(=O)N(CCCNC(=O)C=2SC(CO)=NC=2C)C3CC3)C1=O CCCC(=O)NCC(=O)N1CC[C@H1]2[C@@H1](C1)NC(=O)CN2C(=O)CCC3=NC=CS3 C[C@H1](NC(=O)CC=1SC(O)=NC=1O)[C@@H1](CO)NC(=O)[C@H1]2CCCC2(C)C CN(C)[C@H1]1C[C@H1](C(=O)N2CC[C@H1](CNC(=O)[C@H1](NS(C)(=O)=O)C(C)(C)C)C2)C1 CCCC(=O)NC[C@H1]1CCC[C@@H1](CNC(=O)CN(C)C2=NC=NC=3[NH1]C=NC2=3)C1 COCCSCC(=O)N1CC2=C(C1)CN(C(=O)[C@@H1](C)SC3=NN=NN3C4CC4)C2 NC(=O)NCC(=O)NCC1(NC(=O)C2(C3CC3)CC2)CCOCC1 CC1=CC(C(=O)N[C@H1]2CN(CC3=C[NH1]C4=CC=C(F)C=C34)C[C@@H1]2C#N)=CC=N1 C=CCNC(=O)[C@H1](C)N(C)C[C@H1](O)CN(C)C(=O)C=1SC(COC)=NC=1C CC1=NC(C#N)=CC(N(C)CCCNC(=O)CSCC(F)(F)F)=N1 O=C(N[C@H1](CO)CCCCNC(=O)[C@H1](F)N1C=CC=N1)C2=CC=C(Br)O2 CC=1C(C(=O)N2CCC(C3CN(C(=O)[C@H1]4C[C@H1]4Cl)C3)CC2)=NN5C=1CCCC5 CCOC=CC(=O)N1CC[C@@](C)(CNC(=O)C=2N=C(O)SC=2C)C1 CCCC[C@H1](O)C(=O)N[C@@H1](C)CCN(C)C(=O)C=1C=NN(CCN2CCCCC2)C=1 CCOC=1C=C(C(=O)N(CCCN(C)C)CCNC(=O)[C@H1]2CC(C)=NO2)ON=1 CCN(CCC(N)=O)C(=O)[C@@H1]1CC=CCN1C(=O)[C@@H1]2CCOCC2(C)C CN1C[C@@H1](O)CC[C@H1]1C(=O)NCCN(C(=O)CC2=CC=C(O)C(F)=C2)C3CC3 N#CC1=CC=C(C(=O)N[C@H1]2CN(C(=O)C3(C4=CC=NO4)CC3)CC25CC5)S1 CC1=CN=CC(C(=O)N(C)CC[C@@H1](C)NC(=O)C=2C=NN3C=CSC=23)=N1 CO[C@@H1]1C[C@H1](CNC(=O)N2CCC[C@H1]2C3CCC3)OC1 CC(C)(C)[C@H1](CNC(=O)CCO[C@@H1]1CCOC1)NC(=O)C(=O)C2=CC=CC=C2 COCC=CC(=O)N1CC[C@H1]1CNC(=O)C2=CC=C3C=CC=CC3=C2C CN1N=NC(/C=C/C(=O)N[C@@]23C[C@@H1]2CN(C(=O)C4=CC(Cl)=CC=C4N)C3)=N1 CC1=CC(Cl)=C(C(=O)N2CCN(C(=O)C[C@@H1]3CC[C@H1](O)C3)[C@H1](CCO)C2)C=C1N C#CC1=CC=C(C(=O)NC[C@H1]2CC[C@@H1](C)N(C(=O)C3=NC=CN3CC)C2)N=C1 CCC[C@H1](CC)CCC(=O)N1C[C@@H1]2C[C@@H1]2[C@@H1](NC(=O)C3=CN=C(Br)S3)C1 COC(=O)C(C)(C)CCCC(=O)N1CC(CO)(NC(=O)[C@H1](F)CC(C)C)C1 CC(=CC=1C=N[NH1]C=1)C(=O)N(C)CC2(CNC(=O)C3CC4(CC(CO)C4)C3)CC2 C=CC[C@H1](OC)C(=O)NC[C@@H1](CC)N(C)C(=O)CC1=CC=C(CO)C=C1 O=C(CN1CC(=O)NC1=O)NCC[C@H1]2CN(C(=O)C[C@@H1]3CCOC3)CCO2 O=C(NC[C@@H1]1C[C@H1](F)CN1C(=O)CC2=C(F)C=CC=C2Cl)C3=CC=C(Cl)N=C3O CCN1N=NN=C1[C@@H1](NCC2=C(C)CCOC2)C3=COC4=CC=C(Br)C=C4C3=O CC1(C)COC[C@@H1]1C(=O)N2CC[C@](CF)(NC(=O)CC3=CC=C4C(=C3)CCC4)C2 CC1=NC=CC(C(=O)NCC[C@H1](C)N(C)C(=O)CCC2=CC=C(O)C(O)=C2)=N1 CN1C[C@H1](C(=O)NCCC(C)(C)NC(=O)C[C@@]2(C)CC2(F)F)OCCC1=O C[C@H1]1CCCC[C@@H1]1CC(=O)NCCOCCN(C)CC=C(Cl)Cl CCC1(C#CC(=O)N2CCCC[C@H1]2CCNC(=O)C=3N=C(C)OC=3OC)CC1 COC1=CC=C(C)C=C1C2=CN(CCN(C)C(=O)[C@H1]3CCC4(CCCC4)C3)N=N2 N#CCC(=O)N1CCN(C(=O)C2(F)CCC2)C[C@H1]1CF CN(C)C[C@@H1]1C=CCN1C(=O)[C@H1]2CNC(=O)CN2C(=O)CSC3CC3 O=C(CCC1=CN=CO1)NCC[C@@H1](O)CNC(=O)C2=CN=C3N2CCS3 CC(=O)NC1=CC=C(Cl)C(NC(=O)[C@@H1]2C[C@H1](O)CN2C(=O)C[C@@H1]3CCCCO3)=C1 CCC[C@@H1]1CCC[C@@H1]1C(=O)N[C@@H1]2C[C@H1]3CN(C(=O)CC4(OCC)CC4)C[C@H1]32 CC1=NC=CC(C(=O)NCC#CCNC(=O)CN2CCN(S(C)(=O)=O)CC2)=C1C C[C@@H1](NC(=O)C=1C=NN(C2CC2)C=1)[C@@H1]3CCN(C(=O)CC4=CSC(Br)=C4)C3 CO[C@H1](CNC(=O)C=1C(C)=NN(C)C=1C)CC(=O)N2CC3(CC(F)C3)C2 C=CCO[C@@H1](C)C(=O)N1C[C@@H1]2CC[C@H1](C1)[C@H1](NC(=O)C[C@@H1](C)SC)C2 CO[C@H1](CNC(=O)[C@@H1](F)OC(F)(F)F)CC(=O)NCCC1=NC=C(C)O1 C=C/C=C/CCN=C1N=C(N2CCO[C@@H1](C(=C)C)C2)C=C(C)[NH1]1 C#CCCCCC(=O)NCCCNC(=O)[C@H1]1CSCN1C(=O)OC(C)(C)C CCOC[C@H1](C)C(=O)NC[C@@H1]1CC[C@H1]1NC(=O)C2=CC=CC(NS(=O)(=O)CC)=C2 COC=1SC=CC=1C(=O)N[C@@H1]2CCCCN(C(=O)C3=CC=C4N=C(S)[NH1]C4=C3)C2 C=CC[C@@]1(NC(=O)[C@@H1]2C(F)(F)C23CCC3)CCN(C(=O)C4=C[NH1]C=CC4=O)C1 C#CCCCCC(=O)N1C[C@@H1]2C[C@]2(NC(=O)C=3[NH1]C4=CC(Cl)=CC(Cl)=C4C=3C)C1 O=C(NC[C@@H1]1CCC12CCN(C(=O)C=3C=C(CO)[NH1]N=3)CC2)C4=CC=NC(O)=C4 CC(C)[C@H1](O)CC(=O)NC[C@@H1]1C[C@@H1]2C[C@@H1]2N1C(=O)C3=COC4=C(F)C=C(F)C=C34 CC(=O)N1CC(C(=O)NCC2=CC=C(C(=O)NCC3(O)CC3)S2)C1 CC1=CC=CC2=C(C(=O)N[C@@H1]3CCC[C@H1]3NC(=O)C4=NC=CC(Cl)=C4C)C=NN12 C[C@@H1]1C[C@]2(C(=O)N[C@@H1]3CN(C(=O)CC4=CSC5=NCCN45)C[C@@H1]3O)C[C@H1]12 O=C(N[C@H1]1C[C@H1]1NC(=O)C=2C=CC(=O)OC=2)C3=CN=CC(OCC(F)F)=C3 O=C(C=CC1=NC=C[NH1]1)NC[C@@]23CCC[C@@H1]2CCN3C(=O)CC4=CC=CC=C4F CN(CC=1SC(Cl)=NC=1C(N)=O)CC2=CC3=CC=CC=C3O2 CC(C)C(=O)NC1=NC(CC(=O)NCC=2OC=CC=2Br)=CS1 COC1(CN(C)C(=O)C2=CCN(C(=O)[C@H1](C)O)CC2)CCCC1 CC1=CC(C(=O)NC2[C@H1]3COC[C@H1]2CN(C(=O)[C@H1](C)C#N)C3)=CC([N+1](=O)[O-1])=C1Cl CC=1C=NN([C@H1]2CCCN(C(=O)C3=CN=C4C=CC(Br)=CN4C3=O)C2)C=1 C[C@H1](O)CN(CCNC(=O)C=CC1=CC=CS1)C(=O)C2=CC=NN2CC3CCC3 CS[C@H1]1CCC[C@@H1]1N(C)C(=O)C2=CN3C(=N2)CCCC3 CCC1=CC=NC=C1NC(=O)CC(C)(C)CNC(=O)C[C@H1](O)CC CC(C)NC(=O)NC(=O)[C@H1](C)N1CC[C@H1]2CC[C@@H1](C1)S2 CC1=NSC=C1C(=O)N(CCC(=O)NC[C@]2(C)CC2(C)C)C3CC3 CC1=NC(CNS(=O)(=O)C2=CC=C(NCCSCC3=CC=C(C)C=C3)N=C2)=CS1 CCC[C@H1](OC)C(=O)NCC1(OC)CN(C(=O)[C@@H1]2C[C@H1]2C3CCOCC3)C1 COC1=CON=C1C(=O)N[C@@H1]2CCCC[C@@H1]2CNC(=O)C3=CC(S(C)(=O)=O)=CO3 COCC(=O)N(C)CC(=O)N[C@H1](CC(=O)N1CCN(C(=O)CO)CC1)C(C)C C=CCC[C@H1](NC(=O)[C@@H1]1CC(=O)OC1(C)C)C(=O)N[C@H1](C)C2=CN=C(C)S2 CC1=C(N)C=NC=C1C(=O)N2CCC(N(C)C(=O)[C@@H1]3CC(C(C)C)=NO3)CC2 O=C(N[C@H1]1CC[C@H1](N=C2C=CN=C(C3CCC3)[NH1]2)C1)C4(CF)CC4 COC(=O)C[C@H1](C)CC(=O)N1CC[C@H1]([C@H1](C)NC(=O)[C@H1](C)[C@@H1]2CCC(=O)N2)C1 CC1(F)CCN(C(=O)[C@@H1]2CN(C(=O)C3=C[C@]4(CCOC4)C3)CC2(C)C)CC1 O=C(CCN1C=NC([N+1](=O)[O-1])=C1)N[C@H1](CNC(=O)C=2C=COC=2)C3CCCC3 CON(C[C@H1]1CCC[C@H1](C)C1)C(=O)C2CC3(CCC3)C2 CC1=NC=C(C(=O)N2CCCN(C(=O)C3=CC=CC(Br)=C3N)C[C@H1]2C(C)C)[NH1]1 COCC=CC(=O)N[C@]1(C)C[C@H1](NC(=O)CCC2=CC(C)=NC(C)=C2)C1 N=C1C=CC(C(=O)N2CC=C(CNC(=O)C3=CC=4N=C[NH1]C=4C=N3)CC2)=C(Cl)[NH1]1 CC[C@@H1](C)OCC(=O)N[C@H1]1CN(C2=NC=C(OC(C)C)C=N2)CC3(CC3)C1 CC1=NN=C2C(C(=O)NC[C@@H1](CO)CNC(=O)[C@H1]3CCC(C)(C)O3)=CC=CN12 CC=1[NH1]N=C(Cl)C=1C(=O)N(C)CCN(C(=O)C2=CON=C2[C@@H1]3CCCO3)C(C)C CC[C@@H1](O)CCNC(=O)C(=O)NC1=CC=C2C=NC=CC2=C1 CCC[C@](C)(O)CC(=O)N1CC=C[C@@H1](C(=O)N2CC(C)(C(N)=O)C2)C1 CC1=NOC(C)=C1CCNC(=O)CCN(C)C(=O)CC[C@H1]2C[C@@H1](C)CS2 CCC1=NSC(CNC(=O)CCN(C)C(=O)C2=CSN=C2C)=N1 CC1=CC=C(C(=O)NCCNC(=O)C2=CC=CC3=C2CCC(=O)N3)C=C1O C#CCCCNC(=O)[C@@H1]1[C@H1]2[C@H1]3C[C@H1]1[C@H1](NC(=O)C4=CN=C5C=CC=CN45)[C@@H1]23 C[C@@H1](CNC(=O)CCC(F)F)C1CCN(C(=O)C=CC2CCOCC2)CC1 C[C@@H1](CCNC(=O)C1=CC=C(F)C=C1C#N)N(C)C(=O)C=2SC(CO)=NC=2 CC(C)N(CCN(C)C(=O)/C=C/C1=NC2=CC=CC=C2S1)C(=O)[C@@H1]3CNC(=O)N3 CC1=CN=CC(C(=O)NC2CC3(C2)CC(C(=O)N[C@H1](C)C4=CC=CS4)C3)=N1 CN1N=CC(C(=O)NC[C@@H1]2CC(C)(C)CN2C3=NC(C4CC4)=NC(=N)[NH1]3)=C1Cl COCCC(=O)NCCCN(C1=NC(Cl)=NC(C)=C1C#N)C2CC2 COC1=C([C@@H1](C(=O)NCC=2N=NN(C)N=2)N(C)CCS(N)(=O)=O)C=CN=C1F CC=C1C=C2N=CC(C(=O)N3C[C@H1](NC(=O)C4=CCC[C@H1]4C)CC35CCC5)=CC2=C1 CN1C=C(CNC(=O)[C@@H1]2C[C@H1]2[C@@H1](C)NC(=O)C3=CC=C(C(F)F)O3)C=N1 CO[C@H1](CNC(=O)COC1=CC=CC=C1[N+1](=O)[O-1])CNC(=O)CC2(O)CCCC2 CC1=CC(CCNC(=O)[C@H1]2C[C@]23CCN(C(=O)C=4C=CN(C)C=4)C3)=N[NH1]1 C[C@@H1]1CCC2=NC=C(C(=O)N[C@H1]3CC34CC(NC(=O)CCC(F)(F)F)C4)N2C1 CCCN1C[C@H1](C(=O)N[C@@]23CCC[C@H1]2N(C(=O)CSCCC#N)CCC3)CC1=O CC(C)COCC(=O)NCCC1(O)CN(C(=O)C=CCN2CCCC2)C1 CC1=CSN=C1C(=O)N[C@@H1](C)CCN(C)C(=O)C2(CO)CC2 CCOCCOCC(=O)N1CC[C@H1](C(=O)N(C)CC2=C[NH1]N=C2C)[C@@H1]1C CC=1C=C[NH1]C=1C(=O)N2C[C@H1]3[C@H1](CNC(=O)C4=CC(F)=C(F)C=C4Cl)C[C@H1]3C2 CCCCC1(C(=O)N[C@H1]2CCCCCN(C(=O)[C@@H1](O)C3CCCC3)C2C)CC1 CO[C@@H1](CCS(C)(=O)=O)C(=O)NC1=CC=C(CN)C(F)=C1 C[C@@]1(CC(=O)NC[C@@H1]2C[C@H1]2NC(=O)C3(C4=CC=CS4)CC3)CC1(F)F C#CCN1C=NN=C1C(=O)NC[C@H1](NC(=O)[C@@H1](C)COC(C)=O)C2=CC=CC=C2 CCOC(=O)C(F)(F)CN(C)C(=O)C1=NSC=C1Br CC1=CC=C(C(=O)N(CCN(C)C(=O)C2=NC(Cl)=CS2)C(C)C)C=C1 CCC1(C(=O)N2CCC[C@@H1](N3C[C@@H1](C4=CC=CC=C4)C(C)(C)C3)C2)CC1 CO[C@@H1](C1=CC=CC=C1)[C@@H1](C)NCC=2C=CSC=2NC3=CC=C(C)C=C3 C=CC(C)(C)CC(=O)NC[C@]12C[C@@H1]1CN(C(=O)[C@H1]3CCSC3)C2 O=C(N[C@@H1]1CC2=CC=C(Cl)C=C2C[C@H1]1CO)[C@@H1]3CCC3(F)F CCN(CC1CCN(C(=O)[C@@](C)(OC)C2(C)CC2)CC1)C(=O)CCN(C)CCO C=CCC[C@H1](NC(=O)C(C)(C)CN(C)C(=O)[C@H1]1CCC(C)=C(C)C1)C2CC2 C[C@]1(CC(=O)N2C[C@@](NC(=O)C3=CC=C4C(=C3)COC4)CC[C@H1]2C)CCCO1 CC1=NC=C(CCC(=O)NC[C@@]2(C)CCN(C(=O)[C@@H1]3CCCCC(=O)N3)C2)S1 CSC1=CC=C(OCC(=O)N[C@@H1]2CCC[C@@H1]2NC(=O)CC3=CC=C(O)C=N3)C=C1 CC1=C(Cl)C=CC=C1OCC(=O)N[C@@H1]2CC[C@@H1](CNC(=O)C3CC4(CSC4)C3)C2 C#C[C@@H1](CNC(=O)[C@@H1]1CCCN(C(=O)C2=CC=CC(=O)O2)CC1)C(C)C O=C(CC1(O)CCC1)NCC[C@H1]2CC=CCC2 CO[C@@H1]1C[C@H1]2C[C@H1]([C@H1](NC[C@H1](C)C(C)C)C3=NN=NN3C4CCOCC4)C[C@H1]21 CN1N=C(C(=O)NC[C@@H1]2CCN(C(=O)C(C)(C)C3=CSC=N3)C2(C)C)C(Cl)=C1Cl CC1=CC=C([C@]2(O)CCN(C(=O)C3(CC(F)F)CC3)C2)C=C1 CCN1N=CN=C1C(=O)N2CCC[C@@H1](C3CN(C(=O)[C@@H1]4CC=CC[C@H1]4C)C3)C2 C[C@@H1]1[C@H1](CC2=CC=CC=C2)CCN1CC3=CC(C4=CC=C5C=CN=CC5=C4)=CS3 CNC[C@H1]1CCC[C@H1]1N2C=CN=C2C3=CC=CC(C4=CC=C(F)C=N4)=C3 O=C(CCC(=O)C1CC1)N[C@H1]2C3C[C@H1]4[C@@H1](C3)C24C(=O)N[C@H1](CF)C5=CC=CC=C5 CC1=NSC=C1CC(=O)N(C)[C@H1]2CCCCN(C(=O)C3(C4CCC4)CC3)C2 C=C(C)CC(=O)N1CC[C@H1](N(C)C(=O)[C@@H1](CC)C2=CC=CC(Cl)=C2)C1 CCN1N=C(C(=O)N[C@@H1](C)CN(C)C(=O)CC(C)(F)F)C=C1O COCCN(C(=O)N(C)C1=CC=C(C)C=C1)C2CCN(C)CC2 CCCC=CC(=O)N[C@H1]1C[C@@H1]2CN(C(=O)CC3=CC(O)=CC=C3Br)C[C@@H1]2C1 CC1(C)CC2(C[C@@H1]2C(=O)N3CCC[C@@H1](NC(=O)C4CCC(C)(O)CC4)C3)C1 CO[C@H1](C)C(=O)N[C@H1](CNC(=O)C(N)=O)C1CCCCC1 N=C1[NH1]C(C(=O)NC[C@@H1]2CN(C(=O)C3=C[C@]4(CCOC4)C3)C5(CCC5)C2)=CS1 NC(=O)C1=CN=CC(C(=O)N2CC[C@@H1](NC(=O)CC=3C=NOC=3)[C@@H1](O)C2)=C1 CCN(C)CC(=O)N1CC([C@H1]2CN(C(=O)[C@H1]3CCCN4C=NN=C43)CCO2)C1 CC1(NC(=O)C2=CC=C[N+1]([O-1])=C2)CCN(C(=O)CC3C[C@@H1]4C[C@H1]4C3)CC1 C=C(CCNC(=O)C1CCSCC1)CNC(=O)[C@@H1]2CCC[C@H1](C(N)=O)C2 CC(=O)O[C@H1](C(=O)N[C@@](C)(CO)CNC(=O)C1CCC(C2CC2)CC1)C(F)(F)F CO[C@@H1](C)C(=O)N1CC(O)([C@@H1](C)NC(=O)C[S@@](=O)C2=CC=C([N+1](=O)[O-1])C=C2)C1 CC1=CC(C(=O)NCC[C@@H1]2CCN(CC(=O)N3CCC[C@@H1](C(N)=O)C3)C2)=NS1 CCN1C[C@H1](C)N([C@@H1](C(=O)NCC(C)C)[C@H1]2C[C@@H1](OCOC)C2)[C@H1](C)C1 CCN(CC(C)(C)CNC(=O)C[C@H1]1C[C@@H1]1C)C(=O)C2=CN(C3=CC=CC=C3)N=N2 CCNC(=O)CN(C)[C@H1](C(=O)NC1CCOCC1)C2=CC=CC(Cl)=C2SC CCC[C@H1](CO)NC(=O)[C@@H1]1[C@H1](CC)CCCN1C(=O)[C@@H1]2CC23CCCCC3 C=C1C[C@@H1](C(=O)N[C@@H1]2C3=CC=CC=C3C[C@H1]2NC(=O)C4=CN=C(OCC)S4)CC1 COC1=NC(C(=O)N(C)CCCNC(=O)[C@@H1](C(C)C)N(C)C)=NC=C1F CCCSCCC(=O)NC[C@H1](C)C1CCN(C(=O)[C@H1]2COC(=O)C2)CC1 CS(=O)(=O)NCC(=O)N[C@]12C[C@H1]1CN(C(=O)C3=CC(Cl)=CC=C3N4C=CN=C4)C2 CC1=CC=C([C@@H1](C)NC(=O)C(F)(F)CC2CC2)S1 CCC[C@]1(CO)CCCN1C(=O)[C@@H1]2CN(C(=O)[C@@H1]3C[C@H1]3C#N)CC2(C)C O=C(NCC1=CC=CC=2[NH1]N=CC1=2)N[C@@H1]3CC[C@@H1](C4=CC=CC(F)=C4)C3 C[C@H1](C#N)C(=O)NCCC1(O)CN(C(=O)C2=CN(C)N=C2C3CCCC3)C1 CC[C@@H1](C)C1=NC(C)=CC(N(C)[C@H1]2CCN(C(=O)C3=CC=CC(OC)=C3)C2)=N1 CC1=CC=C2OC=C(CC(=O)N3CC[C@H1](NC(=O)C=C4CC4)[C@@H1](C(C)C)C3)C2=C1 CC[C@@H1](CCOC)C(=O)N[C@@H1]1CN(C(=O)COCC2=CC=CC(C)=C2)C[C@H1]1OC CN(CC1=CC=CO1)C(=O)[C@]2(C)CCCN2C(=O)C3=CC(F)=CC=C3O O=C(C1=CC=C([N+1](=O)[O-1])[NH1]1)N2CC[C@H1]3C[C@]32C(=O)NCC4=CC=CN=C4 O=C(CSC1=CC=C(F)C=C1)N[C@H1]2CCC23CN(C(=O)C=4C=CSN=4)C3 CCC=CC=CC(=O)NCC1[C@@H1]2CN(C(=O)[C@@H1]3CCCCN3C)C[C@@H1]12 CN(C)[C@@H1](C(=O)NCCN1CCN(C(=O)[C@H1]2C[C@H1]2C(N)=O)CC1)C3=CC=CC=C3 COCC1(C(=O)N2CCC[C@H1](N(C)C(=O)CC[C@@H1]3CCCO3)C2)CCC1 CCOC1=NC(C(=O)N[C@H1]2[C@@H1](C(=O)O)[C@H1]3CCCC[C@H1]32)=CO1 CCC[C@H1](C)C(=O)NC1CCC2(CC1)CC(NC(=O)C[C@@H1]3COC[C@H1]3O)C2 CSCC[C@@H1](O)C(=O)NC12CC(NC(=O)C=3C=NN4C=3OCC(C)(C)C4)(C1)C2 C[C@@H1]1CCC[C@@H1](NC(=O)N[C@]23CCCC[C@H1]2N(C(=O)C4=CN=N[NH1]4)CC3)[C@@H1]1C CCOCC(=O)N(CC)CCNC(=O)CCNC(=O)CO CCC(CC)CC(=O)N1CC(CCNC(=O)[C@@]2(C)C[C@H1](C)O[C@H1](C)C2)C1 COC1=NC=C(Cl)C(C(=O)N2CC(CN(C)CC3=C(O)C=CC=C3Cl)C2)=C1Cl C#CCCCOCC(=O)NC[C@H1]1CCCC[C@@H1]1NC(=O)C2=N[NH1]C(C)=C2C CCN(C(=O)[C@@H1]1[C@H1]2CC[C@H1]21)[C@H1]3CCN(C(=O)C4=CC(Cl)=C(Cl)S4)C3 C#CC1=CC=C(C(=O)N[C@@H1]2C[C@H1](NC(=O)C3=CN=CC(CO)=C3)C24CCC4)C=N1 CSCCCC(=O)N[C@@H1]1CC[C@H1](CNC(=O)C2=CN3C=CN=CC3=N2)C1 CSC1=NC(O)=NC(C)=C1C(=O)NC[C@@H1](C)C2CCN(C(=O)C(C)(C)SC)CC2 C[C@H1](CC(=O)N1CCC(F)(F)C1)N(C)C(=O)C2C[C@@H1]3CCC[C@H1]3C2 CC(C)=C(Br)C(=O)N[C@@H1]1CN(C(=O)C2=COC3=C(F)C=C(F)C=C23)C[C@@H1]1C COC(=O)C1(NC(=O)[C@H1](C2=CC=NS2)N(CCCO)C3CC3)CCCC1 CC1=NC(N2CC[C@@H1](C3(NC(=O)C4=CC=NN4C)CC3)C2)=C(Cl)C=C1[N+1](=O)[O-1] CCOC=1OC(C)=NC=1C(=O)N[C@@H1](CC)CNC(=O)C[C@@H1]2C[C@H1](O)C23CCC3 CC[C@H1](C(=O)N1CCN(C(=O)[C@@H1](O)C=2C=CSC=2)C[C@H1]1C)[C@@H1](C)O CC[C@H1](CCOC)C(=O)N(C)CC1(NC(=O)C2=CC(C(N)=O)=CC=C2C)CC1 C[C@@H1](CC(=O)N[C@H1]1CN(C(=O)C2=CC=CN=C2F)CC[C@H1]1CO)C3=CC=CC=C3 COC[C@@]1(CNC(=O)[C@H1]2CC2(F)F)CCCN1C(=O)C3=CC=C(S(N)(=O)=O)O3 CC(C)(C(=O)NC[C@H1]1CCCN1C(=O)[C@H1]2CC23CCOCC3)C4=CC=C(Cl)C=C4 CC(F)(F)C(C)(C)CC(=O)N1[C@H1]2CC[C@H1]1CN(C(=O)[C@H1](F)C(F)(F)F)C2 CC(C)(C(=O)N1CC=C[C@H1](C(=O)N2CC[C@@]3(CCCO3)C2)C1)N4C=NN=N4 C=CC[C@@]1(C(=O)NCCC2(O)CCCCC2)CCN(C(=O)[C@H1](C)OC)C1 CC(C)C#CC(=O)NC[C@H1]1CC[C@H1]1C(=O)N2CCC[C@@H1]2CC(N)=O CCN1C[C@H1](C(=O)NCC2CN(C(=O)CCS(=O)(=O)NC)C2)CC1=O CCC(CC)(CCNC(=O)[C@H1](C)CC1=CC=NC=C1)NC(=O)C=CC2CCCC2 CCC[C@@H1](CN=C(NCC(=O)N(C)CC(F)(F)F)N[C@H1](C)COC)OC C=C[C@H1]1CN(C(=O)C2=C(C)C(C)(C)OC2=O)C[C@H1]1NC(=O)[C@H1]3CCOCC3(C)C COC1=CC=CC=C1C(=O)NC[C@]23CC[C@@H1]2CCN3C(=O)C4=CN(C(C)C)N=N4 O=C(NCCC1=C(F)C=CC=C1Cl)[C@@H1]2C[C@@H1]2NC3=NC=NC4=C3CCC4 O=C(CC[C@@H1]1CCCCN(C(=O)CN2C=CC=NC2=O)C1)NCC3=CSC=N3 C[C@@H1](CN1CCN(C(=O)C2=CC(F)=CS2)CC1)NC(=O)[C@H1]3C[C@H1](N(C)C)C3 C[C@@H1]1C[C@@H1](C)N(C2=NC=NC=C2C#N)CCN1C(=O)OC(C)(C)C C#CCOCC(=O)N[C@@H1](CC)CNC(=O)CCC1=NN=C(O)N=C1O COCCCNC(=O)CCC(=O)N1CC2(CCC[C@@H1]2NC(=O)C3=CC(F)=N[NH1]3)C1 C[C@H1](CCNC(=O)C1=CN(C)C2=CC=CC=C12)NC(=O)[C@H1](C)CC3CCC3 CC1=CSC(C(F)(F)C(=O)N[C@H1]2CC[C@H1](NC(=O)CN3CC(C)C3)CC2)=N1 CCN1C[C@H1](C(=O)N[C@@H1]2C[C@@H1]2[C@@H1]3CCCN(C(=O)C45CC(CO4)C5)CC3)CC1=O C[C@@H1](CN(C)C(=O)CC1CCC2(CCCC2)CC1)N(C)C(=O)CC3=NN=C(O)S3 CC1(C)CN(CC2=NC3=CC=CC(Cl)=C3N2C)[C@H1]1C4=CC=CO4 C#CC1(C)CCN(C(=O)[C@H1]2CCC[C@H1]2NC(=O)C=3C=CC4=N[NH1]C=C4C=3)CC1 CO[C@]1(C(=O)NCC2CN(C(=O)CCCC#N)C2)CCS(=O)(=O)C1 CN(C)C(=O)O[C@@H1]1CCN(C(=NCCC2=CN=CS2)NC[C@H1]3CCOC3)C1 COC1=CC=C(C(=O)N[C@H1]2CCC[C@H1]2C(=O)N(C)CC3=CC=CN=C3)N=N1 CC1(NC(=O)[C@H1](F)C2CCC2)CN(C(=O)C=CC3=CC=CC=C3F)C1 CCCSCCC(=O)N[C@H1](CNC(=O)C1=CC(O)=C2C=COC2=C1)C3CC3 COC1(C(=O)N[C@@H1]2CN(C(=O)C3CSC3)CC[C@H1]2C)CCOCC1 CC1(C)C[C@H1](CNC(=O)C2C[C@H1]3CC[C@H1](C2)C3)CN1C(=O)C45CC(CO)(C4)C5 CCCCOCCNC(=O)[C@@](F)(CNC(=O)[C@H1](OC)C1CC1)C(C)C CC[C@@H1](CCC(=O)N[C@@H1]1C[C@@H1]1CNC(=O)CCOC2=CC=CC(C)=C2)OC CN1CCN(C2=CC=CC=C2C(=O)NC3CN(C(=O)[C@@H1]4CC[C@H1]4C(N)=O)C3)CC1 C[C@@H1](CC1CCOCC1)N=C2C=CC(C3CCCCC3)=C[NH1]2 CCO[C@]1(C(=O)N2[C@H1]3CC[C@H1]2CN(C(=O)[C@H1]4C[C@]5(COC(=O)N5)C4)C3)CCOC1 C[C@@H1](C(=O)N1CC(CNC(=O)C=2C=CC3=CC=NN3C=2)C1)C4CCC4 COCC1(C(=O)N2CC[C@@H1](NC(=O)C3CC4=NC=CN=C4C3)[C@@H1](C(C)C)C2)CC1 CCC[C@@H1]1CCCCN1C(=O)[C@H1]2COCCN(CC3=CN=CS3)C2 C[C@@H1](NC(=NCC(C)(C)CS(C)(=O)=O)N(C)CCN1CCCS1(=O)=O)C2CC2 C[C@H1]1CCN1CC(=O)N[C@@H1](CO)CNC(=O)C2(C3=CC=C(F)C=N3)CC2 CC1=CN=C(NC(=O)C2CCN(C3=NC=C(C4=CC=C(O)C=C4)C=N3)CC2)S1 C#CC[C@H1](CC(=O)N[C@@H1](C)CC1=NC=CN1C)NC(=O)C(C)=CCCC CC=C1C=CC(C2(C(=O)N3CC(OCCNC(=O)C=C[C@H1]4CCCO4)C3)CCC2)=C1 CC(C)=CCCC(=O)N[C@@H1]1CC[C@H1](N(C)C(=O)CCN(C)CCO)C1 C=CC[C@H1](CC(=O)NCC(C)(C)N1C=CN=C1)NC(=O)CSCC(N)=O FC(F)OC1=CC=CC=C1OC[C@@H1]2CC[C@H1](C)N2CC3CCSCC3 CC[C@@H1](CNC(=O)C1=CC(C2=CC=CN=C2)=NN1C)NC(=O)[C@@H1]3CCOC3(C)C CCCN(C)CC(=O)N[C@@H1]1C[C@H1](C)N(C(=O)C=2C=C(C3CCC3)[NH1]N=2)C1 CC(C(=O)N[C@H1](CO)[C@@H1](C)NC(=O)C=1C=CC(=O)N(C)N=1)=C2CCC2 CN1N=C(C(F)(F)CF)C=C1C(=O)NC[C@@H1]2CC[C@@H1]2NC(=O)CCC(N)=O CC1=NO[C@@H1](CC(=O)NC2C(C)(C)CN(C(=O)CCC=3C=CSC=3)CC2(C)C)C1 C#CC[C@]1(C(=O)N2CC(C3=NOC(C)=N3)C2)CCN(C(=O)C4=CN=N[NH1]4)C1 CCC1=CC=C(C(=O)N[C@H1](CN(C)C)C(=O)N2CC(F)(F)C(F)(F)C2)S1 CC=1C=C(CO)OC=1C(=O)N(C)C2CCN(C(=O)C[C@H1]3CCCOCC3)CC2 CSCC1(CC(=O)NC[C@@]2(NC(=O)CCC(C)(F)F)CC3CCC2CC3)CC1 CC1=NC(C)=C(C2=NC3=C(S2)C[C@@H1](C(=O)NCC4=CC=CC(C(F)F)=C4)CC3)S1 COC1=CC(C)=NC(C(=O)NC2CC(N(C)C(=O)C(C)(C)NS(C)(=O)=O)C2)=C1 CCC[C@@H1](C(=O)NC[C@@H1](CCOC)NC(=O)C1(C)CC=CC1)S(N)(=O)=O O=C(N[C@@]1(CO)CCN(C(=O)C(F)(F)C(F)F)C1)C2=CC(F)=CC(C(F)F)=C2 CC(C)=CC(=O)N1CCC[C@@H1](CCNC(=O)C2=N[NH1]C3=CC=C(Br)C=C23)CC1 CC=CC=CC(=O)NC[C@H1]1COC[C@H1]1NC(=O)C2=C(C3=CC=CC=C3)C=NN2C CC[C@@H1]1C[C@H1]1C(=O)NCC[C@H1]2C3N(C(=O)C=4SC(C=5C=CSC=5)=NC=4C(C)C)C[C@H1]23 COC1=CC=C(CCC(=O)N[C@@H1](C)CCNC(=O)C[C@@H1]2C[C@H1]3C[C@H1]3C2)C=C1 CC[C@H1](C)C[C@@H1](NC(=O)C1=COCCC1)C(=O)N2CCC[C@@](C)(F)C2 CC=1C=C[NH1]C(=NCCCN(C)C2=CC=CC=C2F)C=1 C[C@H1](CC(=O)NCCC1=CCCCC1)N(C)C(=O)C2CC3(CCC3=O)C2 COC1=CC(OC)=CC([C@@H1]2CCN(C[C@@H1]3OC(=O)NC3(C)C)C[C@H1]2C#N)=C1 CN1C=CC=C1CN2CCN([C@@H1](C(=O)NCC3CC3)C4=CC=CC=N4)CC2 CC[C@H1](C(=O)NC1(COC)CN(C(=O)C2=CN=C3N=CC=CC3=C2)C1)[C@@H1](C)O COCCCCCC(=O)N1CCC(F)(C(=O)N2CC[C@@H1](C)[C@@H1](C)C2)CC1 CO[C@@H1](C)CC(=O)N[C@]1(C2CC2)CCN(C(=O)C=CC3=CC=CC([N+1](=O)[O-1])=C3)C1 C[C@@H1]1CC[C@H1](O)[C@H1]([C@@H1]2CCCN2C(=O)N[C@@H1]3C(=O)OC[C@H1]3C4=CC=CC=C4)C1 OC=C1N=NC2=CC=CC=C2[NH1]C1=N[C@H1]3CCC4=C(Cl)C=CN=C43 C[C@@H1]1C[C@@H1](C(=O)NC23CC(C2)N(C(=O)C=4N=C5N=CC(CCO)=CN5N=4)C3)CO1 N#C[C@@H1]1CCC[C@@H1]1N=C2[NH1]C(=NC[C@H1]3C[C@H1](C[C@@H1]3CO)C)[NH1]C4=CC=CN=C24 C[C@@H1]1C[C@@H1](NC(=O)C=2[NH1]C=CC=2C3CC3)CN(C(=O)CC=4C=C(C5CC5)ON=4)C1 C[C@]1(O)C[C@@H1](C(=O)NC2CCN(C(=O)C=3N=CSC=3C(F)(F)F)CC2)C1 O=C(NCC[C@@H1]1CSCCN1C(=O)[C@H1]2CC(C3=CC=CC=C3F)=NO2)C4=CCC4 CC(C)(C(=O)N[C@H1]1C[C@@H1](CO)N(C(=O)CCCCC#N)C1)C2CC2 CC[C@H1](SC)C(=O)NCCN(CC)C(=O)C=C(C)CCC C#CC1=CN=CC(C(=O)N2CCC[C@@]3(C[C@H1](NC(=O)CC(C)C)CO3)C2)=C1 CCCCO[C@H1](C)C(=O)N1C[C@H1](O)C[C@@H1]1CNC(=O)C2=CN=C3N=CC=NC3=C2 O=C(N[C@@H1]1[C@H1]2CCN(C(=O)C3=CN=C(O)O3)[C@H1]21)C4=CC(CO)=CC=C4Cl CC(C)NC(=O)C1=CC=C(C(=O)N2C[C@H1]3[C@H1](NC(=O)CN4C=NN=C4)[C@H1]3C2)C=C1 C[C@@H1](C(=O)N1CCOC[C@H1](NC(=O)C=2C=CSC=2Cl)C1)C3=CC=CC=C3 CCN1N=C(C)C(C(=O)N2C[C@H1](C(=O)N3CCC[C@H1](C4(C)CC4)C3)C(C)(C)C2)=N1 CCOC(C)(C)C(=O)NC[C@@]12CCC[C@H1]1CCN2C(=O)C=3[NH1]C(O)=NC=3C CCCC[C@H1](NC(=O)OC(C)(C)C)C(=O)NCC(C)(C)NC(=O)CC[S@@](C)=O CCC1=CC=C(O)C(C(=O)NCC2CC(NC(=O)C3=CC(F)=C(Cl)C=C3F)C2)=C1 CSC1=CC=C(C(=O)N2CCCC[C@H1]2CC3=CN([C@H1]4CCOC4)N=N3)O1 O=C1CC(C(=O)N2CC(CCNC(=O)C3(C4CC4)CC3)C2)=NN1 CC(C)(C)OC(=O)[C@@]1(C(=O)N2CCO[C@H1](C3=CC=CC(F)=C3)C2)C=CCC1 CC(C)(C[C@@H1](F)C(=O)N[C@@H1]1CCC2=NC=NN2C1)NC(=O)C(F)F CC[C@@H1](C)CCCC(=O)NC[C@](C)(O)CNC(=O)C1=CC=C(C(=O)OC)N=C1 C[C@H1]1OCC[C@@]1(C)C(=O)NCC2(NC(=O)CC3=CC(F)=CC(Br)=C3)CC2 C=CCC(CC=C)NC(=O)[C@H1]1C[C@@H1](C)CN(C(=O)CN2C=CC(C)=N2)C1 CC=1N=C(NC(=O)C2C[C@@H1](NC(=O)C3SCCS3)CC2)SC=1Cl CC1=NN(C)C=C1C(=O)NC[C@H1]2C[C@@H1]2CNC(=O)C=3OC=NC=3C(F)F CC(C)N1C=CC=C1C(=O)N2C[C@H1](CNC(=O)[C@@H1]3C[C@H1](C)CO3)[C@H1](C(F)(F)F)C2 C[C@H1](CNC(=O)CNC(=O)C=1C=CSC=1)[C@]2(O)CCN(C(=O)C3=COCCC3)C2 C=C=CCC(=O)N1CCN(C(=O)C2=CC(Br)=C(C)O2)C[C@H1]1CO CO[C@]1(CNC(=O)CC2=CC=C(Br)C=C2C#N)CCN(C(=O)OC(C)(C)C)C1 C=C[C@H1](CC)CC(=O)N[C@H1]1CCC[C@H1]1NC(=O)C2=CN(CC)N=C2C(C)C CC(C)CN1C[C@@H1](C(=O)NC2CN(C(=O)CC[C@@H1](C)C#N)C2)CC1=O CC1=CC=CC=C1CC(=O)N[C@@H1]2CN(C(=O)[C@H1]3C[C@@H1](O)C3)C[C@@H1]2N4C=CC=N4 COC1=CC=NC=C1CC(=O)N2C[C@H1](NC(=O)C3=CC=CN=C3)[C@H1](OC)C2 CCCC1=NC2=CC(C(=O)NC[C@@H1](C)CN(C)C(=O)C3(CCC)CC3)=CC(C)=C2[NH1]1 O=C(NCC#CCNC(=O)[C@@H1]1CCC2(CCC2)O1)C=3C=C(C4=CC=CC=N4)[NH1]N=3 CC1(CNC(=O)[C@@H1]2CC3CC2C3)CCN(C(=O)[C@@H1]4CCCN4N=O)CC1 C[C@H1](ONC(=O)[C@@H1](N)C1=CC=CC2=C1CCC2)C3=CC=CC=C3 CN1C=NC(C=CC(=O)N2CC3(C2)SCC[C@@H1]3NC(=O)C4=C[NH1]N=C4F)=C1 C[C@@H1]1CN(C(=O)[C@H1]2C[C@@H1]2C3=CC=NC=C3)CCCN1C(=O)C=4SC=CC=4CC#N CCC1=NN(C)C(C(=O)N2CCOC3(C2)CN(C(=O)CCC4=NC=CS4)C3)=C1Cl CC(C)[C@H1](C(=O)N[C@H1]1CN(CC2=NC=CN2C)C[C@H1]1CC#N)C3=CC=CN=C3 CC[C@@]1(NC(=O)C2=CC=CC=C2F)CCCN(C(=O)[C@H1]3CCC(=O)N(C)C3=O)C1 C=C[C@@H1](C)ONC(=O)C1(C)CN(C(=O)CN2N=NN=C2C)C1 CC1=NC=C(C(=O)NCC(=O)NCC(=O)N[C@H1](C)C2=CC=CC=C2F)S1 CC=1C=CSC=1CC(=O)N[C@@H1]2CC(C(=O)NCC[C@H1]3CC(C)(C)CO3)=C[C@@H1]2O C#CCCCC(=O)N[C@@H1](C(=O)O)C1=CC(C)=CC=2C=COC1=2 COCC1=NC(C(=O)N[C@H1](C)[C@H1](C)NC(=O)C2(C3=CC(F)=CC=C3C)CC2)=CS1 CC(C)C[C@](C)(CNC(=O)C(C)(C)N(C)C)NC(=O)CCC1=CC=CN=C1Cl CC[C@H1]1CCCN(C(=O)CCC2=CON=C2C)[C@H1]1C(=O)N3C[C@H1](C)O[C@H1](C)C3 N#CC1=C(NCCNC(=O)[C@H1]2CCCCN2N=O)N=CC3=C1CCCC3 C=C1CC(C(=O)NCCCCNC(=O)[C@@](C)(CC)CCCCC)(C(F)(F)F)C1 CC(C)(O)C(F)(F)C(=O)N1C[C@@]2(NC(=O)C[C@H1]3C=CCC3)CCC[C@@]2(F)C1 CSC1=CC(C)=C(C(=O)NC2(C3(O)CCN(C(=O)C4=CC=C(C)[NH1]4)CC3)CC2)O1 C=CCOC1=CC=C(C(=O)NCCC2=CC=C3C(=C2)OCCC3)C=C1OC CC[C@H1](COCC1CC1)NC(=O)NN2CCOCC2 CN1CC(C)(C)C[C@@H1]1C(=O)NC[C@H1]2[C@@H1]3CN(C(=O)C[C@@H1]4CSCCS4)C[C@H1]23 CCC1CCC(N(C)C(=O)C2(CCNC(=O)[C@@H1]3C[C@@]3(C)CC)CCCC2)CC1 C[C@H1](N=C1NCC2=CC=CC2=C1CC(=O)O)[C@H1]3CCCN(C(=O)OC(Br)(C)C)C3 CC1CCN(CC(=O)N2CCCO[C@H1](CNC(=O)[C@@H1]3CCCSC3)C2)CC1 CSC(C)C(=O)N1C[C@@H1]2CCC[C@]2(CNC(=O)C3=C(C)C=CC4=C3CCCN4)C1 CC1=CSC(C(=O)NC/C=C/CNC(=O)CC=2N=C(C)SC=2Cl)=C1Cl C[C@]1(NC(=O)[C@@H1]2CC[C@@]3(C2)CC3(F)F)CCN(C(=O)C4=CC=C(CO)C(F)=C4)C1 CC1(C(=O)NC[C@H1]2C=CCN2C(=O)[C@@H1](C#N)C3CC3)CCCCC1 CC(C)(C)[C@](C)(O)C(=O)N[C@H1](CNC(=O)C=1C=C(C2=CC=CC=C2)[NH1]N=1)C3CC3 C#CC[C@@H1](O)C(=O)NC[C@@H1]1C[C@H1](COC)CN1C(=O)C=2OC=C(C)C=2C O=C(NCCN1CCN(C(=O)C=CC2=COC=N2)CC1)C3=NO[C@@H1]4COC[C@H1]34 CC(=O)OCC(=O)N1C[C@H1](O)[C@@H1](C2=CN(C[C@H1]3CCOC3)N=N2)C1 O=C(CN=C1C=C[NH1]C=C1)N2C[C@@H1]3CC[C@H1](C2)N3C(=O)C4=CSC5=CC=CC=C45 CN(C(=O)CC1=CC=CC(Cl)=C1Cl)[C@H1]2CCCN(C(=O)/C=C/[C@@H1]3CCCO3)C2 C=CCCCCCC(=O)NCC[C@@H1](NC(=O)C1=CC(F)=C(F)C(F)=C1F)C(C)C COC(=O)C1=CC=CC(OCCN2CCC[C@]3(C2)OC[C@H1]4C[C@H1]43)=C1 CN(C1=NN=C(C2=CC=CN=C2)N1C[C@H1]3CCCC3(F)F)C[C@](C)(O)C(F)(F)F C=C(CCNC(=O)[C@H1]1C(C)(C)C1(F)F)CNC(=O)[C@H1]2CCN3N=CN=C3C2 CC(C)[C@@H1]1C[C@H1](C(=O)N2CCC[C@@H1](N(C)C(=O)CN3CCC(O)CC3)C2)CCO1 C[C@H1](CN(C)C(=O)C1=CC=C(C2(C)CC2)C=C1)NC(=O)C3=NC=CC(Cl)=C3Cl O=C(N[C@H1](CNC(=O)[C@@H1]1CCO1)C2=CC=CC(Cl)=C2)C3=CN(CC(F)(F)F)C=N3 CC(C)[C@]1(C)C[C@@H1]1C(=O)N[C@H1]2C[C@](C)(NC(=O)C3CN(C(=O)N(C)C)C3)C2 C[C@H1](NC(=O)CCCC(F)(F)F)C1CN(C(=O)C2=CC(Br)=CO2)C1 CC1=CC=C(C)C(C(=O)N2CC(N(C)C(=O)CC3=NN=C(S)N3C)C2)=C1N COC[C@]1(C(=O)N[C@H1](CNC(=O)CN(C)C2=NC=CC=N2)C3CC3)CC=CCC1 CC[C@@H1]1CN(CC=2C(C)=NOC=2C)CCN1C(=O)C3=CC=CC(Cl)=C3C C[C@@H1](C(=O)N(C)C[C@H1](O)CNC(=O)CN1C=NC([N+1](=O)[O-1])=C1)C2=CN=CN=C2 COC=1SC=CC=1[C@H1](NC[C@@H1]2CC3(CCO2)CC3)C4=NN=NN4CC(F)F CC[C@@H1](C)NC(=O)[C@@H1](C)NC(=O)C=1C=C(CNC(=O)C=2N=C(C)OC=2C)ON=1 C[C@H1]1CCN(C(=O)CCS(C)(=O)=O)C[C@H1]1CNC(=O)CN(C)C CC=1[NH1]N=C(C(=O)N2C[C@H1](CNC(=O)C(C)(C)CC(F)F)C3(CC3)C2)C=1F CCC[C@H1](NC(=O)CC[C@@H1](CC)NC(=O)CN1CC[C@H1](C)C1)C(=O)OC CCC1=CC=C(C(=O)N2CC[C@@H1](C)[C@@H1](NC(=O)C3=CSC(C(C)C)=N3)C2)C=C1F CCC[C@H1](C)N(C)CCC(=O)NC[C@H1](CC)NC(=O)C1=C(C)C=C(OC)C=C1F CC=C(F)C(=O)N[C@@H1](C)CC1CCN(C(=O)C2=C(C)C=CC(F)=C2O)CC1 CC=1C=COC=1CC(=O)NC/C=C/CNC(=O)[C@@H1]2[C@H1]3CC[C@@]2(C4=CN=CS4)C3 CCNC=1SC=NC=1C(=O)NC[C@@](C)(F)CNC(=O)CCCC(C)(C)C CC1(C)CCCC[C@@H1]1C(=O)N[C@H1]2CN(C(=O)C3=NC=NC=4C=CSC3=4)CC25CC5 CN=C1[NH1]C=C(C(=O)N2CSC[C@H1]2C(=O)N3CC[C@@H1](C=4N=C[NH1]N=4)C3)S1 O=C1CCCN1CC(=O)N2CCN(C(=O)C3=CC(Cl)=CC=N3)CC2 CS(=O)(=O)C1=CC(C(=O)N2CCC[C@H1](NC(=O)C=3C=CON=3)C2)=CO1 C[C@@H1](CC(=O)N[C@@H1]1CN(C(=O)/C=C/C2(C)COC2)CC1(C)C)C3=CC=CC=C3 C=C(C)CC[C@H1](C)N=C1C=CN2N=CC(S(=O)(=O)N3CC[C@@H1]4COCC[C@@H1]43)=C2[NH1]1 O=C(CSC1=CC=C(Cl)C2=CC=CC=C12)NC3CN(C(=O)C=4OC=CC=4F)C3 C=CN1N=CC=C1C(=O)N[C@@H1](C2=CC=CC=C2)[C@@H1](C)NC(=O)CCN3C=CC=C3 CC1=CC=CC([C@H1](C)C(=O)N[C@H1]2CCN(C(=O)C=3C=CN(CCF)N=3)[C@@H1](C)C2)=C1 CC=C(C)C(=O)N1CC(C)N(C(=O)[C@H1]2CN(C)C=N2)CC1C CC1(C#CC(=O)NCCOCCC(=O)NC(C)(C)CS(C)(=O)=O)COC1 C/C=C/C[C@@H1](C)C(=O)NCC12CC(CN1C(=O)C=CC3=CN=C(C)S3)C2 COC1=CC(F)=CC(C2=NOC([C@@H1](NCC3=CSC(Br)=N3)C(C)(C)C)=N2)=C1 CC1=C(C(=O)N2CC[C@]3(CCN(CC4=C[NH1]C5=CC=C(F)C=C45)C3)C2)C=CN1C C[C@H1](CC(N)=O)C(=O)N1CCC[C@@H1]1CNC(=O)C=2C=NN(C3=CC=C(Cl)C=C3)C=2 O=C(N1CCN(CC2=CC=NC=C2)CC1)C(C3=CC=CC=C3)C4CCCCC4 CC(=O)NC[C@H1](CC(=O)N(C)CCNC(=O)C1(C)COC1)CC(C)C C=CC[C@@H1](NC(=O)CC[C@H1]1CC[C@@H1](NC(=O)C2(C=C)CCCC2)C1)C(=O)OC O=C(CC12CCC(CC1)C2)NC[C@H1]3CN(C4=NN=C(O)S4)CCC3(F)F C=CCCC1(C(=O)N2CC[C@@H1]3C[C@@]3(NC(=O)C4=CN=NN4C)CC2)CC1 CCC1(CC)CCN(C(=O)CN(CC2CC2)C(C)=O)C1 CC1=CC(NC(=O)C2=CC=CC(NS(C)(=O)=O)=C2)=CC=C1OC3=CC=CC=C3F C[C@@H1]1C[C@@H1]1C2=CC(C(=O)NC[C@H1]3CNCCCN3C(=O)OC(C)(C)C)=NO2 COC1=CC=CC(F)=C1C(=O)N[C@H1]2C[C@@H1]2C(=O)N[C@H1](C)CCCN(C)C CC(C)(C)[C@H1](CNC(=O)[C@](C)(F)C=1C=CON=1)C(=O)NC2CC(N3CCC3)C2 O=C(N[C@H1]1C[C@H1]2CC[C@H1]1CN2C(=O)C3CN(C4=NN=CS4)C3)C5=CC=C(CO)O5 CC[C@@H1]1C[C@@H1](CC(=O)N2CCOC3(C2)CN(C(=O)C4=CC=NN=C4C)C3)CCO1 CC[C@H1](F)C(=O)N[C@H1]1CCN(C(=O)C#CC2=CC=C(C(F)(F)F)C=C2)C13CC3 CC1=NN2C=C(C(=O)N3CC[C@]4(CCCN4C(=O)C[C@@H1]5CCCOC5)C3)N=C2S1 C[C@@H1]1CO[C@H1](C(=O)N2CC[C@H1](CN(C)C(=O)CCSC3=CC=C(F)C=C3)C2)C1 O=C(NC[C@H1]1CN(C(=O)[C@H1]2C[C@@H1](O)C2)CC[C@@]13CCOC3)C4=CC(C(F)F)=NO4 CC[C@H1](C(=O)NCC[C@H1]1CCCN1C(=O)C2=CC(O)=NC(C)=N2)[C@H1](C)O O=C(COCCC1=CC=CS1)NC2([C@@H1]3CCN(C(=O)[C@@H1](O)C4CCC4)C3)CC2 CN1CCC[C@]1(C)C(=O)N[C@@H1]2[C@H1]3C[C@@H1]4[C@H1]2[C@@H1]4[C@@H1]3C(=O)N5CC(F)C5 C#CC1=CN=CC(C(=O)NN2CCC[C@H1]2C(=O)N(C)CC(C)(C)CN(C)C)=C1 CC1=CN=CC(C(=O)N2CCN(C(=O)C3CN(CC(C)C)C3)CC[C@@H1]2C)=N1 CO[C@@H1](C(=O)N[C@@H1]1CC[C@H1]2C[C@H1]1CN2C(=O)C=3C=NN4C=CSC=34)C5CCC5 CC=CC(=O)N1C[C@H1](C)C[C@@H1](NC(=O)C[C@H1]2CC=CCC2)C1 COCCS(=O)(=O)N1CCN(C2=NC=NN3C=C(Br)C=C23)[C@H1](C(F)(F)F)C1 CN1C(=O)CCC[C@@H1]1C(=O)N2CC3CC2(C(=O)N4CC[C@]45CCCOCC5)C3 COC1=CC=CC(C(=O)N2CC[C@]3(CCCN(C(=O)CSC4CC4)C3)C2)=N1 CC1=CC(C(=O)N[C@H1]2[C@@H1](C(=O)NC[C@@H1]3CC[C@H1](C)C3)C2(C)C)=C(C)O1 C[C@H1](CC1=CC=CN=C1)C(=O)N(C)[C@@H1]2CN(C(=O)C3(C)COC3)C[C@H1]2O COC(=O)C=1C=C(CN[C@H1](C2=CC=C(CSC)O2)C3=NN=NN3C4CC4)N(C)C=1 CO[C@H1]1C[C@@H1](C(=O)NCCC2(NC(=O)[C@H1]3CC[C@@H1](N4C=CC=C4)CC3)CC2)C1 COC(C)(C)C(=O)N1CC[C@@H1](NCC2=CC=CC=C2C3=CC=CS3)C1 CO[C@@H1](CSC)C(=O)N1CCOC[C@@H1]1CCNC(=O)C2=CCSC2 CC1(NC(=O)[C@H1](F)CC2CCOCC2)CC(NC(=O)C3=C(F)C=NC=C3Cl)C1 CC=1C=C(CC(=O)N[C@H1]2CCN(C(=O)C3=CCOCC3)[C@@H1](C)C2)N(C)N=1 CC(=O)N[C@H1](C(=O)N(C)CCCCNC(=O)/C=C/[C@H1]1CCCN1C)C(C)(C)C O=S(=O)(N[C@H1]1CCCSCC1)C2=CC(C(F)(F)F)=CC=N2 O=C(N[C@@H1]1CCCC12CCN(C(=O)C3=CC=CC(O)=N3)CC2)C4=NC=CS4 C=C1CC(OC(=O)C2=CC=CC([C@H1]3CCOC3)=C2)C1 COC(=O)C1=CC=C(N(C)CCCN2CCOCC2)C3=CC=CC=C13 CC(C)[C@@H1](CNC(=O)C[C@H1]1CCCCO1)NC(=O)C=2C=COC=2N3C=NN=N3 CC1=CC=C2[NH1]C=C(CCC(=O)N(C)C3CC(NC(=O)CC45CC(C4)C5)C3)C2=C1 COC1=NC=C(Cl)C(=N[C@@H1]2CCN(C(=O)/C=C/C3=CC=C(F)C(Cl)=C3)[C@@H1](C)C2)[NH1]1 CC[C@H1](C)CCC(=O)N[C@@H1](C)CC1CN(C(=O)[C@H1](CC2=CC=CC=C2)C3CC3)C1 C[C@H1]1CN(C(=O)COC(F)F)CC[C@H1]1CNC(=O)C2=CSCCO2 CC1=CC(C(=O)NCC(=O)N[C@@H1]2CCN(C(=O)[C@]3(C)CCC(=O)N(C)C3)C2)=N[NH1]1 CN(C)C[C@@H1]1C[C@@H1]1C(=O)NC[C@H1](O)CNC(=O)C2=CC=C(Cl)C=C2Cl CC1=CC=CC(CC(=O)N2C[C@H1](C)[C@H1](CNC(=O)C3=CC=CN=N3)C2)=C1 CN1C=C(C(=O)NC[C@](C)(CO)NC(=O)C[C@H1]2CCCO2)C=C1S(N)(=O)=O COC1=CC=C(CCN2CCN(CC(N)=O)CC2)C=C1OC C[C@H1]1C[C@H1](CO)N1C(=O)C2C[C@@H1]3CC[C@H1](C2)N3C(=O)[C@]45C[C@H1]4CN(C)C5 CC1=CN=C(CN(C)C2=NC(N3C[C@@H1]4C[C@H1]3CO4)=NC5=CC=CC(F)=C25)C=N1 CC(CNC(=O)C1=CC(Br)=CC=C1F)(NC(=O)COC2=CC=CN=C2)C3CC3 N#CC1(C2=CC=C(C(=O)NC/C=C/CNC(=O)C[C@]3(O)CCOC3)C=C2)CC1 COC1=CC=CC(C(=O)N[C@H1]2CCC[C@@H1]2CNC(=O)C3=NC=CC(SC)=N3)=N1 CN(CCCCCC(=O)N1C[C@@H1](O)[C@H1](O)C1)C(=O)[C@@H1]2CC[C@H1](C3CC3)C2 CNC1=C(C(=O)N2C[C@H1](N=C3N=C(CC4CC4)[NH1]S3)C[C@@H1]2C)C=CC=C1[N+1](=O)[O-1] CCOC1=CC=C(C(=O)N2CC[C@@H1](C)[C@H1](NC(=O)CN=S(C)(C)=O)C2)C=C1 COCC(=O)N(C)CCOCCCN(C)C(=O)C=1C=CC(=NCCOC)[NH1]C=1 COC1=CC=C(C[C@@H1](O)CNC(=O)[C@@H1]2CC3CC2(C(=O)O)C3)C=C1 C#C[C@]1(O)C[C@@H1](C(=O)N2C[C@H1](O)[C@H1](NC(=O)C=3C=N[NH1]C=3)C2)C1 COC1=CC=C(C(=O)C(=O)NC2(C)CC(NC(=O)C3=CC=CN=C3S)C2)C=C1 CC(C)C1=N[NH1]C=C1C(=O)NC[C@H1]2CCCCCN2C(=O)CC[C@H1]3CCOC3 N#CCC1=CC=CC(C(=O)N[C@H1]2CCC[C@H1](NC(=O)C3=COC4=CC=CC=C34)C2)=C1 CCOCC(=O)N[C@@H1]1C=C[C@H1](CNC(=O)[C@@H1]2CC[C@@H1](C3=CC=CC=C3)C2)C1 CC(C)[C@H1](O)C(=O)N1CCC[C@H1](N(C)C(=O)CCC2=CC=CC(F)=C2)C1 C[C@H1](NC(=O)[C@@H1]1CCC2(CN(CC3=CC=C(Br)C=C3F)C2)O1)C=4C=CSC=4 CCC[C@H1](NC(N)=O)C(=O)NCCC1=CCN(C(=O)C2=C[NH1]C=C2CC)CC1 COC(=O)[C@@]12CC[C@@](CS(=O)(=O)NC3[C@@H1]4CCCNC[C@@H1]34)(C1)OC2 CSCCCCCC(=O)NC1(CC(=O)N(C)CC2CCN(C)CC2)CCC1 CCOC1=CN=CC(NC(=O)[C@@H1]2CN(CC3=CC=CN=C3Cl)CCC2(F)F)=C1 CC[C@@H1](CNC(=O)C(C)(C)CN(C)C(=O)[C@H1]1CCC2(CC2)C1)N3C=CC=N3 C/C(I)=C/C(=O)N[C@H1]1C[C@H1]2C[C@H1]1CN(C(=O)C(C)(F)F)C2 CCC[C@H1](NC(=O)N(CC)[C@H1]1CCC[C@@H1]1O)C2=CC=CC=C2 CN(C)CCCCC(=O)N1CC[C@@H1](CNC(=O)C2(C3=CC=CC=C3)CC4(CC4)C2)C1 CCCN1CCC[C@@H1](C(=O)N[C@](C)(CNC(=O)C(=O)C2CCCC2)C3CC3)C1 CCC1=CC(C(=O)NC[C@@H1]2C[C@H1](OC)CN2C(=O)C=CC3=NC=CC=C3C)=NO1 CO[C@@H1]1CC[C@]2(C(=O)N(C)CCCN(C)C(=O)[C@]3(O)CCCC(C)(C)CC3)C[C@H1]12 O=C(NCC1(C(=O)NC[C@@]2(O)CCCOC2)CCC1)C=3C=C4C=CC=CN4N=3 CO[C@@H1](C(=O)N1CC(C2(NC(=O)C3=CSC(=N)[NH1]3)CC2)C1)C4=CC=CC=C4F CC1CN(CC(=O)N[C@H1]2CC[C@H1](NC(=O)[C@@H1](C)C3=CC=C(Cl)C=C3)CC2)C1 CCN(CC(=O)C1=C[NH1]N=C1CN)C(C)C CC=1C=C(C(=O)NC2[C@H1](C)CN(C(=O)C3=CC(CO)=CC=N3)C[C@H1]2C)N(C)N=1 COCC1=CC=CC(NC(=O)C(=O)NC[C@@H1]2CC(C(C)C)=NO2)=C1 O=C(NC[C@H1]1CN(C2=NC=NC3=C2N=NN3CC4CC4)CC1(F)F)[C@H1]5CCCS5 CCC1=CON=C1C(=O)NCC2(CNC(=O)[C@H1]3NC(=O)O[C@H1]3C)CC2 CC[C@@](C)(F)C(=O)NC[C@@H1](O)CN(C)C(=O)C=1C=NN(C2=CC=C(F)C=C2F)C=1 CC=1C=CN([C@@H1](C)C(=O)NC[C@H1](O)CCNC(=O)C2=CC3=C(F)C=CC=C3[NH1]2)N=1 CCC1=CC(C2=CC=C(C(=O)N3CC[C@@H1](O)[C@@H1](F)C3)C=4[NH1]C=CC2=4)=CC=C1O O=C(CCC(F)F)N[C@@H1]1CC[C@](F)(CNC(=O)[C@@H1]2CCC3=NN=CN3CC2)C1 C#CC1=CC=C(OCC(=O)NC[C@H1](NC(=O)C2=C[NH1]N=C2F)C(C)(C)C)C=C1 CC[C@](C)(CO)C(=O)N1CC(C)(NC(=O)[C@H1]2CC(=O)N([C@@H1](C)C3=CC=CC=C3)C2)C1 CC1=CC=C2C=C(C(=O)N[C@@H1]3CCN(C(=O)C(F)(F)C4CC4)C[C@@H1]3C)OC2=C1 C[C@]1(C(=O)N2CC[C@@H1](C3(NC(=O)C4=COCCC4)CC3)C2)COC5=CC=CC=C51 CC[C@@H1](C#N)C(=O)N[C@H1]1CC[C@@H1](NC(=O)C=2C(C)=COC=2C3CC3)CC1 C=C1C[C@H1]2C[C@H1](NC(=O)N[C@@H1](C)C3=NC(C4CCOCC4)=N[NH1]3)C[C@@H1](C1)C2 CC(C)(C)OC(=O)NCC1=CC=C(C(=O)N2CCC[C@]23CCOC3)C=N1 CO[C@@H1]1C[C@H1](C(=O)N[C@H1]2CCCC(F)(F)C2)N(C(=O)[C@H1]3OCCC3(C)C)C1 C=C(Cl)C(C)(C)C(=O)NCC[C@H1](C)NC(=O)C[C@H1]1C(=O)NC2=CC=C(Cl)C=C21 COC(=O)[C@]1(C(=O)NCCC(C)(C)NC(=O)CC=2SC(O)=NC=2O)C[C@H1]1C CCOC(=O)[C@H1](F)C(=O)N1C[C@H1]2[C@H1](NC(=O)C=3[NH1]C=CC=3C4=CC=CC=C4)[C@H1]2C1 COC(=O)[C@@]1(C)CCN(C(=O)[C@](C)(C2CC2)N(C)C(=O)C=3N=NSC=3C)C1 CC1(C(=O)N2C[C@H1](O)C[C@H1]2CNC(=O)[C@H1](C)CC(N)=O)CCOCC1 CCCNC(=O)CCC(=O)N1CC(C)(C)C[C@H1]1CNC(=O)[C@@](C)(F)C(C)(C)F CC(C)NC(=O)C(=O)N[C@H1](CC=1C=C[NH1]N=1)C(=O)N2CCC(O)(CO)CC2 C[C@@H1]1C[C@@H1](CNC(=O)[C@H1]2CCC=CCCC2)CCN1C(=O)C3=CC(Br)=CO3 C=CCC(C)(C)C(=O)N[C@@H1]1CN(C(=O)[C@H1]2OC(=O)C3=CC=CC=C32)C[C@@H1]1C=C CN1CCO[C@H1](C(=O)NC[C@@H1]2CCN2C(=O)C3=NC(Cl)=CC(N)=C3Cl)C1=O CO[C@H1]1CC[C@@H1](C(=O)N[C@H1](C)CCN(C)C(=O)C2CCN(C(N)=O)CC2)C1 C[C@@H1]1CN(C(=O)[C@](C)(O)C2=CC=CC=C2)C[C@H1]1CN=C3C=C[NH1]C=C3 C[C@@H1]1C[C@@]1(F)C(=O)N2CCCN(C(=O)C3=N[NH1]C=C3C4=CC=NC=C4)CC2 COC1=CC=CC(Cl)=C1C(=O)N2CC(C)(NC(=O)[C@@H1]3C[C@]3(C)C(C)C)C2 C#CCCN=C(NCCNC(=O)OC)NCC1=CN=C(C2CCCC2)S1 O=C(NC12CC(NC(=O)[C@H1]3CC4CCC3CC4)(C1)C2)C5=CC=C(OCCF)C=N5 C1[C@@H1]CC[C@H1]1C(=O)N2CC(CCCCNC(=O)CC=3C=CON=3)C2C CCN(C[C@H1]1COC2=CC=CC=C2O1)C(=O)C3=CC=NC(N4CCC[C@@H1](C)C4)=C3 NC(=O)CCC(=O)N1CCC2(CC1)C[C@H1](NC(=O)C3=CC=NN=C3S)CO2 C=CCCC(=O)N[C@H1](C(=O)N1C[C@@H1](O)CC1(C)C)[C@@H1](C)CC CCOCC/C=C/C(=O)N1[C@H1]2CN(C(=O)C3=CC=NN=C3)C[C@H1]21 CCOC1CN(C(=O)CCC[C@H1](CC)NC(=O)[C@@H1]2[C@H1]3CN(C)C[C@H1]32)C1 C[C@@H1](CCC1N(C(=O)C[C@H1]2OC3=CC=CC=C3NC2=O)C1)NC(=O)C4(C)CCC4 COC[C@@]1(C(=O)N[C@@H1]2COCCC2(F)F)C=CCN1C(=O)C3=CSC(F)=C3 C#CCN(C(=O)CCCCCCNC(=O)[C@H1](C)N1C=NN=N1)C(C)C N#C[C@H1]1CCCC[C@@H1]1NC(=O)C2C[C@@H1]3CC[C@H1](C2)N3C(=O)C4=CC=C(N)C=N4 O=C(COCCF)NC[C@H1]1CN(C(=O)COC[C@@H1]2CCCO2)CC3=CC=CC=C31 CC[C@H1]1CN(CC)CCN1C(=O)CC[C@H1]2CCN(C(=O)[C@H1](COC)OC)C2 COC(=O)[C@H1]1CC[C@@]1(C)C(=O)NCCCNC(=O)[C@H1]2CCOC2 O=C(NC1=CC=C(C2OCCO2)C=C1)C3=CC=CC4=C3CNCC4 CC1=CC=C(C(=O)N[C@H1](C)C[C@@H1](C)NC(=O)C2(O)CC3(CCOCC3)C2)O1 CCCCSCC(=O)NCC[C@H1](CNC(=O)C1=CC=NC(OC)=C1F)OC CN(C(=O)C1=CN=C(N)C(O)=C1)C2CN(C(=O)[C@@H1]3C[C@@H1]3C4=CC=CC=C4)C2 COCCNC(=NCC[C@@H1]1CCN(C)C1=O)N[C@@H1](C)CCC=C(C)C CCCS(=O)(=O)CC(=O)N[C@@H1]1[C@H1]2CCN(C(=O)C3=CC=NC=C3N(C)C)C[C@H1]21 C[C@@H1]1CC[C@H1](CCC(=O)NC2CN(C(=O)CC3=CC=CC(Br)=C3F)C2)O1 C#C[C@H1](CC)NC(=O)C[C@@H1]1[C@@H1](NC(=O)C2(CCCC)CC2)C[C@H1]1O CC[C@@](C)(F)C(=O)N(C)CC(C)(C)NC(=O)C1=CC=2[NH1]C=CC=2S1 O=C(CC[C@H1]1CCCOC1)NC2(CO)CN(C(=O)C3(F)CCOCC3)C2 CC=1OC(C(=O)NC[C@@]2(CNC(=O)COCC(F)F)CC23CCC3)=CC=1Br CN(CCCCCCO)C(=O)[C@H1]1COCC[C@@H1]1C2=CC=C(F)C=C2 CC(=O)OCCCC(=O)NC12CCC(CNC(=O)[C@@H1]3[C@H1]4CCOC[C@H1]43)(CC1)OC2 CCC[C@@H1](NC(=O)[C@@H1](CN(C)C)NC(=O)CN(C)CC)C(=O)NC CC[C@H1](C(=O)N[C@H1](C)C1CCN(C(=O)CN2C=CN=N2)CC1)N3C=CC=N3 O=C(CCOCCCNC(=O)C1=CN=CC(CO)=C1)N2C[C@@H1](O)[C@@H1](CO)C2 CCN(CC)[C@@H1]1CCN([C@H1](CC2CC2)C=3N=N[NH1]N=3)C1 O=C(CCC1=CC(Cl)=CC=C1Br)NC23CC(CO)(C2)OC34CCOCC4 C[C@@H1]1C[C@@H1](CNC(=O)CC2CCSCC2)CN1C(=O)C3=NC=CC=C3F C[C@@H1](NC(=O)CCC1=CC=CN=C1Cl)C2(O)CN(C(=O)CC3=CC=NO3)C2 CCN1N=CC=C1C(=O)N[C@@H1]2C[C@H1](C(=O)N3CCN4N=CC=C4C3)C25CCC5 COC1=CC=C(NC(=O)[C@H1]2C[C@@H1]3C[C@H1]3N2S(=O)(=O)C4=CC=C(OC)C(F)=C4)C=N1 CS(=O)(=O)C1=NC=CC(N2CCC[C@@]3(CCCN(C(=O)C4=CC=CN=N4)C3)C2)=N1 CC1=CC(F)=CC=C1C(=O)N2CC(NC(=O)C[C@@H1]3CCC[C@@H1]3C)C2 CCCN(CCNC(=O)C1=C[C@@H1]2CCCCC[C@@H1]12)C3=NC(C(=O)OC)=NS3 CN(CC(F)(F)F)C1CCN([C@@H1](C(=O)NC2CC2)[C@@H1]3CCOC3)CC1 O=C([C@@H1]1[C@H1]2CC(F)(F)C[C@H1]21)N3CCN(C(=O)C4=CC5=C[NH1]C=NC5=N4)[C@@H1](CO)C3 CC1=NOC(C)=C1C(=O)NC[C@H1]2CCCN2C(=O)C(C)(C)C(C)=CC3=CC=CC=C3 COC1=CC(CCC(=O)N[C@@](C)(CNC(=O)[C@H1]2C[C@@H1]2C)C(C)C)=CC(OC)=C1 O=C(COC1=CC=CC(F)=C1)N[C@@H1]2CCCN(C(=O)C3=CC(Br)=CN=C3O)CC2 COCC1(CC(=O)N[C@@H1]2CC[C@@H1]2NC(=O)CC(C)(C)C#N)CCCC1 CN(C)CCCC(C)(C)NS(=O)(=O)C1=CC=C(C#N)C(NCC2CC3(CC3)C2)=C1 C=CC[C@]1(NC(=O)[C@@H1](COC)NC(=O)C2=CSN=C2C)CCOC1 C=CCSCC(=O)NC[C@]1(C)CCCN1C(=O)CC2=CC=C(C(F)F)C=C2 CCC1=CC(C(=O)N(CC)[C@H1]2CCCN(C(=O)C(C)(C)C3CCCC3)C2)=NC=N1 CN(C)CC1CCN([C@@H1](C(=O)NCCCF)C2=CC=CC(Cl)=C2Cl)CC1 CC[C@@H1](CC(=O)N[C@@H1]1CCN(CC2CCCC2)C1=O)CC(F)(F)F CCOCCC(=O)N1CCC(O)([C@@H1](C)NC(=O)C2CC(N3C=CC=N3)C2)CC1 CSC1=CC=CC(C(=O)N[C@H1]2C[C@H1]3CC[C@@H1]([C@@H1]2F)N3C(=O)[C@H1]4C5C[C@@H1]6C4[C@@H1]6C5)=C1 C=C(C)[C@@H1](CC(=O)NCCCCNC(=O)C[C@@H1]1CC2CCC1CC2)OCC CC1=CC=C(Cl)C=C1C(=O)NCC23CC(NC(=O)C4=CC(F)=CN=C4O)(C2)C3 CN1CCCC[C@H1]1C(=O)NCCC2(NC(=O)C3=CC=C(OCC4CC4)N=C3)CC2 CC1=NC(CC(=O)N(C)CCCCCCNC(=O)C2=NOC3=C2CCCC3)=CO1 CN1C=CN=C1SCC(=O)NC[C@H1](CO)CNC(=O)CCC2CC(F)(F)C2 COC(=O)CC(=O)N1C[C@@H1](C)[C@@H1](NC(=O)C2=NOC3=C2C[C@@H1](C(C)(C)C)CC3)C1 CC1(C(=O)N2C[C@@H1](C(=O)N[C@H1]3CCC[C@@H1](C4CC4)C3)C(F)(F)C2)CC1 CCCC(C)(C)C(=O)N[C@H1]1C[C@@](C)(NC(=O)[C@H1]2CCO[C@]3(CCOC3)C2)C1 CC=1N=CN(O)C=1C(=O)N2CC[C@@H1](NC(=O)C3(CF)CCC(F)(F)CC3)[C@H1](O)C2 CC1=CC(C)=CC(CCCN(C=O)CC2=CC=CC=C2NC(C)C)=C1 CCCN1CCC[C@@H1]1C(=O)NCCN(C(=O)C2=CC(C)=CO2)C3CCCC3 CN(C(=O)C1(C)CC1)[C@@H1]2CN(C(=O)C[C@@H1]3COC(=O)C3)CC[C@@H1]2O CNC(=O)C[C@H1]1CCN(C(=O)C2(NC(=O)[C@H1](C)S(C)(=O)=O)CC(F)(F)C2)C1 CCN1C=NC2=C(NC[C@H1][C@@H1](O)CN3C=CC=N3)[NH1]C(=NCCSCCOC)N=C21 COC1=C(Cl)C=C(C(=O)NCCNC(=O)C2=CN=C3C=C(C)C=CC3=C2)C=C1Cl CC=1N=C(CO)SC=1C(=O)NCCC2(CNC(=O)C(C)(C)[C@@H1]3CCCCO3)CC2 CC1=NC=C([C@H1](C(=O)N[C@H1](C)CCNC(=O)C2(N=[N+1]=[N-1])CC2)C(C)C)S1 C=C1CC[C@@H1]1C(=O)NCCC2(O)CCN(C(=O)C[C@@H1]3CSCCS3)CC2 CCC[C@H1]1CC[C@H1](C(=O)N2C[C@@H1]3[C@H1](C2)CN3C(=O)C4=CC=C(OC)N=C4Cl)CC1 CN1CCC[C@H1](CC(=O)N[C@H1]2[C@H1]3C[C@H1](CN(C(=O)C=4C=CSC=4)C3)[C@H1]2CO)C1 CC1=CN=CC(C)=C1C(=O)NC[C@@H1](O)C(=O)NC[C@@H1]2C[C@H1](O)CCO2 CO[C@@H1](C)C(=O)N1CCC(CC(N)=O)(NC(=O)CN2C[C@@H1]3C[C@H1]3C2)CC1 CC(=CC1CC1)C(=O)N2CCN(C(=O)[C@@H1](C)N3C=CC=C3)C[C@H1]2C4=CC=CN=C4 CN(C(=O)[C@@H1]1C[C@@H1]1C2=CC=CC=C2)[C@H1]3CCN(C(=O)C=4C=NN(CCF)C=4)C3 CC1=CC(Br)=CC=C1C(=O)N2CC[C@]3(CCCN(C4=NC=NC=C4C#N)C3)C2 CSC1=CC=C(C(=O)N[C@H1](CNC(=O)C2=CCCS2)C3=CC=C(C)C=C3)C=C1 CN1N=C(C(=O)NCCCN2CCCC2=O)C=C1C(F)F N=C1[NH1][NH1]C=C1C(=O)N[C@@H1]2CCOC[C@@H1]2C(=O)N[C@H1](CO)C3=CC=CC=N3 C[C@H1](C#N)C(=O)N[C@@H1](CNC(=O)C=C(Cl)Cl)C1=CC=C2C=CC=CC2=C1 CC1(C)OCCO[C@@H1]1C(=O)N[C@@H1]2C[C@H1](O)[C@@H1](NC(=O)C3=NC=C(F)C=C3F)C2 CCN(C(=O)C=C[S@](C)=O)C1CCC(NC(=O)[C@@H1]2CN3CCC2CC3)CC1 C[C@H1]1CCCC[C@@H1]1COC(=O)CCCC2=CC=C(Br)S2 CC1=CC([N+1](=O)[O-1])=CC(C(=O)N[C@@H1]2C[C@@H1]3C[C@H1]2N(C(=O)C45CC(C)(C4)C5)C3)=N1 CCCN1C=CC=C1C(=O)N[C@H1](CO)C(=O)NCC2=NC=CC=N2 C#C[C@@H1](CC1CC1)NC(=O)[C@H1]2COCCN(C(=O)C3=CC(C#N)=CN3C)C2 CC=CC(=O)N1CC2(C(=O)NCC[C@@]3(C)CC3(F)F)CCC1CC2 O=C(C1=NSC=C1C2=CC=CC=C2)N3CC[C@H1](CN=C4[NH1]N=CO4)C3 CC(=CC(=O)N1C[C@@H1](O)[C@H1](N(C)C(=O)CC2=C(C)C=CC=C2Cl)C1)C(F)F CCC[C@@H1](C(=O)N1CC[C@H1](OC2=CN=CC=C2CNC(=O)C3=C(Cl)CC3)C1)C(C)C CC1=NOC(C)=C1C(=O)N[C@@H1]2CN(C(=O)[C@@H1](C)C3(O)CCC3)[C@H1]4CCC[C@@H1]24 CC=1N=C(CO)SC=1C(=O)N(C)CCOCCNC(=O)C2=CCCS2 CC1=CC=C(O)C(C(=O)N2CC[C@@H1](NC(=O)[C@@H1]3C[C@@H1]4CC[C@H1]3O4)C[C@@H1](O)C2)=C1 CC1=CC=CC(C)=C1N2C=C([C@H1]CC3N(C(=O)[C@@H1](C#N)CCC4=CC=CC=C4)C3)N=N2 CCCC(=O)N[C@H1](CNC(=O)C1=NC=CC=C1OCC)C2=CC=C(C(C)C)C=C2 C=CCCOCCCCC(=O)NCCCCCNC(=O)CC[C@H1](C)N(C)C C[C@@H1](CC1=CN(C2CC2)N=N1)C(=O)N[C@@H1]3CCC4=CC=CC=C4C3=O O=C(O)[C@H1]1C(=O)NCCN1C(=O)C2(O)CCN(CC3=C(O)C=CC(Cl)=C3Cl)CC2 CC#CCCC(=O)NCC(C)(C)OCCNC(=O)C1=COCCC1 COC=1C=CSC=1C(=O)N2CCOC[C@H1](NC(=O)/C=C/C=3N=NN(C)N=3)C2 CCOC(=O)[C@@H1](F)C(=O)N1C[C@H1]2[C@H1](NC(=O)C3=CC4=C(S3)CCS(=O)(=O)C4)[C@H1]2C1 O=C(CCCC1CCCCC1)N[C@@H1]2CN(C(=O)C3CCSCC3)C[C@@H1]2F CCN(C[C@@H1](C)NC(=O)[C@H1]1C[C@H1](OC)C1)C(=O)C2=CC=CC(C3CC3)=N2 CC[C@@H1](CC(=O)N[C@@]1(C2CC2)CCN(C(=O)C3(OC)CC3)C1)C4CC4 CC1=NC=NC(N2CC(C3CN(C(=O)[C@H1]4CC5=CC=CC=C5N4C(C)C)C3)C2)=C1 CN1N=CC(C(=O)NC[C@H1]2[C@H1](N3C(=O)CN4C=CC(=O)C5=CC=CC=C54)[C@H1]2C3)=C1Br COC(=O)CCCCC(=O)N1C[C@H1]2CC[C@@H1](NC(=O)C3=CN=CC(Cl)=C3)[C@H1]2C1 CC1=CC=CC([C@H1](O)C(=O)NCC2CN(C(=O)[C@H1]3CCS(=O)(=O)N3)C2)=C1F CC1=C(C(=O)N[C@H1]2CN(C(=O)CCCN3C(=O)CNC3=O)C[C@@H1]2C)CC1 O=C(C[C@H1]1CN(C(=O)[C@]2(CO)CCOC2)CCO1)NC[C@@]34CC=C[C@@H1](C3)OC4 [N-1]=[N+1]=N[C@H1]1CC[C@@H1](C(=O)N2CCO[C@H1](CNC(=O)[C@@H1]3CNC4=CC=NN4C3)C2)C1 COC1CC(CCC(=O)N2CCC[C@]3(CCCN3C(=O)CC4=N[NH1]C(=N)S4)C2)C1 CCOC1=CN=C(C(=O)N2CC(C3CN(C(=O)[C@H1]4COC(=O)C4)C3)C2)C=N1 O=C(NC1(CNC(=O)[C@H1](O)C2=CC=CC=C2)CCC1)C3=CSN=C3C4CC4 CC[C@@H1]1CN(C(=O)C2=CC(C)=NC(O)=N2)CCN1C(=O)C3=NC4=CC=CC=C4S3 COCC1=CSC(C(=O)N[C@@H1](C)C2CN(C(=O)C3=NC=C(C(F)(F)F)S3)C2)=C1 CCOCC1(C(=O)NC[C@H1]2CN(C(=O)CS(=O)(=O)CC(C)C)CC2(C)C)CC1 CO[C@@H1]1C[C@@H1]2C[C@H1](C1)CN2C(=O)[C@@H1]3CCCN(C(=O)CCNC(N)=O)CC3 CC=1N=CSC=1C(=O)N2CCN(CCNC(=O)[C@@H1]3CCC4=NN=CN4CC3)CC2 CC[C@H1]1OCC[C@@H1]1C(=O)NC2CCN(C(=O)C3=CN=C(C4CCC4)N=C3O)CC2 COCC=CC(=O)N1CCCN(C(=O)COC2=CC=CN=C2Cl)[C@@H1](C)C1 C[C@@H1](CCCN=C1[NH1]N=C(C(F)F)O1)NC(=O)[C@H1](C)C2=CC=CC=N2 CC=1ON=CC=1C(=O)N2CCO[C@H1]3CCN(C(=O)C45CC(C4)S(=O)(=O)C5)C[C@H1]32 CC1=CN=C(C(=O)N2CC[C@@H1](O)[C@H1]2C(=O)NC3=CN=CC(C(F)F)=C3)C=N1 COCCC[C@@H1](C)C(=O)N[C@@H1]1CC[C@H1](CCC(=O)N[C@@H1]2CCC3=CC=CN=C32)C1 CCCN(CCC)CCCC(=O)N(C)[C@H1](C)CN(C)C(=O)[C@H1]1CCCC1(C)C C=CCCN1C=C(C(=O)N(C)[C@@H1](C)CN(C)C(=O)CCC2=CN=N[NH1]2)N=N1 COCC(=O)N1CC(O)([C@H1](C)NC(=O)C=CCN2C=NC=N2)C1 CC[C@@H1]1CCN(C(=O)C2(SC)CN(C(=O)C=3C=CC(=O)N(C)N=3)C2)[C@H1]1C CC=1C=C(C)N(CCCC(=O)N[C@]23CO[C@H1](C2)[C@H1](NC(=O)[C@H1]4C[C@@H1](O)C4)C3)N=1 CN1[C@H1]2CC[C@H1]1CC(C(=O)N3C4CCC3(CNC(=O)C5=C(Cl)CC5)CC4)C2 CCC1=CC=C(C(=O)NC[C@H1]2C[C@H1]2CNC(=O)C3=CC=C(COC)C(F)=C3)S1 CNC1=CC=CC(C(=O)N2CC3(C[C@@H1](C(=O)N4C[C@@H1]5CC[C@H1](C4)N5C)CO3)C2)=N1 C[C@H1](OC1=CC=C(F)C=C1Cl)C(=O)NC2(C3CN(C(=O)C(C)(F)F)C3)CC2 CCC(C)(C)OCC(=O)N1CCC2(CCN(C(=O)[C@@]3(C)CC3(C)C)CC2)[C@H1](C)C1 O=C(C=CC1=CC=CO1)N2CCN(C(=O)CN3N=NC(=O)[NH1]3)[C@@H1]4CCCC[C@H1]4C2 CC=1C=C(NC(=O)C=C2CCN(C3=NC=NC(C(F)(F)F)=C3Br)CC2)SN=1 O=C(N[C@@H1]1C[C@H1]1NC(=O)[C@@H1]2CCC23CCC3)C=4OC=C5C=4CCC5 CCN1C=C(CC(=O)N[C@H1](C)CC2CCN(C(=O)C[C@H1]3CCC3(F)F)CC2)N=N1 C#CCO[C@H1](C)C(=O)N1CCC2(CC1)CO[C@H1](CNC(=O)C3(C(C)C)CCC3)C2 CCCOCCCC(=O)N1CC[C@H1](CNC(=O)C(F)(F)C2=CC(F)=CC(F)=C2)C1 C[C@@H1]1[C@@H1](C(=O)N2C[C@H1]3C[C@H1]2C[C@@H1]3NC(=O)C4=CC=C(CF)C=C4)C1(F)F O=C(NC[C@]12CCC[C@H1]1CN(C(=O)COCC(F)F)C2)[C@H1]3CCN4N=CN=C4C3 COC1=CC(C(=O)N[C@@H1]2CC[C@H1]2NC(=O)C=3C=C(C(C)C)N(C)N=3)=CN=C1O C=C[C@H1](CC)CC(=O)N1CCN(C)C[C@@H1]1CNC(=O)C=2N=COC=2C(C)(C)C COC1=CC=C(C2=CN(CCN(C)C(=O)CC3=CC=C(F)C(C)=C3)N=N2)C=C1Cl COCC[C@]1(NC(=O)[C@@H1]2CCCCS2)CCN(C(=O)C=3C=C4N(N=3)CCC4)C1 CCOCCCN1C(N2CCC(F)(F)C2)=NN=C1[C@@]3(COC)CCCSC3 CC=1N=C(C(=O)N[C@H1](C)C2(O)CN(C(=O)[C@]34CCCC[C@@H1]3OCC4)C2)SC=1C CC(=O)CC1(C(=O)N[C@H1]2CN(C(=O)C(C)(C)CN(C)C)CC[C@@H1]2C)CCCC1 COCC[C@H1](CO)NC(=O)[C@H1]1CC=CCN1C(=O)CN2C=CC(C)=C2 CC[C@@]1(C)C[C@H1](NC(=NCC2=CC=C3C(=C2)OCO3)NCC4=CC=C(C)S4)CCO1 COCCCC(=O)N[C@@]12CCC[C@@H1](CN(C(=O)[C@@H1]3CCCCC(C)(C)C3)C1)C2 CSCC[C@H1](C(=O)N1CCN(CC(C)(C)NC(=O)[C@@H1]2C[C@@H1]2CF)CC1)N(C)C CC(C)C1=N[NH1]C=C1C(=O)N[C@@H1]2CCCN([C@@H1]3CCCN(C(C)(C)C)C3=O)CC2 C=CC[C@H1](CC(F)F)C(=O)N1CCOC[C@H1](CNC(=O)[C@H1](CO)NC(N)=O)C1 CC(C)C[C@@H1](CNC(=O)C[C@@H1]1CCC1(C)C)NC(=O)CCOC2=CC=CC(F)=C2 CC1=CC=NC=C1C(=O)N[C@H1](C)C2CCN(C3=CC=NC(C(C)C)=N3)CC2 CCCN1C=C(C(=O)N[C@@H1]2CN(C(=O)CN(C)S(N)(=O)=O)[C@@H1]3C[C@@H1]23)N=N1 C[C@H1](NC(=O)CSC1CC1)C2CN(C3=NC=NC4=C([N+1](=O)[O-1])C=CC=C34)C2 CCCN(C(=O)[C@@H1](CCC(N)=O)N(C)C)[C@@H1]1CCN(C(=O)CCSC)C1 CCC1=CON=C1CC(=O)N[C@@H1](C(=O)NC2CCN(C)CC2)C3=CC=NN3C C#CC1(O)CN(C(=O)[C@@]2(C)CN(C(=O)C=3C=CN(C)C=3)C(C)(C)C2C)C1 CCOC(=O)[C@@]1(Cl)C[C@@H1]1C(=O)N2CCC[C@@H1](N(CC)C(=O)C3CC(C)(C)C3)CC2 CN1C[C@@H1]2CC[C@H1](C1)N2C(=O)C3=CSC(NC(=O)OC(C)(C)C)=N3 CC1(C)SCC=C1[C@H1](C(=O)NCC2=CC=CC(Br)=C2)N3CCC(=CC(F)F)CC3 COC1=CC=C2C(=C1)C(=O)[C@@H1]3CN(CC4=NN(C)C=C4[N+1](=O)[O-1])CCN23 O=C(N[C@H1]1C[C@@H1](C(=O)NCCOC2=CC=NC=C2)C1)[C@H1]3C[C@H1]4O[C@@H1]3[C@@H1]5C[C@H1]45 CC(=O)N1C[C@H1](O)C[C@H1]1C(=O)N2CCC[C@@H1]2[C@H1]3CCCN3C(=O)[C@H1]4C[C@H1](O)C4 CC[C@@]1(C(=O)N[C@H1]2C[C@H1]3CC[C@@H1]([C@@H1]2F)N3C(=O)C4=CC=C(SC)O4)CCCO1 C[C@H1](CNC(=O)CCN1CCCC1)[C@@H1](F)C(=O)NC[C@]23CC[C@H1](C[C@H1]2O)C3 COC[C@@]1(NC(=O)CC2=CC=CC(F)=C2F)CCN(C(=O)C=CC3=NC=CO3)C1 COC(=O)NCCCC(=O)N1CC[C@@H1](C(=O)NC2=CN=CC(CO)=C2)[C@@H1]1C CC1=CSC2=NC=C(C(=O)N3CCN(C(=O)[C@@H1]4CNC(=O)O4)C[C@H1]3CC(F)F)N12 CCOC1=CN=C(NC2=CC=C(NC(=O)C3=C(Cl)C=CC=C3I)C=N2)N=C1 C[C@H1](OC[C@@H1]1CCCCO1)C(=O)N[C@@H1](C)CNC(=O)C2C[C@@H1](C)[C@H1](C)C2 C#CC[C@@H1](C)C(=O)N1CCCCC[C@H1](NC(=O)C2=CC=CC3=C2N=NN3C)C1 CN1CCC[C@@H1](C(=O)N2C[C@H1]3C[C@H1](NC(=O)COC[C@@H1]4CCCO4)C[C@H1]2C3)C1 C[C@H1](C(=O)N[C@H1](CCO)C1CCCC1)[C@@H1]2CCN(C(=O)CNC3=CC=CC=N3)C2 CN(CCS(N)(=O)=O)C1=NC2=CC=CN=C2C(=N[C@@H1]3CCN(C4CC4)C3)[NH1]1 C#CC[C@H1](O)C(=O)N1CC2(CCN(C(=O)C3(O)CCOCC3)CC2)C[C@H1]1C CC(C)(O)C1=CN(C[C@H1]2CCC[C@@H1](CNC(=O)C3=CC(O)=NC=C3Br)C2)N=N1 C[C@H1](CN(C)C)C(=O)N1C[C@@H1]2C[C@H1]1[C@H1]2NC(=O)C3=CC=C4C(=C3)CCC4 CC1=CC=C(C(=O)NC=2C=CSC=2C(=O)N3CCC4(CC3)CNC(=O)C4)N1C C=C1CC(C)(C(=O)NC[C@H1](C)[C@@H1](F)C(=O)N2CC[C@](O)(C(F)F)C2)C1 CC[C@@](C)(CNC(=O)[C@@](C)(CO)NC(=O)COC(C)C)COC CC1(C)CO[C@H1](CC(=O)N[C@@H1]2C[C@@H1]3CC[C@H1](C2)N3C(=O)CSC=4C=N[NH1]C=4)CO1 COCC=1C=COC=1C(=O)N2C[C@H1]3C[C@@H1](NC(=O)CN4C=NN=C4)C[C@H1]2C3 C=CCC1(C(=O)NC[C@H1]2N(C(=O)CN3N=CC=C3N)CCC2(C)C)CCCC1 CCN(CCNC(=O)C=1C=C(C(C)(C)C)[NH1]C=1C)C(=O)C2(C)CCC(OC)CC2 CCCCCCCCCC(=O)N1CC2(CCN2C(=O)CC(=O)O)C1 CCC(CC)(CNC(=O)[C@H1]1CCC1(F)F)NC(=O)C[C@@H1]2CCCC[C@H1]2O CC1=NON=C1CC(=O)N2CC(O)(C3(CNC(=O)C4(C#N)CCOCC4)CC3)C2 CC=1N=N[NH1]C=1CNC(=O)[C@@H1]2[C@H1]3CC[C@H1](C3)N2C(=O)[C@@H1](C)C(F)(F)F CC1=CC=C2OC=C(CC(=O)N[C@H1](C)[C@@H1](CO)NC(=O)C(C)C)C2=C1 CC(C)CCCC(=O)NC[C@H1](NC(=O)[C@H1](O)CC1CCOCC1)C2CCCC2 C=CCNC(=O)NC(=O)[C@@H1](C)N(C)CCCNC(=O)CCCC1=CC=CC=C1Cl CN1N=CC(I)=C1NC(=O)[C@@]23C[C@H1]2CN(CC4=CC(Br)=NC=C4F)C3 CN1N=NC(CNC(=O)[C@]2(C)CNC(=O)C2)=C1C(=O)N3CCC[C@H1]4COC[C@H1]43 CC=1C=C(C)N(CCC(=O)N[C@H1]2CCC[C@H1]2C(=O)N3CCN(C(C)C)CC3)N=1 CCCC1=NN(C)C(C(N)=O)=C1NC(=O)[C@@H1]2OCC[C@H1]2C(=O)OC CCOC(=O)[C@@H1](CC)C(=O)N(C)C[C@H1](O)CN(C)C(=O)C1=CC(OC)=CN=C1F CCNCC1[C@@H1](CN2C=CN=C2C3=CC=C(OC)C(C4=CC=NC(OC)=C4OC)=C3)C1 CC=1[NH1]C(=N)SC=1C(=O)N2C[C@@H1](NC(=O)[C@@H1]3CCC3(F)F)[C@H1](C4=CC=NN4C)C2 COCCOCC=CC(=O)N1CCC[C@@H1](NC(=O)C=2N=C(Cl)SC=2Br)C1 NC(=O)C1=CSC(CNS(=O)(=O)C2=CC=CC(=N[C@@H1]3CC[C@H1]4CC[C@H1]43)[NH1]2)=N1 C=C[C@@H1]1CC[C@H1]1C(=O)N[C@@H1]2CN(C(=O)C3=C(Cl)C=CC4=C[NH1]N=C34)CC25CC5 CN(CCNC(=O)C=CC(=O)C1=CC=CC=C1)C(=O)C2=CC=CC=3C=C[NH1]C2=3 O=C(CCC1=CC=NC(Cl)=C1)NCCC2(NC(=O)[C@@H1]3[C@H1]4CNC(=O)[C@H1]43)CCC2 CN1C=C(Br)N=C1CN2CC[C@@H1](C(=O)NC3=CC(Cl)=CC=N3)C2 COCC(COC)NC(=O)[C@@H1](CC(F)F)N(C)C(=O)C=1N=C(O)SC=1C CC1=CC=C([C@H1](CNC(=O)[C@]2(CF)CC2(F)F)NC(=O)C3=CN=C[NH1]3)C=C1 CC1=CC(CCC(=O)NC[C@H1]2CN(C(=O)C=CC(N)=O)CCC23CCOCC3)=N[NH1]1 C=CC[C@H1](C)C(=O)N1C[C@H1]2C[C@H1]1CC[C@@H1]2NC(=O)[C@]3(O)CC[C@@H1](CC)C3 COC1=CC=C(C)C(C(=O)N[C@@H1]2C[C@H1]3CN(C(=O)C4=C[NH1]C(Br)=C4)CCN3C2=O)=C1 O=C(NC[C@@H1]1CC2(CC2)CN1C(=O)[C@@H1](O)C3CCCC3)[C@H1]4CCCCC4(F)F CCC[C@H1](CCO)N[C@H1](C)C1=CC=C(S(=O)(=O)N2CCC3=CC=CN=C3C2)C=C1 CCC[C@H1]1CC[C@H1](C(=O)N2CC[C@H1](CCNC(=O)[C@H1]3C[C@]4(C)C[C@@H1]3CO4)C2)CC1 CC=CC(=O)N(C)C[C@H1]1CCCCN1C(=O)C=2C=NN(C3=CC=CC=C3Cl)C=2 CCC1=CC=CC=C1CNC(=O)[C@H1](NC(=O)[C@H1]2CCC[C@@H1]2O)[C@H1]3CCOC3 C[C@H1](CNC(=O)CCC1=CN=CC=N1)CN(C)C(=O)[C@H1]2CC3=CC=C(F)C=C32 CN(C)CC1=CC(C(=O)N[C@@H1]2CN([C@@H1]3CCN(C(C)C)C3=O)CC[C@H1]2O)=NO1 O=C(COC1=CC=CC(Cl)=C1)N[C@@H1]2CC[C@H1]2NC(=O)[C@@H1]3CC34CC(F)(F)C4 CC(C)[C@H1](NCCCCS(C)(=O)=O)C1=NN=NN1C2=CC=C(Cl)C=C2F C[C@H1](NC(=O)C1=CC=CC=2[NH1]N=CC1=2)[C@@]3(O)CCN(C(=O)C4CC(F)(F)C4)C3 COC(=O)C1=C(C)CCN(C(=O)C2=CC=NC(C(F)(F)F)=N2)C1 C[C@@H1](CCCCNC(=O)C=1N=COC=1C2=CC=C(C#N)C=C2)NC(=O)C3(O)CC3 CS[C@@H1]1CN(C(=O)[C@@]2(O)CN3CCC2CC3)C[C@H1]1NC(=O)C4=CC=CC(=O)N4C C[C@H1](NC(=O)C=1C=C2N(N=1)CCN(CC3=C(O)C=C(F)C=C3F)C2)C4=CN=C[NH1]4 CCOC(=O)[C@](C)(F)C(=O)N1CC[C@@H1](NC(=O)CC=2C=N[NH1]C=2)CC(C)(C)C1 CC1=C(C(=O)NC[C@@H1](CNC(=O)[C@H1](C)[C@H1](O)C(C)C)C2=CC=CC=C2)SCCO1 CS[C@@H1](C)CCC(=O)NCCC1(CNC(=O)[C@H1]2CCCN(C(=O)N(C)C)C2)CC1 CC[C@@H1](C(=O)N1C[C@H1]2CC[C@@H1]1[C@@H1]2NC(=O)CSC3=CC=C(O)C=C3)N4C=CC=N4 CO[C@H1]1C[C@@H1](NC(=O)C(=O)N2CC[C@@H1](C3=CC(F)=CC(F)=C3)C2)C1 CC1(C)CC(CO)(CNC(=O)CC2CCN(C(=O)[C@H1](O)CN3C=NC=N3)CC2)C1 CC=CS1C(C=CC(=O)N2CC[C@H1](CNC(=O)CCC3=NC=C[NH1]3)C[C@H1]2C(=O)OC)=N1 CCC[C@H1]1C[C@H1]1C(=O)N(C(=O)C[C@H1](CC)CC2=CC=CC=C2)C3=CC=CC=C3O O=C(CC1=CSN=N1)NC[C@]2(F)CCCN(C(=O)C3=NC4=CC=CC=C4[NH1]3)C2 CC(C)N(CCN(C)C(=O)[C@H1]1C[C@@H1]1C2CCC2)C(=O)C=CC3=COC=N3 O=C(N[C@H1]1C[C@@H1](NC(=O)[C@H1]2CC2(F)F)C1)[C@@H1]3CCCCN3C4CCCC4 O=C(NCC[C@H1]1CCN(C(=O)[C@H1]2C[C@@H1](F)C2)C1)C3=C(Cl)C=CC4=C[NH1]N=C34 CC1=CC(C)=CC(CNC(=O)CCOCCCNC(=O)C2=CC=C(O)C=N2)=C1 CC=1C=CC2=NC(C(=O)N[C@H1]3C[C@@H1](CCNC(=O)[C@H1](OC)[C@H1](C)CC)C3)=CN2C=1 C[C@H1](C(=O)N1CC[C@@](F)(CNC(=O)C2=CC3=NC=CN3C(O)=N2)C1)S(N)(=O)=O COCCC[C@@H1](C)C(=O)N1CCN(C(=O)CN2CC(=O)NC2=O)[C@H1](C)C1 C[C@@H1](CNC(=O)CC1(NC(=O)CN2CC(=O)NC2=O)CC1)[C@H1](O)CO C=CCC1(NC(=O)[C@H1]2CCCN2C=O)CCN(C(=O)CN3C(=O)CCC3=O)CC1 CC[C@H1](C)C1=CC=C([C@H1](C(=O)NCC(F)F)N2CCOC[C@](O)(CO)C2)C=C1 CCOCCCC(=O)N(CC)C[C@H1](C)NC(=O)[C@@H1]1CCCS1 CC[C@H1](NC(C)=O)C(=O)NC1(CC)CCN(C(=O)C2=CCCC[C@@H1]2C)CC1 O=C(N[C@H1]1CNC(=O)C12CC2)[C@H1]3CCN(C(=O)C4=CC=NC=C4Cl)C[C@H1]3O CC(C)C1(C(=O)N2CC[C@H1](NC(=O)[C@@]3(C)COC4=CC=CC=C4O3)C2C)CC1 CO[C@H1]1CN(C(=O)C=2C=CSN=2)CC[C@H1]1NC(=O)CC3CCC(C)(O)CC3 COC(=O)[C@@H1]1CN(C(=O)N[C@H1]2CC[C@H1](CO)C2)C[C@H1]1C(=O)OC C[C@H1](NC(=O)C1(C(C)(F)F)CC1)[C@H1]2CCN(C(=O)C3=CC=C(O)C(N)=C3)C2 CCC=1C=C(C(=O)NC[C@H1]2CN(C(=O)C3=C(Br)C=NN3C)CC24CC4)ON=1 COC1=CC(Cl)=C(Br)C=C1C(=O)NCC2(CCNC(=O)[C@@H1]3C[C@@H1]3C)CC2 CC[C@@H1]1CN([C@@H1](C(=O)NC2=CC=C(OC)C=C2)[C@H1]3[C@@H1]4COC[C@@H1]43)CC(=O)N1 COCCN1C=C(C(=O)N[C@@H1]2[C@H1]3C[C@@H1]2N(C(=O)[C@H1](C)CC4=CC=NN4C)C3)N=N1 C=CC[C@@H1](C)[C@H1](CC)NC1(C2=CC=CC=C2C(F)(F)F)CC1 CCCC(=CC(=O)NC[C@H1]1C[C@@H1](OC)CN1C(=O)C2=CC([N+1](=O)[O-1])=N[NH1]2)CCC CN1N=CC(C(=O)N2CC(F)(C(=O)N3CC(C)(C)CC[C@@H1]3CO)C2)=C1N C[C@@H1](CCC(F)(F)F)N[C@@H1]1COC2=C(C=NN2C)C1 CC=1ON=CC=1C(=O)NCC(=O)NC[C@H1](NC(=O)[C@@H1](C)C(C)C)C(C)(C)C COCCC[C@@H1](C)C(=O)N(C)C[C@@H1](O)CNC(=O)CNS(N)(=O)=O CCCC[C@H1](CNC(=O)CC1CN(C)C1)NC(=O)C2=NNC(=O)CC2 CCC[C@H1](C(=O)N1CCC(C)(C)[C@H1]1CC(=O)N[C@@H1](CO)CCF)N(C)C O=C(C[C@@H1](O)CNC(=O)[C@H1]1C[C@@H1]2CCC[C@@H1]2C1)N[C@H1]3CC=CCC3 COC1=CC(C)=C(Cl)C=C1C(=O)N2C[C@@H1](C)[C@H1](CNC(=O)C=3C=C(C)[NH1]N=3)C2 C=C[C@H1]1OCC[C@@H1]1C(=O)N(CCC(=O)N(C)CC2(C)CCC2)C3CC3 CCO[C@H1](CC)C(=O)N1CC(CNC(=O)C=2SC=CC=2Br)(C(N)=O)C1 COCCS(=O)(=O)CC(=O)N(C)CCCNC(=O)[C@H1]1CC[C@H1]1C2=CC=CC=C2Cl O=C(CN1C=C(C2=CC=NC(F)=C2)N=N1)N3C[C@H1]4C[C@H1](C5=CC=CC=C5)[C@H1]4C3 CCCCC(=O)N1CSC[C@H1]1C(=O)N[C@@H1]2C[C@@H1](C)CN(C(=O)C=3C=NSC=3C)C2 C[C@@H1](O)[C@H1](NC(N)=O)C(=O)NCCOCCN(C)C(=O)C1(F)C(C)(C)C1(C)C C=CC=C(C)C(=O)N1[C@H1](C)CC[C@@H1]1C(=O)NCC=2C=CSC=2C CC[C@H1](C(=O)NCCCCN1C=C(CCCC(C)(C)C)N=N1)[C@@H1](C)O CCCOC1=CC=C(C(=O)N2CC[C@@](O)(CNC(=O)C3=CN=CC(N)=C3)C2)C=C1 CCN1N=CC(C(=O)N2CCN(C(=O)[C@H1]3C[C@@]3(C)Br)CC4(CC4)C25CCC5)=C1C CO[C@H1](CC(C)(C)C)C(=O)NCCSCC(=O)NC[C@@H1]1CCC(C)(C)CO1 CC1=CN=C(CCC(=O)NCC2CC(NC(=O)C=3C=CC4=N[NH1]C=C4C=3F)C2)[NH1]1 CN(CCC(=O)N[C@H1](CO)CC1=CN=C[NH1]1)C(=O)[C@@H1]2C[C@@H1]3CC[C@@H1]3C2 COCC12CC(NC(=O)C34CCC(NC(=O)[C@H1](C)SC(C)C)(CC3)C4)(CO1)C2 O=C(CCOCC1CC1)N[C@@H1]2C[C@@]3(NC(=O)C4=CC=CC=5N=N[NH1]C4=5)CO[C@@H1]2C3 CN1N=NC(C(=O)N2CCO[C@@H1](CC3=CN(CCN4CCCC4)N=N3)C2)=N1 CC1=CC=C(Br)C(CCC(=O)N(C)CCCCNC(=O)C2CCCC2)=C1 C[C@@H1]1C[C@H1](C(=O)NCCF)CN(C(=O)CCCOC(C)(C)C)C1 CCC1=NC(Cl)=C(F)C(=N[C@H1]2C[C@](F)(CNC(=O)C3CC(C(C)C)C3)C2)[NH1]1 CSCC1=CC=C(CNC=2[NH1]C(=N[C@@H1](C)[C@@H1](C)CO)N=C3SC=CC=23)C=C1 C[C@H1](CNC(=O)C1(C#N)CCCCC1)C(=O)NC2=CSN=C2C3CC3 COC1=CC=CC2=C1NC[C@H1]2NC(=O)[C@@H1](NC(C)C)C3CCCC3 C[C@H1](CN1CC(=O)N(C[C@]23CCC[C@H1]2OCC3)C1=O)CN(C)C COC(=O)C1(CC(=O)NC2(C)CN(C(=O)C=3C=NN(C[C@@H1]4CCOC4)C=3)C2)CC1 COCC1(C(=O)NC[C@@H1](C)CNC(=O)CNC(=O)C2=CC=C(F)C=C2)CC=CC1 C=C=C[C@@H1](C)C(=O)N1CCC(C(C)(C)NC(=O)C[C@@H1](C(F)F)C(C)(C)C)CC1 CC(C)C1=NC=CC(N2CCC[C@H1]2CCCNC(=O)CN3C=NN=N3)=N1 CCC1(C(=O)OC)CN(C(=O)[C@@H1]2CCN(C(=O)CCCN=[N+1]=[N-1])C23CCC3)C1 C[C@@H1](NC(N)=O)C(=O)NCCCN1CC[C@@H1](NC(=O)CCC2=NC=C[NH1]2)C1 C=CCCC[C@@H1](NC(=O)C1=CC=CC=[N+1]1[O-1])C(=O)N[C@@H1]2[C@H1]3CC[C@H1]4[C@@H1](C3)C[C@H1]42 C=CC=CCC(=O)N1CCC[C@@H1]1C2(NC(=O)CN3C=C(Br)C(C)=N3)CC2 O=C(NC1=CC=C2C(=C1)CN(C(=O)C=3C=CSC=3)C2)C4=CC=C(Cl)C=C4F CC1=CC(C(=O)N(C)CCCCN(C)C(=O)C=2[NH1]N=CC=2C#N)=NC=C1C(F)F CC1=CC=C(C(=O)NC[C@@H1](NC(=O)C2=CC=NN2CC3CC3)C(C)(C)C)C(C)=N1 CCCCOCCNC(=O)[C@@H1](C)[C@H1]1CCN(C(=O)C=2C=CC(=O)N(C)N=2)C1 CN1C=NC=C(C(=O)N[C@@H1]2CN(C(=O)[C@@]3(Br)CC34CCC4)C[C@@H1]2O)C1=O COC(=O)[C@H1](OC)C(=O)N(C)CCCNC(=O)[C@@H1]1CC(=O)N[C@H1](C=2C=NN(C)C=2)C1 COC1CC(CCC(=O)N2CC3(CCC[C@H1]3NC(=O)C(=O)C(C)(C)C)C2)C1 CCCN(C(=O)C1CC=CC1)[C@H1]2CCN(C(=O)C3=CC=NC(NC(C)=O)=C3)C2 CNC1=CC=C(C(=O)N2CCN(C(=O)C=3SC(C)=NC=3C)[C@H1](C4CCCC4)C2)O1 COC1=CC(CCC(=O)NCC2(F)CN(C(=O)CC=3[NH1]C=NC=3C)C2)=CC=C1O O=C(C1=CC=CC2=C1SCCC2)N3CCC[C@](F)(CNC(=O)C45CCC4CC5)C3 C#CCCC(=O)N[C@@H1]1C[C@H1]1NC(=O)C[C@H1](O)C2=CC=CC(F)=C2 C[C@@H1]1CC[C@@H1](CCC(=O)NC[C@H1]2CCCCN2C3=NC=C(C(C)(C)O)C=N3)O1 CN1C=C([C@H1](NC(=O)C=2C=NSN=2)C(=O)NCCN3C(=O)CCC3=O)N=N1 N#CC1=CC=CC([N+1](=O)[O-1])=C1N[C@@H1]2C[C@H1]3CN(C(=O)CC[C@H1]4CCC(=O)N4)C[C@@H1]32 CCN1C=CC(CC(=O)NCCN(C(=O)[C@H1]2C[C@]23CCOC3)C4CCCCC4)=N1 COCCSCCNC(=O)C1=CCN(C(=O)C2=NC(C)=C(C)S2)CC1 C[C@@H1]1C[C@@H1](NC(=O)[C@H1]2C[C@@H1](O)CN2C)CN(C(=O)C3=CC=4OC=CC=4[NH1]3)C1 CCC=1C(C(=O)N2C[C@@H1]3C[C@H1]2CN3C(=O)C=4C=C(COC)[NH1]N=4)=CSC=1C CC1=CC=C(O)C=C1NC(=O)[C@H1](F)C2(O)CN(C(=O)C3=CN(C)N=N3)C2 N#CC[C@H1]1CC[C@@H1](C(=O)N(C2=C(F)C=CC=C2F)C3CCCCC3)N1 CC(C)(C)[C@@H1](CNC(=O)C1=CSC(Cl)=N1)C(=O)NC2CCC3(CCC3)CC2 C#CC[C@H1](CNC(=NCCCC)NCC12CCOC(C)(C1)C2)C3CC3 CC=CC(=O)N(C)CCCC(=O)N[C@@H1](CCO)CC(C)C C=C1CCN(C(=O)C2=CN(CCNC(=O)[C@@H1](SC)C(C)C)N=N2)C1 C[C@@H1](CNC(=O)[C@H1]1CCC2(CC2)N1C(=O)[C@H1]3C[C@H1]4CC(=O)[C@@H1]3C4)CC(F)(F)F CC(=CC1=CC=CO1)C(=O)N[C@@H1](CO)CNC(=O)C2=CC(C)=C(C)C=C2Br CC=CC(=O)N(C)C[C@H1](O)CN(C)C(=O)C1=CC=C(C2=CC=CS2)C=N1 CCCC(=O)N1C[C@@H1]2C(CNC(=O)CN3C=CC(=O)C([N+1](=O)[O-1])=C3)[C@H1]2C1 CCSCC[C@@H1](C)N1C[C@H1]2[C@@H1](C1)[C@@H1]2C(=O)N(CC=3C=COC=3)CC(C)C CCN1N=C(Br)C(C(=O)NC2(C)CCC(NC(=O)[C@H1]3CCCS3)CC2)=N1 CC1(C)C[C@@H1](CNC(=O)CCC2=CN=CC(O)=C2)CN1C(=O)[C@@H1]3CC3(Cl)Cl CC=1C=C(C(=O)NC/C=C/CC(=O)N2CC[C@]3(COC(=O)N3)C2)N(C)N=1 CN(C)NC(=O)CCC(=O)N1C[C@H1](NC(=O)CN2N=NC(C3CC3)=N2)C(C)(C)C1 C[C@]1(O)C[C@@H1](C(=O)N2[C@H1]3CC[C@@H1]2C[C@H1](CNC(=O)[C@@H1]4C[C@H1]4CF)C3)C1 CCC(CC)[C@H1](C)C(=O)N1CC[C@H1](C)[C@@H1](CNC(=O)[C@@](C)(O)COC)C1 COC[C@H1](OC)C(=O)NC[C@@H1]1C[C@H1](F)CN1C(=O)CCN2CCCCC2 COC1=CSC(C(=O)NC[C@H1]2[C@@H1]3CN(C(=O)CCC4=NC=CN4C)C[C@H1]23)=C1OC O=C(C=1C=CC2=N[NH1]C=C2C=1Cl)N3CC[C@@H1](F)[C@@H1](NC(=O)C4CCC4)C3 O=C(N[C@@H1]1CCN(C2=NC=NC3=C2COC3)C1)C4=CC=C5OC(=O)OC5=C4 O=C(CN1C=CC=N1)N2CC[C@H1]([C@H1]3CCCN3C(=O)C4=CC=NC(Cl)=C4Cl)C2 CC[C@@H1](CNC(=O)[C@@H1]1C[C@H1]1C#N)NC(=O)CCC2=CC=C3C(=C2)OCO3 CC1=NC(C(=O)N2C[C@H1](NC(=O)[C@H1](C3CC3)N4CCOCC4)C[C@@H1]2C)=CS1 CO[C@H1](CNC(=O)C(F)(F)[C@H1](C)O)CC(=O)N[C@@H1]1CCC1(C)C CC[C@@H1](N[C@H1](C1=NN=NN1C(C)(C)C)C2(N3C=C(Br)C=N3)CC2)C4=CC=CN=C4 C[C@@H1](CCNC(=O)C1=COC(N(C)C)=N1)CCNC(=O)C2CCC(O)CC2 C#CCN(C(=O)[C@H1](C)CNC(=O)C1=CN=C(O)C=C1C)[C@H1]2CCOC2 C=CC[C@@H1](C)C(=O)NC[C@@H1](O)CN(C)C(=O)C1=CN=CC(SCC)=N1 COC(=O)N1CCC(NC(=O)C2=COC(SC)=C2)CC1 COC1=NC=NC(C)=C1NC(=O)C2=CSC(CNC(=O)[C@@H1](C)N3CCCCC3)=C2 CC(C)C[C@H1](CN=C1N=C(C(F)(F)F)[NH1]S1)NC(=O)CN2[C@@H1](C)CC[C@@H1]2C CC(C)CC[C@H1](F)C(=O)NC[C@H1](C)N(C)C(=O)C1=NC(=O)N(C)[NH1]1 COCCCOCC(=O)NCC[C@H1]1CN(C(=O)CN(C)S(N)(=O)=O)CCCO1 CCOCC(=O)N1CC(C)(C)C[C@H1]1CNC(=O)CN2C=CC=C([N+1](=O)[O-1])C2=O C=C1CC[C@@H1]1C(=O)N[C@H1]2C[C@](C)(NC(=O)C3=CC=CC([C@@H1]4CCOC4)=C3)C2 CCC1=NOC(CC)=C1CNC(=NCCCCl)NC[C@@H1]2CCCN(C(C)=O)C2 C[C@@](CNC(=O)C1=CC2=CC=CC=C2C=N1)(NC(=O)C=C3CCCCC3)C4CC4 C[C@H1](CC(=O)NCCCCCCC(=O)N1CC[C@H1](CCO)C1)N2C=CN=C2 C[C@H1](C1=CN(C2=CC=C(N)C=C2)N=N1)N(C)C(=O)C3=NO[C@H1](C4=CC=CC=C4)C3 COCC1=CC=C(C(=O)NC[C@@H1]2CCN(C(=O)/C=C/C=3C(C)=NN(C)C=3Cl)C2)S1 COC[C@H1](C)C(=O)NCCCN(C)CCCNC(=O)C[C@@H1]1CC=CCN1C CC[C@](C)(CN(C)C1=NC2=C(C(N3CC[C@H1](C#N)C3)=N1)C[C@@H1](C)CC2)OC CC[C@H1](C)CC[C@H1](O)CC(=O)NCCCN(C)C(=O)CC(F)F CC1=CC(C(=O)N[C@]2(C3=CC=CC=C3)CCN(C(=O)[C@@H1](C)O)C2)=CC(C)=N1 CCC[C@H1](CC)CCC(=O)N1[C@H1](C(=O)N2CCN3C[C@@H1](C)C[C@@H1]3C2)CC[C@H1]1C(C)C COCCC(C)(C)NC(=O)CC1(NC(=O)[C@@H1](C)[C@@H1](O)CC(C)C)CCCCC1 CNC1=CC=CC(C(=O)N(C)CC(C)(C)C(=O)N2C[C@H1]3[C@@H1](C2)C3(C)C)=N1 CN1C=NC=C1C(=O)C(=O)N2CCN(C(=O)C3=CC=C4N=C(O)OC4=C3)[C@H1]5C[C@@H1]52 CCCC(C)=CC(=O)N1CCN(C(=O)CCC2=CC(Cl)=NO2)[C@H1](CC(C)(C)C)C1 CC#CCCC(=O)N1CCC(CCOC)(C(=O)N2CCC[C@@H1](CC(N)=O)C2)CC1 [N-1]=[N+1]=NC1(C(=O)NC[C@H1]2C[C@@H1]2NC(=O)C3=CC=C(F)C(Cl)=C3F)CC1 COC[C@]1(C(=O)N2CC[C@H1](OC)[C@H1](F)C2)C=CCN1C(=O)C=3C=NN(C)C=3 C=C(F)C1(CC(=O)N2CC[C@H1](CO)[C@H1](NC(=O)C34CCN(CC3)C4)C2)CCC1 COCC1=NC(C)=CC(N2CC[C@@](CF)(NC(=O)C3(F)CCCCC3)C2)=N1 C[C@@H1](CCC1CCCC1)NC(=O)[C@@H1](N2C=C(CNC(=O)C(F)(F)F)N=N2)C(C)(C)C C[C@@H1](C(=O)N1CC[C@H1]1CNC(=O)C=2OC=CC=2Cl)C3=CC=C(Cl)C=C3 CO[C@H1](C)C(=O)N[C@@H1](CNC(=O)CC(C)(C)COC(C)=O)C1=CC=CC=C1 C[C@H1]1CCN(C(=O)C2=CC=C(C3=CC=CC=C3)N=C2O)C[C@@H1]1C(=O)O CC[C@H1]1CN(C(=O)C=2C=NN3C=CC(C)=NC=23)CC[C@@H1]1NC(=O)C4=CC=NN=C4 CC1=CC=C2C(=C1)S[C@@H1](C(=O)N[C@@H1]3CN(C(=O)CCC4=CN=CC=N4)C[C@H1]3C)C2 C[C@H1](NC(=O)C1=CC(F)=CC(F)=C1)[C@@H1]2CCN(C(=O)C3=CC=CN4C=NC=C34)C2 CC1=NN=C(CC(=O)N2CCC[C@H1](CNC(=O)CN=C3C=C[NH1]C=C3)C2)O1 CN(CP(C)(C)=O)[C@H1](C(=O)NCC1=CC=CC=C1Br)C2=CN=C3C(=C2)CCOC3 C#CC[C@@H1](C)N(C)C(=O)C1=C(CNC(=O)[C@@H1](CC)CCCCC)N=NN1C CC1=CC(C)=C(C(=O)N2CCN(C(=O)[C@H1]3C[C@]34CC4(F)F)C5(CCC5)C2)C(=O)O1 CO[C@@H1](CN(C)C(=O)[C@H1](C1=CC=C(Cl)C=C1)N2CCOCC2)C(C)C COC1=CC=C(C(=O)N[C@@]2(CO)CCCN([C@@H1](C)C3=NC(C)=NO3)C2)C=C1 CC[C@@H1](C)CC(=O)N1CC[C@@H1]2CCN(C(=O)C3=CCC(C)(C)CC3)C[C@@H1]21 CCC[C@@H1](C(=O)N1CC[C@](N=[N+1]=[N-1])(C(=O)NCC23CCN(CC2)C3)C1)C(C)C CO[C@H1]1C[C@@H1](CC(=O)N[C@@]23CC[C@@H1](CN(C(=O)CC=4C=C(C)[NH1]N=4)C2)C3)C1 CCC1=CC=CC(C)=C1NC(=O)[C@@H1](C2=NC(C(F)(F)F)=N[NH1]2)N(C)C[C@H1](F)Cl CCC[C@@H1](C)N(C)CCC(=O)N1C[C@H1]2C[C@@]2(NC(=O)C=3SC(C4CC4)=NC=3C)C1 CCN(CCCNC(=O)CCCC1CCCCC1)C(=O)CC[C@@H1]2CCCC(=O)N2 CC[C@H1](NC(=O)[C@@H1]1[C@H1]2C=C[C@@H1](C2)[C@@H1]1C)C(=O)N[C@@H1]3CCOC3=O C[C@@H1]1C[C@@]1(C)C(=O)N2CCO[C@]3(CC[C@@H1](NC(=O)C4=NN(C)C5=C4CCC5)C3)C2 C[C@@H1](O)CNS(=O)(=O)C1=C[NH1]C(C(=O)N2CC[C@H1](NC(=O)C3(CO)CCC3)C2)=C1 C#C[C@H1](CCC)NC(=O)[C@H1]1CCN(C(=O)[C@@]2(C)CCCCO2)C[C@H1]1O CCN1C=C([C@H1](NC(C)(C)COC(C)C)C2=NN=NN2C3CCC3)N=N1 CC=1ON=CC=1C(=O)NCCN(CC2=CC=CC(Cl)=C2)C(=O)C[C@@H1]3CCO[C@H1]3C O=C(NC1CC2(C1)CN(C(=O)C3=CN4C(=N3)SCC4)C2)[C@@H1](O)C5CCCC5 CC(C)OC1=CC=CC=C1C(=O)N2C[C@H1](CNC(=O)[C@H1](C)N(C)C)C3(CCC3)C2 CN(C[C@@H1](O)CC1CCC1)C(=O)C=2C=C(CNC(=O)C[C@@H1]3CC(=O)NC3=O)[NH1]N=2 CO[C@H1](C)CN(C)C(=O)C1=CCCN(C(=O)CCOC2COC2)C1 CC[C@@H1]1CN(C(=O)C2=CC(C3CC3)=CS2)C[C@@H1]1NC(=O)C4CC(CC5CC5)C4 CC1=CC(O)=NC(C(=O)NCCO[C@H1]2CCN(C(=O)C3=CSC=C3C(F)F)C2)=C1 C[C@@H1]1CCN(C(=O)CC2=CN(C)N=N2)[C@@H1]1C(=O)NCC(C)(C)N(C)C CCC1=NO[C@H1](C(=O)N2C[C@H1]3C[C@H1](O)[C@@H1]2[C@@H1]3NC(=O)C=C4SCC(=O)N4C)C1 CC1=CN=CC(C(=O)N2CCC[C@H1]2[C@@H1](C)NC(=O)[C@H1]3CCCC(=O)N3)=C1C CN1N=C(C(=O)O)C=C1CNS(=O)(=O)CCC=CC2=CC=CC=C2 CCC1=C(OC)C=CC=C1C(=O)N[C@H1]2COC[C@H1]2NC(=O)C3=CC(C#N)=CN3C COCCN(CCNC(=O)CCCC1=C(F)C=CC=C1F)C(=O)[C@H1](C)CC(N)=O COCCN(C(=O)C1=CSC(SC)=N1)C2CCN(C(=O)[C@]3(OC)CCSC3)CC2 C=CC[C@@H1](CC(C)C)C(=O)N1CC[C@H1](C(=O)N(C)CC2=NC=C[NH1]2)[C@H1](C)C1 CC(C)=C[C@H1]1[C@H1](NC(=O)OC(C)(C)C)CCCN1C(=O)NCC(C)(C)C#N O=C(NCC1=CN=CC=N1)[C@H1]2C[C@H1]2C(=O)NC3=CC(CO)=CC=C3F CC(C)(CNC(=NC[C@@H1]1CCC=CCCC1)NCCN2CCOCC2)C(F)F CCSC[C@H1](NC(=O)[C@H1]1CC(C2CC2)=NO1)C(=O)N3C[C@@H1]4C[C@H1]3C[S@@]4=O N#CC1=CC=C(C(=O)N(CCC(=O)N2CC3(CO)CCC2CC3)C4CC4)C=C1 CCC1=C[NH1]C=C1C(=O)N[C@H1]2CCCC[C@H1]2C(=O)NCC3=CC(C)=NS3 C[C@@H1]1CN(C(=O)CC(F)(F)F)CC[C@H1]1N(C)C(=O)C2=CC=C3C(=C2)NC(=O)NC3 CCN1CCOC[C@H1]1CC(=O)N2C[C@@H1]3C[C@H1](C2)CN3C(=O)C4=CN=C(OC)N=C4 CC(C)(C)C(=O)NCC(=O)N1CC(C[C@H1](F)C(=O)NCC#CCCO)C1 CC[C@@H1](C)OCC(=O)N[C@H1]1CN(C(=O)C(C)(C)CC(=O)OC)C[C@H1]1CC C#CCN1CCC[C@H1]1C(=O)NC[C@@H1]2CCN(CC3=NC=C(C4CC4)O3)C2 COC1=CC=CC(CN2C[C@@H1](O)[C@H1](NC(=O)CCSC3=NC=CN3C)C2)=C1 C=CCCO[C@H1](C)C(=O)N1CC[C@]2(C=C(C(=O)NC[C@H1]3C[C@H1]4C=C[C@@H1]3O4)C2)C1 CC(C)COCCC(=O)N[C@@H1](C)[C@@H1]1CN(C(=O)/C=C/C2=CN=CC(O)=C2)CCO1 C[C@H1](C(=O)N[C@@]12CC[C@@H1](C[C@H1]1N3C=C(CO)N=N3)C2)C4=CC=CC=C4 CC(=O)N1CC[C@@H1](N(C)C(=O)CC[C@@H1](NC(=O)CC(F)(F)C(F)F)C(C)C)C1 CCCOCCC(=O)N1CC(=O)C[C@@H1]1C(=O)NC[C@](C)(CC)OC COC(=O)CCN1N=C(C)C(NC(=O)[C@H1](N)CN2C=C(Cl)C3=CC=CN=C32)=C1C C[C@H1](C1=CN(C[C@]2(C#N)CCN(C(=O)[C@@H1](F)OC(F)(F)F)C2)N=N1)N(C)C CN(CCCNC(=O)NC1=CC=C(Cl)C=C1)S(=O)(=O)N2CCCC[C@H1]2CO C[C@@H1](NC(=O)C1CCC(CC2=CC=CC=C2)CC1)C3=CC=C(Cl)C=C3 NS(=O)(=O)C1=C[NH1]C(C(=O)N2CCC(=CC3=CC=CC=C3Cl)CC2)=C1 O=C(N[C@H1]1C[C@@H1](CO)N(C(=O)C=2C=NN3C=2NCCC3)C1)[C@@H1]4C(Cl)(Cl)C45CC5 C#CC(C)(C)C(=O)N(C)C[C@H1]1[C@@H1]2CN(C(=O)C3CN(S(C)(=O)=O)C3)C[C@H1]12 CC(C)CC1=NC=C(C(=O)N2CC[C@H1](CN(C)C(=O)CP(C)(C)=O)C2)S1 CC(C)C1=CC=C(N2C=C(C3=CC(=NC(=O)[C@@H1]4CCCN4C=O)C=C[NH1]3)N=N2)C=C1 O=C(N[C@H1]1C[C@H1]1CNC(=O)C=2C=C(Cl)ON=2)C3=CC(Br)=CC=C3F CC(C)SCC(=O)NC[C@@H1]1[C@@H1](C2CC2)CCN1C(=O)[C@@H1](C)OC3CCCC3 CCOC1(C(=O)NC[C@@H1](CC(=O)NC[C@H1](C)C(C)(F)F)OC)CC1 C=CC[C@H1](CNC(=O)[C@H1](C)N1CCC2=CC=CC=C21)NC(=O)C=CC=CC C[C@@H1]1C[C@@H1](CNC(=O)C2=CC=CS2)CN1C(=O)C3=CC=C(COC(F)(F)F)C=C3 O=C(NC[C@@H1]1CCCOC1)C2CC3(C2)CN(C(=O)C4=N[NH1]C5=C(F)C=CC=C45)C3 CSC1=CC=C(C(=O)N2CC[C@@H1]2CNC(=O)CCP(C)(C)=O)S1 COC1=CC(Cl)=C(C)C=C1C(=O)N2C[C@H1](F)[C@@H1](N(C)C(=O)C=3C=CSN=3)C2 CC[C@@H1]1OCC[C@H1]1NC(=O)C2(N(C(=O)[C@@H1]3CC=C(C)CC3)C4CC4)CCC2 CC[C@@H1](NS(=O)(=O)C1=CC=CN=C1NC[C@H1](CC(C)C)OC)C2=NC(C)=CS2 CCOC(=O)[C@H1]1CCCCN1C(=O)C2=CC=CC(N=C3C=C[NH1]C=C3)=C2O CCCC(=O)N1CCC[C@@H1]1C(=O)N2CCN(C(=O)[C@H1]3COCCN3C)C[C@H1](O)C2 CN(CC1(O)CN(C(=O)[C@]2(C)C[C@@H1](O)CN2C)C1)C(=O)CC3=C(Cl)C=NN3C CC1=C(C)C[C@](C)(C(=O)NCC[C@@H1]2CCCN(C3=CC=CC=C3[N+1](=O)[O-1])CC2)CC1 CCO[C@H1](C(=O)NCC1=CC(C(=O)N2CCO[C@@H1](C)C2)=CC=N1)C(C)C O=C(C=C[C@H1]1CCCO1)NC2CC3(CCN(C(=O)[C@H1]4CCC5(CCC5)O4)CC3)C2 COC1=N[NH1]C(C(=O)N2C[C@@]3(NC(=O)[C@@H1]4C[C@H1]4OC)CC[C@H1]2C3)=C1Cl CO[C@@H1](C(=O)N1CC(C2CN(C(=O)C3=CC=CC=C3Cl)C2)C1)[C@@H1]4CCOC4 CC1=NN(C)N=C1C(=O)NC[C@@]2(C)CCN(C(=O)C3=CC(C#N)=C[NH1]3)C2 COC(=O)[C@@H1]1[C@H1](CC(=O)N2C[C@@H1](C)[C@H1](CCNC(=O)C(C)(C)N(C)C)C2)C1(C)C CO[C@H1]1C[C@]2(C(=O)N3C[C@@H1]4CC[C@H1](C3)N4C(=O)CC5CN(C)C5)C[C@H1]12 CSC1=NC=CC(=NC2CN(C(=O)CC3=C(C)N=C(O)N=C3C)C2)[NH1]1 CC(C)(C)CC(=O)N1CCOC[C@]12COCCN(C(=O)C3(CF)CCOCC3)C2 O=C(CCCC1CC1)NC2[C@H1]3C[C@H1]2CN(C(=O)C[C@@H1]4CCCOC4)C3 CCC[C@H1](NC(=O)C1=C(CNC(=O)C=2N=NSC=2N)C=NN1C)C(=O)N(C)C C=CC1(CC(=O)N2CC[C@@H1](COC)C2)CN(C(=O)[C@H1]3[C@H1]4CC[C@@H1](C4)[C@H1]3C)C1 COC[C@@H1]1CC[C@H1](C(=O)N(C)[C@H1](C)CNC(=O)C(C)(C)C=2C=NN(C)C=2)C1 COCC1=CSC(C(=O)N2CC[C@H1](CNC(=O)[C@H1]3CCN3S(C)(=O)=O)C[C@H1]2C)=C1 C#CCCN(C)CC(=O)NC[C@@H1]1CN(C(=O)C2=NC(C)=CC=C2F)C3(CCC3)C1 O=C([C@@H1]1CCCSC1)N2CC[C@@]3(CCCCN(C(=O)[C@@H1](F)C4CCOCC4)C3)C2 CC1=NSC(C)=C1CN2CC([C@H1](C)NC(=O)[C@@H1]3C[C@@]34CCO[C@H1](C)C4)C2 CC1=C(C)C[C@H1](C(=O)N(C)CCCCC(=O)N[C@H1]2CCS(=O)(=O)C2)CC1 CC1=NN(C)C=C1CN2CCC[C@@H1]([C@H1](C)NC(=O)CCN3CCCCC3)C2 CN(C(=O)[C@@H1]1CC12CCOCC2)[C@@H1](C(=O)NCC3=NOCC3)C4CC4 NS(=O)(=O)C1=CC(C(=O)N[C@@H1]2CN(C(=O)C(=O)C(F)(F)F)CC3(CC3)C2)=CO1 O=C(NC1=NC(C2=CC=C(OC3CCC3)N=C2)=CS1)C4=CCCCO4 COC1(C(=O)NCC[C@H1]2CCN(C(=O)CCCSC)[C@H1](C)C2)CCCCC1 CCN(C(=O)C=1C=CC(=NCC2CC2)[NH1]C=1)[C@H1](C)CNC(=O)[C@H1](C)C(C)(C)C COC1=NC=C(C(=O)N2CCC[C@H1]2CCNC(=O)[C@@H1](O)CC(N)=O)C(C(F)F)=N1 CC=1C=C(C(=O)N(C)[C@H1]2CN(C(=O)C[C@H1]3CCC(=O)O3)C[C@H1]2F)N(C)N=1 C[C@]1(CO)CCN(C(=O)CSCCNC(=O)C2=CN=C3N2CCC3)C1 COCCN1C=CC=C(C(=O)NCCC2=CN([C@@H1](C)C3=CN=NN3C)N=N2)C1=O CN1C(=O)[C@H1]2C[C@H1]1CCN2C(=O)NC3=NC=CC=C3Br CCO[C@H1](C)CCC(=O)N1CC[C@@](F)(C(=O)NC(C)(C)[C@@H1]2CCOC2)C1 CC[C@@H1](C(=O)N1CC2(CCC[C@@H1]2NC(=O)[C@H1]3CCCOCC3)C1)C(C)(F)F CCO[C@H1](CN[C@@H1](C(C)C)C(F)(F)F)COCC CCOC1=CC=CC=C1NC(=O)N2CCC[C@@H1](C(=O)N3CC=CC3)CC2 CS(C)(=O)=NCC(=O)N1C[C@@H1](O)C[C@@H1](NC(=O)C2=CN=CC(Cl)=C2Cl)C1 COC(=O)[C@@]1(C(=O)NCCC[C@@H1](C)NC(=O)C2=N[NH1]C3=C2CCCCC3)C[C@@H1]1C C[C@H1](NC(=O)C1CC(O)(CNC(=O)C2=CC([N+1](=O)[O-1])=C[NH1]2)C1)C3CCCC3 O=C(CCN1C=C(C2=CC=CC(O)=C2)N=N1)NCCCC3=CN=CC(F)=C3 CS[C@H1](C(=O)NCC1=CCCN(C(=O)CC2=CC=C(N)C=C2)C1)C(C)C C=CC1(O)CN(C(=O)C[C@H1]2[C@H1]3CCC[C@H1]3N2C(=O)[C@]4(C)CC=CCC4)C1 COCCC1(NC(=O)CC[C@@H1](C)NC(=O)C=2C=CN(C(F)F)N=2)CCCC1 CCCCOC1=CC=C(OC)C=C1N[C@@H1](C)C2=CC([N+1](=O)[O-1])=CC=C2OC CC(C)(C)N1N=CC(C(=O)NCCNC(=O)[C@H1]2C[C@@H1]3CCC[C@@H1]3C2)=C1N CC(C)N1C=C(C(=O)NC2=CC=CC(NC(=O)[C@]34CCCC[C@H1]3C4)=C2)N=N1 CCOC1CC(CC(=O)NCC2(F)CN(C(=O)C3=NC=CC=C3NCC)C2)C1 C[C@@H1](CNC(=O)C1=NC=CN1C(C)C)NC(=O)CN2C=CN=C2C3=CC=CC=C3 COC1=CC=C(C(=O)COC(=O)CCC[C@H1]2CCCC(=O)N2)C=C1Br CCN1N=C2C(=C1C(=O)N3CC[C@H1](C)[C@@H1](NC(=O)[C@H1](CC(C)C)OC)C3)CCC2 O=C(N[C@H1]1CCN(C2=CC=C(Cl)C=C2Cl)C1)N[C@H1]3CCC4(C3)OCCO4 CC1=C(C(=O)N2CC(CCNC(=O)[C@@H1](C)[C@@H1](O)C(C)C)C2)C=CC3=N[NH1]C=C13 CN(CC1CCCCC1)C(=O)[C@H1]2OCCOC23CCC3 CN(CC1=CC=CC=N1)C(=O)N[C@@H1]2CCCN(C(=O)OC(C)(C)C)C2 COC[C@@H1](C(=O)N[C@@H1](CC1=CC=CO1)C(=O)N2C[C@H1]3CC=C[C@@H1](C3)C2)N(C)C CCSC1(C(=O)NCCC2(CNC(=O)CC3=CC=CC(F)=C3OC)CC2)CC1 CC(C)N1CCO[C@H1](C(=O)N2CC[C@@H1](C3(NC(=O)C4=C[NH1]C=C4Br)CC3)C2)C1 CCC[C@@H1](NC(=O)CC1(C)CCOCC1)C(=O)NCC2=CC=CC(Cl)=N2 CC[C@@H1](C(=O)N1CC(C2(NC(=O)C3=CC4=C(O)C=CC=C4[NH1]3)CC2)C1)C(C)C CCC1=NO[C@H1](CC(=O)N(C)CCCCCC(=O)NCC2=NC=CN2C)C1 C[C@H1]1CCC[C@@H1](C)N1C(=O)[C@@H1]2CCC[C@@H1]2NS(=O)(=O)C3=CN=CC=C3Cl COC(=O)C1=CC=C(C(=O)NC2CCN(C(=O)CN3N=CC(O)=NC3=O)CC2)[NH1]1 O=C(C[C@@H1]1C=CCCC1)N2CCOC[C@H1]2C3=CN(C4=CC=CC(Cl)=C4Cl)N=N3 CCCCC[C@@H1](C)CC(=O)N[C@@H1]1C[C@@H1]2CC[C@H1](C1)N2C(=O)[C@@H1]3C=C3C CC(C)S(=O)(=O)CC(=O)N(C)[C@H1]1CCN(C(=O)C2=C[NH1]C(Br)=C2)C1 CC(C)(CNC(=O)C1=CC=C(F)C(O)=C1F)NC(=O)CCN2CCCC2=O CC1=CC=CC(F)=C1NC(=O)C[C@@H1]2CCN(C(=O)C=3C=C4N=CC=CN4N=3)C2 CSCCCCCC(=O)N[C@@H1]1CC[C@H1](CCC(=O)N[C@H1]2CCN3N=CC=C3C2)C1 CO[C@@]1(CNC(=O)C2=CN=C[NH1]2)CCN(C(=O)CC3COCCOC3)C1 COC[C@@](C)(CO)CNC(=O)[C@H1](CC=1C=N[NH1]C=1)NC(=O)C2=CC(OC)=CS2 COC1=CC=C(C(=O)N[C@@H1](CNC(=O)[C@H1]2COCCN2C)CC(C)C)C(F)=C1Cl CN(CC1(C)COC1)C(=O)[C@H1]2C[C@@H1]2[C@H1]3C[C@H1]4OCC[C@H1]43 C[C@@H1]1C[C@@H1](CNC(=O)CCCC(N)=O)CN(C(=O)C=2C=COC=2)C1 CCCC=C[C@@H1](O)C(=O)N1C[C@@H1](C)[C@H1](CNC(=O)C2=CC=C(F)C(C#N)=C2)C1 COC=1C(C)=CSC=1C(=O)N[C@@H1]2CN(C(=O)C(C)(C)CN(C)C)C[C@H1]2C3CC3 CC[C@H1](C(=O)NCC1=CC=NN1CC)C2(O)CCCCC2 CCC1=CC(C(=O)N[C@H1]2C[C@@H1]3CC[C@H1](C2)N3C(=O)C4=CC=C(Br)C=N4)=N[NH1]1 C[C@H1](CCNC(=O)C1=CC=CC(=O)N1O)N(C)C2=NC3=CC=C(N)C=C3S2 CCC[C@@H1](O)C(=O)N[C@@](C)(CC)CNC(=O)CC1=CC=CC2=CC=CN=C12 C=CC[C@H1](CNC(=O)[C@](C)(OC)C1=CC=CC=C1F)NC(=O)CC CN(CC[C@@H1](NC(=O)C=C(Cl)Cl)C1=CC=CS1)C(=O)C2=CN=C(O)C(F)=C2 CCCNC(=O)C1=CC=C2[NH1]C=C(C3=CN=C(F)C(C)=C3)C2=C1 CCC[C@H1](C)C(=O)N1CCC2(CC1)[C@@H1](N(C)C(=O)C=3SC=CC=3Cl)CS2(=O)=O CCOC(=O)[C@H1](OC)C(=O)N1CCC(CNC(=O)C2=CC(C3CC3)=NS2)CC1 O=C(NC[C@H1]1[C@H1](C2CC2)CCN1C(=O)C3=CN=C(O)N(C4CC4)C3=O)C5=CCC5 C[C@H1]1C[C@@H1](CNC(=O)C(C)(C)CCCl)CN1C(=O)OC(C)(C)C O=C(C[C@H1]1CCCN1S(=O)(=O)C2=CC=CC(Cl)=C2)N[C@H1]3CCCC4=N[NH1]C=C43 CNC(=O)NCC(=O)N[C@@H1]1CCN(C(=O)[C@@H1](NC=O)C(C)C)C[C@@H1]1F CC[C@@H1]1OCC[C@H1]1C(=O)N(C)C[C@@H1](O)CNC(=O)C2=NC=NN2C(C)C CCC[C@H1](CC(C)C)C(=O)N1CC[C@](OC)(C(=O)NCC=2N=COC=2C(C)C)C1 CC1=CC=C(C(C)=CC(=O)N[C@H1](C)CCNC(=O)CSCC(N)=O)C=C1 COC(=O)C[C@]1(N(C)C(=O)C2=CC(C)=C(C#N)C(Cl)=C2)CCNC1 COCCCNC(=O)[C@@H1](C1=CC=C(Br)C=C1F)N2CCS[C@H1](C)CC2 COC[C@@H1]1CN(C(=O)CCCNC(N)=O)CCN1C(=O)[C@H1]2CCC(=O)N2C CC(F)(F)C(C)(C)C(=O)NC[C@@H1]1C[C@H1](CNC(=O)C=CC2=CN=CS2)CO1 CCC[C@H1]1C[C@@H1]1NC(=O)[C@@H1]2CC[C@H1](CNC(=O)C3CCN(C)CC3)O2 C#CCCCCCCC(=O)NC1(C(=O)N2CC[C@]3(CC=CCO3)C2)CCCC1 CC=1C(C(=O)NC[C@@H1]2CCC3(CN(C(=O)C4=CC(O)=CS4)C3)O2)=NOC=1C5CC5 CC1=CC=NC([C@H1](C)NC(=O)CN2CCN(C(=O)C3=CN(C)C=N3)CC2)=N1 CCN(C)CC=CC(=O)NC[C@@H1]1CC[C@H1](CNC(=O)C2=CC=C(C)N(C)C2=O)C1 COC1=CC=CC=2C(CC(=O)NC[C@@]3(O)CCCN(C(=O)C4=COCC4)C3)=COC1=2 COC(=O)[C@@H1](O)CNC(=O)C[C@H1]1COCCN1C(=O)CN2N=CC=C2C COC(=O)C1=NC=C(C(=O)N2CC(NC(=O)C3=CN=NC(Cl)=C3)C2)S1 CC1=CC=C([C@H1](C)NC2=CC=C(S(=O)(=O)NCC(C)(C)C)C(Cl)=C2Br)N=C1 CC(C)(C)[C@H1](C#N)C(=O)NCC(C)(C)C(=O)N1CCSC[C@H1]1CO CC(C)NC(=O)[C@@H1](C1=NC=C(Cl)S1)N(C)[C@@H1]2CCOC(C)(C)C2 C#CC[C@H1](CC(F)F)NC(=O)[C@H1](CC(=C)C)NC(=O)C1=CN=NS1 CC1=CON=C1CC(=O)N(CCF)[C@@H1]2CCCN(C(=O)CN3C=NC(C#N)=N3)C2 CC(=CC(=O)NC[C@H1]1CCN1C(=O)CN2C=C(S(C)(=O)=O)C=N2)C(C)(C)C CN1[NH1]C(=NC(=O)C(=O)[N+1][C@H1]2CCCOC2)C3=C1CCCCCC3 CSCC(=O)N[C@@H1]1CC[C@@H1](N(C)C(=O)C2=CC=NC3=NC=C(C)C=C23)C1 C[C@H1](C(=O)N1CCCC12CCN(C(=O)CCSC3=CC=CC=C3)CC2)C(C)(C)C CCNC(=O)C(=O)N[C@@H1]1C[C@H1](C(=O)N[C@@H1](CO)CC2CCC2)C[C@H1]1O COC1=CC=CC=C1OCCC(=O)N[C@H1]2C[C@@H1](NC(=O)C34CC(C)(C3)C4)C2 CCCC(C)=CC(=O)N[C@@H1](C)C(C)(C)NC(=O)COC1=CC(C)=CC=C1Cl O=C(CSCC1=CSC=N1)N[C@H1]2COC[C@H1]2NC(=O)[C@H1]3CCCC=4N=C[NH1]C=43 C[C@@H1](CN(C)C(=O)C[S@](=O)C1=CC=C(Cl)C=C1)NC(=O)C2=CC(=O)N(C)O2 CCN1N=CC(C(=O)N2CCC(C3(N=C4[NH1]N=C(C#N)S4)CC3)CC2)=N1 C#CC1=CC=C(OCC(=O)N2CC(O)(CNC(=O)CC=C(C)C)C2)C=C1 C=CC[C@]1(NC(=O)C=2C=C(C)[NH1]N=2)CCN(C(=O)C3=CC(F)=CC=C3C)C1 COCC1(C(=O)N2C[C@H1]3CCN(C(=O)C4CCOCC4)C[C@H1]3C2)CCC1 C[C@H1]1CN(C(=O)C=CSC2=CC=CC=C2)CC[C@H1]1NC(=O)C3=CC(N)=CN=C3Cl CCCC1(C(=O)NC[C@@H1](C(=O)NC[C@@](C)(OC)C2CC2)N(C)C)CC1 CCN1C=CC(CN(C)C(=O)[C@H1](C)N(C)C(=O)C=2C=COC=2Cl)=N1 CC1=C(C(=O)N[C@@H1](C)CN(C)C(=O)[C@@]2(F)C[C@@H1]2C)C=CC=C1[N+1](=O)[O-1] C[C@@H1]1CCN2N=CC(C(=O)NC3=CC=C(C(=O)NCC(=O)O)C(Cl)=C3)=C2C1 CCN(C(=O)C1=CSC(C(C)(F)F)=N1)[C@H1]2CCN(C(=O)[C@@H1]3CC(=O)N(OC)C3)C2 CCCC1(CNC(=O)[C@H1]2CC[C@H1](O)CN2C(=O)CCC(C)(C)N(C)C)CCC1 O=S1(=O)CC[C@@H1]1CNC2=NC=C(S(=O)(=O)N3CC=CC34CCCC4)C=C2Cl O=C(N[C@@H1]1CCC[C@@H1]2CN(C(=O)C3=CN=C(C4CC4)O3)C[C@H1]21)[C@H1]5C=CCCC5 C[C@@H1]1CC[C@@H1](NC(=O)[C@@H1]2CN(C(N)=O)CCO2)CN1C(=O)C=3C=CON=3 C=CC[C@H1](CC)C(=O)N1CCC[C@@](F)(C(=O)N2CC3(CO)CCC2CC3)C1 CC(C)(CCCNC(=O)[C@@H1]1CC(=O)OC1(C)C)NC(=O)CS(C)(=O)=O CC(C)C=1SC=NC=1C(=O)NCCC2=CCN(C(=O)C3[C@H1](C)[C@H1]3C)CC2 CC[C@@H1](CN(CC)C(=O)[C@@H1]1CC[C@H1]2[C@@H1](C1)C2(F)F)NC(=O)CC3=C(Cl)C=NN3C O=C(NC1=CC=C(N2N=NC3=CC=CC=C32)C=C1)C=4C=CC5=CC=NN5C=4 CCCC=CC(=O)N1[C@H1]2CCC[C@H1]1CN(C(=O)C3=CC(C#N)=CS3)CC2 CCCN(CCCNC(=O)[C@H1](C)COC)C(=O)CCCCNC(C)=O O=C(CC1=CC=CC(F)=C1)N[C@@H1](CNC(=O)[C@@H1](O)C=2C=CSC=2)C3=CC=CC=C3 CC1=CC=C(C(=O)N2CCSC[C@@H1]2C(=O)NC[C@H1](O)C3=CC=CC(O)=C3)C=C1Cl O=C(CC=1N=C[NH1]N=1)NC[C@@H1](CC(F)(F)F)NC(=O)C2(C3=CC=C(F)C=N3)CC2 O=C(NCC1(F)CN(C(=O)C=C(Cl)Cl)C1)C23C[C@H1]4C[C@@H1](CC(O)(C4)C2)C3 COCC1(CC(=O)N2C[C@H1]3[C@@H1](C2)OC(C)(C)CN3C(=O)[C@H1](C)C(C)(C)C)CC1 COC(=O)N1C[C@H1]2CC[C@H1]1[C@H1](C(=O)NC[C@H1](O)C3CCCC3)C2 C[C@H1](CN1C=CC=N1)C(=O)N2CCN(C(=O)[C@@H1]3CCC(=O)NC3)C[C@H1](O)C2 C=C(C)C[C@H1](C)C(=O)N1CC2(CCN(C(=O)CCO[C@H1]3CCOC3)CC2)C1 C[C@@]1(C2=CN(CCOCCO)N=N2)CCCN1C(=O)C3=NN=C(O)C=C3O CC1=NN(C)C=C1CCC(=O)NC[C@@H1]2C[C@H1]2CNC(=O)COCC3(F)CC3 CC1=CN=C(CC(=O)NCCC[C@@H1]2CCCCN2C(=O)[C@@H1](F)CC(C)C)[NH1]1 CC1=CC(C(=O)NC2=CC=CC(C3=CC=C(C)S3)=C2)=NC=C1CO CN1N=NC2=C1NCC[C@@H1]2C(=O)NCCC(=O)C3=CC=CS3 COC(=O)C=1C=CN([C@H1]2C[C@H1](NC(=O)NC[C@H1](OC)C3=CC=CC=C3OC)C2)N=1 CCN(CC)C(=O)[C@H1](C)NC(=O)[C@@]12C[C@@H1]1CCN2C(=O)CCC3(C)CC3 CC(=O)[C@@H1]1C[C@H1](CC(=O)N2CC[C@](C)(NC(=O)CCN3CC[C@@H1](F)C3)C2)C1(C)C CCC[C@H1](CCCNC(=O)CCCCCF)NC(=O)[C@H1]1CCC=2N=C(C)SC=2C1 CCCN(CCNC(=O)C=1OC=CC=1COC)C(=O)CC2=CC=C(Cl)C(F)=C2 CO[C@@H1](CC1CCCC1)C(=O)N(C)CCOCCN(C)C(=O)[C@]2(C)CC(C)=NO2 CC(C)[C@H1](C)C(=O)N[C@H1]1CC[C@](F)(CNC(=O)C2=CC=C3C=CC=C(F)C3=N2)C1 CCC1=CC(NC(=O)[C@H1](C)[C@@H1](C)NC(=O)CC2(C)CCC2)=CC=C1C CC=CCC(=O)N1CC[C@@H1](NC(=O)[C@]2(C)CCCS2(=O)=O)[C@H1](O)C1 CN1N=NC(CN2N=NN=C2[C@@H1](CCCCC3CC3)NCCCOCC(F)F)=N1 CC1=C(C(=O)NCC[C@]2(C)CCN(C(=O)C3=C(N)SC(C)=C3C)C2)CCO1 CC(C)(F)[C@@](C)(F)CNC(=O)[C@H1]1CN(C(=O)C2=CC=CN2C3CC3)CCO1 CN1CCCC[C@H1]1CCC2=CN(CCCNC(=O)CCS(=O)(=O)N(C)C)N=N2 [N-1]=[N+1]=NC1=CC=NC=C1C(=O)NCCNC(=O)C2=CC=NN=C2O CCN1CC[C@@H1](C(=O)N[C@@H1]2C[C@@]3(NC(=O)C=CC4CC4)CO[C@@H1]2C3C)C1 COCCC(=O)N1CCCC[C@H1](CNC(=O)C2=C(C)OC(C3=CC=C(Cl)C=C3)=N2)C1 O=C(NC[C@@H1]1C[C@@H1]2COC[C@H1]2N1C(=O)[C@H1](O)C3CC3)C4=CN=CC5=CC=CN=C45 C[C@@H1](CCNC(=O)[C@@H1](C)C1=CC=CO1)CCNC(=O)[C@@H1](O)CC=2C=NN(C)C=2 CC1=CC(C(=O)N2C[C@@H1](O)C[C@@H1](NC(=O)C3CCC4(CC3)CC4)C2)=NC(C)=N1 O=C(CC=1C=NSC=1)NCC=C2CCN(C(=O)CN3CCCC3)CC2 CN(C(=O)C1=CC=NC=C1Cl)[C@H1]2CCN(C(=O)[C@@H1]3CC4CC3C4)C2 CCN1CCOC[C@H1]1C(=O)NCC2=CC=C(CNC(=O)CN(C)C3CC3)C(F)=C2 CC[C@@H1](O)CN(C)C(=O)CCC[C@@H1](C)NC(=O)C1=CC=CC(C)=N1 C[C@@H1](C(=O)NCC1=CSC(C(=O)N(C)CCN2CCOCC2)=C1)[C@H1]3CCCO3 C=C1CC[C@@]1(C(=O)N2CC[C@](CF)(NC(=O)C3=CN=C(N(C)C)N=C3)C2)C(C)C C=CC[C@H1](C)C(=O)N(C)[C@H1]1CCCN(C(=O)C=2ON=C3C=CC=CC=23)C1 C[C@@H1]1CN(C(=O)C2=N[NH1]C3=C2CN(C(=O)COC4(C)CCC4)C3)CC[S@]1=O COC(=O)C1=C[NH1]C(C(=O)NC[C@]2(C)CCN(C(=O)[C@H1](F)C3CC3)C2)=C1 C[C@@H1](O)[C@@H1](CO)NC(=O)[C@]12C[C@H1]1CN(C(=O)C3=CC=CC(I)=C3F)C2 CC(C)CO[C@H1](C)C(=O)NC[C@](C)(CO)NC(=O)C=CCF CON1CCC(C(=O)N2C[C@H1](NC(=O)C3SCCS3)CC[C@@H1]2C)CC1 CN1C=CC=C1C(=O)C(=O)N2CCC(NC(=O)C3=CC=C4N=N[NH1]C4=C3)CC2 CSC1=CC=CC=C1C[C@H1](C)NC(=O)C=2C=C(C3=CC=CC=C3Cl)ON=2 CCCN1N=NN=C1[C@H1](N[C@@H1](C)C(=O)NCCCOC)C=2N=C(CC)SC=2Br N=C1[NH1]C=C(C(=O)N2C[C@H1]3CCN(C(=O)CN4C=NN=C4O)[C@H1]3C2)O1 O=C(NCC12CCC(CC1)CN2C(=O)C3=CC=NC=N3)C4=NSN=C4O C[C@@H1]1CN(CCCC(=O)NCC2=CC=C(S(N)(=O)=O)C=C2)CCC(F)(F)C1 CC(C)[C@H1](F)C(=O)NC[C@@H1]1CC2(CO1)CN(C(=O)CN3CCC(C)(C)C3)C2 O=C(N[C@H1]1C[C@@H1](O)CN(C(=O)C2=CC=NC(C3CC3)=C2)C1)C4=CC=C([N+1](=O)[O-1])[NH1]4 CCN1C=C(Cl)C(C(=O)NC[C@H1]2C[C@@H1]2NC(=O)C3=C(F)C=CC(OC)=C3F)=N1 CCCOC1=CC=C(C(=O)N[C@@H1](C)C2=NN=C3C(=O)[NH1]C=CN23)C=C1OCCC CCC1(C(=O)N2CC[C@@H1](NC(=O)COC(F)(F)F)[C@@H1](CO)C2)CC(C)(C)C1 CSC[C@@H1](C)C(=O)N(C)C[C@@H1](C)NC(=O)/C=C/C1=CN=C2C=CC=CC2=C1 CC1=NO[C@@H1](CC(=O)NC[C@@H1]2CCN(C(=O)C=3C=CC(=O)OC=3)C2(C)C)C1 COC(=O)N1CCC[C@@H1](NC(=O)C2=CC=CC=C2N3C=C(C4CCC4)N=N3)C1 CC1=CC(C(=O)N2CC(NC(=O)C[C@H1](C)O)(C(N)=O)C2)=NN1C CCC1=NN=C(CN2CCC[C@@H1]2CNC(=O)C3=CC=C(F)C=4OC=CC3=4)S1 C=CC[C@](C)(CO)CNC(=O)[C@@]1(CO)CCN(C(=O)[C@H1](O)CC(C)(C)C)C1 O=C(NCC[C@H1]1C[C@@H1](NC(=O)[C@H1]2C[C@@H1]3CC[C@@H1]3C2)C1)[C@H1]4CCC5(CCOCC5)C4 C=CCO[C@@H1](C)C(=O)N1CCCN(C(=O)CC2(C=C)CCC2)[C@H1](C)C1 CC[C@@H1](CC(=O)N1C[C@H1]2C[C@@]2(CNC(=O)C3CCOCC3)C1)OC CC(=CC1=CC=C(F)C=C1)C(=O)N2CC[C@H1](C)[C@H1]2CNC(=O)C=3C(C)=NOC=3C CC(C)CN(CC=1C=NN(C)C=1)C(=O)[C@@H1]2CC3=CC(Cl)=CC=C3C(=O)O2 O=C(CN1C=C(Br)C=N1)N2CC[C@@]3(CCN(C(=O)C4=CC=C(I)C=C4O)C3)C2 O[C@@H1](COC1=CC=CC(Cl)=C1)CN[C@H1](CCl)C2CCOCC2 CCO[C@H1](C)C(=O)N1C[C@H1](OC)C[C@H1]1CNC(=O)CN2CCC(C)(C)C2 CC1=CC(Cl)=NC(I)=C1NC(=O)C2=CC=C(N3CCC(C)(C)C3)C=C2 CC1=CC(C(=O)N[C@H1]2C[C@H1]2NC(=O)C3=CC(C(N)=O)=NO3)=NN=C1C O=C(NC1(C2=NC=NN2C)CC1)C3=CC4=C(S3)CCCNC4 O=C(NCCC1=CC=CC=C1)[C@@H1]2C[C@H1](O)CN2CC3=CC=CC(O)=N3 C[C@@H1]1C[C@H1](NC(=O)N2CCOCC[C@@H1]2C(F)F)CCS1 CCCN1CC(N=C2[NH1]C(N3CC[C@H1](C4CCCCC4)C3)=NC5=CC=CC(F)=C25)C1 COC1=CC=C(F)C(C(=O)N(C)CCNC(=O)[C@]23CCO[C@H1]2CC(=O)NC3)=C1 CCCN(C)CCC(=O)N[C@@]12CCCC[C@@H1]1CN(C(=O)C=3C(CO)=NOC=3C)C2 CN(C(=O)C(F)(F)C1=CC(Cl)=CC=C1Cl)[C@@H1]2CCN(C(=O)[C@@H1]3C[C@H1]3C4CCC4)C2 C=C=C(C)CC(=O)NC1(CC(N)=O)CCN(C(=O)C2=CC=C(C)C=C2OC)CC1 CO[C@H1](C)CC(=O)NC[C@@H1]1CC[C@H1]2CN(C3=CC(C(C)C)=NC=N3)CC[C@H1]2C1 C[C@@H1](/C=C/C(=O)N[C@H1](C)CC(C)(C)CO)NC(=O)[C@@H1]1C[C@H1]2C[C@@H1]1C[C@H1]2O CC1(C)[C@H1]2CC[C@]1(C(=O)N[C@@H1]3CN(C(=O)CSC4=NN=CN4C)C[C@H1]3O)C2 CN(C(=O)C[C@@H1]1CCCN1C(=O)C2=CC(Cl)=NO2)C(CF)CF CC(C)COCCC(=O)NC[C@H1]1CN(C(=O)CC=2C=CN(C)C=2)C3(CCC3)C1 C[C@H1](C(=O)N1C[C@H1](C(=O)N[C@H1]2CC[C@H1]3CCC[C@@H1]2O3)CC1(C)C)C4CC4 COC[C@]1(C(=O)O)CCCN(C(=O)CC2(N(C)C)CCCC2)C1 CC1=CC(C(=O)N(CCC(=O)NC2=CN=CC(C#N)=C2)CC3CC3)=CC(C)=N1 CN(CCN(C)C1CC1)C(=O)CNC(=O)CNC(=O)CC(F)(F)C(F)F C[C@H1]1C[C@@H1]1CCCNC(=O)/C=C/[C@@H1]2CCCN2C(=O)/C=C/C(C)(C)C CC1=NN(C)C=C1CCC(=O)N[C@H1](C)CN2C=C(COC(=O)C(F)(F)F)N=N2 CN1CCC(F)(C(=O)N[C@H1]2COC[C@H1]2N3C=C(C4=CC=NC=C4)N=N3)CC1 CS[C@@H1]1COC[C@H1]1NC(=O)[C@@H1]2CC3(CC3)CN2C(=O)CC4=CCCCC4 O=C(N[C@@H1]1CCN(C(=O)C2=COCCC2)CC[C@@H1]1CO)[C@H1]3CCC4(CCC4)C3 [N-1]=[N+1]=NC1=CC=CN=C1N[C@@H1]2COC[C@@H1]2N3C=C(CCCC)N=N3 CCCC(C)=CC(=O)N(C)CCCCCNC(=O)[C@H1]1CCC(=O)N1 CC=CC(=O)N1CCC[C@@H1](C(=O)N2CCN(C(=O)C3=CC=CS3)CC2)C1 CC1=N[NH1]C(C)=C1C(=O)N2CC[C@@H1](C(=O)N3CC(C)(C(N)=O)C3)C2 CC1=CN=C(N2C[C@@H1]3CCCN3C[C@@H1]2C)C(C#N)=C1 C#CC[C@@H1](C)NC(=O)C1=CC=C(CNC(=O)C2=CN=CN=C2)S1 C[C@@H1](CO)C(=O)NC[C@@H1]1CCN(C(=O)COC2=CN=CC(Br)=C2)C13CC3 COC1=C(C)C=CC(C(=O)N2C[C@@H1]3CN(C(=O)[C@H1]4CC4(C)C)CC[C@@H1]32)=C1F CSCC[C@@H1](O)C(=O)N[C@H1]1CC[C@](F)(CNC(=O)CCC(=O)NC2=NC=CS2)C1 O=C(N=C1N=C[NH1]N2C(Br)=CC=C12)C3=CC(NC(=O)C(Cl)(Cl)Cl)=CN3C N#CC(C#N)CCN(CCC[C@H1]1C[C@@H1]1)C COC(=O)C1=CC(C)=CN=C1NCC2(CNC(=O)CN3N=NC(C)=N3)CCCC2 CC1(NC(=O)CCC(=O)C2=CC=CC=C2)CN(C(=O)[C@H1](O)CC3=CC=CC=C3)C1 C[C@H1]1CN(C(=O)C=2SC(C#N)=CC=2Cl)[C@H1](C)CN1C(=O)C3=CC=C4OC=NC4=N3 CN(CC1CN(C2=CC=NC(S(C)(=O)=O)=N2)C1)C(=O)CCCS(N)(=O)=O CC1(C(=O)N2CC[C@@](C)(CNC(=O)C[C@H1]3OCCOC3(C)C)C2)CC4(CCC4)C1 C=C(C)C[C@H1](C)C(=O)N(C)CCC1CCN(C(=O)C[C@H1](C)C=2C=NN(C)C=2)CC1 CCC(=O)N1CCC[C@H1](C(=O)NCC2CN(C(=O)CCCCCS(N)(=O)=O)C2)C1 C[C@@H1](CCC(=O)NCCNC(=O)N(C)C)NC(=O)CCN1C=NC(=N)[NH1]1 CC[C@@H1]1CN(C(=O)C2=CC=NC(Cl)=C2C)CC[C@H1]1NC(=O)C=3N=NN(C)C=3N C[C@H1](CNC(=O)C1=CC(F)=CC(F)=C1)NC(=O)C=2C=CN(C3CCCC3)N=2 C[C@H1]1OC2(C)CC1(C(=O)N[C@H1]3CCN(C4=NC=C5C(=N4)COC5)[C@@H1]3C)C2 CC(C)CC[C@H1](O)C(=O)NC[C@@]12CCC[C@@H1]1N(C(=O)C3=CC=NC(S)=C3)CCC2 C#CCC(CC#C)C(=O)N1CCC2(CC1)C[C@H1]2CNC(=O)CC#N C[C@@H1](CNC(=O)C[C@H1]1COCC(C)(C)O1)CN(C)C(=O)C2=CC(C(N)=O)=CO2 COC1=NC=C(Cl)C(N(C)C2CCN(C(=O)[C@@H1]3CCO[C@H1](C(C)C)C3)CC2)=N1 CCOC[C@H1](C)C(=O)NC[C@H1]1CC[C@@H1](NC(=O)C2=CN(C3CCC3)N=C2C)C1 C=CCCO[C@@H1](C)C(=O)N[C@@H1]1C[C@H1](C(=O)N2CC[C@H1](N3CCCC3)C2)C[C@H1]1O CC1=CC=C(CC(=O)NC2CCC(N(C)C(=O)[C@@H1]3CCCSC3)CC2)S1 CC=1N=C(C(=O)N2CCC(C)(CNC(=O)COC3CCC3)CC2)C(=O)[NH1]C=1C N#CC1=CC=C2C(CN3CC(O)(CNC(=O)C4=CC=CC(I)=C4Cl)C3)=C[NH1]C2=C1 CCCN(CC(=O)NCC[C@H1]1C[C@H1]2CC[C@H1]1C2)C(=O)[C@H1]3C[C@@H1](O)C3 O=C(C1=COC(Cl)=N1)N2C[C@@]34CCC[C@]3(C2)CN(C=5[NH1]C=NC6=NC(Cl)=CC=56)C4 CCC1=CN=C(CC(=O)N[C@H1](C)[C@H1]2CCN(C3=NN=CS3)C2)[NH1]1 CCO[C@@H1](C)C1=NC(C(=O)N(C)C[C@H1](C)N(C)C(=O)CC2=CSC(S)=N2)=CS1 C=C[C@@H1](C)C(=O)N1[C@@H1]2COC[C@H1]1C[C@@H1](NC(=O)C[C@@H1]3CCCO3)C2 CCC=1C=NOC=1C(=O)NCC2=NC(O)=CC(CNC(=O)[C@H1]3C[C@@H1](O)C3)=N2 CS[C@@H1](C(=O)N[C@@](C)(CNC(=O)C1=CC(F)=C(F)C(O)=C1F)C(C)C)C(C)C CCCC(C)(C)C(=O)N1CCC2(CC1)C[C@@H1]2NC(=O)[C@@H1]3CN(C(C)=O)CCO3 O=S(=O)(CCOC1CCSCC1)NCCN2CCC3(CC2)CNC3 O=C(NC[C@H1]1CCN(C(=O)[C@H1]2CCS(=O)(=O)C2)C1)C3=CC=C(N4C=CN=C4)C=C3 O=C(CCN1C=CC=C1)N2CC=C(CNC(=O)[C@@]34CCC[C@@H1]3C4(F)F)CC2 COC1=CC=NC(C(=O)N2CC[C@H1]3CCC[C@@]32C(=O)NCC(=O)N(C)C)=C1 C#CC(C)(C)CNC(=O)[C@H1]1CCC2=CN(C)N=C2C1 COC(=O)C=1C=C(CCCNCC2=CN=C(C3=CC(Cl)=CC(Cl)=C3)S2)OC=1C C[C@@H1](NS(=O)(=O)CC1=CC=CC=C1)C(=O)NC[C@@H1](C)CNC(=O)[C@H1]2CCO2 CC=1C=C(C)[NH1]C(=NCCCC[C@H1](C)NC(=O)C2=CN=C3C=CC=CC3=N2)N=1 CSCC1(C(=O)N[C@@H1]2COC[C@@H1]2CNC(=O)[C@H1]3CCCC[C@@H1]3O)CCC1 CC1=CC=C(F)C(C(=O)NCC=2C=C[NH1]C=2C(=O)NC3=CC=CC=C3)=N1 CC[C@@H1](C)C[C@@H1](C)C(=O)N[C@H1]1C[C@](C)(NC(=O)C2=NC(C)=NN2C)C1 C=CC[C@]1(NC(=O)[C@@H1]2CCS(=O)(=O)N2C)CCN(C(=O)C3=CC=CC(F)=C3Cl)C1 CCCCN(C)CCNC(=O)N1CCOC2=NC=CC(Cl)=C2C1 CNC(=O)CCC(=O)N1CCC(CCNC(=O)[C@@H1]2C[C@@]23CCOC3)CC1 CC1=CSC=C1C(=O)N2C[C@H1](C)[C@@H1](NC(=O)C3=C(F)C(C)=NN3C)[C@H1](C)C2 CCCCCCCCCC(=O)N(C)CCNC(=O)[C@@H1]1CCC2(CC2)C1 CC1=CC=C(Br)C(CN2CC[C@H1](C(=O)NC3=NC(Br)=CC=C3C#N)C24CC4)=C1F C[C@H1]1CN(C(=O)[C@H1]2CC=CCC2)[C@H1]1C(=O)N3CC[C@@]4(CNC(=O)N4)C3 C[C@@H1]1CN(C(=O)C2=CC=3SC=C(Cl)C=3[NH1]2)CC[C@@H1]1CNC(=O)C4CCC4 C=C[C@@H1]1CCN1C(=O)C2=CC=CC(CNC(=O)CC3COCCOC3)=N2 CC(C)C1CC(C(=O)N(C)CCCNC(=O)[C@@H1](C)C2=CC=C(Br)C=C2)C1 CC(C)(O)[C@@H1](F)C(=O)N1C[C@H1]2C(CNC(=O)C3=CC([N+1](=O)[O-1])=C(Cl)C=C3Cl)[C@@H1]2C1 COC(=O)N[C@H1](C(=O)N1C[C@H1]2C[C@H1](NC(=O)COCC(F)F)C[C@H1]2C1)C(C)C N#CC1CCN(C(=O)CN2C=NN=C2)CC1 O=C(NC1COC1)[C@H1](C2=CC=C3C(=C2)CCCS3)N4CCC[C@@H1](C5CCCC5)C4 CC1=CSC(CC(=O)N(C)CCN(C)C(=O)CN2CCN(S(C)(=O)=O)CC2)=C1 CCC12CN(C(=O)CCC3CCCCCC3)C(CNC(=O)C4=CCCC4)(C1)C2 CN1N=NN=C1SCC(=O)N2CC[C@H1](CNC(=O)C=CC=3C=N[NH1]C=3)C24CC4 CCN(CC)CC(=O)N[C@@H1]1C[C@H1]1NC(=O)[C@@H1]2CCCN(C(C)(C)C)C2=O CC1=NC=C(C(=O)N[C@H1]2CN(C(=O)C3=CC(Cl)=CN=C3O)CC[C@@H1]2C)[NH1]1 CC1=CC=CC(CN2CCC[C@@H1]2C(=O)NCCNC(=O)C3=CC=NC=N3)=C1O CC[C@@H1](C(=O)OC)C(=O)N1CCC(CNC(=O)C=2C(C)=NOC=2C(F)F)CC1 O=C(CC1=CC2=CC=CC=C2O1)NC[C@@H1]3CCCC[C@@H1]3NC(=O)CC4(O)CC4 C[C@H1]1CN(C(=O)[C@@H1]2CCC3(CC3)N2C(=O)C=4C=CN5N=CC=C5C=4)C[C@@H1]1CO CC1=CCS[C@@H1]1C(=O)N[C@@H1]2CCC[C@@H1]2CNC(=O)C=3C=C4N(C=3)CCCC4 CSC[C@@](C)(NC(=O)CCC(C)(C)[N+1](=O)[O-1])C(=O)NCC[C@H1]1C[C@H1]2C=C[C@@H1]1C2 COC[C@@]1(C)C=CCN1C(=O)CC2CCN(C(=O)CC3=CC=C(C)N=C3)CC2 C[C@]1(CNC(=O)C2=CC=CC3=C2CCC3)CCCN1C(=O)C4=CC=C(Cl)C(N)=C4 O=C(CC=1C=CC2=NSN=C2C=1)N[C@@H1]3COCCN(C(=O)CN4C[C@H1]5C[C@H1]5C4)C3 CS(=O)(=O)C1CC(C(=O)N2C[C@@H1](NC(=O)[C@H1]3CNC(=O)C3)[C@H1](CC4CC4)C2)C1 C=C(C)[C@H1](CC(=O)NC1(CC)CN(C(=O)C2=COC(C(=O)OC)=N2)C1)OCC CC1=CC(C(F)(F)F)=CC=C1CNC(=O)N2CCCC2(C)C CN1N=C(C(=O)N2CC[C@@H1]2CNC(=O)C=3N=CN4C=CC=NC=34)C5=C1CCCC5 CCC(CC)(CC)C(=O)NC[C@@H1]1CC2(CC2)CN1C(=O)CO[C@H1]3CCOC3 CCCN(C(=O)C1=CSC=C1Cl)C2CCN(C(=O)C(=O)NC3CCCCC3)CC2 C[C@H1](C(=O)N1CCCC(NC(=O)[C@H1]2COC(=O)N2)CCC1)C3=CC=C(F)C=C3F CC=CC=CC(=O)N(CC)C1CCN(C(=O)C23CCC(CC2)CC3)C1 C[C@@H1](N=C1[NH1]C(=N[C@@H1]2CCC3=C(F)C=CC=C32)[NH1]C4=C1SCC4)C5=CC=C[NH1]5 CN1CCC[C@]1(C)C(=O)N(CCCNC(=O)[C@@H1]2COCCN2C=O)C3CC3 C#CC1=CN(C)N=C1C(=O)N2C[C@@H1](C(=O)N[C@H1](CCC)C=3N=N[NH1]N=3)CC2(C)C CC=CC=CC(=O)NCC[C@H1](O)C(=O)N(C)C[C@@H1](OC)C(C)C C=CC(F)(F)C(=O)NC[C@@H1]1CN(C(=O)CNS(=O)(=O)CCCC)C(C)(C)C1 CC1=CC(=N[C@@H1]2CCCN3CCC[C@H1]23)[NH1]C(=NCC4(C)CCC(C)(C)CC4)[NH1]1 C[C@H1]1CN(C(=O)[C@@H1](C)C2CCCC2)CC[C@H1]1C(=O)N3CCC4=CC=NC=C4C3 CCCN(C)CC(=O)N[C@@H1](C)[C@H1](C)NC(=O)C1=N[NH1]C2=C1CCCCC2 N=C1[NH1]C(CCC(=O)NC[C@@H1]2CC[C@H1](NC(=O)[C@H1]3COCCO3)C2)=CS1 CC(C)C[C@@H1](C(=O)N1CCC[C@@H1](N=C2C=CN=C(C(C)C)[NH1]2)C1)N3C=CN=C3 CCC1=NC(C#N)=CC(=NC[C@H1]2CN(C(=O)CCC3CCCC3)CC[C@@H1]2C)[NH1]1 O=C(NCC1=CN=C(O)C2=CC=CC=C12)C(F)(F)CCN3CCOCC3 CCOC[C@H1](C)C(=O)NC[C@@H1](C)NC(=O)CC1=CC=C(S(=O)(=O)N2CCCC2)S1 O=C(CC1=CC=CN=C1)NC[C@@H1]2CCN(C(=O)CN3C=NN=C3O)C[C@@H1]2O O=C(N[C@@H1]1CCC[C@H1]1NC(=O)[C@@H1](F)C2=CC=CC=C2)C3=CC=C(Cl)C=C3[N+1](=O)[O-1] CC1(C(=O)N[C@@H1]2C[C@H1]2C3CCN(C(=O)[C@@H1]4CC5CC4C5)CC3)CCOCC1 O=C(CC[C@H1]1CCOC1)NC2CC3(CCN(C(=O)C4=CN=C5N4CCS5)C3)C2 CSCC[C@@H1](O)CC(=O)N1CCN(C(=O)[C@@]2(F)CCCN(C)C2)C3(CCC3)C1 CC1=CC(Cl)=CC(C(=O)NC[C@H1]2C[C@H1](CNC(=O)CN3C=CC(=O)C=C3C)C2)=C1 CC1=CC2=CC=CC([C@H1](C(=O)NCC(F)F)N(C)CC3=CN=C(C)S3)=C2O1 CC1=CN2C=CN=C(C(=O)N[C@@H1]3CCCN(C(=O)C4=NN=CN4C5CC5)C3)C2=N1 CCC(CC)CCC(=O)N1CC(CNC(=O)C[C@H1]2CCC(=O)NC2)(C(C)(C)O)C1 C[C@@H1]1CCN(C(=O)C2CS(=O)(=O)C2)[C@@H1]1C3=CN(CC4=CC=CC(C(=O)O)=C4)N=N3 CC(C)N1C=CN=C1C(=O)N[C@@H1]2C[C@H1]3CC[C@@H1]2N3C(=O)[C@H1]4CN5CCC4CC5 O=C(NCC1(C(=O)NC2CCC3(CCC3)CC2)CC1)C4=CCCCC4 CC=1[NH1]N=C2C=C(C(=O)NC3=CC=CC([C@@H1](F)C(F)(F)F)=C3)C=CC=12 O=C(NCC1=CN=C(Cl)C(Cl)=C1)C2CCN(CC3=CC=C([N+1](=O)[O-1])S3)CC2 CN=C1[NH1]C=C(C(=O)N[C@@H1]2CCCN(C(=O)C=3SN=C4C=CC=CC=34)CC2)S1 C=C1CC(CNC(=O)[C@H1]2CCCS[C@H1]2C)(C(=O)N3CCC=4N=C(C)[NH1]C=4C3)C1 CC1(NC(=O)[C@H1]2C[C@@H1]3COCCN3C2)CN(C(=O)C=4C=C(C5=CC=CO5)ON=4)C1 C[C@@]1(C(=O)NC2CC(CCNC(=O)C(F)(F)C3=CCOCC3)C2)CCCCO1 O=C(C1=CC(C(F)F)=NO1)N2CC[C@@H1]3CCN(C(=O)C4=CN=N[NH1]4)C[C@H1]3C2 CC(C)[C@@H1](CCNC(=O)C1C2CCC1CC2)NC(=O)[C@@H1]3CC4=CC=CC=C4N3 CCOC[C@H1](NC(=O)CC1(N(C)C)CC1)C(=O)N(C)[C@H1](CO)C2CC2 CCC[C@H1](NC(=O)C=1N=COC=1CNC(=O)[C@H1]2CCC[C@H1](OC)C2)C3=CC=CO3 CN(CCC1=CC=CN=C1)C(=O)[C@@]23C[C@H1]2CCN3C(=O)CC4=CC=NN4C COC1(CC(=O)N[C@]2(C)C[C@@H1](NC(=O)C=3N=C[NH1]C4=NC=NC=34)C2)CCCCC1 CC(C)C[C@H1](ONC(=O)[C@@H1]1[C@H1](C#N)C1(C)C)C(=O)NCCC[C@H1]2CCOC2=O C[C@H1](C[C@@H1](C)C(F)F)NC(=O)[C@@H1](CNC(=O)C1=CC=NS1)CC2CCCC2 CC(C)(C)[C@@H1]1CCC[C@@H1](NC(=O)NNC(=O)C=2C=C3C=CC=CN3C=2)C1 F[C@@H1]1CCN(C(=NCCCN=C2C=C[NH1]C=C2)NC3CC3)C1 CCC=1N=NSC=1C(=O)N[C@@H1]2CN(C(=O)C3=CC(C)=C(C)C(F)=C3)C[C@H1]2C COC1=NC=C(C(=O)NC[C@@H1]2CC[C@@H1]3CN(C(=O)CC=C(Cl)Cl)C[C@@H1]32)C=N1 CC[C@]1(C(=O)N(C)C[C@H1]2CCC[C@H1]2O)CCN(C(=O)C3=CC=C(C)C=C3O)C1 CC(C)(C)[C@@H1](CO)C(=O)N1C[C@H1](CC(=O)N2CCC(CCF)CC2)C3(CC3)C1 O=C(C[C@@H1]1CCCNC1=O)NCC2=CC(C(=O)NCCNC(=O)C3CCC3)=N[NH1]2 CCN(C(=O)[C@H1]1C[C@@H1](O)C1)[C@H1](C)CNC(=O)CC2=CSN=C2 CCCCCC1CC(NC[C@@](C)(O)C=2C=CSC=2)(C3=NN=NN3C4CCCC4C)C1 C#CC[C@H1](C)NC(=O)CN(CCC)C(=O)CC[C@@H1]1C[C@H1]1C CC(C)(C)C(=O)N1CSC[C@H1]1C(=O)NCCCNC(=O)[C@@H1](F)C2CCOCC2 CN(CCCC(=O)NCCC1(O)CN(C(=O)[C@@H1]2CCCOCC2)C1)N=O COC(=O)COCC(=O)N1CC2(C1)CN(C(=O)COCCC3=CC=CC=C3)C2 CC1(C(F)(F)F)CCN(C(=O)C=CC2=CC=C(C3OCCO3)C2)CC1 CO[C@H1](C(=O)N1CC[C@H1]([C@H1]2CCCCN2C(=O)C3=CC=[N+1]([O-1])C=C3)C1)C4CC4 CN(C(=O)C1([C@@H1]2CCCO2)CC1)[C@@H1]3CN(C(=O)C4=NN=C(O)N=C4O)C[C@H1]3O CC1=CC=CC(OCC(=O)N2CC=C(CNC(=O)C3CN(C(C)C)C3)CC2)=C1C CCC(CC)CN1CCC(CNC2=CC(=NCC3(F)CC3)[NH1]C(C)=N2)CC1 CC=1N=C[NH1]C=1C(=O)N2CC[C@@H1](N(C)C(=O)C3=CC=C4N=CC=NC4=C3)[C@H1](C)C2 C[C@H1]1C[C@@H1](C2=NC(C3=CN=CC4=CC=CC=C34)=NO2)C15CCC5 CC(C)[C@@H1](CNC(=O)C1=CN=NN1C)NC(=O)C2=CC=C(C3=CC=NC=C3)N=C2 CNC(=O)C1=CC=CC(C(=O)NC2(CNC(=O)C3=CN=C(SC)S3)CCC2)=C1 O=C(NC1=NC2=C(S1)COC3=CC=CC=C32)[C@H1]4CCN(C5=CC=C(Br)C=N5)C4 CCN1C=CC(C(=O)N[C@@H1]2C[C@H1]3[C@@H1](C2)[C@@H1]3NC(=O)C=4SC=CC=4C)=N1 CCS[C@@H1](C(=O)N(C)C[C@H1]1CCCCN1C(=O)C=CC2=CC=NN2CC)C(C)C CC=1N=C(C(C)C)OC=1C(=O)N[C@H1](C)[C@@H1](C)NC(=O)C2=NN(C)C=C2Br CCOC1=CC=CC(C(=O)N2CC(CCNC(=O)[C@H1]3CCCC[C@H1]3CC)CC2)=C1 CC1(C)C[C@H1](CO)N(C(=O)[C@@H1]2CCO[C@H1]2CNC(=O)CC(Cl)Cl)C1 CC[C@H1](CN(C)C)C(=O)N1[C@H1]2CC[C@@H1]1C[C@@H1](NC(=O)CCCOC(C)C)C2 CN1C=CN=C1C[C@H1]2CCCN(C(=NCCCC(F)(F)F)N[C@@H1]3CCOC3)C2 CC(C)(C)[C@H1](CNC(=O)C1=CC(O)=NO1)N=C2[NH1]C(Cl)=NC3=C2COC3 COC1=CC=C(C)C(C(=O)N2CCN(C(=O)C34CC(F)(C3)C4)[C@H1]5CC[C@H1]52)=C1 CC/C(C)=C/C(=O)N[C@@H1]1CN(C(=O)CC2CCSCC2)C[C@H1]1S(C)(=O)=O CCCC1=N[NH1]C=C1C(=O)N[C@@H1]2CN(C(=O)[C@@H1]3C[C@]3(C)Br)CC(C)(C)C2 C#CCOCCOCCOCC(=O)N[C@@H1](C)CN(C)C(=O)C1=CN(C)N=C1O CC[C@]1(C(=O)N[C@H1](CNC(=O)C2=CC=NN=C2NC(C)C)C3CC3)CCNC1=O C=C=CCCC(=O)N1CC[C@@H1](CCNC(=O)C2=NC(C)=CC=C2OC)C1 CCN(C)CCC(=O)N[C@@H1](CNC(=O)C1=CC=C(Cl)S1)C2=CC=CC=C2F C#CC1=CC=CC(C(=O)N[C@H1]2C[C@](C)(NC(=O)CN3CCCCCC3=O)C2)=C1C C[C@H1]1C[C@@H1]1C(=O)N2CCCC23CCC(NC(=O)C4=NC=C(Cl)C=C4Cl)CC3 CC=1N=NN(CC(=O)NC[C@@H1](NC(=O)C2([C@H1](O)C(F)(F)F)CCC2)C3CC3)N=1 C#CCCCCNC(=O)[C@H1]1CCCC[C@H1]1NC(=O)[C@@H1](C)C(CC)CC CC[C@](CO)(OC)C(=O)NC[C@@H1](C(=O)N1CC(C)(COC)C1)C(C)C CCOCCN1N=NN=C1[C@]2(NCC3=CC=NN3C(F)(F)F)CC4CCC2CC4 COC(OC)C(=O)N1CC[C@@H1](CCC(=O)N2CC=CC23CCOCC3)C1 C#CCCC(=O)NC(C)(C)[C@@H1](C)NC(=O)C1C[C@@H1]2CSC[C@H1](C1)C2(F)F CC(=O)NCC(C)(C)C(=O)N[C@@H1]1C[C@H1](O)[C@H1]1CC(=O)N[C@H1]2C[C@H1](O)C[C@@H1]2O CC(C)(CF)C(=O)N1[C@@H1](CC(=O)NCC[C@H1]2C[C@H1](F)C2)[C@H1]3CCC[C@H1]31 CC1=CC(F)=CC=C1CC(=O)N2CC[C@H1](NC(=O)C#C[C@]3(C)CCCO3)C2(C)C CCC1=NC=CN1CCNC(=O)[C@@H1]2C=CCN2C(=O)[C@H1](C)SC CCC1=NC(CC(=O)N[C@H1]2CN(C(=O)C3(C)CS(=O)(=O)C3)CC(C)(C)C2)=CS1 C[C@@H1](CO)C(=O)N1CCN(C)[C@@H1](C(=O)N(C)CC2=NN=C(O)O2)C1 CC(C)[C@@H1](CCNC(=O)C1=CN=CO1)NC(=O)C=2C=NN(C3CC3)C=2 CC(=O)C1=NC=C(C(=O)NC[C@H1]2CN(C(=O)COC[C@@H1]3CCCO3)CCO2)S1 NC1=CC(Cl)=NC=C1C(=O)N[C@H1]2C[C@@H1]2NC(=O)C3=CC=C(F)C(Cl)=C3F CC1(C(=O)N2CCC[C@@H1](N=[N+1]=[N-1])C2)CC(NC(=O)C=3N=NSC=3N)C1 C=C=CCCC(=O)N1CCN(C(=O)C2=CC=CC(=O)N2C)[C@@H1]3CCCC[C@@H1]31 CCCC1=CC=CC(C(=O)N[C@H1]2C[C@@H1]3C[C@H1](NC(=O)C[C@H1]4C=CCC4)[C@@H1]3C2)=C1 C#CC[C@]1(C(=O)NC2(CF)CC2)CCN(C(=O)C3=CN(C)[NH1]C3=N)C1 O=C(NCCC[C@H1]1CN(C(=O)C=2C=NN(C3CCC3)C=2)CCO1)[C@@H1]4[C@H1]5CCC[C@H1]54 NC1=CC(Cl)=NC(C(=O)N2C[C@@H1]3CC[C@H1]2[C@@H1](C(=O)NC4CSC4)C3)=C1Cl N#CC1=C[NH1]C=NC1=NCC[C@H1]2CCCN(CC3=CC=C4C=CC=C(O)C4=C3)C2 CCC1(C(=O)N2CCN(C(=O)C3=CSC=N3)[C@H1](C4=CC=CC(Cl)=C4)C2)CC1 C#CCN(C(=O)[C@H1](C)CSC)C1CCN(C2=NC3=CC=CN=C3S2)CC1 C=CC[C@@]1(NC(=O)C2=CC=C(S(N)(=O)=O)C=N2)CCCN(C(=O)COC)C1 CC1=NC=NC(C)=C1C(=O)N[C@@H1]2CC[C@H1](C)N(CCN3CCCS3(=O)=O)C2 CCOC(=O)[C@H1]1CN(CC2=CC=CC=3N=C(O)OC2=3)C[C@@H1]1C(=O)O C[C@]1(C#CC(=O)NC2(CCNC(=O)[C@@H1]3CCCCNC3=O)CC2)CCCO1 CC(C)[C@@](C)(O)C(=O)NC[C@H1]1CCC[C@@H1](NC(=O)C2=NN=CN2C)C1 CCCC(C)(C)C(=O)NCC[C@H1]1CCN(C(=O)[C@]2(N(C)C)CCCOC2)C1 CC1(C)CCO[C@@H1]1CC(=O)NCC[C@H1]2C[C@H1](NC(=O)C(F)(F)C3=CSC(=N)[NH1]3)C2 COC(=O)[C@@H1]1C[C@H1]1C(=O)NCCC2CCN(C(=O)C3=NC4=CN=CC=C4S3)CC2 O=C(CC=CC1=CC=C(F)C=C1)N[C@H1]2CCN(C(=O)C3=CON=C3C4CC4)C2 C[C@@H1](CC(F)F)C(=O)NC[C@@H1]1CN(C(=O)C2=CC=C(N)C=N2)CCO1 CC1=NC(N[C@@H1](CO)CNC(=O)[C@@H1]2[C@H1]3CC[C@@H1](C3)C2(C)C)=C(Cl)C=C1[N+1](=O)[O-1] COCC[C@@H1]1CCCCN1C(=O)CC2(NCC3=CC(F)=C(F)C=C3O)CCC2 CC=1N=NN(CC(=O)N2CC[C@H1](CNC(=O)C3=NN(C)C=C3[N+1](=O)[O-1])C24CC4)N=1 C[C@H1](C(=O)NC[C@@H1](NC(=O)C1=CC=CC2=C1NCCC2)C3CC3)C(C)(C)C C#C[C@@H1]1C[C@H1]2CC[C@H1]1N(C(=O)[C@H1]3CCN(C(=O)[C@H1]4COC(=O)N4)C3)C2 CC1=CC=NC=C1C(=O)NC[C@@H1]2CC3(CCN(C(=O)C4=CN=CO4)CC3)CO2 NC(=O)COC1CN(C(=O)C2=CC=CN=C2CC3=CC=CC(N)=C3)C1 C#CC1(C(=O)N2CC[C@@H1](O)[C@@H1](F)C2)CCN(C(=O)CCC3OCCO3)CC1 CCCC[C@@H1](NC(=O)COCCC(C)C)C(=O)NCCOC1=CC=CC=C1 C#CCCCCC(=O)N1CC[C@H1](NC(=O)C[C@H1](CC)C(F)F)C12CC2 O=C(CC1=CC=CC(Br)=C1)N[C@H1]2CN(C(=O)CN3CC=CC3)CC[C@H1]2CO CCN1N=C(C)C(C(=O)NC[C@H1]2CCCN2C(=O)[C@H1]3CCC4=NC=CN4CC3)=N1 O=C(NC1=CC=CC(F)=C1C(=O)N2C[C@H1]3COC[C@H1]3C2)C=4C=COC=4 CSC(C)(C)C(=O)N1CCC[C@H1](CCNC(=O)CCN2CCCC2=O)C1 CC(C)[C@H1](CNC(=O)[C@@H1]1[C@H1]2CC[C@@]1(C3=CC=CN=C3)C2)NC(=O)[C@H1]4C[C@@H1](C#N)C4 CS(=O)(=O)C1=CC=CC=C1CN2C[C@@H1]3C[C@@]3(C(=O)NC4=CN=CC(Cl)=N4)C2 CN1N=NC(C(=O)N2CCOC[C@@H1](NC(=O)CC3=CC=C4N=CSC4=C3)C2)=N1 O=C(N[C@@H1](CNC(=O)C1=C(Br)N=C2N1CCCC2)C3CCC3)C4=CN=C[NH1]4 C[C@H1](CNC(=O)C=1C=CC(=O)N(O)C=1)[C@@]2(O)CCN(C(=O)C3=CC=NC=N3)C2 CN(C)C1=NC(C(=O)NC[C@@H1]2CCCN(C(=O)C(C)(C)C3CCC3)CCC2)=CO1 C[C@@H1]1CC[C@@H1](NC(=O)C[C@@H1]2CCC3=CC=CC=C32)CN1C(=O)C4=CCSC4 C=CC(C)(C)CC(=O)N[C@@H1](C)CC1CN(C(=O)C[C@]2(C)CC2(F)F)C1 CC1=CC(N)=C(C(=O)NC[C@@H1]2CCN(C(=O)C3=C[NH1]N=C3C)C2(C)C)C(F)=C1 C=CC[C@@H1]C(=O)N1C[C@@H1](NC(=O)C2=CN=CC(F)=C2)[C@H1](OC)C1 CC(C)[C@@H1](CNC(=O)C1=CC=C2C(=C1)N=NN2CC)NC(=O)C3=C[NH1]N=C3F CCCC=CC(=O)N[C@@H1]1CCN(C(=O)[C@@H1](CC)CC(F)F)C[C@H1]1CC CSCCN1N=NN=C1C2(NCC3=CSC(C4=CC=CO4)=N3)CC(Br)C2 C[C@]1(CC(=O)N[C@@H1]2[C@H1]3C[C@@H1]2N(C(=O)C4=CC=C(O)C([N+1](=O)[O-1])=C4)C3)C[C@H1]1F NC(=O)[C@@H1]1CCCN1C(=O)[C@H1]2[C@@H1]3C[C@H1]2N(C(=O)C4=CC(F)=CC(F)=C4Cl)C3 C[C@H1]1CCC[C@@H1](C(=O)N2CCN(CCN(C)C(=O)C=3C=NN(C)N=3)CC2)CC1 CCC1=CC=C(C(=O)NCC2(CNC(=O)C=3C=NOC=3)CCC2)[NH1]1 C[C@@](F)(C(=O)NCC[C@H1]1COCCN1C(=O)C2=CC=C(F)C=C2N)C(F)(F)F CCN(CCC(=O)N1CC=2N=C(C)SC=2C1)C(=O)C=3C=C(CO)[NH1]N=3 O=C(N[C@H1]1C[C@](F)(CNC(=O)[C@H1]2COCCO2)C1)C3=CC(Br)=N[NH1]3 CN(C)C[C@H1](CC1=CC=CC=C1)NC(=O)C=2N=NSC=2N CCC(CC)C[C@H1](F)C(=O)N(C)[C@H1]1C[C@@H1](NC(=O)C=2C=NN(C(C)C)N=2)C1 CC[C@H1](C)[C@H1](CO)CNC(=O)[C@H1](CN1C=CC=N1)NC(=O)[C@H1](C)NC(C)=O O=C(C[C@H1]1CCN1C(=O)[C@H1]2CCCSC2)NOCCC(F)F CC1=CC=C(C(=O)N[C@H1]2CC[C@H1]2NC(=O)C(C)(C)CCF)C(O)=N1 CC=1C(C(=O)NC[C@@]2(NC(=O)[C@H1]3CCO3)CCCCO2)=NOC=1C4CC4 CNC(=O)N(C)[C@@H1]1CCCN(C(=O)C[C@@H1]2CCO2)C1 CC(C)CCC(=O)NCC(=O)NC[C@H1]1C[C@H1](O)[C@H1](O)C[C@H1]1C(=O)NOC(C)C CCOC(=O)[C@](C)(F)C(=O)N[C@@H1]1CCC[C@H1]1NC(=O)C2=CN=CN=C2C(C)C O=C(C[C@@]1(O)CCOC1)N[C@H1]2C[C@]3(C(=O)N(O)CCCO)CO[C@H1]2C3 C#CCCCCC(=O)NC[C@]12C[C@H1]1CN(C(=O)C(C)(C)CCCC)C2 CC1=CC(C(=O)N2CC(CCNC(=O)C3=C[NH1]C(C#N)=C3C)(OC)C2)=NC(C)=N1 C[C@@H1](NC(=O)[C@H1]1C[C@H1]1CNC(=O)CN2C=NN=N2)C3=CN=CS3 CC1=CN=NC=C1C(=O)N[C@H1]2CCC[C@H1](N(C)C(=O)C3=CC=CC4=C3CCC4)C2 CC(C)S(=O)(=O)[C@@H1](C)C(=O)N1[C@H1]2CC[C@@H1]1C[C@H1](NC(=O)CN3CCNC(=O)C3)C2 CNC1CCN(C2=NC(=NCCOC(C)C)[NH1]C3=CC=CC(F)=C23)CC1 CCC1=NC(COC2CCN(C(=O)C(=O)N3CC[C@H1](C)[C@@H1]3CC)CC2)=NO1 COC[C@H1](CNC(=O)[C@@H1](SC)C1CC1)NC(=O)CC2=CC=CC=C2Cl CN(C)[C@H1](C1=CN(C2CC(C(=O)NCC3COC3)C2)N=N1)C4CC4 C=C(C)C[C@@H1](OC)C(=O)N[C@H1](C)CN(C)C(=O)[C@@H1]1CC[C@H1](C(N)=O)C1 CC(C)(CC(F)(F)F)NC(=O)[C@@H1]1CC12CCN(C(=O)[C@]34C[C@H1]3CNC4=O)CC2 COC1=C(Br)C=CC(F)=C1C(=O)N[C@H1]2CCN(C(=O)C=3[NH1]N=NC=3C4CC4)C2 COC1=CSC=C1CNC2=CC(=NC3CCN(C4CCC4)CC3)[NH1]C(C(C)C)=N2 COCC=1C=CSC=1C(=O)N2CC(C)(C)OC3(C2)CN(C(=O)C=C(C)C4CC4)C3 CCN(CC)C/C=C/C(=O)NC1CCC(NC(=O)[C@H1]2C[C@]2(Cl)C(=O)OCC)CC1 CC[C@@]1(C)C[C@@H1]1C(=O)N2CC3(C)CC2(C(=O)NCC=4C(C)=NN(C)C=4C)C3 CCOC(=O)[C@@H1]1[C@H1](O)CCN1C(=O)C2=NC=CC(C(F)(F)F)=N2 CC1=CC=C([N+1](=O)[O-1])C(C(=O)N[C@H1]2C[C@@H1](F)CN(C(=O)CP(C)(C)=O)C2)=C1 C[C@@H1](CCNC(=O)[C@H1]1C[C@@H1](N2CCN(C)CC2)C1)N(C)C(=O)C(N)=O CC1=CC=C([C@@H1](C)NC2=CC=C(S(=O)(=O)N(C)CC=3SC=NC=3C)C=N2)O1 CC1=NC=C(C(=O)N2C[C@H1](CNC(=O)C3=CC=CC=C3)N4CC[C@H1]2C4)N1C CC/C=C/CC(=O)N1CC[C@H1](CC)C[C@@H1]1C(=O)N2CC(C)(C3CCC3)C2 C[C@@H1](CN1C=CC=N1)C(=O)N2CC(N3C=C(CNC(=O)[C@H1]4COCCO4)N=N3)C2 CCCC=CC(=O)N1CC2(CCOCC2)C[C@@H1]1CNC(=O)COC(F)F CC(C)CCCCC(=O)N1CCN(C(=O)C=2C=CN(CCF)N=2)[C@@H1]3CCCC[C@@H1]31 C=CC[C@@H1](CC(C)C)C(=O)N1CC2=C(C1)CN(C(=O)[C@H1](CCC)CC(C)C)C2 COC[C@](C)(OC)C(=O)NCC1(C(=O)N(C)CCN2C=NN=C2)CC1 COC1=CC(CO)=CC=C1C(=O)N[C@H1]2C[C@H1](NC(=O)C3=CC(SC)=C(C)O3)C2 CCC[C@H1](CNC(=O)[C@H1]1CCCCO1)C(=O)N[C@](C)(CC)C(F)(F)F CC1=CC=C(C(=O)N[C@H1]2C[C@@H1](F)CN(C(=O)C(C)(C)C=3C=CSC=3)C2)C=N1 CCO[C@H1](CC(=O)N1CC(CCNC(=O)[C@@H1](C)N2N=CC=C2C)C1)C(C)C C=CCN1C=C(C(=O)NC(C)(C)/C=C/C(=O)N[C@H1]2CCCC[C@]2(C)CO)C=N1 C[C@@H1]1C[C@H1]1CCC(=O)NC[C@@H1](C)N(C)C(=O)CC2(CCC3=CC=CC=C3)CC2 O=C([C@H1]1C[C@H1]2CC(=O)[C@@H1]1C2)N3CCO[C@H1](C(=O)NCC4CCCC4)CC3 CCOC[C@H1](C)C(=O)N1CC[C@@H1](CN(C)C(=O)C2=CC3=C(Cl)C=NC=C3S2)C1 CC1=CC(C(=O)N[C@H1](CC=2C=COC=2)C(=O)NCC3CCSCC3)=NS1 CN(C[C@@H1](O)CNC(=O)C1=CC(F)=CC=C1Br)C(=O)[C@@H1]2[C@H1]3COC[C@H1]32 C=CCC(F)(F)C(=O)NCC1(NC(=O)C2=CN=C(O)N2C)CCC(C)(C)CC1 CCC1=C(COCC(=O)N[C@@H1]2CN(C(=O)CCC3CCN(C)CC3)CC24CC4)ON1 C=COC1=CC=C(CN2[C@H1]3CC[C@H1]2CN(C(=O)CCCN4C=CN=N4)C3)C=C1 C=C=CCCC(=O)N[C@H1](CNC(=O)C1=N[NH1]C=C1F)C2=CC=CC=C2CC C=C(C)CC(=O)N1CC[C@@H1](NC(=O)CC2=CC=C3N=N[NH1]C3=C2)C[C@@H1]1C4CC4 CC1=CC=C(N2C=CC(C(=O)NCC3(O)CN(C(=O)[C@@H1]4CCC4(F)F)C3)=N2)C=C1 CCC(CC)[C@@H1](F)C(=O)N[C@@]1(COC)CCN(C(=O)C2(C)CCCCC2)C1 COC(=O)N1CCC[C@@H1]1C(=O)N[C@@H1]2CC[C@H1](CNC(=O)C3=NC=CC=C3F)C2 CN1C=NC(C(=O)NC[C@@H1]2CCN(C(=O)C3=CC=CC(C(N)=O)=C3)C24CCC4)=N1 CCC=1SC(C(=O)NC[C@@]23CCC[C@H1]2CCN3C(=O)CCCCC(N)=O)=CC=1C C[C@@H1](NC(=O)[C@@H1]1CN(C)CCO1)C2(O)CN(C(=O)C3=CC=C4N=C(S)[NH1]C4=C3)C2 CSC1=CC=C(C(=O)N2CCN(CCCNC(=O)CSC(C)C)CC2)C=C1 CCC[C@H1](CNC(=O)CC1(OCC)CCC1)C(=O)N2CC[C@H1](OC)[C@@H1]2C COCC[C@H1]1CN(C(=O)[C@H1]2CC(F)(F)C2(C)C)CCN1C(=O)CCCOC(C)C CC[C@H1](CNC(=O)C=1C=NN(CCO)C=1)NC(=O)C=2SC=CC=2N3C=CN=N3 CC1=NC(CC(=O)N2CC[C@@](O)(CN(C)C(=O)C3=COC(C(F)(F)F)=N3)C2)=CO1 C#CCC[C@@H1]1CCCN1C(=O)[C@@H1]2CCCCN(C(=O)[C@H1](CC)C/C=C/C)C2 CCC(F)(F)CC(=O)N1[C@H1]2CC[C@H1](C(=O)N(C)CCC[C@H1](C)O)[C@H1]1CC2 O=C(NCCOCCCNC(=O)[C@@H1]1C[C@H1]1C2=CC(Br)=CC=C2Cl)[C@@H1](O)C3CC3 CC1=NC(O)=NC(C)=C1C(=O)N2C[C@@H1]3CN(C(=O)C4=CN=C(O)C(F)=C4)C[C@@H1]3C2 C[C@]1(C(=O)N2CC(CCCCNC(=O)C3=CN=C(Cl)S3)C2)C/C=C/C1 CCCCN1C=C(C(=O)NC[C@@H1](CC)NC(=O)C2=C(F)C=CC3=C2OCO3)N=N1 CNC(=O)CCC(=O)N1C[C@H1]2C[C@@H1]1[C@H1]2C(=O)N(C)CC[C@@H1](O)CO C=C1COCCN(C2=CC=C(S(=O)(=O)N(C)CC3=CSC=N3)C=C2Cl)C1 C#CCCC(=O)N(C)[C@@H1]1CN(C(=O)[C@H1]2[C@@H1](C3=N[NH1]C(C)=N3)C2(C)C)CC1(C)C CCCC[C@@H1](O)C(=O)NCCCN(C(=O)[C@H1](CCOC)OC)C(C)C CCC(CC)(CNC(=O)CC(C)(C)C)NC(=O)CCCCN1C(=O)CCC1=O C[C@H1]1COCC[C@H1]1NC(=O)[C@@H1](CCC(N)=O)N2C=C(C3=CC=NC=C3F)N=N2 CCC1(C(=O)NC2=CC(C(=O)NCCF)=CC=C2OC)CCCC1 C#CCCCCC(=O)NC[C@H1](C(=O)NCC1=CC(Cl)=CC=N1)C(C)C COC1=CC=C(C)N=C1[C@H1](C)N[C@@H1]2CCC2=CC=C(Br)C=C CC1CN(CC(=O)NCC[C@H1](C)CCNC(=O)C[C@@H1](CNC=O)CC(C)C)C1 CCC1=C(NC(=O)[C@@H1]2C[C@H1]2C3CCN(C(=O)[C@@H1](O)C(C)(C)C)CC3)C=NN1CC COC1CC2(C1)CC(C(=O)NC3CC(CNC(=O)CO[C@@H1]4CCCOC4)C3)C2 CN(C)CCOC1=CC=C(C(=O)N[C@H1]2CCO[C@H1](C3=CC=CC(F)=C3)C2)C=N1 C[C@@H1]1C[C@@H1]1CC(=O)NC[C@H1]2CC3(CC3)CN2C(=O)CCN4C=NN=N4 C#CCCCCCC(=O)N[C@H1]1C[C@H1]2C[C@H1]1CN2C(=O)C=3C(C)=NOC=3C(C)C CC=1ON=C(Cl)C=1C(=O)N2CC[C@H1](CCNC(=O)C3=CN=C4C=CC(F)=CN34)C2 C=CCC(C)(C)C(=O)N(C)[C@H1](CNC(=O)C1=CC=NC(C)=C1N)C2CC2 COC1=CC=CC([C@@H1](CNC(=O)C2=CN=CN=C2C3=CC=CC=C3)N(C)C)=C1 CC(C)C1=CC(CNC(=O)COC2(C)CN(C(=O)[C@@H1]3CC[C@@H1]3C)C2)=NO1 O=C(CCCN1CCCCC1)N[C@H1]2CCOC[C@H1]2NC(=O)C3=CC=C(CO)N=C3 CC[C@H1](NC(=O)[C@H1]1CCC[C@H1]1NC(=O)C2(C(F)(F)F)CC2)C3=NC=NN3C NS(=O)(=O)CCCCNC(=O)COC(=O)C1=NC(N2CCCC2)=NC=C1Cl C#CCC1(C(=O)N2CC[C@H1](CCNC(=O)C3=CC(O)=NC(Cl)=C3)C2)CCCC1 CC1=CC=CC([C@H1](F)C(=O)NC/C=C/CC2=C[NH1]C3=CC=CC=C23)=N1 COC(=O)C[C@@H1](C)CC(=O)N(C)[C@@H1](C)CNC(=O)C=1N=C(Cl)SC=1Cl CC1=CC(C(=O)N[C@H1]2CN(CC3=CC=CC(C(F)(F)F)=C3F)C[C@@H1]2F)=N[NH1]1 O=C(CO[C@H1]1CCCOC1)N[C@H1]2CCC[C@H1]2N3CCN(C(=O)C4=CC=NS4)CC3 CNC(=O)[C@@]1(F)CCN(C(=O)CCC(C)(C)N(C)C)C1 CS[C@H1](CNS(=O)(=O)C1=CC=C(NCCSC2=CC=C(C)C=C2)N=C1)C3CC3 C[C@H1]1C[C@@H1]1C(=O)NC2=CC(O)=CC(C3=CC=C4[NH1]N=C(Cl)C4=C3)=C2 CC1=CC=C(C(=O)N2CCC[C@@H1]3[C@@H1]2CCCCN3C(=O)[C@H1]4CC4(C)C)C(Cl)=C1 C[C@@H1](SC1=CC=CC=N1)C(=O)N[C@H1]2C[C@@H1](NC(=O)C3=CN=C(N(C)C)S3)C2 O=C(NC1=CC2=CC=CC=C2S1)[C@H1]3CC[C@H1](NCC4=CC=C(F)N=C4)CC3 NC(=O)CCC(=O)N1CCC2=CC=CC=C2[C@H1]1CCNC(=O)C3=CN=NC=C3O CN(CC1=CC=CC=C1)C(=O)[C@H1]2C[C@H1]2C(=O)NC3=CN=NC(Cl)=C3 CN(C(=O)C1=CC=CC2=NC=NN12)[C@@H1]3C[C@H1]4C[C@@H1]3N(C(=O)C[C@]5(C)CCCO5)C4 COC1=CC=CC(CC(=O)NC[C@@H1](C)NC(=O)C2([C@H1]3CCCO3)CC2)=C1Cl CC[C@@]1(C(=O)N2CCC[C@H1](C(=O)NCC3=NC(C)=NO3)C2)CCOC1 CC1=CON=C1CC(=O)N[C@H1]2CC[C@@H1](C(=O)NCCC3=C[NH1]N=C3C)C2 C[C@@H1]1CCN(CCNS(=O)(=O)C2=CC=CC(=NC[C@@H1](O)CC3CCC3)[NH1]2)C1 O=C(NC[C@H1]1CCCCN1C(=O)C2=CC=C(Br)N=C2F)C3=CC=C(Br)C=C3 CC1=NN(C)N=C1C(=O)N[C@@](C)(CO)CNC(=O)C2=CN=NN2C3CC3 CC(C)(C(=O)NC[C@H1](NC(=O)C(F)F)C(C)(C)C)C1=C(F)C=CC=C1F C=CC[C@H1](CC)C(=O)N1CC[C@@](CC)(C(=O)NOCC=2C=C(C)ON=2)C1 CCCC[C@H1](CNC(=O)C=1C=CSC=1Cl)NC(=O)[C@H1]2C[C@@H1](N3CCCC3)C2 CCOC1=CC=C(C(=O)N2CC(O)(CNC(=O)[C@H1](O)CN3C=NC=N3)C2)C=C1Cl CC[C@@H1]1CCCC[C@H1]1C(=O)NCCCN(C)C(=O)C2=CC=CC=C2Cl CC1=NC(C2=CC=C(C(=O)NCC[C@@H1]3CSCCN3C(=O)CC4=CN=NS4)S2)=CS1 C=CCC[C@@H1](C(=O)N1CCCC[C@@H1](NC(=O)C2=CC=CN=C2N)C1)C3CC3 CCN(CC(C)(C)O)C(=O)CCCNC(=O)[C@H1]1C[C@H1]2C=C[C@H1]1C2 C[C@H1](C[C@@H1](C)C(F)F)NC(=O)[C@@H1](CNC(=O)CC1=CC=CC=C1O)N(C)C COC(=O)C[C@@H1](N[C@H1](C1=CC=CS1)C2=NN=NN2CCCF)C(C)C CC(C)(C#CC(=O)NC[C@@H1]1CNC(=O)C1)CNC(=O)C2(C#N)C[C@H1]3C[C@@H1]3C2 CC[C@H1](CCC(=O)NC[C@](C)(CO)NC(=O)C1=CC(C)=NC(O)=N1)OC C[C@H1](NC(=O)C(F)(F)C1=CC=CC=C1Cl)[C@H1]2CCCN2C(=O)[C@@H1](O)C3CCC3 C=C1C[C@H1]1C(=O)N[C@@H1](CC2=CC=CC=C2)CN(C)C(=O)C=3C=C(C(C)(C)C)ON=3 C=C[C@@H1]1OCCC[C@H1]1C(=O)N2CC[C@H1](CNC(=O)C=3C=NN4C=3CCCCC4)C2 CNCC1=CN(C[C@H1]2CCC[C@H1]2NC(=O)[C@@H1]3C[C@H1]4C=C[C@@H1]3O4)N=N1 CC1=CC=NC=C1[C@H1](C)NC(=O)C2(C)CCN(C(=O)CN(C)CC(C)(C)C)CC2 COC1=CC=C(Cl)C(C(=O)NCC(C)(C)NC(=O)C2=CC=C(F)C(F)=C2C)=N1 CC[C@H1](OC)C(=O)N1C[C@@H1]2C[C@H1]1[C@@H1]2NC(=O)C=CC(=O)N(C)C O=CNC1=CC=C(C(=O)N2CC[C@@H1](C3CN(C(=O)[C@@H1]4CCCNC4=O)C3)C2)C=C1 C[C@](O)(CNC(=O)C#CC1CCCC1)CNC(=O)[C@H1]2CN3CCC2CC3 C[C@@H1]1CCN(C(=O)C2=CC=C(O)C=N2)C[C@@H1]1NC(=O)CN3CC(C)(C)C3 CCC(=O)NCC(=O)N(C)[C@H1]1CCN(C(=O)C2=CC=CC3=C(Br)C=CC=C23)C1 C=CCN(OC)C(=O)C[C@H1]1CCN1C(=O)[C@H1]2CCCC(=O)C2 CC1=CC=NC=C1C(=O)N2CC3(CC[C@H1](NC4=NC=NC5=C4CCCC5)C3)C2 C=C[C@@H1](CO)NC(=O)[C@](C)(CSC)NC(=O)C1=CN(C)N=N1 COC[C@@]1(C(=O)NC2C[C@@H1]3CC(NC(=O)C=4OC=CC=4C)C[C@H1]3C2)CC=CCC1 O=C(N[C@@H1]1C[C@@H1]1CNC(=O)C2=CC=NC(C3CC3)=N2)C=4C=NN(CCF)C=4 CS[C@H1](C)C(=O)N1CC[C@H1](CNC(=O)CC2=NC=CC=C2C)C1(C)C CC1=CC=C(C(=O)NCC(=O)N[C@@H1]2CN(C(=O)[C@H1]3CC3(C)C)C[C@H1]2C)S1 CN1C=CC(C(=O)NC[C@@H1]2CCC[C@H1](CNC(=O)[C@@H1]3[C@H1](C(F)F)C3(C)C)C2)=N1 CC1=CC=C(CN(C)C(=O)[C@H1]2CC[C@@H1](O)CN2C(=O)C3=C[NH1]C(C#N)=C3)C=C1 CN(C[C@H1]1CCCN1C(=O)[C@H1](C2CC2)N(C)C)C(=O)C(C)(C)C3=CC=CS3 NC1=CC=CC(C=2N=C(C=3C=CN(C4=CC=CC(F)=C4)N=3)N(C5CCCC5)N=2)=N1 CCCOC(C)(C)C(=O)N[C@H1]1CN(C(=O)C2=CN=NN2C)CC3=NC=CN3C1 C[C@H1](O)[C@@H1](NS(=O)(=O)C1=CC=CS1)C(=O)NC2=CC=CC3=C2N(C)C(=O)O3 CC=1C=NN([C@H1](C)C(=O)NC[C@@H1]2CN(C(=O)C3=CN=C(C)S3)CC24CCC4)C=1 C[C@@H1]1C[C@@H1]1NC(=O)[C@H1]2CC3(CCN2C(=O)CO[C@@H1]4CCCOC4)CC3 C[C@H1](N[C@@H1](C)C1=CC=NC=C1F)[C@H1](C2=CC=CC=C2)N3CCOCC3 C[C@H1](CC(=O)NCC1(O)CCN(C(=O)C2=C[NH1]C(C#N)=C2)CC1)N(C)C CC(C)OC1=CC(F)=CC(NC(=O)[C@H1]2C[C@@H1](O)C2)=C1 CC(C)(C)[C@H1](O)CCC(=O)NC[C@@H1](CO)NC(=O)CC1(O)CCCC1 CC1=NN(CC(=O)NC[C@H1]2CCN(C(=O)[C@@H1]3[C@H1]4CCC[C@H1]43)CC2(F)F)C(=O)O1 CCCCCCN(C)CC(=O)N[C@@H1]1CCCN(C2=NC=NC(Cl)=C2C(C)=O)C1 O=C(C1=CC=NN1CC(F)F)N2C[C@@H1]3C[C@H1](C2)CN3C(=O)C[C@@]4(O)CCOC4 C[C@H1]1CC(C(=O)N2CCC(C3(O)CCN(C(=O)C4=CCSC4)CC3)CC2)=NO1 CCCN1N=CC(C(=O)N[C@@H1]2CN(C(=O)[C@](CC)(CO)OC)CC2(C)C)=C1C CC=1C=C(C(=O)NC[C@@](C)(CO)NC(=O)C2CC3(CCC3=O)C2)SC=1Cl C[C@H1](C1=CN=CC=N1)N2CC[C@@H1](NC(=O)C3=CC=C(Cl)C=C3)[C@H1](C)C2 N=C1C=CC(CCC(=O)NCCC2CN(C(=O)[C@@H1]3C[C@@H1]4C=C[C@H1]3CCC4)C2)=C[NH1]1 C#CC1=CC(Br)=CC(C(=O)NC[C@H1]2C[C@H1]2NC(=O)CCC3=CC=C(C)C=C3)=C1 CN(C)CCCCCC(=O)NC[C@@H1](CO)NC(=O)C1=CC(F)=C(F)C=C1O C#CCN(C(=O)/C=C/CN(C)C(=O)[C@@H1](CCC)N(C)C)C1CC(C#N)C1 CC#CC[C@@H1](NC(=O)C=1ON=CC=1CC)C(=O)NCCC#CCC CC(C)=CC(=O)NC[C@@H1]1CN(C(=O)C2(N(C)C)CCOCC2)CCN1C CC1=CC=C(C(=O)NC[C@@H1](NC(=O)C2=CN=CC(Cl)=C2)C3CC3)C=C1F CN(CCNC(=O)[C@@H1]1CCC2=NN=NN2CC1)C(=O)[C@H1]3CC4=CC=CC=C4O3 O=C([C@H1]1S[C@H1]2C=C[C@H1]1CC2)N3CC[C@H1](C4CC4)[C@H1]3CN5C=C(CCCO)N=N5 CN(C(=O)C1=CC(C2(C)CC2)=N[NH1]1)[C@@H1](CNC(=O)[C@@]34CCCN(CC3)C4)C5CC5 CCC1(CN=C2C=C(NCC3=CSC(COC)=N3)N=C[NH1]2)CC1 O=C(C1=CC=C(CC2CC2)S1)N3C[C@@H1](CO)C4(CNC4)C3 COCC[C@@H1]1CCCN([C@H1](C(=O)NCC(F)F)C=2C=C(C(=O)OC)SC=2C)C1 COC1=CC=C2C(=N[C@@H1]3CSC[C@H1]3C)[NH1]C(=NCC4=CC=C(N)C=C4F)[NH1]C2=C1 O=C(C=1C=C[NH1]N=1)N2C[C@@H1]3C[C@H1](C2)CN3C(=O)CCC4=CC(Cl)=NO4 C[C@@H1]1C[C@@H1](CNC(=O)CCC2(C)CC2)CCN1C(=O)C3=CC(F)=CC=4N=C[NH1]C3=4 CC1=CSC(=O)N1CC(=O)N2CCN(C(=O)CC3=CC=CO3)C[C@@H1]2C CC=1C=C(C(=O)N[C@]2(C3CC3)CCN(C(=O)[C@@H1](C)OC)C2)SC=1Br C=CCSCC(=O)NCC=1C=NN2C=1CN(C(=O)[C@@H1](CC)[C@@H1]3CCCO3)CC2 CC1=CC(C(=O)CN2CCOCC(C)(C)C2(C)C)=NS1 CC(C)(C#N)CC(=O)N1CCN2N=CC(C3=CC=CC=C3OC(F)(F)F)=C2C1 C[C@H1](CNC(=O)CC1=NC(C2CC2)=N[C@H1]1C)N(C)C(=O)C=CC3CCCCCC3 CC1=C(C#N)C=CC=C1C(=O)NC[C@H1]2CCCCN(C(=O)CC(C)C)C2 O=C(COC1=CC=C(Cl)C(Cl)=C1)N[C@H1]2C[C@H1](NC(=O)[C@@H1]3CC[C@H1]3CF)C2 CCC(C)(C)NS(=O)(=O)C1=CC=C(C(=O)OCC)C=C1NCC2=CC=C(C)C=C2 CCSCCC(=O)NC[C@@H1]1CCC[C@H1](CNC(=O)[C@@H1](CC)OC2CCCCC2)C1 CC1=NC2=CC(C3=CN=C4C=CC(C(=O)N5CCC[C@H1](O)C5)=CN34)=CN=C2[NH1]1 CO[C@@H1](CC1CCCCC1)C(=O)NCC2CN(C(=O)C3=CN=CC(Cl)=C3C)C2 CNC1CN(C2(C(=O)N3CC[C@@H1]4CN(C(=O)C5=CC(F)=CN5C)C[C@@H1]4C3)CC2)CC1 NC1=CN=CC=C1C(=O)N[C@@H1]2C[C@H1](C(=O)N3CCCNC(=O)CC3)C[C@H1]2O CC1=CC(N2CCC[C@H1]([C@@H1]3C[C@H1]3NC(=O)C(C)(C)CF)C2)=C([N+1](=O)[O-1])C(C)=N1 O=C(CC[C@@H1]1CC1(Cl)Cl)NC[C@H1]2CN(C(=O)C3=CCCOC3)C[C@H1]2O COC1=CSC=C1C(=O)NC[C@H1](CCNC(=O)C=2OC=C3C=2CCCC3)OC CC[C@H1]1C[C@@H1](C(=O)N(C)CCOCCN(C)C(=O)CCOCC(C)C)CCO1 C=CCCC1(C(=O)NC[C@H1](CC(=O)N(C)[C@H1](C)C(=O)OC)OC)CC1 CCN1N=NC=C1C(=O)N[C@@H1]2CCN(C)[C@]23CCCN(C4=NC=NC=C4Cl)C3 CCC[C@H1](C(=O)N1CCN(C(=O)CCC=2N=C[NH1]N=2)[C@H1](CO)C1)N(C)C CC(=O)N1CC[C@H1](NC(=O)C[C@]2(C)CCN2C(=O)C3=CC(F)=CC(F)=C3)C1 CC1=CC=NC(C(=O)N2C[C@H1](C(=O)N(C)C[C@@H1](C)C(F)(F)F)CC[C@@H1]2C)=C1N CCCC(CCC)C(=O)NC[C@]1(C)CCCN(C(=O)C=2C=CSC=2OCC)C1 CCN(C(=O)C[C@@]1(C)CCN(C(=O)CC(=O)OC)C1)[C@H1](C)C(=O)OC CCC[C@H1](NC(=O)C1=CC=CC(CC)=N1)C(=O)N[C@@H1]2CN(C(C)C)C[C@H1]2C CC1=NN=NN1C2=CC=CC(NC(=O)NC3=CC=C(N4CCCS4(=O)=O)C=C3)=C2 CC1(NC(=O)C2=CC=C(Br)C=C2)CC(NC(=O)[C@]3(CO)CC3(F)F)C1 C[C@H1]1CCN(C(=O)C(C)(C)C2=CCSCC2)[C@@H1]1C3=CN(CC4=CC=CC=N4)N=N3 CC[C@@H1]1CN(C(=O)C2=CC=CC=3SN=CC2=3)CC[C@@H1]1NC(=O)CCCC(F)(F)F C#CCOCCOCCOCC(=O)N1CCC2(CC1)CN(C(=O)C=CCC)C2 CC(=O)[C@H1]1[C@H1](C(=O)N2[C@H1](C(=O)NC3CCN(CCO)CC3)C[C@@H1]4C[C@@H1]42)C1(C)C CN1C=C(NC(=O)CCCNC(=O)[C@H1]2C[C@H1]2C(F)F)C(C#N)=N1 O=C(NCC=C1CCN(C(=O)CCOC2CCC2)CC1)C3=NC=CN4C=CN=C34 C[C@]1(C(=O)N2CCC[C@H1]3[C@@H1](CCCN3C(=O)C=C4CCC4)C2)CCCO1 C[C@@H1](CNC(=O)NC1=CC=C(N2CCC(N(C)C)CC2)C=C1)C3CC3 CC[C@H1](SC)C(=O)NCCN(C(=O)C[C@H1]1C[C@@H1]1C2CC2)C3CCCC3 CO[C@H1](CC(C)C)C(=O)NC1([C@H1]2CCCN(C(=O)C3=C(O)C=CC=C3Cl)C2)CC1 COC[C@@H1](C)C(=O)N[C@@H1]1CN(C(=O)C(C2CC2)C3CC3)C[C@H1]1SC CC1=CC=C([C@@H1](NC2(CCF)CC2)C3=NN=NN3CCC4(C)CC4)C=N1 CN(CCN1CCCC1)C(=O)C2=C[C@@]3(CCN(C(=O)[C@@H1]4COC[C@H1]4C(N)=O)C3)C2 C[C@@H1]1CN(C(=O)C=2N=NN(C)C=2N)C[C@@H1]1NC(=O)C=CC3=CN=CS3 C#CCOCCC(=O)NC[C@@H1](C)[C@@]1(O)CCN(C(=O)CC2=CC(Cl)=CS2)C1 CCN1C=CC(CCNC(=O)NC[C@H1]2C[C@H1](C3=CC=CC=C3)CO2)=N1 C#CCCC(=O)N1CCN([C@@H1]2COC[C@H1]2NC(=O)C3=C[NH1]C(C(F)(F)F)=C3)CC1 C=CCC[C@@H1](CC(C)C)C(=O)NC[C@@]12C[C@@H1]1CN(C(=O)C3=CC(C)=C(C)[NH1]3)C2 CC(C)[C@H1](NC(=O)C1=CN2C=CC=CC2=N1)[C@@H1](NC(=O)CC3CC3)C4=CC=CS4 COCC1=CC(C(=O)N[C@@H1]2CCC[C@@H1]2NC(=O)CN3N=C(C)C=C3C)=NO1 CC[C@@H1]1CN(C(=O)C=2C=COC=2C)CC[C@H1]1NC(=O)C3=CC(SC)=C(C)O3 COC[C@]1(C(=O)N2CCCC[C@]23C[C@H1](NC(=O)C=C4CCN(C)C4)C3)CCOC1 C[C@@H1](C1=CC=CC=N1)N2CC[C@@](N)(C(F)F)C2 CC(C)[C@H1](O)CC(=O)N1[C@H1]2CCC[C@H1]1CN(C(=O)C=C3CN4CCC3CC4)C2 O=C1CC[C@@H1]1C2=CC=C(NC(=O)C3CCCC34OCCO4)C=C2 CC[C@@]1(C)C=C(C(=O)N(C)C2(C(=O)N3CCO[C@](C)(CC)C3)CC2)C1 CCN1N=CC(C(=O)N[C@H1]2[C@@H1]3CN(CC(=O)NC4=CC=CC(C)=C4C)C[C@@H1]32)=C1C C[C@]1(C(=O)NCCOC2CN(C(=O)C3=CC=CN=C3C4CC4)C2)C[C@H1]1C(F)(F)F C#CC(C)(C)C(=O)N1CC(C=C)(CC(=O)N[C@H1]2CC(=O)N(C)[C@@H1]2C3=CC=CC=C3)C1 CSC[C@H1](NC1=NCCCN1C)C2=CC=C(OC(F)(F)F)C=C2 C=C(C)CNC(=NCCC1=CC=CC=C1Cl)N(C)CC=2OC=CC=2C O=C1CC[C@H1](C(=O)NC23CC(C2)N(C(=O)[C@@H1]4C[C@H1]5C[C@@H1]4CC5(F)F)C3)CN1 CC[C@@H1]1C[C@@H1](C(=O)OC)CCN1C(=O)C(=O)NCC23CCC(CC2)C(C)(C)O3 CCO[C@@H1](C(=O)N(CCN(C)C(=O)C=C1CCOCC1)C(C)C)C2CC2 C=C=C[C@H1](C)C(=O)NCCN(C(=O)C1=CC(C#N)=CN1C)C2CCCCCC2 COCC1(CC(=O)N[C@@H1](C)CN2C=C(C[C@@H1]3CCOC3=O)N=N2)CCOCC1 CCCN1C=CC(=NC(=O)[C@@]2(NC(=O)CC(COC)COC)CCSC2)[NH1]1 CN1CCO[C@@H1](C(=O)NCC2(C(=O)NC3=CC=CC(O)=C3F)CCCC2)C1 CN(C(=O)C1=CN=CC=C1Cl)[C@@H1]2CCCC[C@@H1]2NC(=O)CS(=O)(=O)NC3CC3 COCN1N=CC=C1C(=O)N2CCN(C(=O)C3=NC(O)=NC(O)=C3F)C[C@@H1]2CF CCC=1C=NOC=1C(=O)N[C@H1](C(C)C)[C@H1](C)NC(=O)C(C)(C)C2=CSC=N2 C[C@@H1]([C@H1](C)C(=O)NCC1(CNC(=O)C2(C)CC2)CCC1)S(C)(=O)=O CC[C@@H1](CC(=O)N1CC2(C[C@@H1](NC(=O)CCN3C=CC=NC3=O)CO2)C1)SC CC1=CC(C2)=CC(N)=C(C(=O)N3[C@@H1]C[C@H1]4[C@H1]C(=O)O[C@@H1]43)SC2=N1 C#CCN(CCC(=O)NCC(C)(C)[C@@H1](C)O)C(=O)C=1C=C[NH1]C(=N)N=1 O=C(NCC1=CC=CC=2SC=CC1=2)N(CCO)CC3CCCCC3 C[C@@H1]1CC[C@H1](C(=O)N2CC[C@H1](CC(=O)N3CCC4=NOC=C4C3)C2)N1C CC(C)(CNC(=NCCF)N1C[C@@H1]2[C@@H1](CF)[C@@H1]2C1)C3=CC=CC(Cl)=N3 C=C[C@@H1]1C[C@H1]1C(=O)NC[C@H1]2C[C@@H1](NC(=O)C3=CN(CCO)N=N3)C2 CCOC(OCC)C(=O)N1CCC[C@]1(CC)C(=O)NCC2=CN(C)C=N2 C=CC[C@H1](C(=O)NCC1=CC=C(C(=O)N[C@H1]2CCC[C@@H1]2C#N)O1)C(C)C CC(C)N1N=CC=C1C(=O)N[C@]2(CF)CCN(C(=O)C3=CC(Cl)=NC=C3O)C2 CN(C(=O)[C@@H1]1CCOC(=O)CC1)[C@H1]2CN(C(=O)C3=CC=CC=C3Br)CC24CC4 C=CC[C@H1](CC)NC1=NC=CC=C1S(=O)(=O)NCCCC2=CC=CC=C2C CCOC(=O)C1(C2=CN(CCC=C(C)C)N=N2)CN(C(=O)[C@H1]3CC=CCC3)C1 C=CCO[C@H1](C)CNC(=O)[C@H1](F)C1CC(NC(=O)C2=CN=CN=C2)C1 O=C(C#C[C@H1]1CCOC1)NC[C@H1]2CN(C(=O)C#CC3CCC3)CC24CCC4 CN1N=C2C(=C1[C@@H1]3C[C@@H1]4C[C@H1]3N(C(=O)C5=CC=C(S(N)(=O)=O)O5)C4)COCC2 O=C(CN1C=NC=N1)NCC2=CN(C[C@H1]3CCCN3C(=O)C4=CCOCC4)N=N2 CC1=CC=NN1[C@@H1](C)C(=O)N2CCOC[C@@H1]2CC(=O)N3CCC[C@](O)(C4CC4)C3 NC(=O)CCC1=CC=CC(OCC(=O)N[C@H1]2CC[C@](O)(C3=CC=CC=C3F)C2)=C1 CCC1=CN2C=C(C(=O)N3C[C@@H1](NC(=O)C4(C(F)F)CCOCC4)C[C@@H1]3C)N=C2C1 CCCC=CCCNC(=O)[C@@]1(CC)CCCN1C(=O)CN2C=CC=N2 CC[C@@H1](CN1C=NC=N1)NC(=O)C2(CCNC(=O)CC3=CN=CN3C)CCCC2 CCN1N=NC(C)=C1C(=O)N(C)CCNC(=O)C(F)(F)C2=CC=C(Cl)C=C2 CC=1SC(NC(=O)C(=O)NCC2[C@@H1]C3C[C@@H1]23)=NC=1C4=CC=C(F)C=C4 CCC1=NC=C(C(=O)N2CCC[C@@](O)(CN(C)C(=O)C#C[C@@H1]3CCCOC3)C2)S1 C[C@@H1]1CN(C(=O)[C@@H1]2CC(=O)CO2)CC[C@@]13CCOC3 C#CC1=CC=CC(C(=O)N[C@@H1]2CN(C(=O)[C@H1]3CCN4N=NN=C4C3)C[C@@H1]2C)=C1Cl CC[C@H1](CCC(=O)N[C@H1](C)C(=O)N[C@@H1]1CC[C@H1]2C[C@@H1]1CO2)OC CCN1CC(NC(=O)[C@@H1]2CCN(C(=O)C3CC(OC)(OC)C3)[C@@H1](CO)C2C)C1 CN1CC[C@H1](N(C)CCC2=CC(F)=CC(F)=C2)C1 CN1N=NC(C(=O)N[C@H1](CNC(=O)CC(C)(C)C2CC2)[C@@H1](O)C3CC3)=C1N COCC(=O)N1C[C@@H1](C(=O)N[C@@H1](C)C(=O)NC2CC2)C3(CC3)C1 C=C(Cl)CCC(=O)N1CCCC[C@H1]1CN(CC)C(=O)CC[C@H1](C)S(C)(=O)=O NC(=O)C=CC(=O)N[C@@H1]1CN(C(=O)[C@@H1]2CCCCN2CC(F)F)CC[C@H1]1C(F)(F)F CC1=C(Cl)C=CC=C1C(=O)NCCC[C@@H1]2CCCN2C(=O)C=CC3=CC=NC=N3 CC1=CC=C(C(=O)N[C@@H1]2CS(=O)(=O)C[C@H1]2NC(=O)C(F)(F)C3=CC=CC=C3)N1C NC(=O)C=1C=NSC=1NC(=O)C2=N[NH1]C3=CC(C4=CN=CC(F)=C4)=CC=C23 CCC1=CC=C(C(=O)NC[C@H1]2CN(C(=O)C=CC3=CC=CN3C)C[C@H1]2C)C=C1 CO[C@@H1]1CN(C(=O)C(F)(F)C(F)(F)C(F)F)C[C@H1]1NC(=O)C2=CN=C(Cl)[NH1]2 CC1=CC(=O)N(C)C=C1NCC2=CC=CC(OCC3=CC=CC=C3)=C2 CC[C@H1](CNC(=O)COCC1=CC=C(C)C=C1)NC(=O)CN2C=C(C#N)C=N2 N#CC1=CC(C(=O)NC/C=C/CNC(=O)[C@H1]2C[C@H1]2C(N)=O)=C[NH1]1 CCC1(C(=O)NC[C@H1]2CC[C@@](F)(CNC(=O)[C@H1]3C[C@]3(C)COC)CC2)CCC1 C=CC[C@]1(NC(=O)C2=CC(OC)=NC=N2)CCN(C(=O)[C@H1]3CC[C@H1]3C#N)C1 CC1=CC=CN(CC(=O)N[C@H1](C)[C@@H1]2CCN(C(=O)C=3C=C[NH1]C=3)C2)C1=O CC(=O)N(C)[C@@H1](C)C(=O)N1CC=C[C@@H1](NC(=O)CN2C=C(C3CC3)N=N2)C1 CCCCC(=O)NC[C@@H1]1CCCCN1C(=O)C2=CC=CC(N(C)C)=C2 CCN1C=CN=C1CNC(=O)C2=CC=CC(NC(=O)C3=CC=CC=C3)=C2 CCOCC(=O)N[C@@H1](C)[C@H1]1CN(C(=O)CSC2=N[NH1]C(C)=N2)CCO1 NC(=O)[C@@H1]1C[C@@H1]1C(=O)N2CC[C@@H1](NC(=O)C3=CC=C(F)C(F)=C3F)[C@H1](CO)C2 CC(C)OC1=CC=CC([C@H1](C(=O)NC2CC(F)(F)C2)NCCCC)=C1 C[C@@H1]1CCO[C@@H1]1C(=O)NC[C@@H1](F)CNC(=O)COCCCF CC(C)(C)CCCCC(=O)N1CC[C@@](C)(NC(=O)C2=CC=C3C(=C2)C(=O)NC3)C1 O=C1CC[C@H1](CC(=O)N[C@]2(CF)CCN(C(=O)CCCC3CCCC3)C2)C(=O)N1 CC(C)N(C)CC(=O)N1CCC(C)(C)[C@H1](CNC(=O)C2=NO[C@@H1](C(C)(C)C)C2)C1 CCCOC1=CC=C(Br)C=C1N[C@H1](CN2CCCCCC2=O)C3=NN=NN3C(C)C COCC[C@H1](CNC(=O)C1=CC=C2C(=C1)CCOC2)NC(=O)C3=COC(Cl)=N3 C=C(C)CN1N=NN=C1[C@@H1](NCC2(C3CC3)CCC2)C4=CN=CN=C4 CC1=CC(C(=O)N2CCCC[C@]23C[C@H1](NC(=O)CN4[NH1]C=NC4=N)C3)=NC(O)=N1 C[C@@H1]1CC[C@H1](CN[C@]2(C3=NN=NN3C(C)(C)C)CCCO[C@@H1]2C)C1 CN1C[C@](C)(C(=O)N[C@@H1]2[C@H1]3C[C@@H1]2N(C(=O)COC4CCCC4)C3)CCC1=O CC1=CC(C)=C(C(=O)NCC#CCNC(=O)C[C@H1]2CCC[C@H1](C#N)C2)C=C1C CCCN(CC(F)F)C(=O)C1CC(N(C)C(=O)CCC=C(C)C)C1 CSC[C@H1](O)C(=O)N1CC2(CN(C(=O)C3=CC=CC(CCCCO)=C3)C[C@@H1]2C)C1 C=C[C@@H1](O)C(=O)N1CCC(CCOC)(NC(=O)C2=CC=CN2CCC)CC1 COC1=C(C(=O)N[C@H1](CNC(=O)C(F)(F)C2=CSC(Cl)=C2)C(C)(C)C)C=NN1C C[C@@H1]1[C@H1](NC(=O)CC2CC2)CCCN1C(=O)[C@@H1]3CC(C4=CC=CC=C4[N+1](=O)[O-1])=NO3 C[C@H1](NC(=O)[C@H1]1CCC[C@@H1]1O)[C@@]2(O)CCN(C(=O)[C@H1]3C[C@@H1](N4CCOCC4)C3)C2 CC1=CC(O)=NC(C)=C1C(=O)N[C@H1]2COC3(CNC(=O)[C@@H1]4CCCO4)CC2C3 C=CCCOCC(=O)N[C@@H1]1CCN(C(=O)C(C)(C)OC(C)=O)C[C@H1](O)C1 CCC1=CN=C(CNC(=O)C2=COC3=C2CN(C(=O)[C@@](C)(F)C=4C=CON=4)C3)[NH1]1 CC1=C[C@H1](C(=O)N2CC[C@H1]3[C@@H1](C2)[C@@H1]3NC(=O)C45CCC(CC4)C5)SC1 CC1=NN=CC=C1C(=O)N2CC[C@@H1](C)[C@H1](CC(=O)NCCC=3N=CON=3)C2 O=C(N[C@H1]1COC[C@H1]1NC(=O)[C@H1](F)N2C=CN=C2)C3CCS(=O)CC3 CCOCCOCC(=O)N1CC[C@@H1](NC(=O)C2=NC=CC=3C=C[NH1]C2=3)[C@@H1](F)C1 CC(C(=O)N1CC[C@H1](OCCNC(=O)C2=NN(C)C=C2N)C1)=C3CC3 O=C(CCC1=NC=C[NH1]1)N[C@]23CCCN(C(=O)C4CCC5(CCC5)CC4)C[C@H1]2C3 CCCC=C(CC)C(=O)NC(C)(C)CCC(=O)N1CCC[C@H1]1CC2CC2 CC1=CN=CC(C(=O)N2CCC[C@@](O)(CN(C)C(=O)[C@@H1]3C[C@H1]3C(C)(F)F)C2)=C1Cl COC1=CN=C(Cl)C=C1C(=O)N2CC[C@](C)(CCNC(=O)[C@H1](F)CC3CC3)C2 C#CC[C@@](C)(NC(=O)C1CC2(CC2)C1)C(=O)NC[C@H1](C)CN(C)C CN(C)C(C)(C)C(=O)NC[C@H1](CNC(=O)[C@@H1]1CCCC2(CCC2)C1)C(F)(F)F CC1=NOC(C)=C1[C@@H1](C)CNC(=O)[C@H1](C)N2CCOC2=O C[C@@H1]1COC[C@H1](CC(=O)N[C@@]2(C(=O)NCCC3=NC=CC=N3)CCSC2)O1 CCC(CC)N1C=CC(C(=O)NC[C@@H1](C)CNC(=O)[C@@H1]2CCCN(CC)C2)=N1 CO[C@@H1]1CN(C(=O)COC=2C=NN(C)C=2)C[C@@H1]1NC(=O)C3=NN(C)C=C3C(C)=O CCC[C@@H1](C(=O)NC[C@@H1]1C[C@H1]1CNC(=O)C2=C(OC)C=NN=C2OC)C(=O)OC CN(CC1CN(C(=O)C[C@H1]2CCCN2C(=O)OC(C)(C)C)C1)C3=NC=CC(Br)=N3 C[C@@H1]1CN(C(=O)[C@@H1]2C[C@H1]3C=C[C@@H1]2C34CC4)C[C@H1]1CNC(=O)[C@H1]5CCC6(CC6)C5 O=C(C1=NOCC1)N2CCC(N3CCOC4=CC=CN=C43)CC2 CN1CC(CN(C)C(=O)[C@H1]C2C[C@H1](CNC(=O)CCC3(C#N)CCC3)CC2)C1 N=C1N=C(C(=O)N2CC[C@@H1]2CC(=O)N3CC[C@](O)(C(N)=O)C3)C=C[NH1]1 COCCN(C(=O)[C@@H1](O)CN1C=NC=N1)C2CCN(C(=O)[C@H1]3CCC4(CC4)C3)CC2 C#CCOCCC(=O)N1[C@H1]2CC[C@H1]1[C@@H1](C)[C@@H1](NC(=O)C3=CC(C)=NC(OC)=C3)C2 CN1C=NC2=C1CC(=O)N2CC3=CN(CC4CC4)N=N3 CN1C[C@H1](O)C[C@@H1]1C(=O)N2CC3(CC(NC(=O)C4=CN=C(C5OCCO5)S4)C3)C2 CC(C)CN1CCN(C(=O)C2=CC3(CN(C(=O)C4=C(Cl)CCC4)C3)OC2)CC1 CCO[C@@H1](C)C1=NC=C(C(=O)NCC2CN(C(=O)C[C@H1]3CCCCO3)C2)S1 CC1=NSC=C1CC(=O)N[C@H1](C)CC2CN(C(=O)[C@H1]3CC[C@@H1]3C4=CC=CC=C4)C2 CC1=NC(C2=CC=C(OC(=O)C3=CC=C(S(=O)(=O)C(C)C)C=C3)C=C2F)=NO1 CC(C)(C)C1CCC(N)(NC(=O)C2=CC(C#N)=C(O)N=C2N)CC1 C=CC1(CC(=O)N2CCN(C(=O)C3=CN=C([C@@H1]4CCOC4)S3)CC(C)(C)C2)CC1 CO[C@@H1](C(=O)NC1(C(C)(F)F)CCC1)C2CN(C(=O)CC3=CN=NS3)C2 COC1=CC(O)=CC=C1C2=NC([C@@H1](C)C3CC3)=NN2C4=CC=C5C(=C4)CCO5 CCC(C)(C)[C@@H1](O)C(=O)N1CCN(C(=O)C2=CC3=CC=C(Cl)C=C3O2)C[C@H1]1C C=C(C)[C@H1]1OCC[C@H1]1C(=O)NCC2=CN(C[C@H1]3CCCC3(F)F)N=N2 C[C@H1]1C[C@H1](NC(=O)CN2C=CC=C(N)C2=O)CCN1C(=O)CC(F)(F)F O=C(NC1([C@H1]2CCCCO2)CC1)[C@H1]3C[C@]34CCN(C(=O)CCOC5CC5)C4 CNC(=O)CCN=C(NCC1(C(C)(F)F)CC1)N[C@H1]2C[C@H1](C3=CC=CC=C3)C2 CC[C@]1(C)C[C@@H1]1C(=O)N2CCC3(CC(C(=O)N4CC(CC5=CC=CO5)C4)C3)C2 C[C@H1]1CCO[C@@H1]1CC(=O)NC(C)(C)C[C@@H1](F)C(=O)N2CC(C3=NN=CS3)C2 CCC1=NON=C1C(=O)NC[C@](C)(O)CNC(=O)C(C)=CC2=CC=CO2 CC(C)SCC(=O)N1CCCC[C@H1](C2CN(C(=O)[C@@]3(Cl)CC3(F)F)C2)C1 O=C(N[C@@H1]1CC[C@H1](NC(=O)C2CC(CCO)C2)C1)C3=CC=C4C=CSC4=C3 CN1C=NC=C1C(=O)NC[C@@H1]C2N(C(=O)CC3=N[NH1]C4=CC=CC=C34)[C@@H1]5C[C@H1]25 CC(C)(C)[C@@H1](C(=O)NC1CCCCC1)N2C=C(CCC=3N=N[NH1]N=3)N=N2 COCC[C@@H1](NC(=O)[C@H1]1CCC(=O)N1)C(=O)NCC2=CN=NC(C)=C2C C[C@H1](NC(=O)C1C[C@@H1]2COC[C@H1]2C1)[C@H1]3CCCCN3C(=O)CCOCC(C)(C)C CC[C@](C)(O)C(=O)NCCNC(=O)C1CN(C(=O)C[C@@H1]2CC[C@@H1](C)CO2)C1 CC[S@@](=O)CC(=O)N[C@H1]1C[C@@H1](CCNC(=O)[C@@H1]2CC(C3=CC=CC=C3)=NO2)C1 CO[C@@H1](CO)C(=O)N[C@H1]1CN(C(=O)C2(CO)CC2)C[C@H1]1C CO[C@H1]1C[C@@H1](CNC(=O)[C@H1](C)C2CCCC2)N(C(=O)C3=CC(C)=NN=C3O)C1 CCCS(=O)(=O)CC(=O)N1CCC[C@@H1]1[C@H1]2CCCN2C(=O)C3=NC=C(F)C=C3C CC1=CC=C(C(=O)N2CC[C@H1]([C@H1]3CCN(C(=O)CCCNS(C)(=O)=O)C3)C2)C=C1 CC1=C(C(=O)N[C@@H1]2COCC[C@@H1]2NC(=O)[C@](C)(O)CC3=CC=CC=C3)C=CN1C COC(C)(C)CCN=C1N=C2SC=CC2=C(N[C@@H1](C)CN3CCCC3)[NH1]1 CC[C@@H1](C)OCC(=O)N1CCN2N=CC(CNC(=O)C(F)(F)[C@H1](O)CC)=C2C1 CC1=NN(C(C)C)C(C)=C1CC(=O)N[C@H1]2C[C@H1](NC(=O)C3CC4(CC[C@H1]4O)C3)C2 CCCCCCC(=O)N[C@H1]1[C@H1]2C[C@@H1]3[C@H1]1[C@@H1]3[C@@H1]2C(=O)N[C@@H1]4CCC[C@@H1](CC)C4 CCS(=O)(=O)NCCNC1=CC=C(Br)C(S(=O)(=O)NCC=CC2CC2)=N1 CN(C[C@H1](O)CN(C)C(=O)[C@@H1]1C[C@H1]1C2CCOCC2)C(=O)C3=CSC=N3 CN(C)[C@H1]1C[C@H1](C(=O)N2CCN(C(=O)[C@H1]3CC3(C)C)[C@@H1](CC4CC4)C2)C1 CC(=O)NCCNC(=O)[C@@H1]1CCC[C@]12CCN(C(=O)CCC3CCCC3)C2 C#CCCCONC(=O)C1(CNC(=O)C2=CN=NC=C2C)CCC1 CC[C@H1](CCC(=O)N1CC[C@@]2(COC(=O)N2)C1)NC(=O)C(C)(C)[C@@H1](C)O C[C@]1(C(=O)NCC2CCN(C(=O)C3=CN=C(C=4C=COC=4)S3)CC2)C[C@@]1(F)Cl CCCCC(=O)C(=O)N[C@H1]1CCN(C(=O)C2=CC(C)=C(C)S2)[C@H1](C)C1 CC[C@@H1](NC(N)=O)C(=O)N1CC[C@H1](NC(=O)C2CCC(C)CC2)[C@H1](C(N)=O)C1 O=C(C1=C(O)C=CC=C1O)N2C[C@H1]3[C@@H1](C2)N3C(=O)C4=CN=NC(Cl)=C4 CC1=CC(N)=CC(C(=O)NC[C@H1]2CC[C@H1](NC(=O)C3(C4=CC=CS4)CC3)C2)=C1 CCN(CCCNC(=O)CNC=O)C(=O)C=C1CCC1 COC1=CC=CC=2C(C(=O)N[C@@H1]3CN(C(=O)CC4(CSC)CC4)CC35CC5)=CSC1=2 CCC1(C)CC(C(=O)N2CC[C@H1](C)[C@@H1]2CNC(=O)C=3C=NN(C)C=3C(F)(F)F)C1 CCN1N=CC=C1C(=O)N[C@@H1](CNC(=O)C(C)(C)OC)C(C)(C)C CCOC[C@H1](C)C(=O)N1C[C@H1](NC(=O)C=C2CCC2)[C@H1]3CCC[C@@H1]31 C=CCN1C=C(C(=O)N2C[C@H1](NC(=O)C[C@@H1](OC)C(F)(F)F)CC2(C)C)N=N1 O=C(C=CI)NCC[C@@H1]1CC(F)(F)CN1C(=O)CN2N=C(Cl)C=CC2=O CC1=NC(C)=C(C(=O)N2CCC[C@@H1](C(=O)NCCC3=CC=CS3)CC2)N=C1C CC(C)N1C[C@@H1](NC(=O)C2=CC3=COC(=O)C=C3[NH1]2)C[C@H1]1C CC=1N=C(N2CC[C@@H1](O)[C@H1](C(=O)NC3=NC=C(I)C=C3Br)C2)C4=C[NH1]N=C4N=1 CC1=C(Br)C=NC=C1[C@@H1](NCC2(CC3CCC3)CC2)C4=NN=NN4C(C)(C)C CCC(=O)NCC(=O)N1C[C@H1]2C[C@@H1](CN(C(=O)[C@H1]3CNC(=O)C3)C2)C1 CC=1C=NN(C(C)C)C=1C(=O)N(C)C[C@H1]2CCCN(C(=O)[C@H1]3C[C@H1]3C(N)=O)C2 CC[C@@H1](C)C=1C=C(C(=O)NC23COC(CNC(=O)C=4C=C(C)OC=4C)(C2)C3)ON=1 CC=1SC=C(C(=O)N2CC[C@H1]2C(=O)N3CCC4(CC3)CNC(=O)O4)C=1C C=C[C@@H1](CCC)CC(=O)NC[C@H1](C(=O)N[C@@H1](CO)CC1=CC=CO1)C(C)C CC1=CC(CC(=O)NCC2(O)CC(CNC(=O)C3=CC=C(Cl)C(F)=C3)C2)=NO1 COC(=O)[C@H1](OC)C(=O)N[C@H1]1CS(=O)(=O)C[C@@H1]1NC(=O)C2=NOC(C)(C)C2 C=CC1(C(=O)NCCCCCN(C)C(=O)COCCCC)CCCCC1 CC1=CC(CN2CCC(F)(CNC(=O)C3=CC=NC(Br)=C3Cl)CC2)=CC=N1 C[C@H1](CN(C)C(=O)[C@H1]1C[C@H1]1C)NC(=O)CCC2=NN=C(C(F)F)O2 O=C(NC[C@@]1(O)CCN(C(=O)CCC=2C=COC=2)C1)C=3SC=C(Cl)C=3Cl CN(C(=O)CC1=CC2=NO1)[C@@H1]CCN(C(=O)C3=CC(C(N)=O)=CC=C3F)C2 CCC[C@@H1](NC(=O)C=1C=NSC=1C)C(=O)N(C)C2=CC=CC(CC)=C2 CCSCCC(=O)NC1(C(=O)N2C[C@@H1](C)O[C@@H1](CO)C2)CC(F)C1 CC[C@]1(C(=O)N(C)CC(C)(C)CNC(=O)CN2C=CC=CC2=O)CC[C@@H1](O)CC1 C[C@H1](CNS(=O)(=O)C1=NC(N2CCC=3[NH1][NH1]C(=N)C=3C2)=CC=C1Br)N4C=CC=N4 CC1=NN=C(NC[C@H1]2CN(C(=O)OC(C)(C)C)C3(CCOCC3)C2)O1 CCC(CC)[C@H1](F)C(=O)N[C@](C)(CNC(=O)C1=CN(CC)C=N1)C(C)C CO[C@@H1]1CC[C@@H1](C(=O)N[C@H1]2C[C@H1](NC(=O)C3=CC=CC(C#N)=C3)C2)C1 CC1=CC=CC(CC(=O)N2CCC[C@@H1]2[C@H1]3CCCN(C(=O)CC4CC=CC4)C3)=C1 COC(=O)C1(CS(=O)(=O)N2C[C@@H1](CNC(=O)OC(C)(C)C)C[C@@H1]2C)CCOCC1 CCN1N=CN=C1C(=O)N[C@H1]2C[C@@H1]3C[C@H1](C2)CN(C(=O)C=4C=C5N(N=4)CCO5)C3 C[C@H1](CNC(=O)[C@H1]1CCNC(=O)C1)C(=O)N[C@@H1]2CCOC(C)(C)C2 CCCC[C@H1](O)C(=O)N1C[C@@H1](CNC(=O)C2(CF)CCOCC2)N3CC[C@H1]1C3 C[C@@]1(CC(=O)NC[C@@H1]2COC(=O)N2)CCN1C(=O)C=3C=N[NH1]C=3 C[C@H1](C(=O)NCCCNC(=O)C(C)(C)[C@@H1]1CCCN(C)C1)N(C)C CC1=CC=NC(CN(C(=O)NCC2=CC=C(C)C=C2OC3=CC=C(F)C=C3Cl)C4CC4)=C1 CC(C)(C1=CC=C(F)C=C1)C2(NC(=O)[C@@H1]3C[C@@H1](N)[C@@H1](N)CO3)CC2 CCC[C@@]1(NC(=O)[C@H1](C)P(C)(C)=O)CCCN(C(=O)CCC2=NC=C[NH1]2)C1 COC1=CC(C(=O)N(C)C[C@H1](C)C(=O)NC(C)(C)C(F)(F)F)=NN1C C=C=C[C@@H1](C)C(=O)NC1CC2(C1)C[C@@H1]2NC(=O)C3=CC(C)=C(O)C([N+1](=O)[O-1])=C3 C#C[C@@H1]1CCCN(C(=O)[C@H1]2COC3(C2)CN(C(=O)C4=NC(Cl)=CS4)C3)C1 C[C@@H1]1C[C@@H1](CNC(=O)C2(NC(=O)[C@@H1]3CC3(F)F)CCOCC2)CCO1 CCCC(=O)N1CCN(C(=O)C=CC2=CC=CC(C)=C2)[C@H1](C)[C@@H1]1C CC1=NOC=C1C(=O)NCCC2=CCN(C(=O)C=3C=C4N(N=3)CCC[C@H1]4O)CC2 CC1=CC=C(CO[C@@H1](C)C(=O)N[C@@H1](C)CNC(=O)C2=N[NH1]C(C)=C2C)C=C1 CC[C@H1](COC)C(=O)NC[C@]1(F)COCCN(C(=O)C2=CC(C)=C(C)C=C2N)C1 N#CC1=CC=C(C[C@@H1]2CCCCN2C(=O)NC[C@H1]3CC[C@@H1](F)C3)C=C1 C=CC1(C(=O)N2C[C@H1]3C=C[C@H1]2[C@@H1](C(=O)NCCN4C=C(C)N=C4CC)C3)CCC1 CCC(=CC(=O)NC[C@@H1]1CC[C@@H1](C)N(C(=O)C2=COC=N2)C1)CC CN(C[C@@H1]1COCCO1)C(=O)C[C@H1](NC(=O)[C@H1]2CCCCN2C)C(F)(F)F CC=C[C@H1](O)C(=O)N[C@H1](CNC(=O)CCCOC1=CC=C(Cl)C(C)=C1)C(C)C CC1=NN(C)C(C(=O)N2C[C@H1]C[C@@H1](NC(=O)C(F)(F)CC3CC3)C[C@H1]2C)=C1Cl C[C@](CO)(NC(=O)[C@H1]1C[C@@H1](CNC(=O)C2=CC=CC=C2)C1)C3CCC3 CC1=NOC2=NC=NC(N3CCC(C[C@H1](C)NC(=O)C4=CN=NN4C)CC3)=C12 COC1=CC=CC(C(=O)NC[C@H1](NC(=O)C2(C)CC(C)(C)C2)C(C)C)=C1O CN1C=C(Br)C=C1C(=O)N[C@@H1]2C[C@H1]2CNC(=O)CC3CCCCC3 COC[C@]1(C)C[C@@H1]1C(=O)N2CC(O)(CNC(=O)C3=CC(C)=CC4=C[NH1]N=C34)C2 O=C(C[C@@H1]1CCCCO1)NC[C@@H1]2CCCN(C(=O)C=C[C@H1]3CCCO3)CC2 CC1=CC=C(CCC(=O)N2CC[C@](CF)(C(=O)NCC3=NC=CN=C3C)C2)O1 CC1=CC(C(=O)N[C@H1]2C[C@]3(CCCCN3C(=O)[C@H1]4CNC(=O)N4)C2)=NC(C)=N1 C[C@H1]1CCC(C)(C)N1C(=O)[C@H1]2CCCC[C@H1]2CNC(=O)CN3C=C(C#N)C=N3 COCC1=NOC=C1C(=O)N[C@@H1]2CN(C(=O)CC3=CN=NS3)CCC2(C)C CC1([C@@H1]2CCCN(CC3=CC=C([N+1](=O)[O-1])C=C3)C2)CC1 NC1=CC(C(=O)N[C@H1](CNC(=O)CCF)C2=CC=C3C(=C2)OCO3)=C(F)C=C1F CC(C)=C(F)C(=O)N1CC[C@@H1]2CN(C(=O)C3=COC(C(N)=O)=C3)CC[C@@H1]2C1 COC1=CC(C2=NC=CN2CC[C@H1](C)N)=CC3=C1OCCO3 COC1=CC=CC(CC(=O)N[C@@H1]2C[C@H1]2NC(=O)[C@@H1](O)C3=CN=CN3C)=C1F CCC(CC)C(=O)NCCCN(CCO)C(=O)C1CC2(CCCC2)C1 CO[C@@H1](CC(C)(C)C)C(=O)N1CCN(C(=O)COCC2CC2)C[C@@H1]1C(C)C CC(C)(CNC(=O)CCC1=CC=CC=N1)CC(=O)NC2CC[C@H1]3C[C@@H1]3CC2 CCCCN(C)CCNC(=O)[C@H1](NC(=O)C[S@](=O)CCOC)C=1C=NN(C)C=1 CC[C@](C)(O)CC1=CN(CCCCCCNC(=O)C[C@H1]2C(=O)NN=C2C)N=N1 COC1=CC(OC)=NC(C(=O)N[C@@H1]2C[C@@H1]3C[C@H1](NC(=O)[C@H1]4CCNC4=O)[C@H1]2C3)=N1 O=C([C@H1]1CCN(C(=O)C2=CN(C3CC3)C=N2)CCN1C)N4CCC=5N=N[NH1]C=5C4 CC(C)[C@H1]1N(C(=O)CC=2N=C[NH1]N=2)CC13CCN(C(=O)CCC(F)(F)F)CC3 CC(C)[C@@H1]1CC[C@H1](C(=O)NC[C@H1]2CC(F)(F)CN2C(=O)C3CCCCC3)C(=O)N1 C[C@H1](C(=O)N(C)CC1=CC=CC=C1)N2CCO[C@]3(C[C@H1]4CC[C@H1](C4)C3)C2 COCC1(NC(=O)C2CC=CC2)CN(C(=O)[C@H1]3CCC4=NN=NN4CC3)C1 COCCC1CN(C2=NC(=NCC[C@H1](C)C3=CC=CC=C3)[NH1]C4=CC=CC=C24)C1 CC(=O)NCCN=C1[NH1]C(=NC[C@@]2(C)C[C@@H1]2Br)C3=CC(Cl)=CC=C3[NH1]1 CC=1C=CSC=1CC(=O)N2CC(N(C)C(=O)[C@H1]3CC4=CC(Cl)=CC=C4O3)C2 CN(CCC(C)(C)NC(=O)[C@H1]1C[C@H1]1Cl)C(=O)CCS(N)(=O)=O CC(C)(C)/C=C/CC(=O)N1CCC(O)(CCNC(=O)C2=CC=NN=C2O)CC1 CC1(NC(=O)CC=2C=C(C3CC3)ON=2)CCN(C(=O)[C@H1]4CCC(F)(F)CO4)CC1 CN(C)[C@H1]1CCCN(C(=O)CC2=CSC(=NCC3=CC(Cl)=CC(Cl)=C3O)[NH1]2)CC1 CCC1=CC=C(C(=O)N[C@H1]2C[C@@H1]3C[C@H1]2C[C@@H1]3C(=O)N4CC(C)(C)C4)C=N1 CC(C)=CCCC(=O)NC[C@H1]1C=2C=CSC=2CCN1C(=O)[C@@H1](C)O C[C@H1](CN=C1C=CC2=NC=C[NH1]C2=N1)CN3CCN(C)CC3 CC(C)(C)[C@@H1](CO)C(=O)N1CCC(C2CCN(C(=O)[C@@H1](F)C(C)(C)O)CC2)CC1 COC(C)(C)C(=O)NC[C@](C)(CC(C)C)NC(=O)C1CCN(C2=NC=CS2)CC1 C#CCN(C(=O)[C@@]12CC[C@@H1](N3C=C(CCCCO)N=N3)[C@@H1]1C2)C(C)C O=C(C=C1CCCCC1)NCC[C@H1](O)CNC(=O)CN2C=CC=NC2=O CC=1C=C(C(=O)N[C@H1]2CCN(C(=O)/C=C/CN(C)C)C[C@H1]2CO)OC=1Br C[C@H1](C(=O)N1CC(C)(C)C[C@@H1]1CNC(=O)C2(C)CCC(C)(C)CC2)N3C=CN=C3 CCC[C@H1](CNC(=O)C1=CC2=CC=CN2C=N1)C(=O)N(CC)CC(=O)NC CC1(C)C[C@H1](CNC(=O)[C@@H1]2CC[C@H1](F)C2)N(C3=CC=NC=C3C#N)C1 CSC1=CC=C(C(=O)N[C@H1]2C[C@@H1]2C(=O)NC3=CC=C(CO)C=C3C#N)S1 CCC1=NC(=N)[NH1]C(=N[C@H1]2C[C@](F)(CNC(=O)[C@@H1]3OCC3(C)C)C2)[NH1]1 NC(=O)[C@@]12CCC[C@@]1(C(=O)NC3(CNC(=O)C4=CN=C(C=5C=CSC=5)S4)CC3)C2 COC1CC(CCC(=O)NC2([C@@H1]3CCN(C(=O)[C@H1]4C[C@@H1](F)C4)C3)CC2)C1 CN1C(=O)CN(C(=O)C2=CN(CCC3CC3)N=N2)C4=CC=C(Br)C=C41 CC1=CC=C([C@@H1](C)NC(=O)[C@@H1]2C=CCN2C(=O)C=3[NH1]C=CC=3C)N=C1 COC1=CN=NC(C(=O)NC2([C@H1]3CCCN3C(=O)C[C@@H1](C)C4CC4)CC2=C)=C1 C=C1CC(C(=O)N2[C@H1](CNC(=O)C3=N[NH1]C4=NC=CC(Cl)=C34)[C@H1]5CC[C@@H1]2C5)C1 C#CCCC1=CSC(NC(=O)N[C@@H1](C2=CC=C(CC)C=C2)C(C)C)=N1 C[C@@H1]1C[C@@]1(C)C(=O)NCC2=NOC=C2C3=CC=CC=C3 CNS(=O)(=O)C1=CC=C(C(=O)N2CCC[C@@H1](NC(=O)C3=CC=CC=C3O)C2)O1 CCOC(=O)C1=C(CCl)N([C@H1](C)CC)C(=O)N[C@@H1]1C=2C=NN([C@H1](C)CC)C=2 C[C@@H1](C(=O)NC1(CNC(=O)C2=NC(=N)C=C[NH1]2)CCCC1)C3=CC=CC(Cl)=C3 O=C(NC1CC2(C1)CN(C(=O)CON=C3CCCCCC3)C2)[C@@H1]4CCCC[C@H1]4O N#CC1=CSC=C1C(=O)N2C[C@@H1](NC(=O)CNC(=O)C3CCC3)C4(CCCC4)C2 CC(=O)NCCC(=O)N1C[C@@]2(NC(=O)C=3C=NN(CCF)C=3)CCC[C@@]2(F)C1 CCOC1=CC(NC2CC(NC(=O)C3=CC=NC(SC)=C3)C2)=CC=C1[N+1](=O)[O-1] CN(C(=O)C1CC(N(C)C(=O)C2[C@H1]3CCC[C@H1]23)C1)C4CCCCCC4 C=CN1N=NC=C1C(=O)N2CC[C@@H1](C)[C@@H1]2CNC(=O)C=3OC=NC=3CC CC1=NC=CN1CCC(=O)N(C)C[C@@H1](C)C(=O)N[C@H1]2CCC[C@@H1]2F CC[S@@](=O)C1=CC=CC=C1C(=O)N(C)CCCN(C)C(=O)C(C)(C)CC(C)C CCOC1=NC(Br)=CN=C1NS(=O)(=O)C2=CC=CC(C(=O)NC[C@H1](C)OC)=C2 CCC1=CN2C(C(=O)N(C)CCCN(C)C(=O)OC(C)(C)C)=CC=CC2=N1 CC(=O)C1=CC=C(C(=O)N[C@@H1](C(C)C)[C@@H1](C)NC(=O)C2(Br)CC2)C(F)=C1 C=CC[C@H1](CCCCC)C(=O)NC[C@@H1]1C[C@@H1]2C[C@@H1]2N1C(=O)C[C@@H1]3CCSC3 C[C@@H1]1CCC[C@H1](CC(=O)N[C@@H1](CNC(=O)C[C@@H1]2CCC[C@H1]2O)CC(F)(F)F)O1 C[C@H1](CNC(=O)CSC1=CC=CC(F)=C1)CNC(=O)C2=CC=C(CCO)C=C2 CC(C)CC1=CC=C(CC(=O)N2CCSC[C@H1]2C(=O)N3CCC[C@@H1](CCO)C3)C=C1 CC1(C)CN(C(=O)C=2C=C(CO)ON=2)C[C@@H1]1C(=O)N[C@@H1]3COC[C@H1]3O O=C(NC[C@@H1](O)C(=O)N1CCC(=C(F)F)CC1)C2=CC=[N+1]([O-1])C=C2 C=C[C@@H1](CCC)CC(=O)N1CC[C@](COC)(NC(=O)CCOCC2CCC2)C1 CCC(=O)N1CCC[C@H1](C(=O)NC2CN(C(=O)C3=C(CC)N=C(C)N=C3C)C2)C1 C=C1CC(C(=O)N2CCOC[C@@](F)(CNC(=O)C[C@H1]3CCCN3C)C2)C1 CC[C@H1](NC(=O)[C@H1](CC1=CC=CO1)NC(=O)C2=NC=CN2C)C(=O)OC C[C@H1](CCC(=O)N(C)[C@H1]1CN(C(=O)C2=CC=C[N+1]([O-1])=C2)CC[C@H1]1O)S(C)(=O)=O CC1=NC=CN=C1[C@H1](C)NC(=O)N2CCC23CCN(CC4=CC=CC=C4)CC3 CCS(=O)(=O)C1=CC=CC(C2=NOC([C@@H1](N)CC3=CC=CC(I)=C3)=N2)=C1 CC[C@@H1]1[C@H1](C(=O)N2CC3(C2)CC(C)(O)C3)CCN1C(=O)COCCN(C)C C[C@@H1](NC(=O)C[C@@H1](F)Cl)C1(O)CN(C(=O)[C@H1]2CC(=O)OC2(C)C)C1 C[C@@H1](CNC(=O)CCN(C)CCC(C)(C)C)N(C)C(=O)C=1C=C(C2CC2)[NH1]N=1 CN=C1C=C(C2=CC=C3C(C(=O)N4COCC4(C)C)=NOC3=C2)C=C[NH1]1 CCN(CC=1C=COC=1)C(=O)C23CC(CN2C(=O)C[C@@H1]4C=CCC4)C3 CCC[C@@H1]1C[C@H1]1C(=O)N[C@H1](C)CN(C)C(=O)CN=C2C=C[NH1]C=C2 O=C(N[C@H1](CCF)C(=O)N1CC(F)C1)C2=CC=CO2 COC1=CSC=C1C(=O)N[C@@H1]2CN(C(=O)C3=C(Cl)C=CC(F)=C3C)C[C@H1]2C(F)F CC=1C=C(CC(=O)N[C@H1](C)C[C@H1](C)NC(=O)[C@H1](CC(C)C)NC(N)=O)N(C)N=1 CC1=CC(C(=O)N2C[C@H1]3[C@H1](CC(=O)NC[C@@]45CC=C[C@@H1](C4)OC5)[C@H1]3C2)=NN1C CN1C=NN=C1C2CN(C(=O)[C@]3(C)CCN(C(=O)[C@H1]4C(C)(C)C4(F)F)C3)C2 CCC(=CC(=O)N[C@H1](C)CCN(C)C(=O)C1=CC=C(CN2CCCCC2=O)S1C)C CC[C@@H1](C)CC(=O)C(=O)N[C@H1](C(=O)NC1CC(C)(C)C1)C2=CC=CS2 CC=1OC=CC=1C(=O)N2C[C@H1](O)[C@@H1](N(C)C(=O)C3=NOC4=C3CCCC4)C2 COC/C(C)=C/C(=O)N[C@@H1]1C[C@@H1](C)N(C(=O)CC2=CC=C(C(F)(F)F)C=C2C)C1 CC(C)=C(C)C(=O)N[C@H1]1CC[C@H1](NC(=O)C[C@H1](C)CCC)C1 OC1=CC=C(CNCCCCC=2C=NN(C3=CC=CC=C3)N=2)C(Cl)=C1 CSC1=NC=CC=C1C(=O)N2CC(C(=O)NC3=CSC4=NC=CN=C34)C2 CCN(C(=O)COC1CCCCCC1)[C@H1]2CCN(C(=O)C3=CC4=C[NH1]N=C4S3)C2 CC=1N=C(C2CCC2)OC=1C(=O)NC3(C(=O)O)CC(CO)C3 O=C(N[C@@H1]1CCN(C(=O)CCC2=CC=CS2)C1)C3=CN=C(C4CC4)N=C3O C[C@@H1](CN(C)C)C(=O)NCCC1(NC(=O)[C@H1]2SCCC=3SC=CC=32)CCC1 O=C(CCOC1CCCC1)N[C@H1]2[C@@H1]3CN(C(=O)CSC4=NN=NN4C5CC5)C[C@@H1]32 CCOCC1=NC(C(=O)N2CC[C@H1](NC(=O)C3=CC(C#N)=NO3)[C@@H1]2C)=CS1 C[C@H1]1CCCN(C(=O)C2=CN=N[NH1]2)[C@@H1]1CCNC(=O)CC(F)(F)Cl CC1=NN(C)C=C1[C@H1](O)C(=O)N[C@H1](C)CN(C)C(=O)[C@@H1](C)CSC(F)(F)F C=CCCC(=O)N1CCN(C(=O)[C@@H1]2CC2(COC)COC)C[C@@H1]1C3CCCC3 O=C(CCC=1C=NOC=1)N2CCC[C@@H1]([C@@H1]3CCCN3C(=O)C#CC4CC4)C2 CC1=COC(C(=O)NC=2SC=CC=2C(=O)N[C@H1]3C[C@]3(C)C4=CC=CC=C4)=C1 CC1=CC=C([C@@H1](O)C(=O)NCCNC(=O)CSCCC#N)N=C1 C[C@@H1](O)C(F)(F)C(=O)NCC=1N=COC=1CCNC(=O)[C@@H1]2CC3(CC3)CO2 CSCCCCCCCC(=O)NC[C@H1]1[C@H1](O)[C@H1](O)CN1C(=O)[C@H1](C)OC C[C@@H1]1C[C@H1](NC(=O)CCN2N=CN(C)C2=O)CN1C(=O)C3=CC(F)=CN=C3O CO[C@H1](C(=O)N1CC2(CCOCC2)C[C@@H1]1CNC(=O)CCN3C=CC=N3)C(C)C CC1=NO[C@H1](C(=O)N[C@@H1](CCF)C(=O)N[C@@H1]2CCC3=CC=CC=C32)C1 C[C@@H1](NC(=O)C12CC(C)(C1)C2)[C@@]3(O)CCN(C(=O)CCN4C=NC=CC4=O)C3 O=C1C(Cl)=C(NCC2CCC3(CCCCC3)CC2)C=NN1 COC1=CC=C(N[C@@H1](C[C@H1]2CCCCO2)C3=NN=NN3CC(F)F)C=C1[N+1](=O)[O-1] CC1=CC[C@H1](C(=O)NCC2(F)CN(C(=O)C3=CN4C=NN=C4C=N3)C2)CC1 CC1=C(C(=O)N2CC[C@H1](CNC(=O)C3=C(Cl)C=CC(C)=C3N)[C@H1](C)C2)CCCO1 CCCCCC[C@H1](CC)C(=O)NC[C@@H1]1CCCCN1C(=O)[C@H1]2C[C@@H1](OC)C2 CSC1=CC(C(=O)N2CC[C@](O)([C@H1](C)NC(=O)C=C(C3CC3)C4CC4)C2)=NN1C O=C(COCC(F)F)NC12CCC(CC1)N(C(=O)[C@@H1]3COCC4=CC=CC=C43)C2 CN1C=NC=C1CCC(=O)N2CCSC[C@H1]2C(=O)NCCN=C3C=C[NH1]C=C3 CCCC1=CN=NC(C(=O)N2CCO[C@@]3(CCN(C(=O)C=C(Cl)Cl)C3)C2)=C1 CC1=CC(C)=CC(C(=O)N2CCN(C(=O)CC3=CC(Br)=CC=C3Cl)[C@@H1]4C[C@@H1]42)=C1 CC[C@H1](CNC(=O)C1=NC=CN1C)NC(=O)[C@@H1]2CCCC[C@H1]2C CCCC[C@H1](C(=O)N[C@H1]1C[C@@H1]2C[C@H1]1N(C(=O)C(=O)NCC(F)F)C2)C(C)C CCOC(=O)CC(=O)N1CCC[C@H1]2CN(C(=O)C3=CN=C(O)O3)CC[C@@H1]21 CC(C)(CNC(=O)C(C)(C)CCNC(=O)C=CC1=CC=C[NH1]1)C2CC2 CC[C@@H1](C)CC(=O)N[C@@]1(CO)CCN(C(=O)CC2=CCOCC2)C1 CCN1N=C(C(=O)N2C[C@H1](F)[C@@H1](N(C)C(=O)C3=CC=CN4C=NN=C34)C2)C=C1O C=CCC(C)(C)C(=O)NC[C@H1]1CC[C@@H1](NC(=O)CC2=CN(C)N=N2)C1 CC(C)CC[C@H1](O)C(=O)N(CC(=O)N(C)CCCF)C1CC1 CC(C)(C)OC(=O)N1CCC[C@H1]2CN(C3=NC=CN4C=C(CC(=O)O)N=C34)C[C@H1]21 CNC(=O)C1=CC(S(=O)(=O)NC(=O)C2=NC(COC)=NO2)=CN1C O=C(C1=COCCC1)N2CC(OCCNC(=O)C3(C(=O)NC4CC4)CC3)C2 COC[C@@]1(NC(=O)C[C@@H1](O)C2CCCC2)CCN(C(=O)C=3C(C)=NN(C)C=3N)C1 NC1=CC=CC(F)=C1C(=O)N2CCN(C(=O)[C@H1](O)C3=CC=CO3)C[C@H1](O)C2 CC(C)(CNC(=O)C=1C=CN(C(F)F)N=1)CNC(=O)C2=CC(F)=CC=C2O CC=1C=C(CO)OC=1C(=O)NC[C@@H1]2CC[C@H1]2NC(=O)[C@H1]3C(F)(F)C34CC4 C[C@@H1](CCNC(=O)COCC(=O)OC(C)(C)C)NC(=O)[C@@H1]1OCCC1(C)C N#CCC(=O)N1C[C@H1]2CC[C@@](NC(=O)C3=CC=C(C4=CC=CC=C4)C=N3)(C2)C1 CCS(=O)(=O)NC1=CC=CC(C(=O)N[C@H1](C)CNC(=O)/C=C/C=2N=C[NH1]N=2)=C1 CC1(C)CN(C(=O)CCC2=CSC=N2)CC[C@@H1]1NC(=O)[C@H1](F)N3C=CC=N3 CNC(=O)COCC(=O)N(C)C[C@H1]1[C@@H1]2CN(C(=O)CN3C(=O)CNC3=O)C[C@H1]12 CCOCCNC(=O)C1=CON=C1CNC(=O)C2=CC=C(C)C(C)=C2 C=C(C)COCC(=O)NC[C@]1(O)CCCN(C(=O)[C@H1](CC(F)F)C2CCC2)C1 O=C(NC12CC(C(=O)NCC3CCCCCC3)(C1)C2)C4=CC=CN5C=CN=C45 NC1=CC(F)=CC=C1C(=O)N2C[C@H1]3CCN(C(=O)C[C@@H1]4CCC45CCC5)[C@H1]3C2 CCCCNC(=O)[C@H1](C1=CC(OC)=CC(OC)=C1)N(C)CCCC=2SC=NC=2C C[C@@H1]1CCO[C@@H1]1C(=O)N(C)C2CN(C(=O)C3=C(C4CCC4)C=NN3C)C2 CC=1OC(C(=O)N2C[C@@H1](NC(=O)C[C@H1]3CCC[C@H1](C)C3)CC4(CC4)C2)=CC=1CO CNC(=O)N[C@@H1](C)C(=O)N1CCN(C(=O)CNC(=O)C2=NC=CC=N2)C[C@H1]1C CC=1C=C(C(=O)N2CC[C@@H1](O)[C@H1]2C(=O)NC3=CN=NC(Cl)=C3Cl)ON=1 FC1=CC=CC(OCCN=C2[NH1]C(=NCCC3=CC=CC=C3)[NH1]C=4C=CSC2=4)=C1 C=C(C)CC(=O)N[C@@H1](C(C)C)[C@@H1](NC(=O)C1=CC=CN1CCC)C2CCCCC2 CCN1C=CC(C(=O)NCCC2CN(C(=O)C3=CN=C(C(C)C)S3)C2)=C1C CCOC1=CN=CC(C(=O)N[C@H1](C)CNC(=O)CC2CN(C)C2)=C1 CN(C)[C@@H1](C(=O)NC[C@H1]1C[C@H1](CNC(=O)C=CC=C(Cl)Cl)C1)C2CC2 CC(C)[C@]1(C(=O)N[C@@H1](C)CCC=2C=N[NH1]C=2)CCCN1C(=O)CCF COCC[C@H1]1CCCN(C(=O)[C@H1](C)C2CCN(C(=O)C(C)(C)CCSC)CC2)C1 C[C@@]1(CCNC(=O)[C@H1]2CCC3=CC=CC=C32)CCN(C(=O)CCN4C=CN=C4)C1 CC(C)(C)OC(=O)N1C[C@@]2(CNC(=NCC3CC3)NC[C@H1]4CCCCO4)CC[C@H1]1C2 CC[C@@H1](C(=O)NC/C=C/CNC(=O)CCOCC1CC1)N2CCN(CC)CC2 CN1N=C(C(=O)NCC2=CC(C3CC3)=CC=C2)C4=C1CCOC4 C[C@]1(C(=O)O)CCN(C(=O)C2=CC=CN=C2C3=CN=CC=N3)C1 CCC1=CC=CC(OCC(=O)N2C[C@H1]3[C@H1](NC(=O)C4=CC=CC(C#N)=C4)[C@H1]3C2)=C1 CN1C=C(N)C(C(=O)N2C[C@H1]3[C@H1](NC(=O)[C@H1]4CC5=CC=C(F)C=C5O4)[C@H1]3C2)=N1 CC1=NC2=CC(C(=O)NCC3CN(C(=O)C4=CC=NC5=NC=NN45)C3)=CC=C2O1 CN(C[C@H1](O)CN(C)C(=O)C1(O)CCCC1)C(=O)C(=O)C(F)(F)F COC1=CC=C(CCC(=O)N[C@@H1]2CN(C(=O)C3=CC=C(C(N)=O)O3)C[C@@H1]2C)C=N1 C[C@H1](NC(=O)C[C@H1]1C[C@@H1](C)N(C(=O)CNC2=CC=CN=C2)C1)C3=CN=CS3 C=C[C@@H1](C)CC(=O)NCCN1CCN(C(=O)C2CN(S(=O)(=O)CC)C2)CC1 CC(C)=C(Br)C(=O)N[C@@]12CCC[C@H1]1N(C(=O)C3=NNC(=O)CC3)CC2 C=CCN1N=NN=C1[C@H1](N[C@@H1](C=2C=CON=2)C3=NN=NN3C4CC4)C(C)(C)CCl CC(=O)NCCC(=O)NC[C@H1]1C[C@H1](NC(=O)C=2N=NN(C(C)(C)C)N=2)C[C@H1]1O C=C(C)COCC(=O)N1CC[C@@H1](CCNC(=O)[C@H1](C)CC(=O)C2=CC=C(Cl)C=C2)C1 CN1C=NC=C1C(=O)NCCC2(O)CN(C(=O)C3=CC(O)=NC(C4CC4)=N3)C2 C[C@@H1](NC(=O)[C@@H1]1C[C@H1](O)CCN1C(=O)C2=NC=CS2)C3=CC=CN=C3 CC1=NC(=N)[NH1]C(C)=C1C(=O)N(C)CC[C@H1](C)NC(=O)C2=NC=CN=C2C(N)=O CC1=C[NH1]N=C1C(=O)N[C@@H1]2CCSC23CN(C(=O)CC4=CC=CS4)C3 CCS[C@H1](C)C(=O)N1CC[C@](C)(NC(=O)[C@H1]2CCC3=NC=NC(C)=C3C2)C1 CCOC1=CC=C(CCN(C)C(=O)N[C@H1]2CC[C@@H1]([C@H1](F)C(=O)OCC)C2)C=C1 CCN(CC(=O)N1CC[C@@H1](C)[C@@H1]1C(=O)N2C[C@H1](O)[C@H1](O)C2)C3CC3 CCN(CC)CC(=O)N1CC[C@H1](C(=O)NCCCCCC(=O)NC)C1 COC[C@@H1](C)CC(=O)NC[C@H1]1N(C(=O)CCC2=CC=C(Cl)C=C2Cl)CCC1(C)C CCC1=CC=C(C(=O)N(CCNC(=O)C23CC(F)(C2)C3)CCOC)C=C1C#N CSC1(CNC(=O)C2(C)CC(NC(=O)C3=C[NH1]N=C3C)C2)CCC1 CC(C)(C(=O)N[C@H1]1C[C@H1]2C[C@@H1](NC(=O)CCN3CCOCC3=O)[C@@H1]12)N4CCCC4 CN1N=C(C(=O)NCC2=CSC(CNC(=O)C3=CSCS3)=N2)C=C1Cl CCCC[C@@H1](N=C1NS(=O)(=O)C2=CC=CC=C21)[C@@](C)(O)C3=CC=CC=C3 CCS[C@H1](C)C(=O)N[C@H1]1CCCC[C@H1]1NC(=O)C=2C=NN(C)C=2C3CC3 CC1=C(C)C[C@@H1](C(=O)N2CC([C@@H1](C)NC(=O)[C@H1](C(C)C)N(C)C)C2)CC1 CNC(=O)[C@@H1](C)NC(=O)[C@@H1]1CCN(C(=O)CN2CC(C)(OC)C2)C(C)(C)C1 CC(C)[C@H1](O)[C@H1](C)C(=O)N1C[C@@H1](CC(=O)NCC(C)(C)C)C[C@H1]1C CC(C)(CNC(=O)C1=CC=CC=C1)[C@@H1]2CCCCN2C(=O)CCC3=NN=CS3 C[C@@H1](CO)C(=O)N(C)[C@H1]1[C@@H1]2CN(C(=O)C3(CCO)CC3)C[C@@H1]21 COC1=CC=C(C2(CNC(=O)COCCF)CN(C(=O)C[C@@H1](C)CF)C2)C=C1 C[C@@H1](CC(=O)N(C)C[C@@]1(O)CCCN(C(=O)CO[C@@H1]2CCC[C@@H1](C)C2)C1)C3CC3 CCOC(=O)C=1C=NN(C2CCN(C(=O)[C@]3(O)CCNC3)CC2)C=1 COCO[C@@H1](C)C(=O)N1CCN(C(=O)CN(C)C(=O)CCCCCCSC)CC1 C#CC1=CC=C(C[C@@H1](NC(=O)C2=CC=C(S(C)(=O)=O)C=C2Br)C(=O)OC)C=C1 O=C([C@@H1]1CCC2(CN(C(=O)[C@H1]3C[C@H1]3C(F)F)C2)O1)N4CCC[C@H1]5CCC[C@@H1]54 CCC(=CC(=O)NC[C@]1(C)CCCN1C(=O)C2C[C@H1]3C[C@@H1]3C2)C4=CC=CC(Cl)=C4 CN1N=NN=C1[C@H1](NC2=CN=C3N2CCOC3)C4=CC=C5C(=C4)N=CN5C CCCC1=CC(C(=O)NC2[C@H1]3C[C@H1]2CN(C(=O)[C@@H1]4[C@H1]5CCC[C@H1]54)C3)=NN1C C[C@@H1]1CC[C@H1](NC(=O)C=2SC=C(Cl)C=2Cl)CN1C(=O)C3=CC(O)=NC(O)=N3 CCOC(=O)CCN(C)C(=O)[C@H1](CC)NC(=O)C(C)=CC1CC1 C#CCCC1CN(C(=O)[C@@H1](CCOCC)NC(=O)C2=CC=CN2C3CC3)C1 CO[C@H1]1COCC[C@@H1]1CN2N=NN=C2N(C)CC3=CC(N(C)C)=CC=N3 CCNC1=CN=CC(C(=O)N2CC[C@@H1](C3CC3)[C@H1]2CNC(=O)C(C)=C(C)C)=C1 CCC1=CC=C(F)C(C(=O)NC[C@@H1]2CN(C(=O)[C@@H1]3C[C@H1]3C(C)(C)O)C[C@H1]2O)=C1 CC(OCC(=O)N1CC2(CCC[C@@H1]2NC(=O)[C@@H1]3CN4CC5CC4(CO3)C5)C1)CCC COC1(CCN2CCN(CC(C)(C)O)[C@@H1](C)C2)CNC1 C[C@H1](C(=O)NCCOCCNC(=O)CO[C@@H1]1CCOC1)N2CCOC2=O CC1=CC=CC(CCN=C[NH1]C(=N[C@H1]2CC[C@H1](CO)C2)C3=C(N=CN3C)[NH1])=N1 CCC1=CC=C(C(=O)NCC[C@@H1](C)NC(=O)CC2(C)CCC2)C=C1C#N CC1=CC(C=2N=C(C3=NC=NC=4OC=CC3=4)N(C5=CN=CC(C)=C5)N=2)=NO1 CN1CC[C@@H1](CC(=O)N(C)CCCCNC(=O)[C@H1]2CCC3=CC=NN3C2)C1 C[C@@H1]1CCN(C(=O)[C@@H1]2CCC3=N[NH1]C=C3C2)CCN1C(=O)[C@H1]4CC[C@H1]5C[C@H1]5CC4 O=C(NCCOCCCNC(=O)C1(C(F)F)CCCCC1)C2=CC=CN=C2O CC1(C)CC(NC(=O)[C@@H1]2CCCC=3N=C(C4=CC=C5N=CC=CC5=C4)SC=32)C1 COC1=CC=C(N)C(C(=O)N2CCC[C@]23CCN(C(=O)C4=CN=C(Cl)S4)C3)=C1 O=C(C1=CC=NC(C2=CC=C(Cl)C=N2)=C1)N3CCC4=CC=CC=C4[C@H1](O)C3 CC=C1C(C#N)=NC(=NC[C@@]2(O)CCCN(C(=O)CCCCN3CCCCC3)C2)[NH1]1 COC[C@](C)(O)CC(=O)N1CC[C@@]2(C=C(C(=O)N[C@H1](CO)CN(C)C)C2)C1 O=C(C=C1CCC1)N[C@@H1]2C[C@@H1]2NC(=O)C3=CC(N4C=CC=N4)=CC=N3 CC1(C)CO[C@H1]1C(=O)NC[C@H1](NC(=O)C=CC2=CC=CC([N+1](=O)[O-1])=C2)C3CC3 CO[C@@H1](CCSC)CN=C1C=C[NH1]C=C1S(=O)(=O)NCC2=CN=CN=C2 CN(CCOC1=CC=CC(F)=C1)CC=CC(=O)C23CC4CC(CC(C4)C2)C3 CC(C)(C)OC(=O)NCC[C@H1]1CCCN(CC2=NN=NN2C3CCC3)C1 C[C@@H1](CN1N=CC2=CC=CC=C21)C(=O)NC[C@H1](CO)CNC(=O)CC(C)(C)C COCCN(CC(C)C)C(=O)CN[C@H1](C)C1=CC=C(O)C(F)=C1 C[C@@]1(C(=O)N2CCC(NC(=O)C3=CSC(C(F)F)=N3)CC2)CCOC1 O=C(C[C@@H1]1C=CS(=O)(=O)C1)NC[C@@H1](O)CNC(=O)C2=CC=NN2C3CCOCC3 CC1=CC=C(CC(=O)NCCCNC(=O)[C@H1](CCF)NC(=O)OC(C)(C)C)S1 CC1=NC=C(C(=O)N2C[C@@](C)(C(=O)N[C@@H1](C)C3=NN=C(C)S3)CC2(C)C)S1 C#CC1=CC=C(F)C=C1C(=O)N[C@@H1](CO)CNC(=O)[C@@H1](OC)C(C)(C)C COC1(C#N)CC(C(=O)N2CCC[C@@H1](C(=O)NCC=3N=COC=3COC)CC2)C1 O=C(N[C@@H1]1CCN(C(=O)[C@@H1](O)C2=CC=C3C=CC=CC3=C2)[C@H1]1C4CC4)[C@H1](O)CF CCC1=CC=C(C(=O)N2CC[C@@H1]3[C@H1](CCN3C4=NC=CC(OC)=N4)C2)C=N1 C[C@H1](CC(=O)N[C@](C)(CO)CNC(=O)C1=N[NH1]C=C1C2=CC=CC=C2)C3CC3 CCCN1N=C(C(=O)NCCCS(=O)(=O)CCOCC)C=C1C2CC2 CC(C)(CS(N)(=O)=O)C(=O)NCC1(O)CN(C(=O)C(C)(C)CC2=CC=CC=C2)C1 C#CCCCOCC(=O)N[C@@H1](CCC=C)C(=O)N(C)C[C@@H1](F)Cl CC1=COC(C=CC(=O)N2CCC[C@H1]2CNC(=O)C=C(Cl)Cl)=N1 CCCCCC(=O)NC[C@H1](CNC(=O)[C@@H1]1CC=CC[C@H1]1C)OC CSC(=O)CNC(=O)[C@@H1](N1C=C(C2=CC3=CC=CC=C3S2)N=N1)C(C)(C)C CN(CC(=O)N1CC[C@](CF)(NC(=O)C2=CCCOCC2)C1)S(C)(=O)=O CC1=NN(C(C)C)C=C1C(=O)N2CC[C@H1]2CNC(=O)CC3CS(=O)(=O)C3 COC[C@H1]1CCN1C(=O)C2C[C@@H1]3CC[C@H1](C2)N3C(=O)C=4[NH1]C=CC=4COC C=CCC(CC=C)C(=O)NCCCCCCC(=O)N1CCC[C@@H1]1CCC CCCC[C@@](C)(F)C(=O)NCCOC1CCN(C(=O)C2CC3(C2)C[C@H1]3F)CC1 CC=1C=C(C(=O)N2C[C@@H1]3C[C@H1](C2)[C@H1](NC(=O)[C@H1]4COC(=O)O4)C3)C5=NC=CN5C=1 COC1=CC(C(=O)N[C@@H1]2CCCC[C@@H1]2NC(=O)CCCNC(N)=O)=NN1C C[C@]1(CNC(=O)C[C@H1](CC2CC2)NC(=O)[C@@H1](O)CC3CCCC3)CCOC1 C[S@@](=O)(=NC(=O)C=1C=C(C2=CC=C3C(=C2)OCCO3)ON=1)C4CCNCC4 CC=1C=CSC=1C2=CN(CC(=O)N[C@@H1](C)CC(C)(C)O)N=N2 COC1=CC(C(=O)NCC(C)(C)OCCNC(=O)[C@@H1](C)N(C)C)=CC=C1O CCC1=NN(C)C(CC(=O)N2CCC[C@H1](CNC(=O)COC(C)C)C2)=C1Cl CC(=O)N[C@H1](C)C(=O)N1C[C@H1]2[C@H1](CNC(=O)[C@@H1]3COC[C@H1]3C(N)=O)[C@H1]2C1 CCCC[C@H1](CNC(=O)[C@H1]1C[C@@H1]1C)NC(=O)[C@H1](O)CC=2C=NN(C)C=2 C/C=C/C[C@H1](C)C(=O)N[C@H1]1COCC[C@H1]1NC(=O)CCC2=CC=NC=N2 C#CCC1(C(=O)N2CC[C@@H1]3CN(C(=O)CC(C)(C)CC)CC[C@@H1]3C2)CCCCC1 CN1CCC(OCC(=O)N[C@H1](CNC(=O)[C@H1]2CCC3(CCC3)C2)C4CC4)CC1 COC1=CC(CNC2=CC=C(OCC#N)C=C2)=C(Cl)C=C1OC C[C@@H1](O)CN(CCNC(=O)CC1=CN=C[NH1]1)C(=O)COC2=CC=CC(Cl)=C2Cl COC1=NC=CC=C1C(=O)N2CCC[C@H1]2CCNC(=O)[C@@H1]3CC[C@H1](C(F)(F)F)O3 C[C@@H1]1CN(C(=O)COC2CN(C(=O)C3=N[NH1]C(O)=N3)C2)CC[C@@H1]1N(C)C C[C@H1](CNC(=O)CC1=CC=NN1C)NC(=O)C2=NC(C3=CC=C(Cl)C=C3)=NC=C2 CCOC(=O)N[C@H1](C(=O)NC[C@H1](C)NC(=O)[C@H1](CC)[C@H1](C)O)C(C)C COC1=CC(C(=O)N(C)C2CN(C(=O)C3=CC(Br)=C([N+1](=O)[O-1])[NH1]3)C2)=CC(F)=N1 C#CCOCCONC(=O)CN(CCOC)C(=O)CCOCC1CC1 COC[C@@H1](CCC(F)(F)F)NC1=CC=CC(C(=O)NCC2CC2)=C1 O=C(NCCN(S(=O)(=O)C1=CC=C(O)C=C1)C2CC2)C3=CC=CN=C3Br CCCOCC(=O)N1CCN(C(=O)/C=C/C2=CC=C(Cl)C(Cl)=C2)[C@H1]3C[C@H1]31 O=C(C1=CC=C2C(=C1)CN(C(=O)C3=NC(Cl)=CC=C3F)CC2[C@@H1]4)C[C@H1]5CC[C@@H1]4O5 C[C@H1](CN1C=CC=N1)C(=O)N[C@H1](CO)C(=O)NC2=CN=C3C=CC=CC3=C2 C[C@]1(C(=O)NC/C=C/C(=O)NCCCS(N)(=O)=O)CCC(=O)C1 CCN1C=CC(C(=O)N[C@H1]2CCN(C(=O)C[C@H1](C)N3N=C(C)C=C3C)C2)=N1 CC1=CC(C(=O)N2C[C@H1]3C[C@@H1]2[C@H1]3C(=O)N4CC(C)(C)[C@@H1]4C(C)C)=CC=N1 CCCC=CC(=O)N(C)C[C@H1](C)NC(=O)C1=CC2=C(N=C1O)CC[C@@H1](C)C2 CC1=C(C(=O)NC[C@H1]2C[C@@H1]2NC(=O)C3=C(C)CCCC3(C)C)[NH1]C4=CC=CC=C14 CNC(=O)C1(NC(=O)[C@H1]2CCC[C@@H1]2NCC3=CC=CN=C3)CCCC1 CC1=CC(CCC(=O)NC[C@@]2(O)CCN(C(=O)[C@](C)(O)C3CC3)C2)=N[NH1]1 C=C[C@@H1](CC)CC(=O)N(CC)CCCNC(=O)[C@H1]1CCOC2=CC=C(F)C=C21 COC1=CC=CC(C(=O)N2CC3(CCN(C(=O)C4CC(S(N)(=O)=O)C4)C3)C2)=C1C COC[C@H1]1CN(C(=O)C2=CC=CC(OC)=C2OC)CCN1S(=O)(=O)CC#N C[C@H1]1CCN(C(=O)C2=CC=C3C(=C2)CCCN3)CCN1C(=O)C#CC4CCCC4 O=C(O)C[C@@H1](CNC(=O)C1=CC=C(C2=CC(F)=CC(Cl)=C2)O1)C(F)(F)F C=CC[C@H1](C)NC(=O)[C@@]12C[C@@H1]1CN(C(=O)C=3C=CSC=3OC)C2 C#CCCC[C@H1](NC(=O)CC=1C=N[NH1]C=1)C2=CC=C(Br)C=C2 COC/C(C)=C/C(=O)N1CCC[C@](COC)(NC(=O)C2CN(C(N)=O)C2)C1 CCCNC(=O)C1=CSC(C(=O)NC2=CC=C(C(=O)O)C=C2F)=N1 COC1=CC(Cl)=CC=C1C(=O)N[C@H1]2C[C@@H1](CO)N(C(=O)C3CC4(CCOC4)C3)C2 C[C@@H1](C1CCC1)[C@@H1](C(=O)NCC2CC2)N3CCOCCC3(C)C CNC(=O)CCCNC(=O)C1([C@@H1]2CCCN2C(=O)C=3N=NSC=3C)CC1 CC=1C=C(CC(=O)N2CC[C@](CO)(C(=O)N(C)[C@@H1]3CC4CCC3CC4)C2)N(C)N=1 CC1=CN=CC=C1C(=O)N2CC[C@H1]([C@@H1]3CCN(C(=O)C(C)(C)C)C3)C2 CC[C@@H1](C(=O)NC[C@H1](NC(=O)[C@@H1]1C=CCCC1)C2=CC=CC=C2F)N(CC)CC O=C(N[C@H1]1CCN(C(=O)CCC2=NC=CO2)C1)C3=CSC(=NC4CCCCC4)[NH1]3 CCC1=CC=C(C(=O)NC2CC3(C2)CN(C(=O)COCP(C)(C)=O)C3)C(O)=C1 CC1=NS(=O)(=O)NC=C1C(=O)NC[C@@H1](O)CNC(=O)C(=O)C=2C=NN(C)C=2 CCN1C[C@@H1](C(=O)N2CCC[C@](CO)(NC(=O)C3=NC=C(C(F)F)S3)C2)CC1=O CC1=CC=C(C=CC(=O)NC[C@@H1](F)CNC(=O)C=2C=NN(C3CC3)C=2)S1 CSCCCC(=O)N1CCCC1CN(C)C(=O)CCCC(CN2C(=O)CCC2=O)C CC1=NN=C(CC(=O)N[C@@H1](C)[C@H1]2CCCN2C(=O)[C@@H1]3C[C@@H1](O)CN3C(N)=O)O1 CC1=CN=CC=C1C=CC(=O)N2CC[C@@H1]3CN(C(=O)C4=NOC=C4Cl)C[C@@H1]32 COCCNC(=O)C(=O)N[C@H1]1COCC[C@H1]1NC(=O)[C@@H1](O)[C@H1](OC)C(C)C CCOCCO[C@@H1](C)C(=O)NC1CCN(C(=O)[C@H1](O)P(C)(C)=O)CC1 CC(C)(C)C[C@H1](O)CC(=O)N[C@@H1]1CC12CCN(C(=O)COCCCF)CC2 CN1C[C@H1](C(=O)N2CC(C)(CCC(=O)N3CC(F)(F)C(F)(F)C3)C2)CC1=O CC(C)C1=NC=C(C(=O)N[C@@H1]2CCN(C(=O)CC3=CN4C=CSC4=N3)[C@H1](C)C2)S1 C[C@@H1]1CC[C@H1](NC(=O)C(C)(C)F)CN1C(=O)[C@@H1](O)C2CCOCC2 CC1=CC=C(C(=O)N2CC[C@@H1](C(C)(C)NC(=O)C3=NO[C@@]4(CCOC4)C3)C2)N1C CSCC1(C(=O)NC[C@](F)(C(=O)N(C)[C@H1]2C[C@@H1]3C[C@@H1]3C2)C(C)C)CC1 N#CC1=CC=CC(N[C@H1](CN2C=NC=N2)C3=CC=CC=C3OC)=C1 COC[C@]1(C)CCC[C@H1]1NC(=O)NC2(C3=CC=C(C)C=N3)CC2 CC1=CC=C(C(=O)N[C@@H1]2CN(C(=O)C3=CN=C4C=CC(Cl)=CN34)C[C@@H1]2F)C(Cl)=C1 COC(=O)C[C@H1](NC(=O)[C@H1]1CSCCN1C(=O)C[C@@]2(C)CCOC2)C3CC3 CCN(C)CCC(=O)N[C@@H1]1CN(C(=O)[C@@H1](C)P(C)(C)=O)C2(CCOCC2)C1 O=C(NCCNC(=O)[C@@H1]1CC=CCC1)C2=CSC=C2 CCCNC[C@@H1]1CCCN(N(C)CCCOC2=CC=CC=C2)C1 CCCC(=O)N1CC[C@@H1](C2=CN(CC3=CC=C(C(=O)O)C=C3)N=N2)C1 C[C@]1(CNC(=O)C2=CC(F)=CS2)CN(C(=O)CCSC3=CC=CC=C3)CCO1 CCCC1(C(=O)N[C@@H1](C)[C@@]2(O)CCN(C(=O)C=3C=CN(O)C(=O)C=3)C2)CCC1 CC=1C(C(F)(F)F)=N[NH1]C=1C(=O)NC2(C3CN(C(=O)C4(C)CC(C)C4)C3)CC2 CC[C@@H1](CN(C)C(=O)CC=1C(C)=NOC=1C)NC(=O)C=2C=C(C)N(C3CC3)N=2 N#CC1=NN=C2C=CC=CC2=C1NC[C@H1](CNC(=O)CN3C=CN=N3)C(F)(F)F CCCC[C@@H1](CC)CNS(=O)(=O)C1=CN=C(N2CCCCCCC2)C=C1C CC=1OC(C(C)C)=CC=1C(=O)N2C[C@@H1](C)[C@H1](CCNC(=O)C3(CCO)CC3)C2 CCOCCNC(=O)[C@H1](C1=CC=CC=N1)N2CCC[C@H1]2CN3CCCCCC3 CO[C@](C)(C(=O)N1CCC[C@]2(CCN(CC3CC3)C2)C1)C(C)C N#CC1(C(=O)NC[C@@H1]2CC[C@@H1]2NC(=O)C[C@@H1]3COCCN3C(=O)[C@H1]4C[C@@H1]4N)CC1 C=CCCO[C@H1](C)C(=O)N1C[C@@H1]2CN(C(=O)CC3=NN=C(S)N3C)C[C@]2(C)C1 CC=1N=CSC=1CC(=O)N[C@](C)(C(=O)NCCNS(C)(=O)=O)C2CCC2 CC1=CC(C(=O)N2CCCC[C@H1]2CN(C)C(=O)CCC3=CC=CC=C3O)=N[NH1]1 CCC1([C@@H1](C(=O)NCC(C)C)N2CCC3(CC2)C[C@@]3(F)Br)CC1 COC1(C(F)F)CC(C(=O)N2CC3(C2)SCC[C@H1]3NC(=O)C(C)=CC4CC4)C1 CCC1=NC(C)=C(C(=O)NCC(C)(C)CC2CN(C(=O)[C@@H1](C)C(C)C)C2)O1 CC1=NC=NC=C1C(=O)NC[C@@H1]2CCCC[C@@H1]2NC(=O)CN(C)C(C)C CC(=O)C1=CC(C(=O)N2CCC[C@H1]([C@H1](C)NC(=O)C3=CC=NC(C)=C3)C2)=CS1 N=C1[NH1]C=NC=C1C(=O)NC[C@@H1]2CN(C(=O)C3=CC(C4=CC=CO4)=NO3)CCO2 COC1=CC(C(=O)NC[C@H1]2[C@H1](C)CCN2C(=O)C3CCC=CCC3)=NC=N1 CC(C)(C#N)CNC(=O)CCN(CCO)C(=O)C[C@@H1]1CCOC1=O CC(C)C[C@H1](O)[C@@H1](C)C(=O)N(C)CCCCC(=O)N1CC[C@H1](OC2CC2)C1 O=C(CCN1N=CC2=C1CCCC2)N3[C@H1](C(=O)O)CC[C@H1]3C4=CC=C(Cl)C=C4 CN1N=CC=C1C(=O)N[C@H1]2CO[C@]3(CCN(C(=O)C4CS(=O)(=O)C4)C3)C2 C=CCC(=O)NC[C@]1(C)CCN(C(=O)C2=CC(F)=CC(F)=C2)C1 O=C(C[C@@H1]1CCCC(=O)N1)NC[C@H1]2CCN2C(=O)[C@@H1]3CCC[C@H1](O)C3 CC=1N=C(Cl)SC=1C(=O)N2CC[C@H1](C3(NC(=O)C4=C[C@@H1](O)CCC4)CC3)C2 CC1=NC(O)=CC=C1C(=O)NCCOCCCNC(=O)[C@@H1]2CCN(C)C2 O=S(=O)(C1=CC=CC=N1)N2CC[C@@H1](N3CCN(C4=CC=C(F)C=C4)CC3)C2 O=C(CCC1=C(F)C=CC=C1Cl)N2C[C@@H1]3C[C@H1]2CN3C(=O)COCC4CCCC4 C=C(C)CCNC(=O)CCC1CCN(C(=O)C=C(C)C2=CC=CO2)CC1 O=C(NC1(C2CN(C(=O)[C@@]3(C(F)F)CCCO3)C2)CC1)C4=CC=C(Cl)C(Cl)=C4O CC1=C[NH1]C=NC2=NC(N(C(=O)C3=CC=NC(F)=C3)[C@H1]4C[C@@H1](NC(=O)CC#N)C4)=C12 CCS(=O)(=O)C1=CC=CC(NC(=O)NC2=CC(Br)=CC(C(=O)N(C)CC)=C2)=C1 CCC1=NN(C)C(CNC(=O)C(=O)NCC[C@@H1]2CCC[C@@H1]3C[C@@H1]23)=C1Cl CCC[C@H1](CC(C)C)C(=O)N[C@H1]1CN(C(=O)CC2=CN=C(C)S2)C[C@@H1]1C(F)F O=C(NC1=CC=CC=C1CC2=CC=C(Cl)C=C2)C3=CC=C4N=CC=NC4=N3 CC1=CC(N2[C@H1]3CCC[C@H1]2CN(C(=O)[C@H1]4COC5=CC=CC=C54)CC3)=NC(Cl)=N1 CC1CC(CCC(=O)NCC(NC(=O)CN2C=C(Cl)C(C)=N2)C3CCCCC3)C1 CCN(CC(=O)NC[C@@H1](F)Br)C(=O)[C@H1](C)S(C)(=O)=O C[C@@H1]1C[C@H1](N=C2[NH1]C3=C(C(=NCCCOC4CCCC4)[NH1]2)SCC3)CS1 C[C@@]1(C(=O)NC[C@@]2(C)CCN(C(=O)CC3=CC=C(Cl)C=N3)C2)CC(C4CC4)=NO1 CC1=CC=CC([C@@H1](C)C(=O)N2C[C@H1](O)C[C@H1]2CNC(=O)CC3CCCCCC3)=C1 CC[C@H1]1CCN(C(=O)C=2SN=NC=2C)[C@@H1](C(=O)NC3=CN=C(Cl)C(C)=C3)C1 C[C@]1(C(=O)O)C=CCCN1C(=O)[C@@H1](N)CCS(N)(=O)=O N#C[C@H1]1CC12CCN(C(=O)C3=CC=CN=C3Br)CC2 COC=1C=CSC=1C(=O)N[C@@H1](C)CCCCNC(=O)CC2=CC=C(C(N)=O)N=C2 CNC=1SC=NC=1C(=O)NCC=2C=COC=2C(=O)NCC3=CN=CN3CC CN1C=NC(C(=O)N2C[C@H1]3CC[C@@H1](C2)[C@@H1](NC(=O)[C@H1]4C[C@@H1]4C=5C=CN(C)N=5)C3)=C1 C[C@@H1]1CCN(C(=O)CC2(O)CCOCC2)[C@H1](C(=O)N3C[C@H1](C)CC[C@H1]3C)C1 CCN1N=C(C(=O)N[C@@H1]2CN(C3=NC4=C(C=C3Cl)C(=O)OC4)CC[C@H1]2C)C=C1C C=CCOCCN=C(NC[C@@H1](CC(=O)OC)C(C)C)N1CC[C@](F)(C#N)C1 CCC1=NC(=N)[NH1]C=C1C(=O)N[C@H1]2CCN(C(=O)[C@]3(C(F)(F)F)CCCCO3)C2 CCCOC1=C(Cl)C=C(C(=O)NC2=NN=C(C(C)(C)CC)O2)C=C1OCC C#CC(C)(C)C(=O)N1CC[C@@H1](N(C)C(=O)COCC2=CC=CN=C2)C1 CCCC(C)(C)CC(=O)N[C@@H1]1CN(C(=O)C2=CN(C)N=C2C)C(CC)(CC)C1 C[C@H1](C(=O)N1CC[C@H1](NC(=O)C2=CC=NC=C2N)[C@@H1](C)C1)C3=CC=CC(Br)=C3 NC(=O)[C@@H1]1C[C@@H1](O)CN1C(=O)CC2=CSC=C2C3=CC=NC=C3 C=CCC1(C(=O)N2CC3(CCN(C(=O)COC4=CC=C(F)N=C4)CC3)C2)CCC1 C#CCN(CC(=O)NCCN(C)C(=O)C1CC1)C(=O)C=CC2(C)COC2 CC(C)=C(F)C(=O)N[C@](C)(CNC(=O)[C@H1](C)C1=CC=C2C(=C1)OCO2)C(C)C C[C@@H1](O)C=1N=C(C2=CC=C3C(=N2)OCCO3)N(C4=CC=C(Cl)C(C(F)(F)F)=C4)N=1 CCC1(O)CN(C(=O)C2=C(CNC(=O)C3(C(N)=O)CC3)C=NN2C)C1 CC1(C)CN(C(=O)N[C@H1](C)C2=CC=C([S@](C)=O)C=C2)C1 CCO[C@H1](C(=O)NC/C=C/CNC(=O)[C@H1]1CCN(C)C1)C2=CC=CC=C2 C#CC1CCC(NC(=O)C(=O)N[C@@H1](C)C2=CC=CC(C3=CC=NC=C3)=C2)CC1 CC1=CC=NC(N2CC(C)(C)C[C@H1]2CNC(=O)[C@H1](F)CC3CCCCC3)=C1 CC1=CC=C(CNC(=O)C2=CN=C3C=CC(C4=CC=NC=C4F)=CN23)C=C1C CC(C)C=1N=NSC=1C(=O)NCC[C@@H1]2CN(C(=O)[C@@H1](C)N3C=CN=C3)C[C@H1]2C CC(C)(O)CCNC(=O)C1=N[NH1]C2=C1CN(C(=O)[C@]3(CO)CCCCO3)C2 CC1=NC(CC(=O)NC[C@@H1]2CN(C(=O)C3=C(F)C=C(N)C=C3F)CCO2)=C(C)S1 CC(=O)NC1=CC=CC(N2N=C(C3=CC=C(C)O3)N=C2CN4CCOCC4)=C1 CC1CCC(C(=O)N2C[C@H1](C)[C@@H1](CCNC(=O)C3=CSC(F)=C3)C2)CC1 CC1=CC(C(=O)N2CC[C@@H1](CO)[C@H1](NC(=O)[C@H1](C)CC3=CC=NC=C3)C2)=C(C)O1 CCS(=O)(=O)CC(=O)N[C@@H1]1C=C[C@H1](CC(=O)NCCOC2CCCCC2)C1 CC(C)OC(=O)[C@H1](C)NC(=O)[C@H1]1C[C@H1]1C(=O)NC2=NC=C(Br)C=C2OC(F)(F)F CC[C@H1]1C[C@@H1](C(=O)NCC2(CNC(=O)C3=CC=C(C(=O)OC)[NH1]3)CC2)CCO1 O=C(NC1(CNC(=O)[C@@]2(Cl)CC2(F)F)CC1)C3=CC4=CN=CC=C4[NH1]3 C#CC1=CC=CC(OCC(=O)N2CCOC[C@@H1](NC(=O)C3(OC(C)=O)CC3)C2)=C1 CC(C)(C)COCCC(=O)N1CCC[C@@H1](CC(=O)NC2CC(=O)NC(=O)C2)C1 COC1=CC(CO)=CC=C1NC(=O)C[C@H1]2COCCN2C(=O)CN(C)C CC(C)(C)C1=NC(C(=O)NCCCC[C@H1](CO)NC(=O)CCF)=C2C=CC=CN12 CC(=CC(=O)N1CCC(O)(CO)CC1)CNC(=O)C2=CC=CC(F)=C2O CCC(C)(C)C(=O)N1C[C@H1](F)[C@H1](NC(=O)C=2OC=NC=2C(F)F)C1 COC(=O)CCCC(=O)N[C@H1](C)CCNC(=O)C1=CC=CC=C1CO CS[C@@H1](C(=O)NCC=1C=COC=1C(=O)N2CC3(C2)CC(C)(O)C3)C4CC4 CCC=1C=C(C(=O)N2CC(N3C[C@@H1](NC(=O)C45CC(C)(C4)C5)CC3=O)C2)N(C)N=1 CN1N=C(C(=O)N2CC[C@@H1](NC(=O)C[C@@H1]3CC(C)(C)CCO3)C2)C=C1Br CCSCC1=CC=C(C(=O)N[C@H1]2CC23CC(NC(=O)[C@@](C)(OC)C4CC4)C3)C=C1 CC[C@H1](COC)C(=O)NCC1=CCCN(C(=O)C2=CC(OC)=NS2)C1 COC1=CC=CC(F)=C1C(=O)NC[C@@H1]2C[C@@]3(CN2C(=O)C=CCO)CC3(F)F C=CCCCCCC(=O)NC[C@@H1]1CC[C@@H1]1NC(=O)[C@H1]2C=CCCC2 CCCC[C@H1](CC(=O)N[C@H1](CC)CC(F)(F)F)NC(=O)C1CS(=O)C1 CC1CN([C@@H1](C)C(=O)N2C[C@H1](C)[C@@](C)(C(=O)N(C)C[C@@H1](O)CO)C2)C1 C[C@@H1]1[C@H1](NC[C@@H1]2CCCC(C)(C)O2)C3CCN1CC3 CN1C(=O)N(CC(=O)OCC2=CC(Cl)=CN=C2Br)C3=CC=CC=C31 COC[C@H1](C(=O)N[C@@H1]1CC12CCN(C(=O)CC3=CC(O)=NC(O)=N3)CC2)N(C)C C=CC[C@@]1(NC(=O)C=2C=C3N(N=2)CCNC3=O)CCN(C(=O)C4(Br)CC4)C1 O=C(CCNS(=O)(=O)C1=CC=CC=C1)N[C@@H1]2C[C@H1]3C[C@H1]2CN3C(=O)C4=CSC=N4 CC1=CC([C@H1](C)C(=O)N2CC[C@H1](NC(=O)C3=CC(F)=CC=C3Cl)[C@@H1](C)C2)=C(C)O1 CSC=1C=CSC=1C(=O)N[C@@]23CCN(C(=O)C4=CN=CC(O)=C4Cl)CC[C@@H1]2C3 CC1=CC=C2OC(C(=O)N(C)CCOCCNC(=O)[C@](C)(O)C(C)(C)C)=CC2=N1 C[C@@](O)(CNC(=O)C1=CC=C(CNC(=O)C2=N[NH1]C=C2[N+1](=O)[O-1])O1)C3CCCC3 O=C([C@@H1]1CC[C@@H1](O)C1)N2CC3(CCC(NC(=O)C4(CN5CCCC5)CC4)CC3)C2 CC1=CC(C)=NC(CN2CCCC[C@@H1](NC(=O)C3=NN(C)C=C3C)C2=O)=C1 CN(CCCN=C1C=CC(C(F)(F)F)=C[NH1]1)C(=O)C=2C=NN(C(F)(F)F)C=2 C=CCOCCN=C(NC[C@H1]1COC(C)(C)C1)NC[C@]2(OCC)CCCOC2 CN1C=CC(S(=O)(=O)N2CCC[C@](C)(C(=O)NCC(=O)N(C)C)C2)=N1 CCC1([C@@H1](C(=O)N[C@H1](C)C2=CC=CC=C2)N3[C@H1]4CC[C@H1]3CC(F)(F)C4)CC1 CC1=CC=C(F)C(C(=O)NOCC(=O)N2CCN3N=CC(C)=C3C2)=C1 CC(C)[C@@H1](CNC(=O)[C@@H1](C)CC1CC1)N=C2C=CC(C#N)=C(C(F)(F)F)[NH1]2 CC1(C)C2=CC=CC=C2C[C@@H1]1NCC[C@H1]3COCCO3 CN1C=C2C(=N1)C[C@@H1](C(=O)N[C@@H1]3C[C@@H1]4CC[C@H1](C3)N4C(=O)OC(C)(C)C)CC2 CC[C@](C)(CNC(=O)CC1=CSC(C)=N1)NC(=O)[C@@H1]2C[C@H1]2CF C[C@H1](CCNC(=O)CS(=O)(=O)C1=CC=CC=C1)N(C)C(=O)C=2C=NN(C)C=2F CCC1=CC(C(=O)N[C@@H1]2CCCN(CC3=CC=C(C)C(O)=C3)[C@@H1]2C)=NO1 C[C@@H1](O)C(=O)N1CCC2(CC1)CCN2C(=O)[C@@H1](C)SC3=CC=CC=C3 O=C(OCC1=CC=C(O[C@H1]2CCOC2)C=C1)C3=CC=C(Cl)C(Br)=C3F COC=1C=C(C(=O)NC[C@H1]2C[C@@H1]3CC[C@H1](C2)N3C(=O)[C@@H1]4CC5=NN=CN5C4)ON=1 COC1=CC=C(C(=O)N2CCC3(CC2)CCN3C(=O)[C@H1](O)C(C)(C)C)C(OC)=N1 CC[C@]1(C)C[C@H1]1C(=O)NC2(C(=O)N3CC[C@]4(CCCCO4)C3)CCC2 CN(CC(=O)N1C[C@H1]2[C@H1](CNC(=O)[C@@]34C(=O)[C@H1]5CC[C@H1]3[C@H1]4C5)[C@H1]2C1)S(N)(=O)=O O=C(NC[C@H1]1COCCN(C(=O)C=2N=NN3C=2CCC3)C1)[C@@H1](O)CC(F)(F)F CCC=1SC=NC=1C(=O)N[C@@H1]2CCCC[C@H1]2NC(=O)C3=NC(C4CC4)=NC=C3Cl COCCN1N=CC=C1C(=O)N[C@H1](CNC(=O)[C@@H1]2C[C@H1]2C#N)C3CC3 CCC1=C[NH1]N=C1C(=O)N[C@H1](CC2CCC2)C(=O)N[C@H1]3CCC4=NC=NN4C3 CC[C@H1]1CCC[C@H1]1NC(=O)C2(C3=CC=CC=C3)CC(F)(F)C2 CC(C)=CCCC(=O)NC[C@H1]1CN(C(=O)CN[C@@]2(CO)CC23CCC3)CCO1 C[C@@H1](O)[C@@H1](C)C(=O)N(C)CC1CN(C(=O)CC2=CC=CC=C2Cl)C1 CC(C)=C(C)C(=O)N1CCC=2N=C(CNC(=O)CCC3=NC=NN3C)SC=2C1 CCOCCOCCC(=O)N1CC[C@H1](NC(=O)CCCCC(C)(C)C)[C@H1]1CC CSC(C)(C)CC(=O)N(C)[C@@H1]1CC[C@H1](NC(=O)C2=CN(C3=CC=CC=C3)N=N2)C1 COC1=CC=CC(OC)=C1CC(=O)N[C@@H1]2CCN(C3=NN=C(C#N)S3)C[C@@H1]2C CC[C@]1(C)CC[C@H1](C(=O)NCC(F)CCN(C2=CC=C([N+1](=O)[O-1])C(OC)=C2)CC)O1 CC1=CC(CC(=O)N2[C@H1]3CC[C@H1]2CC(F)(CNC(=O)C=4SN=NC=4C)C3)=NO1 C[C@H1](CS(C)(=O)=O)C(=O)N1CC[C@H1](NC(=O)C2(C)CS(=O)(=O)C2)C(C)(C)C1 COC(=O)N(C)CCN=CC=CC1=CC=C(C(F)(F)F)C=C1C(=O)N N#CC1=CC=CC(C(=O)N[C@@H1]2CCN(CC3=CC(F)=CC=C3Br)C[C@H1]2F)=C1 C#C[C@@H1]1CCCN1C(=O)CC[C@@H1]2CCCCN(C(=O)C3=CN(CC)C=N3)C2 CN(CCCN(C)C(=O)CC1CCCC1)C(=O)CCC2=CC=C(O)N=C2 CC1=NC(=N)[NH1]C=C1C(=O)N2CCC[C@]3(NC(=O)C4=CN=C(C(C)C)[NH1]4)C[C@H1]3C2 O=C1CN(CC2=CON=C2C3CCC3)[C@@H1]4C=CC[C@H1]4O1 CN1N=C[C@H1](CC(=O)NC[C@H1]2CCCC[C@H1]2C(=O)NCC3(C#N)CCC3)C1=O COCC1(CNC(C)=O)CCN(CC2=NN=C(C)O2)CC1 CCOC(=O)CCN1N=NN=C1C(C[C@@H1](O)CO)CN[C@H1]2CC[C@@H1](OC)C2 C[C@@]1(NC(=O)C#CC2CCCCC2)CCN(C(=O)C3=NC4=CC=CC=C4S3)C1 C[C@@]1(C(=O)N[C@H1]2CCCN(C(=O)CC3=NC(=N)[NH1][NH1]3)C2)CCCNS1(=O)=O C[C@H1](NC(=O)C1=CC=CC2=CC=NN12)[C@@H1]3CN(C(=O)CC4(C)CC4)CCO3 CCCCC1=NC=C(C(=O)N(C)C2CCN(C(=O)C3(C)CSC3)CC2)S1 CCN(CC)C(=O)CN(C)C(=O)C1=NC=C(C(C)C)C=C1 COC=1SC=CC=1C(=O)N[C@@H1]2C[C@H1]2NC(=O)C3=C(C)C=CC=C3F CC(C)CC/C=C/C(=O)N(CCNC(=O)CCC1=CC=C(F)C=C1)CC2CC2 CC1=CC(C)=C(O)C(NC(=O)[C@@H1]2CC[C@H1](CNC(=O)CCC3=CN=CS3)C2)=C1 CC1=CN=C(C(=O)N2CC(C3(NC(=O)C45[C@@H1]6CC(C[C@H1]64)C5(F)F)CC3)C2)C(F)=C1 CCOC1=C2C=C(Cl)C=C1CCN(C(=O)NC3=CC=CC(C4=NC(=O)O[NH1]4)=C3)C2 C#CC1=CN=CC(C(=O)N2CCSC[C@@H1]2C(=O)NC[C@@H1]3CCN(C4CC4)C3)=C1 CC1=CC=NN1[C@H1](C)C(=O)N2CCCC[C@@H1](NC(=O)CC3=CC=CO3)C2 O=C(NC1CC(O)(CO)C1)[C@@H1]2COCCN(C(=O)C=3C=CC4=C[NH1]N=C4C=3)C2 CCC[C@H1](C(=O)NC[C@@H1]1CCN(C(=O)C[C@H1](C)C2=CC=CO2)C13CC3)C(=O)OC O=C(O)CC1=CC=CC=C1CNC2CC(NC(=O)C3(O)CC3)C2 COC1=CC=CC(C=CC(=O)NC[C@@]2(C)CN(C(=O)COC(F)F)CCO2)=C1 CC1=CC=CC=C1C(=O)N[C@H1]2C[C@H1](NC(=O)C3=NC=CC(Cl)=C3O)C2 CC1=CC=NC(O)=C1C(=O)N2CC[C@@H1](C3=CN(C4=NC=C(Cl)C=N4)N=N3)C2 CC(C)C1=CC(C(=O)N2CCN(C(=O)[C@@H1]3C[C@H1]4C=C[C@@H1]3C45CC5)C[C@H1]2CO)=NO1 CO[C@@H1](C)CC(=O)N[C@@H1](CNC1=NC=CC=C1C)C(C)(C)C CO[C@H1]1C[C@@H1](CCNC(=O)C[C@H1](C)[C@@H1]2CCCO2)N(C(=O)C3=NN=CC=C3C)C1 COC(=O)C1=CC=C(CN2CCN(C3=NC=NC(C(F)(F)F)=C3Br)CC2)C(Cl)=C1 CC(C)CC1(O)CN(C(=O)[C@]2(C)CN(C(=O)[C@H1]3CCOC(C)(C)C3)C[C@H1]2C)C1 COCC1(NC(=O)CCCCN(C)C)CN(C(=O)C2CC(C)(C)OC(C)(C)C2)C1 COC(=O)C1=C[NH1]C(C(=O)N[C@@H1]2CCN(C(=O)[C@H1](O)C3=CC=C(Cl)C=C3)C2)=C1 CCC=1N=C(NC(=O)C(=O)N[C@@H1](C)C2=CC=CC(F)=C2C)SC=1C CCS[C@H1](C)C(=O)N[C@H1]1CN(C(=O)[C@H1]2CC[C@H1](N=[N+1]=[N-1])CC2)CC[C@@H1]1C CC1=CC(O)=C(C(=O)N2CCCC[C@@H1](NC(=O)COC=3C=CON=3)C2)N=N1 CC[C@H1](CC(=O)N[C@@H1]1C[C@H1]1NC(=O)C23CC4C[C@](C)(C2)C[C@@](C)(C4)C3)OC CC(C)(C)OC(=O)[C@]1(O)CCCN(C(=O)[C@H1]2CC3(CCCCC3)CO2)C1 CCN1[NH1]N=NC1=NC[C@@H1]2CCN(C(=O)C=3SC4=NC=CC(C)=C4C=3C)C2 CC[C@H1](O)C(F)(F)C(=O)N1CC[C@@]2(NC(=O)C(=O)C3=CC=C(Cl)S3)CCC[C@@H1]12 CCN1C=C(C(=O)N2CCN(C(=O)CCNS(=O)(=O)CC)C[C@H1]2C3CC3)C(C)=N1 CC1=C(Cl)C=CC=C1C(=O)N2CC[C@@H1](NC(=O)C=CC3=CC=NN3C)[C@H1](C)C2 CC(C)(C)OC(=O)N[C@H1]1C[C@@H1](CCC(=O)NC2=CN=C3C=CC=CC3=C2I)C1 CC1=NC(C)=C(C(=O)N(C)[C@@H1](C)CCNC(=O)C2=CC(Br)=CN=C2N)O1 CC1(C)CO[C@H1](C(=O)N2CCCC[C@@H1]2C3(NC(=O)CC=4SC=CC=4Cl)CC3)CO1 CC1(C)CC[C@@H1](C(=O)NC[C@@]2(C)CCN(C(=O)C(=O)NCC(F)F)C2)C1 C[C@@H1]1[C@H1]2C[C@H1]([C@H1]2NC(=O)CCCCN(C)C)N1C(=O)C3(C)COC3 CC1=NOC(Cl)=C1CC(=O)N[C@H1]2C[C@@H1](NC(=O)[C@@]3(C)CC3(F)F)C2 CCCC(=O)N[C@]1(C)C[C@H1](NC(=O)[C@H1]2CCCN(C(=O)C(C)(C)C)CC2)C1 CNC(=O)N[C@@H1](C)C(=O)NCCC1CN(C(=O)C2=CC(C(F)(F)F)=NO2)C1 CCC1=CSC=C1C(=O)N[C@@H1]2CN(C(=O)CCC3=C[NH1]C(=N)[NH1]3)C[C@@H1]2F CC[C@H1]1CN(C(=O)C2=CC3=NC(Cl)=CC=C3O2)CC[C@H1]1NC(=O)C4(C)CCCC4 C[C@](CO)(CNC(=O)C1=CC=CC2=CC(F)=CC=C12)NC(=O)CCNC(N)=O O=CN1C=NC(CC(=O)NC[C@@H1]2C[C@H1](NC(=O)C3CC4(CCOCC4)C3)[C@H1]2C)=CS1 N#CC1=CC=CC([C@@H1]2CCN(SCC=3N=N[NH1]N=3)C2)=C1 CN(C(=O)C1(F)CCCCC1)C2CN(C(=O)CC3CCSCC3)CC24CC4 CC(C)(C#N)CNC(=O)C[C@H1]1CN(C(=O)C2=CC=CN=N2)CCO1 C=CCC1(NC(=O)C(=O)N2CC[C@H1](C)C2)CN(C(=O)C3=C[C@@H1]4CCC[C@H1]34)C1 CCC1=CN=C(C(=O)N2CCN(C(=O)CC3=CSC(COC)=N3)C[C@H1](O)C2)N=C1 CC1=CC=CC(CNC(=O)COCCNC(=O)[C@@H1]2[C@@H1]3CC[C@H1](F)[C@@H1]32)=C1 CCO[C@@H1]1C[C@@H1]2CN(C(=O)[C@H1](F)[C@H1](C)CNC(=O)C3=CC=CC(F)=C3C)C[C@@H1]21 C[C@H1]1OCC[C@H1]1C(=O)NCC23CC(NC(=O)C4=CC(F)=C(F)C=C4O)(C2)C3 C[C@@H1]1C[C@@H1]1C(=O)NC[C@@H1]2CCC(C)(C)CN2C(=O)C3=CN(C(C)(C)C)N=N3 O=C(NC1CCC(NC(=O)[C@@H1]2CC=CCO2)CC1)[C@H1]3CCCC[C@@H1]3C4CC4 C=CCC[C@@H1]1CCCN(C(=O)C23CCC(NC(=O)C4=NO[C@H1](C)C4)(CC2)C3)C1 C#CC(CC)(CC)NC(=O)C1CCC(NC(=O)[C@H1]2C[C@H1]3[C@@H1](C2)C3(F)F)CC1 CCC(C)(CC)CNC(=O)C(C)(C)CN(C)C(=O)[C@H1]1OCC[C@H1]1C(C)C O=C1CCCC=2[NH1]C(=NC3CC(O)(CNC(=O)C4=CC=CC=C4)C3)C=CC=21 COC1=CC=NC(C(=O)N(C)C[C@H1](C)CNC(=O)CC2=CC(C)=NO2)=C1N C[C@H1](OC1=CC=C(Cl)C=C1)C(=O)N[C@H1]2CN(C3=NC=CC(C#N)=N3)C[C@@H1]2F O=C(N[C@H1]1C[C@@H1]2CN(CC3=CN=C(Cl)C(Cl)=C3)C[C@@H1]2C1)C4=CN=C5C=COC5=C4 CN1C=CC=C1C=CC(=O)N2CCN(C(=O)CCC(F)(F)F)[C@@H1](CC(C)(C)C)C2 O=C(CCC=1C=CON=1)N2CC[C@@H1]3CCN(C(=O)C4=CC=C(CC5CC5)S4)[C@@H1]3C2 CC(C)(CNC1=CC=C(S(=O)(=O)NC[C@@H1]2COCCO2)C=C1C#N)N3CCCC3 CC#CCCC(=O)NC1CC2(C1)CC(NC(=O)[C@H1]3CCN4N=NC=C4C3)C2 CCC[C@H1](CNC(=O)/C=C/[C@@H1]1CCCN1C)NC(=O)CC2=CC=CN=C2C CC1=CN=CC(F)=C1C(=O)N(C)C[C@H1](C)NC(=O)C2=CC=C(F)C(N)=C2F CC=1C=C(C(F)F)OC=1C(=O)N2CCC(N(CCO)C(=O)[C@H1]3CCCN3C)CC2 CCC1=CC(F)=CC(NC(=O)C[C@@H1]2CCN(C(=O)C3[C@H1](C)[C@H1]3C)C2)=C1 CCCC1=NC=C(CN2C[C@@H1]3C[C@@]3(C(=O)NC4=CN=C(Cl)C(Br)=C4C)C2)S1 CCC(C)(C)[C@@H1](C)CC(=O)N[C@@H1]1CCCCC[C@H1]1NC(=O)C2=C(C)C=CC=C2Cl COC1=C(Cl)C=C(Cl)C=C1C(=O)N[C@H1](C)[C@H1](C)NC(=O)C2=CN=NS2 CC1=NC(NC[C@@H1]2CC[C@@H1](O)C2)=CCN3CCC(CC3)NC(=O)CC4CCC4C1 C[C@@H1](NC(=O)CN1C[C@@H1]2C(CNC(=O)C(C)(C)S(C)(=O)=O)[C@H1]2C1)C3=CC=CC=C3 CCO[C@H1](CC)C(=O)N[C@@H1](C)CNC(=O)[C@@H1](C)CSC C=CC1(CC(=O)N[C@](C)(CNC(=O)CCSCC)C(C)C)CCC1 O=C([C@@H1](F)C1CCOCC1)N2CCCC[C@@H1](C(=O)N3CC(F)C3)C2 COC1(C(=O)NCCOC2CN(C(=O)[C@@H1](C)CC=3C=NN(C)C=3)C2)CCOCC1 CC1=CC=C(CC(=O)N2CC[C@H1](C(=O)N(C)C=3C=CSC=3)[C@H1](O)C2)C=N1 CC(C)C[C@H1](C)C(=O)N(C)[C@@H1]1CCCN(C(=O)C=2C=NN(C(C)C)C=2)CC1 C[C@@H1](O)C1=CN([C@@H1]2CCCN(C(=O)C3(C4=CC(Cl)=CC=C4)CCCC3)C2)N=N1 CC1=CC=C(O)N=C1CNC(=O)[C@@H1](CC2=CC=CC=C2Br)NC(=O)C3=COC=N3 C[C@@H1]1C[C@@H1](NC(=O)CN2CC[C@](C)(O)C2)CCN1C(=O)C3=NC(Cl)=CS3 CC/C=C/C[C@H1](C)C(=O)N(C)CCCCC(=O)N[C@@H1](C)CS(C)(=O)=O CCO[C@@H1]1CN(C(=O)C2=CSCCO2)C[C@H1]1CNC(=O)C3=C[S@@](=O)CCC3 CC(C)(C)[C@H1](O)C(=O)N[C@@H1]1C[C@H1](NC(=O)[C@@H1]2C[C@H1]2CC3=CC=CC=C3)C[C@H1]1O CN(C[C@H1]1CCCN(C(=O)C2=N[NH1]C3=CC=CC(F)=C23)C1)C(=O)C4[C@H1]5CC[C@H1]45 CC(=O)NCCN(CC1CC1)C(=O)C2=CC3=CC=CC=C3O[C@H1]2C(F)(F)F O=C(NC1=CC=CC(Br)=N1)N2C[C@H1](O)[C@@H1](NS(=O)(=O)C(F)(F)F)C2 CCC1=CN=C(C(=O)N[C@@H1]2C[C@H1](CNC(=O)C3(F)CC4(CCC4)C3)C2(C)C)N=C1 C#CC[C@](C)(NC(=O)[C@@H1](O)CN(C)C)C(=O)NCC(Cl)=CCl CC[C@@]1(C)CC[C@@H1](C(=O)NC2(CO)CN(C(=O)CN3C(C)=CSC3=O)C2)O1 CC#CC[C@H1](NC(=O)[C@@H1](SCC)C(C)C)C(=O)NCC1=CC(C)=NO1 C[C@H1](NC(=O)COCCF)C1CCN(C(=O)[C@@H1]2CCO[C@H1]2C3=CC=CC=C3)CC1 C#CC1=CC=C(NC(=O)[C@H1](NC(=O)C2=N[NH1]C(O)=N2)C3=CC=CN=C3)C(C)=C1 O=C(COCCF)NCC1(CNC(=O)[C@@H1]2CCCC[C@@H1]2F)CC1 N#C[C@@H1]1C[C@H1](F)CN1C(=O)C[C@H1]2CC[C@H1](NCC3=CC=CC=4[NH1]C=CC3=4)CC2 CC1=CC(Cl)=C(C(=O)NC[C@@]2(C)CCN(C(=O)CN3C(=O)CCC3=O)C2)C=N1 CC(=O)NC1(C(=O)NC[C@H1]2CCN2C(=O)CCC3=CC=C(C)C(C)=C3)CCC1 CCN(CCCNC(=O)C=1C=NN2C=CC=C2C=1)C(=O)[C@H1]3CCN(C(=O)NC)C3 C[C@H1](O)C(C)(C)NC(=O)NC1=NC=CC(C(F)F)=N1 CC1=CN=CC(C(=O)N2CC[C@@H1](CCCO)C2)=C1 CC(C)N1C=C(CC(=O)N2[C@H1]3CC[C@H1]2CN(C4=NC=NC=5SC=NC4=5)CC3)C=N1 CC1=CC(C(=O)N[C@H1]2C[C@H1](CCNC(=O)[C@@H1]3CCCN3C(N)=O)C2)=NC(O)=N1 N#CC=1N=C(N2CCC(O)(CCNC(=O)C3=CN=C4SC=CC4=C3)CC2)SC=1Cl N#C[C@@]1(NC(=O)C2=CC=NC3=C2OCO3)CCN(CC4=N[NH1]C=C4Cl)C1 CCN1CC[C@@H1]1C(=O)NC[C@@H1]2CN(C(=O)C=3C=CC(=N)[NH1]C=3)CCC24CCC4 C[C@H1]C1CCN(C2=NN=C(C(=O)N[C@H1]3C4=CC=C(Br)C=C4C[C@@H1]3O)N2CCC#N)C1 CCN1C(O)=NN=C1[C@](C)(NCCC2=CC(F)=CC=C2C)C3=NN=NN3C(C)C CCOC1=CC(N[C@@H1]2CCN(C(=O)C3=C(C)C=C(O)N=C3C)C[C@@H1]2C(C)C)=NC=N1 CN(C)C(=O)CN(C)[C@@H1](C(=O)NCCC#N)[C@H1]1CCC2(CCC2)O1 CC(C)[C@H1](NC(=O)C1(CCO)CC1)C(=O)N=C2C=CN(CC(N)=O)[NH1]2 NC1=CC(C(=O)N2CCC3(CCCN3C(=O)[C@H1]4CCCS4)CC2)=CN=C1Cl CCC1=NC(C(=O)NC2CCC(NC(=O)CCCC[C@@H1](C)CC)CC2)=CS1 C[C@@](O)(CCNC(=O)[C@H1]1CCCCCN1C(=O)C=2C=C3C=CC=CN3N=2)C4CC4 CN1N=NC=C1C(F)(F)C(=O)NC[C@H1]2C[C@H1](NC(=O)CNC(=O)C3CC3)C2 CCC[C@H1](NC(=O)C=1N=NSC=1N)[C@@H1](O)C(=O)NC2CC(C#N)C2 CCC[C@H1](C(=O)N(C)[C@H1]1CCN(C2=NC3=CC=CC=C3C=C2[N+1](=O)[O-1])C1)C(C)C CN1C(O)=NN=C1CNC(=O)C2=CC=CC(CCO)=C2 CC(C)(C)[C@@H1](O)C(=O)NC[C@@]1(C)COCCN(C(=O)CC2(C=3C=CON=3)CC2)C1 O=C(C[C@@H1]1CCCC12CN(C(=O)C3=CC=C(Cl)C=N3)C2)NCCC(F)(F)F C[C@@H1]1OCC[C@@H1]1CN=C2[NH1]C(=N[C@H1](C)C3CCCC3)C4=C(N=CN4C)[NH1]2 C=CCSCC(=O)N[C@H1](C)CCC(=O)N1CC[C@@](C)(COC)C1 CNC(=O)NCCC(=O)N[C@H1]1CCCCC[C@@H1]1NC(=O)C2(C#N)CCC2 CC(=O)N[C@H1](C)C(=O)N[C@H1](CC=1C=C[NH1]N=1)C(=O)NOCC2=CC=CC(C)=N2 O=C1CC(C(=O)N[C@@H1]2CCCC23CN(C(=O)[C@]4(CO)CC4(F)F)C3)=NN1 CC[C@]1(C)C=C(C(=O)N2C[C@@H1](NC(=O)C3=CC=C(F)C(C)=C3C#N)[C@H1](C)C2)C1 CCN(C(=O)CCC[C@H1](C)O)[C@@H1]1CCN(C(=O)C[C@@H1]2CCN(C)C2=O)C1 O=C(CC1=CC=CC=C1I)NC2CN(C(=O)CC3=CN=C4C=CC=CC4=N3)C2 O=C(N[C@H1]1CCN(C(=O)C=2C=CN3N=CN=C3C=2)C1)C4CC5(CC(F)C5)C4 CCC=CC(=O)N1CCN(C(=O)[C@@H1](C)N(CC)CC)C[C@@H1]1C2=NC=C[NH1]2 C[C@H1](C(=O)N1CCC[C@H1](CNC(=O)C=CCO)CC1)C2=CC=C(C(F)F)C=C2 CC1=CC(C)=C(N)C(C(=O)N[C@]2(C)CCN(C(=O)C3=CN=CC(C(F)F)=C3)C2)=C1 CN(CCNC(=O)[C@H1]1C[C@H1](OC2=CC=CC=C2)C1)C(=O)[C@H1]3C[C@H1](F)C3 CC=1C=CSC=1CCCC(=O)NC[C@@H1](C)N(C)C(=O)[C@H1](C)C2=CC=CC=C2C CC1=CC=C2C=CC=C(C(=O)N(C)C[C@H1](C)NC(=O)C[C@H1]3CC[C@@H1](C)C3)C2=N1 O=C(N[C@@H1]1CCN(C(=O)C2=CSN=C2Cl)C13CC3)[C@@H1](O)CC4CCCC4 CC1=NC(=N)[NH1]C(C)=C1C(=O)NCCCNC(=O)C2CCN(C(C)C)CC2 C[C@@H1](CC(N)=O)C(=O)N[C@H1]1CC[C@H1](CNC(=O)C=2OC=CC=2CN(C)C)CC1 CCN(CCNC(=O)C1=NN(C)N=C1C(F)(F)F)C(=O)[C@H1](C)OC2=CC=CN=C2 CCC(CC)(CNC(=O)[C@H1](C)C(C)(C)C1=CC=CC=C1)NC(=O)CNC(C)=O C[C@@H1]1CC[C@H1](CNC(=O)CCC(C)(C)NC(=O)[C@@H1]2CC(=O)NC2(C)C)C1 C[C@@H1](CC1=CC2=CC=CC=C2O1)NC(=O)C(=O)NC[C@H1]3CCCCC34CCC4 C[C@@H1]1[C@H1](C(=O)NC[C@@]2(O)CCC(C)(C)C2)CCN1C(=O)C3CC(=C4CC4)C3 COC[C@H1](O)C(=O)N[C@]1(C)C[C@@H1](NC(=O)C2(S(=O)(=O)C3=CC=CC=C3)CCC2)C1 CC1=CC=C(CCCC(=O)N2CCO[C@@](C)(CNC(=O)C=3C=NN(C)C=3C)C2)S1 CC1=C(NC(=O)C(C)(F)F)N=NN1CC2=CC=CC(Cl)=C2 CC(C)(C(=O)NCC1(NC(=O)CO)CCCC1)[C@@]2(C)CC2(F)F O=C(N[C@@H1]1CCC[C@H1](CNC2=CC=C([N+1](=O)[O-1])C=C2)C1)C3=CC(F)=C(F)C=C3F CC[C@@H1](CCC(=O)NCC1=NC=CC(O)=N1)NC(=O)C(C)(C)C(F)(F)F C#CCSCC(=O)N(C)C[C@H1]1[C@@H1]2CN(C(=O)C[C@H1](NC)C(=O)O)C[C@H1]12 C[C@@H1](NC(=O)CCOCCN(C)C(=O)[C@@](C)(O)C1CCC1)C(C)(C)O CCCN(C)CCC(=O)N1CCC=C[C@H1]1C(=O)N2CC[C@@H1](N3C=NC=N3)C2 CCN1CCC[C@@H1]1C(=O)N2CC(CNC(=O)CCC3=CC=C(O)C=C3)C2 CC1=NC=NC=C1NC(=O)[C@H1]2CCN(C(=O)[C@H1]3CC4=CC=CC=C43)O2 CC(=O)NC1=CC=C(C(=O)N(C)CCN(C)C(=O)[C@@H1]2CCC=CCCC2)S1 CO[C@@]1(CNC(=O)C2=CN(C)[NH1]C2=N)CCN(C(=O)C=C(C)C3=CC=CO3)C1 CC=1N=CSC=1CN(C)C(=O)[C@@H1](NC(=O)COC2CC2)C3(C)CC3 O=C(N[C@H1]1CC12CC(NC(=O)C3(O)CC3)C2)[C@@H1]4CC[C@@H1](CC5=CC=CC=C5)C4 CC1(C)CCN(C(=O)C=2C=CON=2)C[C@@H1]1CNC(=O)CSS(C)(=O)=O CCC[C@@H1](CC(C)C)C(=O)N[C@]1(C(=O)NCC2=CC=CC(Cl)=C2)C[C@H1]1C CCOC1CC(C(=O)N2CCC[C@@](F)(CNC(=O)CC3=CN=CS3)CC2)C1 CCC(O)(CC)CCNC(=O)[C@@H1](CNC(=O)[C@@H1](F)C1CCCCC1)C(C)C C=C1CCN(C(=O)[C@]23CO[C@H1](C2)[C@H1](NC(=O)CN4CCC[C@@H1]4C)C3)CC1 CN(C(=O)CCOC1CC1)C2CN(C(=O)C[C@@]3(C)C[C@@]3(F)Cl)C2 CCCOCCCC(=O)N(C)CC[C@@H1](NC1=NC=C(Br)C(O)=N1)C(C)C C[C@H1](C(=O)NC[C@@]1(O)CCN(C(=O)C=2C=NN(C(F)F)C=2)C1)C3=CN=CS3 CC1(C)NC(=O)CC[C@@H1]1NC(=O)[C@]2(F)CCN(C(=O)C3(N4CCCC4)CC3)C2 C=C1CC(CC(=O)N(C)CCCOCCNC(=O)[C@H1]2C3C[C@@H1]4C2[C@@H1]4C3)C1 O=C(N[C@@H1]1CCC[C@@H1]1NC(=O)[C@@H1]2CCNC2=O)C=3C=CN4C=3CCC4 CN1CC(CC(=O)NCCCCCC2CCN(C(=O)[C@@H1]3C[C@H1]3CF)CC2)C1 CCCC(CCC)C(=O)N[C@H1](CC)CN(C)C(=O)C1=CC(C(C)C)=NO1 O=C1CCCC[C@H1](C(=O)N[C@H1]2C[C@@H1]3C[C@H1](NC(=O)CC4=CC=CN=C4)[C@@H1]3C2)C1 CCCCCC[C@H1](C)C(=O)N1C[C@H1](O)C[C@@H1]1CNC(=O)C2=CC=C(C(=O)OC)[NH1]2 CNS(=O)(=O)NCC(=O)NCC1CC(NC(=O)C[C@@H1](NC(N)=O)C2=CC=CS2)C1 CN=C1[NH1]C(=NC2CCCC3(CCCC3)C2)[NH1]C(=NC[C@H1](CCSC)OC)[NH1]1 C=CCCC(=O)NC[C@@H1]1C[C@@H1]2C[C@H1]1CN2C(=O)[C@@H1]3CCC(=O)N3CC C=CC=CCC(=O)N1CCC[C@@](C)(NC(=O)/C=C/C2=CN=C[NH1]2)C1 CN1N=CC=C1CN2CCN(C(=O)C(=O)N3CC(C)(C)[C@@H1]3CO)CC2 CN1C=C(C=CC(=O)N[C@@H1]2CCN(C(=O)CN3CCCC3)C24CCC4)C=N1 CC1=CC=C(C(=O)N[C@@H1](C)C2(O)CCN(C(=O)C3=COC(Br)=C3)CC2)C=N1 CC(C)C=1C=CSC=1C(=O)N2CC(NC(=O)C3=C[NH1]N=C3C4=CC=CC=N4)C2 CCC1=CC=C([C@@H1]2C[C@H1](C)CCN2C(=O)C[C@@H1]3CC4(CC4)CN3)O1 CC[C@H1](CC(=O)NCCC(=O)NC1=CC=CC(F)=C1)C(F)F CC1=CC=C(C=CC(=O)N2CC[C@@H1](NC(=O)C3=CC=4SC=CC=4S3)[C@H1](O)C2)S1 C#CC1=CC=NC(C(=O)N2[C@H1](CNC(=O)C3=CN=C(OCC)S3)[C@H1]4CC[C@@H1]2C4)=C1 CCOC(=O)C(=O)N1CC[C@@H1](NC(=O)C2=CC=C(OC(C)C)C(Cl)=C2)C1 CC(C)(C)OC(=O)N1CC(C2=CN=NC(NC(=O)[C@H1]3CSCCN3)=N2)C1 CCOC(=O)CC(=O)N[C@@H1]1C[C@H1]2C[C@H1]1CN(C(=O)CC3=CC=C(C)S3)C2 CO[C@@H1]1CCCC[C@@H1]1C(=O)N(C)C[C@@H1](O)CN(C)C2=NC=C(Br)C=N2 CCNC(=O)CC(=O)NC12CC(C1)N(C(=O)COCC3=CC=CC(OC)=C3)C2 CCN=C(NC[C@H1](C)OCC)NC[C@H1](C=1C=CSC=1)N(CC)CC C#C[C@H1](CC1CCOCC1)NC(=O)N2CC(O)(C3=NC(Br)=CN3C)C2 N#CC1=CC=C(NCC(=O)NC2CC(CCNC(=O)CN3C=NC=N3)C2)C=C1 COCC[C@]1(NC(=O)C2=COC(C)=C2)CCN(C(=O)C3=CC=NC(S)=C3)C1 CSCC1(CC(=O)N2C[C@@H1]3C[C@H1]2C[C@H1]3CNC(=O)[C@]4(C)CC(C)=NO4)CC1 CC1=CC(C)=C(OCC(=O)N2CCN(CC3=NC(Br)=CS3)C[C@@H1]2C)C(C)=C1 CC1=CC(C(=O)N2CC[C@H1](CNC(=O)[C@]3(O)C[C@H1]4CC[C@H1]3C4)C2)=CC=C1C(F)F N#CC1=CC=C(Cl)C=C1NC(=O)[C@H1]2CCC3(CN(C4=NC=C5[NH1]C=CC5=N4)C3)O2 CCOC[C@H1](C)CNC(=NCCOC1=CC=C2C(=C1)OCO2)NC3CCCCC3 CS[C@@H1](C)C(=O)N1CC[C@@H1](NC(=O)COC2(C)CCOCC2)C3(CCC3)C1 COC1=CC(Cl)=CC(C(=O)N[C@@H1](C)C2(O)CN(C(=O)C3=NN=C(O)C=C3C)C2)=C1 CCC[C@H1]1CC[C@H1](C(=O)N[C@@]2(C)CCN(C(=O)[C@@H1]3CCN(C)C3)C2)CC1 CCN1N=CC2=CC(C(=O)NCCOCCCN(C)C(=O)C3=CCSC3)=CN=C21 COCCNC(=O)[C@H1](C1=CC=NC(OC)=N1)N2CC[C@@]34CCCC[C@@]3(C2)C4(F)F CSC=CC(=O)N(C)[C@H1]1C[C@@H1]2CC[C@H1](C1)N2C(=O)C3=CC4=CC=CC(Cl)=C4S3 CCN1CCC[C@H1](C(=O)N(C)CC[C@H1](C)NC(=O)C=2C=NC3=N[NH1]C(C)=C3C=2)C1 O=C(CN1N=C(Cl)C=CC1=O)NC[C@H1]2C[C@H1](NC(=O)CC3=CSC=N3)C2 CC=1N=C(CCC(=O)N[C@@H1]2[C@@H1]3CC[C@H1]2N(C(=O)[C@H1]4CCC(=O)N4C)C3)[NH1]C=1C CC(C)[C@H1](O)CC(=O)N1CCC2(CC[C@H1]2CNC(=O)C3=CC(Br)=C[NH1]3)CC1 O=C(NC[C@]1(NC(=O)[C@H1]2C[C@H1](N3C=NN=C3)C2)CCOC1)C4=NC(Cl)=CS4 CCOC(=O)C1(C(=O)N[C@@H1](C)CNC(=O)C2=CC=NC=C2OC(C)C)CCC1 CC[C@H1](CC(=O)N1CCC[C@@H1]1/C=C/C(=O)N[C@H1](CO)C(C)C)SC CCC1(C(=O)NCC2=NC(C(=O)N[C@@H1](C)C3=NN=CN3C)=CO2)CCOCC1 CC1(C)C[C@H1]1CC(=O)N[C@@H1](CNC(=O)CCC2=NC=CO2)C3=CC=CC(Cl)=C3 CN(C(=O)[C@@H1]1CCN(C(=O)[C@@H1]2C[C@H1](F)CN2C)C(C)(C)C1)[C@@H1]3CCSC3 CC(C)[C@@H1](NC(=O)C1=CC(Cl)=C[NH1]1)C2CCN(C(=O)C3=CC=NC=C3)CC2 CCOCCC1=NC(C(=O)NC[C@H1](CO)NC(=O)[C@H1]2CC3=CC=CC=C3O2)=CO1 C[C@H1](O)[C@H1](C)C(=O)N1CC[C@@H1](C2CCN(C(=O)[C@]34CCC[C@H1]3CC(=O)C4)CC2)C1 C=C[C@@H1]1OCC[C@H1]1C(=O)NC[C@@H1](CC)OC2=CC(Br)=CC=C2 C[C@H1]1CN(C(=O)CC2=CC=C(O)C=C2)[C@H1]1C(=O)NC3CC(N4C=CN=N4)C3 C[C@H1](CNC(=O)C1=NC=NC(O)=C1Br)N(C)C(=O)C=2C=NN(C)C=2N CC(C)(C)C1=CC=C(C(=O)N[C@@H1](CNC(=O)[C@H1]2CC3=CC=CC=C32)C4CC4)C=C1 CN1CCC[C@@H1]1C(=O)N(CCNC(=O)C2=CN=C3N2CCCCC3)C4CCCC4 CC[C@H1](C)[C@@H1](O)C(=O)N(CCCNC(=O)C1=CC=C(Br)O1)C2CC2 CNC1=NSN=C1C(=O)N2CC[C@]3(C[C@H1]3C(=O)N=C4C=C(Br)[NH1][NH1]4)C2 C=C(C)C[C@H1](C)C(=O)N1C[C@@H1]2C[C@H1]1[C@@H1]2NC(=O)CSC3CC3 CN1CCN(CC(=O)N2C[C@H1](C(=O)NOCC3CCCC3)[C@@H1](C4CC4)C2)CC1 CCN(CCNC(=O)C1=CC=C(OC(F)(F)F)C(N)=C1)C(=O)C(C)(C)CSC CC(C)OCC1=CC=C(C(=O)N2CC[C@H1](CNC(=O)C(C)(C)O)[C@@H1](C)C2)C=C1 CC1=CC(C)=C(C(=O)N2CC[C@@]3(CC[C@@H1](NC(=O)C(C)(C)C(C)(F)F)C3)C2)O1 CC1=CC=C2C(=N1)OCCN([C@H1](C(=O)NC3COC3)C=4C=C5C=CC=CN5N=4)C2 COC[C@@H1](C)CN(C)C1=CC=CC2=CC=C(OC)C=C12 C[C@@H1]1C[C@H1](F)CN1C(=O)[C@@H1]2CC23CC(NC(=O)[C@@](C)(O)C4CC4)C3 CC1=CC=C(C(=O)NC(C)(C)CCCNC(=O)CC2=CC=CC=C2)C=C1F N#CCC(=O)NC[C@]1(F)C[C@@H1](CNC(=O)C2=CN(C3=CC=CC(Cl)=C3)N=N2)C1 C[C@H1]1CN(C(=O)C2=CC=C(F)C(C3CC3)=C2)C[C@H1]1CNC(=O)CCN4C=NC=N4 COC1=CN=C[NH1]C1=NCC2(NC(=O)C3CCCC3)CCCCC2 N#CC1=NC=C(C(=O)N[C@@H1]2CCCN(C(=O)C3=CC=C(C4CC4)C=C3)C2)S1 CN=C1[NH1]C(=NCCC(=O)NC2=CC=C(OC)C=C2)[NH1]C(=NCC(F)F)[NH1]1 C[C@@H1]1C[C@@H1]1C(=O)NC/C=C/CNC(=O)COCC2=NC(C3CC3)=NO2 O=C(NCC[C@@H1]1CCCN1C(=O)C[C@@H1]2C=CS(=O)(=O)C2)[C@H1]3CC(=O)N(C4CC4)C3 CC1=NC(CC(=O)N2CCC3(CC2)C[C@H1]3NC(=O)CC[C@H1]4CCC(=O)N4)=CO1 N#CC1=CC(C(=O)N2[C@H1](CNC(=O)[C@@H1]3[C@H1]4CNC(=O)[C@H1]43)C[C@@H1]5CCC[C@@H1]52)=CO1 O=C(C[C@@H1]1CSCCO1)N2C[C@@]3(C(=O)N4C[C@@H1]5OC(=O)O[C@@H1]5C4)C[C@H1]2CO3 CN1C=NC=C1C2=CN(C[C@H1]3CCN(C(=O)C[C@H1]4CCC(=O)NC4=O)C3)N=N2 CCC(C)(C)C(=O)NC1CC(CCNC(=O)[C@@H1](C)N2N=CC=C2C)C1 C[C@H1](OCC1=CN(CC(=O)NCC2=CC=C3OC=CC3=C2)N=N1)C(=O)O C[C@H1](NC(=O)C1(C)CCN(C)CC1)[C@@H1]2CN(C(=O)C[C@]3(O)CCOC3)CCO2 CCN(CC)CCSCC(=O)N1C[C@H1](F)[C@H1](NC(=O)C=2C=NC3=C[NH1]N=C3C=2)C1 CCN1C=NN=C1C(=O)N2CC[C@H1]3CCN(C(=O)CN4C=CC=NC4=O)C[C@@H1]32 COC1=CC=C(C(=O)N[C@@H1](CC(C)C)C(=O)N2CCCCCCC2)N=N1 C#CC[C@H1](CC(=O)NCCN1N=NC=C1C)NC(=O)[C@@H1]2CCC(F)(F)C2 C[C@@]1(C(=O)N2CC[C@@](NC(=O)C=3SC=CC=3Cl)(C4=CC=CC=C4)C2)CCCS1 CCOC1=CC=CC=C1C2=NC(C(=O)N(C)C[C@@H1](O)C3CCC3)=CS2 C#CCCCCCCCNC(=O)C(=O)N1CCN(C(=O)OCC)CC1 C#CCCCCCCC(=O)N(C)[C@H1](C)CNC(=O)C=C(C)C1=CC=C(C#C)C=C1 CC1(C)CCCC(C)(C)C1C(=O)N2CCCO[C@H1](CNC(=O)CC34CC(C3)C4)C2 CC1=NC=CC=C1C(=O)NC[C@@]2(O)CCCN(C(=O)[C@@](C)(F)C(F)(F)F)C2 CC(=O)NCCNC(=O)C(=O)N1C[C@@H1]2C[C@H1]1[C@@H1]2CNC(=O)COCC=3N=C[NH1]N=3 C=C(C)CCNC(=O)C[C@@H1](NC(=O)[C@]1(C)CCOC1)[C@@H1](C)CC O=C(NCC1=CC=NC=C1O[C@H1]2CCN(C3=NC=NN4C=CC=C34)C2)C(F)F CCCN1C=NC=C1CN[C@@H1](C2=NN=NN2CCOC)C3(C)CCCCC3 CCC[C@H1](O)C(=O)N[C@@](C)(CO)CNC(=O)C1(N=[N+1]=[N-1])CC1 CCCCS[C@H1](C)C(=O)N1C[C@@H1]2[C@@H1](CCC[C@H1]2NC(=O)C3=CC(N)=CN=C3C)C1 C[C@@H1]1CC=C(C(=O)N[C@H1](C)CC2CN(C(=O)CC3=CSC(Cl)=C3)C2)CC1 O=C(C[C@H1]1CCOC1)NCC2=CC=CC(NC(=O)[C@H1]3CCCC4=N[NH1]C=C43)=C2 CCN(C(=O)CNC(=O)CCC(C)C)[C@@H1]1CCCN(C(=O)[C@H1](F)OC(F)(F)F)C1 O=C(NC[C@]1(O)CCN(C(=O)[C@@H1]2[C@H1]3[C@H1]4C[C@H1]2C(=O)[C@@H1]34)C1)C5=CC=CC=C5 CC1=CN=CC(C2=CN(CC3CN(C(=O)COCC4=CC=CC=N4)C3)N=N2)=C1 C=CC(C)(C)CC(=O)N(CCNC(=O)C[C@@H1]1CS(=O)(=O)CCN1C)CCOCC CNN=CC(C(=O)N1CC[C@@H1]([C@H1]2CCN(C(=O)CN3C=CC4=CC=CC=C43)C2)C1)=N CC[C@H1](C(=O)NCC[C@H1](C)NC(=O)C1=CC2=CC=CN=C2C=N1)N3N=CC=C3C CN(C[C@@H1]1CCN(C(=O)C2=CSC(Cl)=N2)C1)C(=O)C(C)(C)N3CCOCC3 CN(C)[C@H1](CNC1=CC=CC=C1)C(=O)NCC2(O)CN(C(=O)C3=CC=CC=C3)C2 COC1=CC(F)=CC(CC(=O)NC[C@@]2(F)CCCN(C(=O)[C@H1]3CCCCS3)C2)=C1 CC1=C(C#N)C=CC=C1C(=O)NCC2(C(=O)N[C@H1](C)C=3C=COC=3)CC2 CCC(CC)NC(=O)C[C@H1]1C[C@@H1](C)N(C(=O)C2=CN=CC(CO)=C2)C1 C[C@@](O)(C(=O)N1CC[C@@H1](NC(=O)CCCCC2=CC=CC=C2)C13CC3)C4CCC4 CN1N=C(C(=O)N2CC(F)(CNC(=O)[C@]3(C)CCCOC3)C2)CCC1=O CC1=CC(C2CC2)=NC=C1C(=O)NC[C@@H1](NC(=O)C=3C=C(C(N)=O)[NH1]N=3)C4CC4 CC1=CC=CC(C(=O)N(C)C[C@@H1](O)CN(C)C(=O)[C@H1]2CCCN2C(C)C)=C1C CC=1C=C(F)SC=1C(=O)N2CC[C@H1]([C@@H1](F)C(=O)N(C)[C@@H1]3CCN(C)C3)C2 COCCSCC1=CC=C(C(=O)NC[C@](C)(CO)NC(=O)[C@]2(F)CC=CCC2)O1 O=C(CO[C@H1]1CCOC1)N2CCC(CCNC(=O)C3(N4CCOCC4)CC3)CC2 CCCC(=O)N1CCCC[C@H1]1C(=O)NC[C@@H1]2COCCN2C(=O)CCC3CC3 C=CCCCCCC(=O)NC1CCC2(CC1)CN(C(=O)C[C@@H1](C)[C@@H1]3CCCO3)C2 CC(C)C1=NOC=C1C(=O)NCC2[C@@H1]3CN(C(=O)C=CC4=CC=CC=C4)C[C@@H1]23 CCS(=O)(=O)C1=CC=CC=C1CCN=C2[NH1]C(=N)[NH1]C(=N[C@H1]3CCCC[C@H1]3C)[NH1]2 O=S(=O)(C1=CC=CC(Cl)=C1Cl)N2C[C@@H1]3CC[C@H1](C2)[C@@H1]3NC4=CC(C(F)(F)F)=NC=N4 CC=C(F)C(=O)N1CC(C[C@H1](C)NC(=O)C2=CC(S(=O)(=O)NCCOC)=C[NH1]2)C1 O=C(CCC1=CN=CS1)NC[C@@H1]2CCCCN2C(=O)C(F)=C3CCCCC3 C#CC[C@](C)(NC(=O)CC1CC(F)C1)C(=O)NC2CC3(C2)CC34CCC4 CC(C)(CCC(=O)N[C@H1](CNC(=O)CS(N)(=O)=O)C1CCCCC1)[N+1](=O)[O-1] COC1=CC=C(F)C(NC(=O)[C@H1]2CCCN2C(=O)C3=CC=C(C)C(Br)=C3)=N1 O=C(N[C@@H1]1CC[C@]2(CCCN(C(=O)C=CCF)C2)C1)C=3C=COC=3Cl C[C@@H1](O)CN1CCC(NC(=O)C2=CN=C3N2CCNC3)CC1 CC[C@H1]1CN(C(=O)CC2=CC=C(F)C(Cl)=C2)CC[C@@H1]1NC(=O)C3=CC=NC=C3F CC1=CC(C(=O)N[C@H1](C)[C@H1](NC(=O)CNC(N)=O)C2CCCCC2)=NC=C1C#N O=C(N[C@@H1]1C[C@@H1]2CN(C(=O)C3CC4(CC4)C3)C[C@@H1]21)C5=CC=NC(CO)=C5 CCO[C@@H1](C)C(=O)NC[C@@]1(NC(=O)C=2C=COC=2Br)CC3CCC1CC3 N#CC1=CC(O)=CC(C(=O)NC[C@H1]2C[C@H1]2NC(=O)C3=COC(Br)=N3)=C1 CCC1=NC(C)=C(C(=O)NC[C@@H1](NC(=O)C2=CSC(C(=O)OC)=N2)C(C)(C)C)O1 CC[C@@H1]1[C@@H1](NC(=O)C(C)(C)CF)CCN1C(=O)C2=CC(O)=C3C=NN(C)C3=C2 COC(=O)C1=CC(C(=O)NC[C@@H1]2CCN(C(=O)C=3OC(CO)=CC=3C)C2)=NO1 O=C(N[C@H1]1CC[C@@H1](CNC(=O)C2=CC(Cl)=C[NH1]2)C1)C3=CC=NC(C(F)(F)F)=C3 CCOC(=O)C=CC(=O)N1C[C@@H1]2C[C@H1]1CN2C(=O)C3=CN=C4N3C[C@H1](C)CC4 CCC1(CC(=O)N2CC[C@H1]3C(NC(=O)[C@@H1](C)CSC)[C@@H1]32)CCC1 CC1=CC(C#N)=C(C#N)[NH1]C1=NC[C@H1]2CCC[C@H1]2NC(=O)C=3C=C(Cl)N(C)N=3 CCC[C@@H1](O)CC(=O)N1CC[C@](F)(CNC(=O)CCN(C)C(C)=O)C1 C[C@H1]1[C@H1](NC(=O)C2=CC=C3C=C[NH1]C3=N2)CCCN1C(=O)C4=CSC=5N=NSC4=5 CNC(=O)[C@H1](C1=NC=CO1)N2CCN(C(=O)C3=COCCC3)CC2 CO[C@]1(C(=O)NCC[C@H1](C)N(C)C(=O)CC2CCC(F)(F)CC2)CCC13CCC3 CC(C)(O)[C@H1](F)C(=O)NCC1(F)CCN(C(=O)C2=CSC(C=3C=COC=3)=N2)CC1 C#CCNC(=O)[C@H1]1C[C@H1]1C(=O)NC[C@H1](CC)N(C)C(=O)C2=CC(=O)N(C)C=N2 CCCC[C@@H1](CC)CCC(=O)N[C@@H1]1CCN(C(=O)C2=CC=C(C)N=C2OC)C1 CC1(C)C[C@@H1](CNC(=O)[C@@H1]2CCCN2C)N(C(=O)C3=CC(Cl)=N[NH1]C3=N)C1 CO[C@@H1]1CC[C@H1](C)N(C(=O)NCC2=NOC(CC(F)(F)F)=N2)C1 COCC[C@@H1](CNC(=O)[C@@H1]1CCCN(C2=NC=CS2)C1)NC(=O)CC(C)(C)O C#CCCN(C)C(=O)[C@@H1](CCCOC)NC(=O)[C@H1]1COC[C@@H1]1C(N)=O CC[C@H1](C(=O)N1CCC2(CC(C(=O)NCCOCCC3CC3)C2)C1)C(F)(F)F CN1C=C(Cl)C(C(=O)N[C@H1](C(=O)N[C@H1]2CC[C@H1](O)CC2)C3=CC=NN3C)=N1 CC(C)[C@H1]1C[C@@H1](C(=O)N[C@H1]2CN(C(=O)C3=NOCC3)CCC24CCOCC4)CCO1 FC1=CC=C(N2C=CN=C2)C(NCC3=CN(CC4=CC=C(Cl)C(Cl)=C4)N=N3)=C1F C#CCCNC(=O)C12CC(NC(=O)C3=CC=C(OC)N=C3Cl)(C1)C2 CC(C)=CCC/C=C/C(=O)N[C@H1]1CCN(C(=O)C2=CCSC2)[C@@H1]1C CO[C@@H1]1CC[C@]2(C(=O)N3CC[C@H1](C)[C@H1](CNC(=O)C=4SC=CC=4Cl)C3)C[C@H1]12 COCC1=CC=CC(CC(=O)NC[C@H1](C)NC2=NC=NC=3C=C(Br)SC2=3)=C1 CC(C)(C#N)CCCC(=O)N[C@@H1]1C[C@@H1]1NC(=O)CCSCC(N)=O O=C(NCCCOC1=CC=CC(Cl)=C1Cl)C(=O)N2CCO[C@H1](CCO)C2 COC1=CC=C(C=CC(=O)N2CC[C@H1](C=3C=CON=3)C2)C(C)=C1 C[C@@H1](CNC=1[NH1]C(=NC2C[C@@H1]3C[C@H1]3C2)N=C4SC=CC=14)NC(=O)OC(C)(C)C CCOC(=O)CC1=CN(CC(F)(F)CNC(=O)C=2C(Br)=NN(C)C=2C)N=N1 CC(C)[C@H1](NC(=O)[C@@H1]1C[C@H1]1OC(C)(C)C)C(=O)N2CC[C@@H1](OC(C)C)C2 COC(C)(C)CC(=O)NCC[C@H1]1CCCCN1C2=NC(Cl)=NC=C2Cl CNC(=O)NCCCNC(=O)[C@H1](CNC(=O)C=1C=CON=1)OC C/C(=CC(=O)N1CCCN(C(=O)[C@@H1]2CCOC(C)(C)C2)[C@H1](C)C1)C(F)(F)F COC[C@H1](C)C(=O)N1CCN(C(=O)CC=2SC=CC=2C)[C@@H1](CO)C1 CC1=CC=C(C(=O)N2CC[C@@H1](C(=O)N(C)C3CC=CC3)[C@@H1]2C)C(F)=C1 CC[C@@H1](C(=O)NC[C@@H1](O)COC(C)C)N(C)C(=O)[C@@H1]1C[C@@H1]1Cl CC(C)(C)[C@@H1](CO)C(=O)N[C@@]1(C)CCCN(C(=O)C2=CC3=CC=C(Cl)C=C3O2)C1 C[C@H1](CNC(=O)C1(F)CC1)CN(C)C(=O)C2=CC=CC(NC3=CC=C(C#N)C=N3)=C2 C=CCOCCCNC1=NC=NC(N2CC=CCC(C)(C)C2)=C1C CCCN1N=C(C)C=C1C(=O)N[C@@H1](C)[C@H1]2CCCN(C(=O)C3=CC=C(Cl)O3)C2 CCC1=NN(C)C=C1C(=O)NC2(C)CN(C(=O)C3=C(C)CCCC3)C2 COCC(=O)N(C)CC1=CC=CC(CNC(=O)[C@H1](C)OC[C@H1]2CCCCO2)=C1 CCN(CC(C)(C)CNC(=O)C1CCCCC1)C(=O)[C@H1]2CC3=CC=CC(F)=C3O2 O=C(C=CCO)N[C@H1]1C[C@H1]2CC[C@@H1]([C@@H1]1F)N2C(=O)CC3=CCSC3 C[C@H1]1COC[C@@H1](CNC(=O)C2(N(C)C(=O)C3=CC=C(C(N)=O)O3)CC2)O1 O=C(C[C@@H1]1CCCCCO1)N[C@@H1]2C[C@@H1]3C[C@H1]2N(C(=O)C4=COC(C(F)(F)F)=N4)C3 O=C(NCC1=CC=C(CC2=CC=CC=C2)C=C1)C(=O)N3C4CCC3CC4 COC1=CC=CC=C1C[C@H1]2CCCN(C(=O)N[C@H1]3CC[C@H1](OC)CC3)C2 COCC1=NOC=C1C(=O)N[C@H1]2CN(C(=O)C3=CC=CN(C)C3=O)CC[C@@H1]2CO CC1=CC=C(C(=O)NC2CN(C(=O)C3(N4CCCC4)CCC3)C2)C(N)=C1 CCOC=CC(=O)N1CC(C)(C)C[C@H1]1CNC(=O)CCOC2=CC=CC=C2OC O=C(N[C@H1]1CC[C@H1](NC(=O)[C@@H1](O)C(F)(F)F)CC1)C(=O)C2=CC=CC=C2 CC1=CC=CC(CS(=O)(=O)N[C@H1]2C[C@H1](C(=O)NC3=CC(C#N)=CC=C3Br)C2)=C1 CC(=O)N1CCC(CC(=O)N(C)CCCCCNC(=O)[C@H1](C)CC(F)(F)F)CC1 CC1=C(C(=O)NC=2C=CC3=NN(C(F)F)C=C3C=2)[NH1]C4=CC=C(Cl)C=C14 CC=1C=C(C(F)F)OC=1C(=O)N2CCN(C)[C@@H1](C(F)F)C2 CN(C(=O)CCN(CC1CC1)C(=O)CO[C@@H1]2CCOC2)[C@H1](CO)C3CC3 CC1=C(C(=O)NC2(C)CC(NC(=O)[C@@H1]3CC34CCC4)C2)CCC(C)(C)C1 CC=CC[C@H1](CO)NS(=O)(=O)CC1=CC=C(C)C(C)=C1 O=C(N[C@@H1]1CC[C@@H1](NCC2=CC=C(C(F)F)C=N2)C1)C3=NC4=CC=CC=C4O3 N#CCCCC(=O)N1CCSC[C@H1]1CCNC(=O)C=2SC=CC=2C3CC3 C[C@H1](O)C1=CC=CC=C1C(=O)N2CC3(CO[C@@H1](CNC(=O)[C@@H1](F)C(C)(C)O)C3)C2 CCN(C(=O)[C@@H1]1CCN2C=NC=C2C1)C3CCN(C(=O)[C@](C)(CC)OC)CC3 COCCC(=O)N1CC[C@H1](CC2=CN(C3=CC=CC=C3F)N=N2)C1 CNC(=O)OC[C@@H1]1CCCCN1C(=O)[C@H1]2COC3(CCC3)C2 N#CC1=C[NH1]C(C(=O)N(CC(=O)NCC(=O)N2CC=CC2)CC3CC3)=C1 C[C@]1(C(=O)NC2=NC=C(Br)N=N2)CCCN1S(=O)(=O)C3CC3 COCCCC(=O)N[C@](C)(CNC(=O)CN1C=C(Br)C(O)=NC1=O)C(C)C CCC[C@]1(NC(=O)CCC2=NC=CN2C)CCCN(C(=O)CCNC(=O)NC)C1 C=CCC(=O)N1CCN(C(=O)/C=C/[C@@H1](C)CC)C[C@@H1]1C2=CC=CC=C2 COC(=O)COCC(=O)N1CC(F)(C(=O)N2C[C@@H1](C)O[C@H1](CO)C2)C1 O=C1CC(C(=O)N[C@H1]2CC[C@H1]2CNC(=O)C[C@@H1](C3=CC=CC(F)=C3)C(F)F)=NN1 CC=1[NH1]N=C(C(=O)N2CC[C@H1](NC(=O)[C@@H1]3C[C@H1]4C[C@@H1]3CC4(F)F)[C@H1]2C)C=1Cl O=C(NC[C@@H1]1CCC2=C(Br)C=CC=C21)NC[C@@H1]3CC3(F)F CCC=CC=CC(=O)N[C@H1]1CCN(C(=O)C=C(C)C2=CC=CN=C2)C13CC3 COC(=O)[C@]1(C(=O)OCC2=CC=CC(=C2)CCOC)CC1(F)F CN1C=C2C(=N1)C[C@@H1](C(=O)N[C@H1]3C[C@H1](NC(=O)CCCN=[N+1]=[N-1])C3)NC2=O CCC1=CC=C(C(=O)N2CC[C@@H1](N(C)C(=O)[C@@H1]3CCC4=CC(Cl)=CC=C43)C2)O1 CCN1N=C(C)C=C1C(=O)N2CCN(C(=O)C3=CN=NS3)C[C@@H1]2C(C)(C)C C[C@H1](NC(=O)C1CCC(=C(F)F)CC1)[C@@H1]2CCCN2C(=O)CCCSC(C)(C)C CCC1=NC(C(=O)N2CCC(C(=O)N[C@@H1](C)C3=CN=CS3)=C(F)C2)=CO1 C=CC(F)(F)C(=O)N(C)C[C@@H1](O)CN(C)C(=O)C1=CC=C2C(=C1)N=CN2C CC[C@H1](CNC(=O)C1=CC=C(N)C=C1[N+1](=O)[O-1])NC(=O)C(F)(F)[C@@H1](O)C(C)C CN1C=C(C2=CC(C(=O)N3CC4(C[C@@H1](NC(=O)[C@@H1]5C[C@@H1]5F)CO4)C3)=N[NH1]2)C=N1 CC(C)[C@]1(O)CCN(C(=O)[C@@](C)(CO)NC(=O)[C@@H1](C)C(C)(C)C)C1 CCS(=O)(=O)C=CC(=O)N1CC[C@](CNC(=O)CC[C@@H1]2CCCO2)(C(C)(C)C)C1 CN(C)C(C)(C)C(=O)N1C[C@H1]2C[C@@H1]1[C@H1]2C(=O)NCC34CCN(CC3)CC4 O=C(CCCC1=CC=CC=C1)NCCC2(CN=C3[NH1]C4=CC=C(Br)C=C4S3)CC2 CC1=CN=C(C(=O)N2CCC3(CC2)C[C@H1]3C(=O)N[C@H1](C)CC(C)C)C=C1C C=CC[C@]1(C(=O)N2C[C@@H1]3CCO[C@]3(CNC(=O)C4=CN(C)C(O)=N4)C2)CCOC1 COCC1(NC(=O)[C@@H1]2C[C@H1]2C3=CC=CC=C3)CN(C(=O)C4=CC=C(N)C(F)=C4)C1 C=CC1(C(=O)N[C@H1](C)CNC(=O)C2=CC=C(N3CCNC3=O)C=C2)CCC1 O=C1CC[C@@H1](C(=O)N2C[C@@H1](NCC=3OC=CC=3Br)C[C@@H1](F)C2)N1 COC(=O)C[C@@H1](C)C(=O)N(C)[C@H1](C(=O)NCCCN1C=CN=C1)C2CC2 CCCC=1N=NSC=1C(=O)N2CCN(C(=O)[C@H1]3OCC[C@H1]3C)[C@@H1](C4CC4)C2 CN(C)CCOCCC(=O)N[C@]1(C)C[C@@H1](NC(=O)[C@@H1]2COCC3(CCC3)O2)C1 CC1=CC=CC=C1CCC(=O)N2C[C@H1]3C[C@H1](NC(=O)C4=CN=C(O)S4)C[C@H1]2C3 CCC[C@H1](OC)C(=O)N[C@]1(CCC)CCCN(C(=O)CCCC2CCOCC2)C1 CCN1C[C@H1](C(=O)NCC2(C(=O)N[C@H1]3CCCC(C)(C)C3)CCC2)CC1=O CCC[C@@H1](OCC)C(=O)NC[C@]1(C)CN(C(=O)C2CC(C)C2)C[C@H1]1C C=C[C@@H1]1OCC[C@H1]1C(=O)N[C@]2(CNC(=O)C3=NC=C(C4CC4)C=C3C)CCOC2 C=C[C@H1](C)C(=O)N1C[C@H1](C)C[C@@H1](C(=O)NCC2=NC=C[NH1]C2=O)C1 CC(C)(C)[C@H1](CNC(=O)C1=CN(C(C)(C)C)N=N1)NC(=O)C(=O)N=S(C)(C)=O C[C@H1]1C=C(C(=O)N2CCC[C@H1]2[C@@H1](C)NC(=O)C3=NN=C(O)C=C3O)CC1 CN1N=C2C(=C1C(=O)NC3CCN(C(=O)C4(N5C=CC=C5)CC4)CC3)CSCC2 CCN1N=C(C(=O)N[C@@H1]2C[C@@H1]3C[C@H1]2CN(C(=O)CC(C)(C)C)C3)C=C1O C[C@@H1](NC(=O)CC(=O)OC(C)(C)C)[C@@H1]1CCCN(C(=O)CCC2=CC=CS2)C1 CC1=CC(=N[C@@H1]2CCO[C@@H1](C(C)C)C2)[NH1]C(=NCC3=CC=C(F)C(C)=C3)[NH1]1 CC1=CC(Cl)=CC=2[NH1]C(C(=O)N(C)CC(C)(C)NC(=O)[C@H1](F)C(F)(F)F)=CC1=2 COCC1=CN=CC(C(=O)NC[C@H1]2C[C@H1]2NC(=O)[C@](C)(CC3CCC3)OC)=C1 C=C1CC[C@@H1]1C(=O)NCC[C@@H1](C)N(C)C(=O)C2=CC=3[NH1]N=C(C)C=3C=N2 CC=1C=C(CN=C2[NH1]C(=NC[C@@H1](C)[S@](C)=O)[NH1]C3=CC=CC=C23)ON=1 CN1C(=O)CN(CC(=O)NC[C@@H1]2CN(C(=O)/C(Cl)=C/Cl)C3(CCOCC3)C2)C1=O CCCCCN=C(NCC1CC(F)(F)C1)N[C@@H1]2CCC3=CC=CC=C3C2 CC(C)(CCNC(=O)C(F)(F)C1=CC=CC(Cl)=C1Cl)NC(=O)CC[C@H1]2CCOC2 C[S@](=O)C=CC(=O)N[C@H1]1CC[C@H1](CNC(=O)CC[C@@H1]2C[C@H1]3CC[C@H1]2C3)CC1 CC1=CC=CC(N)=C1C(=O)N2CC(NC(=O)[C@H1](C)CO)(C3=CC=C(Br)C=C3)C2 CSCC[C@@H1](NC(=O)CN1N=C(C)C=C1C)C(=O)NCC2=CC=C(F)C=C2O CC1=NC(C(=O)N[C@H1]2CC[C@@H1](NC(=O)C3=CC(C4CC4)=NO3)C2)=C(C)S1 O=C(C=1C=C(C2CC2)ON=1)N3CC[C@@H1](CN4C=C(C5=CN=CC=C5Cl)N=N4)C3 CN1C=C(Cl)C(C(=O)NCCCN(C(=O)[C@H1]2CC3(CCOCC3)CO2)C4CC4)=N1 C[C@H1](CN=C1C=CC2=C([NH1]1)CC(C)(C)CC2=O)OC3=CC=CC(Cl)=C3 COC(=O)[C@@]1(F)CCN(C(=O)[C@H1]2C[C@@H1]3C[C@H1]3N2CC4=CN=CC(C)=C4)C1 CC1=NC=NC=C1C(=O)N[C@H1]2CCC(C)(C)C[C@@H1]2CNC(=O)C3=CC=C(C#N)O3 O=C1N[C@@]2(CCN(S(=O)(=O)C3=C[NH1]C=CC3=NC4CCC=CCC4)C2)CO1 COC(=O)COC1=CC=C(CN2CC[C@@H1](NC(=O)C=3C=NN(C)C=3)C2)C=C1 CNC(=O)NC1=NC(C=2C=NC3=N[NH1]C(C(=O)N4CCC(O)CC4)=C3C=2)=CS1 C[C@H1](CCNC(=O)CN1CCC[C@H1]1CO)NC(=O)C2=CN=C(C3CC3)O2 C/C=C/C[C@H1](NC(=O)[C@@H1](C)N1CCOCC1)C(=O)N(C)CC2=CC=CO2 CC[C@@H1](C(=O)N[C@H1]1C[C@@H1](C(=O)N[C@H1](C(N)=O)C(C)C)C1)C(F)(F)F COC(=O)C[C@@H1]1C[C@@H1](N[C@H1](C2=NN=NN2CCC3(C)CC3)C(C)(C)OC)C1(C)C C[C@H1]1CN(C(=O)[C@H1](F)CCC(C)(C)C)C[C@H1]1N2C=C(CN3CCCCCC3)N=N2 COCC=1C=CSC=1C(=O)NC[C@H1]2[C@H1](O)[C@H1](O)CN2C(=O)C=3C=C(C)OC=3C COC1=CC(C(=O)N2C[C@@H1]3C[C@H1]2[C@@H1]3CNC(=O)[C@H1](C)C(C)(F)F)=CC=C1[N+1](=O)[O-1] C[C@@H1]1[C@@H1](C(=O)N[C@@]2(C)CCN(C(=O)C3=CC=C(S(=O)(=O)N(C)C)N=C3)C2)C1(F)F C/C=C/C[C@@H1](CC)C(=O)N1C[C@@H1](NC(=O)C=C2CCC2)[C@H1](S(C)(=O)=O)C1 CN1N=CC(Cl)=C1C(=O)NC[C@]2(C)CCN(C(=O)[C@H1]3CC34CCC(F)(F)CC4)C2 C[C@]1(CNC(=O)C2=CC=CC=C2C#CC3CC3)CCC4=CC=CC=C4O1 CC=1C(N)=CSC=1C(=O)NCC23COC(CF)(C2)C3 O=C1C[C@H1](C(=O)NC=2C=CC3=C[NH1]N=C3C=2)N(C(=O)CC4(O)CCCCC4)C1 CCOC1=CC=C(NC(=O)C2=CC=C(Br)C=C2S(C)(=O)=O)C(OC)=N1 CC1(NC(=O)C[C@H1]2CO[C@@H1](CO)C2)CCN(C(=O)C=3C=CN4N=NN=C4C=3)CC1 COCC1(CNC(=O)C2=CSC(Br)=C2)CN(C(=O)C3SCCS3)C1 CCN(C(=O)CC=1C=C(Cl)N(C)N=1)[C@@H1](C)CNC(=O)C2=CN=C(C(C)C)N=C2C CC(C)OC(C)(C)C(=O)N1C[C@H1](C(=O)N2[C@H1]3CC[C@H1]2CC(=O)NC3)CC(C)(C)C1 CCC[C@@H1](NC(=O)C[C@H1](OCC)C(=O)O)C1=CN(C2=CC=C(F)N=C2)N=N1 C=CC[C@@H1](C)C(=O)N1CCCCC[C@H1](NC(=O)[C@H1](O)C2=CC=C(OC)C=C2)C1 CCC1=NO[C@@H1](CC(=O)N2CCCC[C@H1](CNC(=O)C3=NC=CN3C)C2)C1 CC[C@@H1](CN(C)C(=O)CSC1CC1)NC(=O)C=2N=CN(C)N=2 O=C(NC[C@H1]1CCN(C2=NC3=CC=C(Br)C=C3S2)CCC1(F)F)C4=CC(Cl)=C[NH1]4 COC1=CC=NC(C(=O)N2C[C@@H1]3CCOC[C@]3(NC(=O)CC4CC(F)C4)C2)=C1F C[C@H1](C(=O)N[C@@H1]1CN(C(=O)CCCS(N)(=O)=O)C[C@H1]1O)C2=CC=CC(F)=C2 C[C@@H1]1CCC[C@H1](N(C)CC2=CC(C[C@H1]3CC(=O)NC3=O)=CC=C2OC(F)(F)F)C1 CC[C@@]1(C(=O)N[C@H1]2COCCN(C(=O)C3=CC=CC=4N=C[NH1]C3=4)C2)CCCCO1 CC=1[NH1]N=C(C(=O)NCC2(C(=O)N3[C@H1]4C=CC[C@H1]3CC4)CC2)C=1O CCC1=C[NH1]C(C(=O)N(CCNC(=O)C#CC2(CC)COC2)C3CC3)=N1 C[C@]1(C(=O)N2CCC[C@H1]([C@@H1]3C[C@@H1]3NC(=O)C4CCOCC4)C2)C=CCCC1 C#CCC[C@@H1]1CCCN(C(=O)[C@@H1]2C[C@@H1]3CN(C(=O)CN4C=CC(C)=N4)C[C@@H1]3C2)C1 C[C@@H1](CNC(=O)CC=1C=N[NH1]C=1)CNC(=O)C2=CC=C(C(C)(C)C)N=C2 CN1CCC(C(=O)N(C)CC2(O)CCN(C(=O)C(F)(F)CO)CC2)CC1 CC1=C(Br)C=CC=C1CCNC(=O)C2=CC=C(CC(N)=O)C=C2 C[C@@](CCCl)(NCC1=CSC(C(F)(F)F)=C1)C2=NN=NN2[C@H1]3CCOC3 COC(=O)NCC(=O)NCC1(C)CCN(C(=O)C2=CC=CC(OC(F)F)=C2)CC1 C#CCC[C@H1](NC(=O)[C@H1](CC)NC(N)=O)C(=O)NCC1(F)CC1 COC[C@](C)(CCO)NS(=O)(=O)C1=CC=CN=C1NCC2=CC(Br)=CC=C2C CCOC[C@H1](C)C(=O)N1CCN(C(=O)C=2C=C(C)SC=2C)[C@@H1](COC)C1 CCCCC(F)(F)C(=O)NC[C@H1]1C[C@@H1](C(=O)N(C)[C@H1](C)C[C@@H1](C)CC)C1 C=CC(C)(C)CC(=O)N(C)[C@@H1]1CCCC[C@@H1]1NC(=O)C2=CC=C(C)C(OCC)=C2 NC(=O)C1=CN=CC(C(=O)NC2CN(C(=O)C3CC(=C(F)F)C3)[C@@H1]4COC[C@@H1]42)=C1 CCN(CC(=O)NCC1(C(N)=O)CN(C(=O)C2=CC(C)=C(C)O2)C1)C3CC3 C#CCCOCCNC(=O)[C@@H1]1[C@H1](O)CCN1C(=O)CC2=CN=NN2C CN1N=CC2=C(C(=O)N[C@@H1]3CCC[C@@H1]3NC(=O)C4=CC=NC(F)=C4)C=CC=C21 CSCCCN(C)C1=NC(=NCCC2=N[NH1]C(C)=N2)[NH1]C3=CC=CN=C13 CC1=CC=C(C2=C[NH1]C=C2C(=O)NC[C@H1]3C[C@@H1](NC(=O)C4=CSN=N4)C3)S1 CC1(C(=O)N2CC[C@@H1](CC3CCC3)C2)CN(C(=O)CC4=CC=CC=C4F)C1 CCN(CCCNC(=O)C1CC(C)(O)C1)C(=O)COC2(C3=CC=CC=C3)COC2 O=C(NC[C@@H1]1COC[C@]2(CCNC2)O1)C3=CC=CC=C3OC(F)(F)F CCCCCCN1C=C([C@@H1]2CN(C(=O)C3CC(=O)NC(=O)C3)C[C@H1]2O)N=N1 CN1C=C(C(=O)N[C@@](C)(CO)C(=O)NCCC2=CC=C(F)N=C2)N=CC1=O CCC[C@@]1(NC(=O)[C@@H1](O)CC)CCCN(C(=O)C2(C3=CC=C(C)C=C3)CC2)C1 CC1=CNN=C1C(=O)NCC2(C)CCCN(C(=O)C3=CC(Cl)=C(Cl)N3)C2 C[C@H1](NC(=O)[C@H1]1CC2(CCC2)CO1)C3CCN(C(=O)C=4C=COC=4C5CC5)CC3 C[C@H1](O)C(=O)N1CCN(C(=O)CCCC2CCOCC2)[C@H1]3CCC[C@H1]31 CN1C=C(NC(=O)C2=CN=CC(CNC(=O)C3(Cl)CC3)=C2)C=N1 C[C@H1](C(=O)N1CC(NC(=O)COC2CC2)C1)C3=CN=CS3 CC1=CC(C(=O)N[C@@H1](C(=O)N(C)CC(C)(C)CO)C2=CC=CC=C2)=C(N)S1 COC1=CC(C)=CC=C1C(=O)N[C@@H1]2C[C@H1](CNC(=O)[C@H1]3C[C@@H1](OC)C3)C24CCC4 CC1(OCC(=O)N[C@H1]2CCC[C@H1]2NC(=O)CN3CCS(=O)CC3)CCC1 NC(=O)CSC1=CC=CC=C1C(=O)N[C@@H1]2CCN(C(=O)C=3C=COC=3C4CC4)C2 C=C=C(C)CC(=O)N[C@@H1]1C[C@H1]1CNC(=O)CC=2C=C[NH1]C=2C CC=1C=CN2C=C(C(=O)N(C)[C@@H1](C)CNC(=O)[C@H1](O)C3=CC=NN3C)N=C2C=1 C=CCC1(NC(=O)CCC2=CC=NC(Cl)=C2)CN(C(=O)CC=3[NH1]C=NC=3C)C1 CC1(NC(=O)[C@@H1]2CCCN3C=NC=C32)CN(C(=O)[C@]4(O)C[C@H1](O)CN4)C1 CC(C)CC1=CC(C(=O)N[C@@H1]2COCCN(C(=O)[C@H1](C)CC(N)=O)C2)=CC(O)=N1 C[C@H1](CNC1=CC(=N[C@H1](C)[C@H1](C)N2C=NC=N2)[NH1]C(C(C)C)=N1)CN3C=CC=N3 C#CC[C@]1(O)C[C@@H1](C(=O)N2CC[C@@H1](N(CC)C(=O)C3=CC=C4C(=C3)C[C@@H1](C)O4)C2)C1 CCCC1=N[NH1]C=C1C(=O)N2CCC[C@H1](CC(=O)N[C@H1]3CC34CCCCCC4)C2 COC[C@]1(C(=O)N[C@H1]2C[C@@H1](CO)C23CCC3)C=CCN1C(=O)C4=CC=CN=C4S O=C(O)[C@H1]1CCC2=NN=C(CNC(=O)C3([C@@H1]4CCCCO4)CC3)N2C1 CCCCCCCCC(=O)N[C@H1](C)[C@H1]1CCCN(C(=O)CC(C)(C)O)C1 CCC1=NN(C)C=C1C(=O)N2CC[C@@H1](NC(=O)CN3C=CC=CC3=O)C[C@H1]2C COCCC[C@H1](N)C(=O)NC1=CC(C(N)=O)=NC=N1 COC1=CC=C(C(C)=O)C=C1NC(=O)[C@@H1](C)N[C@H1](C)CCC(F)(F)F O=C1C[C@H1](C2=CC=CC=C2)N(CC(=O)N3CCC(C[C@@H1](O)C(=O)O)CC3)C1 CCC1=C(C)N2C=NC(C(=O)N3C[C@H1](C)CN(C(=O)C=4ON=CC=4C)C[C@@H1]3C)=C2N1 CCCNC(=O)CCC(=O)N1CC[C@@H1](NC(=O)[C@@]23CCCCN2CCC3)C[C@H1]1C CC(C)COCCC(=O)N1CCN(C(=O)C23CCN(CC2)CC3)C[C@H1]4CCC[C@H1]41 CCCSCC(=O)N(CC)CC1CCN(C(=O)C2=C[NH1]N=C2C3CC3)CC1 C=C(C)[C@](C)(O)C(=O)NCC1(OC)CN(C(=O)[C@@H1]2CCOC3(CCOCC3)C2)C1 C=CCC(C)(C)CCN=C1[NH1]C(C)=CC(=NC2C=C2)[NH1]1 O=C(NC1=CC=C(C2=CN(C3=CC=CC=C3F)N=N2)C=C1)C4=NO[C@@H1]5COC[C@H1]45 CC1=CC=C2C(=C1)O[C@@H1](C)CN2C(=O)[C@@H1]3CNC4(CCOCC4)C3 COC1=CC=CN=C1C(=O)NC[C@H1](C)NC(=O)C2(C(C)(C)C)CCCC2 CC1(NC(=O)C[C@@H1]2C[C@H1]2C3=CC=CC=C3)CN(C(=O)CCC4=CSC(=N)[NH1]4)C1 CC1=COC(C)=C1CNC(=O)[C@]23CC[C@H1](C[C@@H1]2NC(=O)C[C@@H1]4CC=CCC4)C3 O=C(N[C@H1]1C[C@@H1](F)CN(C(=O)[C@]2(F)[C@H1]3CCC[C@H1]32)C1)C(=O)C4=CC=C(Cl)S4 CCN(OC)C(=O)[C@H1](NC(=O)[C@@H1](C)N1C=CC=N1)C2=CC=CC=C2 CCC(CC)C(=O)N1CC[C@H1](NC(=O)C2=CN3CCS(=O)(=O)N=C3C=C2)[C@@H1](C)C1 O=C([C@H1]1CCN2C=CN=C2C1)N3CC[C@H1](C4=CC=CC=C4F)C3=O CC[C@@H1](CCC(=O)N1CCC(SC)CC1)NC(=O)CN2C=CN=N2 O=C(NCC(F)=C1CN(C(=O)C=CI)C1)C=2C=CC3=CN=NN3C=2 CC1(C(=O)N[C@@H1]2CCN(C(=O)C[C@H1]3CCCC[C@@H1]3O)[C@H1]2C4CC4)CCC1 CC1=CC=C(C(=O)NC2(CNC(=O)[C@H1]3CNC(=O)C3)CCCCCC2)N=C1 COC1=CC=CC(CNC(=O)[C@H1]2CN(C(=O)C3=CN=CN=C3C)CCN2)=C1 CCC[C@H1](C)CCCC(=O)NC1CC2(C1)CN(C(=O)CCC3=CSC=N3)C2 CC1(CCC(=O)N2C[C@H1](C(=O)NC[C@H1]3C[C@@H1]3C4CCCC4)CCC2(C)C)N=N1 C[C@]1(C(=O)N2CC(O)(CNC(=O)CC3CC4(C3)CC5(CCC5)C4)C2)CCCOC1 CSCC[C@H1](NC(N)=O)C(=O)NC(C)(C)CCNC(=O)C1(C)CCN(C)CC1 CCN(C(=O)[C@@H1](F)CC1CCC1)[C@H1](C)CNC(=O)CN2C=NC(C(F)(F)F)=C2 CCCCN1C=C(C(=O)N[C@@H1]2COC[C@@H1]2NC(=O)C[C@H1](C)C(F)F)C(C)=N1 CC=1C=CSC=1CNC(=O)C[C@H1]2C[C@H1](NC(=O)CCC3OCCO3)C2(C)C CCOC(=O)CCNC(=O)[C@@H1](C=1N=C(Cl)SC=1Cl)N2CC[C@@](C)(NC(C)=O)C2 C[C@H1]1CN(C(=O)C2=CC(F)=C3C=N[NH1]C3=C2)CCN1C(=O)C4=CC=CC(I)=C4F C[C@@H1]1C[C@@H1](CC(=O)N2CCC(N3CCC(F)(F)CC3)CC2)CC(C)(C)C1 O=C(NCCO[C@H1]1CCN(C(=O)CN2C=NC=N2)C1)[C@@H1]3CN4CCC3CC4 C[C@H1](F)CC(=O)N(C)[C@@H1](C)CCNC(=O)C1=CC=C(OCC2=CC=CC=C2)C=C1 CC[C@@](C)(OC)C(=O)N[C@@H1](CCN(C)C(=O)C1=CC(S(C)(=O)=O)=C(C)O1)C(C)C O=C(N[C@@H1]1CCN(C(=O)CC=2C=CON=2)CC[C@H1]1CO)[C@@H1](O)CC3=CN=C[NH1]3 CC1=CC=CC(O[C@H1](C)C(=O)N2CC=C(CNC(=O)CN3C=NC=N3)CC2)=C1 CC(C)C1=NC=C2C(=N1)CCN(C(=O)CC3=CC=CN3C)C2 CCC[C@H1](CC(C)C)C(=O)N[C@@H1](C1=CC=C(O)C(C#N)=C1)C2=CN(C)N=C2C CC1=CC=CC=C1OCCC(=O)N[C@@H1](CNC(=O)[C@]2(C)C=CCC2)C(C)C CC[C@@](C)(CNC(=O)[C@@H1]1CCOC1)NC(=O)C=2N=COC=2COCC(=O)OC C[C@@H1]1O[C@H1](C)[C@H1](C(=O)NCC[C@@H1]2CCCCN2C(=O)CCN3CCCC3=O)[C@@H1]1C CCCCS[C@@H1](C)C(=O)NC[C@@H1]1CCN1C(=O)C2=CC=C(CN(C)C)O2 CC1(C)CN(C(=O)[C@]23CCC[C@@H1]2CC(=O)CC3)C[C@@H1]1NC(=O)CC4=CC=NS4 CC[C@H1](C)C(=O)NCC(=O)NC(C)(C)C(=O)N1C[C@@]23CC[C@]2(COC3)C1 O=C(NC[C@H1]1C[C@H1](NC(=O)[C@@H1]2CC23CC3)C1)C4=CC(F)=CC=C4SC5CCCC5 COC1=CC([C@@H1]2CCCN2C(=O)C(=O)NC(C)(C)C)=CC=C1F CC[C@@H1](C)N1[NH1]C(=NC(=O)C(=O)N2CCC[C@]3(CO)CCC[C@H1]23)C=C1C C[C@H1](OC1=CC=CC(Cl)=C1Cl)C(=O)N[C@H1](C)CNC(=O)C2(C)CCSCC2 C#CCC(C)(C)C(=O)NCC1(CN(C)C(=O)[C@@H1]2[C@H1]3CNC(=O)[C@H1]32)CC1 CC1=NN(C)C(Cl)=C1CN2C[C@H1]3CN(C(=O)C4=CC=CC(Cl)=C4I)C[C@H1]3C2 C[C@H1]1CN(C(=O)CN(C)C2=CC=NC(Cl)=N2)CC[C@@H1]1N(C)C(=O)C#CC3CC3 CC1=CC(C(=O)N[C@H1]2CCN(C(=O)[C@@H1]3CCCC4=NN(C)C=C43)[C@H1]2C)=C(C)S1 O=C(C1=CN=CN=C1C2=CC=C(OC(F)(F)F)C=C2)N3CC[C@@H1]([C@@H1]4OCC4(F)F)C3 C[C@H1](OC1=CC(Cl)=CC(Cl)=C1)C(=O)N[C@H1]2C[C@@](F)(CNC(=O)C3(C#N)CC3)C2 CC(=O)N(C)C1CCN(C(=O)[C@H1]2C[C@@H1]3C[C@H1]3N2CC4=CC=CC(C)=C4F)CC1 C[C@@H1]1COC[C@H1](C(=O)N2CC[C@H1](C(=O)N3CCC[C@H1]4[C@H1](O)C[C@H1]43)C2)O1 C[C@@]1(CNC(=O)CCC2=CC=CS2)CCN(C(=O)CC=3C=NN(C(F)F)C=3)C1 C[C@H1]1CC[C@H1](NC(=O)C2=CC(N)=CC(O)=C2F)CN1C(=O)[C@@H1]3C[C@@H1](F)C(=O)N3C CC(=O)NC1=CC=C(N)C(C(=O)N[C@@H1](C)[C@H1]2CN(C(=O)[C@@]3(F)C[C@@H1]3C)CCO2)=C1 CN(C(=O)C12CCC(CF)(CC1)CC2)C3CN(C(=O)C[C@@]4(C)C[C@@]4(F)Cl)C3 CC(C)N1C=NN=C1CC(=O)N[C@]23CCN(C(=O)[C@@]45CCC[C@@H1](CO4)C5)C[C@H1]2C3 CC=1C=C(C(=O)N[C@H1](CO)[C@H1](C)NC(=O)C(C)(C)C2=CSC=N2)N(C)N=1 CC(C)(C)C#CC(=O)NC1(CCC(=O)N[C@@H1]2CO[C@H1](C(F)F)C2)CCC1 CCC1=NC(C(=O)N2C[C@H1](F)[C@H1](NC(=O)CN3C[C@H1]4C[C@@H1]4C3)C2)=C5C=CC=CN15 CC(C)(CO)C(=O)N1CC[C@H1]2[C@@H1](C1)CN2C(=O)C3=CC=C(F)C(Br)=C3 CCCC=C[C@H1](O)C(=O)N[C@H1]1CCN(C(=O)[C@H1]2CC[C@@H1](N(C)C)CC2)C13CC3 CC[C@@H1](CN(CC)C(=O)CC=1C=COC=1C)NC(=O)[C@H1]2CC[C@@](C)(C)OC2 CCOC[C@H1](NC(=O)CC/C=C/C(C)C)C(=O)N[C@H1](C)C1=CC=CN=C1 CC[C@@H1](C)CCC(=O)N1C[C@H1](C)[C@@H1]1C(=O)N2CC(C(C)(C)C)C2 CS[C@@H1](C(=O)N[C@H1]1CN(C(=O)C(C)(C)N2CCCC2)C[C@H1]1C)C3=CC=CC(Cl)=C3 C=CCOCCNC(=NCC[C@@]1(O)CCOC1)NCC2=CC(C(F)(F)F)=CO2 CC(C)[C@H1](O)[C@@H1](C)C(=O)NCC(C)(C)CNC(=O)C1=CC(S(C)(=O)=O)=CS1 COC(=O)[C@H1]1CC[C@H1](C(=O)N2CC([C@H1](C)NC(=O)C3=CC=CC=C3C)C2)C1 CC[C@H1]1CN(C(=O)C2=CCCOC2)CC[C@H1]1CNC(=O)C3(C)CCC3 CC=1SC(O)=NC=1C(=O)N2CCC[C@]3(CNC(=O)C4(Cl)CC4)CCC[C@H1]23 CN1N=C(I)C=C1[C@H1]2CCCN2C(=O)NC[C@@H1](CO)CC3=CC=CO3 NC1=CC=NC(C(=O)N2C[C@@H1](C3CC3)[C@@H1]2C4CCN(C(=O)C5(F)CC5)CC4)=C1 CCC=1C=C(C(=O)NCCNC(=O)[C@H1]2CCO[C@H1]2C)SC=1C CCSCC(=O)N[C@@H1]1COCC[C@@H1]1NC(=O)C(C)(C)[C@@H1]2CCCO2 CO[C@@H1]1C[C@H1]1C(=O)N2CCO[C@@H1](CCNC(=O)C3=COC=N3)C2 CN(C(=O)CCOCCCNC(=O)C1=CC=2OC=CC=2S1)C3CSC3 COC[C@]1(C)C[C@@H1](N)CN1CC(=O)NCC2=CC=C(C(C)C)C=C2 COC[C@@](C)(O)C(=O)N[C@@H1]1CN(C(=O)C2=CC=C(OCC(F)(F)F)O2)C[C@H1]1C C=CCC(CC=C)NC(=O)C[C@@H1]1CN(C(=O)C=2SC=NC=2CC)CCO1 O=C(COC1COC1)N[C@@H1]2CCN(C(=O)CC3=CC=CN=C3)C24CCCC4 C[C@H1](CN=C1C=C[NH1]C=C1S(=O)(=O)NC[C@@](C)(O)C2CCC2)C3=CC=NC=C3 C#CC1=CC(Br)=CC(F)=C1NC(=O)N2CCC[C@@H1](N3C=NC4=CC=CC=C43)C2 CN(C)C(=O)C#CC(=O)NC[C@]12C[C@@H1]1CN(C(=O)CC3=CC=C(O)C(Cl)=C3)C2 COC1=CC=C(CCC(=O)NC2(CO)CN(C3=NC=NC4=C3C=C(I)N4C)C2)C=N1 CCO[C@@H1]1[C@@H1](C)[C@@H1]1C(=O)N2CC[C@H1](NC(=O)CCC3=NC=CS3)C2(C)C COC1(C(=O)N2C[C@@H1](O)[C@H1](NC(=O)[C@H1]3C[C@H1]3F)C2)CC1 C[C@@]1(C(=O)NC2CCC3(CC2)CC(NC(=O)CC=4C=N[NH1]C=4)C3)CCC(F)(F)C1 CC1=CC(C(=O)CCC(=O)N(C)[C@@H1]2CCCC[C@@H1]2NC(=O)C(C)(C)C3CC3)=C(C)S1 [N-1]=[N+1]=NC1=CC=CC(C(=O)N2CC[C@@H1]2CNC(=O)C3(S(N)(=O)=O)CCC3)=C1 O=C(N=C1C=C[NH1]C(C2CCC2)=C1)NC[C@H1](O)C3=CC=C(I)C=C3 CN(C)CCOCC(=O)NC(C)(C)CCC(=O)N1CC[C@](C)(N(C)C)C1 COCCN1C=CC(C(=O)N2C[C@H1]3C[C@@]3(NC(=O)[C@H1](C)C4=CC=CN=C4)C2)=N1 COC(=O)CCCCC(=O)N1CCC[C@@H1]2[C@H1]1CCN2CC3=CC=C(C(=O)O)C=C3 CN=C1C=CC(C(=O)N[C@@H1]2CCN(C(=O)CCCCSC)CC2(C)C)=C[NH1]1 CN(C)CC1(CNC(=O)[C@@H1]2C[C@@H1]3C[C@@H1]3N2C(=O)C(C)(C)CF)CC1 O=C(N[C@H1]1C[C@H1](O)CN(C(=O)CCCC2CCCCC2)C1)C3=CN=C(O)S3 CC=1N=NSC=1[C@H1](C)N=C2C=C[NH1]C=C2S(=O)(=O)NCCC[C@H1](C)CO C[C@H1]1CN([C@@H1](C(=O)NCC(F)F)CC23CC(C(C)(C)C)CC(C2)C3)C1(C)C COC1=CC=C(O[C@H1](C)C(=O)N[C@H1]2CN(C(=O)CCCC(F)(F)F)CC2(C)C)C=C1 C[C@H1]1C[C@@H1](NC(=O)CC2CCSCC2)CCN1C(=O)C=3C=C(F)N(C)N=3 CCC=1OC=CC=1C(=O)N2C[C@H1]3CC[C@H1]2[C@H1](CNC(=O)C45COC(CF)(C4)C5)C3 CCN1N=NC2=C1CC[C@@H1](C(=O)N3CCN(C(=O)[C@H1]4CC=CCO4)CC3)C2 O=C([C@@H1]1CCOC1)N2CCN[C@@H1](C(=O)N3CC[C@]4(C3)CC4(F)F)C2 COC[C@@]1(NC(=O)[C@@H1]2CCSC2)CCN(C(=O)C3(C4(O)CCOCC4)CC3)C1 CN1N=NC=C1C(=O)N2CCC[C@@H1](C(=O)N3CC[C@@H1]3C=4C=NN(C)C=4)CC2 CC1=CC(C[C@@H1](C)NC(=O)CCN(CC2CC2)C(=O)CN3CCC[C@@H1]3C)=N[NH1]1 C#CCC(C)(C)C(=O)NCC1CC(NC(=O)C=2OC=NC=2CCC)C1 C[C@H1](CC(=O)N(C)C1(CC(=O)N(C)CC2=CC=CC=N2)CC1)[C@H1]3CCCO3 CN1CC(=O)N(CC(=O)N2CCN(C(=O)[C@@H1]3CCN(C)C3=O)C[C@H1]2CF)C1=O CC(=O)N1CCC2=CC(C(=O)NC(=O)C3=CC(C)=NC4=C(Br)C=NC=C34)=CC=C21 COCC[C@@H1](CNC(=O)C1=CC(C)=NS1)NC(=O)C2=NC=CC3=NC=NC=C23 CN(C)C(=O)C(=O)N1C[C@@H1]2C[C@H1]1C[C@H1](NC(=O)C3=CC4=CC(F)=CC=C4OC3)C2 CC(C)OC[C@H1](C)NC(=O)CC[C@]1(C)CCCN1C(=O)C2CCOCC2 CC[C@@H1](C)CC(=O)N1C[C@@H1](O)[C@H1](N(CC2=CC=CC=C2)C(=O)CS(=O)(=O)CCO)C1 C=CC[C@H1]1CCN(C(=O)CN2C=C(CNC(=O)CN3C(=O)CCC3=O)N=N2)C1 CN(C)[C@H1]1C[C@@H1](C(=O)N(CCNC(=O)[C@H1]2C[C@]2(C)C(F)F)C3CCCC3)C1 C=C[C@@H1](O)C(=O)NCC1=CC(O)=NC(CNC(=O)CCC2=CC=CC=C2)=N1 CN1C=NC(CCCNC(=O)[C@H1]2CCN(C(=O)C3=CC=C([N+1](=O)[O-1])[NH1]3)O2)=N1 C#CC1(F)CN(C(=O)[C@H1]2CCOCCN2C(=O)[C@@H1](O)C3=CCCCC3)C1 CN(C)C(=O)CCC(=O)NC[C@H1]1C[C@H1]1C(=O)N[C@H1]2CCC=3N=N[NH1]C=3C2 CCN(CCNC(=O)C=1C=C2N=CC(Br)=CN2N=1)C(=O)CCCC(=O)OC O=C(N[C@@H1]1C[C@@H1]2C[C@H1]1N(C(=O)CC3=CC(O)=NC(O)=N3)C2)[C@H1]4CCCO4 CC(=O)NC1=CC=CC(CC(=O)NC[C@H1]2C[C@H1](C)N(C(=O)CC(F)(F)F)C2)=C1 CO[C@H1](C(=O)N(C)[C@@H1](C)CNC(=O)C1=CN=C(CC(C)(C)C)S1)C2=CC=CN=C2 CN(CCC(=O)NCCC#CCO)C(=O)CCCN1CCCC1 C[C@@H1]1CCCN1CC(=O)N2CCN(C(=O)CCC3OCCO3)[C@H1]4COC[C@H1]42 COCC[C@@H1](C)C(=O)NC1CC2(CC(NC(=O)C=3SC=CC=3C#N)C2)C1 C[C@H1](C(=O)N1CC[C@H1]([C@@H1]2CCCN(C(=O)C3=CCSC3)C2)C1)C4=CC=CN=C4 CC1=C[NH1]C=CC1=NC(=O)[C@@H1]2[C@@H1]3C[C@@H1]2N(C(=O)C4=CC=C(C=5C=N[NH1]C=5)C=C4)C3 CC[C@@H1]1CCO[C@@H1]1C(=O)N[C@H1]2CC[C@H1]2CNC(=O)CSC=3C=NN(C)C=3 CN1N=CC=C1C(=O)N2[C@H1]3C[C@@H1](C[C@@H1]3F)[C@H1]2C(=O)N[C@H1](CO)C4=CC=CC=C4 CC=1C=CSC=1C(=O)N2C[C@@H1](NC(=O)C3(CC4CCC4)CC3)[C@H1](C5CC5)C2 CCC1=NC=CC=C1C(=O)N2[C@H1]3CC[C@@H1]2C[C@@H1]3NC(=O)C4=C(C)N=C(C)N=C4C CC(C)[C@@H1](O)C(=O)N[C@H1](C)[C@H1]1CCCN1C(=O)C2CN(C)C2 N#C[C@@H1]1CC12CCN(C3=NC4=C(C(=NCC5(CO)CC=CC5)[NH1]3)CCCCC4C)C2 CSCCC(=O)NC[C@]12CCCC[C@@H1]1N(C(=O)CNC(=O)CC(F)(F)F)CC2 CSCC[C@@H1](O)C(=O)N1CC2(CNC(=O)C=CC3=CC=C(C)O3)CCC1CC2 CC[C@H1](CC(=O)NC[C@@](C)(O)CNC(=O)C1(C2=CC=C(C)C=C2F)CC1)C(C)C CC[C@](C)(CNC(=O)C1(C)C2CC3CC(C2)CC1C3)NC(=O)C=4C=NSN=4 O=C(NC1=NC=C(I)N=C1Cl)C2(OCCCC3=CC=CC=C3)CC2 CC[C@@H1](CN(CC)C(=O)[C@H1](F)CC1CC1)NC(=O)C(F)=C2CCCCC2 C[C@@H1](NC(=O)C12CCN(CC1)C2)C(=O)N3CC4=CC=C(C#N)C=C4C3 CCOC(=O)N1CCC(C(=O)N[C@@H1]2CCC[C@@H1]2CNC(=O)C3=CC(C)=NO3)CC1 CCNC(=O)NC(C)(C)C(=O)N[C@H1]1CN(C(=O)[C@]2(C)CC2(C)C)CC[C@H1]1F CCCCN1CCOC[C@@H1]1C(=O)N2C[C@@H1](C)N(C(=O)C=3OC=NC=3CC)C[C@@H1]2C CCOCC(=O)NC[C@@H1]1N(C(=O)C2=CC=NN2[C@H1](C)CC)CCCC1(C)C CC1=CC=C(CCC(=O)N2CC[C@@H1](CNC(=O)C3=CC=CC(F)=C3I)C2)C=C1 CC(C)[C@H1](O)C(=O)N[C@@]12CCCCC[C@@H1]1N(C(=O)C=3N=CN4C=CC=CC=34)CC2 CO[C@@H1]1C[C@H1]1C(=O)N[C@H1](C)C2(O)CN(C(=O)COC3=CC=C(Cl)N=C3)C2 CCOC(=O)[C@@H1]1CN(C(=O)[C@H1]2CCC[C@@H1]2NCC3=CC=NC(Cl)=C3)CCO1 C=CC(C)(C)C(=O)N[C@@H1]1CS(=O)(=O)C[C@H1]1NC(=O)CC=2N=CN3C=2COCC3 O=C(CCOCC1=CC=CC=C1)NC[C@H1]2C[C@](F)(CNC(=O)[C@H1]3C[C@H1](O)C3)C2 C[C@@H1]1CC[C@@H1](C(=O)N2CCC(C)(CCNC(=O)C3=CC=CC4=C[NH1]N=C34)CC2)O1 C[C@@H1](CS(C)(=O)=O)NC(=O)[C@H1]1C[C@@H1](CNC(=O)C2CC3(C2)CC34CC4)C1 CC(=O)N1CCCC[C@H1]1C(=O)NCCCCCCN(C)C(=O)C2(C)CC2 COC(=O)[C@H1](C)C(=O)N[C@@H1]1COCCN(C(=O)C2=NC=C(Br)C=C2C)C1 NC1=CC=CC(C(=O)N2CC[C@H1]3CC[C@@H1](C2)N3C(=O)[C@@H1]4CCCC5=N[NH1]C=C54)=N1 CN(C)C1=NC(Cl)=C(C(=O)N[C@]2(CNC(=O)CNS(=O)(=O)N(C)C)CCOC2)S1 CC[C@H1](NC(=O)C1(O)CCN([C@H1]2CCNC(C)(C)C2)CC1)C3=CC=C(F)C=C3F CONC(=O)C(=O)NC[C@H1](C(=O)N1CC(C=2C=CON=2)C1)C(C)(C)C COC[C@@H1]1C[C@H1]1C(=O)N(C)C2CCN(C(=O)CCCSC3=CC=CC=C3)CC2 CNC1=CC=C(N2C=C([C@@H1]3[C@H1]4CN(C(=O)[C@H1]5CCCCO5)C[C@H1]43)N=N2)C=C1 CS[C@H1](C)C(=O)N[C@]1(C)C[C@H1](NC(=O)C2=CN=NC(C)=C2C)C1 O=C(NCC1(NC(=O)[C@@H1](O)C2CCCC2)CCC1)[C@H1](F)C3CC3 C[C@H1]1CN(C(=O)C2=CC=C(F)N=C2)C[C@H1]1CNC(=O)CCCN=[N+1]=[N-1] CC1=CC=C(O[C@@H1](C)C(=O)N2CC[C@H1](S(C)(=O)=O)C2(C)C)C(C)=C1 CNS(=O)(=O)C1=CC=C(CC(=O)N[C@H1]C2[C@@H1]3CN(C(=O)C(F)F)C[C@]3(C)C2)S1 CC1=CN=CN=C1C(=O)N[C@H1](C)CCN(C)C(=O)/C=C/C2=CSC3=CC=CC=C23 CN(CCC(C)(C)NC(=O)C1=CC=NN=C1)C(=O)C2=C[C@H1]3CCC[C@@H1]23 N#CC1=CC=C2[NH1]N=C(CNC3CC[C@H1](N=CN=C(N4)C=CC(Br)=CC4=O)C3)C2=C1 CN(C(=O)[C@H1]1C[C@H1]2O[C@@H1]1[C@@H1]3C[C@H1]23)[C@@H1]4CN(C(=O)C5=CC([N+1](=O)[O-1])=NN5C)C[C@H1]4O CCCOC1=CC=C(CN2CCC[C@@H1]2CNC(=O)C3=N[NH1]C(C)=C3C)C=C1OC COCC=CC(=O)N(C)[C@@H1]1CCN(C(=O)C2=NC3=CC=CN=C3S2)C[C@H1]1C C[C@@H1](CNC(=O)CC1=CN=CN=C1O)CN(C)C(=O)C2=CC(N(C)C)=CC=C2N CC(=O)N(C)CCC(=O)N1CC(CO)(NC(=O)C2=CC(I)=CN=C2Cl)C1 CCC[C@@H1](CC)CC(=O)N1C[C@@H1]2C[C@@H1](NC(=O)C=CC3=NN=C(C(C)C)O3)[C@H1]1C2 CNC(=O)[C@@H1]1C=C[C@H1](NC2=CC=C(S(=O)(=O)N[C@H1]3CCC4(CCC4)C3)C=N2)C1 COCC1=NC(C(=O)N[C@]2(C)CCN(C(=O)C3=CC=C4C(=C3)CNC4=O)C2)=CS1 CSC=CC(=O)N1CCC2(CCCN2C(=O)[C@@H1]3CCC[C@@H1]3SC)CC1 O=C([C@H1](O)C=1C=CSC=1)N2CC[C@H1]3CC[C@@H1](C2)N3C4=NC=C(I)C=N4 CCC(F)(F)CC(=O)N[C@@H1]1CN(C(=O)[C@@H1](C)NC(=O)CN2C=NN=N2)C[C@H1]1O O=C(COCCC1=CC=CC(F)=C1)N[C@H1]2C[C@@H1](CNC(=O)[C@@H1]3C[C@H1]3CF)C2 CCC1=C[NH1]N=C1C(=O)NC2([C@@H1]3CCCN3C(=O)C4=NN=CS4)CC2 CCCC=C(CC)C(=O)NCC1(C(=O)N2CC[S@@](=O)[C@H1](C)C2)CC1 CC(C)CSCC(=O)N[C@H1]1CCC[C@]1(C)CNC(=O)C2=CN=CN(C)C2=O CCC1=CC(F)=CC=C1C(=O)N2CC(O)([C@H1]3CCCN3C(=O)C4=CC(F)=C[NH1]4)C2 CC1=CC=CC(C(=O)N2CCOC[C@@H1]2C(=O)N(CCO)C3CCC3)=C1C#N CC[C@H1](CCO)NC(=O)CC1(N(C)C(=O)C2=CC=C(C3CC3)C=C2)CC1 COCC=1C=CSC=1C(=O)N2CCO[C@H1]([C@H1](C)NC(=O)C=3C(Cl)=N[NH1]C=3C)C2 C=C[C@@H1](COC)NC(=O)[C@@H1]1CC2(CCC2)CN1C(=O)CCC(C)(C)C#N C=C=CCCC(=O)NC1(CC)CN(C(=O)[C@]23CCC[C@H1]2C3)C1 CC1=NOC=C1C(=O)NC[C@@]2(O)CCN(C(=O)C3=CN=C4C=NC=CC4=C3)C2 CCC=CC=CC(=O)N1CC2(C[C@H1](NC(=O)[C@H1]3C=CC(=O)N=N3)C(C)(C)C2)C1 CO[C@@H1]1COC[C@H1]1N2C=C(C(=O)NC[C@@H1](O)CN(C)C(=O)C3CC(F)C3)N=N2 CNC(=O)CCN1C=C(C2(O)CN(C(=O)[C@H1]3CCC[C@@H1]3S(C)(=O)=O)C2)N=N1 CC1=CC(C(=O)N2C[C@H1]3C[C@@H1]2[C@@H1]3C(=O)NC4=CC=NC=N4)=CN=C1C CC=1SC=CC=1C(=O)NC[C@H1](CO)CNC(=O)[C@@H1](C)OC2=CC=C(C#N)C=C2 CCOCCOCCC(=O)N[C@@H1]1CCN(C(=O)C(C)(C)CC(C)C)C[C@@H1]1F C[C@@H1](O)C1CCC(NC(=O)[C@@H1]2C[C@@H1]3C[C@@H1]3N2C(=O)C/C=C/C4=CC=CC=C4)CC1 CCC1=NOC(C(=O)N(C)C[C@H1](O)CNC(=O)C=C2CCN(C)C2)=C1C O=C(CN1C=C(C2CC2)C=N1)NC3CCC(CNC(=O)C4=CC=NC(F)=C4F)CC3 COC1=C(F)C=CC(C(=O)N[C@@H1]2CCCN(C(=O)C3=CC=CO3)C2)=C1F O=C(N[C@H1]1C=CCN(C(=O)C2=CC=C(Br)O2)C1)C3=NC=NC(C(F)(F)F)=C3F CCCC(=O)N[C@@H1](CNC(=O)CCC1=CC=C2C=NN(C)C2=C1)CC(C)C CCC=1[NH1]N=C(C(=O)N[C@@](C)(CNC(=O)CC2CC3(CCC3)C2)C(C)C)C=1C CN(C[C@H1](O)CNC(=O)C[C@H1]1CNC(=O)C1)C(=O)C2=C(Cl)C=CC3=CC=CN=C23 CC1=CC(Cl)=C(C(=O)N2CCC([C@@H1](C)NC(=O)C=3N=N[NH1]C=3Cl)CC2)S1 N#C[C@@H1]1CCC2(CCOCC2)[C@H1]1NCC=3C=C(C4CCC4)ON=3 COC[C@@](C)(O)CC(=O)NC[C@@H1](F)CNC(=O)C1=CC=[N+1]([O-1])C=C1 CC1(C)C=C(C(=O)NCCCOCCCNC(=O)CN(C)C2=NC=CC=N2)C1 CC1(C)CC2(CC(C(=O)NC[C@H1](NC(=O)[C@@H1]3CCC(=O)C3)C4CCC4)C2)C1 C[C@@H1](C(=O)N1CC[C@]2(C=C(C(=O)N(C)CCCO)C2)C1)N3C=CC=N3 CN(C(=O)C1=CC=C(O)C=N1)[C@@H1]2CN(C(=O)CN3C(=O)CCC3=O)CC24CC4 C[C@@H1](CC(=O)N[C@@H1](CNC(=O)CC1=CC=CN=C1Cl)C2CC2)NC(N)=O CCOC(=O)C1=N[NH1]C2=C1CC[C@@H1](N[C@@H1](C)C=3C=CN(C4=CC=CC=C4)N=3)C2 CC(C)N(CCNC(=O)[C@@H1]1CCCCC(=O)N1)C(=O)CC23CC[C@@H1](C2)C3 O=C(N[C@@H1]1CCN(C(=O)[C@H1]2C[C@@H1](C(F)(F)F)C2)C1)C3=CC(Cl)=C[NH1]3 CC1=CC=NC=C1CN2CCCO[C@H1](CNC(=O)C[C@H1](C)C=3C(C)=NOC=3C)C2 C[C@@H1](C(=O)N1C[C@H1]2CC[C@@](C(=O)NC3CC(C4CCCC4)C3)(C2)C1)N(C)C COC1=CC=C(C(=O)N[C@@H1]2[C@H1]3C[C@@H1]4[C@H1]2[C@@H1]4[C@@H1]3C(=O)NCCCN5C=CN=C5)O1 CC[C@@H1](C#N)C(=O)N[C@@H1](CNC(=O)CN1CCC(CO)CC1)C2CCC2 O=C(N1CC[C@H1]2CN(C(=O)C3(C4(O)CCC4)CC3)C[C@H1]2C1)C=5C=COC=5Cl CCC1=N[NH1]C(=N[C@H1]2C[C@@H1](C)N(C(=O)C3=CC=NC(F)=C3)C2)S1 CC(=CC(=O)NC[C@H1](CO)CNC(=O)C(C)(C)N1C=NN=N1)C(C)C CC1=CC(C(=O)N[C@@H1]2CC[C@@H1]2NC(=O)C3=CC=NN=C3)=C(S(=O)(=O)N(C)C)C=N1 CC[C@H1]1C[C@@H1](OC)CN(S(=O)(=O)C2=CSC3=CC=CC=C23)C1 CCC1=C(F)C=CC=C1C(=O)N2C[C@@H1](CNC(=O)CN3C=C(C)C=N3)CC[C@H1]2C COC[C@H1](CC(C)C)C(=O)NC[C@@H1]1C[C@H1](OC)CN1C(=O)C2=CC=CC(O)=C2Cl COC1=CSC(C(=O)N[C@@H1](C)[C@@H1]2CCCN2C(=O)C3CC(N4C=CC=N4)C3)=C1 C[C@@](O)(CCNC(=O)C#CCNC(=O)C1(C(F)(F)F)CC1)C2CC2 C[C@@H1](NC(=O)NC[C@@H1]1CC(C2CC2)=NO1)C3=CC=CC=C3C(F)(F)F CCCC1=CC=C(C2=CC=C(NC(=O)[C@@H1]3CCN3CC)S2)C=C1 CC1(NC(=O)[C@@H1]2C[C@]2(C)Br)CCN(C(=O)C3=CC4=CC=C(F)C=C4[NH1]3)CC1 CC[C@@H1](NC(=O)C1=CC=CC([C@@H1]2CCCN(C)C2)=C1)C(C)(C)O CO[C@H1](C(=O)NC[C@H1]1CN(C(=O)[C@@H1]2CCC(=O)N(C)C2)CCO1)C3CCCC3 CCN1CC[C@H1]1C(=O)NC[C@]23CC[C@H1]2CN(C(=O)C4=NN=CS4)C3 C[C@@H1](SC1=CC=CC=N1)C(=O)N[C@]2(C)C[C@@H1](NC(=O)C3=CC([N+1](=O)[O-1])=C[NH1]3)C2 CO[C@]1(C(=O)N2CC(O)(CN(C)C(=O)CCOCC3=CC=CC=C3)C2)CCSC1 CC1=C(C(=O)NCC(C)(C)OCCNC(=O)[C@H1]2CC23CC(F)(F)C3)N=NN1C O=C(CCC=1N=C[NH1]N=1)N[C@@H1]2C[C@@H1]2CNC(=O)[C@H1]3COC4=CC(Cl)=CC=C4O3 CCCCCCO[C@@H1](C)C(=O)N(C)C[C@@H1](C)NC(=O)C(C)(C)N(C)C C#CCOCCNC(=O)C=1[NH1]C=CC=1CNC(=O)[C@@]2(C)CCCN2C CC(C(=O)N1CC[C@@](CNC(=O)C2=NON=C2N)(C3CC3)C1)=C4CCC4 CC1=NC(SCCC(=O)NC2=CC=C3OC(C(F)(F)F)=CC(=O)C3=C2)=N[NH1]1 CCOC1=NC(C(=O)N[C@@H1]2CC[C@@H1](CNC(=O)C3=NC=NC(O)=C3Cl)C2)=CO1 CN1CC[C@]2(CCCN(C(=O)C(=O)NCCC[C@@H1](O)C(=O)OC)C2)C1 C#CCCC(=O)N(CCCNC(=O)[C@H1]1CC[C@H1]2CCC(=O)N21)CC3=CC=CC=C3 CC1=CC(NC[C@@H1]2C[C@@]3(CCN3C(=O)C4=CN(C5CCC5)N=C4C)CO2)=NC=N1 CN(C(=O)[C@@H1]1C[C@H1]1F)[C@H1]2CCCC[C@@H1]2N(C)C(=O)C3=CN4C=CN(C)C(=O)C4=N3 O=C(N[C@@H1]1CC[C@@H1]2CN(C(=O)C=3OC=CC=3Br)C[C@@H1]2C1)C4=CN(C(C)(C)C)N=N4 COC1=CC=C(C(=O)N2CCCN(C(=O)[C@@H1]3C[C@H1]3CF)CC2)C=C1C C#CC1(C(=O)N2C[C@H1]3CCO[C@@]3(CNC(=O)CC(=O)OCC)C2)CC(=O)C1 C=CC[C@H1](CNC(=O)C1=CC=CN=C1NC)NC(=O)C2=CC(=NC)[NH1]C=C2Br COC1=CN=C(F)C(C(=O)N2CC[C@@H1](CNC(=O)[C@@H1](CC(C)C)C(C)C)C2)=C1 CC[C@@H1]1CCCN1C(=O)C(=O)NC[C@@H1]2CCCN(C(=O)C3(SC)CC3)C2 C[C@@H1](C(=O)OC(C)(C)C)N(C)S(=O)(=O)N1CCN(C2=CC=CC=C2[N+1](=O)[O-1])CC1 C[C@H1](CC1=CC=NC=C1)C(=O)NC2CC3(C2)C[C@@H1]3NC(=O)COCC4CC4 CN(C[C@@H1]1CCN(C(=O)[C@H1]2CC23CCCC3)C1)C(=O)C4=CN=C(O)N(C)C4=O COC1=COC(C(=O)N[C@H1]2CCO[C@H1](CNC(=O)C3CN(CC(C)C)C3)C2)=CC1=O CCOC(CC(=O)N1CCN(CC2=CC(OC)=CC=C2F)C[C@@H1]1CC#N)OCC CCO[C@@H1]1CCCN(C2=NN=C(COC)N2CC3(CC3)C4=CC=CC=C4)C1 CC[C@H1](NC(=O)C(=O)NC1=CC=C(C)C(O[C@H1]2CCOC2)=C1)C3CCCCCC3 C[C@@H1](CCC(=O)N[C@H1]1C[C@H1](NC(=O)C2=CC=CC([S@@](C)=O)=C2)C1)S(C)(=O)=O CO[C@H1](C(=O)N[C@]1(C(=O)N2CCC([C@H1](C)OC)CC2)CCSC1)C(C)C CC1=CC(C(=O)C(=O)N2CC(C)(C)C(NC(=O)[C@@H1](C)CO)C(C)(C)C2)=CC=C1F C[C@@H1](NS(C)(=O)=O)C(=O)N1CC[C@@H1](CNC2=NC=NC(O)=C2Br)C1 CC1=CC=CC([C@@H1](O)C(=O)NCC[C@H1](C)NC(=O)C=2[NH1]N=NC=2C3CC3)=C1F CC1=NN2C(=C1CNC(=O)[C@@H1]3[C@@H1](C)[C@H1]3C)CN(C(=O)CC4=CC=C(O)N=C4)CC2 CCC1=CC=C(C(=O)N(CC)[C@@H1]2CCCN(C(=O)C3=C(F)C=CC=C3F)C2)C=C1 C[C@H1]1C[C@@H1](NC(=O)CCN2CCCC3=CC=CC=C32)CCN1C(=O)[C@@H1]4CCOC4 CCN(C(=O)[C@@H1]1O[C@H1]2CC[C@H1]1C2)[C@@H1]3CCN(C(=O)C4=CC=NC=5[NH1]N=CC4=5)C3 CN(CCCNC(=O)C1=C(F)C=CC(Cl)=C1F)C(=O)CCSC2=NN=NN2C N=C1[NH1]C2=CC(C(=O)N[C@@H1]3CCN(C(=O)[C@]45CCCC[C@H1]4C5)C3)=CC=C2S1 O=C(N[C@H1]1C[C@@H1](CO)N(C(=O)C2CCS(=O)(=O)CC2)C1)C3[C@H1]4CCCCCC[C@H1]34 CCS[C@H1](C)C(=O)N[C@H1]1CN(C(=O)CC2(O)CCN(C)CC2)CC[C@H1]1C(F)(F)F CC(C)C#CC(=O)NC[C@@H1]1COCCN(C(=O)C[C@@H1]2CC[C@H1]3C[C@H1]23)C1 CN(C)CC1CC(NC(=O)C2=CC=CC(NC(=O)C3=CC=CC(O)=N3)=C2)C1 C=CC[C@@H1](CC)C(=O)NC[C@H1](CCNC(=O)C=1C(C)=NOC=1C)OC CC1=CC=C2[NH1]N=C(CNCC3(C(=O)NC4=CC(C#N)=C(F)C=C4C)CC3)C2=C1 CC[C@@]1(C)CC[C@H1](C(=O)NCCN(C)C(=O)C=CC(=O)N2CCOCC2)O1 CCCN(CCNC(=O)C1=CC=CN(C)C1=O)C(=O)[C@H1]2C[C@@H1]2[N+1](=O)[O-1] CCOC(=O)[C@H1](CC)NC(=O)[C@@]1(C)C[C@@H1](O)CN1C(=O)CC2=CC=CC(C)=C2 C#CC=1C=NN(CC(=O)NC[C@H1](CCCC)NC(=O)C2=CSC(Cl)=N2)C=1 CC(=O)OCCN1CCC2(CC1)C[C@H1](C)N(C(=O)C=3C=CN4C=NC(C)=C4C=3)C2 CC1(C#N)CCN(C(=O)C2=CC[C@H1]3CC[C@H1]2N3C(=O)[C@H1]4C[C@H1]4C(F)F)CC1 C[C@H1]1[C@H1]2CC[C@@H1](C2)[C@@H1]1C(=O)NC3(C(=O)N[C@@H1]4CCCC[C@@H1]4CO)CSC3 COCCN1C=C(C(=O)N[C@H1](C)CN(C)C(=O)C[C@@H1]2CCCOCC2)N=N1 CC1=CC(Cl)=CC=C1CC(=O)N2CC[C@@H1](NC(=O)C3(C)SCCCS3)[C@H1](C)C2 COCC[C@@H1](CNC(=O)[C@@H1](C)CO)NC(=O)CS(=O)(=O)C1=CC=C(Cl)C=C1 CN(CCCN=C1C=CC2=C([NH1]1)CCCC2=O)C(=O)C=3C=CC(=O)OC=3 C=CCSCC(=O)NC1CN(C(=O)C2([C@H1]3CCCCO3)CCC2)C1 CC(C)(C)C(=O)N1CCN(C(=O)C2=CC=CC3=C2CCC3)[C@H1](C4CCC4)C1 CC(C)(C)OC(=O)N[C@H1]1C[C@@](F)(CNC(=O)C=2SC=C3C=2OCCO3)C1 CCC1CCC(N2CCCCC3(CCC3)C2)(C4=NN=NN4[C@@H1](C)CC)CC1 O=S(=O)(NCC1=CC=C(F)N=C1N(C)C)N2CCC[C@H1]2[C@@H1]3CCCOC3 C[C@@H1](CCC(C)(C)C)C(=O)N[C@@H1]1CCC[C@H1](NC(=O)C2(CC3CCC3)CC2)C1 CN1CCC(CN(C)C2=NC(=NCC3=CN=NS3)[NH1]C4=C(F)C=CC=C24)CC1 CN1C=CC=C1C2=CSC(C(=O)NC3CCC(C4=CC=C(F)C=C4)CC3)=C2 FC1(CN=C2[NH1]C3=C(C(=NC4CC5(CCCO5)C4)[NH1]2)COC3)CCC1 CON(C)C(=O)[C@H1](C)N[C@](C)(CCOCCBr)C1=NN=NN1C2CCC2 CC1=NC=C(CCC(=O)N(C)CCCCNC(=O)[C@H1](O)C2CCOCC2)O1 C[C@@H1]1C[C@@H1](NC(=O)[C@H1]2C[C@H1](C#N)C2)CN(C(=O)[C@@H1]3C=CCC3)C1 CO[C@H1]1[C@H1](O)C[C@H1]1NC(=O)[C@H1]2CCCN(C(=O)C[C@@H1](C)C3CC3)[C@H1]2C CN(CC1CCCCCC1)S(=O)(=O)CCNC(=O)[C@@]23CCC[C@@H1](C2)OC3 CCNC(=O)CCC(=O)N[C@@H1]1C[C@H1]2C[C@@H1](C1)N(C(=O)C=3C=CN(CCO)C=3C)C2 O=C(C1=CC=CS1)N2CCC3(CCCN3C(=O)CCC4=NN=CS4)CC2 CC=1C=C(C2=CN=CC=C2C(=O)NC3=CSC(Br)=C3)N(C)N=1 C[C@@]1(C(=O)NCCOC2CCN(C(=O)/C=C/COC(C)(C)C)CC2)CC=CCC1 C[C@@H1]1O[C@H1](C)C[C@@H1]1[C@@H1](NCC2=NC=CN2CC(F)(F)F)C3=NN=NN3CC(F)F CS(=O)(=O)CCCC(=O)NCC[C@H1]1CC[C@@H1](NC(=O)[C@H1]2CC3(CCC3)CCO2)C1 CCC=1N=NSC=1C(=O)N2CCO[C@H1]([C@@H1](C)N=C3C=C(C)N=C(SC)[NH1]3)C2 O=C(NC[C@H1]1CN(C(=O)C2=CC=C(CO)C=N2)CCO1)[C@H1]3CN4CCC3CC4 CCOC(=O)C[C@@H1](NC(=O)C1=NC(C)=NN1C)C2=CC=C(F)C=C2 CCCC[C@H1](O)[C@H1](C)C(=O)NCC=1N=COC=1C2CN(C(=O)C(=O)NOC)C2 CN(CCNC(=O)[C@H1]1C[C@H1](NC(=O)C2(N3C=CC=N3)CC2)CC1(C)C)C4CC4 C=C[C@H1](CC)CC(=O)N1CC[C@@](CC=C)(C(=O)NC2CC(N3C=NC=N3)C2)C1 CC[C@H1](NC(=O)N[C@H1](CCC(C)C)C(C)(C)C)C1=CSC(C)=C1 CCCCCC[C@H1](F)C(=O)N[C@H1]1C=CCN(C(=O)CC=2SC(O)=NC=2O)C1 CO[C@H1](C(=O)NCC12CC(C1)[C@@H1](NC(=O)CSC(F)F)CO2)C3=CC=CN=C3 CCC1=NOC(C)=C1C(=O)N[C@H1]2CCN(C(=O)CC=3[NH1]C=NC=3C)CC(C)(C)C2 C=CC1(CNC(=O)CC[C@H1]2C[C@@H1](NC(=O)C=CCN3CCC3)C2)CCOCC1 CC1=CC=C(C)C(C(=O)NC[C@](C)(O)CNC(=O)C2(C=3C=C(C)ON=3)CC2)=N1 CC1=CN2C(CC(=O)N3CCCO[C@H1](CCNC(=O)C(F)(F)CO)C3)=CSC2=N1 CSCC1(CC(=O)OCC2=C(F)C=CC=C2F)CCC1 CC[C@@H1](SC)C(=O)NCC1=CC=C(CCNC(=O)CCC2=NC(O)=N[NH1]2)C=C1 CC1=NC=C(C(=O)N[C@H1](C)CCN(C)C(=O)C2CCN(CC(F)F)CC2)S1 CC(C)(C)OC(=O)N[C@H1]1CN(C(=O)NCC2=CN=N[NH1]2)CC3=CC=CC=C31 CCOC1(CCNC(=O)[C@H1](COCC)NC(=O)CC[C@H1](C)SC)CCC1 C[C@H1](C(=O)N[C@H1]1C=CCC[C@H1]1C(=O)N2C[C@H1]3[C@H1](C2)C3(C)C)C4=CN=CN=C4 CO[C@H1](CCSC)C(=O)N[C@@H1]1C[C@H1]1CNC(=O)CCC2=NN=C(C3CCCC3)O2 COC(=O)C1=C(C)OC=C1NC(=O)NCCCC2=NC(C(C)C)=N[NH1]2 COC(C)(C)C(=O)NC[C@H1]1COC(C)(C)CN1C(=O)C(=O)NCC(F)(F)F C[C@@H1](NC(=O)C1=CC=CC(C2=NC3=CC=CC=C3S2)=C1)C4(O)CCCC4 CCCN(C)CCC(=O)N[C@](C)(CNC(=O)C=1N=C(C2CC2)OC=1C)CC(C)C C#CCCCCC(=O)N1C[C@H1](NC(=O)[C@@H1]2[C@H1]3COC[C@H1]32)[C@H1](N4C=CN=N4)C1 CC1=NC2=CC=NN2C(C)=C1C(=O)NC[C@H1](C)C3CCN(C(=O)[C@H1]4CCO4)CC3 CC(=O)CCN=C(NCCC1CC=CC1)N2CC[C@H1](CC3CCCC3)C2 C[C@H1](C(=O)N1CCN(C)C[C@@H1]1C(=O)NCC2(O)CCN(C)CC2)N3CCCC3 COC[C@H1]1CN(C(=O)C2(C(C)C)CCC2)CCN1C(=O)[C@@H1]3C[C@@H1](C)CO3 CCC(CC)CCCC(=O)N(C)C[C@H1](C)N(C)C(=O)C[C@H1](C)CC(C)C CC1=NC=C(CC(=O)N2CC[C@](CO)(NC(=O)CSC3=CC=CC=C3)C2)S1 O=C(N[C@@H1]1C[C@H1]1[C@H1]2CCCN(C(=O)C3=CC=C(F)O3)C2)C4=CC(O)=NC=N4 O=C(NCC1CCN(C(=O)C2=CC=CC=C2CN3C=CN=C3)CC1)[C@H1]4CCCS4 O=C1CC[C@@H1](CCC(=O)N2CCC3(CCN(C(=O)C4=CCCOCC4)CC3)C2)C1 O=C(C1=CC=CC(O)=C1F)N2C[C@@H1]3CN(S(=O)(=O)C4=CC=C(Cl)C=C4Cl)[C@@H1]3C2 COC1=CC(OC)=C(N)C(C(=O)N(C)C[C@@H1](C)N(C)C(=O)C[C@@H1]2CCN(C)C2)=C1 CCCC1CC(C(=O)N2C[C@@H1]3CC[C@@H1](CNC(=O)C=CC=4SC=CC=4C)[C@H1]3C2)C1 CC1=NC=CN=C1C(=O)NC2(C(=O)N3C[C@H1](CO)CC[C@H1]3C)CCC2 C=C(C)COCC(=O)NC[C@@]1(O)CCCN(C(=O)[C@H1]2COCC3=CC=CC=C32)C1 O=C(CC(F)(F)Cl)N[C@H1]1CO[C@@]2(CCN(C(=O)CCCN3C=CC=C3)C2)C1 NC(=O)C1CCC(NC(=O)[C@H1]2CCCN2C(=O)C=CCF)CC1 C#CC1=CC=C([C@H1]2C[C@H1]2C(=O)NCC3=CN(C4=CC(Br)=CC=C4F)N=N3)C=C1 C[C@@H1]1C[C@H1](NC(=O)[C@H1]2[C@H1]3CC[C@@H1](C3)[C@H1]2C(F)(F)F)CCN1C(=O)/C=C/C(F)(F)F C[C@H1]1OCC[C@@]1(C)C(=O)N[C@@H1]2C[C@H1]3CC[C@H1]2N(C(=O)C4=NC=CN4C)C3 C=C=C(C)CC(=O)NCC[C@@H1]1CCN(C(=O)C(F)=CC2CC2)C1 CCCC[C@@H1](C)C(=O)N[C@@H1](C)C1(CNC(=O)CCC2=CN=CC=N2)CC1 COC(=O)CCCC(=O)N[C@H1]1CCC[C@H1](NC(=O)C[C@@H1]2C(=O)NN=C2C)C1 CSC1CC(C(=O)N2CC(C3CCN(C(=O)CCC(F)(F)F)CC3)C2)C1 O=C(NCC1[C@]2CC[C@@H1]2CN(C(=O)C3=CSC([N+1](=O)[O-1])=C3)C1)C4=CC=CC(F)=C4 O=C(N[C@H1]1C[C@@H1](F)CN(C(=O)CC2=NN=C(O)S2)C1)[C@H1]3CCN4C(O)=NN=C4C3 CO[C@H1]1C[C@@H1]2C[C@@H1](C(=O)NC(C)(C)CNC(=O)CCOC3=CC=CC(C)=C3)C[C@@H1]21 C[C@H1]1CN(C(=O)C2=CC(F)=CC=C2O)[C@H1]1C(=O)NC[C@@H1]3CC(F)(F)CO3 CCN(CCN(C)C)C(=O)COC1(C)CN(C(=O)CNC(=O)C2CC2)C1 O=C1C[C@H1]2C[C@@H1](C(=O)NCC3(C(=O)N[C@@H1]4CCC[C@@H1](C5CC5)C4)CCC3)[C@H1]1C2 CCCCN(CCCC)C(=O)[C@@H1](CC1CCCC1)NC(=O)C2=CN=C(CC)N=C2 CC1=CSC(C2=CC=CC(C(=O)N[C@@H1](C)[C@@H1]3CN(C(=O)CC4CC4)CCO3)=C2)=N1 O=C(NC1C[C@@H1]2CN(C(=O)C3=CC=C(Cl)S3)C[C@H1]2C1)C4C[C@H1]5CC[C@H1](C4)C5 CCN(CCNC(=O)[C@@]1(O)CCOC1)C(=O)C2=CC=CC(C#N)=C2Br COC1(C(=O)N[C@@H1](C)[C@@H1](NC(=O)COC2=CC=CC=C2)C3=CC=CC=C3)CC1 O=C1CN(CC(=O)N2CC3(CO[C@H1](CNC(=O)C4(C5CCC5)CC4)C3)C2)C(=O)N1 CN1N=CC=C1CCCNC(=O)[C@H1]2CCO[C@@H1]2CNC(=O)C3=CC=C(Cl)C=N3 O=C(N[C@H1]1C[C@@H1]1CNC(=O)C2=CC=C(C(F)F)C(Cl)=C2)C3=CC=4SC=NC=4[NH1]3 CSC=CC(=O)NC(C)(C)CNC(=O)C[C@H1](C)C(F)F FC1=CC=C2C=CC=NC2=C1CNC3=CC(=NC4=NC=CC=N4)[NH1]C(C(F)F)=N3 C#CC[C@H1](O)C(=O)N1CCN(C(=O)CSCC2=CC=NC=C2)[C@@H1](C3CC3)C1 CCC1CC([C@H1](NCCOCC2CC2)C3=NN=NN3CC)C1 CC[C@H1](OC)C(=O)N1C[C@@H1]2C[C@H1]3C[C@H1]2[C@@H1]1[C@@H1]3NC(=O)C4=CN=C5C(=C4)CCCO5 CN1CCN(C(=O)CC2=CCOCC2)C[C@@H1]1C(=O)NC3CCCCCCCC3 CC(C)(C(=O)N[C@@H1]1CCC[C@H1](CNC(=O)C2=CC=CC=N2)C1)C3=CC=CC=C3Cl CCN1C=CC(C(=O)N[C@]23CCC[C@@H1]2N(C(=O)C4=CC=CC=C4C)CCC3)=C1C CC[C@](C)(O)C(=O)NCCC1(NC(=O)C=2C=C(C)N([C@H1](C)C3CC3)N=2)CCC1 CN(C(=O)C1=CN=C([C@@H1]2CCCO2)S1)C3CCN(C4=CC=C([N+1](=O)[O-1])C=C4)CC3 CC(C)C1=CC=CC=C1N2C=C(CNCCC3=CC(O)=NC=C3Br)N=N2 CN(C(=O)CCC(F)F)[C@H1](CNC(=O)[C@@H1]1CCC[C@H1]1C2CC2)C3=CC=CC=C3 C[C@H1](C(=O)N1[C@H1]2CN(C(=O)C3=CC=C(Br)C(Cl)=N3)C[C@@H1]21)CC=CC=C CCS(=O)(=O)N1CCN(C(=O)C2=CC(Cl)=CC(C)=C2OC)[C@H1](C)C1 CC1=CC=C([C@@H1]2CCCN(CC(=O)NC3=NN=C4C=CC(Cl)=NN34)C2)C=C1 CC1(C)CCC[C@@H1](CC2=CN(C3=CC=C(F)N=C3F)N=N2)C1 COC1=CC=C(C(=O)N2C[C@@H1](NC(=O)CCCCCN)C[C@@H1](F)C2)C(C)=C1 CC(=CC(=O)N[C@@H1]1CN(C(=O)C(F)(F)C2=CN=CC=N2)C[C@@H1]1C)C3=CC=CC=C3 O=C(NCC[C@]1(O)CCCN(C(=O)C2=CC3=CC=CN=C3[NH1]2)C1)C4CC(F)C4 O=C1CC[C@@H1](CNC(=O)[C@H1](O)CNC(=O)C(=O)NC2CC2)O1 CC(C)(CC(N)=O)NC(=O)C1CC(O)(CNC(=O)[C@]23CCCC[C@@H1]2C3)C1 COC1=CC=C(CNC[C@H1]2COCCN2C(=O)C=3C=NSC=3C)C(Cl)=N1 CC1=CN=C(CNCCN2C=C(C(=O)NC3=CC4=CC=CC=C4C=N3)N=C2C)S1 CC(C)C#CC(=O)N[C@@H1](CC(=O)NC[C@@]1(O)C[C@H1]2C=C[C@@H1]1C2)C(F)F CSCCCC(=O)N(C)C[C@H1](O)CN(C)C(=O)[C@@H1]1CC[C@H1](CN2C=CN=C2)O1 C[C@@H1](C(=O)N(C)C[C@H1]1CC[C@H1](CNC(=O)[C@H1]2C[C@](F)(CO)C2)CC1=O)N3CCC3 O=C(NC[C@H1]1CC1(Br)Br)C2=CC3=CC=CC(Br)=C3S2 CCC1=NC=C(C(=O)NC[C@](C)(CO)NC(=O)C2=NON=C2N)S1 CCCCCC[C@@H1](C)CC(=O)NC1(CCNC(=O)C2=CC=CN=N2)CCCC1 C=C(CCNC(=O)CSC=1C=CSC=1[N+1](=O)[O-1])CNC(=O)C2=NOC=C2C3CC3 CC(C)[C@H1](C)[C@@H1](CNC(=O)C=1C=CSC=1)NC(=O)C2=N[NH1]C(C(C)C)=C2[N+1](=O)[O-1] CC(C)(CCCO)NC(=O)[C@@]1(NC(=O)CCC2=CC=CO2)CCSC1 O=C(N[C@@H1](CC1=CN=C[NH1]1)C(=O)NC[C@@]2(Cl)CC2(F)F)C=3C=CSC=3 C#CC[C@H1](CC(F)F)C(=O)N[C@@H1](CCN(C)C(=O)CC1=CC=C(Cl)S1)C(C)C CC1=CC(N)=C(C)N=C1C(=O)N2CC[C@@H1](CN(C)C(=O)COCCCF)C2 CC1=CN=CN1CC(=O)NCCOCCN2C=C(C3=CC(Cl)=CC=C3F)N=N2 CO[C@@H1](CC(C)C)C(=O)N[C@H1](C(=O)N[C@H1]1CCCCC12CC2)C3=CN(C)N=N3 CS[C@H1](C)CC(=O)N[C@H1]1CC[C@@]2(CC1)CN(C(=O)[C@H1]3CCC(F)(F)C3)CCO2 CC1=CC(C(=O)N[C@H1]2CCN(C(=O)CC3=C(C)C=CC=C3Br)C2)=NC=N1 CC1=CC(C(=O)NC2CC(NC(=O)[C@@H1](O)C3=CC=CC=C3)C2)=C(C)S1 COC1CC(CCC(=O)N[C@@H1](C(=O)N2CC3=CC=C(O)C=C3C2)C4(C)CC4)C1 COC1=CC=CC=C1NC(=O)C(=O)N2CCC[C@@H1]3C(=O)N(C)C[C@@H1]32 CCN(C[C@H1](C)NC(=O)C1=C(Cl)CC1)C(=O)C2=CN=C(C)C(Cl)=C2 COC1=NSC=C1C(=O)NC[C@H1]2[C@H1]3CCC[C@H1]2N(C(=O)CSCCN(C)C)C3 C[C@H1](C(=O)NC[C@@H1]1CCOC1)N(C)C(=O)C=2C=NN(C)C=2N CC1=CC=CC=C1CC(=O)N2CCC[C@H1]2C3(C(=O)N4CC[C@@H1](C)C[C@H1]4CC)CC3 CO[C@H1](CC(C)C)C(=O)N[C@@H1]1CC[C@H1](CCNC(=O)C2=CC(F)=C(F)C=C2N)C1 CC1=CN=CC(C(=O)N[C@@H1]2CCC[C@@H1](NC(=O)[C@](C)(CF)C3=CC=CC=C3)C2)=C1 COC1=CC=C(C=2N=C(C=3OC(CO)=CC=3C)N([C@H1]4CCCOC4)N=2)C=C1Cl C=CCC[C@@H1](C)[C@H1](NCCCNC(=O)OC)C1=NN=NN1C(C)(C)C CC[C@H1](O)[C@H1](C)C(=O)NC1CC(NC(=O)C=2C=NSN=2)(C(F)F)C1 COC(=O)[C@H1](OC)C(=O)N[C@H1]1C[C@@H1](OCC(=O)NCC2=NC=NN2C(C)C)C1 C[C@H1]1CC=CC[C@@H1]1C(=O)N2CCC[C@H1](CCC(=O)NCC=3N=N[NH1]N=3)C2 CC1=CC(C)=C(C(=O)NO[C@@H1](CC(C)C)C(=O)N[C@H1]2C[C@H1](CO)C2)S1 C[C@H1](CC(=O)NCCC[C@H1]1CCCN1C(=O)C[C@@H1]2COCCO2)C(F)F COC1=CC(C(=O)NCCCC[C@@H1](C)NC(=O)C=CC2CCC2)=CC3=C1OCC3 CCSCCC1=CN(CCNC(=O)C2=CC=C(S(=O)(=O)NC3CC3)C=C2)N=N1 CC[C@@H1](C(=O)N1C[C@@H1](NC(=O)C=C(C)C2=CC=CS2)OCC1(CC)CC)N(C)C CC1=CC=C(CN2CC[C@@]3(CCC[C@H1]3C(=O)NCC=4N=N[NH1]N=4)C2)C([N+1](=O)[O-1])=C1 C/C=C/C[C@@H1](NC(=O)C1=CC=CC(C)=C1F)C(=O)N2CCC[C@H1](C(C)C)C2 N#CC1=CC=C(CCC(=O)N[C@H1]2CCC[C@@H1]2CNC(=O)CC(F)(F)Cl)C(F)=C1 CC1=CN=CC(C(=O)N2CCO[C@@H1](CCCNC(=O)[C@@H1]3CCOC3)C2)=N1 CC[C@@H1]1CC[C@@H1](C(=O)N2CCC(NC(=O)C3=CC=C4C(=C3)C(=O)C(=O)N4)CC2)C1 CC=1C=COC=1C(=O)NC[C@@H1](CO)NC(=O)C2=CC=C(CC(C)C)S2 CC(C)N1CCC(C(=O)NC23CC(NC(=O)C4=CC=C(Cl)C=C4)(C2)C3)CC1 CC1(C)CN(C(=O)C2=CC=NC=C2O)C[C@@H1]1NC(=O)CN3C=C(Br)C=N3 CC[C@](C)(CCC(C)C)C(=O)N[C@H1](C)[C@@H1](CO)NC(=O)C1=CC=C([S@](C)=O)C=C1 CC[C@H1](CNC(=O)C1=CC=CC2=C1COCCN2)NC(=O)/C=C/CN(CC)CC CCC(CC)(CCNC(=O)C1=CC=CC(C)=C1F)NC(=O)C2=CN=NC(C)=C2C CCCN(CC(=O)N[C@H1]1C[C@@H1](C)N2C=CN=C21)C(=O)C3=CC=C(N)C=N3 C[C@H1](CC(=O)N[C@@H1]1CC2=CC=CC=C2[C@H1]1NC(=O)C3(CN(C)C)CC3)C(F)F C#C[C@H1]1CC[C@H1](C(=O)N[C@H1]2C[C@H1](CNC(=O)[C@H1](C(C)C)N3C=NC=N3)C2)CC1 C=C[C@@](C)(CC)C(=O)N1CC2(CN(C(=O)CN3CCCOC3=O)C[C@@H1]2C(=O)OC)C1 CN(C)C[C@H1](NC(=O)C1=CSC(=N)[NH1]1)C(=O)NOC[C@H1](O)C(C)(C)C CC[C@@H1]1CCCN1C(=O)C(=O)NCC2(CNC(=O)C=3[NH1]C=CC=3C)CC2 COC1(CC(=O)NC[C@H1](O)CN(C)C(=O)[C@@H1]2CCCCO2)CCOCC1 N[C@H1](CC1C=CC=C(NC(=O)CC2CCSCC2)C(F)=C1)CC3CCCC3 CCC[C@H1](NC(C)=O)C(=O)NC1=CN=C(C)N1[C@@H1]2CCCC3=CC=CC=C32 CCC1=NC(C)=C(C(=O)NC2([C@H1]3CCCN(C(=O)CC4=COC(C)=N4)C3)CC2)S1 CCOC(=O)[C@H1]1CCN(C(=O)C2=CC=CC(OC(F)F)=N2)O1 COC1=CC=C(C(=O)NCC(C)(C)CCNC(=O)CC=2C=C(C)ON=2)N=C1 CN1CC[C@H1](C(=O)NCCC[C@@H1]2CCCN2C(=O)C3COC3)C1 CO[C@H1](CN(C)C(=O)CCCC1(NC(=O)[C@@H1]2CC[C@H1]2C#N)CCC1)C3CC3 C=CC[C@@H1](CNC(=O)[C@H1](O)CC)C(=O)NC1=CC=CC(CCO)=C1 CC(C)(C)/C=C/CC(=O)N[C@@H1]1[C@H1]2CCN(C(=O)CCC3=CC=CC=C3F)C[C@H1]21 CSCC[C@@H1](CO)NC(=O)C(C)(C)[C@@H1]1CCCN(C(=O)C=2N=NN(C)C=2N)C1 O=C(COC1CC1)N[C@@H1]2CC[C@@H1](CCNC(=O)C3=CN=C(C(F)F)S3)C2 C=C[C@@H1](CC)CC(=O)N1C[C@H1](N=[N+1]=[N-1])C[C@@H1]1C(=O)N[C@@H1]2CN(C)CC2(C)C CCC(CC)(CO)CNC1=NC(C)=CC(=N[C@H1]2COC3=CC=C(Br)C=C32)[NH1]1 CN1C=C(C=2C=C(C(=O)NC[C@@](C)(O)CNC(=O)C=C(Cl)Cl)ON=2)C=N1 COC1=NN(C)C=C1C(=O)N[C@](C)(CO)C(=O)NC[C@@H1](C)N(C)C2CC2 C=CCC(C)(C)C(=O)NC[C@]12C[C@@H1]1CN(S(=O)(=O)C3=CC=C4N=C[NH1]C4=C3)C2 CC1=NOC(C(F)F)=C1C(=O)O[C@@H1](C)C(=O)N[C@@H1](C)[C@@H1]2CCCO2 CC1=C(N)C=CC(C(=O)N2CCN(C(=O)C3=CN(C)C(=O)N3C)[C@@H1]4C[C@@H1]42)=C1Cl CCCC[C@@H1](CNC(=O)C[C@H1]1C[C@@H1](OC)C1)NC(=O)[C@H1](C2CC2)S(C)(=O)=O C=CCCC(F)(F)C(=O)NCC[C@H1]1COCCN1C(=O)C2CCC2 O=C(C#CC12CC3CC(CC(C3)C1)C2)N[C@@H1]4CCCC[C@H1]4NC(=O)C(F)F CC(=O)NCCCC(=O)N[C@H1]1C=CCN(C(=O)CSC2=CC=C(F)C=C2)C1 CC1=NOC(C(=O)N[C@H1]2[C@@H1]3CN(C(=O)[C@]4(C)CCCCO4)C[C@@H1]32)=C1C(F)(F)F CC[C@H1](SC)C(=O)NC[C@@H1]1CN(C(=O)[C@@H1](F)C(C)(C)O)C2(CCC2)C1 CO[C@@H1](C(=O)N(C)CCC1CCN(C(=O)C=CC=2C=N[NH1]C=2)CC1)[C@H1]3CCOC3 O=S(=O)(NC1CC(CC(F)(F)F)C1)C2=CC=C(NCCCN3C=NN=C3)C=C2Br CC=1C=COC=1C(=O)NCC(C)(C)CNC(=O)[C@H1](N2C=CN=N2)C(C)(C)C CSC1=CSC=C1C(=O)NC[C@@H1](O)CCNC(=O)[C@H1](O)C(C)C C=CCONC(=O)[C@H1]1N(C(=O)[C@@H1]2CC[C@H1]3C[C@@H1]2CO3)CC14CCCC4 O=C(C=CC1CCOCC1)N2CCCCC[C@@H1]2C(=O)N3CCC[C@H1]4COC[C@H1]43 CN(CC1=CC=CC(F)=N1)CC2CN(C(=O)C3=CC=C(O)C(Cl)=C3)C2 C[C@@H1](CC(=O)N1CC(=O)N(CC=2C=CSC=2)CC1)[C@H1]3CCCO3 C=C(CCNC(=O)C1=CC=CC(C2=NN=CO2)=C1)CNC(=O)COCC3CC3 CC[C@H1](CNC(=O)C1(CC2CC2)CC1)NC(=O)/C=C/C3=CC=C(C(=O)OC)N=C3 CC[C@@H1]1C[C@H1]1COC(=O)CC2=CC(OC)=CC=C2OC CC1=NC=C(C(=O)NC[C@@H1](NC(=O)[C@@H1]2C[C@@H1]2F)C(C)(C)C)N1C(F)F CC[C@H1](O)[C@@H1](O)C(=O)NC1=NC=NC(OC)=C1OC CN(CCC1CN(C(=O)C2=CC=CN(C)C2=O)CCC1)C(=O)[C@@H1](F)C(C)(C)O CCC(CC)[C@H1](C)C(=O)N1CCC[C@](CO)(NC(=O)C2=CC(C)=CC(Cl)=C2)C1 CC1=CC=C(C[C@H1](C)C(=O)N[C@@H1]2C[C@H1]3C[C@@H1](C2)N(C(=O)C4=CC=CN=C4)C3)C=C1 COC(=O)[C@H1](OC)C(=O)N(C)[C@@H1](C(=O)NCC1(C#N)CC1)C2CC2 CC1=NC(C(=O)N[C@H1]2CCN(C(=O)CC3=CC=C(O)C=N3)C[C@H1]2F)=CO1 C=C=C(C)CC(=O)N1CC[C@@H1](CO)[C@H1](NC(=O)CN2C=CC(=O)C=C2C)C1 CO[C@@H1](C)C1=CN(C2=CC=CC(C(=O)N(C)C[C@H1]3CC4=CC=CC=C4O3)=C2)N=N1 COC1=CC=C(CN2CC[C@@H1]2C(=O)NC3=NC=CC(F)=C3F)C=C1 CC1(C)C[C@@H1]1C(=O)NC[C@]2(F)CCCN(C(=O)[C@H1]3[C@H1]4CC[C@@]3(C5=CC=CO5)C4)C2 CCC1=NC=NC=C1C(=O)N[C@H1]2CN(C(=O)CCCCCN=[N+1]=[N-1])C(C)(C)C2 CC1=CSC([C@H1](C)C(=O)NC(C)(C)CCNC(=O)C[C@H1]2OCCC2(C)C)=N1 C[C@@]1(C(=O)N2[C@H1]3CC=C(C(=O)NC4(CO)CC4)C[C@H1]2CC3)CCOC1 C[C@H1](NC(=O)C=1C=CN2N=CN=C2C=1)[C@H1]3CCN(C(=O)C4(C(N)=O)CC4)C3 COCCN(CCNC(=O)C1=NC=NN1C)[C@@H1](C)C(=O)NCCN(C)C C[C@H1](CNC(=O)C1=C(Br)C(C2CC2)=NN1)NC3=CC=CC=C3 CCN(C(=O)CC1=CC(C)=NN1C)[C@@H1]2CCN(C(=O)C3(C4=CC(C)=NO4)CC3)C2 CC=1C=NSC=1C(=O)N(C)[C@@H1]2CCN(C(=O)C3=CC=CC(CC(F)(F)F)=C3)C2 CN(C(=O)C#CC1(C)COC1)[C@@H1]2CCN(C(=O)C#CC(=O)N(C)C)C2 CN1C=C(C(=O)NC[C@H1]2CC[C@@H1]2C3=CC=CC=C3)C(C4=CC=C(Cl)C(Cl)=C4)=N1 COCCSCC(=O)N[C@H1]1C[C@H1](C)N(C(=O)C=CC2=NC(C)=CO2)C1 CC=1OC=NC=1C(=O)N2C[C@@H1](F)[C@H1](N(C)C(=O)C=3[NH1]N=CC=3C#N)C2 CCCCOCCN[C@H1](C1=NN=NN1CC2CCOCC2)C(C)(C)[C@@H1]3CCCO3 CCC1=CC=C([C@@H1](C(=O)NC2CC2)N3CCC[C@@H1](C(C)(C)O)C3)C=C1F CCC[C@@H1]1CCN([C@@H1](C(=O)NCCOCC)C2=CC=NC(C)=C2)C1 C[C@@H1]CCC[C@@H1]C(=O)NCC[C@H1]CCCF CC(=CC1CC1)C(=O)NC[C@@H1]2C[C@H1]3CC[C@H1]2N3C(=O)C4=NOCC4 CN(C[C@@H1]1CCCN1C(=O)C2=CC=CC=C2)C(=O)COC3CCCCCC3 O=C(NCCCCNC(=O)C1CN(CC(F)(F)F)C1)C2=CC=CC(OC(F)F)=N2 CC1=NC=CN=C1C(=O)NCCN(C)C(=O)C[C@@H1](C2=CC=C(F)C=C2)C(F)F C[C@@H1](NC(=O)CN(C)C1CCC1)C2(C(=O)NCC3CC3)CC2 CC[C@@H1]1OCC[C@@H1]1C(=O)N2CCC(C(=O)N3CC4(CN(C)CCO4)C3)=C(F)C2 O=C(N[C@H1]1CCN(C(=O)CCC=2C=CSC=2)C13CCC3)[C@@H1]4CCCC=5SC=CC=54 CN1N=C(CN2C[C@H1]3C[C@@H1](NC(=O)C4C5CCC4CC5)CC[C@H1]3C2)C6=C1CCC6 CC1=C(Br)C=CC(C(=O)N[C@@H1]2COCCN(C(=O)[C@@H1](C)CN(C)C)C2)=C1N C[C@H1](O)C(C)(C)C(=O)N1CC[C@](O)(C2CCN(C(=O)C(C)(C)CO)CC2)C1 CC1=NC=C(C(=O)N2C[C@@H1]3C[C@@H1]3[C@H1]2CNC(=O)C=4C=CC5=NC=CN5C=4)[NH1]1 C#CCN1C=C(CNC(=O)[C@H1]2CC[C@@H1](C3CC3)N2C(=O)CCCCC(C)(C)C)N=N1 C#CCN(C(=O)C1=CSC2=C1CCC(C)(C)C2)[C@H1](C)[C@@H1](O)C(C)C CCSC1=CC=CC=C1CC(=O)N2CC3(CCCC3)C4=CC=CC(F)=C42 COC1=NC=C(Cl)C(N2CC[C@H1](C)[C@H1](NC(=O)[C@@H1](C)C3=CC(C)=CC(F)=C3)C2)=N1 CN1C=CN=C1SCCC(=O)N2CC[C@@H1]3CN(C(=O)[C@H1]4CCS(=O)(=O)C4)C[C@@H1]3C2 CC(=O)NCCN(C)[C@@H1](C(=O)NCCC#N)C1=CC=C(C(F)(F)F)N=C1 COCC1=NC(C(=O)NC[C@]2(C)CCCN(C(=O)[C@H1]3C[C@@H1]3C4CCC4)C2)=CO1 CC/C=C/CC(=O)N1C[C@H1]2C[C@@H1](C1)[C@H1](C(=O)N(C)CC3=CC=C(CC)O3)C2 CO[C@@H1]1CCC[C@H1](C(=O)N[C@H1]2CC[C@H1](C(=O)N(C)[C@H1](C)C(C)C)C2)C1 C[C@@H1]1CCN(C(=O)C=2C=NN(C)C=2)[C@H1](CNC(=O)C3(C(N)=O)CCC3)C1 C#CCN(C(=O)C1=NSC2=CC=CC=C12)[C@H1]3CCN(C(=O)CO)C3 C[C@@H1](C(=O)N1C[C@@]2CC[C@@H1](CN(C(=O)CN3C=C(Cl)C=N3)C2)C1)[C@@H1]4CCCO4 C[C@@H1](CNC(=O)C1CCC(C(F)F)CC1)CN(C)C(=O)C2CC(=C3CCC3)C2 C=C[C@H1](O)C(=O)NCCNC(=O)C1=CC(C)=NC2=CC(C)=NN12 CC(=O)CC1(C(=O)NC2C[C@@H1]3CCC[C@H1](C2)N3C(=O)CC4CC(F)(F)C4)CCC1 CCOC(=O)C=1N=C(NC(=O)[C@@H1]2CCCN(CC3=CC=CC(Br)=N3)CC2)SC=1C CCC1(CC)CC(C(=O)N2CCO[C@H1](CC(=O)N(C)C[C@]3(C)CCCO3)C2)C1 C[C@H1](C(=O)N1CC[C@@H1]1CNC(=O)CC(C2CC2)C3CC3)C4=CC=CC=C4Cl C[C@@H1]1CN(C(=O)C=2SN=C(O)C=2Cl)CC[C@H1]1CNC(=O)C3CCC(O)CC3 O=C(C=CCO)NC1(C2(O)CCN(C(=O)CCN3C=NC=N3)CC2)CC1 CC(C)C1=NO[C@H1](C(=O)N2CC(C[C@H1](C)NC(=O)C3CCCCCCC3)C2)C1 C=C(C)[C@H1]1CN(C2=CC=NC(C(C)(C)O)=N2)CCO1 COCCN(CC(=O)N[C@H1](C)COCCOC)C(=O)C=1C=NN(C)C=1OC C[C@](O1)CC[C@@H1](C(=O)NCCN(C(=O)[C@@H1]2CCC3=NN=NN3C2)C4CCCC4)CC1 COCCC(C)(C)CC(=O)NC1(COC)CCN(C(=O)C=CC2CC2)CC1 CCOCCS(=O)(=O)NCC(=O)NC[C@@H1](CC)NC(=O)C1=CC=C([C@H1](C)O)C=C1 CC1=CC(=N[C@H1]2CCC[C@@H1]2C)[NH1]C(N3CCC(C4=CC=CC=C4CO)CC3)=N1 CC1=CC(=NC(=O)[C@@H1](CN2C=CC=N2)NC(=O)C[C@H1](O)CN(C)C)[NH1]N1C CO[C@H1](C)[C@H1](NC(=O)[C@H1](O)C1CCCC1)C(=O)NC(C)(C)CCCN(C)C C/C=C/C[C@@H1](C)C(=O)N[C@@H1]1C[C@H1]2CC[C@@H1]1CN(C(=O)C3=CC(Cl)=CS3)C2 C[C@@H1](CC(C)(C)C)C(=O)NCC[C@H1]1C[C@@H1](NC(=O)CC=2SC=CC=2Br)C1 C[C@H1]1[C@H1](NC(=O)CCC2=CN=N[NH1]2)CCCN1CC3=CC=CC(F)=C3F COCOC1=CC=CC(CNC2=CC=NC(C3=CC=C(F)C(C#N)=C3)=C2)=C1 CC(C)(CNC(=O)C1=CC=CC=2ON=CC1=2)[C@@H1]3CCCCN3C(=O)CC4CC4 CCO[C@@H1]1CN(C(=O)CN2C=CC(Br)=N2)C[C@@H1]1CNC(=O)C=3C=C(C)ON=3 CCC1=CC(C(=O)N[C@H1]2CCCN(C(=O)C3=CSC=C3F)CC2)=C(C)N=N1 CCN(C)CC(=O)N[C@H1]1CCCC[C@H1]1NC(=O)C=2C=C[NH1]C=2C3CCC3 N#CC1(CCC(=O)NC[C@H1]2CCCC[C@H1]2C(=O)N[C@H1](CO)CCCO)CCC1 CCC1=C[NH1]C=C1C(=O)N2CC[C@@H1](N(CC)C(=O)C3=CC4=C(F)C=CC=C4S3)C2 CC(C)N(CCCNC(=O)C1=CN=CC(CO)=C1)CCOCC(F)(F)F COC(=O)C1=CC=C(C(C)=O)C(NC(=O)[C@@H1]2CCCN2C(=O)C3=CC(C)=CS3)=C1 CO[C@H1](CNC(=O)C1=NN(C)C(C)=C1Cl)CN2C=C(CC(OC)OC)N=N2 COC(=O)[C@@H1]1CCN(C(=O)C(C)=CC2=CC=C(Br)O2)O1 C[C@@H1]1CCCC[C@]1(CNC(=O)C[C@@H1]2CCC(=O)NC2)NC(=O)CCC=3N=C[NH1]N=3 CCN1C=CC(C(=O)N2CC3(CCN(CC4=C(Br)C=NN4C)CC3)C2=O)=N1 CC(=CC1CC1)C(=O)N(C)CCN2CCN(C(=O)C=3N=C(C(C)C)OC=3C)CC2 CC=1C=C(CO)OC=1C(=O)N[C@H1](CNC(=O)[C@@H1]2CC3=CC=CC=C32)C(C)(C)C CO[C@H1](CNC(=O)C1CN(C2COC2)C1)CC(=O)N3CC(C4=CC=CC=C4)C3 CCC[C@@H1]1C[C@H1]1C(=O)N(C)CC2(NC(=O)[C@@H1](C)C3=CN=CN=C3)CC2 C=CCC(=O)NC[C@@H1](NC(=O)[C@H1](O)C1CCCCC1)C2CCCCC2 CC[C@]1(C(=O)N2CC[C@@H1](N3C=NC=N3)C2)CCCN(C(=O)CSCCOC)C1 CCN(CC)CCCNC1=NC2=CC=CC=C2N=C1NCC3=CC=CN=C3F C[C@@H1]1CN(C(=O)CC2=CC=C(SC3CC3)C=C2)C[C@@H1]1NC(=O)C(C)(C)CO CC=1C=CN(CCC(=O)N[C@@H1](C)/C=C/C(=O)NC2=CC(C)=CC(O)=C2)N=1 CC(C)N1C=C(C(=O)NC2=CC=CC(C3=CC=C4C=CC=CC4=C3)=C2)C=N1 NC(=O)[C@H1]1CN(C2=CC(NCC3=CC=CC(Br)=C3Cl)=NC=N2)CC14CC4 C=C=CCCN1C=C(C[C@H1](NC(=O)[C@@H1]2CCCN2C(=O)C3CCC3)C(N)=O)N=N1 CCNC(=O)CC(=O)N[C@@H1]1C[C@H1]2CC[C@@H1]1CN(C(=O)C3(SC)CC3)C2 CCCC(C)(C)C(=O)NC[C@@H1](CC(F)(F)F)NC(=O)C[C@H1](CC)CN(C)C C#CCOC1CN(C(=O)[C@H1]2CC[C@H1](C3CC3)N2C(=O)C4=CC=C(C)C=C4O)C1 CO[C@H1](C(=O)NC[C@@H1]1N(C(=O)C23CC(C)(C2)O[C@H1]3C)CCC1(C)C)C(C)C CC(C)N(C(=O)CC[C@@H1](C)NC(=O)C1CC(=O)CC(=O)C1)C2CC2 CN(C)[C@@H1]1CCC[C@H1](NS(=O)(=O)C2=CC=CC(=NCC=3C=COC=3)[NH1]2)C1 CC(C)(C)C/C=C/C(=O)N1C[C@H1](O)C[C@H1]1C(=O)NC[C@]2(C)CNC(=O)O2 CC(C)SCC(=O)NC[C@H1](C)NC(=O)CC1(N(C)C)CCC1 CC1=NN(C)C=C1C(=O)NC[C@@](C)(CO)NC(=O)[C@H1]2C[C@@H1](O)CN2C(N)=O COCC(C)(C)C(=O)N1C[C@@H1](C)C[C@H1](C(=O)NCC=CCSC)C1 CON1C[C@H1](C(=O)NC[C@H1]2C[C@@H1](C(=O)NCCNC(=O)C(C)(C)C)C2)CC1=O C[C@@H1](NC(=O)C1=C(Cl)C=CC=C1Br)C2CN(C(=O)CC3=CN=CN3C4CC4)C2 C[C@H1](CNC(=O)C12CCC(C(F)F)(CC1)C2)CNC(=O)[C@@H1]3OCCOC34CCC4 CC1=NC=C(C(=O)N2CC=CC[C@H1]2C(=O)N[C@H1](C)CN3CCCC3)O1 C[C@H1]1C[C@H1](C(=O)N2CC(CCNC(=O)CSC3=NN=CN3C4CC4)C2)C1(C)C O=C(NCCCO)C12CCC(C1)N(C=3C=NN(C4CCOCC4)C=3)C2 CC[C@H1](CNC(=O)[C@@]1(C)CCCCNC1=O)NC(=O)C2(C)CCN(C)CC2 CCCC[C@H1](C)CCC(=O)N[C@H1]1C[C@@H1](CNC(=O)C2=CC=C(SC(F)F)C=C2)C1 CC(C)/C=C/C(=O)N(C)CCOCCCNC(=O)[C@H1]1C[C@@]1(C)Br CC1(CCN[C@@H1](C2=CSC(Cl)=N2)C3=NN=NN3C4=CC=CC=C4Cl)CCCC1 CC1=C[C@H1](C(=O)N2CC[C@@H1]([C@@H1](C)NC(=O)C3=NN=CC=C3C)C2)SC1 CC(C)C1=CC(C(=O)NC[C@H1]2C=CCN2C(=O)C34CC(C)(C3)OC4(C)C)=NO1 COCC[C@@H1](CNC(=O)C1=CC=C(C)C(F)=C1F)NC(=O)CCC2=CC=CN2C C[C@@H1](C(=O)N[C@H1]1C[C@H1](F)CN(C(=O)CCCCCC#N)C1)S(N)(=O)=O COCCC(=O)N1CC[C@@H1](C(=O)NC2=CN=C(C)C(Br)=C2C)C1 CC(C)[C@H1](C)C(=O)N[C@H1](CCNC(=O)C1(P(C)(C)=O)CC1)CC2=CC=CC=C2 C[C@@H1]1C[C@@H1](CC(=O)N2CCC3=NN(C)C=C3C2)CN1C(=O)C[C@H1]4CSCCO4 CCC1=NC(C(=O)N[C@@H1]2CC[C@@H1](C)N(C(=O)C3CCCCC3)C2)=C(C)O1 CCC[C@](C)(O)C(=O)NCCN(CCCN(C)C)C(=O)[C@H1](O)C1CC(F)(F)C1 CC[C@](C)(OC)C(=O)NC[C@H1](O)CNC(=O)C1=CN2C=C[NH1]C(=O)C2=N1 CCCC[C@@H1](CNC(=O)[C@@H1](CC)OC1CCCC1)NC(=O)C2=CCS(=O)(=O)C2 C[C@@H1]1CCN(C(=O)C2=CC=NC(C#N)=C2)[C@H1](C)[C@H1]1NC(=O)C3=CC=CC=C3Cl CCN1C(C(=O)NC[C@@H1]2CN(C(=O)[C@H1]3C[C@@H1](O)C3)C[C@H1]2C)=NC4=CC=CC=C41 CCOCCOCC(=O)N[C@@H1]1CC2=CC=CC=C2[C@H1]1NC(=O)[C@@H1](COC)N(C)C CN1CCCC[C@H1](NC(=O)[C@H1]2CCCC[C@H1]2CNC(=O)C3=NC=CC=C3N)C1=O CCC[C@H1](C#N)C(=O)N1[C@@H1](C(=O)N(C)C[C@@H1]2CCCN(C)C2)CCC13CC3 C#CC1=CC=NC(C(=O)N(C)C[C@@]2(O)CCN(C(=O)[C@]3(C#N)CCOC3)C2)=C1 CC[C@@H1](OC1CCCC1)C(=O)OCC2=NC=CS2 COCCC[C@@H1](C)C(=O)NCC(=O)NCC(=O)NCCC1(OC)CCC1 CCN1CCN(C(=O)C2(CNC(=O)C(=O)NC(C)C)CCC2)C[C@H1]1C CC1=NOC(C)=C1CC(=O)NCC[C@H1]2C[C@H1](NC(=O)[C@H1](C)N3CCOC3=O)C2 O=C(NCC=1OC=NC=1C(=O)N[C@H1]2CCC3(CCC3)C2)[C@H1]4CCCOCC4 C[C@@H1](NC(=O)CN1CCCC1=O)[C@@H1](C)C(=O)N2CC(N3C=CN=C3)C2 O=C(NC1CC2(C1)C[C@H1]2NC(=O)C3=NC=CN4C=C(Cl)C=C34)C5=CC=C(CO)O5 CC[C@@H1]1[C@@H1](NC(=O)[C@@H1](CC(C)C)C(C)C)CCN1C(=O)COCCF CCCC(C)=CC(=O)N(C)CC1(CNC(=O)CC(=O)N(C)C)CC1 CCCCC1(C(=O)N2CC[C@H1](C(=O)N3CC4=C[NH1]N=C4C3)[C@H1](C)C2)CC1 NC(=O)NC1(C(=O)NCC2CN(C(=O)CC3=C[NH1]C4=CC=C(Cl)C=C34)C2)CC1 CN(C)C(=O)C1=CC=CC=C1C(=O)N2CC(O)(CNC(=O)[C@H1]3CC34CCCC4)C2 CC1=CC([C@H1]2CCN(CC3=CN(C4=CC=C(N)C=C4Cl)N=N3)C2)=N[NH1]1 CCC1=NN=C(N2CC[C@H1](CNC(=O)CNC(=O)OC)[C@H1](C)C2)S1 C[C@@H1](NC(=O)CC(F)(F)F)C(=O)NC1(C)CN(C(=O)C2=CC(C#N)=CN2C)C1 CC[C@H1](O)[C@@H1](C)C(=O)NC(C)(C)CNC(=O)C1=C(F)C=C(O)C=C1F COC1=CC=C2SC(C(=O)NC[C@H1](CO)NC(=O)[C@@H1]3CCCS3(=O)=O)=C(C)C2=C1 CCC1=NN=C([C@@H1](C)N[C@H1](C2=NN=NN2[C@H1](C)CC)C(C)(C)CC)O1 CSC=CC(=O)N1C[C@H1](C)[C@H1](NC(=O)CCCONC(=O)OC(C)(C)C)C1 C[C@@H1]1CCN(C(=O)CSCC2=CSC=N2)C[C@@H1]1NC(=O)C3=CC([N+1](=O)[O-1])=NN3C CC(C)C[C@@H1](C(=O)N1CCCC(F)(F)CC1)N2C(=O)C3=CC=CC=C3C2=O C[C@@]12CC3(F)CC(C(=O)NC4=CC(N5C=CC=C5)=CC=C4Cl)(C1)C[C@](C)(C3)C2 CC(=O)N1CSC[C@H1]1C(=O)NC2(CNC(=O)CCC(=O)N(C)C)CC(F)(F)C2 CCC[C@@](C)(O)CC(=O)NCCC1=CC(C(=O)N(OC)C2CCOCC2)=NO1 CC[C@H1](C)CCC(=O)N(C)CCN(C(=O)[C@@H1]1CC2=C(F)C=CC=C2O1)C(C)C COCC1=C(C(=O)NCCCC(C)(C)NC(=O)C[C@@H1](C)CN(C)C)C=NN1C C#CCCCCC(=O)N[C@H1](CNC(=O)[C@H1]1C[C@H1]1CC)C2=CC=C(OC)C=C2 CCN(CC)CCC(=O)NC[C@@H1]1CCN(C(=O)C2=CN=C3[NH1]C=CC3=N2)C1 O=C(CCC(F)F)N[C@@H1]1CC[C@@H1]2CN(C(=O)[C@@H1]3CC(=O)C34CCC4)CC[C@@H1]2C1 CC1=CC=C(CCC(=O)N[C@H1](C)CCNC(=O)[C@@H1]2CCC(=O)N2C)C(Br)=C1 CC1=CSC(CC(=O)NCC2=CC=C([N+1](=O)[O-1])C=C2Cl)=C1 N[C@@H1](CCCNC(=O)CCC1=CC=CC(Cl)=C1Br)C(=O)O O=C(NC[C@H1](NC(=O)C1=CN=C(CC2CC2)S1)C3CC3)C4=CN=C5C(=C4)CCC5 N#C[C@H1]1CC[C@@H1]1C(=O)NC[C@H1]2C[C@H1](NC(=O)[C@@H1]3CCN4C=NC=C4C3)C2 O=C(N[C@H1]1CCN(C(=O)C2=CC=C3C=CC=NN23)C[C@@H1]1F)C4=CN=C(Cl)[NH1]4 C[C@@H1](O)C(C)(C)CNS(=O)(=O)C1=CC=C(NCC2=CC(Cl)=NO2)C(F)=C1 COC1=CC=C(C)C(CNC(=O)[C@@H1]2[C@@H1]3CC[C@H1]2CN(C(=O)CC4=CSC(C)=N4)C3)=C1 CC[C@@H1](NC(=O)C1(OC)CCN(C(=O)CN2CCSC2)CC1)C3=NC=CN3C CC1=CC(C(=O)N[C@@H1]2CCN(C(=O)C3=CN(CC4=CC=C(F)C=C4)N=N3)C2)=N[NH1]1 CCCC[C@H1](CN=C1C=C[NH1]C=C1C#N)NC(=O)C=2C=CN3C=2CCCC3 CCC1=CN=C(Cl)[NH1]C1=N[C@@H1]2C[C@@H1](OC3=CC=CC=C3)C2(C)C COC1=CC=CC=2SC(C(=O)OCS[C@H1](C(C)=O)C(C)C)=CC1=2 CC(C)[C@@H1]1C[C@H1]1C(=O)N[C@@H1](C(=O)N[C@@H1](C)[C@H1](C)N2C=CC=N2)C(C)(C)C C=C1C[C@@H1](C(=O)NC2=CC=C3C(=C2)C(=O)CCO3)N(CC4=CC=C(O)C(Cl)=C4)C1 COCCN(CCNC(=O)C1=NC(OC)=CC=C1F)C(=O)C(F)=CC2=C[NH1]C=N2 CCCN1C=C(C(=O)N[C@H1]2C[C@@H1](NC(=O)CCC3=CC=CN=C3)C2)C=N1 CC(=O)C(=O)N(CCCN1C=C(CN2CCCC2=O)N=N1)CC3CCCC3 CC1=CSC(CN(C)C(=O)[C@H1]2C[C@@H1](CNC(=O)[C@@H1]3[C@H1]4CC(=O)C[C@H1]43)C2)=C1 CCCN(CCNC(=O)C(C)(C)CNC(=O)OC(C)(C)C)C(=O)[C@H1]1C[C@@H1](C)CO1 COC1(CCNC(=O)[C@H1](F)[C@H1]2CCOC2)CN(C(=O)C=3C=NN(C)C=3)C1 CC(C)C[C@@](C)(CNC(=O)CC(Cl)Cl)NC(=O)CN1N=CN(C)C1=O COC1=C(Cl)C=CC=C1C(=O)COC(=O)C(C)(C)C2=CC=C(O)C=C2 COC[C@]1(NC(=O)C[C@@H1]2CC=CCC2)CCN(C(=O)C3=CC=C(F)C(CO)=C3)C1 CCN(CC)CCC(=O)N1C[C@H1](NC(=O)C2=CC(C)=C(Cl)C=N2)[C@H1](OC)C1 CC1=CC=C(C(=O)NC[C@@H1]2CCC3(CN(C(=O)C=4SC(F)=CC=4Cl)C3)O2)C(Cl)=C1 CCCN(CCC)C(=O)[C@H1]1CCN(C(=O)C2(CC3CCC3)CC2)C(C)(C)C1 CSC=1C=NN(C)C=1C(=O)N[C@H1](CNC(=O)C=2C=C[NH1]C3=NC=CC=23)C(C)(C)C C[C@H1]1CC(=O)NCCN1C(=O)[C@@H1]2CCN(C(=O)CN3CCCC3=O)CCO2 O=C(NC1=C[NH1]N=C1C(F)(F)F)[C@H1]2C[C@H1]2C=3N=C[NH1]N=3 CCC[C@@H1]1CCC[C@@H1]1C(=O)NC[C@H1]2CN(C(=O)C3=CC(O)=CS3)CCC2(F)F CC1=NSC=C1C(=O)N[C@@H1](C(=O)N[C@@H1]2C[C@H1](O)[C@H1](O)C2)C3=CC=CC=C3 CC1(C)CCO[C@H1](CC(=O)N[C@H1]2C=CCN(C(=O)CCC3=CC=CN=C3Cl)C2)C1 CC(F)(F)CCCC(=O)N[C@@H1]1CCC[C@H1]1CNC(=O)CC2=CC=C3N=N[NH1]C3=C2 CC(C)(C)OC(=O)NC[C@H1]1CC(C(=O)N2CC(F)(F)C(F)(F)C2)=NO1 CCC=1C=CSC=1C(=O)N2C[C@@H1](C)[C@H1](CNC(=O)[C@@H1](C)S(=O)(=O)CCC)C2 CC(C)C[C@@H1](C(=O)N[C@H1](CNC(=O)[C@@H1]1OCC1(C)C)C(C)C)N(C)C CC(=O)N[C@H1](C)C(=O)NC[C@H1]1CCN1[C@@H1](C)C(=O)NCC2=CC=C(F)C=C2C CC[C@@H1]1CCCC[C@@H1]1N(C)C(=O)CN(CC(C)C)C(=O)[C@H1](C)CC(C)(C)C CN1C[C@@H1]2C[C@H1]1CN2C(=O)CC[C@H1]3CCCCN3C(=O)[C@@H1]4CCCCN4C CCNC(=O)C(=O)N1CC[C@H1](NC(=O)CCNC(=O)CC(C)C)C[C@@H1]1C2CC2 CNC1=CN=CC=C1C(=O)N2C[C@@H1](NC(=O)CC3=CC=NC(F)=C3)C4(CCC4)C2 CC1=CC(OCC(=O)N[C@@H1](C(=O)NC2=CN=C(F)N=C2)[C@@H1]3CCOC3)=NO1 CCCCCC[C@@H1](C)C(=O)N(C)CC(=O)NC(CC)(CC)CC O=C(CCF)N1C[C@H1]2CC[C@@H1](C1)[C@@H1](NC(=O)[C@H1]3C[C@@H1](N4C=NN=C4)C3)C2 CC=1N=C(C2CC2)[NH1]C=1C(=O)NC[C@@H1]3CN(C(=O)[C@]4(C)CC=CCO4)CCCO3 CO[C@@H1]1CN(C(=O)CCC2=CC=C(Cl)C=C2F)C[C@@H1]1NC(=O)C3=NO[C@@H1](C)C3 CC[C@H1](C)N1C(C2=CC=CC=C2)=NN=C1SCC(=O)NC3=NC4=CC=C(F)C=C4S3 CC=1C=CN(C[C@H1](C)C(=O)NC[C@@H1](CC(C)C)NC(=O)[C@]2(O)CCOC2)N=1 CCCCC=1OC=NC=1C(=O)N(C)[C@@H1](C)CCNC(=O)C[C@H1](C)CF CO[C@H1]1C[C@@H1](C(=O)N[C@H1]2CN(C(=O)[C@@H1](O)C3=CC=CO3)C[C@H1]2C)C1 O=C(C[C@H1]1CCC(=O)N1)NCCC2CN(C(=O)C=3C=NOC=3C4CC4)C2 CC=CC(=O)N1CC(O)(C2(CNC(=O)[C@H1]3CCN4CCOC[C@H1]34)CC2)C1 O=C1C[C@H1](C(=O)N2CC3(CN(C(=O)C4=CN=C5[NH1]C=NC5=C4)C3)C2)CCN1 C1[C@H1]CC=C(C(=O)N(C)C[C@@H1]2CNC(=O)CCCC3CCC3CCO2)C1 CC1=CC=C(C2=NC(C(=O)N3C[C@@H1](NC(=O)C4=CC=NC=N4)CC[C@H1]3C)=CS2)O1 CON=CC(=O)NC1CC2(C1)C[C@@H1]2NC(=O)CC=3C(C)=NN(CC(C)C)C=3C CC1=CC([N+1](=O)[O-1])=CC=C1C(=O)NC[C@@H1](F)CNC(=O)C2=CN(C)N=N2 O=C(NC1=CC(I)=C2C(C=NN2C)=C1)C3=NC(Cl)=CC=C3F CN1C=C([C@H1](NC(=O)C2=CC=C(C3CC3)O2)C(=O)N[C@@H1]4CNC(=O)C4)N=N1 C=C(C)CCC(=O)N(C)CCNC(=O)COC=1C=CON=1 O=C(N[C@H1]1CC[C@H1]2CCC[C@H1]1C2=O)C=3C=C(C4=CC=NS4)ON=3 CCC1=C(C)C=CC=C1C(=O)N2CCCC2CCCC3CCC3 O=C(N[C@@H1]1COCC[C@@H1]1NC(=O)[C@H1](O)C2=CC=CC=C2Cl)C3CCOCC3 CC1(C)C[C@H1](CC(=O)N[C@@]2(CF)CCN(C(=O)[C@@H1]3CCC(=O)NC3)C2)CO1 CCC1=C[NH1]N=C1C(=O)N(CCOC)C2CCN(C(=O)CC(C)(C)COC)CC2 CO[C@H1]1CC[C@@H1]1CC(=O)N2CC(C)(C)C(NC(=O)C3=CC=C(SC)O3)C(C)(C)C2 CC1=NOC(C)=C1C(=O)N2CCCC[C@H1](C(=O)NCCC3=CC=CC=N3)C2 CN1CC(C(=O)NCC2=C[NH1]N=C2C(=O)NCC3=CC=C(C#N)C=N3)C1 CN(CCCNC(=O)[C@H1]1CC[C@H1]([N+1](=O)[O-1])CC1)C(=O)CSCCC(F)(F)F CC=1N=N[NH1]C=1C(=O)NC[C@H1]2CC3(CO2)CN(C(=O)C=C4SCC(=O)N4C)C3 CC1=CON=C1CC(=O)NC[C@H1](NC(=O)[C@@]2(C)C=CCC2)C(C)C CN(CC(=O)N[C@@]1(C[C@H1]2CC2(F)F)CCOC1)CC3=CC=C(Cl)S3 CCNS(=O)(=O)C1=CC=CC(CNC2=CC(C(=O)N[C@@H1](C)CO)=CC=N2)=C1 CCC[C@@H1](C)C=1N=C(C2=CC(OC(F)(F)F)=CC=C2F)N(CCCO)N=1 C[C@H1](O)[C@H1](C)CNC(=O)[C@@H1](CNC(=O)C1=NOC=C1Cl)CC2CC2 COCC=1N=CSC=1C(=O)NC[C@H1]2C[C@@H1](NC(=O)/C=C/C3=CC(F)=CC(F)=C3)C2 O=C(CC1=C[NH1]C2=CC=CC(F)=C12)N3CC[C@@H1](C=4C=CON=4)C3 CN1CCC[C@H1]1C(=O)N[C@](C)(CO)CNC(=O)CC(C)(C)C2=CC=C(F)C=C2 CC1=C(Cl)C=CC=C1C(=O)N[C@H1]2CC23CCN(C(=O)[C@H1]4CC[C@H1]4C#N)CC3 CC(C)(C)C1=NO[C@@](C)(C(=O)NCC2(F)CN(C(=O)CCCS(N)(=O)=O)C2)C1 CCN(C)CCC(=O)N1CCN2C(CNC(=O)CCC3=CN=CN3C)=NN=C2C1 CC1=CC(F)=CC(C(=O)N[C@H1]2CCC[C@H1]2C(=O)N[C@H1](C)C3=CC=CC=C3F)=C1 CCCC=C(CC)C(=O)NCC[C@@H1]1CN(C(=O)C2=CC=NC=3[NH1]N=CC2=3)C[C@H1]1C CCC=1C=C(C(=O)N2C[C@@H1](NC(=O)C3=CC(Cl)=NC=C3O)C(C)(C)C2)ON=1 CCOCC(=O)N1CC2(CCCN(C(=O)C3=CC4=NC=CN4C(O)=N3)C2)C1 CCN1N=C(C(=O)N[C@@H1]2COC[C@H1]2CNC(=O)[C@@H1]3COC(=O)N3)C=C1C(F)(F)F CC1=CC=C([C@@H1](C)C(=O)N2[C@H1]3CC[C@H1]2CN(C(=O)C=4C=C(Cl)N(C)N=4)C3)O1 C=C(C)CCCC(=O)NCCC(CC)(CC)NC(=O)CC1=NN(C)C=C1[N+1](=O)[O-1] C[C@@H1](C(=O)N[C@@]12CC[C@@](CNC(=O)CCN3C=CN=C3)(C1)OC2)N4C=NC=N4 C#CCSCC(=O)N1C[C@H1](NC(=O)C2=CC=CC(F)=C2Cl)C[C@@]1(C)CC CC1(C)CNCC[C@@H1]1C(=O)NC[C@@H1]2CCCCN2S(C)(=O)=O CC[C@H1](SC)C(=O)N1CC[C@H1](CCNC(=O)C2(C3=CC=C(C)C=C3F)CC2)C1 COC[C@@H1](CN1C=C(C2=CC=C(Cl)S2)N=N1)C3=CC=C(Br)C(C)=C3 C#CCN1CCN(C(=O)C2=CC=3C(=O)C=C[NH1]C=3S2)CC1 C[C@H1]1CN(C(=O)CN2CC=CC2)CCCN1C(=O)[C@@H1]3CCCCS3 COC1=CC=C(Cl)C(F)=C1C(=O)N2CC[C@@H1](N(C)C(=O)C3=CC=C(F)C(Cl)=C3)C2 CC[C@H1](C)C[C@@H1](C)N(C)C(=O)[C@@H1]1CCN(C(=O)C=2C=C[NH1]C(=N)N=2)CC1(C)C CN(C(=O)CCCCC1CC1)C2CN(C(=O)C[C@@H1]3CCOC3(C)C)C2 CC(C)[C@@H1]1[C@@H1](NC(=O)C2(C)CC2)CCN1C(=O)C3=CC4=CC(Br)=CN4C=N3 CC(C)(CNC(=O)C(C)(C)NS(C)(=O)=O)CNC(=O)[C@]1(C2CCC2)CC1(F)F COC[C@@]1(C)C[C@H1]1C(=O)NC2(CNC(=O)CCC3=CC=CC=C3O)CCC2 O=C(N[C@]12CCCCC[C@@H1]1N(C(=O)C=3SC=CC=3F)CC2)[C@@H1]4CCC[C@@H1]5C[C@@H1]54 O=C1CC2=C(N=CN=C2N3C[C@H1]4C[C@@H1]3CN4C(=O)/C=C/C5=CC=C(O)C=C5)N1 CCOCCOCCNC(=O)CCN(C(=O)CN1CCOCC1)C(C)C COC(=O)C1=CC=C(S(=O)(=O)NC2=CC=CC([S@@]3(=O)=NCCC3)=C2)C(F)=C1F CC1(NC(=O)C23CCN(CC2)C3)CN(C(=O)[C@@H1](O)C4CCCCCC4)C1 CN(CCCCCNC(=O)[C@H1](O)C1=CC=CN=C1)C(=O)C=2C=C(C(F)(F)F)ON=2 NC1=CC(F)=C(Cl)C=C1C(=O)N[C@@H1](CO)CNC(=O)C=C2CCOCC2 CC(C)(C)C1=CN(CC2=CC=CC(C(=O)N3CC[C@H1]4NC(=O)CC[C@H1]4C3)=C2)N=N1 CN1CC[C@H1](CC(=O)N2[C@H1]3CC[C@@H1]2C[C@@H1]3NC(=O)COC=4C=N[NH1]C=4)C1=O N#C[C@H1]1CN(C(=O)C2C[C@@H1]3CC[C@H1](C2)N3C(=O)C4(CO)CC4)CC15CCC5 CNC(=O)CCCCC(=O)N[C@@H1]1C[C@H1](C)N(C(=O)C2=CN=C3N=CC=NC3=C2)C1 CC1=CC=C(C(=O)NC2(C)CN(C(=O)CN3C=CC4=CC(Br)=CC=C43)C2)O1 O=C(N[C@@H1]1CC[C@H1]2CC[C@H1]1O2)[C@H1]3C[C@H1]4C=CC[C@H1](C4)C3 C#CC1=CC=CC(NC(=O)CC(=O)N[C@H1]2C[C@@H1](NC(=O)C=3C=CC(=O)N(C)N=3)C2)=C1 COC1=CSC=C1C(=O)N2C[C@H1](C#N)[C@H1](NC(=O)C3=CC(Br)=CS3)C2 C=C1CC(NC(=O)OC(C)(C)C)(C(=O)NC2=CC=C(SC3CC3)C=C2)C1 CC=1SN=NC=1C(=O)N2CCC23CN(C(=O)C4=CC(Cl)=C(Cl)N4C)C3 CCCCCC[C@@H1](O)CCC(=O)N1CCN(C(=O)C(C)(C)C2CCOCC2)CC1 CC1=CC=C(C(=O)N2CCC3(CC2)CCN(C(=O)[C@H1](F)CC4CCCC4)C3)N=N1 C[C@H1]1CO[C@H1](C(=O)N2CCC(CCN(C)C(=O)C3=CC=C4[NH1]C=CC4=C3)CC2)C1 CCN(CCNC(=O)C1(CC(F)F)CCC1)C(=O)C[C@H1]2CC[C@H1](O)C2 CC(C)(C)C#CC(=O)N1CC[C@@H1](C2=CN(C3=CC=NC=C3F)N=N2)C1 CC(C)(CF)C(=O)N[C@H1]1C[C@H1](O)CN(C(=O)CCC2=CC=NC=N2)C1 CC1=CN=C(C(=O)NC[C@@]2(C)CCN(C(=O)C3=CC([N+1](=O)[O-1])=CC=C3Cl)C2)C=N1 CCCC[C@H1]1CN(C(=O)CCCC2=CC=CS2)CCN1C(=O)C[C@H1]3CSCCO3 COC1(CC(=O)N2CCO[C@@H1]3CN(C(=O)[C@H1]4C=CCCC4)C[C@@H1]32)CCCCC1 CC(C)(O)C(F)(F)C(=O)N1CC[C@H1](OCCNC(=O)CC(F)(F)Cl)C1 C[C@H1](CNC(=O)COC=1C=CON=1)CN(C)C(=O)C2=CC=CC(C3=CN=CO3)=C2 CCO[C@H1](C)CCC(=O)N[C@H1](CO)CNC(=O)C1=CCN(C(=O)OC(C)(C)C)C1 CCN(C)CC(=O)N1CC[C@H1](CC(=O)N[C@@H1](C)[C@H1](C)N2C=NC=N2)C1(C)C CC1=CC=C(C(=O)N[C@H1]2C[C@H1]3CC[C@@H1]([C@@H1]2F)N3C(=O)[C@@H1]4CCSC4)S1 CC(C)O[C@@H1]1CCCN(C(=O)NC2CCN(C3=NC=CC=C3Cl)CC2)C1 CC1=CC=C(Cl)C(C(=O)NC2(C)CCC(NC(=O)C3CCCCC3)CC2)=C1N C[C@H1]1CCC[C@@]1(NC(=O)C2=CC=CC(CO)=C2)C(=O)N[C@H1]3CC[C@@H1](CO)CC3 C=CCN(OC)C(=O)[C@@H1]1N(C(=O)[C@H1]2CCCN2C3CC3)CCC1(C)C CC1=NOC([C@H1]2CCCN(C(=O)NC3=CC=CC=C3CC4=CC=CC=C4)C2)=N1 CCCN(C(=O)C=C1CN2CCC1CC2)[C@H1]3CCN(C(=O)[C@@H1]4C[C@@H1]5C=C[C@H1]4C5)C3 CN1CCOC[C@@H1](NC(=O)C2C[C@@H1]3CC[C@H1](C2)O3)C1 CCC[C@H1]1CN(C(=O)C2=CC=C(C3CC3)O2)CCN1C(=O)CCC(=O)NC C=C[C@@H1](C)CCNC(=O)CNC(=O)C1=CC=C(N)C=C1 CNC1=CN=NC=C1C(=O)N[C@H1](CO)C(=O)N2CC[C@@H1]2C(C)C COC1=CC=C(C(=O)N[C@]2(CO)CCN(C(=O)C=3C=C(C)OC=3C)C2)C=C1C COCCS(=O)(=O)CC(=O)NC[C@@](C)(F)CNC(=O)[C@@]1(C)CNC(=O)C1 CCC1=NN(C)C([C@H1](C(=O)NCC(C)C)N2CC[C@@](F)(C(=O)OC)C2)=C1Cl FC1=CN=CC(CN2N=C(CCN3C=CN=C3)N=C2C4=C[NH1]N=C4Cl)=C1 C[C@H1]1C[C@H1](NC(=O)[C@H1]2CC23CC(O)C3)CN(C(=O)CC4=C(Cl)C=CC(O)=C4Cl)C1 O=C(COCC1CCC1)N2CC(F)(CNC(=O)[C@@]34CC[C@@](CF)(C3)OC4)C2 COC1=CC=C(C(=O)NC2CCN(C(=O)[C@H1]3NC(=O)O[C@@H1]3C)CC2)C=C1N C/C=C/C[C@H1](CC)C(=O)NCC1(CO)CCN(C(=O)[C@@H1](C)C(F)(F)C(F)F)CC1 CON(CCC(=O)NCC1=CC=CN=N1)C(=O)C2=COC3=CC=CC=C23 C[C@@H1]1CN(C(=O)[C@@H1](O)C2CCCCCC2)CCN1C(=O)C3OCCCO3 CN(C(=O)C1=NC(Cl)=CC=C1N)C2CN(C(=O)C(N)=O)C2 C#CC[C@](C)(NC(=O)C=1C=COC=1CC(N)=O)C(=O)N2CC[C@](C)(O)[C@H1](O)C2 CN(C(=O)CC=1C=CSC=1Cl)[C@@H1]2CC[C@@H1](NC(=O)CC3=C[NH1]N=C3O)C2 CCCCC1(C(=O)NC[C@H1]2CC[C@H1](CNC(=O)C[C@H1]3CC[C@@H1](C)O3)CC2)CCC1 C[C@@H1](CNC(=O)[C@]1(C)OCCC2=CC=CC=C21)NC(=O)[C@@H1](O)C3=CC=CC(N)=C3 C[C@@H1]1CN(C(=O)C2=CC=NC(N3C=NC=N3)=C2)CCCN1C(=O)[C@@H1]4CCC=CO4 CCOCCC[C@@H1](C(=O)NCC1CC1)N2CCC(N(C)CC(F)(F)F)CC2 CCC=1OC=C(C)C=1C(=O)N2CC(CNC(=O)/C=C/C3=CN=CC(O)=C3)(OC)C2 CCCN(C)CC(=O)NC1(CNC(=O)C(C2CCC2)C3CCC3)CC1 CCC=1N=NSC=1CNC(=O)CN(C)C(=O)[C@@]2(C#N)C[C@@H1]3C[C@@H1]3C2 CC1=NC=C(N)C=C1C(=O)NC[C@H1]2C[C@H1](NC(=O)C34CC(C(C)C)(C3)C4)C2(C)C CC1(C)CCN(C2=NN=C(CC3=CC=C(F)C=C3)N2C)[C@@H1]1CNC(=O)CC4CC4 C=C[C@@H1](O)C(=O)N(C)[C@@H1](C)CNC(=O)C1=CC=C(C(C)=O)C=C1F CC(C)N(C)CC1=CN(CC(=O)NC[C@H1](CO)CC2=CC=CC=C2Br)N=N1 CCN(CC)C[C@H1](C)NC(=O)CC(C)(C)N(C)C(=O)C1=CC=CC=C1C#N CC1=CN=C(NC(=O)[C@H1]2CCN2C3=NC=NC=4[NH1]C(C)=NC3=4)C=C1I C[C@@H1](OC1=CC=CC=C1Cl)C(=O)N2CC[C@@](CF)(NC(=O)CC=3C=N[NH1]C=3)C2 CCCN(C(=O)CC1CCOCC1)[C@@H1](C)C(=O)NCCCC2=CC=CC=N2 C#C[C@H1]1C[C@H1]1C(=O)NC[C@H1](CO)NC(=O)C=2C=C(C3=CC=CC(F)=C3)ON=2 C#CCOCCC(=O)N[C@@H1]1CN(C(=O)C2=CC=NN2C(F)F)[C@H1]3CCCC[C@H1]13 O=C(NC1=CC=NC(F)=C1F)[C@H1]2CCN(CC3=C(Cl)C=CN=C3Br)C2 CC1=CC(C(=O)N2CC(F)(F)C[C@@H1]3CCCC[C@@H1]32)=C(C)N1N4C(=O)CCC4=O CCO[C@H1](C)CCC(=O)N1CC[C@](OC)(C(=O)N(C)CCCC(=O)OC)C1 O=C(N[C@H1](CO)CNC(=O)C=1N=N[NH1]C=1C(F)(F)F)C2=CC=C3C(=C2)C(=O)OC3 FC1CCN(C2=NC3=CC=C(NCC4=CC(Br)=CS4)C=C3S2)CC1 C[C@@H1](NS(C)(=O)=O)C(=O)N1C[C@@H1]2CN(C3=CC(OC4=CC=CC=C4)=NC=N3)C[C@@H1]21 C[C@@]1(CCNC(=O)CCC=C(Cl)Cl)CCN(C(=O)C2=NC=CN=C2N)C1 CSCC[C@@H1](O)CC(=O)N1CC(CNC(=O)[C@H1](C)CN2C=CC3=CC=CC=C32)C1 C=C(C)CCCC(=O)N1CC2(CC[C@@H1]2NC(=O)C=3C=CC4=NN=CN4C=3)C1 CC1=CC=CC(OCCN=C(NC[C@H1]2CC[C@H1](C(F)(F)F)O2)NC3CCCC3)=N1 C[C@@H1](CCNC(=O)C1=CSC(=NC2CC2)[NH1]1)NC(=O)[C@H1]3CCOC3 C=CCC1(NC(=O)C/C=C/CC)CN(C(=O)[C@H1]2CCC3=NC(C)=NC=C3C2)C1 CCCC(=O)NCC12CC(NC(=O)[C@H1]3CCC=4C=NN(C)C=4C3)(CCO1)C2 CC[C@](C)(CCNC(=O)C=1C=C(C#N)OC=1C)NC(=O)[C@@H1]2CCC(C)=C(C)C2 C=C1CC[C@@H1]1C(=O)NCCC2=CC=C(N3CCN([C@@H1](C)COC)CC3)C=C2 CCN1C=C(Cl)C(C(=O)N[C@H1](C)CCNC(=O)[C@@H1]2C[C@@H1]3O[C@H1]2[C@H1]4C[C@@H1]34)=N1 C=CC[C@]1(NC(=O)[C@@H1](C)NC(N)=O)CCCN(C(=O)C2=CC=CC(N)=N2)C1 CCC[C@H1](NC(=O)[C@@H1](F)OC(F)(F)F)[C@@H1](O)C(=O)N1CC(C(=O)OCC)C1 CCC[C@@H1](O)CC(=O)N[C@@H1]1C[C@@H1]2CC[C@@]1(NC(=O)C=3C=CC4=NN=C(O)N4C=3)C2 CN(C[C@H1](O)CN(C)C(=O)C(C1CCC1)C2CCC2)C(=O)[C@@H1]3CCCOCC3 C[S@](=O)CCC(=O)NC[C@H1]1CN(C(=O)[C@@]2(C#N)CC2(C)C)C[C@H1]1O CC(=O)N1CC(C(=O)N2C[C@@H1](C)CC[C@H1]2CNC(=O)CC3=CC=C(C#N)N=C3)C1 C=CCC(=O)NC[C@@]1(F)CCN(C(=O)C2=C(F)C=CC(OCC)=C2N)C1 CC1(C)C[C@]1(NC(=O)[C@@H1]2CC3(CCO2)CC3)C(=O)N4CC[C@]5(C=CCO5)C4 N=C1C(Cl)=C[NH1]C=C1C(=O)OCCN2N=C(C3=CC=C(F)C(Cl)=C3)OC2=O CO[C@@H1]1[C@@H1](NC(=O)NC[C@@]2(C)CC(F)(F)C2(F)F)COC13CCOCC3 CC(C)C[C@H1](C(=O)N1C[C@@H1](C(=O)NC2=CC=CC3=C2CCO3)CC(C)(C)C1)N(C)C C[C@]1(NC(=O)C2=NC3=CC=CN=C3S2)CCN(C(=O)[C@@H1](O)CC4=CC=CC=N4)C1 CN(C)C(=O)C(C)(C)C(=O)NCCCOCCC(=O)NC1CC2(CCOC2)C1 CC[C@@](C)(C(N)=O)C(=O)N1CCN(C(=O)C2=NN=C3C=CC=CC3=N2)C[C@H1](O)C1 CCN1C(=O)CC[C@H1]1C(=O)NC[C@@]23CCC[C@@H1](CN2C(=O)CS(C)(=O)=O)C3 CO[C@]1(C2=NC=CN2C)CCN(C(=O)CN3C=C(C=4SC(C)=CC=4CN)N=N3)C1 COC1=CC(Br)=CN=C1N(C)CC2=NC=C(Cl)S2 CC1=CC(C)=C(N2N=NN=C2[C@H1](N[C@H1]3CCCOC3)C=4SC(C)=NC=4C)C(C)=C1 CCN1N=NC(C(=O)NCC(F)=C2CN(C(=O)[C@H1]3CC(=O)N3)C2)=C1C C[C@@H1]1CC2=C(F)C(Br)=CC=C2CN1C(=O)N3C[C@@H1]4CNC(=O)[C@@H1]4C3 O=C(NC1(C(=O)NC2(CC(F)(F)F)CC2)CCCCC1)C3=CC=C(F)C=C3 CCC1(NC(=O)C2(CNC(=O)[C@@H1](O)CCSC)CCC(C)CC2)CC1 C[C@H1](C#N)C(=O)N1CC[C@](F)(CNC(=O)/C=C/C2=CC(Cl)=CC=C2OC(F)F)C1 C[C@@H1]1CO[C@H1](C(=O)NC[C@H1]2CC[C@H1](NC(=O)[C@@H1](CC=3C=CSC=3)NC=O)CC2)C1 CCN1C=CN=C1[C@@H1]2CCCCN2C(=O)C(=O)NC3=CC=CC=C3OC[C@@H1](C)O C[C@H1]1CN(C(=O)COC2CC2)CC[C@@H1]1NC(=O)C3=CC4=CC=CC=C4O3 C[C@H1](C(=O)N[C@@H1]1CCN(C(=O)[C@@H1](F)C2=CC=C(F)C=C2)CC1(C)C)N3CCC3 CC1=CC(C(C)(C)C(=O)N[C@@H1](CO)CNC(=O)C(F)(F)C2=CC=CC(F)=N2)=CS1 C=C1CCN(C(=O)[C@@H1]2CN(C(=O)C3=C[NH1]C=C3C4CC4)C[C@H1]2CC)C1 CCN(C[C@@H1](C)NC(=O)C1=C(F)C=NC=C1Cl)C(=O)C2=CNS(=O)(=O)N=C2C CN1C=CC=2[NH1]C(C(=O)N3CCC[C@@]34CCN(C(=O)[C@@H1]5CCCSS5)C4)=CC=21 C[C@H1](NC(N)=O)C(=O)N1CCO[C@@](C)(CNC(=O)C2=CN=C3C(=C2)CCCC3)C1 COCCOCCOCC(=O)N1C[C@@H1]2CC[C@H1](C1)N2C(=O)C3=CCCS3 CC1=CC=NC(Cl)=C1NC(=O)[C@@H1]2C[C@H1](F)CN2CC3=CC=CC4=C3CCC4 CN(C)[C@H1](CNC(=O)[C@@H1](O)C1=CCCCC1)C(=O)N2C[C@H1]3CCC[C@@]3(CO)C2 C[C@@H1]1CC[C@@H1](NC(=O)[C@H1](O)C2=CC=NN2C)CN1C(=O)COC3=CC=CC=C3F C[C@H1](F)CNC(=O)[C@H1]1CC=C[C@H1](NC(=O)CC2=CN=CN2C)C1 CCC1=CC=C(C(=O)N2C[C@H1](NC(=O)CCN(C)CCO)[C@H1]3C[C@@H1]32)S1 CCN(CC)CCC(=O)N(C)C[C@@H1](C)CNC(=O)[C@]1(C)CCOC2=CC=CC=C21 O=C(CCOC1COC1)NC2C[C@@H1]3CN(C(=O)C4=CN5C=CN=C5S4)C[C@H1]3C2 O=C(C[C@@H1]1CC=CCC1)N2C[C@H1](C=3N=CON=3)C4(CCC4)O2 COC1(CC(=O)NC[C@H1]2CCN(C(=O)C3=CC(C(F)(F)F)=CN=C3O)C2)CC1 O=C(N[C@@H1]1CCCC[C@@H1]1CNC(=O)[C@H1]2CCC3=CC(F)=CC=C32)C4=CC=CS4 CCOCCCCC(=O)N1CCN2N=CC(CN(C)C(=O)CC3CC(C)C3)=C2C1 CO[C@H1]1C[C@@H1](CC(=O)N[C@H1]2C=CCC[C@H1]2C(=O)NCCN3CC[C@@H1](OC)C3)C1 CCN1C=C(N(C)[C@@H1](C(=O)NCC2=CC=CO2)C3=CC=C(OC)C(F)=C3)C=N1 CC[C@]1(C(=O)N2CCN(CC3(NC(=O)[C@H1]4CCCN(C)C4)CC3)CC2)CC1(F)F CO[C@@H1]1CN(C(=O)CC=2C=C(C)ON=2)C[C@@H1]1NC(=O)[C@H1](NC(C)=O)C(C)(C)C CO[C@H1](C(=O)N1C[C@H1](C)O[C@H1](C)C1)C2CN(C(=O)CC[C@H1]3CCOC3)C2 O=C(N[C@@H1]1C[C@@H1]1C(=O)NC2=CC3=C4C(=C2)CCC(=O)N4CCC3)[C@@H1]5CC=CCC5 C=CCC(=O)N(C)C[C@@H1](C)N(C)C(=O)C1=CC2=CC=C(OC)C=C2O1 CC1=CC(C(=O)N2CCCN(C(=O)[C@]3(C)C=CCC3)C[C@@H1]2C4=CC=CC=C4)=CS1 CC(=CC(=O)N[C@H1](C)CC1CN(C(=O)C2=CN=C(Cl)C=C2Cl)C1)C3CC3 COC(C)(C)[C@H1](C)NC(=O)[C@@H1]1[C@H1](C)CN1C(=O)C2=CC(F)=CC(F)=C2 COCC=1C=C(C(=O)NC[C@]23C[C@H1]2CN(C(=O)C[C@H1]4C=NN(C)C4=O)C3)ON=1 CCCN1CCC[C@@H1]1CNC(=O)NC2=CC=C(OC3=CC=CC=N3)C=C2 CSC=CC(=O)N1CC2(CCN(C(=O)[C@@H1](C)C3=CC=CC=C3Cl)CC2)[C@H1]1C(C)C CC[C@@H1](C(=O)NCCCCCN(C)C(=O)C1=C[C@@H1](O)CCC1)N(C)C CN(CCCCNC(=O)C#CC1CC1)C(=O)C2CC3(CC[C@H1]3O)C2 CCC1=CC(CNC(=O)[C@@H1]2[NH1]CCN(C(=O)CCC[C@H1](C)CC)[C@H1]2C)=N[NH1]1 CCC1=NON=C1C(=O)N[C@H1]2C[C@](F)(CNC(=O)C3=C(Cl)C=CC(OC)=C3N)C2 C[C@@H1](C(=O)NCCNC(=O)C1=CC=C2OC(=O)OC2=C1)N3C=NC(C#N)=N3 C[C@H1](C(=O)N1CC[C@@H1](CNC(=O)CSCC(N)=O)C(F)(F)C1)C2=CC=CC=N2 CC[C@@H1](CNC(=O)C1=CC(F)=C[NH1]1)NC(=O)[C@@H1]2C[C@H1]2C3=CC=C(Cl)C=C3 CCOCOC1=CC=CC=C1C2=CSC(NC(=O)C=3SC(Cl)=NC=3Cl)=C2 CCC1=CC=CC=C1CC(=O)NC2(CN(C)C(=O)CSCC(C)C)CC2 CC1=N[NH1]C(C)=C1C(=O)NC[C@H1]2CN(C(=O)C=3N=CSC=3C)CCCO2 CNC=1SC=NC=1C(=O)NCC2=NOC=C2C(=O)N(C)CCN3C=CN=C3 CC(C)C1=NC(C(=O)N2CC[C@H1](C3(NC(=O)C=4C=C[NH1]N=4)CC3)C2)=CS1 C[C@@H1](NC(=O)C1=CC=CN2C=NN=C12)C3(O)CN(C(=O)CN4C=NN=C4O)C3 C1=CC=C(C2=CCNCC2)C=C1CN3CCC4=CC=CC=C4[C@H1]3C5=CC=CC=C5 CCOC(=O)NCCC(=O)N(C)[C@@H1]1CCN(C(=O)CC2=CC(Cl)=CC(Cl)=C2)C1 CCCC(=O)NCC1CN(C(=O)C2=CC=CC(CCC)=C2)C(C3CC3)C1 COCCOC1=CC=C(C2=CC3=C(S2)CCN(CC4=CC(F)=C(F)C=C4Cl)C3)S1 O=C(N[C@]12CCC[C@H1]1N(C(=O)[C@H1]3C(F)(F)C34CCC4)CC2)C=5C=NSC=5 O=C(NC[C@H1]1COCCN1C(=O)[C@@H1]2CCCN3C=NN=C32)C4=CN(C(F)F)C=N4 CCC(CC)(CCNC(=O)C[C@@H1](C)N1CCCC1=O)NC(=O)C2=NC=CC=C2O O=C(C1=CC=C(N2CCOCC2)C=N1)N3CC[C@H1]3CNC(=O)[C@]4(Cl)CC45CCC5 O=C(CCC(=O)N[C@@H1]1CN(C(=O)C23CC(CN2C4CC4)C3)C[C@@H1]1F)C5=CC=CS5 COC1=CC=C2C(=N1)N[C@H1](C(=O)NC[C@@H1]3C[C@H1](F)CN3C(=O)[C@@H1](C)NC(N)=O)C2 C[C@H1](O)CCC(=O)N1CC[C@H1]([C@H1]2CCCN2C(=O)C3=CC=CC4=NC=CC=C34)C1 CC1(C)C[C@@]1(C)C(=O)NCC2(NC(=O)C3=CN=C(O)S3)CCOCC2 COC(=O)NCCCC(=O)N(C)C1CN(C(=O)C=2C=C(CCO)ON=2)C1 C=CCN1C=CC=C1C(=O)N(C)[C@H1]2CCCCN(C(=O)[C@@H1](C)SC)C2 CC1=CC=C(O[C@H1](C)C(=O)N(C)C2CN(C(=O)C3=NOC(C)(C)C3)C2)C(C)=C1 COCC1(NC(=O)C[C@H1](O)C2=CC=CC=C2)CCN(C(=O)/C=C/CCC(C)C)C1 C[C@@H1](CNC(=O)C1(F)CCC1)NC(=O)[C@H1]2CCC=3N=C(O)[NH1]C=3C2 O=C(NC1CC2(CCN(C(=O)C3=CC(Cl)=CC=C3Cl)C2)C1)C4=CC(Cl)=C(Cl)C=N4 O=C(NC1=CC(Cl)=C(Cl)C=C1[N+1](=O)[O-1])[C@H1]2CN(CC3=CC=C(Cl)N=N3)CC[C@H1]2O CC1=CC([C@H1](C(=O)NC[C@@H1]2CCCO2)N3C[C@H1](CO)[C@@H1](CC(C)(C)C)C3)=CC=N1 CC(=CC1=CN=C[NH1]1)C(=O)N(C)C[C@@H1](C)CNC(=O)[C@H1]2CCCC[C@@H1]2C3CC3 CC(C)C1=NC=C(CN[C@H1](C)[C@H1](O)CC2=CC=CC=C2)[NH1]1 CC1(C)C(C(=O)N2CC[C@@H1](CCNC(=O)[C@H1](O)C(F)(F)F)C(F)(F)CC2)C1(C)C COCC1=CC(C(=O)N[C@@H1]2CCC[C@H1]2NC(=O)C3=CC=C(C4=CC=CS4)O3)=NO1 CC(C)CCN(CC(C)C)C(=O)C1C[C@@H1]2CC[C@H1](C1)N2C(=O)C3=CCC[C@@H1]3C C=CC[C@H1](C)C(=O)N1C[C@H1](F)[C@@H1](C(=O)NCC2=CC(C)=CC=C2C)C1 CNC(=O)CC(=O)N[C@@H1]1CN(C(=O)CCSC2=CC=C(C)C=C2)C[C@@H1]1C CC1=CSC(C[C@H1]2CCCN(C(=O)C(=O)NCCC3CC3)C2)=N1 O=CN[C@H1](CC=1C=CSC=1)C(=O)N2CC3(CN(C(=O)C=4C=C(CCO)ON=4)C3)C2 C[C@@]1(CNCC(=O)N2CCC[C@H1]2C(=O)NC3=CC=C(Br)C=N3)CCCS1 CC[C@H1](O)[C@@H1]1CCN1C(=O)C2=C[C@@H1](N)CC2 C=CCCC[C@@H1](NC(=O)[C@@H1](C)C1CCN(C(=O)CC2=CSC(C)=C2)CC1)C3CC3 CN1C[C@H1]2C[C@@]2(NC(=O)C[C@H1](NC(=O)C3=CC=C[N+1]([O-1])=C3)C(F)F)C1 C=CCO[C@@H1](C)C(=O)NCCN(C)C(=O)C=1[NH1]N=C(N)C=1C2=CC=CC=C2 CCOC[C@H1](C(=O)N1CC[C@H1]2CCN(C)C[C@@H1]21)N3C=C(CN4CCOC4=O)N=N3 O=C(C[C@@H1](O)CNC(=O)C(F)F)NC1=CC=CC(O)=C1F C[C@H1](NC(=O)[C@@]12C[C@H1]3C[C@H1]1[C@H1]2C3(F)F)C4(O)CN(C(=O)C5=CCCOC5)C4 COC/C(C)=C/C(=O)N[C@@H1]1CCC[C@@H1]1NC(=O)C2([C@@H1]3CCCCO3)CC2 CN1C=NC2=CC(NS(=O)(=O)[C@@H1](C)C3=CC=CC4=CC=CC=C34)=CC=C2C1=O COC[C@@H1](C)C(=O)N[C@H1]1CCCC[C@@H1]1NC(=O)C=2C=C(C)N(C3CCOCC3)N=2 C[C@@H1]1CN(C(=O)CN2CCC(C)(C)C2)C[C@H1]1NC(=O)CCC=3C=CSC=3 CN(CC(=O)N1CCC[C@@H1]2CN(C(=O)C=3N=CN(C)N=3)CC[C@@H1]21)C4=CC=CC=C4 CP(C)(=O)CCC(=O)NCC1(CNC(=O)C2=CC3=NC(F)=CC=C3O2)CCC1 CCCN(C)CCC(=O)N1CCC[C@H1](N(C)C(=O)[C@@H1]2C[C@@H1](C)CC[C@H1]2C)CC1 C[C@H1]1[C@@H1](C)[C@@H1]1C(=O)N2CCC[C@@H1]2CN(C)C(=O)[C@H1](C)[C@@H1](F)C3=CC=CC=C3 CCC1=CN=CC(C(=O)N[C@](C)(CNC(=O)C[C@@H1]2OCCC=3SC=CC=32)C4CC4)=C1 C1=CC=C(C[C@@H1]2CCCCN2CC3=NN=C(C4=CC=C(Br)S4)O3)C=C1 CN(C)[C@@H1](CNC(=O)COC1=CC=CN=C1)C(=O)NCC[C@@H1]2CCCCO2 CC1=CC=C(CN2C[C@H1](F)C[C@H1]2C(=O)NCC3=CC(Br)=CC=C3F)C=C1C#N C[C@@H1]1CN(C(=O)C=2C=CC3=N[NH1]C=C3C=2F)CC[C@@H1]1NC(=O)C#CC(C)(C)O CCC1=CN=CC=C1C(=O)N2CCC[C@@H1](N(C)C(=O)CCF)CC2 CC1=CC(CC(=O)N(C)CCOCCCN(C)C(=O)CC=2N=C[NH1]N=2)=NN1C C[C@H1](CO)C(=O)N[C@H1]1C[C@@](C)(NC(=O)C2=CC=C(Cl)C(F)=C2N)C1 CC[C@H1]1CC[C@H1](C(=O)N2CC[C@@](C)(NC(=O)C[C@@H1]3C[C@@H1](C)O[C@@H1]3C)C2C)CC1 CCC(CC)(CO)C(=O)NC1CCC(C(=O)NCC2=NC=C(C)O2)CC1 CC(F)(F)[C@H1](F)C(=O)N[C@H1](CC=1C=N[NH1]C=1)C(=O)N2CCO[C@H1](C(N)=O)C2 CCN(CCCNC(=O)[C@H1]1CCO[C@H1]1C)C(=O)C2=CC(F)=C(N)C=C2OC C=CC[C@](C)(CC)C(=O)N1[C@@H1]2CC[C@@H1](C2)[C@H1]1CC(=O)N[C@H1]3C=CCC3 CC1=CC=C(CCC(=O)N[C@@H1]2CCC[C@@H1](CNC(=O)C3(C#N)CCCCCC3)C2)S1 COC(=O)NCC(=O)N1CCC2(CC1)CC(CNC(=O)[C@@H1]3OCCOC3(C)C)C2 CC[C@H1](NC(=O)CN1CC2(C1)CN(C(=O)C3=CC=CC=C3)C2)C4=CC=CC=C4 COC(CNC(=O)NC1=CC(C)=CC([N+1](=O)[O-1])=C1)(OC)C2CC2 CC1(NC(=O)CC2=CC=CC(O)=C2)CN(C(=O)CC3=C(F)C=CC=C3Cl)C1 O=C(CN1CCCCC1)N2C[C@@H1]3CN(C(=O)[C@@H1]4CCC[C@H1](O)C4)C[C@H1](C2)O3 CC1=CC=C(C(=O)NCC2(NC(=O)C3=CN=CC(C=4C=COC=4)=C3)CC2)C=C1O CCCCN(O)[C@H1](C1=N[NH1]C=C1CC)N2CCN3C[C@@H1](C)C[C@@H1]3C2 N=C1C=CC(C(=O)NC[C@H1]2C[C@H1](O)[C@H1](O)C[C@H1]2C(=O)N3C[C@H1](O)[C@H1](O)CO3)=N[NH1]1 O=C(C1=CN=C(Cl)S1)N2CC[C@]3(C[C@@H1]3C(=O)N4CC5=CC=C(Cl)N=C5C4)C2 CC[C@H1](CCCC(=O)N1CCCC[C@@H1]1C)NC(=O)CCCCCN(C)C COC1=CN=NC(OC)=C1C(=O)N(C)CCN(C)C(=O)CC2=C(C)C=CC=C2C CN1N=CC2=CC(NC(=O)[C@H1]3[C@H1]4CN(CC5=CC=C(Cl)C=C5Cl)C[C@H1]43)=CC=C21 C=CCCC(C)(C)C(=O)N[C@@H1](C)CNC(=O)[C@@H1]1CCC2(CCOCC2)C1 CN1N=C2C(=C1C(=O)NC3(CO)CN(CC4=CC=C(Cl)C=C4)C3)COCC2 CO[C@H1](C)C1=NC(CC(=O)N[C@H1]2CCCN(C(=O)C3=C(C)C=CC=C3O)C2)=CS1 CCC1CC(C(=O)N2C[C@@H1]3CC[C@H1](C2)C3NC(=O)[C@H1]4CCS(=O)(=O)N4)CC1 CC1=C(O)C=C(N)C=C1C(=O)N2C[C@@H1]3C(CNC(=O)/C(Cl)=C/Cl)[C@H1]3C2 CCSC1=CC=CN=C1C(=O)N2CCC[C@]3(NC(=O)C=4SC=CC=4F)C[C@@H1]3C2 CC=1C=CSC=1C(=O)NC[C@H1](NC(=O)C2=CON=C2C3CC3)C4CCCC4 CCCN(C)CC(=O)N1CC[C@@]2(C[C@H1]2NC(=O)C3=CC=C4N=C[NH1]C4=N3)C1 C=CCN(CC)C(=O)[C@@H1](CC(C)C)NC(=O)[C@@H1](C)N1C=CN=C1C CCC1=NC(C(=O)NCCNC(=O)C2=CC=C(OC)C=C2)=NN1C3=CC=CC=C3 CC(C)CCSCC(=O)N1CCC(C[C@H1](C)NC(=O)C2=C[C@H1]3C=C[C@@H1](C2)C3)CC1 C[C@@H1](C(=O)N[C@@H1]1[C@H1]2CCN(C(=O)C[C@@H1](C)N(C)C)[C@H1]21)C3=CC=CC(O)=C3 CCN1N=C(C)C(C(=O)N[C@H1]2C[C@@H1]3CC[C@H1]2[C@H1](NC(=O)[C@H1](C)COC)C3)=N1 CCN1C=NC2=C(N3CCN(C4CCOCC4)C[C@@H1](C)C3)[NH1]C(=NCC5CC5)N=C21 CCC1=CC=C(C(=O)N2CC[C@H1](C)[C@H1](NC(=O)C=3N=C[NH1]C4=NC=CC=34)C2)[NH1]1 O=C(C=CC=1C=C[NH1]N=1)N[C@@H1]2CC[C@H1]2NC(=O)[C@H1]3CC4(CCC4)CO3 CC1=CC=C(C2=NC=CC=C2C(=O)N3CCN(C)C[C@@H1]3CO)C=C1 CC1(C)C[C@H1](CNC(=O)[C@@H1]2CCCO2)CN(C(=O)CC3=CC=CC(F)=C3)C1 CC1N(CC)CC(=O)NCCO1 CC1=CC=C(OCC(=O)N(C)[C@H1](C)CN(C)C(=O)C2=CC=C(F)C(F)=C2N)C=C1 CCOCC(=O)N1C[C@H1](C)C[C@H1]1C(=O)NC2=CN(C)N=C2C C#CCC[C@H1](NC(=O)C1CC(OC)(OC)C1)C(=O)N[C@H1]2CC=C(C(C)C)CC2 CCN(CCN(CC)C(=O)CN1CC(=O)NC1=O)C(=O)C[C@H1]2CCCC[C@H1]2F CS[C@H1](C)C(=O)N(C)[C@@H1]1C[C@H1]2C[C@@H1]1N(C(=O)C3=C(C)N(C)C4=NN=NN4[C@@H1]3C)C2 C=CC1(C(=O)N(C)C[C@H1](C)N(C)C(=O)C2=C[C@@](C)(CC)C2)CCOCC1 C=C(C)CCCC(=O)NCC[C@@]12CC[C@@H1]1CN(C(=O)C(OCC)OCC)C2 CC[C@@H1](C(=O)NC[C@@]1(COC)CCCN1C2=CC=C(C#N)C=N2)N(C)C CC=1C=C(CNC(=O)[C@H1](CN(C)CC2=CC=CC=C2)NC(=O)[C@@H1](C)C3CC3)ON=1 CC(C)C1=CC=CC(CC(=O)N[C@H1](CO)CNC(=O)CCN(C)CCO)=C1 CN(CC1(O)CCN(C(=O)CC2=CN=CN2C)CC1)C(=O)[C@@H1](O)C3=CC=CC=C3 C=C[C@@H1]1CC[C@H1]1C(=O)N2CC[C@]3(CN(C(=O)C4=CN=CN=C4)CCO3)C2 CC[C@@H1]1[C@H1](NC(=O)C[C@@H1](C)C(=O)OC)CCCN1C(=O)CNC(=O)OC C=C[C@](C)(O)CC(=O)N[C@@H1](CSCC)C(=O)N1CCO[C@@](C)(CC)C1 CC(C)N1N=CC(C(=O)N[C@@H1]2C[C@H1]3CN(C(=O)[C@@H1]4[C@H1]5[C@H1]6C[C@H1]4C(=O)[C@@H1]56)C[C@H1]32)=N1 CCS(=O)(=O)CC(=O)N1CC(F)(C(=O)N[C@@H1]2C[C@@H1]2C3=CC=C(Br)C=C3)C1 O=C(CN(C(=O)CCC=1C=NOC=1)C2CCC2)NC3(C4CC4)CC3 O=C(C=1C=C[NH1]N=1)N2CC[C@H1](C(=O)N3CCC34CC(O)C4)C2 CC1=CC=CC(CSCC(=O)N[C@H1]2C[C@@H1](NC(=O)C3(C(C)(C)O)CC3)C2O)=C1 CCN(CCC(F)(F)F)C(=O)[C@H1]1CC=CC[C@H1]1NC(=O)[C@H1]2CCO[C@H1]2C(C)C CN1C=NC=C1C(=O)N[C@@]23CC[C@@](CNC(=O)[C@@H1](CO)C4=CC=CC=C4)(C2)OC3 CC1=CC=C(C(=O)NC[C@@]2(C)CCN(C(=O)C3=CN=C[NH1]C3=N)C2)N=C1C CCN1C(=O)C[C@H1](C(=O)N[C@H1]2CCCC[C@H1]2CN)[C@@H1]1C3=CC=CC(C)=C3 C[C@H1](N=[N+1]=[N-1])C(=O)N[C@H1]1CCN(C(=O)C#CC(C)(C)C)[C@H1](C)C1 COC[C@H1](CC(C)C)C(=O)NC/C=C/CNC(=O)C1=CC=C(C#CC2CC2)C=C1 COC1=CC=C(C)C=C1C(=O)CNC(=O)[C@H1]2CCCN2C=O CC1=NOC2=CC(C(=O)N3CC[C@H1](NC(=O)[C@@](C)(O)C4CCC4)[C@H1](F)C3)=CC=C12 COC(=O)C1=CC=C(C(=O)N2CC(OCCNC(=O)[C@@H1](O)CN(C)C)C2)C=C1 COC[C@@H1]1CC[C@H1](C(=O)NCCNC(=O)[C@@](C)(O)C2=CC=CC(F)=C2)C1 CN(C[C@@H1]1CN(C(=O)CNC(=O)CN2C=NC=N2)CCO1)C(=O)[C@H1]3CCC=CO3 CC[C@H1]1OCC[C@@H1]1C(=O)N2CC3(CN(C(=O)CCC4=CN=CC(C)=C4)C3)C2 CCCCNC(=O)[C@]1(CC)CCCN1C(=O)C2=CC=CN3N=CC=C23 O=C(N[C@H1](C1CCC1)[C@H1]2CCOC2)N3C[C@@H1]4CN(C5=CC=CC=C5)C[C@@H1]4C3 CNC(=O)NCC(=O)N[C@@H1]1CN(C(=O)[C@H1](C#N)COC)CC2(CC2)C1 CCCCOC(=O)C=CC(=O)NC[C@@H1]1CCCN1C(=O)C2=CCCC[C@@H1]2C CC[C@@H1](O)C(=O)N1CC2(C(=O)N3CC4(CC[C@H1](C)OC4)C3)CCC1CC2 CCO[C@@H1]1[C@@H1](C)[C@@H1]1C(=O)NC[C@H1]2CCCN(C3=CC(C)=NC(C)=N3)CC2 CC[C@H1](O)[C@H1](C)C(=O)N1CC(CNC(=O)CN2CCSCC2)C1 CON=CC(=O)N[C@@H1]1C2C[C@H1]3[C@@H1](C2)C31C(=O)NC4=CC=CC([C@H1](C)F)=C4 C[C@@H1](NC(=O)CNS(C)(=O)=O)C1CCN(C(=O)[C@@H1]2C[C@H1]2C3=CC=CC(F)=C3)CC1 C=CCCC(=O)N1C[C@H1]2CCN(C(=O)[C@H1](C)C(F)(F)C(F)F)C[C@H1]2C1 CON=CC(=O)NC[C@H1]1CCCCN(C(=O)C=2C=NN(CCO)C=2N)C1 CN(CCN1C=CN=C1)C(=O)C[C@]2(C)CCN2C(=O)C3=CC=C4OC=CC4=C3 CCOC(=O)C1=CC=C2C(S(=O)(=O)NC[C@H1]3CCC(=O)N3C)=C[NH1]C2=N1 CN(C)C(=O)CCC(=O)N(C)[C@H1]1CCN(C(=O)CCN2C=NC=CC2=O)C[C@H1]1C C[C@@]1(C(=O)N2CCCCC[C@H1](NC(=O)CNC(=O)CC3CCCC3)C2)CCCO1 CS[C@H1](C(=O)N(CCNC(=O)[C@@H1]1CCC(=O)N1C(C)C)CC2CC2)C(C)C C[C@@H1](CCNC(=O)CCC1=NC=C(F)C=N1)NC(=O)C2=CN(CC(F)F)C=N2 C#C[C@@H1](CC)NC(=O)C1CCC(NC(=O)C2(F)CCCC2)CC1 CN1CCC[C@H1]1C(=O)N[C@H1]2C[C@](C)(NC(=O)C=CC(=O)NCC3=CC=CN=C3)C2 CC1=CC=CC=C1CCC(=O)N[C@@H1](C)CCCNC(=O)C2=NC3=CC=CC=C3[NH1]2 O=C(NC[C@H1]1CC[C@H1](NS(=O)(=O)CCC2=CC=CC=C2)CC1)C3=CC=CC(O)=N3 O=C(CC1=CCOCC1)N2CCC[C@@H1]2[C@@H1]3CCCN3C(=O)C4CCC(CO)CC4 C#CC1=CC=C(C(=O)N2C[C@H1](NC(=O)C3=C(C)OCCC3)[C@@H1]4C[C@@H1]42)N=C1 CCCCCCCC(=O)N[C@H1]1C[C@@H1](CNC(=O)C2=C3CCCN=C3NN2)C1 CC[C@@H1]1CCCC[C@H1]1C(=O)NCCCN(C)C(=O)C2=CC=C(N(C)C)C=C2 CCCN1CCCC[C@H1]1C(=O)N[C@@H1](CO)CNC(=O)C(=O)NC2=CC=CC(C)=C2 N#CC=1N=C[NH1]C=1C(=O)N2CC[C@H1](NC(=O)[C@@H1](O)COCC3=CC=CC=C3)C2 CC[C@@H1](CC(=O)N1CC([C@@H1](O)C(=O)N2CCN(C)C[C@H1]2C(C)C)C1)SC CCN(C(=O)C(C)(F)F)[C@H1]1CCCN(C(=O)[C@@H1]2C[C@H1](C)CC(=O)N2)CC1 CC1(CN(C(=O)[C@@H1]2CCCS2)C3=NC(C4CC4)=NC5=CC=CC=C35)CNC1 CN1C=C([C@@H1](O)C(=O)N2CC=C[C@H1](NC(=O)CSCC3=NC=C[NH1]3)C2)C=N1 CCOCCOCCC(=O)N(C)CC1(CNC(=O)CC2=CC=CS2)CC1 CC1=CC=CC(NC(=O)[C@H1](CC(C)C)N2CCC(O)(CCO)CC2)=N1 CC1(C)CN(C(=O)COC2CC2)CCN(C(=O)[C@H1]3CC(=O)N(C4=NC=CS4)C3)C1 C[C@H1](C(=O)N1CCOCC1)C(=O)N2CC[C@H1](NC(=O)C3(CCO)CC3)[C@H1]2C CC(C)(CCCNC(=O)CCN1C(=O)CCC1=O)NC(=O)[C@@H1](F)[C@H1]2CCOC2 C=CC[C@@H1](CC)C(=O)N1CCCN(C(=O)CSC2=CC=CC=C2C)[C@H1](C)C1 CCC[C@@H1]1CCC[C@@H1]1C(=O)N[C@@H1]2CN(C(=O)[C@](C)(CC)OC)CC3(CC3)C2 CC(C)[C@@H1](CCNC(=O)C1=CN=C2N=CNN2C1)NC(=O)CCSCC(N)=O C#CCC(C)(C)C(=O)NC[C@@H1](NC(=O)[C@@H1](F)C(C)C)C1=CC=CC(OC)=C1 CC(C)[C@@H1](CCN(C)C(=O)[C@H1]1C[C@@]2(C)C[C@@H1]1CO2)NC(=O)C3=CN=CC(F)=C3Cl COC1=CC=CC2=C1C[C@H1](C(=O)N(CC(=O)NC3CC3)[C@H1]4C[C@H1]5C[C@H1]4CN5)CC2 CO[C@H1]1CC[C@@H1]1CC(=O)NCC2CC3(C2)CN(C(=O)CC4(CO)CCC4)C3 CCC[C@H1](C)CC(=O)NC[C@H1]1CN(C(=O)C2=CC=NC=3[NH1]C(C)=NC2=3)CC[C@H1]1C CC(C)C1=C[NH1]C=C1C(=O)N2C[C@H1](C)[C@@H1](C(=O)NCC3=CC(O)=NS3)C2 CC[C@@](C)(CO)C(=O)NC[C@]1(C)CCCN(C(=O)C(=C(C)C)C2=CC=CC=C2)C1 CCCCS(=O)(=O)CC(=O)NC[C@@]1(O)CCN(C(=O)C2=CC(F)=C(C)C=C2N)C1 CC=CC(=O)N[C@@H1]1CN(C(=O)[C@@H1](O)C(C)(C)C)CC(C)(C)C1 CC1=CC=C(/C=C/C(=O)N[C@@H1]2CCCC[C@H1]2NC(=O)C3=CC=NN3C(F)F)C=N1 CC[C@H1]1OCC[C@H1]1C(=O)NC2(COC)CN(C(=O)CNC(=O)C=3C=COC=3)C2 C=C(CCNC(=O)C[C@@H1](C)C1=CC=CO1)CNC(=O)C[C@H1]2CC3CCC2CC3 CCC1=CC=CC(C(=O)N[C@@]23CCCN(C(=O)C4=CC=C(C)N=N4)[C@@H1]2C3)=C1 CC[C@@](C)(CNC(=O)C1=CC2=C(C)C=C(C)C(C)=C2[NH1]1)NC(=O)[C@H1]3C[C@H1]3CN=[N+1]=[N-1] COC(=O)[C@@H1]1CCN([C@H1](C(=O)NCC2=CC=CO2)C3=CC4=CC=NC=C4S3)C1 CO[C@H1](C)C1=NC(C(=O)NCCCCN(C)C(=O)[C@@H1]2CCOC(C)(C)C2)=CO1 CC1(NC(=O)CC(Cl)Cl)CCN(C(=O)C2=CC=CC3=CC=NN23)CC1 C[C@@H1]1C[C@@H1](CNC(=O)C2=C[NH1]C(=N)S2)CCN1C(=O)[C@@H1]3CCCC4=CC=CN=C43 CCN(CCNC(=O)[C@@H1]1C[C@H1]1C2CCCC2)C(=O)CSC(F)(F)F O=C(CCSC1CCCC1)NC[C@@H1]2CC[C@H1](NC(=O)C[C@H1]3COCCO3)C2 C=C(C)[C@H1](CC(=O)NC[C@@](C)(NC(=O)C1=NN=C(O)C=C1O)C2CCC2)OCC O=C(CC1=CN=CN=C1)N2[C@@H1]3CN(CC4=CN=C5C=CC=CC5=N4)C[C@H1]32 O=C(C1=CC=C(Cl)C=C1F)N2CC[C@](CF)(NC(=O)[C@H1]3C[C@](F)(CO)C3)C2 CCCCCCC(C)NC(=O)C[C@H1](C1=CC(Cl)=CC(Cl)=C1)N(C)C CN(C)C(=O)CCC(=O)N1CCC2(CC1)C[C@@H1]2NC(=O)C3(C)C[C@@H1]4C[C@H1]4C3 CN1CCN(C(=O)[C@@H1]2CC3(CC3)CN2C(=O)C4=CC=NN4CCF)CC15CCC5 CC1=CC=CC=C1CN(C)C(=O)CN2C[C@H1]3CCC[C@@]3(C(=O)O)C2 CC[C@H1](C#N)C(=O)NC[C@](C)(NC(=O)C1=C(Cl)C=NN1C)C2CC2 COCC(F)(F)C(=O)NC[C@H1]1C[C@@H1](NC(=O)C2=CC(OC)=CC=C2C(=O)OC)C1 C[C@@H1](CC1=CC=CC=N1)NS(=O)(=O)C2=CC=CC(=NCCC3=CC=CC(N)=C3)[NH1]2 CCC[C@@H1](NC(N)=O)C(=O)N1CCCC[C@@H1]1[C@H1](C)NC(=O)[C@]2(C#N)CC23CCC3 CN1C=NC(C[C@H1](O)C(=O)NCCN(C)C(=O)CCC2=NC=CS2)=C1 CC=1C(C(=O)N2CC[C@@H1](C(=O)N(C)[C@@H1]3CCSC3)O2)=C[NH1]C=1C#N CC(C)(F)[C@@](C)(F)C(=O)NC[C@@H1]1COCCN(C(=O)CNC2=CC=CC=C2Cl)C1 CCCC[C@H1](F)C(=O)N[C@H1](CC(=O)NCC[C@@H1](C)C(F)F)CC(C)C C=C[C@@H1](C)[C@@H1](C)C(=O)N1CCC(COC)(NC(=O)CC2=CN=C(C)[NH1]2)CC1 C[C@@H1]1[C@H1](O)CCCN1C(=O)[C@@H1]2C[C@H1]3C[C@H1]3N2C(=O)CC4=CC=C(Cl)S4 CO[C@H1]1C[C@@H1](NC(=O)[C@H1]2CC[C@@H1](C)O2)CN(C(=O)C3=CC=CC4=NC(C)=NN34)C1 C#CCC[C@@H1](O)C(=O)NC1(CNC(=O)[C@@H1]2CCCN3C=NN=C32)CC1 CCOC(=O)C(C)(C)CC(=O)N1CCN(C(=O)C[C@@H1]2CCCC[C@H1]2O)[C@H1](CO)C1 C#CC[C@]1(C(=O)NC[C@H1]2CC(C(=O)NCCC=3OC=NC=3CO)=NO2)CCOC1 C=CCOCCCC(=O)N1C[C@@H1]2CC[C@@H1](N(C)C(=O)C3=CN=C(C)[NH1]3)[C@H1]2C1 CC(C)(COCC(F)F)C(=O)NCC1(F)CN(C(=O)CCOC[C@H1]2CCCO2)C1 CCC1=CSC([C@H1]2CCCN(C(=O)C3=CC=C(COC4=CC=C(Cl)C=C4)O3)C2)=N1 CCC=1SC(C(=O)N2CCC3(CCC[C@H1]3CNC(=O)CC[C@H1](C)O)CC2)=CC=1C COC1=CC=CN=C1CCC(=O)N2CC3(CC[C@H1](NC(=O)C4=CN=CN4C)C3)C2 CCN(CC1=CC=CC=C1)[C@H1](C(=O)NC2CC(F)(F)C2)C3=CC=CC4=C3COC4 C[C@H1]1CCC[C@@H1](CC(=O)N[C@@H1](C(=O)NC=2C=NC3=NC=NN3C=2)C4CC4)O1 C[C@@]1(CNC(=O)CCOC2CCCC2)CCN(C(=O)CN3C=NN=N3)C1 COCC=1C=COC=1C(=O)N(CCCCCNC(=O)C2=COC=N2)C(C)C O=C(CCCC=1C=CSC=1)N[C@@H1]2CCC[C@H1]2CNC(=O)C3=CC=NC(O)=C3F CO[C@H1]1C[C@@H1](CNC(=O)C2=CC3=CC=CN=C3C=N2)N(C(=O)C=C(C)C(F)F)C1 N#CCN1C=CC(C(=O)NC[C@@]2(O)CCN(C(=O)C3=CN=CC([N+1](=O)[O-1])=C3)C2)=N1 CC1=CC(C)=C(C(=O)NC[C@H1]2C[C@H1](CNC(=O)CCN3C=CN=C3)C2)C(Cl)=N1 CO[C@H1](C(=O)NC[C@@H1]1CCN(C(=O)C[C@@](C)(O)C(F)(F)F)C1)C=2C=NN(C)C=2 CC1=CC(C2=CC=C(C3=CC=C(C(=O)N4CC=CC4)C(C)=N3)C=C2)=CC=C1CO CC#CC[C@H1](NC(=O)C1=N[NH1]C2=C1COC2)C(=O)N(C)CC3=CC=NS3 CC(=O)N[C@@H1]1CCCN(C(=O)[C@@H1]2CCCN2NC(=O)CSCCC#N)C1 COCCN(CC(=O)NC1=CC=CC2=C1CCO2)C(=O)C3=CC=[N+1]([O-1])C=C3 C#CC[C@H1](O)C(=O)NC[C@]1(C)CN(C(=O)C=2SC=CC=2C)C[C@H1]1C CCN1N=NN=C1[C@H1](NCC=2SC(Cl)=CC=2Br)C3(C(F)F)CCC3 CC(C)CSCC(=O)N1CC[C@@]2(CCN(C(=O)[C@H1]3CCCC=4N=C[NH1]C=43)C2)C1 N#CC1=CC=C(C(=O)N2CC3(CC[C@H1](CNC(=O)C4(F)CC4)O3)C2)N=C1 CCOC1=CC=C(C(=O)NC2[C@H1]3C[C@H1]2CN(C(=O)[C@H1]4CN(C)CCO4)C3)C=C1C O=C(C=C1CCCCC1)N[C@H1]2C[C@@H1](CO)N(C(=O)CCC3=CC=CS3)C2 COC(=O)C1=CC(Br)=C2C(=C1)CN(C(=O)C[C@]3(C)CCNC3)CCO2 C[C@@H1](C(=O)N[C@H1](CCC(N)=O)C(=O)O)N1C=C(C2=C(F)C=C(Cl)C=C2Cl)N=N1 CC(C)(C)N1C=CN=C1[C@@H1]2CN(C3=NC=CC(C4CC4)=N3)C[C@H1]2O C[C@@H1]1OCCC[C@@H1]1C(=O)NC[C@@H1]2C[C@@H1]3CC[C@H1](C2)N3C(=O)C4=CN=C(Cl)C=N4 CCC[C@H1](C)N(C)C(=O)C=1C=C(CNC(=O)C[C@H1](C)N2C=CC=N2)ON=1 COC(=O)CN1N=NC2=C(N[C@@H1](CO)CNC(=O)C(N)=O)N=CN=C21 CC1=C(C(=O)N[C@@H1](C)CC2CCN(C(=O)C=C3CCC(C)CC3)CC2)CCCO1 C=C=CCCC(=O)NC[C@@H1](CC(C)C)NC(=O)[C@@H1](O)CC1CCOCC1 CCCC(C)(C)C(=O)NCC1CCC(NC(=O)C=2SC(C(C)(C)C)=NC=2C)CC1 CCOC=1OC(C)=NC=1C(=O)N2CCO[C@H1]([C@H1](C)NC(=O)[C@H1]3C[C@@H1](F)C3)C2 CC(C)C[C@@](C)(CNC(=O)CC1CCC2(CC1)CC[C@@H1]2O)NC(=O)CNC=O COC1=CC=C(Cl)C=C1CC(=O)N[C@@H1]2C=CCN(C(=O)C3=CCN(C)C3)C2 CCCC(C)(C)CNC(=O)C1=COC(CNC(=O)COCC2CCC2)=N1 CCS(=O)(=O)CCN(C)C1=NC2=CC=CC=C2N=C1NCC=CC3CC3 CCCOC(=O)C[C@@H1]CNC(=O)[C@@]1(C2CCCC2)CCNC1 CCC=1N=NSC=1C(=O)N2CC3(C2)CN(C(=O)C=CC4=CC=CC=N4)CCO3 CC1=NN2C=NN=C2C(C)=C1CCC(=O)OC[C@H1]3CCC4=CC(I)=CC=C4O3 CO[C@@H1](C)CCC(=O)N(C)[C@@H1](C)CNC(=O)CC1=CC=CC=2OC=CC1=2 CC1=CC(F)=CC(C(=O)N2CCN(C(=O)C3(C)COC3)[C@@H1](C(F)(F)F)C2)=C1 CC[C@](C)(C#N)C(=O)N1CC[C@H1](CC2=CN(CC[C@H1]3CC3(Cl)Cl)N=N2)C1 COC1(CNC(=O)[C@H1](C)C=2C=C[NH1]N=2)CN(C(=O)/C=C/CN3CCCCC3)C1 CCCC[C@@H1](CN=C1C=C(C)C(C#N)=C[NH1]1)NC(=O)C2=CN=C3[NH1]N=NC3=C2 COCCN1N=CC=C1NC(=O)[C@@H1]2CN(C(=O)C3=C(F)C=CC(F)=C3Cl)CCN2 CN(C(=O)[C@@H1]1C[C@@]1(C)Br)[C@@H1](CNC(=O)C2(C3=CC=NC=C3)CCC2)C4CC4 CCC(=O)N[C@H1]1CC[C@](F)(CNC(=O)C2=CC=C(Cl)S2)C1 CC(C)C=1C=C(C(=O)N2CC[C@H1](NC(=O)C3=NNC(=O)CC3)[C@@H1](CO)C2)N(C)N=1 C[C@@H1](CC1CCCCC1)C(=O)N[C@@H1]2CN(C(=O)CC(C)(C)O)CC3=CC=CC=C32 CN(C)C1=NC=C(C(=O)N[C@@H1](CNC(=O)C=2C=NSN=2)[C@H1]3CCOC3)S1 CC1=CC=C(C(=O)N2CC[C@@H1](O)[C@H1](C(=O)NC=3[NH1]N=C4C=NC=CC=34)C2)S1 CCC1=NOC2=NC=C(C(=O)NC3CC(NC(=O)[C@@H1](C)C(F)F)C3)C=C12 COCCN1C[C@H1](C(=O)N2CCC[C@@]2(C)CNC(=O)CCC(C)(F)F)CCC1=O C#CCCC(=O)N1CC[C@@H1](C)[C@H1](CC(=O)NC2=CC=C(O)C3=CC=CC=C23)C1 CCN1C=NC=C1CNC(=O)[C@@H1]2C[C@]23CCN(C(=O)CCCC(C)(C)C)C3 CS(=O)(=O)SCC(=O)NCC1(F)CCN(C(=O)C[C@@]2(O)CCOC2)CC1 C#CCCCN(C)C(=O)[C@@]1(CNC(=O)[C@H1](CC)CN(C)C)CC12CCC2 CON(CCC(=O)N1CC[C@@H1](OCC2CC2)C1)C(=O)C3CC(F)C3 CC1=NC=CC=C1C(=O)N2CCC[C@H1](C3(NC(=O)C[C@H1]4CC(C)(C)CO4)CC3)C2 O=C(N[C@H1]1C[C@H1]1NC(=O)C2=CC=3SC=CC=3C(=NCC4CC4)[NH1]2)C5=NOCC5 COC1=CC=C2C=CC(C(=O)N3CC(NC(=O)[C@H1]4COCC[C@H1]4C)C3)=CC2=C1 CC(C)C1(C(=O)NC[C@]2(O)CCN(C(=O)CCC3=CC=NC=N3)C2)COC1 C=CC1(CC(=O)N2CC(NC(=O)[C@@H1](C)OC3=CC=C(C)C=C3)C2)CCCCC1 CO[C@@H1]1C[C@@H1](C)CN(C(=O)C2(NC(=O)[C@@H1]3CCOC3(C)C)CSC2)C1 O=C(NC1(C2=CC=NC=C2)CC1)[C@@H1]3C[C@@H1]4C[C@H1]4N3CC5=CN=C6C=C[NH1]C6=C5 CCC=1[NH1]C(=N)SC=1C(=O)NCC2CN(C(=O)CN3N=C(C)N(CC)C3=O)C2 CCCC1=CC(C(=O)N[C@@H1](C)C2CN(C(=O)CCNC(=O)OCC)C2)=C(C)O1 O=C(N[C@@H1]1COC[C@H1]1O)C2(O)CCN(C3=CC=C(Cl)C=C3Cl)CC2 C[C@@H1]1CCOC[C@@H1]1C(=O)NCC(=O)NC[C@@H1]2C[C@H1](O)C23CCC3 CC1=CC=CC(CN2CCOC[C@H1](C(=O)N[C@H1]3C[C@H1](C4=CC=CC=C4)C3)C2)=N1 C=C1CC(CC(=O)N2[C@H1](C(=O)N3CC(OCC(C)C)C3)[C@H1]4CC[C@@H1]2C4)C1 C=CC(C)(C)CC(=O)N1CC[C@H1](C)[C@@H1]1C(=O)NCCC2=N[NH1]C(C)=N2 CCN=C(NNCCC(C)(C)C)N1CCN(C2=CC=CC=C2OCCC(C)C)C1 O=C(NC1CC2(C1)C[C@H1]2N=C3[NH1]N=C(CO)S3)C4=CC=NC5=NC=NN45 C#CCOCCC(=O)N(C)CCCN(C)C(=O)[C@H1]1C[C@H1]2CC[C@H1]1O2 O=C(NCC1=CC=CS1)[C@H1](C2CCCCC2)N3CCN(CC=4C=NSC=4)CC3 C[C@H1]1CC[C@@H1](C)N1[C@H1](C)C(=O)N[C@@H1]2CC[C@H1]3C[C@H1]2CN3C(=O)[C@H1]4CC=CCO4 NC(=O)NC1=CC=CC=C1C(=O)N2C[C@@H1](F)C[C@H1](NC(=O)CC3(O)CC3)C2 C[C@@]1(C(=O)N[C@@H1]2C[C@H1]2CNC(=O)C3=CN4N=CC=CC4=N3)CCC5=CC=CC=C51 C=C=C(C)CC(=O)N[C@H1]1C[C@@H1](CCNC(=O)CCOC(C)C)C1 NC(=O)C[C@@H1](NC(=O)[C@H1](O)C=1C=CSC=1)C2=CN(C3=CC=C(I)C=C3Br)N=N2 COC1=CC=C([C@H1](C)CC(=O)N2C[C@@H1](O)[C@H1](N(C)C(=O)C3=CC=CO3)C2)C=C1 CCCCCC1=CC=C(C(=O)NC[C@H1](NC(=O)CCOCC)[C@H1](C)C(C)C)O1 CC1=CC=CC(C)=C1NCC(=O)N[C@H1](C)C2CN(C(=O)C[C@@H1]3C[C@@H1](C)O[C@@H1]3C)C2 COC(=O)[C@@H1]1CCCN(C(=O)[C@@H1](OCC(C)C)C(C)C)C1 COCCSCC(=O)NC[C@@H1]1CC2(CCC2)CN1C(=O)CN(C)[C@@H1]3CCSC3 CC(C(=O)NCC1=CC=C(Br)C=C1OC2=CC=C(Cl)C(Cl)=C2)=C3CCC3 C[C@H1](C(=O)N1CCC[C@H1](CNC(=O)/C=C/C(=O)OC(C)(C)C)C1)C2CCC2 C=C[C@H1](C)[C@H1](C)C(=O)NCCC1(NC(=O)C2=CC=C(CC)C(OC)=C2)CC1 CC1=CC=CC(C(=O)N[C@H1]2CN(C(=O)[C@H1]3C[C@@H1](N(C)C)C3)CC[C@@H1]2C)=C1C CCS[C@H1](C)C(=O)N1C[C@H1]2C(CNC(=O)C=3C(C)=NN(C)C=3F)[C@@H1]2C1 O=C(N[C@H1]1C=CC[C@H1](C(=O)O)C1)C2=CC=3SC=CC=3[NH1]2 CC1(C)CC(CC(=O)NCC2CCCCN(C(=O)CCC3=CC=CC=C3Cl)C2)C1 CN(C)CC1(O)CN(C(=O)[C@@H1](CCF)NC(=O)C2CC(F)C2)C1 C#CCCN(C)CC(=O)NCC[C@@]1(O)CCN(C(=O)C=2OC=CC=2C(=O)OC)C1 C#CCCCC(=O)N1C[C@@H1]2CN(C(=O)[C@H1]3COCCN3CC)C[C@H1](C1)O2 CC(C)N(C)CC(=O)N[C@H1](C(=O)NCC1CC(O)C1)C=2C=NN(C)C=2 CCOCC(=O)NCC=1C=C2N(N=1)CCN(C(=O)C3CC(C)(CC)C3)C2 C[C@@H1](NC(=O)[C@]1(C)C=CCC1)C2CN(C(=O)C3=CC4=C(Cl)C=CC=C4S3)C2 CO[C@H1]1C[C@@H1](CC(=O)N2CCC([C@@H1](C)NC(=O)C=3OC=CC=3C4CC4)CC2)C1 CCCCC[C@H1](F)C(=O)N1CCN(C(=O)C[C@@H1]2CNC(=O)O2)C[C@@H1]1CCC C#CC[C@H1](CCOC)NC(=O)[C@H1](C)NC(=O)[C@@H1]1CC[C@H1](C#C)O1 CC[C@H1](C(=O)NCC[C@]1(O)CCN(C(=O)CC2=CC=CC=C2C)C1)C(C)(F)F CN(CC(=O)N1C[C@@H1]2C(CNC(=O)C3=CCCOCC3)[C@H1]2C1)C4CC4 COCC1(NC(=O)[C@H1](F)N2C=CN=C2)CCN(C(=O)CC3CC3)CC1 C=CC[C@]1(NC(=O)C=2N=NSC=2C)CCN(C(=O)CCCN3C=NC=N3)C1 C=C[C@H1](C)CC(=O)NC1(CC(=O)N[C@H1]2CC(=O)N(CC)C2)CCC1 CO[C@@H1]1C[C@@H1](O)CN(S(=O)(=O)C2=CC=C(NCCCCC3=CN=C[NH1]3)C=C2Br)C1 CC(C)[C@H1](CC(=O)N1CCC[C@H1]1CNC(=O)CC2=CC=CO2)C3=CC=CC=C3 CCOC=1C=C(C(=O)N[C@@H1](C)CN(C)C(=O)C=2[NH1]C(C)=C(C(C)=O)C=2C)ON=1 O=C(N[C@H1](CO)CNC(=O)[C@]1(F)CCN(C(F)(F)F)C1)C=2C=NSC=2 CC[C@@](C)(CNC(=O)C1=CSN=C1C2=CC=CC=C2)C(=O)OC COCCCNC(=O)[C@H1](C1=NC=C(Br)S1)N(C)CC2=NC(CCOC)=NO2 CC1=CN=C(CCC(=O)N[C@H1](CCNC(=O)[C@H1](C)C(C)(F)F)C(C)C)[NH1]1 O=C(N[C@H1]1CCN(C(=O)CSC2=CC=CC(F)=C2)C[C@H1]1CO)C3=C[NH1]C(=O)C=N3 CN(CC1CN(C(=O)[C@H1]2C[C@H1](O)C2)C1)S(C)(=O)=O NCCOCCOCCNC(=O)CC1=CC=C(C2=CC=CC=C2)C=C1 CC1=NC(C)=C(C(=O)N2C[C@@H1]3C[C@H1](C2)N3C(=O)C4=C(F)C=C(Cl)C=C4Cl)S1 COCCN(C)CC(=O)N[C@@H1]1CCO[C@H1]1C2CCN(C(=O)C3=CN=C(S)[NH1]3)CC2 CCN(C(=O)C1=CC=2SC=CC=2N1C)[C@@H1]3CCN(C(=O)CC4CC(C)C4)C3 CS[C@@H1](C)C(=O)N1CCN(C(=O)C2=CC(C)=CC3=CC=CN=C23)CC1 CC=C(C)C(=O)N1CC[C@H1](CN(C)C(=O)CSC2=NN=NN2CC(F)(F)F)C1 CCCOCCCC(=O)N1CC[C@H1](CNC(=O)CCCCC(C)C)C(F)(F)CC1 CCCC=CC(=O)NC1(C)CCN(C(=O)CN2C[C@H1]3CC[C@H1]2C3)CC1 CC1=CSC([C@@H1](C)CN[C@@H1](C2=CN=C(C(C)(C)C)O2)C3=NN=NN3C(C)(C)C)=N1 CC(C)C1=NC(CC(=O)N[C@@H1]2CCCN(C(=O)CN3N=CC(C#N)=C3N)C2)=CS1 C[C@H1]1CN2CCC[C@@H1]2CN1S(=O)(=O)C3=CC(Cl)=CC=C3CS(C)(=O)=O CCNC(=O)CCCC(=O)N1CC[C@]2(C[C@@H1]2NC(=O)C3=C(CC)OCCC3)C1 CC1(CN=C2[NH1]C3=C(C(=NCCCCC4=NC=C[NH1]4)[NH1]2)SCC3)C[C@@H1]5C[C@H1]5C1 CC(=O)C1=CC=C(C(=O)N2CCC[C@](C)(NC(=O)C[C@H1]3CCCOCC3)C2)C=C1 C=C1CC1C(=O)N2C[C@H1]3CC[C@H1]2CN3C(=O)COC4=CC=C(CO)C=C4 CC(C)CC[C@H1](O)C(=O)NC1([C@H1]2CCN(C(=O)C#CC3CC3)C2)CC1 CC=CC=CC(=O)N(C)C[C@H1](O)CN(C)C(=O)CCC1=NC=CC=N1 CC1=CC(F)=CC=C1NC(=O)[C@H1](CC2(C)CC2)N3C[C@@H1]4CC[C@H1](C3)C4O CS[C@H1](C)CCNC(=O)[C@H1]1CCN(C(=O)C2=CC=CC3=C[NH1]N=C23)[C@@H1](C)C1 CC(C)(C)C[C@H1](CO)CNC(=O)NC1=NC(C2CC2)=N[NH1]1 O=C(NC1CCC(NC(=O)[C@@H1]2C[C@@H1]3COCCN3C2)CC1)C4=CC([N+1](=O)[O-1])=C[NH1]4 CC(=O)C1=NC=C(C(=O)N2CCC[C@@H1](N(C)C(=O)C[C@@H1](O)CN(C)C)CC2)S1 CC[C@H1](CN(C)C)C(=O)N1CC[C@@H1](CC(=O)N2CC[C@H1](OC3CC3)C2)C1 C[C@@H1](C(=O)OC(C)(C)C)C(=O)N1CCC[C@](C)(CNC(=O)C(F)=CC2CC2)C1 C=C(C)C1=CC=CC=C1NC(=O)C[C@@H1]2CCN2C(=O)[C@H1](C)C#N CC=CCCC(=O)N1CCN(C(=O)CNC(=O)CCC2=NC(C)=NO2)CC1 COC1CC2(C1)CC(C(=O)N3CC[C@H1]4CC[C@@]43CNC(=O)C(C)(C)C(F)F)C2 C=CCNC(=O)[C@H1](C1=CSC(C(F)(F)F)=C1)N2CCC(F)(F)[C@H1](CO)C2 C[C@H1](CF)C(=O)N[C@H1]1CC[C@@]2(CC1)CN(C(=O)C=3C=C(C(F)F)[NH1]N=3)CCO2 O=C(N[C@H1]1CO[C@@H1](C(F)F)C1)[C@]2(F)CC3CCC2CC3 CC(=O)NCCC1(C(=O)NC[C@@]2(C)COC(=O)C2)CCCC1 CC1(C)[C@H1](NC(=O)[C@@H1]2CCCN([C@H1](C)CN3CCCCC3)C2)[C@@H1]CCCO[C@H1]1C CCC1CC(C(=O)N2CC3C(CCN(C(=O)C[C@H1](C)C=4C(C)=NOC=4C)C3)C2)C1 COC1=CC=2C=C[NH1]C=2C=C1C(=O)NC[C@@]34C[C@@H1]3CN(S(=O)(=O)C=5C=CN(C)N=5)C4 CN1CC[C@@H1](CN(C)[C@H1](C(=O)NCC2CC2)C3=CC(C(F)(F)F)=CC=C3Br)C1 CC(C)C[C@@H1](C)C(=O)N1CCC[C@H1](N(C)C(=O)COC=2C=NN(C)C=2)C1 CO[C@H1](C)C(=O)NCCOC1CN(C(=O)C2=CC=NN2C(C)C)C1 CCC[C@H1](O)CNC(=O)[C@H1]1CCN(C(=O)[C@@H1]2CC[C@H1](CC)O2)CCO1 COC1=CC=C(CC(=O)N2C[C@H1](NC(=O)CCCC(C)(F)F)[C@@H1](C3CC3)C2)N=C1 CO[C@@H1](C(=O)NC[C@H1](C(=O)N1CCC[C@H1](F)C1)C(C)(C)C)C2CCCC2 CCC1=C(F)C=CC=C1C(=O)N[C@H1]2C[C@@H1](NC(=O)[C@]3(F)CCOC3)C2 COCCN1C=CC(C(=O)NCCCNC(=O)CCC2=CN=C(O)[NH1]2)=N1 CCO[C@H1](CC)C(=O)N1CC[C@@H1](C)[C@@H1](NC(=O)CCNC(=O)C2=CC=CS2)C1 O=C(C[C@@H1]1CC[C@H1](O)C1)N2CC[C@@](CO)(C(=O)NC[C@@H1]3CC4=CC=CC=C43)C2 CC1=NOC=C1C(=O)NC[C@H1]2CCN(C(=O)[C@@H1](CC(C)C)N(C)C)CC2(F)F C=CCCO[C@H1](C)C(=O)N1CCN(C(=O)CCSCC)[C@@H1](C=2C=N[NH1]C=2)C1 CC1(C)CO[C@H1](C(=O)N2C[C@@H1]3C[C@@]3(CNC(=O)C4=NC=C5C=CC=CN45)C2)CO1 CC[S@](=O)CC(=O)NCCN1C=C(CNC(=O)C2CC3(C2)NC(=O)NC3=O)N=N1 COCCOCCOCCCC(=O)N[C@H1]1C[C@H1](C)CN(C(=O)C=C(C)Cl)C1 C=C(Br)CC(=O)N1CC[C@H1](NC(=O)C2=CC=C(N)C=C2F)C1 CC(C)CC(=O)NC1(C2=CC=CC=C2)CCN(C(=O)C[C@@H1]3CCO[C@@H1]3C)CC1 C[C@H1](C(=O)NCC12COC(CNC(=O)CN3C=NC4=C3CCCC4)(C1)C2)[C@@H1](C)O COC[C@H1](NC(C)=O)C(=O)NCCC1(CNC(=O)[C@@H1](C)OCC(F)(F)F)CC1 CC=1C=CN([C@@H1](C)C(=O)N(CCO)[C@H1]2CCCN(C(=O)C3=CN=C(C)[NH1]3)C2)N=1 C#CC[C@@H1](C(=O)N1C[C@H1](NC(=O)C=2C=C(C3CCC3)ON=2)CC[C@H1]1C)C4CC4 CC(=C(F)C(=O)N(C)C[C@@H1]1CN(C(=O)CC2=CC(C)=CC(C)=C2)CCO1)C3CC3 OC1=CN=C2C=CC=CC2=C1CN[C@H1](CO)CC3=CC=C(Cl)C=C3Cl CCC1=NC(=N)[NH1]C(=N[C@@H1]2CCN(C(=O)[C@H1]3CCCO[C@H1]3C)CCC2(F)F)[NH1]1 C=C(Cl)CCC(=O)N1CCC[C@H1]1C2(NC(=O)C3=CC=C(N4CCC4)N=C3)CC2 CO[C@H1](C(=O)N1CCC(NC(=O)C2(C)SCCCS2)CC1)[C@H1]3CCOC3 CC(C)(C)[C@H1](C(=O)NCC[C@@H1]1CN(C(=O)COC2(C)CCC2)C[C@H1]1O)C3CCC3 C[C@@H1](C(=O)NC[C@H1](O)CN(C)C(=O)CN=S(C)(C)=O)C1=CC2=CC=CC=C2O1 CCSCC1=CC(C(=O)N[C@H1]2CCN(CC3=CSC=C3Br)CC2(C)C)=NO1 CC(=O)C1=NC(C(=O)NC2(C)CC(NC(=O)CCSC3=CC=CC=N3)C2)=CS1 CC(=CC(=O)N[C@@H1]1CN(C(=O)C2=CN=NC(C)=C2C)CC[C@@H1]1C)C(C)C CCCC1=NC(C)=C(C(=O)N2CCC=3SC=CC=3[C@@H1]2CNC(=O)[C@H1]4[C@@H1](C)[C@H1]4C)O1 COC1=CC=C(C(=O)N[C@H1]2CCCC[C@@H1]2CN=C3[NH1]N=C(C(N)=O)S3)C(C)=C1 C[C@](CNC(=O)CO[C@@H1]1CCOC1)(NC(=O)C2=CC=C3OC=CC3=N2)C4CCC4 CCC[C@H1]1C[C@@H1]1NC(=O)CCOCCCNC(=O)C2=CC=C(C)C(C)=C2 CC(=O)N(C)[C@@H1](C)C(=O)N[C@@H1](C)C1CN(C(=O)C2=CC=CC(=O)N2C)C1 C=CC[C@@H1](CNC(=O)[C@H1](CC#CC)NC(=O)CNC(=O)CC(C)C)CC(C)C CCSC1=CC(CN[C@H1]2CC[C@@H1](C(C)(C)C)CC2)=CC(C(=O)OC)=C1 C=CCC(=O)NCCC(CC)(CC)NC(=O)C1=CNS(=O)(=O)N=C1C C#CCC[C@@](C)(NCC=1C=CN2N=NN=C2C=1)C3=NN=NN3CCCOC CC[C@H1](C)[C@@H1](C)CNC(=O)CC(C)(C)CNC(=O)[C@H1](C)N1C=NN=N1 CSCC[C@H1](NC(N)=O)C(=O)N[C@@H1](C)CN(C)C(=O)[C@H1](C)CC(=O)OC CC1=CC=C(C(=O)NC[C@]2(C)CC[C@@H1](NC(=O)CC=3C=CN(C)N=3)C2)C=C1C#N CCN1N=NC=C1C(=O)N[C@@H1](C(=O)N2CCN3C(C)=NN=C3C2)C(C)C COC1=CC=CC(CN2N=NN=C2[C@H1](NCC=3C=C(Cl)SC=3Cl)C4(OC)CCCC4)=C1 CC[C@]1(C)CCN(C(=O)C[C@@]2(C)CCN(C(=O)[C@@H1]3CCC[C@H1]3OC)C2)C1 O=C(CCC1=NN=CS1)N2C[C@@H1]3CC[C@@]3(CC(=O)N4CC[C@H1]4CO)C2 COC1=NC=C(C(=O)NC[C@@H1]2C[C@H1]2NC(=O)C[C@@H1]3CC4=CC=CC=C4O3)C=C1C O=C(NC[C@@H1]1CCCC2=NC=CN21)C(=O)NC3=CC=C([N+1](=O)[O-1])C=C3 CCN1C=NC(C(=O)N[C@@H1]2CCN(C(=O)CC3=CC(O)=NN=C3O)C[C@@H1]2CC)=N1 CC1=C[NH1]C(C(=O)N2CCN(C(=O)C3=CC=C([N+1](=O)[O-1])O3)[C@@H1](C)[C@H1]2C)=C1C CC1=CN2C=C(C(=O)N[C@H1]3CCN(C(=O)CC4=CC=CO4)C[C@@H1]3C)SC2=N1 C#C[C@H1]1[C@@H1](C(=O)N(C)[C@@H1]2CCN(C(=O)CNC(=O)C3=CC=CC(F)=C3)C2)C1(C)C COC1=C(C(=O)N[C@]2(C)C[C@@H1](NC(=O)CN3N=CC(Br)=N3)C2)C=NN1C C[C@@H1]1CCN(C(=O)C2=CN3C=CSC3=N2)[C@H1](C(=O)O)C1 CC=1N=C([C@@H1](C)N)SC=1C(=O)NC[C@H1]2COC3=CC=CC=C32 CO[C@H1](CNC(=O)[C@H1](CN1C=NC=N1)NC(=O)CN2CSCC2=O)C(C)(C)C CO[C@H1](CC(C)C)C(=O)NC[C@H1]1[C@@H1]2C[C@H1]1CN2C(=O)C3=CC=C(C(N)=O)[NH1]3 CN(C(=O)C1=NC=CC(Cl)=C1F)[C@@H1]2CC[C@@H1](NC(=O)CCOC3CC3)C2 CCC1(CN(C=O)[C@@H1]2CCO[C@H1](C)C2)CCN(C(=O)OC(C)(C)C)CC1 CNC(=O)CCN(C)C(=O)[C@@H1]1C=CCN1C(=O)C=2[NH1]C=C(C)C=2C C[C@@H1](NC(=O)CCCCN1C=C([C@](C)(O)C(=O)O)N=N1)C2=CC(O)=N[NH1]2 C[C@H1](NC(=O)C1=C[NH1]C(C#N)=C1)[C@@H1]2CCN(C(=O)C3=NC4=C(S3)CCCC4)C2 CC[C@H1]1CCC[C@H1]1C(=O)NC2(CNC(=O)C3=CSC(C4=CN=C[NH1]4)=N3)CC2 CC1=NC([C@H1](C(=O)NC2CCOCC2)N3CCC(C(C)(C)C#N)CC3)=N[NH1]1 COC=1C=C(C(=O)N2CCC[C@H1]2[C@H1](C)NC(=O)C=CC=3C=N[NH1]C=3)SC=1Cl CC1=CC=CC(C(=O)NC2CC(F)(CNC(=O)C3CCC(CCO)CC3)C2)=N1 CC(=CC(=O)N[C@H1]1C[C@@H1](C)N(C(=O)C2=CCC2)C1)C3=CC=CC=C3F O=C(COC1=CC=CC(F)=C1)NC[C@@H1](CO)NC(=O)CC2=CC=C3C=COC3=C2 O=C(C1=CC=CN1C2CCCC2)N3CC4(CCN(C(=O)[C@H1]5CC56CCC6)CC4)C3 CC[C@H1](C)[C@H1](O)C(=O)N1CCC[C@H1](NC(=O)C=2SC(S(N)(=O)=O)=C(C)C=2Cl)[C@@H1]1C C[C@@H1]1C[C@H1](NC(=O)CCSCC(N)=O)CCN1C(=O)C2=CN=CC(S(C)(=O)=O)=C2 O=C(C=1C=NN2C=C[NH1]C=12)N3CCC[C@@H1](N=C4[NH1]C(Cl)=NC5=CC=C(Cl)N=C45)C3 CCC1=NOC(CC(=O)NC[C@@]2(C)CCCN(C(=O)C(C)=CC=3C=N[NH1]C=3)C2)=N1 CC(C)NC(=NCCC1=CN=NN1C)N[C@H1]2CCC2(C)C C[C@@]1(CNC(=O)CC2=CC=C(Cl)N=C2)CC(F)(F)CN1C(=O)CCCNC(N)=O COC1=CN=C(C(=O)NC[C@H1]2CC[C@H1](NC(=O)C3=C[NH1]C(C#N)=C3)C2)N=C1 CC1=NOC(COCC(=O)N(C)[C@H1](CNC(=O)C(C)(C)N(C)C)C2CC2)=N1 C#CCCCCC(=O)N1C[C@@H1](NC(=O)C=2SC=CC=2Cl)CC[C@@H1](O)C1 CC[C@@H1](C)CCC(=O)NC[C@@H1]1CN(C(=O)C2=COC3=C2CCCC3)CC(C)(C)C1 CC1=C(C(=O)N2[C@H1]3CC[C@@H1]2C[C@H1](NC(=O)[C@H1](F)CC4CC4)C3)[NH1]C5=CC=CC=C15 CCCCC(=O)C(=O)N1CC[C@@]2(NC(=O)C=3ON=C4C=CC=CC=34)CCC[C@H1]12 C#CCC1(C(=O)N2CC[C@H1]([C@H1](F)C(=O)N(C)CCC(=C)C)C2)CCC1 COCC[C@H1]1CN(C(=O)C2=C(C)CCC2)CCN1C(=O)[C@H1](C)C=3C(C)=N[NH1]C=3C CC1=CSC(Cl)=C1C(=O)NC[C@@]2(CNC(=O)[C@H1]3CC[C@H1]3C)CC2(F)F COC1=CC(N(CC2=CC=NN2C(C)(C)C)[C@@H1]3CNCCC34CCC4)=NC(C)=N1 COC(=O)C1=CC=C(OC)C(NS(=O)(=O)CCC2=CC=CC=C2OC)=C1 C=C1C[C@@H1](C(=O)NCC2(CO)CCN(C(=O)C3=CN(CCC)N=C3C)CC2)CC1 COC(=O)[C@H1]1CC[C@H1](C(=O)N2CC(CNC(=O)C=3C(C(C)(C)C)=NSC=3N)C2)C1 CO[C@@H1]1C[C@H1](CNC(=O)CN2C=CC(C)=CC2=O)N(C(=O)C3=CN=CC=C3Cl)C1 CC1(C)CC(CC(=O)N(CCNC(=O)CC[C@H1]2CCCCN2C)C3CCCC3)C1 CCC[C@H1](CC(=O)N[C@@]1(CCC)CCOC1)NC(=O)C=2C=C(O)N(C)N=2 C[C@H1](C(=O)N[C@@H1]1CCN(C(=O)CN2N=NC3=CC=CC=C32)C1(C)C)S(N)(=O)=O CSC1(C(=O)N(C)CCCOCCNC(=O)[C@@H1]2CNC(=O)N2)CC1 CS[C@@H1](C(=O)NC[C@@H1]1CCCN1C(=O)C=2SC(CO)=NC=2C)C3=CC=CC=C3 COCC[C@@H1](OC)C(=O)N1CCC[C@H1]1/C=C/C(=O)N(C)CC2=NC(C)=NO2 CC(C)C[C@@H1](NC(=O)CC(Cl)Cl)C(=O)NC[C@@]1(C)C[C@H1]2CC[C@H1]1C2 CC[C@H1]1CC[C@H1](C(=O)NC[C@@H1](O)CCNC(=O)C2[C@H1]3CC(=O)C[C@H1]23)CC1 C=CCC[C@H1]1CCCN1C(=O)[C@@H1](CNC(=O)C=2C=CC(=N)[NH1]C=2)CC3CCCC3 CCC1=CC(C)=CC=C1C(=O)N[C@@H1]2CN(C(=O)[C@@H1]3CCN3C4CCCC4)C[C@@H1]2O CC1=CN=C(CC(=O)NC[C@@]23C[C@@H1](CO2)N(C4=NC=NC=5ON=C(C)C4=5)C3)S1 O=C(CC1CCCCC1)N[C@@H1]2CCCN(C(=O)[C@@H1]3CC3(Cl)Cl)C2=O CN(CCCCC(=O)NC=1ON=CC=1C=2N=N[NH1]N=2)C(=O)OC(C)(C)C C[C@@H1](CC1CC1)N(C)C(=O)[C@@]2(CNC(=O)C3=CSC(Cl)=N3)CCCO2 CNC1C[C@H1](C(=O)N2CCC(OCCNC(=O)C3(O)CC4(CCOCC4)C3)CC2)C1 CC[C@H1](CC(=O)NC[C@@H1](NC(=O)C1=C(OC)C=CC(OC)=C1N)C2CC2)SC CCN1C[C@H1](C(=O)NC(C)(C)CCNC(=O)C2=CC(C)=C(Cl)C(N)=C2)NC1=O C[C@@H1](CSCC1=CC=CN=C1)C(=O)NCCC2(NC(=O)[C@@H1]3C[C@H1]3C4CCC4)CC2 CC1=CON=C1CC(=O)N2CC(NC(=O)CC3=CC=C(C4=CSC(C)=N4)C=C3)C2 CC12CCN(CC1)C[C@H1]2NC(=O)[C@@H1]3COCCN(C(=O)[C@@H1]4C[C@H1]5C[C@@H1]4CC5=O)C3 CC[C@H1](C)[C@@H1](CC(=O)NCC1=NC(C)=CO1)NC(=O)C(C)(CC)CC CC(=O)N(C)CC(=O)NC1CC(O)(CNC(=O)C[C@@H1]2CCN(C)C2=O)C1 C[C@](CNC(=O)C=1SC=CC=1C#N)(NC(=O)C[C@@H1]2OCCC=3SC=CC=32)C4CC4 CO[C@]1(C(F)F)C[C@H1](C(=O)N2CCC3(CC2)C[C@H1]3CNC(=O)C=4C=C(CO)[NH1]N=4)C1 ClC1=NC=CC=C1/C=C/CN2C[C@@H1]3CC[C@H1](C2)[C@@H1]3N4CCC[C@@H1]4C5=CC=NC=C5 C=CC=CCC(=O)N[C@@]12CCN(C(=O)C=CC3=C[NH1]C(=N)C(C)=C3)C[C@@H1]1C2 CCCC[C@H1](O)C(=O)N[C@@H1](C)[C@H1]1CCCN1C(=O)C2=CC=C(O)C(Br)=C2 CCN1C=CC(CC(=O)N[C@H1](C(=O)N2CCC23CCCC3)C4(O)CCC4)=N1 C[S@](=O)C1=C(Cl)C=CC=C1NC(=O)C(=O)N2CCC[C@@](C)(C(=O)O)C2 CCOCCC(=O)N[C@H1]1COC[C@H1]1C(=O)NCC2=CC(Cl)=NO2 CCC1CN(C(=O)CC2=CN=CC(F)=C2)CCN1C(=O)C3=CN=CN3C CC(C)N(C)C(=O)[C@@H1]1CC2(CC2)CN1C(=O)COCCF CCOC1=CC=CC=C1[C@@H1](CC)N[C@@]2(C3=NN=NN3C)CCCC(C)(C)CC2 C[S@](=O)[C@@H1]1CCC[C@@H1](NCC2=CC=C(Cl)C(C(F)(F)F)=C2)C1 CN(CC(C)(C)NC(=O)C[C@@H1]1COC2CC1C2)C(=O)C3=CC4=CC(Cl)=CN=C4O3 CCOC[C@H1](O)CNC(=O)[C@@]1(NC(=O)[C@H1]2CCOC2)CCN(C)C1 COC[C@H1](O)C(=O)N1CCOC[C@]12COCCN(C(=O)[C@H1]3CC[C@@H1](C)O3)C2 C[C@H1](CCN=C1N=C(CO)C=C[NH1]1)NC(=O)[C@H1]2C[C@@H1]2C3=CC=CC=C3 CC1=COC=C1C(=O)N[C@@H1]2[C@@H1](C)CN(C(=O)C3=CC(C)=C(C(F)F)C=N3)C[C@H1]2C CN1C=C(C(=O)NC2CCN(C(=O)C3=CSC4=CC=NC=C34)CC2)C(C5CC5)=N1 C[C@@H1](NC(=O)[C@H1]1CSC2=CC=CC=C21)C3CCN(C(=O)C(=O)NCC(F)F)CC3 C=CC(C)(C)CC(=O)N[C@H1](C)CCNC(=O)[C@@H1]1C[C@@H1]2CS(=O)(=O)C[C@@H1]2C1 CC1=C(O)C=CC=C1CN2CCN3C(=O)[C@H1](NC(=O)C4=CC=CC=C4)C[C@@H1]3C2 CC1=CC=C([C@@H1](C)C(=O)N2CCC[C@@H1](N3C=C(C=4C=C[NH1]C(=N)C=4)N=N3)C2)O1 C[C@H1](CNC(=O)C1=CC=CC(N)=N1)N(C)C(=O)[C@H1]2C[C@](F)(CO)C2 CCOC1=CC=CC=C1C=CC(=O)NC[C@]2(O)CCN(C(=O)C3=C[NH1]C(=N)O3)C2 O=S(=O)(C1=CC=C(N2CC[C@@H1](OC3CC3)C2)C(F)=C1)N4C[C@@H1](O)C5(CCCC5)C4 CC(C)C[C@H1]1CN(C(=O)C2=NN(C)N=C2C(F)(F)F)CCO1 C[C@@H1]1O[C@@]2(C(=O)N3CCOC4(C3)CN(C(=O)C5(C#N)CCC5)C4)CC[C@H1]1C2 O=C(CC12CCCN1CCC2)N[C@@H1]3C[C@H1]4CC[C@H1]3N(C(=O)[C@@H1]5CCCOC5)C4 C[C@@H1](C(=O)N[C@H1]1C[C@H1](NC(=O)C2=CC=C3C=CN=CC3=N2)C1)N4CCCCC4=O CC=1N=C2C=CC=CN2C=1CN3CCN(S(=O)(=O)C4=CC=CC=C4F)CC3 C[C@H1]1CC[C@@H1](CC(=O)N(C)C[C@@H1]2C[C@H1](F)CN2C(=O)CN3CCCCCC3=O)C1 C[C@H1](O)[C@@H1](NC(=O)[C@@H1]1COC2=CC=CC=C2C1)C3=CC=CC=C3F CCCCCC[C@@H1](C)NC(=O)[C@@H1]1CCC(C)(C)N(C(=O)C=2C(C)=NOC=2CC)C1 CC(=O)N1CC[C@@H1](CN(C)C(=O)C2=CN3C=CC=C(Br)C3=N2)C1 CC=1SC(C)=C(C(=O)NCCCC[C@H1](C)NC(=O)[C@@H1](C)CCN(C)C)C=1C#N CC=1C=C(CC(=O)OCC2=CC=C(C#N)C=C2)SN=1 C[C@H1](CN(C)C(=O)[C@@H1](O)C1CCCCCC1)NC(=O)C=2C=C3N(N=2)CCO3 CC(C)C(C(=O)N1CCC2(CC1)CN(C(=O)[C@H1](C)C3CCCC3)C2)C(C)C COCC1=CC=C(C(=O)NCC[C@@H1](C)N(C)C(=O)[C@@H1]2CN(C(C)=O)CCO2)C=C1 C[C@@H1]1CCC=C1C(=O)N[C@@H1](C(=O)NCCN2CCC(O)CC2)C=3C=COC=3 CN(C)C(C)(C)C(=O)N1CCC(CCC2CCN(C(=O)C3(Cl)CCC3)CC2)CC1 CC[C@H1](CC(=O)NCC=1C=COC=1C(=O)N(C)[C@@H1]2CCC[C@@H1](C)[C@@H1]2C)OC C=C[C@@](C)(CC)NC(=O)[C@H1](C)CN(C)C(=O)CN1C=CN=N1 C[C@@](O)(CNC(=O)[C@@H1]1CCCO1)C2CCN(C(=O)/C=C/C3CCCCC3)CC2 CC[C@@H1](CC(=O)N(C)C[C@@H1]1CCCCN1C(=O)C2=NC=NC(OC)=C2F)C(F)F CC=1C=C(C(=O)N2CCCC[C@]23C[C@H1](NC(=O)C4=CC=CN(C)C4=O)C3)SC=1Cl CC(C)N(CCF)[C@H1](C(=O)NCCC1=CC=CC(F)=C1)C2=CC(Cl)=NC=C2F CC1=NC=C([C@H1](C)NS(=O)(=O)C2=CN=C(N[C@H1]3C[C@@H1](OC(C)(C)C)C3)C=C2C)S1 C[C@@H1]1CCC[C@H1]1CC(=O)N(C)C2C[C@@H1]3CC[C@H1](C2)N3C(=O)CCC(C)(C)F CC1=CN=C(C(=O)NC2CC(F)(CNC(=O)C(C)(C)C3=CC=CS3)C2)C=C1Cl CC1=CC=CC(C)=C1C(=O)N2CC[C@@](C)(CCNC(=O)COC3CCCCC3)C2 COCN1C=CC(C(=O)N2CC(NC(=O)C[C@@H1]3CO[C@H1](C(F)(F)F)C3)C2)=N1 C=C1CN2C(=NN=C2C(=O)NCC[C@H1](C)NC(=O)C3=NC=C([N+1](=O)[O-1])N3C)S1 CC[C@H1](C)N1N=C(C2CCN(C(C)=O)CC2)N=C1C=3N=COC=3C(F)(F)F CP(C)(=O)C1=CC=CC(CN=C(NCCF)NC[C@@H1]2CCOC[C@@H1]2C)=C1 CC(=O)C1=CSC(C(=O)NC[C@H1]2C[C@@H1]2CNC(=O)CCCC(F)(F)CO)=C1 C[C@H1]1CC[C@@H1](NC(=O)NC2CCC3(CC2)CC(C(=O)O)CO3)CC4=CC=CC=C41 CC1=NC=C(Cl)C=C1C(=O)NC[C@@H1]2[C@H1]3C[C@H1]3CN2C(=O)C4CN(S(=O)(=O)N(C)C)C4 CC1(C)[C@H1]2C[C@H1](C(=O)NCCCC=3[NH1]C(=N)[NH1]C(=NCC4(C5CC5)CC4)N=3)C[C@H1]21 COC(=O)[C@]1(C(=O)OCC(=O)C2=CC=C(Cl)C=N2)[C@@H1]3CC4=CC=CC=C4[C@@H1]31 CCC=CC=CC(=O)N[C@@H1](C)C1(O)CN(C2=C(Cl)C=CC=C2[N+1](=O)[O-1])C1 CN(CC1=CC=CN=C1O)C(=O)[C@H1]2C[C@H1]2CNC(=O)CC3(O)CCCC3 O=C(NC1(CCO)CN(C(=O)C2=CC=CC=3N=C(O)OC2=3)C1)[C@H1]4CC4(Cl)Cl CC1=CC=NC=C1C(=O)N2CCN(C)[C@H1](CNC(=O)C3=COCCO3)C2 C=C[C@H1](O)C(=O)N[C@@]1(CNC(=O)CC2=NOC=C2C)CC3CCC1CC3 CN(C)[C@H1](CO)C(=O)NC[C@@]12C[C@@H1](CO1)N(C(=O)C=3C=C(C4CC4)ON=3)C2 CCN1C=CC(CC(=O)N2C[C@H1](CC(=O)NOC3CCN(C)CC3)C[C@H1]2C)=N1 CC(C)[C@](C)(O)CNC(=O)CCCN(C)C(=O)CCS(N)(=O)=O CCN(CCO)C(=O)C1=CSC([C@H1]2CCCN2C(=O)[C@@H1](N)CC(F)F)=N1 C=CCC1(NC(=O)[C@@H1](C)CC2=CC=CC=C2F)CN(C(=O)C=CCC)C1 C[C@H1](C(=O)NCC1=CC=CC(N2C=CN=N2)=C1)N3C=C(CCN(C)C)N=N3 CC=1C=C(C(=O)NC[C@@](C)(CC)NC(=O)C[C@H1]2CCCS2(=O)=O)N(C3CCC3)N=1 CC(C)C1=CC(C(=O)N2CC[C@@](C)(C(=O)N=C3C=NN(C)[NH1]3)C2)=NO1 C[C@H1](CC(=O)N1CCSC[C@@H1]1C(=O)NC2=CC=C(C(F)(F)F)C=C2O)C(C)(C)C CC1(CCN2N=NN=C2[C@@H1](NCCN3C=NC4=CC=CC=C43)C5=CN=C(Cl)S5)CC1 CO[C@@H1]1C[C@H1](CNC(=O)C=2C=NN(C)C=2)N(C(=O)C3=CC=CC(N)=C3O)C1 CC1=CC=C(C(=O)N2CCC[C@@H1]2/C=C/C(=O)N3CCCNC(=O)[C@@H1]3CC)C=C1C CC(C)C1C(=O)N(CC(=O)N2C[C@@H1]3CN(C4=CC=NC(C(F)(F)F)=N4)CC[C@H1]3C2)O1 CN(C)CC1=CC=C(C(=O)NC[C@]23CC[C@H1]2CN(C(=O)[C@H1]4CCCCO4)C3)C=N1 C#CCCCCCC(=O)N1CC(C)(C)OC[C@H1]1CNC(=O)CN2C=C(C)C=N2 CCC1=CC(C(=O)NCCN(C(=O)C2=COC3=C(F)C=CC=C23)C(C)C)=CC=N1 CCC(=O)N1CCCC[C@@H1]1C(=O)N[C@H1](C)C2=CN(C)N=C2C(C)C C[C@@H1]1C[C@H1](C(N)=O)CN(C(=O)C2(C3CC3)CN(C(=O)C(F)=C4CCCCC4)C2)C1 C[C@@H1](CC(F)(F)F)NC1=NC2=CC=CC=C2N=C1N3CCC[C@H1](CC#N)C3 CCCN1C[C@@H1](C(=O)N2CCC[C@@H1]2C3=NC=CS3)CC1=O C[C@@H1]1CN(C(=O)[C@@H1](O)CC2=CN=C[NH1]2)C[C@H1]1CNC(=O)CCC3=CC=CC=C3O CC(C)[C@H1]1N(C(=O)[C@H1]2C=CCN2C(=O)CCCC3CC3)CC1(C)C C[C@@H1](C(=O)NC[C@H1](CO)CNC(=O)C1=CC(=O)N2C=CC=CC2=N1)S(C)(=O)=O COC1=CC=CC=C1[C@]2(C)C[C@H1]2NC(=O)NC3=CC=NN3C(C)C O=C(N[C@H1]1C[C@H1](C(=O)N2CC=CCO2)C1)C3=CC=NN3C4=CC=CC=C4 C[C@@H1]1C[C@@H1]1CN(C)C(=O)C=CC=CCNC(=O)[C@@H1]2[C@H1]3CN(C)C[C@H1]32 CC1(C#CC(=O)N2CC[C@@H1]3CCC[C@]32CNC(=O)C4=CC=C(N)C=C4Cl)CC1 COCCO[C@H1](C)C(=O)NC[C@H1]1CC[C@H1](NC(=O)C=2C=CN(C)N=2)CC1 CC1=CC=C(C(=O)N2CC[C@]3(C(=O)N[C@H1](C)CC(C)(C)C)CCC[C@H1]23)N=C1O C=C(C)CCCC(=O)NC1CCC(CC(=O)N[C@@H1]2CCC[C@@H1]2C)CC1 COCCCC(C)(C)C(=O)N1C[C@@H1]2C[C@H1](C1)CN2C(=O)[C@@H1]3CCCCNC3=O C#CCCCC(=O)NC[C@@H1]1C[C@H1]2CN(C(=O)[C@H1]3CCN4C=NC=C4C3)C[C@@H1]12 CNC1=CC(C(C)(C)C(=O)N2CC3(CCN(C(=O)CN4CC[C@@](C)(O)C4)CC3)C2)=N1 CCC1=CC(C(=O)N2C[C@@H1](NC(=O)C3(S(N)(=O)=O)CC3)CC24CCCCC4)=N[NH1]1 C1NCC[C@@H1]1N=C[NH1]C(=NC[C@@H1]2CCCCS2(=O)=O)C3=CC(C(F)(F)F)=CC=C3[NH1] COC(=O)[C@@H1](C)NC(=O)[C@@H1](C)N(CCNC(=O)CC1(OC)CC1)C2CC2 C#CCNC(=O)CC(=O)N1CCCC(C)(C)[C@@H1]1C(=O)N2CC[C@H1](N3C=CC=N3)C2 C=CC1(CC(=O)N(C)CCCCCNC(=O)[C@@H1]2CSCC(=O)N2)CCOCC1 CC1=CC=C2OC(C(=O)N[C@@H1]3C[C@H1]3CNC(=O)C4(O)CCOCC4)=C(C)C2=C1 CCC[C@@H1](C(=O)N[C@@H1]1C[C@@H1]2C[C@H1](NC(=O)C3(CCOCC)CCC3)C[C@@H1]2C1)C(C)C C=CC[C@@]1(NC(=O)[C@@H1](CCS(C)(=O)=O)OC)CCCN(C(=O)CCC(C)(C)F)C1 O=C(N[C@@H1]1CCCCCN(C(=O)C2=CC=CC=C2)C1)C3=NC=CC=4C=CSC3=4 CN(C)C(=O)C(=O)NC1(C(=O)N[C@H1]2C[C@H1](C)C2)CCCCC1 CCC[C@H1](O)CC(=O)N[C@@H1]1CCC[C@H1]2CN(C(=O)C3=CC=C(C)C(Cl)=C3)C[C@@H1]21 COCC(C)(C)CC(=O)N1CC[C@@](C)(CCNC(=O)[C@@H1]2CC[C@@H1]3C[C@@H1]32)C1 COC1=CC=C2[NH1]C(C(=O)N3CCNC(=O)C[C@@H1]3C(C)C)=CC2=C1 C[C@H1]1CN(C(=O)C2=C(Br)N=NN2C)C[C@H1]1NC(=O)CC3=COC=N3 COC1=CC=C(SCCCC(=O)N2C[C@H1](O)[C@H1](NC(=O)[C@H1](C)CN(C)C)C2)C=C1 CC1=C(C(=O)N2CC(CCNC(=O)[C@H1](C)[C@H1](C)C#C)C2)C=NN1CCC#N CC1=C[NH1]C=C1C(=O)N[C@@H1]2CC[C@H1](N3C=C(CCN(C)C(C)(C)C)N=N3)C2 CC=1C=CC2=NC(C(=O)N[C@H1](C)CNC(=O)C3=CC([N+1](=O)[O-1])=N[NH1]3)=C(N)N2C=1 CCOCCCCC(=O)NC1=CC=C(CCN2C=C(C3=CN=CN=C3)N=N2)C=C1 C[C@@H1](C(=O)NCCOCCOCCCNC(=O)C1=CN=CN=C1)S(N)(=O)=O CC(C)S(=O)(=O)[C@H1](C)C(=O)NC(C)(C)CN(C)C(=O)[C@H1](C)OC1=CC=CC=C1Cl CCN(C)CC(=O)NC1([C@H1]2CCCCN2C(=O)CSC3=NN=CS3)CC1 CCNC(=O)C(C)(C)CNC(=O)[C@H1]1CCCC[C@H1]1NC(=O)C=CC2=CN(C)C=N2 CCOC1CCC(C(=O)N2C[C@H1](C)N(C(=O)C3=C[NH1]N=C3CC)C[C@@H1]2C)CC1 CC(C)NC(=O)CN(C)C1=NC(=N)[NH1]C(=NCC2=CN=C(N(C)C)N=C2)[NH1]1 COC1=CC=CC=C1[C@@H1](OC)C(=O)N2C[C@@H1](C)[C@@H1](NC(=O)CCC=3N=C[NH1]N=3)C2 CC(C)C1=CC(C(=O)N(C)C[C@@H1]2CN(C(=O)C3=CC=C(F)C=C3F)CCO2)=NO1 CC(C)CCC(=O)NC[C@]12CCC[C@H1]1N(C(=O)[C@@]34CC=C[C@@H1](C3)OC4)CCC2 CS(=O)(=O)[C@H1]1C[C@H1](NC(=O)[C@@H1]2C[C@@H1]3CNC[C@H1]2C3)C1 COCCNC(=O)[C@H1](C1=CSC2=CC=CC(F)=C12)N3CCN4C[C@@H1](C)C[C@@H1]4C3 CC[C@H1](C)[C@H1](C(=O)NCC1(C#N)CCCC1)N(C)C(=O)CCC2CC(OC)C2 CN(C)CC(C)(C)CC(=O)N1CCO[C@H1](CNC(=O)[C@H1](F)C2CCOCC2)C1 O=C(NC1(CCNC(=O)[C@H1]2C[C@@H1](O)C2)CCCC1)C3CC(C4=CC=C(Cl)C=C4)C3 CC=1SC=CC=1C(=O)N[C@@H1](C(=O)N[C@@H1](C)C23CC(CO2)C3)C4(O)CCC4 CCCCC1=CC=C(C(=O)N2CC[C@@H1]2CNC(=O)[C@@H1](C)NC(=O)COC)C=C1 CSC(SC)C(=O)N1[C@H1]2CC[C@H1]1CN(C(=O)[C@H1]3CCOC(C)(C)C3)CC2 CC(=CC1=CC=CC=N1)C(=O)N[C@@]2(C)CCN(C(=O)[C@@H1]3CCCN3C(N)=O)C2 CC1=COC(C=CC(=O)NCC[C@H1](C)N(C)C(=O)C2=C(C)C=C(C)C([N+1](=O)[O-1])=C2)=N1 C[C@H1]1CN(C(=O)[C@@H1]2C[C@H1](O)CN2C(N)=O)C[C@H1]1NC(=O)CCC[C@@]3(C)NC(=O)N3 C[C@]1(C(=O)N2CC3(C2)CN(C(=O)[C@@H1]4CCCS4)C[C@H1]3CO)COC5=CC=CC=C51 C[C@@H1](CNC(=O)C1=CC(Cl)=C[NH1]1)N(C)C(=O)[C@H1]2CC[C@H1]3C[C@H1]32 C[C@H1](OC1=CC=CC=C1)C(=O)N2CCO[C@H1](C(=O)NC3=CC=C(Br)C(Br)=C3)C2 CCC1=CC=C(C(=O)NC[C@H1]2CC[C@H1](CNC(=O)OC(C)(C)C)CC2)C(N)=C1 CCN1C=CN=C1C(=O)N(CCNC(=O)C[C@H1]2CCCC=3OC(C)=NC=32)C4CC4 C=CCNC(=O)[C@@H1](C1=CC=C2C=C(C)C=CC2=N1)N3CC[C@H1](C4=NC=CN4C)C3 CC=1C=C(COCC(=O)N[C@H1]2CCCN(C(=O)[C@@H1](C)C3CC3)CC2)ON=1 CCNC(=O)CC(=O)N[C@@H1]1C[C@@H1](O)[C@@H1](CNC(=O)C2=CC=NS2)C1 CC(=O)C=1C=CSC=1C(=O)N(C)C[C@@H1]2CCN(C(=O)C3=NC=NC(O)=C3F)C2 CC[C@@](C)(C(N)=O)C(=O)N(C)C[C@H1](O)CNC(=O)COC1=CC=CC(F)=C1 C#CCC[C@@H1]1CCCN(C(=O)[C@@]2(C)CCCN2C(=O)C3=CC=C(CC)S3)C1 CC[S@@](=O)CC(=O)N1C[C@@H1](NC(=O)C=C2CCC(C)CC2)[C@H1](OC)C1 CC(=O)C1=CC=C(C(=O)NC2[C@H1]3CCN(C(=O)C=CC=C(Cl)Cl)CC[C@H1]3C2)N=N1 CC(C)C=1[NH1]N=C(C(=O)N2CCC[C@@H1](CNC(=O)C[C@@H1](C)F)CC2)C=1Br CCN1C=C(C(=O)N[C@@H1]2CN(C(=O)C=3C=C[NH1]C4=NC=CC=34)C[C@H1]2C)C(C)=N1 C[C@@H1](C1=CC=CC=C1)N(C)C(=O)C(=O)N2CCN3C(=NN=C3CC(F)(F)F)C2 CN(C)[C@@H1](CC1=CC=CC=C1)C(=O)NCC(F)(F)CN2C=C(C3CCC3)N=N2 CSC1=CN=C([C@H1](C(=O)NCCCF)N2CC[C@H1](C3=CC=C(Br)C=C3)C2)S1 CC1=NC(CC(=O)N[C@H1]2COCCN(C(=O)[C@@H1]3COC(=O)N3)C2)=N[NH1]1 CCC(=O)N[C@H1](C)C(=O)N[C@@H1](C)C1CN(C(=O)[C@H1]2CCC3=CC(C)=CC=C3O2)C1 CC1C=CC=C(C(=O)N[C@@H1]2CO[C@H1]3CN(C(=O)C4(N5C=CC=C5)CC4)C[C@@H1]32)[NH1]1 CN1C=C([C@@H1](O)C(=O)N2CC[C@H1](OCC(=O)NC3(C)CCSCC3)C2)C=N1 CC[C@H1](C)CC(=O)N[C@H1]1C[C@@H1](CCNC(=O)CC2=CN=CS2)C1 O=C(C#CC1CCCC1)N[C@H1]2C[C@H1](NC(=O)C3=CC=CC(C(F)F)=N3)C24CCC4 CC1=CC=C(C(=O)N2CCC[C@H1]2C3(NC(=O)C4CC5(CCOCC5)C4)CC3)C=C1 O=C(CSC(F)F)NC[C@H1]1C[C@@H1](O)CN1C(=O)C=2C=NOC=2C=3C=COC=3 CNCCCOCCN(C)CC1=CC=C2OC=CC2=C1 C#CCCN(C)[C@H1](C(=O)NCCCOC)C1=CC=CC(C(C)C)=C1 CC=1N=C(CN)SC=1C(=O)N2CCC[C@@H1](C(=O)NC3CCS(=O)(=O)CC3)CC2 O=C(CC[C@@H1]1CCCN(C(=O)CC2=CC=CC(O)=C2)C1)NCC#CC(F)(F)F CC1=CC=CC=C1NC(=O)[C@H1](C2=CC=CC3=C2CCO3)N4C[C@H1](O)C[C@H1]4C(C)C NC(=O)C1(C(=O)NC[C@H1]2CCCCN2C(=O)C3=CC=NC(CO)=C3)CCC1 COCCCCC(=O)N1CCC2(C1)CN(C(=O)C3=CC(C(F)(F)F)=CC=C3C)C2 CC1=CC(C(=O)N[C@H1]2CCO[C@H1]2C(=O)NC[C@@H1](C)C3=NC=C[NH1]3)=NC(O)=N1 C[C@H1]1C[C@H1]1CN2N=C(C3=NC=CC=C3C(F)(F)F)N=C2CC(C)(C)C CC[C@@]1(C)CCCN(C(=O)[C@H1]2CCN(C(=O)C3=NO[C@H1]4COC[C@@H1]34)CCO2)CC1 [N-1]=[N+1]=N[C@H1]1CN(C(=O)C2=CN=C3SC=CN23)C[C@H1]1NC(=O)[C@H1]4C[C@H1]5[C@@H1](C4)C5(F)F CC1(NC(=O)[C@@H1]2CCCCN2C3CCCC3)CN(C(=O)C(F)(F)[C@H1](O)C4CC4)C1 CCN1N=CC(C(=O)N2CCCC[C@@H1](NC(=O)C3(F)CCCCC3)CC2)=C1Cl CC[C@@H1]1CN(C(=O)C=2SC(C)=CC=2OC)CC[C@@H1]1NC(=O)C=C(C3CC3)C4CC4 C=CCN=C(NC[C@H1](Cl)C(F)(F)F)NC[C@@H1]1CCCN1CCC(C)C CC[C@@H1](C)C1=CC=C(C(=O)N2CC3(CN(C(=O)CCS(N)(=O)=O)C3)C2)C(O)=N1 CCC1=NC(C(=O)N2CC[C@H1](C3CC3)[C@@H1]2CNC(=O)C#C[C@H1]4CCCOC4)=CO1 CC=1C=C(C)N2C=NC(C(=O)N3C[C@@H1]4C[C@H1]3CN4C(=O)CC5=CCOCC5)=C2N=1 CNC(=O)N1CCC[C@@H1]1C(=O)N[C@H1]2CCCN(C(=O)CCOC3=CC=CN=C3)C2 CC(C)C(=O)N1CC(CNC(=O)[C@]2(C)[C@H1]3CCNC[C@@H1]32)C1 C[C@H1](NC(=O)C1=CN(CCNC(=O)C[C@H1]2CC(=O)NC2=O)N=N1)C(=O)NC(C)C CCN1C=C(CN(C)C2=NC(N(C)CC3CCOCC3)=NC4=C2N=CN4C)N=N1 CO[C@H1](CC(=O)N1C[C@H1](C)C[C@@H1](NC(=O)C2=CN=C(C(C)C)[NH1]2)C1)C(F)(F)F COC=1C=CC(=NC(=O)NCCC2=CN(C3=CC=C(F)C=C3)N=N2)[NH1]N=1 CC[C@H1](NC(N)=O)C(=O)NC1CC(NC(=O)C2(C3=CC(F)=CC=C3C)CC2)C1 C=CC[C@@H1](NC(=O)[C@@H1](C)CC1CCC1)C(=O)NCCNC(N)=O CCCCN1N=NN=C1C(N[C@H1](C)C2COC2)CCC(N(C)C)CC CCC(=O)NC1CC(CCNC(=O)CC=2C=CN(C(C)C)N=2)C1 CC(C)[C@@H1](O)C1=CN([C@H1]2C[C@@H1](NC(=O)C3=C(Cl)N=C4C=CC=CN34)C2)N=N1 CN1C=C2C=CC=C(C(=O)N3C[C@H1](C#N)[C@@H1](NC(=O)CCC(N)=O)C3)C2=N1 C=C1CCCN(C(=O)C2CCS(=O)CC2)CC1 COC1=C(F)C=CC=C1C(=O)N2C[C@H1](CNC(=O)C=CC3=NC=CS3)[C@H1]4C[C@H1]42 N#C[C@H1]1CCN(C(=O)C[C@H1]2[C@@H1]3CN(C(=O)C=4N=COC=4C5CC5)C[C@H1]23)C1 CCCCO[C@H1](C)C(=O)NC[C@@](C)(O)CNC(=O)C1=CC=C(C)N=C1NC CC=1C=C(C(=O)N[C@H1]2COC[C@H1]2NC(=O)[C@H1]3CCCCN3C(C)C)[NH1]C=1C COCC=CC(=O)N1CC[C@]2(NC(=O)CSC3=CC=CC=C3[N+1](=O)[O-1])CCC[C@H1]12 CCSC[C@H1](C)C1=CN(CCCC(=O)NC2(C3=CC=C(OC)C=C3)CCC2)N=N1 O=C(NC1[C@H1]2CCN(C(=O)CSC=3N=C[NH1]N=3)CC[C@H1]12)C4=CSN=C4Cl COC1=CC=C2OC=C(C(=O)NC[C@@H1]3CCN(C(=O)[C@H1](C)[C@@H1](C)O)C3(C)C)C2=C1 C#CCCCN1C(C2=CC=CC=C2Cl)=NN=C1N(C)C[C@H1](C)OC(C)(C)C CC(C)/C=C/C(=O)N1CCO[C@]2(CC[C@H1](NC(=O)C3=CCC[C@H1]3C)CC2)C1 CC[C@H1]1CN(C(=O)[C@@H1]2CC(=O)N(C3CC3)C2)CCN1C(=O)C4=CC=CC(C)=C4N N#CC1=C[NH1]C(C(=O)N[C@H1]2CCN(C(=O)[C@@]3(O)CN4CCC3CC4)C[C@H1]2C(N)=O)=C1 CCCN(CCC1=CC=CS1)[C@@H1](C(=O)NC(C)C)[C@H1](CC(C)C)OC CCC1=NC=C(C(=O)N2CC=C[C@H1](NC(=O)[C@]3(CC)CCNC3=O)C2)O1 CNC=1SN=C(C)C=1C(=O)N[C@@H1]2CC[C@@H1]2CNC(=O)C3=CC=C(C(N)=O)C=N3 O=C(C[C@H1]1COCCN1C(=O)CCC(F)(F)F)NC2=C[NH1]N=C2C3=CC(F)=CC=C3 C#C[C@H1]1CN(C(=O)C=CC=2SC=CC=2C)CCN1C(=O)C=3C=NOC=3CC C[C@@H1]1CN(C(=O)C2CCN(C)CC2)CC[C@H1]1CNC(=O)C=CC3=NC=CS3 C#CC1=CC=C(C(=O)N(C)CCOCCNC(=O)[C@@H1]2CCCN2C3CC3)C=N1 CC(=O)N1CCN([C@@H1]2CCN(C(=O)C=3SC=NC=3C4CC4)C2)CC1 C[C@@H1]1CCCC=C1C(=O)N[C@H1]2C[C@@H1](CCC(=O)N3CC4(CCCCC4)C3)C2 CCCCC(=O)N1CCC(CNC(=O)COC2=CC=CC=C2)(OC)CC1 C=C(Cl)C[C@H1](NC(=O)[C@@H1]1C[C@H1](O)CN1C(=O)C2=CC=C(C)C(C)=C2I)C(=O)OC CC=1C=NN(CCCC(=O)N[C@@H1]2COC[C@@H1]2NC(=O)[C@H1]3CCC(C)(C)CO3)C=1 CC1=CC=NC=C1C(=O)N[C@@H1]2C=CCN(C(=O)[C@@H1](CC3=CC=CC=C3)N(C)C)C2 CCC1=CC=C(C(=O)NCC[C@@H1](C)N(C)C(=O)[C@H1]2CCCN2C3=NC=CS3)C=C1 CN1C(Br)=NN=C1CNC[C@H1]2CCCN2C(=O)CCCN3C(=O)CCC3=O CC[C@H1](CN(C)C(=O)[C@@H1](O)CC(F)(F)F)NC(=O)C1=COC(C(=O)OC)=N1 C=CCC(CC=C)C(=O)N[C@@H1]1CCN(C(=O)[C@@H1](CCSC)N(C)C)CC(C)(C)C1 CC1=NC(CSCC(=O)N[C@H1](C)CCCCNC(=O)CCC(C)C)=CS1 CC(C)C[C@@H1](CNC(=O)C1(O)CC(C)(C)C1)NC(=O)C2=CC=NC3=C2N=CN3C C=CC[C@@H1](CCCCC)C(=O)N1CCCN(C(=O)C2=NN(C)N=C2C)CC1 CCC[C@@]1(C(=O)N2CCC[C@@H1]2CN(C(C)=O)C3CC3)CCNC1=O CCOC(=O)CC(C)(C)C(=O)N1CCC(COC)(NC(=O)C2=CSN=C2C)CC1 COCC1=CC=C(C(=O)NC[C@@](C)(F)CNC(=O)CCC2=CC=CS2)O1 C=CC1=CC=CC(NC(=O)CN2CCN(CC3=CN=C(Br)C(F)=C3)C[C@H1]2C)=C1 COC1=NC=C(C(=O)N[C@@H1](C)[C@@H1](C)NC(=O)C2=NC=CC=3C=CN(C)C2=3)C=C1C CC1=CSC(SC2=CC=C(NC(=O)[C@@]3(C)CCCNS3(=O)=O)C=C2)=N1 CCO[C@H1](C(=O)N1CC=C[C@H1](C(=O)NCCC2=NC=CS2)C1)C3CCC3 CCCC(CCC)C(=O)N1CCN(C(=O)[C@@](C)(O)CC)C[C@H1]1CCO CC[C@H1](C)CCCC(=O)N(C)[C@@H1]1CCN(C(=O)C2=CN=C(C)O2)C1 CCCO[C@@H1]CCCN(C1=NC(NCCC#N)=CN=CN(CC)C=N1)C C[C@@H1](CCNC(=O)CN1C=NN=N1)N(C)C(=O)CC2=C[NH1]C3=CC=CN=C23 CO[C@](C)(C(=O)NCC1=CC=C(N2CCC(O)CC2)C=C1)C(F)(F)F CCCOCC(=O)N1C[C@@H1]2CCN(C(=O)C=3OC=NC=3C4CC4)C[C@H1]21 C=C1CC(CNC(=O)CNC(=O)OCC=C)(C(=O)N[C@@H1](C)C[S@@](C)=O)C1 C=CCC1(C(=O)N2CCC3(CCN(C(=O)C(CC)CC)C3)CC2)CC=CC1 C[C@@H1](O)[C@H1]1CCN1C(=O)C2=CC(CNC(=O)CN3CC(C)(C)C3)=NO2 C=CC(C)(C)CC(=O)NC1([C@H1]2CCCN2C(=O)C[C@H1](C)C(C)(C)CC)CC1 CC[C@H1](CN(C)C(=O)COC=1C=NN(C)C=1)NC(=O)[C@@H1](O)CC2CCCC2 O=C(N1CCC2=CC=NC=C2C1)[C@@]34C[C@@H1]3CN(CC5=CC=CC6=CN=CC=C56)C4 CCOC[C@H1](NC(=O)C1=CCSC1)C(=O)N[C@@H1](C(=O)NC)C2CC2 COC1=C[NH1]N=C1C(=O)N[C@@H1]2C[C@H1]3C[C@@H1](C2)N(C(=O)[C@@H1]4CCCO[C@@H1]4C)C3 CC[C@H1]1CCC[C@@]1(C)C(=O)NCCCNC(=O)C2=CC(N)=C3N=CC=CC3=C2 CNC(=O)CCCNC(=O)[C@H1]1COCC[C@@H1]1NC(=O)[C@H1](C)N2C=CN=C2C CO[C@H1](CC1CCCC1)C(=O)N2[C@H1]3CC[C@H1]2CN(C(=O)[C@]4(C)C=CCC4)C3 CC1=C(CNC(=O)[C@@H1]2COCCN(C(=O)C=3C=C4N(N=3)CCO4)C2)CCC1 CCCC1=CC=CC=C1C(=O)N[C@H1](CCNC(=O)CN2[C@@H1](C)CC[C@@H1]2C)C(C)C CC=1N=NSC=1C(=O)N2C[C@H1]3CN(C(=O)C4=COC=N4)C[C@@H1]32 C[C@H1]1C[C@H1](C2=CC=CC(C(F)(F)F)=C2)CN(CC3=CC(Br)=CS3)C1 O=C(NC1(CNC(=O)C=2C=NN(CC(F)F)N=2)CCCCC1)C3=CC(Cl)=NO3 CC1(NC(=O)[C@@H1](NC(=O)C2=NC=NC(O)=C2F)C3=CN(C)N=N3)CSC1 CCS(=O)(=O)C=CC(=O)N1CCC2(CCCN2C(=O)[C@H1](F)N3C=CC=N3)CC1 C[C@H1]1C[C@H1](NC(=O)C2=CCOCC2)CN1C(=O)CC3CC4(CC4)C3 CC(=O)C1=CC(F)=CC=C1NC(=O)NC(C)(C)C=2C=CN(C)N=2 CC(C)CNC(=O)[C@H1](C1=CC(Cl)=NO1)N2C[C@@H1](O)C[C@@H1]2C3=CC=C(F)C(F)=C3 COC1=N[NH1]C=C1C(=O)NC[C@H1]2CCCCN2C(=O)CC[C@H1](C)S(C)(=O)=O C=C(Cl)CCC(=O)N[C@@]1(C(=O)N2CC[C@@H1]2C)CC1(C)C CC(=O)N(C)[C@H1](C)C(=O)N1CC[C@](C)(CNC(=O)C2=CC(N)=CC=C2C)C1 CC1=CC=NC(O)=C1C(=O)N2C[C@@H1](C)CN(C(=O)C3=CC(=O)C=C[NH1]3)[C@H1](C)C2 CCCCO[C@H1](C)C(=O)N1CCN(C(=O)CC2=CSC(C)=N2)C[C@@H1]1CCOC CNC(=O)[C@@H1](CCC1OCCO1)N2CCC3=C(O)C=CC=C3C2 COC1CC2(C1)CN(C(=O)[C@H1]3C=CCN3C(=O)[C@H1]4CC[C@H1]5C[C@H1]54)C2 CC1=CC(CCC(=O)NC[C@]2(F)CCN(C(=O)[C@@H1]3CC4=CC=CC=C43)C2)=NO1 COC1=CC=C(Cl)C(C(=O)N2C[C@H1]3C[C@@H1]2[C@@H1]3C(=O)NC4=CC(C)=CN=C4OC)=C1 CC[C@](C)(F)C(=O)N1CCN(C(=O)C2=C(C)CCOC2)[C@H1](C)C1 CCSCC(=O)N1C[C@@H1]2C(CNC(=O)C=3SC(OC)=NC=3Cl)[C@H1]2C1 CCC1=CC=C(C(=O)NCC[C@H1](O)C(=O)NCCN(C)C)C=C1 COC[C@H1](NC(C)=O)C(=O)N1CC[C@H1](CCNC(=O)C2=CC(Cl)=C([N+1](=O)[O-1])[NH1]2)C1 CN(CC1(O)CCN(C(=O)[C@H1]2COC(=O)O2)CC1)C(=O)C3CS(=O)(=O)C3 CN1CCC[C@@H1]1CCC(=O)NC[C@]2(C)CCCN2C(=O)CC3=CC=CC=C3CO CC(=CC1CC1)C(=O)N[C@H1]2CCN(C(=O)[C@@H1]3CCCSC3)[C@@H1](C)C2 CC1=NN(C2CC2)C=C1C(=O)NC[C@]3(C)CCN(C(=O)C4=N[NH1]C=C4[N+1](=O)[O-1])C3 CCCCCS(=O)(=O)CC(=O)NCC(C)(C)CNC(=O)C1CC2(CC(OC)C2)C1 CCC1=CC(Cl)=CC=C1C(=O)NC(C)(C)C2CCN(C(=O)[C@@H1](O)C3CC3)CC2 NC1=CC(C(=O)NC[C@H1](NC(=O)[C@H1]2C[C@@H1]3C[C@@H1]3C2)C4CCCC4)=CN=C1Cl C#CC1=CC=C(C(=O)NC2=CC=CC(CNC(=O)[C@@H1]3CCCC3(F)F)=C2)C=N1 CC1CN(CC(=O)NC[C@H1](C)N2C=C([C@H1](O)CC)N=N2)C1 CSC1=NSC(N2CC[C@H1](CNC(=O)C3CC4=CSC=C4C3)C[C@H1]2C)=N1 CCN(C(=O)C1=NC(Br)=C[NH1]1)[C@@H1]2CCN(C(=O)CCC3CC(F)(F)C3)C2 CC=1SC=NC=1C(=O)NC2(CNC(=O)[C@@H1]3C4=C[NH1]N=C4CC[C@@H1]3C)CCOCC2 C=C(C)CN1N=NN=C1C2(NCCS(=O)(=O)C(C)C)CCC(C(=O)OC)CC2 COC1=NC=C(C(=O)N[C@H1](C)CC2CCN(C(=O)C=3SC=CC=3C)CC2)C=N1 CN1C=CC=C1CCC(=O)N(C)[C@H1]2CN(C(=O)[C@@H1]3C[C@@H1]4CC[C@@H1]4C3)CC25CC5 O=C(NCCC1(O)CN(C(=O)[C@@H1]2CC=CCC2)C1)C3=CC=4SC=NC=4[NH1]3 C#CCCC(=O)NCCCCN(C)C(=O)CCCC1=CC=C(Cl)C(Cl)=C1 O=C(NCC(F)F)[C@H1](C1=CC2=NC=CC=C2S1)N3CC[C@H1](O)[C@H1](CO)CC3 CN(C)CC1=CC=C(C(=O)N[C@H1]2C[C@H1]2NC(=O)C=CC3=CC=C(C(N)=O)O3)C=N1 CC(C)C[C@H1](O)C(=O)N[C@H1](C(=O)NCCCCN1CCCC1)C2(O)CCC2 CO[C@@H1](C)CNC(=O)[C@@H1](NC(=O)C1CCSCC1)C=2C=NN(C)C=2 C[C@H1](C[C@@H1]1CCCO1)C(=O)NCC2(C)CCN(C3=CC(O)=NC(=O)N3C)CC2 O=C(N[C@@H1]1CC2(CCCC2)OC3=CC=CC=C31)C=CC4=CN=C([C@@H1]5CCCO5)O4 CO[C@@H1](C(=O)NCCCNC(=O)CSC(C)C)C1=CC=C(O)C=C1 C[C@@H1]1CCN(C(=O)/C=C/CN(C)C)C[C@@H1]1NC(=O)C2=CC=3C=CSC=3C(O)=N2 CC(C)COCC(=O)N[C@H1](CO)CNC(=O)C1=CC(Cl)=NS1 CC(C)C1=NC=C(C(=O)N(CCC(=O)N(C)CCCN2CCCC2)CC3CC3)O1 CC(C)[C@@H1](C)[C@@H1](CNC(=O)C1CCCCCC1)NC(=O)C=2C=N[NH1]C=2 CC1(C(=O)NC2=CC=CC(NC(=O)C[C@@H1]3CCC[C@@H1]3C)=C2)CC4(CCC4)C1 C[C@H1](C(=O)NC[C@@]1(C)CN(C(=O)C2=CC=CC(O)=N2)CCO1)C3=CC=CC(F)=C3 CC[C@@H1](C)[C@@H1](C(=O)N1CC(C(F)(F)F)C1)N(C)C(=O)CSC(F)(F)F CCCCCC(=O)NCC(=O)N1[C@H1](CNC(=O)[C@H1](O)CCCC)C[C@@H1]2COC[C@H1]21 COC(=O)CCN(C(=O)CC1CC2(C1)CN(C3=NC=C(F)C=N3)C2)C4CC4 C=C(C)CNC(=O)[C@H1](C1=CC(Br)=C(Cl)S1)N2CC[C@@H1](NC(=O)OC)C2 CC(C)(CC(F)F)C(=O)NC[C@]1(C)COCCN(C(=O)[C@H1]2C[C@H1]3[C@@H1](C2)C3(F)F)C1 CCCCCCCCCC[C@@H1](C)NC[C@@H1](CO)CC1=CC=CC=C1F C[C@H1]1CCCC[C@]1(C)C(=O)NC[C@H1](CO)NC(=O)C2=CC(Cl)=C(Br)S2 COC[C@H1](C)NC(=O)[C@@H1]1C[C@@H1]2C[C@H1]2N1C(=O)C3=CC=CN=C3C4=CC=CC(C)=C4 C[C@H1](C(=O)N[C@@H1]1[C@H1]2C[C@@H1]1N(C(=O)C3=NC=C(Cl)C=C3O)C2)C4=CC=CC=C4Cl COC(=O)[C@@H1]1CC[C@@H1](C)N(C(=O)C(=O)NC2=NC=CC=C2C3CC3)C1 CSCC[C@H1](O)C(=O)NCC#CCNC(=O)[C@@H1](C)N1C(=O)C2=CC=CC=C2C1=O CCC(C)(C)[C@H1](C)NC(=O)C[C@H1]1CN(C(=O)C2(Cl)CCCCC2)CC13CC3 C#CCCN(C)CC(=O)N1C[C@@H1]2C[C@]2(NC(=O)C3=NC=CC=4[NH1]C=CC3=4)C1 CN(C)C1=CC=C(N[C@@]2(C3=NN=NN3C)CCC(=O)N(C)CC2)C=N1 CCO[C@@H1]1CN(C(=O)C2=CC(=O)C=C(Cl)[NH1]2)C[C@H1]1CNC(=O)C3(OCC)CCC3 COCCO[C@@H1](C)C(=O)NC[C@@]1(OC)CCN(C(=O)C2=CC=CC=3OC=CC2=3)C1 CN1C=CC(C(C)(C)C(=O)N2CC[C@H1]3[C@H1](CCCN3C(=O)CC[S@](C)=O)C2)=N1 C[C@H1](N[C@H1]1CC=C(C(F)(F)F)CC1)C2=CC(F)=CC=C2N3CCOCC3 CC(=CC1=CC=CC=C1)C(=O)N2CC[C@H1](C(=O)NCC3=NC=NN3C(C)C)C2 O=C1C[C@H1](CC(=O)N[C@H1]2CCCCN(C(=O)COCCCF)C2)CN1 C=CC=CCC(=O)N1CC=C[C@@H1](NC(=O)C2=CC=NC(O[C@@H1](C)CC)=C2)C1 CC1=CC=C2C(C(=O)NCP(C)(C)=O)=CC=CC2=C1 COC[C@@](C)(O)CC(=O)NC[C@@H1]1C[C@@H1](OC)CN1C(=O)C2C3(CC3)C24CC4 CC[C@H1](SC)C(=O)N[C@@]12CCC[C@@H1]1N(C(=O)CN3N=C(C)N=C3C)CC2 CCC1=CC=CC(C(=O)N[C@](C)(CC)CNC(=O)CC=2N=C3N=CC=CN3N=2)=N1 CC[C@@H1](C)CC(=O)N[C@@H1]1C[C@H1]1CNC(=O)C(C)(C)NC(=O)C(F)(F)F C[C@@]1(C(=O)N2CC(CC3(O)CN(C(=O)CC(=O)NC4CC4)C3)C2)C[C@@H1]5C[C@@H1]5C1 COCCC[C@H1](C)C(=O)NCC[C@@H1]1CCCN(C(=O)C23CC(CO2)C3)C1 COC(=O)[C@H1]1CC[C@H1](CNC(=O)[C@H1]2C[C@H1]2NC3=NC(C)=C4C=CC=CC4=N3)CC1 CC(C(=O)N1CCN(CCCNC(=O)[C@H1]2CCC(F)(F)[C@@H1]2O)CC1)=C3CCCC3 CC1=CN=CN=C1C(=O)N2CC[C@H1]3[C@@H1](CCCN3C(=O)C=4C=CN(C)C(=O)C=4)C2 CCN(C)CCC(=O)N[C@H1](CC(=O)NCCCN(C)CC(C)C)C(C)C CC=1[NH1]N=C2C=CC(NC(=O)[C@H1]3C[C@@H1](F)CN(C(=O)/C=C/C(C)C)C3)=CC=12 C=CCN1C=CC=C1C(=O)NCC2=CC(O)=CC(CNC(=O)[C@@H1]3[C@@H1](C)C[C@H1]3C)=C2 CO[C@@H1](C)[C@H1](O)C(=O)N1CCC2(CCCN2C(=O)C3=CC(C)=CS3)CC1 CO[C@@H1]1C[C@H1]1C(=O)NC[C@H1]2CN(C(=O)C3=CC(C)=CC=C3C)CC24CCC4 C[C@@]1(NC(=O)C2=CC=C3SN=NC3=C2)CCN(C(=O)C4(C(F)F)CCCCC4)C1 CC1=NN=C(C2=CC=CC=C2C(=O)NC[C@@H1](C)NC(=O)C3=CSC([N+1](=O)[O-1])=C3)O1 CN(C)C1CCN(CC(=O)N[C@@H1]2CC[C@@H1]3CN(C(=O)C(C)(C)F)C[C@H1]3C2)CC1 C=CCC(C)(C)CCNC(=O)[C@@H1]1CCN(C(=O)C=2C=C[NH1]C=2CC)[C@H1]1C(C)C BrC1=CC=CC(C2=CSC(CN3CCC[C@@H1]3COCC4=CC=CC=C4)=N2)=C1 CCN1C=CN=C1C=CC(=O)N[C@@H1]2[C@@H1]3CC[C@H1]2N(C(=O)[C@@H1](OC)C(C)C)C3 CC1=NN(C)C(C(=O)N[C@H1]2C[C@H1]3C[C@H1]2CN(C(=O)C4=CC=CC=C4Cl)C3)=C1Cl O=C(C1=CC2=CC(Cl)=CC=C2O1)N3CCO[C@@H1](CNC4=NC=C5N=CN=C5[NH1]4)C3 CNC1=CN=CC=C1C(=O)N2CC3(C)CC2(C(=O)NC[C@@H1](C)CCCC(C)C)C3 CC1=NO[C@H1](C(=O)NCCC2(NC(=O)C3=CC=C(C4=CC=CO4)N=C3)CC2)[C@H1]1C CC(C)N(C)C(=O)CCC(=O)N[C@H1](C)C1=NC=C(C(F)(F)F)C=C1Cl O=C(C[C@H1]1CN2CCN1CC2)N[C@H1]3CCN(C(=O)C4=CC=NC=C4F)C3 CC1=NC(C)=C(CC(=O)N[C@@H1]2CCC23CCN(C(=O)[C@]4(C)C[C@H1]4C)CC3)C(O)=N1 C=CCC1(NC(=O)[C@H1](C)CN(C)C)CCN(C(=O)[C@@H1]2COCCN2C)CC1 C=C[C@H1]1CCCN1C(=O)C[C@H1]2COCCN2C(=O)C=3C=CSC=3OC CCOCC[C@H1](NC(=O)C=C(C)COC)C(=O)N1CC(C)(C2CCC2)C1 CCSCC(=O)NC1CC(N(C)C(=O)C2=CCCSC2)C1 CN(CC(C)(C)CNC(=O)CC[C@@]1(C)CCC(=O)N1)C(=O)C2=NS[NH1]C2=O CC(C)C[C@H1](C)CC(=O)N1CCCC(N(CCF)C(=O)CCCC(F)(F)F)C1 N#CCC(=O)N[C@@H1]1C[C@@H1]2CN(C(=O)C3=CC(F)=CC=C3F)C[C@@H1]21 CC1=CCS[C@@H1]1C(=O)N2C[C@H1]3C[C@H1](NC(=O)CCCNC(N)=O)C[C@H1]2C3 CC(C)[C@@H1](C)[C@H1](CNC(=O)CCS(=O)(=O)N(C)C)NC(=O)C1(C(N)=O)CCC1 CO[C@]1(C(=O)N2CCN(C(=O)[C@@H1]3[C@H1]4CC[C@@H1](C4)C3(C)C)CC2)CCCOC1 C[C@@H1]1CN(C(=O)[C@@H1]2CCCN3N=CC=C32)C[C@@H1]1NC(=O)C=4C=NN(CCO)C=4 CCCS(=O)(=O)CC(=O)N1CCC[C@@H1]1[C@@H1](C)NC(=O)C2=NC=NC(O)=C2Cl CCC1=CC=NC(C(=O)N[C@@H1]2C[C@H1](O)CN(C(=O)C3(S(N)(=O)=O)CCC3)C2)=C1 O=C(CN1CCCCC1)NC2(CNC(=O)C3=CC=CC4=CC=NC=C34)CC2 C[C@H1](NC(N)=O)C(=O)N[C@H1]1CCN(C(=O)C=CC2=CC=C(Cl)S2)CC(C)(C)C1 CCCC(=CC(=O)N1C[C@@H1](NC(=O)C2=CC([N+1](=O)[O-1])=N[NH1]2)CC3(CC3)C1)CCC CN1C=NC=C1C(=O)N2CCC3(CC2)C[C@@H1]3NC(=O)C4=CC=CC(OC(F)F)=C4 CC1=CC=C(C(=O)N[C@H1]2CN(C(=O)C3=NC=C(C(F)F)S3)CC24CCC4)S1 CCC[C@@H1](O)C(=O)N1CCC2(CC(NC(=O)C(C)(C)C3CCC3)C2)C1 CC(C)N1C=NC(C(=O)N[C@H1]2CC[C@H1](C)N(C(=O)CCS(=O)(=O)C(F)(F)F)C2)=C1 COCCCCCC(=O)N[C@@H1]1COC[C@@H1]1NC(=O)C[C@@H1]2SC(=N)NC2=O CO[C@H1](C(=O)N1CCO[C@@H1](C2CC2)C1)C3CN(C(=O)C4(CO)CC4)C3 CCN(C(=O)[C@@H1](C)C1=CC=C(C)S1)[C@@H1]2CCN(C(=O)C3=C[NH1]N=C3S(N)(=O)=O)C2 CCN(CCO)C(=O)C1=CC=C2C(=C1)CCN(C(=O)C3(F)CCCCC3)C2 CC1=COC(C(=O)N[C@H1](C)C2CC(NC(=O)[C@H1](F)C3CCC3)C2)=C1 CS[C@H1](C)CCC(=O)N1C[C@@H1](NC2=NC=NC=3C=C(C)[NH1]C2=3)C4(CCC4)C1 O=C(CCOC1COC1)NC[C@@H1]2CCCN2C(=O)[C@@H1]3[C@H1]4CC[C@@]3(C5=CC=CO5)C4 C=C=C(C)CC(=O)N(C)C[C@H1](C)NC(=O)C1=CC=C2C=NC=C(Br)C2=N1 COC1=CC=C2C=C(C(=O)N3CCN(C(=O)[C@H1]4CC4(Cl)Cl)[C@@H1](C)C3)C=CC2=C1 N#C[C@@H1]1CCCC[C@@H1]1NC(=O)[C@H1]2CC3(CCC3)CN2C(=O)C=CC4=CC=CC=C4 CC1=CC=C(C(=O)NC[C@@](C)(F)CNC(=O)CO)C=C1C#N CC1=CC(O)=CC=C1CC(=O)N[C@@H1](C)CN(C)C(=O)C(C)(C)C2=CC=CC=C2 CC(C)C(F)(F)CC(=O)N1CCN(C(=O)C2=CN(C[C@H1]3CCOC3)N=N2)CC1 C#C[C@@]1(C(=O)N2CCC(O)(CC)CC2)CCN(C(=O)C3=CSC=C3CC)C1 O=C(/C=C/C1=CC(F)=CC(F)=C1)NC[C@H1]2CCCN(C(=O)CC[C@H1]3CC3(Cl)Cl)C2 CC1=CC=NN1CC(=O)N[C@H1](CCC2CCCCC2)C(=O)O CC(C)C1=NSC(CN2CCC[C@@H1](NC(=O)[C@@H1](CC3=CC=CC=C3)C4CC4)C2)=N1 COC1=CC(C(=O)N[C@H1]2C[C@](C)(NC(=O)C3=CN=C4[NH1]C(O)=NC4=C3)C2)=NC=N1 C[C@@H1](CNC(=O)C[C@H1]1CCS(=O)(=O)C1)CN(C)C2=CN=CC(Cl)=N2 COCCOC1=CC=CC(C(=O)N2C[C@@H1]3CCC[C@H1](C2)N3C(=O)C4[C@H1](C)[C@H1]4C)=C1 CC1=NSC=C1C(=O)N[C@@H1]2CN(C3=NC=C(OC4=CC=CC=C4)C=N3)C[C@H1]2C#N CN1C([N+1](=O)[O-1])=CN=C1C(=O)NCCN(C(=O)CSC(C)(C)C)C2CC2 O=C(NC=1C=CSC=1C(=O)NCC=2C=COC=2)C=3SC=NC=3C(F)(F)F C[C@H1](NC(=O)C=1C=COC=1)[C@@H1]2CN(C(=O)COC3CC3)CCO2 CC[C@H1](O)C(=O)N1C[C@H1]2CC[C@H1]1[C@@H1]3CN(C(=O)C4=CC=5C=CSC=5C(O)=N4)C[C@@H1]23 N=C[NH1]C=C(C(=O)N[C@H1](CNC(=O)C=1C=N[NH1]C=1)C2=CC=CC(C=3N=N[NH1]N=3)=C2)O CC1=NO[C@](C)(CN=C2C=C(C)[NH1]C(=NC[C@@H1]3CCCCC(F)(F)C3)[NH1]2)C1 CCC(C)(C)C(=O)C(=O)N1CCO[C@@H1](C(=O)N2CC[C@@H1](CO)C2)CC1 CC1=C(Cl)C(C(=O)N[C@@H1]2C[C@@]3(NC(=O)COCCF)CO[C@@H1]2C3C)=NN1C COCC[C@@H1](CNC(=O)C1(N(C)C)CCC1)NC(=O)CSC2=CC=CC=N2 C=C(C)CCCC(=O)N(CC(=O)N[C@H1](C)C[C@@H1]1CCOC1)C(C)C CC1=CN(C)C=C1C(=O)N[C@H1]2CCCC[C@H1]2C(=O)N3CCC4(CCOCC4)C3 CC1=CC=C(F)C(C(=O)N2C[C@@H1](CNC(=O)C3CC4(CC4)C3)C(F)(F)C2)=C1F CSCCN1CCN(N2CCC3(CC2)NC(=O)CN3C)CC1 CC(C)(C)C(=O)C(=O)N1CCN([C@H1]2CCN(C(=O)CN3CCC(O)CC3)C2)CC1 C#CCCCCC(=O)N[C@]12CCC[C@@H1]1N(C(=O)C3=CN(C[C@H1](O)CC)N=N3)CC2 CCC(CC)(CO)C(=O)NC[C@@H1]1CCC[C@H1]1NC(=O)C2=CN(C)N=C2C3CCC3 CO[C@@H1](CC1CCC1)C(=O)N[C@@H1](C(=O)NCCC(C)(C)C)C2=CC=CN=C2 COC1=C(C)C=C(C(=O)NCC(CC(C)(C)CNC(=O)C2=CC(C)=CS2)=C)C=C1 CC(C)N(C)CCCCC(=O)N1[C@H1](CNC(=O)[C@H1](O)C2CCCC2)[C@H1]3CC[C@@H1]1C3 CC1=CC=C(F)C=C1CC(=O)N[C@@H1]2CCOC3(CCN(C(=O)[C@@H1]4C[C@@H1]4C)CC3)C2 CC(C)[C@@H1]1[C@@H1](NC(=O)CCCCC(F)(F)F)CCN1C(=O)C2CC2 CC(=O)OC1(C(=O)N2CCCN(C(=O)CC3=CC=C(Br)C(F)=C3)[C@H1](C)C2)CC1 CCCC[C@H1](NC(=O)C[C@@H1]1CCC[C@H1]2C[C@H1]12)C(=O)NCC=3C=NN(C)C=3 C#C[C@@]1(C(=O)NCC(C)(C)CC)CCN(C(=O)C2=NC=C(CC)C=N2)C1 CC(C)[C@H1](CCN(C)C(=O)CNS(N)(=O)=O)NC(=O)[C@H1](O)CN(C)C O=C(CC1CCSCC1)NC[C@@H1]2CCCN(C(=O)C3(CF)CC3)CC2 CC=1SC=C(CNC(=O)C2(NC(=O)CNC(=O)CC(C)C)CC(CO)C2)C=1C C=C1CC(C(=O)N2CC[C@@H1]3C[C@@H1](C(=O)NCC4CC5(C4)CC56CCC6)[C@@H1]3C2)C1 CC=1C=NN(CC(=O)N2CC=C(C(C)(C)C(=O)NCC3=CSN=N3)C2)C=1 CCC[C@H1]1CN(C(=O)CC2=CC=C(C(N)=O)C=C2)CCN1C(=O)CCCSC CCCC=1C=C(C(=O)N[C@@H1]2CC[C@H1]2NC(=O)C(F)(F)CCC)N(C)N=1 COC1=CC=C(S(=O)(=O)N[C@@H1]2CN(C3=NC=C(C4CC4)C=N3)C[C@@H1]2F)C(F)=C1 O=C(OCC1=CC=C(OCCF)C=C1)C2=C[NH1]N=C2C3=CC=CC(C(F)(F)F)=C3 CC(C)COCCC(=O)N1CCO[C@H1](CCCNC(=O)COC2CC(F)(F)C2)C1 CCCC(=O)NCC(=O)N1CCC[C@H1]1C(=O)N(CC)[C@@H1](C)C2CCC2 C[C@@H1]1CCN(C(=O)CCCC(N)=O)C2=C(O)C=CC=C21 CC1=CC=CC(CC(=O)NCC2=NC3=CC(C)=CC=C3N2)=C1C CCC=C(CCC)C(=O)N(C)C[C@@H1](O)CN(C)C(=O)C1CC2(CSC2)C1 C#CC1(C(=O)N[C@H1](CC)C[C@H1](C)O)CN(C(=O)C2C[C@H1](C)C[C@@H1](C)C2)C1 C[C@H1]1CCC[C@@H1]1CC(=O)N2CC(N3CCN(C(=O)C=4OC=NC=4C5CC5)CC3=O)C2 C=CCCOCCCCC(=O)NC[C@](C)(CC)NC(=O)C1CC2(CCC2)C1 O=C(NC[C@@H1]1C[C@@H1](NC(=O)[C@@H1](F)CC2CCC2)CCO1)C3=CC=CS3 CC1=NC=C(CCC(=O)N[C@]2(CF)CCN(C(=O)CCC3=CN=N[NH1]3)C2)O1 COCC(=O)NCCC(=O)N(C)CCCNC(=O)C1=CC=CN2C(O)=NN=C12 COC1=CC=C(F)C(NC(=O)[C@H1]2C[C@H1](O)[C@@H1](NC(=O)CCCC3=CN=N[NH1]3)C2)=C1 CC(C)N1CCC[C@H1]1C(=O)N2CC3=CC=CC=C3C[C@H1]2CNC(=O)C4(F)CCC4 CCSC1=CC=CC=C1CC(=O)NCC2(CNC(=O)[C@]3(OCC)CCOC3)CC2 C[C@@H1](CC1CC1)C(=O)NC[C@@H1]2CCC3(CCC3)CN2C(=O)C4=CSN=C4Cl CC1=NC(N2CC(C)(C)C[C@H1]2CNC(=O)C3=CC=C(Cl)C=C3Cl)=CC4=NN=CN14 CC[C@@H1]1CN(C(=O)C[C@H1]2CC[C@@H1](O)C2)CCN1C(=O)C3=CN=C(SC)N=C3O O=C(/C=C/C1=CC=C(F)C=C1F)N2[C@H1]3CCC[C@H1]2CN(C(=O)[C@@H1]4CCCCO4)C3 CC1=CC(Cl)=C(Cl)C=C1NC(=O)[C@@]2(O)CCN(C(=O)C3=CC=CC4=CC=NN34)C2 CC1=NOC(C)=C1C(=O)NC[C@H1]2[C@H1](C)CCN2C(=O)C=3C=C(C(F)F)[NH1]N=3 C=C1CCC(C(=O)N2CCC3(CC3)C[C@H1]2C(=O)N(C)C4CC4)CC1 CN1CCN(C2CN(CC(=O)C(C)(C)CCC(=O)OC(C)(C)C)C2)CC1 C[C@@H1](C(=O)N[C@H1](C)[C@H1](C)NC(=O)[C@@H1]1[C@H1]2CCCO[C@H1]21)C3=CC=CN=C3 CC[C@@H1](C)C(=O)N(C)C[C@H1](O)CNC(=O)C1=CN(CCO)N=N1 CSC1=CC=C(C(=O)N[C@]23CO[C@H1](C2)[C@H1](NC(=O)C(C)(C)C4=CC=C(Cl)C=C4)C3)O1 CCC/C=C/CN=C1N=C2SC=CC2=C(N(C)CC(F)(F)C3=CC=CC=C3)[NH1]1 CC=1C=C(C(=O)N2[C@H1]3CC[C@H1]2CN(C(=O)[C@H1]4CCCC5=CC=NN54)CC3)[NH1]C=1C CCOC(OCC)C(=O)N[C@@H1]1CC[C@H1](CCC(=O)NCCCN2CCOC2=O)C1 COC(=O)C1(C)CN(C(=O)[C@@H1](CC(F)F)N(C)C(=O)C2=C[NH1]C=CC2=O)C1 COCCOCC(=O)N1CCC[C@H1](CN(C)[C@@H1](C)C2=CC(F)=CC=C2F)C1 CCCCOCC(=O)N1C[C@@H1](N(C)C(=O)C[C@H1](O)CC)C2(CC2)C1 C=C[C@@](C)(O)C(=O)NC[C@@H1]1C[C@H1]1CNC(=O)C2=CC=NC(N3CCC[C@@H1](C)C3)=C2 CN1C=C2C(=N1)C[C@@H1](C(=O)N3CC4(C[C@@H1](NC(=O)CCN5CCC5)CO4)C3)CC2 CC1=CC=C(C(=O)N(C)[C@@H1](CC(C)C)C(=O)NC2(CC3CCC3)CC2)N=N1 C[C@H1](CC=1C=NN(C)C=1)C(=O)N(C)[C@H1](C)CCNC(=O)C2=C[C@@]3(CCOC3)C2 CCC1=NC=CN=C1C(=O)NC[C@@H1](F)C2CCN(C(=O)C3=CC=CC=C3)CC2 COCC1(CC(=O)N[C@@]2(C)CCN(C(=O)/C=C/C3=CC=C(Br)C=C3)C2)CC1 CO[C@@H1](F)C(=O)N1CC2(CCC(NC(=O)C3=CSC(CS(C)(=O)=O)=N3)CC2)C1 CC1=CC(O)=NC=C1C(=O)N[C@]23COCC[C@H1]2CN(C(=O)C4=CC=CC(O)=N4)C3 CCO[C@@H1](C)C(=O)NC1CC2(CC[C@@H1](CNC(=O)C3=CC=CN=C3F)OC2)C1 CC=1C=NN(C)C=1CC(=O)N2CC[C@@](C)(CC(=O)N(C3CC3)C4CC4)C2 CC[C@@H1](CNC(=O)[C@H1](CCC(=O)OC)N(C)C)NC(=O)CCCC(C)C C[C@H1](C1CCC1)[C@H1](NC[C@@H1]2CC23CCC3)C4=NN=NN4CC5=CC=C(F)C=C5 CCNC(=O)NCCN1C[C@H1](C)C[C@@H1](O)C1 C[C@H1]1CC[C@@H1](C)N1CC(=O)N2CC(CCNC(=O)C3=NC=C(Cl)N3C)C2 CSC1=CC(C(=O)N2C[C@H1](CNC(=O)C3=C[NH1]C(C#N)=C3)C[C@@H1]2C)=C(C)O1 O=C(CC(F)(F)C(F)F)NCCCC1(NC(=O)[C@@]23CCC[C@@H1]2CC3)CC1 C=C[C@@H1](CC)CC(=O)N[C@H1]1C[C@@H1](F)CN(C(=O)C2=CN=C3C=CC=C(C)N23)C1 O=C(NC1=CC(Br)=CC(I)=C1)[C@H1]2CN(CC3=CN=C(Cl)C=C3F)CCC2(F)F CCC[C@H1](C)C(=O)NCCCN1CCN(C(=O)C2=CC(SC)=CC=C2Cl)CC1 COC1=C(CC(=O)NC[C@H1](O)C2(C)CC2)C=CC=C1C=3N=N[NH1]N=3 CNC(=O)N[C@@H1](C)C(=O)NCCN1CCCN(C(=O)[C@@H1]2C[C@@H1]2C(F)F)CC1 CC(C)C[C@@H1](O)C(=O)N1CCC2(C1)CN(C(=O)C=3SC=C4C=3CCCC4)C2 COC1=NC=CC(C(=O)N[C@H1](C)CCN(C)C(=O)[C@@]2(C#N)CCCC(=O)C2)=C1F CC[C@H1](NC(=O)[C@]1(NC(=O)C=2C=CN(C(F)F)N=2)CCC[C@H1]1C)C3=NC=NN3C O=C(CC1=NN=CO1)N2CC[C@@H1]3CCN(C(=O)C=4C=NN(C(F)F)C=4)C[C@@H1]3C2 C[C@@H1](CNC(=O)C1=CSC=N1)N(C)C(=O)[C@@H1](O)CC2=CN=C[NH1]2 COC(=O)N[C@H1](CC(C)C)C(=O)NC1(CNC(=O)[C@H1](C)CO)CC1 CC1=CC(NC(=O)CC(C)(C)NC(=O)[C@@H1]2CC=CCC2)=CN3C=CN=C13 C=CN1N=CC=C1C(=O)N2C[C@@]3(CNC(=O)C4=CSC(O)=N4)C[C@H1]2CO3 CCN(CCNC(=O)C=CCOCC(F)(F)F)C(=O)[C@H1]1CC(=O)OC1(C)C C=CC[C@@H1](OC)C(=O)N[C@@H1](C(=O)NCC(=O)NC(C)C)C1=CC=CS1 C#CC[C@]1(C(=O)NC2CC(CNC(=O)C=3C=CN(C(C)C)N=3)C2)CCOC1 O=C1NC[C@@H1]2CN(C(=O)C3=C[NH1]C4=NC=C(C5=CN=NC(F)=C5)C=C34)C[C@H1]12 CCOC(=O)[C@@H1](F)C(=O)N1C[C@H1](C(=O)N2CCC3(CC(CO)C3)C2)C(C)(C)C1 O=C(N[C@@H1]1[C@@H1]2C[C@H1]3[C@@H1](C2)CN(C(=O)C4CSC4)[C@H1]31)[C@H1]5CC6CCC5CC6 C=C[C@H1](O)C(=O)NC[C@H1]1CC[C@@H1](NC(=O)C2=NC=CC=C2F)C1 CCN(CCN(CC)C(=O)C1=NC(Cl)=CC=C1N)C(=O)C2=CN(C)C=N2 CCC1=NOC=C1C(=O)N2CC[C@@](CO)(NC(=O)C3=CSC4=NC=NC(O)=C34)C2 O=C(CN1C=CC=N1)N[C@@H1]2CCC[C@]23CCN(C(=O)CCC4=CC=C(F)N=C4)C3 C=CCOC(=O)NCC(=O)N1C[C@H1](NC(=O)[C@@H1](O)C2=CC=CC=C2F)CC1(C)C CCC1=CC(C(=O)N2CC[C@H1](N(CC)C(=O)C3=CC(OC)=CS3)C2)=NC=N1 C#CCCCC(=O)NCC1(C)CCN(CC2=CC=C(S(C)(=O)=O)C=C2)CC1 C#CCSCC(=O)N[C@H1]1C[C@H1]2CN(C(=O)C34CCCN3CCC4)CCN2C1=O CC(C)N1C=CC(CNC(=O)NCCC(=O)NC2=CC=CC=C2)=N1 CS(=O)(=O)C1=CC=C(F)C(C(=O)N[C@@H1]2CC[C@@H1](C(=O)NC[C@@H1](F)CO)C2)=C1 CN(C(=O)C=C1CCCCC1)[C@@H1]2CCC[C@@H1](NC(=O)C=CC3CCC3)C2 C=CC[C@]1(C(=O)N[C@H1]2CCN(C)C[C@H1]2C)CCN(C(=O)C=3[NH1]C=CC=3C)C1 CC1=NC(=N)[NH1]C(=NC[C@@H1](C2CC2)N(C)C(=O)[C@H1]3CCOCC3(C)C)[NH1]1 CC[C@@](C)(O)C(=O)N1CCN(C(=O)C2=CC(F)=C(Cl)N=C2Cl)C[C@@H1]1C#N COC1=CC=C([C@H1](C)C(=O)N2CCC[C@@H1](N(C)C(=O)C3=N[NH1]C(=N)S3)C2)C=C1F CSC1=NC=C(C(=O)NC[C@@H1]2CCCN2C(=O)C3=COC(=O)C4=CC=CC=C34)S1 CC(C)C=1ON=CC=1C(=O)N2CCC=C(C(=O)N3CCC[C@@H1](CC(N)=O)C3)C2 O=C(CS(F)(F)(F)(F)F)N[C@H1](CO)CNC(=O)C1=CC2=C(C=N1)CCCC2 CCC1=NN(C)C=C1C(=O)NC/C=C/CC(=O)NC(C)(CO)CO C[C@H1](O)[C@H1](C(=O)N1C[C@H1]2CCN(C(=O)C3=COC(N(C)C)=N3)[C@@H1](C2)C1)N(C)C C=CC[C@@H1](CNC(=O)[C@@H1]1COCCN(C(=O)[C@H1]2C3C[C@@H1]4C2[C@@H1]4C3)C1)CC(C)C NS(=O)(=O)C1=CC=C(CC(=O)NC[C@]2(F)C[C@H1](NC(=O)[C@@H1]3C[C@@H1]3Cl)C2)S1 C[C@@]1(C(=O)N[C@H1]2CCC[C@@H1](NC(=O)CN3CCN(C)C(=O)C3)C2)CCNC1=O CC[C@@H1](NC(C)C)C(=O)NC1=CC=CC(CNC)=N1 CC1=CC(C(=O)N2CCC[C@](O)(CNC(=O)CN(C)C(C)C)CC2)=NC(C)=N1 COC1=CC(C(=O)NC[C@H1]2[C@@H1]3C[C@H1]2CN3C(=O)C4=CC=C([N+1](=O)[O-1])C=N4)=NC=N1 C#CCN(CCC(=O)N[C@@H1](CO)[C@@H1]1CC=CCC1)C(=O)C2=CSC(O)=N2 CC1=CC=C([C@@H1](CNC(=O)CC=2C=NOC=2)NC(=O)[C@H1](C)C3=CC=CO3)C=C1 O=C(CC1=COC(C2CC2)=N1)N3CCC4(CC3)CN(C(=O)CCC5=CN=C[NH1]5)C4 C=CCNC(=O)[C@H1]([C@H1]1[C@@H1]2COC[C@@H1]21)N3CCC[C@@H1](C4=CC=CC=C4)C3 CCC=1N=CSC=1C(=O)N[C@@H1](CNC(=O)[C@H1]2CCCC=3N=N[NH1]C=32)C(C)C CC1(CC(=O)NCCCN(CCO)C(=O)/C=C/C(F)(F)F)CCOCC1 COCCS(=O)(=O)CC1=CC=CC(S(=O)(=O)NCCS(=O)(=O)C(F)F)=C1 CSC1=CC(C(=O)N2C[C@@H1]3CC[C@H1](C2)[C@H1](NC(=O)C4(S(N)(=O)=O)CC4)C3C)=CO1 CC[C@@]1(NC(=O)C2=COC(C(F)F)=N2)CCCN(C(=O)[C@H1]3CCCN3C=O)C1 C#CCOC1=CC=C(C(=O)N2CC(F)(CNC(=O)C=C3CC[C@H1](C)C3)C2)C=C1 C#CCCCOCC(=O)N1C[C@H1](C)[C@H1](NC(=O)C2=CC=CC(C(=O)C3CC3)=C2)C1 COC1=CC=NC(C(=O)N[C@@H1](CO)CNC(=O)[C@@H1]2CCC3=CC(Cl)=CC=C32)=C1 C[C@H1]1C[C@]1(C#N)C(=O)N2CCC3=CC=C(C(=O)NCCCC4=NN=CS4)N=C3C2 C[C@H1]C1[C@H1](N2N=C(Cl)C=C(C(F)(F)F)C2=O)[C@@H1](C)O1 O=C(N[C@H1](CN1C=CN=N1)C(=O)NOC[C@@H1]2CCCO2)C3=CC=C(C(F)F)O3 C=CC1(CC(=O)N2C[C@H1]3C[C@H1]2CCN3C(=O)C4=CC=NC(C(F)(F)F)=N4)CC1 COC(=O)C1=CC=C(C(=O)N[C@H1]2C[C@@H1](CNC(=O)C3CCN(C)CC3)C2)C=C1Cl COC1=CN=CC(C(=O)NC[C@H1]2CCCN2CC3=CC=CC(C(C)(C)C)=C3)=C1 CC(C)[C@H1]1CC[C@H1](C(=O)NCC2=CCCN(C)C2)N1C(=O)C3=NS[NH1]C3=O CC(C)(C)OC(=O)[C@H1]1C[C@@]1(Br)C(=O)N2CC(CC3OCCO3)C2 CC[C@@H1](CCCC(=O)N=C1C=CN([C@H1](C)CC)[NH1]1)NC(=O)C2=CC=C(C)O2 CC(C(=O)N1C[C@H1](F)[C@H1](NC(=O)[C@@H1](C)CF)C1)=C2CCCC2 CCOC(=O)C1=CON=C1[C@H1](NC[C@@H1](C)C2=CC=C(F)C=N2)C3=NN=NN3C CO[C@H1](C(=O)N1CCOC[C@@H1](C(=O)N2CCN3CC[C@H1]2C3)C1)C4CCC4 CCN1C=CC(COC(=O)[C@H1]2CC(=O)N(C3=CC=C(F)C=C3)C2)=N1 CC1=C(NC(=O)C2=NO[C@H1](CNC(=O)C3=C(Cl)CCCC3)C2)C=NN1C(C)C CCN(C)CC(=O)NCC[C@@H1]1CN(C(=O)C(=O)C2=CC=C(C)C=C2)C[C@H1]1C CNC(=O)[C@H1](C)N(C)C(=O)[C@@]1(F)CCCN(C(=O)C2C(C)(C)C2(C)C)C1 NC1(CO)CCN(C2=NN=C(CC3CC3)N2CC4=CC=CC(Br)=N4)CC1 CC1=CC=C(CNC(=NCCCCl)N(C)CCC2=CN(C)C3=CC(F)=CC=C23)O1 COC(=O)[C@@H1]1C[C@@H1]1CNC(=O)C2=CC=CN=C2OC(C)C CC[C@]1(C(C)C)C[C@@H1]1C(=O)N[C@@H1]2C[C@H1]3CC[C@H1]2N(C(=O)COCC(F)F)C3 OC1=C(F)C=CC=C1CNC(=NCCOC[C@H1]2CCOC2)NC3CC3 C=CC(C)(C)C(=O)N[C@@H1]1C[C@H1](O)CN(C(=O)C2=CN=CC(NC(=O)CC)=C2)C1 CC1=NN(CC(=O)N2C[C@@H1]3C[C@H1]2C[C@H1]3CNC(=O)C[C@H1]4COCCO4)C(=O)O1 CSCC[C@H1](O)C(=O)NC[C@@]1(C2CC2)CCN(C(=O)C=3C(C)=N[NH1]C=3C)C1 CCCCCCN(C)CC(=O)N[C@H1]1CCN(C(=O)CC=2C=CON=2)C13CC3 CC=1N=CSC=1C(=O)N[C@H1]2C[C@](F)(CNC(=O)[C@H1]3CS(=O)(=O)CCO3)C2 CN(C)CC(=O)N1CC[C@@H1](NC(=O)C2=CC=CC(OC(F)(F)F)=C2)C[C@@H1]1C3CC3 O=C(NCCCCCCN=C1N=CC(F)=C[NH1]1)[C@@H1]2CCOC3(CCOCC3)C2 COC=1C=C(C(=O)NC[C@@H1]2CCCCCN2C(=O)CN3CCC[C@H1]3CO)N(C)N=1 CC(=O)N[C@@H1]1[C@@H1]2CC[C@H1]1N(C(=O)[C@@H1]3CCC4=NN=C(O)N4C35CCC5)C2 CC(=O)N1CCOC[C@H1]1C(=O)N2CCN(C)[C@H1](CNC(=O)C=3[NH1]N=NC=3C)C2 CC(C)[C@@H1](NC(N)=O)C(=O)N1C[C@H1](NC(=O)[C@@H1]2CCNC(=O)C2)CC3(CCC3)C1 CCC(F)(F)CC(=O)N[C@@]12CC[C@@H1](C1)N(C(=O)CCSC3=CC=C(C)C=C3)C2 CCCC(=O)N1CCC[C@]2(C1)CN(C(=O)[C@@H1](F)C3=CC=C(C)C=C3)CCO2 C#CCCCCC(=O)NC[C@@H1]1CN(C(=O)[C@@H1](O)CCSC)[C@@H1]2CCCC[C@H1]12 O=C(NC1=NC=C(CC2CC2)S1)N3CCC[C@H1](C4=CC(O)=N[NH1]4)C3 C[C@H1](N=C1C=CC(C2=CC=C(Br)S2)=N[NH1]1)C3=CC(Br)=CN=C3Br CC1=CC(C(=O)N2CC[C@H1](C(C)(C)NC(=O)C3=CN(C4CC4)N=N3)C2)=C(C)C=N1 COC1(CNC(=O)[C@@H1]2CO[C@@H1](C)C2)CN(C(=O)C3=CCCOCC3)C1 COCCOC1=CC=CC(CNC(=O)N2CCC(C)(C)[C@@H1]3CCC[C@@H1]32)=C1 C[C@@H1](CCNC(=O)C1=COC(C2CCCC2)=N1)NC(=O)[C@H1]3CCS(=O)(=O)N3C CCC=1C=C(CCNC(=O)[C@H1]2CCN(C(=O)[C@@H1]3SCC=C3C)C24CCC4)ON=1 CCCC(=O)N1CCC[C@@]2(NC(=O)CCC3=CC=CC=C3F)C[C@@H1]2C1 CO[C@H1](C(=O)N[C@]1(C)C[C@H1](C(=O)NCC[C@@H1]2CCC[C@H1]2O)C1)C(C)C C[C@@H1](CN1CCCCC1)C(=O)N2CC3(C[C@H1](NC(=O)CCC4=CN=C[NH1]4)CO3)C2 C[C@H1](CC1CCC1)C(=O)N2C[C@H1]3CC[C@H1]2[C@@H1]4CN(C(=O)[C@H1](O)CC(C)(C)C)C[C@H1]34 CCN1N=CC=C1CN2CC(C(=O)NC3=NC4=C(S3)CCC[C@@H1]4C)C2 COC1=CC=CC([C@H1](C)C(=O)N2CC[S@](=O)C(C)(C)C2)=C1 CCN(CC)[C@@H1](C)CNC(=O)CC[C@H1]1CCCCN1C(=O)CC(C)(C)C(=O)OC O=C(C#CC1=CC=C(Br)C=C1)NC2=CC=CC(F)=C2F CC=C[C@H1](O)C(=O)N(CCNC(=O)C1=CC2=C(S1)CC[C@H1](C)C2)CCOC CC[C@H1](CCCC(=O)NCCP(C)(C)=O)NC(=O)C(C)(C)CCSC CC1=CC=C2[NH1]N=C(C(=O)N[C@H1](CO)CNC(=O)C=3C=CSN=3)C2=C1 CCN(CC1=CC=CC(F)=C1OC)C2=CC(C(=O)OC)=NC3=CC=C(OC)C=C23 C[C@H1](CNC(=O)/C(Cl)=C/Cl)N(C)C(=O)C=1N=CN2C=1CCC2 COC(=O)[C@H1](C)CNC(=O)CN(CC(C)C)C(=O)/C=C/C(F)F CC(C)(C)CCN(CC=1C=CSC=1)C(=O)C2=CC=CC3=C2OCC(=O)N3 O=C(N[C@H1]1COC[C@H1]1F)[C@@H1]2CC3(CCC3)CN2C(=O)C4=CC=C(Cl)O4 CC(=O)N1CSC[C@H1]1C(=O)N2C[C@H1]3C[C@@]3(NC(=O)C4=CC5=CC=C(Cl)C=C5S4)C2 CC1(CCNC(=O)[C@H1](C=2SC=NC=2Br)N3CCO[C@@H1](CC4CC4)C3)CC1 O=C(NC1=CC(Cl)=CC([N+1](=O)[O-1])=C1)[C@@H1]2CCN(CC3=CC=CC(Cl)=C3F)C2 CC[C@@H1](C)C1=CC=C(C2=CC=CC=C2NC(=O)[C@H1](N)C(C)C)C=C1 CC(C)OC1(C(=O)NC[C@H1](C)NC(=O)CCCNC(=O)C2CC2)CCC1 C[C@@H1](C1=CC=C(F)C=C1)N2C=C(C3(NC(=O)CCC#N)CCC3)N=N2 CC1=CSC(C(F)(F)C(=O)N2CC[C@@](C)(CNC(=O)C=C3CCCC3)C2)=N1 CN(C(=O)CNC1CC1)[C@H1]2CCN(C(=O)C3=CC(F)=C(C(F)F)C=C3F)C2 COC1=NC=C(C)C=C1C(=O)N2CCO[C@H1](CCCNC(=O)[C@H1](F)OC)C2 CC1=NO[C@@H1](CNC(=O)NCC2=CC=C(N3CCCCC3)C=C2)C1 N[C@@H1](C(=O)NC1=NC=NC(Cl)=C1I)[C@H1]2CCCOC2 CC1(C)[C@H1](CC(=O)NCC23CCCN2CCC3)C[C@H1]1NC(=O)CC4=CC=NS4 CC(C)C=1OC=NC=1C(=O)N2CC[C@]3(CCCN3C(=O)[C@H1]4CCC[C@H1](C)CC4)C2 CCCN(CCNC(=O)C1=CCOCC1)C(=O)CN2C=CC(O)=NC2=O C[C@H1](C(=O)NCCC1(O)CN(C(=O)CCOC2=CC=C(N)C=C2)C1)[C@@H1]3CCOC3 C[C@@H1](O)C(=O)N[C@H1]1COC2(C1)CN(C(=O)CC3=CC4=CC=CC=C4S3)C2 C#CC1=CN=C(C(=O)N2CCCC[C@@H1](NC(=O)C3=CC(C(F)F)=NO3)C2)C(C)=C1 C#CC1=CC=C(C(=O)N2C[C@H1]3CCN(C(=O)[C@H1](C)C(=C)C)[C@@H1](C3)C2)C=C1Cl CCN1N=NC(C)=C1C(=O)NCC2(CN3C=C(C4=CC(C)=CC=N4)N=N3)CC2 C=C(C)CCC(=O)N[C@]12CC[C@@](CNC(=O)[C@@H1](CC3=CC=CC=C3)OC)(C1)OC2 CO[C@H1]1C[C@@H1](CN=C(N[C@@H1]2C[C@@H1]2C)N3CCCN(S(=O)(=O)N4CC(O)C4)CC3)C1 COCCC(C)(C)CC(=O)N[C@]12C[C@H1]1CN(C(=O)C=3C=C(C)N(CCO)N=3)C2 COCCO[C@H1](C)C(=O)NC1=CC=C(NC(=O)C[C@H1](C)C2=CC=CC=C2F)C=C1 COCC1=NC=C(C(=O)N[C@H1]2CCN(C(=O)CN3C=NC=C3C)C[C@@H1]2CO)S1 CC1(C)CC[C@@H1](CC(=O)OC2=CC=CC=3C=C[NH1]C2=3)C4=CC=CC=C41 CCC1=CC=CC(C(=O)NCC(C)(C)CNC(=O)[C@H1]2CN(C)C[C@@H1]2CC)=C1F C[C@H1](C[C@H1]1CCCO1)C(=O)NCC2(CN(C)C(=O)C3=NN=C(S)N3C)CC2 CC[C@H1](C)CC(=O)C(=O)N1CC[C@]2(C(=O)N[C@H1](CC)C3CC3)CCC[C@H1]12 CN1N=C(O)C=C1C(=O)N[C@H1](C(=O)N2C[C@@H1](CO)C3(CC3)C2)[C@@H1]4CCCO4 C[C@@H1]1CN(C(=O)[C@@H1]2CCCN(C)C2)CCN1C(=O)C3CCC4(CCCCC4)CC3 COC1=CC=C(CN2CC[C@H1](CNC(=O)C3=CC(OC)=NC=C3F)C2)C=C1Cl CC(C)C1=CC=C(C(=O)NC23CC(NC(=O)C4=CC=CC(C#N)=C4Br)(C2)C3)C=C1 CCN1CC2(C1)CN(C(=O)CCC3(NC(=O)CN4CCOC4=O)CCCC3)C2 CC1=CSC(C(=O)NC(C)(C)CNC(=O)C(C)(C)CO)=C1C CCC[C@H1]1CC[C@H1](C(=O)N2C[C@H1]3CCC[C@@]3(NC(=O)C4=CC=NN=C4C)C2)CC1 C[C@H1]1CCCC[C@@]1(CNC(N)=O)NC(=O)C(=O)N2CCCN3[NH1]C=NC3C2 C[C@@H1](NC(=O)C#CC(C)(C)C)[C@@H1]1CCCN(C(=O)C2=NC3=C(Br)C=NC=C3[NH1]2)C1 COCCC1(C(=O)N[C@H1]2CCCC[C@H1]2NC(=O)C[C@H1]3OCC4=CC=CC=C43)CC1 CC1=CC(O)=NC=C1C(=O)N2CC[C@H1]3CN(C(=O)[C@@H1]4C[C@@H1](C)CCO4)CC[C@@H1]3C2 C[C@H1](CNC(=O)C1=CC=C2C(=C1)C=CS2(=O)=O)CNC(=O)[C@@H1]3CCC[C@H1](CF)C3 O=C(C=CCO)N[C@@H1]1CCC[C@H1](NC(=O)C2=CC(C3CCC3)=NO2)C1 C#CCCC(=O)N1C[C@H1](C)C[C@H1]1C(=O)NC2=CC(Cl)=CC(C)=C2Cl CCOC1=CC=C(C(=O)N[C@H1](CNC(=O)CC2=NN=CN2C)C(C)(C)C)C=C1C CCN1C(C(=O)N2C[C@H1](N(C)C(=O)[C@H1](CC(C)C)NC(N)=O)C(C)(C)C2)=CN=C1O CCC(=O)N[C@@H1](C)C(=O)NC1[C@H1]2COC[C@H1]1CN(C(=O)[C@@H1]3COC(=O)O3)C2 O=C(NC1=CC=CC(F)=C1C(=O)NC2=CC=C3C(Br)=N[NH1]C3=C2)C4=CC=CC=N4 COCCOCC=CC(=O)N1CC[C@@](NC(=O)C2=NOCC2)(C3=CC=CC=C3)C1 CCN(CC)CC(=O)NCC[C@@]12CC[C@@H1](C1)N(C(=O)C3=CC=CC(F)=C3NC)C2 CC=1[NH1]C(C)=C(C(=O)N2CC3(CC[C@H1](CNC(=O)[C@H1]4C[C@H1](O)C4)O3)C2)C=1C O=C(CC1CCOCC1)N[C@H1](CC2=CC=CO2)C(=O)N3C[C@H1]4C[C@H1]3C(F)(F)C4 O=C(NCC[C@@]12CCC[C@H1]1C2)N3CCN(S(=O)(=O)C4=CC=C5C(=C4)CCC5)CC3 CC(=C(F)C(=O)NC[C@H1](O)CN(C)C(=O)[C@@H1]1CCN1CCC2=CC=CC=C2)CC CCC(=O)N[C@H1](C)C(=O)N[C@H1](C(=O)N1CCCC[C@@H1]1C(=O)OC)C2=CC=CO2 CC1=CC=NC=C1CCNC(=O)C2(NC(=O)COC=3C=CSN=3)CSC2 COC(C)(C)CCC(=O)N[C@@H1]1CCN(C(=O)[C@H1]2CC[C@H1]3C[C@H1]32)[C@@H1](C4CC4)C1 CC=1OC=CC=1CC(=O)N2CC[C@@H1](NC(=O)CCC=3C=CSC=3)C2 CCCC1=CC=CC(NC(=O)C[C@H1](C)C(C)(C)NC(=O)[C@@H1](C)SCC)=C1 CS(=O)(=O)C=1C=NN(CC(=O)N2C[C@@H1](NC(=O)C3(O)CCC3)[C@H1](C4CC4)C2)C=1 CCC(CC)N(C)CCC(=O)N1C[C@@H1]2CC[C@H1](C1)N2C(=O)C3=CC(OC)=NN3C COCCN(CC(C)C)C(=O)[C@@H1]1C[C@H1](NC(=O)[C@@H1]2CC(=O)N(OC)C2)CCO1 C#CC#CC(C)(C)NC(=O)C[C@@H1]1CCC[C@@]12NC(=O)NC2=O CC(C)NC(=NC[C@@H1](C)C(F)(F)F)N1CC[C@@H1](C(F)(F)F)C1 CC(C)=C(Br)C(=O)NC1[C@H1](C)CN(C(=O)C2=CC=C3OC(O)=NC3=N2)C[C@H1]1C CC(C)(CC[C@H1]1CCCCN1C(=O)C[C@@H1](O)C2CCCC2)NC(=O)C3CCCC3 C[C@H1](NC(=O)C=1C=C(I)ON=1)[C@@H1]2CCCCN2C(=O)C3=CC=CC=[N+1]3[O-1] C#CC1(OCC(=O)N2CCC3(CC2)C[C@H1]3C(=O)NC(C)(C)CC(C)C)COC1 CC1=CC(C(=O)N2CC(NC(=O)C3=CC4=C(C=NN4C)N=C3O)C2)=CC(F)=C1C C=CCCCC(C)(C)CN[C@]1(C2=NN=NN2C3CC3)CN4CCCC[C@H1]4C1 C#CCC1(C(=O)NC[C@@]23CCC[C@@H1](CN2C(=O)C(C)(Cl)Cl)C3)CCCCC1 COC1=C(Cl)C=C(C(=O)N[C@H1]2CN(C(=O)C3CC(=C4CC4)C3)C[C@H1]2C)N=C1Cl CO[C@H1](C(=O)N(C)C[C@@H1](C)CNC(=O)CN1N=CN2C=CC=C2C1=O)C(C)(C)C CC(C)(C)OC(=O)N[C@H1](CNCC=1C=N[NH1]C=1)C2=CC=CC(C(F)(F)F)=C2 CC1=CC=CN2C(C(=O)N3CC(CCCCNC(=O)C4=NC=CS4)C3)=CN=C12 O=C(N[C@H1]1COCC[C@H1]1NC(=O)C=2C=CSC=2)C3=CC=C(Cl)C(Br)=C3 C=C[C@]1(C(=O)N[C@H1](C(=O)NC)C2CC2)CCN(C(=O)[C@@H1]3CCC[C@H1](O)C3)C1 CC(C)=CCN[C@@H1](C1=CC(F)=CC(C#N)=C1)C2=NN=NN2C3(C)CC3 CNC(=O)N1CC[C@H1](C(=O)NC[C@]2(C)CCCN2C(=O)CSC3=CC=NC=C3)C1 COC(=O)C1=CC[C@H1](NS(=O)(=O)C2=CN=C(Cl)N2C)C1 CN(C)CCCCC(=O)NC1([C@H1]2CCN(C(=O)C3=COCCC3)C2)CC1 CN1CC=CC[C@H1]1CC(=O)N[C@@H1]2CN(C(=O)C3=CC(C(N)=O)=CS3)CC(C)(C)C2 CCCCCC(=O)N1CC[C@H1]2[C@H1](CCCN2C(=O)CN3C=C(C)C=N3)C1 O=C(C1=CN=CC=C1C2OCCO2)N3CC=C(Cl)C3 COC[C@@H1](C)[C@H1](C)C(=O)N[C@@H1]1C[C@H1]2CC[C@@H1]1C[C@H1]2NC(=O)C3=CC=CC=N3 O=C(CC1=CC=C(Br)C=C1)N[C@@H1]2C[C@@H1](F)CN(C(=O)C(Cl)(Cl)Cl)C2 CC[C@@H1](O)C(F)(F)C(=O)N(C)CCNC(=O)C[C@@H1](C)OC CC1=CSC(C)=C1C(=O)N2CCCC[C@H1]2CNC(=O)CC=3C(C)=NN(C)C=3C CC1(CC(=O)N2CCN3N=C(CNC(=O)C4=CCCSC4)C=C3C2)CCC1 CCCCC(=O)N[C@@H1]1CCN([C@H1](C)C(=O)NCC2=CC=CC=C2F)CC1(C)C COCCCNC(=O)[C@@H1](C=1C=NN(C2=CC=CC=C2)N=1)N3CC[C@@](O)(C(C)C)C3 C=CCC1(C(=O)N2CCC[C@H1](CN=C3[NH1]C(Cl)=NC=4C=C(C)SC3=4)C2)CC1 CCCN1CCC(C(=O)N2C[C@@H1](CNC(=O)CC3=CC=C(F)C=C3)C[C@H1]2C)CC1 CCN1C=C(C(=O)N[C@H1]2CN(C(=O)[C@H1](C)OCC(C)C)C[C@@H1]3C[C@@H1]32)C=N1 C#CC[C@]1(C(=O)N[C@H1]2CCC[C@H1]2NC(=O)CN3CCC(CO)CC3)CCCO1 COC1=C(NC(=O)NCC[C@@H1](C2=CC=CC=C2)C3=CC=CO3)C(C(F)(F)F)=NN1C C=CC[C@@H1](NC(C)=O)C(=O)N1CC(N(C)C(=O)C=2SC([C@@H1](C)OCC)=NC=2C)C1 O=C(CNC(=O)C1=NC=CC=C1Cl)NC[C@@H1]2CCCOC2 CNS(=O)(=O)CCC(=O)N[C@](C)(CNC(=O)C1=CN(CCC2CC2)N=N1)C(C)C CCCN1N=C(C)C=C1[C@@H1](NCC2=CC=CC3=NSN=C23)C4=NN=NN4C5CC5 CCN(CC)CC(=O)N[C@@H1]1C[C@H1]2C[C@@H1]1CN(C(=O)[C@@H1](F)CC3=CC=CC=C3)C2 O=C(O[C@H1]1CCCN(C(=O)C#CC2CC2)C1=O)[C@@H1](O)CC3=CC=CC=C3 CC1=CC(C(F)(F)F)=CC=C1N(C(=O)C2=C[NH1]C=C2C)[C@@H1]3[C@H1](C)OCC34CCC4 CC(=NO)[C@@H1]1C[C@H1](C(=O)N[C@H1]2CC[C@]23CCCN(C(=O)[C@@H1]4C=CCC4)C3)C1(C)C CN1N=CC=C1C=CC(=O)NC[C@@H1]2CN(C(=O)C=CI)CC[C@]23CCOC3 CN1N=C([N+1](=O)[O-1])C=C1C(=O)N[C@]2(C)C[C@@H1](NC(=O)C[C@@]3(C)CCCO3)C2 COC[C@H1](O)C(=O)N(C)C[C@@H1](O)CN(C)C(=O)CCCOC1=CC=C(Cl)C(C)=C1 CCC[C@@H1]1COCCN1C(=O)[C@@H1]2C=CCN2C(=O)[C@H1](C)OCCOCC C#CC[C@H1](C)C(=O)N1C[C@@H1](NC(=O)C2=CC(O)=CC(F)=C2F)CC(C)(C)C1 CCN(C[C@H1](C)NC(=O)C1=COCCO1)C(=O)CN2C(=O)CN(C)C2=O C#CCOCCOCC(=O)N1C[C@H1]2OCCN(C(=O)C=3[NH1]C=NC=3C)[C@@H1]2C1 C[C@H1](NC(=NC[C@H1]1CCOC1)NCC2CC2)C3=C(Cl)C=CC=C3Cl CCC(=O)N[C@@H1](C)C(=O)N1C[C@H1](CNC(=O)C=2C=NN(C)C=2SC)C3(CC3)C1 CC1=CC(C(=O)N2CCC3(C2)CN(C(=O)[C@H1]4CCN(C)C4)C3)=C(C)[NH1]1 CCCC[C@@H1](CNC(=O)C1=CC2=C(O)C=CC=C2[NH1]1)NC(=O)[C@H1]3CCC(C)(C)C3 CCN1C(C(=O)NC(C)(C)CC(=O)NCC2=CC(C3CC3)=NO2)=CN=C1O C#CC1=CN(C)N=C1C(=O)N[C@@H1](CCC=C)C(=O)N2CC(C3=NC=C[NH1]3)C2 CC[C@]1(C(=O)N2CC3CC2(C(=O)N(C)[C@H1]4CCOC4=O)C3)CCOC1 C#CCCN1CCN(C(=O)C2=N[NH1]C=C2CNC(=O)C[C@@H1]3CCC[C@@H1](O)C3)CC1 CC(C)C[C@@H1](CNC(=O)C(F)F)NC(=O)C1=C(O)C=CC(Br)=C1Cl CC[C@H1](C(=O)N[C@H1]1CCCN(CC2=NC(O)=C3SC=CC3=N2)CC1)[C@H1](C)O CC(=CC(=O)N[C@H1](C)C[C@H1](C)NC(=O)[C@]1(C)CCO[C@H1](C)C1)C2=CC=CC=C2 O=C(N[C@@H1]1CN(C(=O)C=CC2=CSC=N2)C[C@@H1]1F)C3=CC=C(F)C(C(F)(F)F)=C3 CCCC1=CC(C(=O)NC[C@@H1]2CN(C(=O)C3=CN=NC(Cl)=C3)CCO2)=CC(O)=N1 CC1=NOC2=CC=C(NC(=O)[C@@H1]3C[C@@H1](F)CN3CC4=CC(F)=CC(Cl)=C4O)C=C12 COC=1C=C(C(=O)NC(C)(C)CCNC(=O)[C@H1]2C[C@@H1]2[N+1](=O)[O-1])SN=1 CCN1CC[C@H1]1C(=O)N2CC[C@H1](OCC(=O)NC3=CC(C#N)=CN=C3C)C2 CN(C)S(=O)(=O)[C@@H1]1CCN([C@@H1](C(=O)NC2CC2)C3=CN=C(C4CCC4)S3)C1 C[C@@H1](CCNC(=O)[C@H1]1CCC(=O)N1)NC(=O)[C@H1](O)C2=CC=CC=N2 C=C[C@]1(C(=O)N[C@H1]2CCCC[C@H1]2N=[N+1]=[N-1])CCN(C(=O)[C@H1](F)CCCC)C1 CC1=CC=C(NCC(=O)NC[C@H1]2C[C@@H1](C)N(C(=O)CC3C(C)(C)C3(C)C)C2)C=C1 CNC(=O)CCC(=O)N1CC2=CC=CC=C2[C@H1](NC(=O)[C@]3(O)CCOC3)C1 O=C(C[C@@H1](O)C1CCCC1)NCC2(C(=O)N3C[C@@H1](C(N)=O)C4(CC4)C3)CCCC2 O=C(CC1=CSC=N1)N[C@@H1]2C[C@H1]2NC(=O)C=3N=C(Br)SC=3C4CC4 CC1=CCS[C@@H1]1C(=O)N[C@H1]2[C@H1]3C[C@@H1]4[C@H1]2[C@@H1]4[C@@H1]3C(=O)NN5C=NC6=CC=CC=C65 C[C@H1](OC1=CC=CC(Br)=C1)C(=O)NC2(CN(C)C(=O)CC#N)CC2 O=C(N[C@@H1](CO)CN1CCCCC1)[C@H1](C2CCOCC2)N3CC=CCC3 CN1C=CC(C(=O)N2CC[C@@H1](NC(=O)C3=CCCS3)C2)=CC1=O CN1N=C(C2CC2)C=C1C(=O)N[C@H1]3CCN(C(=O)C4=CC=CN(O)C4=O)C[C@@H1]3F COC1=CC=CC(C2(C)CCN(C(=O)C(C)(C)SC)CC2)=C1 CC[C@@H1](CC(=O)N[C@@H1](C)C1CC(NC(=O)C2=NC=CN3C=CN=C23)C1)CN(C)C COC(=O)[C@H1]1C[C@@H1]1C(=O)NC2=CC(C(C)C)=NN2C CC(C)C1=CC=C(C(=O)N2CC3CC2(CNC(=O)C=CC4=CC=C(Cl)C=C4)C3)S1 O=C(C1=CC=C(C(F)F)N=C1)N(CC2=CC=C(CO)O2)C3CC4(CNC4)C3 CC1=CC=CC2=C1O[C@H1](C(=O)NC[C@H1]3C[C@H1]3NC(=O)C4=C(Cl)CCCC4)C2 CC=1C=NSC=1C(=O)N2CC[C@@]3(C[C@H1]3C(=O)NC[C@@H1]4NC(=O)NC4=O)C2 COCC[C@@H1](CNC(=O)C1=CC=C(S(N)(=O)=O)S1)NC(=O)C2=NN=C(O)N=C2O CC1=NOC(COCC(=O)NCCC(C)(C)NC(=O)C[C@@H1]2CCC[C@H1](O)C2)=N1 C[C@H1]1[C@H1](NC(=O)C2=CN=CS2)[C@H1](C)CCN1C(=O)C3=CN=CC(F)=C3 CC1=CC([N+1](=O)[O-1])=CN=C1N2CC[C@@](O)([C@H1](C)NC(=O)C3=CC=C(Cl)C=C3Cl)C2 C[C@H1](C(=O)N[C@H1](C(=O)NC[C@@](C)(O)C(F)F)C1CCCC1)C2=CN=CN=C2 O=C(CSC(F)F)NC1CC2(C1)C[C@H1]2NC(=O)[C@@H1]3C[C@H1]3C4=CC=CC=C4 CS[C@@H1](C(=O)N[C@@H1](C)CN(C)C(=O)C[C@H1]1NC(=O)CNC1=O)C(C)(C)C CC1=CC(CCC(=O)N2CC[C@@H1](C)[C@H1]2CNC(=O)C3=N[NH1]C=C3C(C)C)=NN1C C=CCCC(C)(C)CNC(=O)C12[C@@H1](NC(=O)CCCC(OC)OC)C3C[C@H1]1[C@H1]2C3 C[C@]1(C(=O)O)CN(C(=O)NC2=CC=CC(C3=CC=CC4=C3CCCC4)=C2)CCO1 O=C(NC1(CF)CN(C(=O)C[C@@H1]2CC3(CCC3)CO2)C1)C4=CCCCCC4 CCC1=C(C(=O)N[C@]2(C(=O)NCC3=CC(Cl)=CC=N3)CCC[C@H1]2C)C=NN1C CC=1N=C(O)[NH1]C=1C(=O)N[C@H1](C)C2CCN(C(=O)[C@H1](C)C(C)C)CC2 CCC=1C=C(C(=O)NC[C@@H1]2CC[C@@H1]2NC(=O)CN3N=CC(Br)=N3)ON=1 CN(CCCO)S(=O)(=O)C1=CC=C(Br)C=C1N2CC[C@@H1](C(F)F)C2 CCC1=CC=C(F)C=C1C(=O)NCCCC(C)(C)NC(=O)[C@H1](C)CCCOC CCCN1N=C(C(=O)N2C[C@H1](CO)[C@@H1](C3CC3)C2)C4=CC=CC=C41 CC1=CC=C([C@@H1](C)C(=O)N2CC[C@@H1](N=C3N=C(Cl)C4=C([NH1]3)COC4)C[C@H1]2C)S1 C=CC(C)(C)CNC(=O)[C@H1](CCC1CC1)NC(=O)CCCCC COC[C@@]1(C(=O)NCC2(CNC(=O)C34CC(CCO3)C4)CC2)C=CCC1 C[C@H1](O)C1=CN(CC(=O)N2CC(N(C)C3=NC(C#N)=NC=C3Cl)C2)N=N1 COC1=CC=CC(C)=C1C(=O)NC[C@H1](O)CN(C)C(=O)[C@H1]2C[C@@H1]2C C[C@@H1]1OCCN(C(=O)CCCN2C=CC=N2)[C@H1]1C(=O)NCC3=CN=CC(Cl)=C3 BrC1=CC=C(CN2N=C(C3=CC=CO3)N=C2C4=CC=NN4CC5CCC5)C=C1 C[C@H1]1[C@H1](NC(=O)C2=CON=C2C3CCC3)CCCN1C(=O)C4CC4C CN1CC(C(=O)N2CCN3C(=O)[C@H1](NC(=O)C4=CSC5=NC=CN45)C[C@H1]3C2)C1 N#C[C@@H1]1CN(CC2=CC=CC=C2Cl)C[C@@H1]1NC(=O)C3=C(Br)C=CC(F)=C3F CC1=CC(=NC(=O)[C@H1]2CCN(C(=O)CCC3CC(C)C3)C24CC4)[NH1]N1C(C)C CC[C@](C)(C(N)=O)C(=O)NC1CCC2(CC1)CN(C(=O)C[C@@H1]3C=CCCC3)C2 C#CCN1C=CC=C1C(=O)NC[C@H1]2C[C@@H1](OC)CN2C(=O)C3=CN=C(C)C(N)=C3 CCCCCCCCOCC(=O)N[C@H1]1C[C@@](C)(NC(=O)[C@@H1](C)[C@@H1](C)CC)C1 C[C@@H1]1CCN(C(=O)C2=CC=C([N+1](=O)[O-1])[NH1]2)C[C@H1]1CNC(=O)CC3CCCCCC3 C=CC=1C=NN(C)C=1C(=O)N[C@H1]2CC[C@H1](NC(=O)CC3(OCC)CCC3)CC2 CCC[C@H1](NC(C)=O)C(=O)N[C@@H1]1CC[C@H1]2CCN(C(=O)COCC3CCC3)[C@H1]1C2 C=CCC1=CC(C(=O)NC[C@@H1]2COC[C@H1]2NC(=O)C[C@H1]3CC(C)=NO3)=CC=C1F COCC[C@@H1]1C[C@H1]1C(=O)NC[C@@H1]2CCN(C(=O)C3=CN=C(OC)C=C3C)C2(C)C CCN(CCNC(=O)C1=CC=C(CCN(C)C)C=C1)C(=O)CCC=2C=CN(C)C=2 CCS[C@@H1](C)C(=O)NCC[C@@]1(C)CCN(C(=O)C2=NC=C(Cl)C=C2F)C1 CO[C@@]1(C(=O)N2CC(CCNC(=O)CCN3CCCC[C@H1]3C)CC2)CCSC1 CC[C@H1](O)C(=O)NCCCCCC1CCN(C(=O)C=2SC=CC=2F)CC1 C=C(C)CC(=O)N(C)C[C@@H1](O)CN(C)C1=CC=C(S(C)(=O)=O)C=C1[N+1](=O)[O-1] CC(=O)OC1(C(=O)N2CCC(N(C)C(=O)[C@@H1](C(C)C)N3C=NN=C3)CC2)CC1 COC1=NSC=C1C(=O)N2CCC[C@H1](NC(=O)C3=CC=CC(Cl)=C3F)[C@H1](F)C2 C[C@H1](OCC(F)(F)F)C(=O)N1CCC2(CC1)C[C@H1]2CNC(=O)C=3C=CSC=3 CC1(CCNC(=O)[C@@H1](NC(=O)CNC(=O)C(C)(C)C)C2CC2)CCCC1 CC(=O)NC1=CN=CC=C1C(=O)N2C[C@H1]3C[C@H1](NC(=O)C(C)(C)C4CCC4)[C@H1]2C3 CC#CCCC(=O)N1C[C@@H1](CNC(=O)C2=CN(C(F)F)C=N2)[C@@H1](C(F)(F)F)C1 CN1N=C(C(=O)NC[C@H1](NC(=O)C2=CC(F)=CC([N+1](=O)[O-1])=C2)C3CCC3)C=C1O CSC[C@H1](O)C(=O)N1CCC[C@@H1]1C(=O)N2CCO[C@H1]3[C@H1](O)C[C@H1]32 C#CC1=CC=CC(OCC(=O)NC[C@@H1](C)CN(C)C(=O)[C@@H1]2C[C@@H1]2C(F)F)=C1 CN(C(=O)C1COC1)[C@@H1]2CCCN(C(=O)[C@H1]3CCN(C)C[C@@H1]3C=4C=NN(C)C=4)C2 CC(C)[C@@](F)(CNC(=O)[C@H1](C)O)C(=O)N(C)CC=1N=C[NH1]N=1 O=C(C[C@H1]1[C@@H1]2CN(C(=O)C3(C4=CC=NO4)CC3)C[C@H1]12)NCC56CC(F)(C5)C6 CCCOC1(CNC(=O)CCN2CCCC2=O)CCCCC1 N#CCN1C=CC(C(=O)N2CC[C@H1](NC(=O)COC(F)(F)F)[C@@H1](CO)C2)=N1 CC1=CCCN(C2=NC3=CC=CN=C3C(=N[C@H1](C)C[C@@H1]4CCOC4)[NH1]2)C1 CC(C)N1N=CN=C1C(=O)N[C@@H1](C)CCCCNC(=O)C2=CSN=C2Cl COC[C@@]1(C)C[C@H1](NC(=O)CCCC#N)CN1C(=O)C2=CC=C(OC(F)F)N=C2 C[C@@](O)(CNC(=O)C1=CN=CS1)CNC(=O)[C@@H1]2C[C@H1]2C(F)F CC1=NC(C)=C(C(=O)N2CCOC[C@@](F)(CNC(=O)C=3C=CSC=3C#N)C2)[NH1]1 CC[C@H1](CCO)CNC(=O)[C@@H1]1CSCN1C(=O)C(C)(C)CCOC CC1=NC=C(CN2CCC[C@@H1](C(=O)N3C[C@H1]4CNC(=O)[C@H1]4C3)C2)C=N1 C#CCCC[C@H1](C)C(=O)N1[C@@H1](C)C[C@@H1]1C(=O)NCC2=CN=CN2CCC CC1=NOC(C)=C1/C=C/C(=O)N2CCC3(CC2)CN(C(=O)C(C)(C)C#N)CCO3 C[C@@H1](NC(=O)[C@@H1]1C[C@H1]1C2=CC=CC(F)=C2)[C@@H1]3CCCN3C(=O)C4=CC=C(O)N=C4 CCO[C@@H1]1CN(C(=O)CN2C=CN=N2)C[C@H1]1CNC(=O)[C@H1]3CCCNS3(=O)=O CC1=NC(Cl)=NC(N2[C@H1]3CC[C@H1]2CN(C(=O)[C@H1](C)C4=CC=CC(Cl)=C4)C3)=C1Cl CC1(CC(=O)NC[C@@H1]2C[C@H1]3CC[C@H1]2N(C(=O)[C@]4(C#N)CCCO4)C3)CC1 CC1=CC=CC=C1C2(C(=O)NC3CCC(NC(=O)[C@H1]4OCC[C@H1]4C)CC3)CC2 O=C(C[C@H1]1C=C[C@@H1](NC(=O)[C@H1]2C[C@@H1]2[N+1](=O)[O-1])C1)NC3=CC(O)=CC(F)=C3 CC=1C=CSC=1C(=O)N[C@@H1](C)C(=O)N[C@@H1]2CN(C)C(=O)C23CC3 CCC1=NC(C2=NC(CSC)=NN2CC3=CC=C(Cl)C=C3)=NN1C4=CC=CC=C4 C[C@@H1]1CC2=CC(F)=CC=C2CN1C(=O)C(=O)N[C@@H1]3CCN(C4CCNCC4)C3=O CN(C(=O)[C@H1]1CCC1(F)F)C2CC(NC(=O)C=CCOC3CCOCC3)C2 CCCC(CCC)C(=O)NC[C@@H1]1CO[C@@H1](CNC(=O)[C@@H1]2CCCC3(CC3)C2)C1 C[C@H1](NC(=O)COC1COC1)[C@H1]2CCN(C(=O)C3(C4=CC=C(F)C=C4)CCC3)C2 C[C@H1]1CC(C(=O)NCC[C@@H1]2CCCN(C(=O)C3=CN(C)C(=O)C=N3)C2)=NO1 CCCCC[C@@H1](C(=O)N[C@H1]1CC[C@H1](NC(=O)C2=CC=C[N+1]([O-1])=C2)CC1)C(C)C CC(C)(C(=O)N1CCO[C@@H1](C=2N=C[NH1]N=2)C1)C3=CC=CS3 CC1=CC(C)=C(CC(=O)NC[C@H1]2[C@@H1]3CN(C(=O)[C@@H1](C)SC4=NN=CN4C)C[C@H1]23)S1 C[C@@H1](NC(=O)COC1=CC=C(Cl)N=C1)C2(CNC(=O)CCC=3N=C[NH1]N=3)CC2 COC1=CC=C(C(=O)O)C=C1CN2C[C@@H1]3[C@H1](CCN3C4=NC=NC5=C4CC(=O)N5)C2 CN1CCN(CC(=O)N2C[C@@H1]3C[C@H1]2C[C@H1]3CNC(=O)C4=CC=C(CO)O4)CC1 CC(C)[C@H1](C)CC(=O)N1CC(C=2OC=NC=2CNC(=O)C(F)(F)C34CC(C3)C4)C1 CC(C)N(CCNC(=O)C=1N=NSC=1C2=CC=CC=C2)C(=O)[C@H1]3CC[C@@H1](C)S3 C[C@@H1]1C[C@H1]1C(=O)N2[C@H1]3CC[C@H1]2CN(C(=O)[C@H1]4CCCC(F)(F)CC4)C3 O=C(CC1=CC=C(O)N=C1)NC[C@H1]2[C@H1](O)[C@H1](O)CN2C(=O)C3=CC=C(CO)C=C3 O=C(CSC1=CC=NC=C1)N[C@@]2(CF)CCN(C(=O)CC3=CC=CC=C3Cl)C2 COC1=CC=NC(N2CCC[C@@H1]3CN(C(=O)[C@@H1](F)C(C)(C)O)CCC[C@@H1]3C2=O)=N1 CS[C@H1](C(=O)NC[C@H1](CO)NC(=O)C1=CN=CC(N)=C1C)C2=CC=CC=C2 C#CCSCC(=O)N(CC)C[C@H1](C)NC(=O)C1=CC(C2=CC=NC=C2)=NO1 CC1(C)CC(C(=O)NCCCCNC(=O)[C@@H1]2CC(=O)C3=CC=CC=C3O2)C1 CN1N=NC(C(=O)N2CCC[C@H1]3[C@H1]2CCCN3C(=O)C4=CC=C(N)C(F)=C4)=C1N CC1(CONC(=O)C[C@H1]2COCCN2C(=O)C3=CC=CC=4[NH1]C=CC3=4)CC1 CC[C@H1](O)CN1C=C([C@@H1]2CCN(C(=O)C[C@H1]3CCCNC(=O)C3)C[C@H1]2O)N=N1 CC1(C(=O)N2CC[C@@](F)(CNC(=O)CCCN3CCCCC3)C2)CCCC1 O=C(O)C1(C(=O)O)C[C@@H1]1C2=CN(CC(=O)N3CCO[C@H1]4CCCC[C@@H1]43)N=N2 O=C(N[C@H1]1CN(C(=O)C2=CC=C(Cl)N=N2)CC13CC3)C4=CN5C=CSC5=N4 O=C(CC1CCSCC1)N2CC[C@@H1]3C[C@@]32C(=O)N4C[C@]56CC[C@]5(COC6)C4 CC[C@@H1](CN(CC)C(=O)/C=C/C1=CC=CC(F)=C1F)NC(=O)[C@@H1]2CCCOCC2 O=C(N[C@@H1]1CCC[C@H1](CNC(=O)[C@H1]2CCC23CCC3)C1)C4=NC5=CC=CC=C5[NH1]4 O=C(CC1=CC=CC(Br)=C1)N2CC=C[C@H1](NC(=O)C3(C4CCC4)CC3)C2 CCCN(CC)C1=NN=C(C=2C=NN(C(C)(C)C)C=2)N1CCC3CCCC3 CC[C@H1](CCOC)C(=O)N1C[C@@H1]2C[C@H1](C(=O)N3CCOC[C@H1]3C)[C@@H1](C2)C1 CO[C@@H1](C1=CN(CCCCCC(=O)N2CCC(C)(O)CC2)N=N1)C3CC3 CC=1N=C(NC(=O)[C@@H1]2CCCCC2(F)F)SC=1C(=O)NC3=CN=NC=C3Br O[C@]1(CNCC2=CN=C3C=CSC3=C2)CC[C@@H1]OC14CCC4 O=C(C=CC1=CN=CS1)NC[C@@H1]2CCC[C@@H1]2NC(=O)C3=CN=C(Cl)S3 CCC[C@@H1](C(=O)NC1CN(C(=O)[C@H1]2C[C@@H1](NS(C)(=O)=O)C2)C1)S(N)(=O)=O COCCN(C1CCCC1)S(=O)(=O)C2=CN=C(O)C(Br)=C2 C=CCCC(=O)N[C@@H1]1C[C@H1]2C[C@@H1](NC(=O)C3=CC=C(C(F)(F)F)C([N+1](=O)[O-1])=C3)[C@H1]2C1 C=CC(=O)N1CCC[C@@]1(CNC(=O)C[C@@H1]2CC[C@@H1]3C[C@H1]3C2)COC C=CC[C@@H1](CNC(=O)C[C@H1](C)C1=CC=CC=C1C)NC(=O)C2=CC(C)=NS2 CCN(C(=O)CC(C)C)[C@@H1]1CCN(C(=O)C2=CC=C3N=C(N(C)C)[NH1]C3=C2)C1 O=C1NCC[C@@H1]1C(=O)N2CCN(CCCNC(=O)C=C(Cl)Cl)CC2 COC[C@@H1](O)CCNC(=O)[C@@H1]1CC12CCN(C(=O)C3=CN=CN3C)CC2 CN(CCCCNC(=O)[C@@H1](O)CC1=CC=CC=C1)C(=O)[C@]2(CF)CC2(F)F COCN1C=CC(C(=O)N2CCC[C@](F)(CNC(=O)C3=CN=C(S)N3C)C2)=N1 CC(=O)N[C@]1(C)CCN(C(=O)[C@]2(C)CN(C(=O)CC(C)(F)F)C(C)(C)C2)C1 CC1=NN(C)C=C1CNC(=O)[C@@H1](NC(=O)C[C@@H1]2CCC(C)(C)O2)C3(O)CCC3 C[C@H1](NC(=O)C1(C)CCC1)[C@H1]2CCCN2C(=O)C3=CC=C4[NH1]C=CC4=N3 CC1=C(CNC(=O)C2=C[C@H1](O)[C@H1](NC(=O)[C@@H1]3CCCOCC3)C2)N=NN1C CCN(OC)C(=O)[C@@H1]1CC[C@H1](CNC(=O)C2=C[NH1][NH1]C2=N)O1 CCO[C@H1](CC(=O)N(C)CCCCN(C)C(=O)COCP(C)(C)=O)C(C)C C#CC[C@@H1](C)C(=O)N1CC[C@H1](CNC(=O)CC2=CC(F)=CC=C2F)C(F)(F)CC1 CC(C)(C)C1=NC(C(=O)NC[C@]2(C)CCN(C(=O)C=3C=C(C(F)F)[NH1]N=3)C2)=CS1 C[C@@H1](SCC1=CC=CC=C1)C(=O)N2CC[C@@H1](NC(=O)C#CC(=O)N(C)C)[C@H1](O)C2 CC1(C)CC[C@@H1](C(=O)N2C[C@H1]3C[C@H1](O)[C@@H1]2[C@@H1]3NC(=O)[C@H1]4C[C@H1](N5C=CN=N5)C4)C1 CCC1=N[NH1]C(=NCC[C@@H1]2[C@H1](C)CCCN2C(=O)C3=CC=CN4C=NN=C34)S1 CC(C)[C@H1](CCN(C)C(=O)CN1C=NC(Br)=N1)NC(=O)CC2=CC=NN2C O=C(N[C@H1]1CCC12CN(C(=O)C3=CN=C(C4=CC=CO4)S3)C2)[C@H1]5CCSC5 CCC1=CC=CC(C(=O)NC[C@H1]2CN(C(=O)CC3=CSC(C)=C3)C(C)(C)C2)=C1F CO[C@]1(C(=O)N2C[C@@H1](NC(=O)C3=COC=C3C)[C@H1]4CCC[C@H1]4C2)CCC(C)(C)C1 C[C@H1]1CC[C@H1]1CC(=O)N[C@H1]2C=CCN(C(=O)C(=O)C=3C=NN(C)C=3)C2 CO[C@@H1](F)C(=O)N1CC[C@H1](CNC(=O)C2=CC=C(C3CC3)N=C2O)C[C@H1]1C CCC=1C=CSC=1C(=O)N[C@@]23CN(C(=O)CSC4=CC=CC=N4)CC[C@@H1]2C3 COCCN(CCO)C(=O)[C@H1](CCOC)NC(=O)C[C@H1]1C[C@H1](SC)C1 CC1=NC([C@@H1]2CCCCN2[C@H1](C(=O)NC[C@@H1]3CCCO3)C4=NC=CC(Cl)=C4C)=NO1 C[C@@H1]1C[C@H1](C(=O)N[C@]2(CO)CCCN(C(=O)C3CC(C)(C)C(C)(C)C3)C2)CN1C CN(C)C1=CC=C([N+1](=O)[O-1])C=C1NC(=O)N2CCC[C@@H1]2C[C@@H1](O)C3=CC=CC=C3 COC1=CC=C2C=C(C(=O)N3CC[C@H1](C)[C@H1](NC(=O)C(C)(C)CO)C3)N=CC2=C1 C[C@@H1](C(=O)NCCNC(=O)C1=CC=C(C(N)=O)C=N1)N2CCP(C)(=O)CC2 CC(C)(CCCNC(=O)C1=CN2C=NN=C2C=N1)NC(=O)C34CC(CO3)C4 CC[C@H1](C(=O)NC1(C(=O)N2CCOC[C@@](C)(O)C2)CC(F)(F)C1)N(C)C O=C1C[C@H1](NCC=2N=COC=2Br)CN1CC3=CC=CS3 CC(C)(C)C1(C(=O)NC2[C@@H1](NC(=O)COC3CCCCC3)C[C@@H1](O)C2)CCCC1 C[C@H1]1C[C@@H1]1C(=O)NC[C@H1]2CN(C(=O)[C@H1]3CC4CCC3CC4)[C@H1]5CCN2C5 CCC[C@H1](CCCNC(=O)C1(C)CC(C)C1)NC(=O)CCN2C=C([N+1](=O)[O-1])C=N2 CCN(C(=O)[C@H1](O)C(C)(C)C)[C@@H1]1CCN(C(=O)C=2C=C(Br)N3C=2CCC3)C1 CCOC[C@H1](C)N[C@H1](C1=NN=NN1C2(C)CC2)C3(C)CC4(C3)OCCO4 CC(C)(C)/C=C/C(=O)NC(C)(C)C(=O)N[C@@H1]1CCN2CCC[C@@H1]12 CC#CC[C@H1](NC(=O)CN1CCCC[C@H1]1C)C(=O)N[C@@H1]2CCCN(C)C2=O O=C(N[C@H1]1CC12CCOCC2)[C@@H1]3C=CCCN3C(=O)[C@H1]4C[C@@H1]4C5CCC5 CC[C@@H1]1OCC[C@@H1]1C(=O)N2CCC[C@](C)(NC(=O)CCC3=CN=C(C4CC4)O3)C2 CN(CCCN(C)C(=O)[C@H1]1C[C@]12CCOC2)C(=O)[C@H1]3CCC(F)(F)[C@@H1]3O CCCC[C@@H1](C)C(=O)N1CC=C[C@@]1(COC)C(=O)N2CC3(CCOC3)C2 COC(=O)C1=NSC=C1NC(=O)[C@H1]2CN(C(=O)C3=CC(Cl)=NC(Cl)=C3)CCS2 C=CCC1(C(=O)N[C@@H1]2CCCC[C@H1]2CNC(=O)C[C@H1](C)C3=CC=NC=C3)CCC1 CC1=C(O)C=CC=C1NC(=O)[C@@]23C[C@@H1]2CN(C(=O)C4=C(Br)C=C(F)C(F)=C4F)C3 CC(C)[C@](C)(O)C(=O)N1[C@H1]2C[C@H1]1CN(C(=O)C3=CCSC3)C2 CSC1=CC=C(C(=O)N2C[C@H1]3CN(C(=O)C4=CN(C(C)C)C=N4)CC[C@H1]3C2)O1 C[C@]1(C(=O)N2CC3(CC[C@@H1]3O)C2)CCCN1C(=O)C[C@@H1]4COC[C@H1]4O CC(C)(C)SCC(=O)NCC1=CN([C@H1]2C[C@@H1](C(C)(C)C)NC2=O)N=N1 COC(=O)C[C@@H1]1CCCN1C(=O)[C@H1]2CCN(C(=O)[C@@H1](NC(C)=O)C(C)C)C2 CSCCCN=C1[NH1]C(N2CCOCC3(CC3)C2)=NC4=C1COC4 COC1=C(C)C=C(NC(=O)C2CC3(C2)CN(C(=O)C4=CN=CC(Br)=C4)C3)C=C1C CC1=CC(Cl)=CC=C1CN2CC[C@@H1](NC(=O)C3=CC=CC=4SN=CC3=4)[C@@H1](O)C2 O=C(N[C@H1]1C[C@@H1](O)CN(C(=O)C2=CN=C3C(=C2)COC3)C1)C4=CSC(Cl)=C4 C[C@@H1](NC(=O)CCC1=CC=CC=N1)C(C)(C)NC(=O)C2=CC=C(C(F)F)N=C2 C=C[C@H1](C1CC1)N(C)C(=O)[C@]2(NC(=O)CO[C@H1]3CCOC3)CC2(C)C CCC=1C=C(C(=O)N2C[C@H1]3C[C@H1]2CCN3C(=O)[C@H1](C)C4=CN=CN=C4)OC=1CC CCOCCC(=O)N[C@@H1]1C[C@H1]1[C@H1]2CCCN(C(=O)C3=CC(C)=C(C)[NH1]3)C2 CC1=CC=C(Cl)C(C(=O)N[C@@H1]2CN(C(=O)CC3CC(F)(F)C3)C[C@H1]2CC4CC4)=C1 CN(C[C@@H1]1CCCCN1C(=O)[C@@]2(C)CCCO2)C(=O)CCCOC3=CC=CN=C3 CC=1C=COC=1C(=O)N2CCC3(CC2)C[C@@H1]3NC(=O)[C@H1]4CCC[C@H1]4O O=C(C=CC1=NC=C[NH1]1)N2CCCN(C(=O)C3=CC=C4C(Cl)=NC=CC4=C3)CC2 CC1=CC(C(=O)N[C@H1]2CCCCC[C@H1]2C(=O)N3CC[C@H1](C)[C@H1]3C)=NN1C COCC1(COC)C[C@H1]1C(=O)N[C@@H1]2CCCC[C@@H1]2NC(=O)C3=CN=N[NH1]3 CC=1N=C2N(N=1)CCN(C(=O)C[C@@H1]3CC(C)(C)CN3C(=O)C(N)=O)C2 CC1=CN=C(C(=O)NC[C@@H1]2N(C(=O)[C@@H1]3CC34CCCCC4)CCCC2(C)C)C=N1 CN(C[C@@H1](O)C1CCC1)C(=O)[C@@H1](NC(=O)C2CC(C)(F)C2)C3(C)CC3 O=C(C[C@H1]1CC2=CC=C(Br)C=C2C1)N[C@@H1]3CCN(C(=O)C4=CC=CC=C4)C3 CN1N=NN=C1[C@@H1](NC2=CC=C3C(=C2)CCCC3=O)C4=CC=CC5=NSN=C45 CC1(C)[C@@H1](O)C[C@H1]1NC(=O)C=2OC=CC=2CNC(=O)C3C4CC5CC(C4)CC3C5 C=C=C[C@H1](C)C(=O)N1C[C@H1](C(=O)N2CC(CC)(CC)C2)C(F)(F)C1 CCOC1=CC(C(=O)NCCNC(=O)[C@@](O)(CN(C)C)C(F)(F)F)=CC=C1OC CC(C)CSCC(=O)N1C[C@@H1](NC(=O)C2CC3=CC=CC=C3C2)[C@@H1](C4CC4)C1 CN(C)CC1=CC=C(C(=O)NC[C@H1]2CC[C@H1]2NC(=O)C(F)(F)C3CCCC3)C=N1 C=CCC(C)(C)C(=O)OC=1C=CC(=O)N(C2=CC=C(F)C=C2F)C=1 CO[C@H1](C)C(=O)N[C@@H1]1C[C@@H1](C)CN(C(=O)C(C)(C)C)C1 CN1CCC(C(=O)NC[C@H1]2CN(C(=O)CC3=CSC(Cl)=C3)CCCO2)CC1 C[C@@H1]1[C@H1](NC(=O)CCCN2C=NC=N2)C[C@H1]3CC[C@H1]1N3C(=O)[C@H1]4CCN4C O=C(N[C@@H1]1CN(CC2=CC=C3N=C(O)[NH1]C3=C2)C[C@H1]1F)C4=CC(Cl)=C(Cl)C(Cl)=C4 CCN(CC)C(=O)[C@H1](C)NC(=O)[C@@H1]1CC12CCN(C(=O)[C@H1]3C[C@@]3(F)Cl)CC2 CC1(C)CCN(CC2=CC=C(F)C=C2Cl)C[C@@H1]1NC(=O)C=3C=NSC=3 C#CCCOCC(=O)N1CC[C@H1]2CC[C@@H1](C1)N2C(=O)CCN(CC)CC CC(C)[C@](C)(O)C(=O)N1C[C@@H1](CNC(=O)CCOCC(F)(F)F)OC2(CCC2)C1 CC1(NC(=O)C[C@H1]2[C@H1]3CCC[C@H1]3N2C(=O)CCC4=CC=CN=C4)CSC1 CNS(=O)(=O)CCC(=O)N(CCCNC(=O)[C@H1](C)[C@H1]1CCOC1)C2CC2 C[C@H1]1OCCO[C@H1]1C(=O)N[C@H1]2C[C@H1]2NC(=O)C3=C[NH1]N=C3C4CCC4 [N-1]=[N+1]=NCC(=O)N[C@]1(C(=O)NCC[C@@H1](O)C(F)(F)F)C[C@H1](O)C1 CC(=O)N1CC[C@@H1](C(=O)NC[C@@H1](O)CNC(=O)C=2C=CN(CC3CC3)C=2C)C1 CC=1N=C(Cl)SC=1[C@H1](NCCC2=NC=C(Br)C=N2)C3=NN=NN3C4CCOCC4 C#CC[C@H1]1CN(C(=O)[C@H1](CC(=C)Cl)NC(=O)[C@@H1]2CC[C@H1]2C#N)CCO1 O=C(NC1(CNC(=O)C(F)(F)C2=NC=CC=C2F)CCOCC1)[C@H1]3CC=CCO3 CC[C@H1](C)CC(=O)NC1(CCNC(=O)C(C)(C)C2=CC=C(C)C=C2)CCC1 CC1=NC(C(=O)N[C@](C)(CNC(=O)CCC2=NN=CS2)C3CCC3)=CO1 CCC(CC)C=1C=C(C(=O)NC[C@@H1](CNC(=O)C2=C(C)C=CN2C)OC)ON=1 CC1=CN=CC(C)=C1C(=O)N[C@H1]2CC[C@H1]2CNC(=O)C=3N=NN4C=CC=CC=34 C[C@H1](C(=O)NC1CC2(CC(NC(=O)C3=CC=CC4=C3NCC4)C2)C1)N(C)C CC[C@H1](C)CCC(=O)NC[C@@H1]1CN(C(=O)C2=CC=C(C)C(OC)=C2)CCN1C CCOC1=CC(Cl)=CC=C1C(=O)NC[C@H1](O)CCNC(=O)C(C)(C)CCOC CO[C@@H1](CCNC(=O)C=1OC=CC=1C)C(=O)NCCCSC(F)F C=CCC[C@@H1](C)N=C1[NH1]C(=NC)[NH1]C(=NCC2(C(C)(F)F)CCC2)[NH1]1 O=C(CN1C=C(C2CC2)C=N1)N3C[C@H1]4[C@H1](NC(=O)C5(C(F)F)CCC5)[C@H1]4C3 C[C@H1](CC1CN(C2=CC(C(F)F)=NC=N2)C1)NC(=O)[C@@H1]3C[C@H1](O)CN3C(N)=O CS(=O)(=O)N1CC[C@@H1]1C(=O)N[C@H1]2C[C@@H1](CNC(=O)CCCCC#N)C2 CCC[C@H1]1CN(C(=O)CNS(N)(=O)=O)C[C@H1]1NC(=O)CC2=CC=CC(C)=C2C CO[C@@H1]1CN([C@@H1](C)C2=NN=C(CC=3C=CSC=3)N2CC4=CC=CS4)C[C@H1]1F CC[C@@H1](CNC(=O)[C@H1]1CCO[C@@](C)(CC)C1)NC(=O)C2=CC=NC(O)=C2 CCCCCC[C@H1](F)C(=O)OCC=1C=NN(C)C=1I OC=NC=CN=CC=CC(C1=NC(C2CCCC2)=NN1CC3CCCCC3)=CC=N CCN(C[C@H1](C)NC(=O)C1(C2=CC=CC=C2)CCC1)C(=O)CC3=CCOCC3 O=C(NC[C@H1](NC1=C(Br)C=CC=C1[N+1](=O)[O-1])C2CC2)C3=NC=CN=C3Cl C#CC1(C(=O)NCCCC(=O)OC)CN(C(=O)[C@@H1](C)[C@H1](O)C(C)C)C1 CN1N=NC(CNC(=O)CC(F)(F)C(F)F)=C1C(=O)NCCC2=CSC=N2 CSCC(C)(C)C(=O)N1C[C@@H1]2C[C@H1]1[C@@H1]2NC(=O)C3CCN(C(C)C)CC3 C[C@@H1](CC(F)(F)F)C(=O)NCC1(NC(=O)CC(C)(C)C2CC2)CCCC1 CC1=NN=CC=C1C(=O)NC[C@@H1]2CC[C@@H1](C)CN2C(=O)CC(=O)NCC(F)(F)F CC1=NC=C2N1CC[C@@H1](NC(=NCCC(=O)N(C)C)NCCS(=O)(=O)C(F)F)C2 C#CCC(C)(C)C(=O)NCC1(F)CC(NC(=O)C2=CC(F)=CC(Br)=C2)C1 CO[C@@H1](C(=O)N[C@H1]1CO[C@H1]2CN(C(=O)C3=CC(C(C)(C)C)=NO3)C[C@@H1]12)C(C)(C)C COC[C@]1(C(=O)N2C[C@@H1](C)C[C@@H1](C)C2)C=CCN1C(=O)CCCCSC COC=1C=C(C(=O)NC[C@H1](NC(=O)CC=2C=C[NH1]N=2)C3=CC=CC(Cl)=C3)ON=1 CSC(SC)C(=O)NCCN1CCC(NC(=O)[C@@H1]2CC3=CC=CC=C32)CC1 CC[C@@](C)(CNC(=O)CCCC1=CC=C(Cl)C=C1)NC(=O)CC2CN(C)C2 CC1=NN(C2CC2)C(Cl)=C1C(=O)N[C@H1]3C[C@H1](F)CN(C(=O)C#C[C@@H1]4CCCO4)C3 N#CC=1N=CN(CC(=O)NCC[C@H1](O)CNC(=O)/C=C/C2=CC=C(Cl)S2O)N=1 COC1(CCNC(=O)CC2=NC=CN2C)CN(C(=O)C=3OC(C(F)F)=CC=3C)C1 CO[C@@]1(CNC(=O)CSCC(=O)C2=CC=CC=C2)CCSC1 NC(=O)C1=CC(C(=O)NCC2(NC(=O)CC3CCCC3)CCC2)=N[NH1]1 O=C1CCCN1CCC(=O)N2CCC[C@H1](NC(=O)C3(F)CCOCC3)CC2 CSCC[C@@H1](O)C(=O)NCC[C@@H1](C)NC(=O)C1=CC(C2=CC=CO2)=NO1 CC1=CN=CC(C(=O)N(C)[C@@H1](CC(C)C)C(=O)N[C@@H1](C)C(=O)OC(C)C)=N1 CC[C@]1(C)C[C@@H1]1C(=O)NCC2(NC(=O)C3=CN(CC(F)(F)F)C=N3)CC2 CN(C)[C@H1](C(=O)N[C@]12CCCC[C@@H1]1C2)C3=CC=C4C(=C3)OCCO4 CN1C=C(C(F)(F)C(=O)NC[C@@H1]2CN(C(=O)C=C3CCCCC3)CCCO2)C=N1 CSC=CC(=O)N1C[C@@H1](O)[C@H1](N(C)C(=O)C2CC3(CCCCO3)C2)C1 O=C(N[C@]12C[C@H1]1[C@@H1]3CC[C@H1](C2)N3C(=O)C4=CC=CC=5N=C[NH1]C4=5)C6=NOC=C6Cl CCN(C)CCC(=O)NCCN(C(=O)[C@H1]1CC(C)=NO1)C2CCCCCC2 CC[C@H1](SC)C(=O)N(C)C[C@@H1]1CCN(C(=O)C2=CSN=C2OC)C1 COC[C@@]1(C(=O)N2CCC[C@](C)(CO)C2)C=CCN1C(=O)CCCC3CC3 C#CC[C@@](C)(NC(=O)[C@@H1]1CCCC(=O)N1C)C(=O)NCC2=NN=C(C)O2 CCC[C@@](C)(CC)NC(=O)[C@@H1](C)NC(=O)C=C1CCC1 C=CCCCCCCC(=O)NC/C=C/C(=O)N1CCC(CC)(CO)CC1 C[C@@H1](NC(=O)C[C@@]1(C)CCN1C(=O)C2=C[NH1]N=C2[N+1](=O)[O-1])C3=CC=NC=C3F CC1=CSC(CC(=O)NC2CC(N(C)C(=O)CCNC(N)=O)C2)=C1 CCNC(=O)CCCC(=O)N(C)[C@H1](C)CNC(=O)CCC1=CC=C(F)C=C1 CCC1=NC=CC=C1C(=O)N2CC[C@H1](NC(=O)C3=CN=CC=C3C#N)[C@@H1](C)C2 CCN(C)CC(=O)N1C[C@H1](C)[C@H1](NC(=O)CN(C)C2=CC=NC=C2)C1 CC[C@@H1](CC(C)C)C(=O)NC[C@]1(O)CCN(C(=O)C=C[C@H1]2COC(C)(C)O2)C1 CO[C@@H1](F)C(=O)N(CCNC(=O)[C@@H1]1C[C@H1]1C2=CN=CN2C)C3CCCC3 CC1(CCCC(=O)NCC2(NC(=O)CC3CC4(CC4)C3)CCCC2)N=N1 CCC[C@@H1](CCCNC(=O)[C@]1(C)C[C@@H1]2C[C@@H1]2C1)NC(=O)COC3CCCCCC3 CCC=1[NH1]N=C(Cl)C=1C(=O)N[C@H1]2CCN(C(=O)C3(O)CCCCC3)C[C@H1]2C CC[C@H1](NC(C)=O)C(=O)N1C[C@H1](O)C[C@@H1]1CNC(=O)[C@]2(C)CO[C@H1](C)CO2 CC=1C=CN(CC(=O)NCCCN2CCN(C(=O)[C@@]3(Cl)CC3(C)C)CC2)C(=O)C=1 CC[C@H1](CC(=O)NC[C@@H1]1CC2(CCC2)CN1C(=O)C3=NSC=C3N)OC CC(C)OCC(=O)N(CCO)[C@@H1]1CCCN(C(=O)C2(C)CC(F)C2)C1 O=C(CC1=CC=C(Cl)S1)N[C@@H1]2[C@H1]3C[C@@H1]4CN(C(=O)CN5CCCCC5)[C@@H1]2[C@H1]4C3 CC1=NN=C(C(=O)N2CCCC[C@H1](NC(=O)C3=CN(C)N=C3C(C)(C)C)C2)S1 O=C(N[C@@H1]1CN(C(=O)C#CC2CC2)C[C@H1]1C3=CC=CC=C3)[C@H1]4COCCO4 CCCC(=O)NC[C@H1](C)C1CCN(C(=O)CCC2=CC=CC(F)=C2)CC1 CO[C@H1](CC1=CC=CC=C1)C(=O)N2CC[C@@H1](N(C)C(=O)CC(F)F)C3(CC3)C2 O=S(=O)(C1CC1)N(C[C@@H1]2CCCO2)C3CCC4(CCNCC4)CC3 C[C@H1]1CN2CCN1[C@H1](C(=O)N3CCC(O)(CCNC(=O)C4(F)CC4)CC3)C2 CC=1C=CN2C=NC(C(=O)N[C@@H1]3CS(=O)(=O)C[C@@H1]3NC(=O)COCC(C)C)=C2C=1 CC1=CN=C(C(=O)N[C@H1](CNC(=O)[C@@H1](C)CC(F)F)C2=CC=CC=C2F)C(F)=C1 CC=CC=CC(=O)N[C@@H1](CC1CC1)C(=O)N[C@@H1](C)C2CC2 COC[C@H1](C(=O)NC1(CNC(=O)[C@H1](F)CC2CCCC2)CCC1)N(C)C CC1=CC(Cl)=CC=C1C(=O)N[C@]23C[C@H1]2[C@@H1]4CC[C@H1](C3)N4C(=O)C=CC5CCCC5 O=C(N[C@H1]1C[C@@H1](O)[C@H1](NC(=O)C2=CSC(S)=N2)C1)C(F)=CC3=C[NH1]C=N3 CN(CCO)CCC1=CN(C[C@H1]2C[C@H1](O)CN2C(=O)[C@H1]3CCCC(=O)C3)N=N1 CC[C@H1](O)CC(=O)N1CCO[C@H1](CN=C2[NH1]N=C(C=3C=CON=3)S2)C1 O=C(N[C@@H1]1C[C@H1]2C[C@@H1](C1)N(C(=O)[C@@H1]3CCCO3)C2)C4=NC5=CC=CC=C5[NH1]4 COC1(CC(=O)N2C[C@@H1](O)C[C@H1]2C(=O)N[C@@H1]3CCC[C@H1]3CCO)CCC1 CN(CCCNC(=O)CCOCC(C)(C)C)C(=O)CCCCC(F)F CC(C)C[C@@H1](C)CC(=O)NC[C@](C)(CO)NC(=O)C1=CC(Cl)=NC(Cl)=C1 C[C@@H1](CC=1C=NN(C)C=1)C(=O)N[C@@H1]2CC23CC(NC(=O)C4=CN=C[NH1]4)C3 CN(C)[C@@]1(C(=O)N2CCC(N(CCO)C(=O)[C@@H1]3CCCCS3)CC2)CCCSC1 COC(=O)[C@@]1(C)C[C@@H1](N(C)C)CN1C(=O)C2=CC=C(N3CCOCC3)C(OC)=C2 CC1(C)C[C@@H1](C(=O)N2C[C@H1](O)[C@@H1](N=[N+1]=[N-1])C2)CCN1C(=O)C3=CCCSC3 CC1=NC=CC(C(=O)N2CCC[C@H1]2[C@H1](C)NC(=O)[C@@H1](C)C(=O)N3CCOCC3)=N1 O=C(NCC1=CC=NC=N1)[C@@H1]2C=CCCN2C(=O)[C@H1]3C[C@@]3(Cl)Cl CC(C)(C)CCC(=O)NCCC1(NC(=O)C(=O)NCC(F)(F)F)CCC1 CCN(CCCNC(=O)CCNC(N)=O)C(=O)C1=CSC(C2=CC=CS2)=N1 COCC1=NC(C)=C(C(=O)N2CC(O)(CCNC(=O)[C@@]3(C)CCC(=O)NC3)C2)S1 C[C@@H1](CN1CCCCC1)C(=O)OCC2=NC3=C(S2)CCCCC3 CO[C@@](C)(CO)C(=O)N[C@H1]1C[C@](C)(NC(=O)[C@H1]2CCCO[C@H1]2C)C1 CCCCC[C@@H1](O)C(=O)N[C@H1](C)[C@@H1](CO)NC(=O)CC1=CC=CN=C1 CN(C)CC=1C=COC=1C(=O)NC[C@H1](NC(=O)C(C)(C)C)C2=CC=C(F)C=C2F CC1(C#CC(=O)NCC23CC(C2)[C@@H1](NC(=O)[C@@H1]4CC5CCC4CC5)CO3)COC1 CC1=NC(NC2=CN=CC(C3=CC([N+1](=O)[O-1])=CC=C3F)=C2)=NC=C1Br CN1[NH1]C(=N)C=C1C(=O)NC[C@H1]2CC[C@H1](NC(=O)CN3CC(=O)N(C)C3=O)CC2 CC1=C[NH1]N=C1CNC(=O)C2=C(CNC(=O)C3CC4(CC(C)C4)C3)N=NN2C C#CC[C@H1](CC(F)F)C(=O)NC(C)(C)C(=O)N1C[C@@H1]2CC[C@H1](C1)OC2=O CCN(CCN(CC)C(=O)[C@H1](O)CC(C)C)C(=O)C1=CC(N)=NC(Br)=C1 O=C(CC1(CO)CC1)N[C@H1]2C[C@H1]3C[C@@H1](NC(=O)C4=CC=C5C=CN=CC5=C4)[C@@H1]2C3 CN(C)C1=CC=C(C=2N=C(C3=CC=C4C=NOC4=C3)N(CCC(C)(C)C)N=2)C=C1 CC1(C)CC2=CC=CC(NC(=O)N[C@@H1]3CC[C@H1](CS(N)(=O)=O)C3)=C2O1 CC1=CN=C(F)C=C1[C@H1](NC2(CCF)CC(O)C2)C3=NN=NN3CCCF O=C(CCN1CCC(O)CC1)N[C@H1]2CC[C@@H1](NC(=O)C=3C=CON=3)CC2 CN1CCC=2SC(C(=O)N3CCO[C@@H1](CNC(=O)CCN4CCCC4)C3)=CC=2C1 CC(C)(C)[C@H1](CNC(=O)C=1C=C(Br)N(C)N=1)NC(=O)C(C)(C)[C@@H1]2CCCO2 CC1(C(=O)N[C@@H1](CNC(=O)C[C@@H1]2OCCCC2(C)C)C3CCCC3)CSC1 O=C(NCC1[C@H1]2CN(C(=O)C3=CC(F)=N[NH1]3)C[C@H1]12)C4=CC=CC(C5CC5)=N4 CC1(CCC(=O)NC[C@@H1]2C[C@@H1]3COC[C@@H1]3N2C(=O)COCC=4N=C[NH1]N=4)CC1 CCN1C=CC(CN(C)C(=O)COC2(C)CN(C(=O)[C@H1]3CC3(C)C)C2)=N1 CC[C@@](F)(C(=O)N1C[C@H1](NC(=O)CC(C)(C)C)C2(CC2)C1)C(=O)OC CC(=O)N1CCC(NC(=O)[C@H1]2C[C@H1](NC(=O)C(C)(C)N(C)C)C2(C)C)CC1 CN(CCCNC(=O)C1=CC=C(Cl)C=C1)C(=O)C2=NN(C)C(Cl)=C2Cl CC(C)NC(=O)[C@@H1]1CCC[C@H1](N[C@H1](C)[C@H1](C)NC(=O)OC(C)(C)C)C1 CCOC1=CN=C(C(=O)N(C)C[C@H1](C)CNC(=O)C2=NC=NC(C)=C2C)C(Cl)=C1 C=CCC1(C(=O)N[C@@H1]2CCC[C@H1](NC3=CC=C(Br)C=C3[N+1](=O)[O-1])CC2)CCCC1 CNC(=O)C[C@@H1](C)CNC1=CC(N2CCO[C@](C)(C(F)(F)F)C2)=NC(C(C)C)=N1 CNS(=O)(=O)CC(=O)N(C)C[C@@H1]1CN(C(=O)C2=CC=CC3=CN=CN23)CC14CC4 CN1C=C(C=CC(=O)N2CCC[C@@H1](C3CN(C(=O)CCC=4C=CSC=4)C3)C2)N=N1 C[C@H1](CN1C=CC=N1)C(=O)N2CCN(C(=O)CC3C[C@H1]4C[C@@H1]4C3)[C@@H1](CO)C2 O=C(C(=O)N1CC[C@@H1](C2=CC=CC=C2O)C1)N3CCC([C@@H1](F)C(=O)O)CC3 CC1=NON=C1CNC(=O)[C@H1](NC(=O)[C@H1]2CCC[C@@H1]2O)C3=CC=NN3C CCC1(C(=O)OC)CCN(C(=O)[C@@]2([C@H1]3CCCO3)CCCO2)CC1 C[C@H1](CCN(C)C(=O)CCC1CCCCC1)NC(=O)CC2=CSN=N2 C=CC1=CC=C(C(=O)N2C[C@@H1](C)CN(C(=O)C=3[NH1]C(C)=CC=3C)[C@H1](C)C2)C=C1 CC(C)CC(C)(C)C(=O)N1[C@H1]2CC[C@@H1]1C[C@@H1](N(C)C(=O)CN3CCC(C)(C)C3)C2 CC(C)N1N=CN=C1CNC(=O)C2(NC(=O)COC(C)(C)C)CCOCC2 COCC1=CC(C(=O)NCC2=CC=C(C(=O)N[C@H1](C)CC(N)=O)C=C2)=NO1 CC(C)CC[C@H1](NC(=O)C1=CC=CN=N1)C(=O)N[C@H1]2CC(=O)N(O)C2 CC1=CC(C(=O)N2C[C@@H1](O)[C@H1](NC(=O)CNC(N)=O)C2)=NC=C1Cl COC1=CC=C(C[C@@H1](C)CNC[C@H1]2CCC=3N=NN(C)C=3C2)C=C1F CCC1=CN([C@H1](C)C(=O)N2CC3(CCC[C@H1]3NC(=O)C=CSC4=CC=CC=C4)C2)N1 CC(C)(C)[C@@H1](O)C(=O)N[C@H1]1CCOC[C@H1]1NC(=O)C=2SC=CC=2F C[C@@H1]1[C@H1](C(=O)NC[C@@](C)(O)CNC(=O)C2=NN(C)C=C2S(N)(=O)=O)[C@@H1]1C C[C@@H1](CCNC(=O)[C@H1]1SCCN1C(=O)OC(C)(C)C)O[Si](C)(C)C(C)(C)C COC[C@@]1(CNC(=O)C2=CC(S(C)(=O)=O)=CO2)CCCN1C(=O)[C@@H1]3C[C@H1](O)CN3 CC1(C)C[C@H1](C(=O)NCCCCNC(=O)[C@@H1]2CCCN2C=O)C(C)(C)O1 CC1=CC(OCC(=O)N2CCN(C(=O)CC[C@@H1]3CCC(=O)C3)C[C@@H1]2C)=NO1 O=C(NCC1=CCCN(C(=O)C(F)(F)C2(O)CCCC2)C1)C3=NC=CC=N3 COC(=O)N1CC[C@@H1](NCCCCS(N)(=O)=O)C1 CCCN(C(=O)C=1C=CSC=1)[C@@H1]2CCN(C(=O)C3=C(Cl)C=CC(C)=C3O)C2 CSC[C@@H1](C)C(=O)N1CC[C@](CF)(NC(=O)C2=CC(CC3=CC=CC=C3)=C[NH1]2)C1 CC[C@H1](CCCC(=O)N1CC(N2C=CN=N2)C1)NC(=O)C[C@@H1]3CCO[C@@H1]3C CC(C)CO[C@@H1](C)C(=O)N1CC(C2CCN(C(=O)C3=CC=CC(N)=C3O)CC2)C1 CC(=O)OCCCC(=O)N1CCC[C@@H1]1C(C)(C)C(=O)N2C[C@H1]3CCC[C@@H1](C3)C2 CC1=CC(C)=CC(C(=O)N2C[C@H1](F)[C@@H1](C(=O)N[C@H1]3CCC=CCCC3)C2)=C1 CC1(CC(=O)N[C@@]23CC[C@@](CNC(=O)[C@@H1]4CCC5=C(Cl)C=CC=C54)(C2)OC3)CC1 CCOC(=O)C1=CC=CC=C1NC(=O)[C@H1]2CCCN2CC3=C(Cl)C=CC(Br)=C3F CN1CCC[C@@H1](CNC(=O)C(C)(C)CCCNC(=O)C[C@H1]2C[C@@H1]2C3CC3)C1=O COC[C@H1](C)C(=O)N1CCC[C@@H1]([C@H1]2CCN(C(=O)C(F)(F)CO)C2)C1 COC=1C=C(C(=O)N[C@H1]2C[C@@](F)(CNC(=O)C3CC(CCO)C3)C2)ON=1 CC=1C=CN(CCC(=O)NCC[C@@H1]2CN(C(=O)[C@H1]3CC4=CC=CC=C43)CCO2)N=1 CC[C@@H1](CN(C)C(=O)C1(C)CCC(C)CC1)NC(=O)C2=CC3=C(C)C=CC=C3O2 C[C@@H1]1CN(C(=O)C(C)(C)CC#N)C[C@H1]1CNC(=O)C(F)=CC2=CC=CN=C2 COC1=CC=C(O)C(C(=O)N2CCCC23CCN(C(=O)[C@H1](C)[C@H1](C)O)CC3)=C1 CCN(CC)CC(=O)N[C@H1]1CC[C@@H1](O)CN(C(=O)[C@H1]2CCCN2C(=O)C3CC3)C1 CC(=O)C1=CC=CC(S(=O)(=O)N2CC(C(=O)NC3=CC=C(Br)N=C3C)C2)=C1 C=CCN1C=C(C(=O)N[C@@]23C[C@@H1]2CN(C(=O)C4=CN=CC=5N=C(O)[NH1]C4=5)C3)N=N1 COC1=CC=CC=C1COC[C@H1](O)CN(C)[C@@H1](C)CNC(=O)C2=CC=CC=C2O O=C(CCC1=CC=C2C(=C1)OCCO2)NC3=CC=C(SC4=CN=CC=N4)C(Cl)=C3 CC1=CC=C(CC(=O)N[C@H1](C)CNC(=O)C2=CC=CC=C2)C=C1 CS(=O)(=O)C1=CC(S(=O)(=O)NC2=CC=CN3C(Br)=CN=C23)=C(Cl)S1 O=C1NC2=CC=CC=C2[C@H1]1N[C@@H1](C3=CC=C(O)C(F)=C3)C4=NN=NN4C5COC5 O=C(NC1(CC(=O)N2CCC(N3CCC3)CC2)CCC1)[C@H1]4C[C@]4(F)Cl CC1=CC=C([C@H1](NC(=O)N(CC2=CC=CO2)CC3CCCCC3)C(C)C)C=C1 CC(=O)NC1=CC=C(C(=O)N2C[C@H1](CNC(=O)[C@@H1]3CCC[C@H1]3C)C[C@@H1](C)C2)C=C1 CCO[C@H1](C)C(=O)N1CC2(CC(NC(=O)[C@H1]3C[C@@H1](NC(=O)OC(C)(C)C)C3)C2)C1 CCCC[C@@](C)(F)C(=O)N(C)C[C@H1]1[C@@H1]2CN(C(=O)C3=CC=CC(C)=C3Cl)C[C@H1]12 C[C@@H1]1OC2(CO)CC1(C(=O)N3C[C@@H1]4CN(C(=O)C5(F)CC5)C[C@@H1]4C3)C2 CC1=NC=NC(C)=C1CC(=O)NC(C)(C)[C@@H1]2CCN(C(=O)C3=NC=C(F)C=N3)C2 CC1=CC=C(S(=O)(=O)NCCSC2CC2)C=C1C(=O)N3CCCC[C@H1]3C N#CC1=CC=C(C[C@H1](C#N)C(=O)OCC2(O)CN(C(=O)OC(Cl)(Cl)Cl)C2)C=C1 C#CCOCC(=O)N(CC)[C@@H1]1CCCN(C(=O)C2=CC=C(C3=CC=CS3)C=N2)C1 C[C@@H1]1C[C@@H1]1C(=O)NCCC(=O)NCCC2(NC(=O)C3CCC3)CCCC2 CN(CCN1CCOC1=O)C(=O)[C@H1]2CCCC[C@H1]2NC(=O)C[C@H1]3CCCSC3 CC(C)C1=CC=C(C(=O)NCC2(O)CN(C(=O)[C@@H1]3CCCOC3)C2)O1 CC[C@@H1]1CCC[C@@H1]1C(=O)NC2CCC(C(=O)N(C)[C@H1]3C[C@@H1](O)C3(C)C)CC2 CN1CCC[C@@]1(C)C(=O)N2CCC[C@@]3(CCN(C(=O)C4=CN=CC(F)=C4)C3)C2 C=C=C[C@@H1](C)C(=O)N1C[C@@H1](COC)C[C@H1]1CNC(=O)C2=COC(C3CC3)=N2 CC1=CN(C)C=C1C(=O)N[C@H1]2C[C@@H1](NC(=O)[C@@H1](CC(C)C)C(N)=O)C2 CC1=NN(CC(=O)N2CCC(C(=O)NC[C@@H1](O)[C@H1](C)O)=C(F)C2)C(=O)O1 C[C@H1]1C(C(=O)N[C@H1](CC2CCOCC2)C(=O)NCC3=CN=CN=C3)=NO[C@@H1]1C C=CC[C@H1](CC(C)C)C(=O)N[C@H1](C/C=C/C)C(=O)N(CCC)OC CSC[C@@H1](O)C(=O)N1CCCC[C@@H1](NC(=O)C2=CC=CC(C3(O)COC3)=C2)C1 CC1=NC(C(=O)N2C[C@@H1]3COCC[C@]3(NC(=O)CC=4C=CON=4)C2)=C(C)O1 C[C@@H1](NS(C)(=O)=O)C(=O)N1CC2(CC2)C[C@@H1]1CNC(=O)C3=CC(N(C)C)=CC=N3 CC=1C=C(CC(=O)N2C[C@H1](NC(=O)[C@@]3(O)C[C@H1]4CC[C@H1]3C4)CC25CCC5)N(C)N=1 COC1=CC(N2C=CN=C2)=CC=C1N[C@@H1](C3=CC=CC=C3C)C4CCC4 [N-1]=[N+1]=NCCCCCCC(=O)N[C@H1]1C[C@@H1]2CN(C(=O)CN3C=CC=N3)C[C@@H1]2C1 COC(=O)C1=CSC(CC(=O)NCC(C)(C)CNC(=O)C2=N[NH1]C=C2F)=C1 O=C(C=CC1=CN=CC(F)=C1)N[C@@H1]2CC[C@@H1](CCN=C3[NH1]C=NC(Cl)=C3Br)C2 CC1(C)C(C)(C)C1(C)C(=O)NCCCN=C2[NH1]C=CC(C(N)=O)=C2[N+1](=O)[O-1] CS(=O)(=O)C1=CC=C(C(=O)N[C@@H1](CO)CNC(=O)[C@H1]2CCCO2)C(Cl)=C1 CS(=O)(=O)CCC(=O)NCC1=C[NH1]N=C1[C@@H1]2CCN(C(=O)C(F)=C3CCCC3)C2 C#CCC(CC#C)C(=O)N[C@H1]1C[C@@H1](CO)N(C(=O)[C@@H1]2[C@@H1]3CCC(F)(F)[C@@H1]32)C1 CC1=NC=C(S(N)(=O)=O)C=C1C(=O)N[C@@H1](C)[C@@H1](CO)NC(=O)C2=NOCC2 O=C(CCC(=O)C1CC1)N[C@H1]2CS(=O)(=O)C[C@H1]2NC(=O)C3=CC=C(C4CC4)C=C3 CS(=O)(=O)NCCCC(=O)NC[C@@H1](CNC(=O)CC1=CCCCC1)C(F)(F)F CC(C)(C)C=1N=NN(CC(=O)N2CCOC[C@@H1]2CCNC(=O)C3CC(F)(F)C3)N=1 CC1=NC(C=CC(=O)N[C@@H1](C)C[C@H1](C)NC2=NN=CC=C2C#N)=CS1 CCO[C@@H1](C)C(=O)N1CC(NC2=CC(F)=NC=N2)C1 CO[C@H1](F)C(=O)N(C)C[C@H1](O)CN(C)C(=O)C(F)=CC1=C[NH1]C=N1 C=CCC(F)(F)C(=O)N1CCC[C@@](CC)(NC(=O)C2=CC(C)=CC(O)=C2)C1 CC[C@@H1](C)[C@@H1](C)CN1C=C(CN2CCCCC23CCCCC3)N=N1 CCCN(CCNC(=O)C1=CN2C=C(C)SC2=N1)C(=O)C3(C)CCCCCCC3 C[C@@H1]1CCCC[C@@H1]1CC(=O)N2CC3COC(CNC(=O)[C@H1](C)[C@@H1]4CCCO4)(C3)C2 CN(C(=O)[C@@H1]1CC[C@@H1]2CCCC[C@H1]2C1)C3[C@H1]4CC[C@H1]3CN(C(=O)C5(C)COC5)C4 CCCCCC(=O)N[C@H1]1CCN(C(=O)[C@H1]2C(C)(C)C2(F)F)[C@@H1](C)C1 O[C@@H1](CC1CC1)CN=C(NC2CCCCC2)N3CC[C@H1](N4C=CC=N4)C3 CON1CCC(CC(=O)N2CCO[C@H1](C3=CN(CC4=CC=C(Br)S4)N=N3)C2)CC1 [N-1]=[N+1]=NC[C@@H1]1CCN1C(=O)C23[C@@H1](NC(=O)[C@@H1]4C[C@H1]5C[C@@H1]4C[C@H1]5O)C6C[C@H1]2[C@H1]3C6 CO[C@@H1](C1=CC=C(Cl)C=C1)[C@@H1](C)NC(=O)C(=O)NC2=CC(N3C=CC=N3)=CC=N2 O=C(NCC(F)F)[C@@H1](C1=CC(Cl)=CC=C1Br)N2CCN(CCCF)CC2 CCCCCCN1N=NN=C1[C@H1](N[C@H1]2CCN(S(C)(=O)=O)C2)C3=CC=NC(C)=C3 C[C@H1](NC(=O)C1CCCC1)C(=O)N[C@H1](C)CN(C)C2=NC3=CC=CC=C3C=C2Br CC1=NOC(C)=C1C[C@H1](C)C(=O)N[C@H1](C)C2CCN(C(=O)C[C@@H1]3CCOC3)CC2 CN(C(=O)C1=CC(O)=NC(C2CC2)=N1)[C@@H1]3CCN(C(=O)[C@H1](O)C(F)(F)F)C3 COCC1=CC=CN=C1C(=O)N[C@@H1]2CS(=O)(=O)C[C@H1]2NC(=O)C3=NNC(=O)C3 CSC1=CC=C(CN(C)C2=NC(N[C@H1]3CC[C@H1]4CC[C@@H1]34)=C5C=CC=C(F)C5=N2)O1 C#CCCC(=O)NC[C@H1](C)CN(C)C(=O)C=1OC2=C(OC)C=C(C)C=C2C=1C CN1C[C@H1](CNC(=O)[C@@H1]2CCC[C@@H1](NC(=O)C(C)(C)CCCF)C2)CC1=O CCCCS(=O)(=O)N[C@@H1](C)C(=O)NCCCN(C)C(=O)C1=CC=CC=C1[N+1](=O)[O-1] CCN(C(=O)CCNC(=O)N1CCOC[C@H1]1C2=CC=C(Br)C=C2)[C@H1]3CCS(=O)(=O)C3 CC1=CC=CC(N)=C1C(=O)NC[C@H1](CO)NC(=O)[C@@H1](F)CC2CCC2 CCC1CC(CC(=O)N(C)CC2(CNC(=O)C3=CC4=C(Cl)C=CC=C4S3)CC2)C1 C#CCCCOCC(=O)NCCCOCC(C)(C)NC(=O)[C@H1]1C[C@@](C)(O)C1 CC=1SC=C(C(=O)N2C[C@H1](NC(=O)COC[C@@H1]3CCOC3)C[C@H1]2C)C=1N C[C@H1](NS(C)(=O)=O)C(=O)N1CC[C@@H1]([C@H1](C)NC(=O)C2=NC=C(Cl)N=C2Cl)C1 C[C@@H1](C(=O)NCCC=1OC=NC=1CNC(=O)[C@@]23CC[C@@H1](C[C@H1]2F)C3)S(C)(=O)=O C=C[C@@H1]1OCC[C@H1]1C(=O)N2CCC3(CC2)C[C@H1](NC(=O)CCOC4COC4)CO3 CC[C@@H1](CNC(=O)C1=C(CNC(=O)[C@@H1](C)N2CC(C)C2)N=NN1C)C(C)(F)F O=C(CC1(N2C=NC=N2)CC1)NC[C@]34C[C@@H1]3CN(C(=O)CC5=CC=NC(O)=C5)C4 CCNC(=O)[C@H1](C1=CN=C2SC=CN12)NCC[C@@H1]3C[C@H1]4CC[C@H1]3C4 COC1=CC(C(=O)N[C@H1]2COC[C@H1]2NC(=O)C#C[C@H1]3CCOC3)=CC=C1C C[C@@H1](F)CC(=O)N[C@H1]1C[C@@H1](O)[C@H1](NC(=O)CC2=C(Br)C=NN2C)C1 CCOCCCC(=O)N1CCC[C@@H1]1[C@@H1](C)NC(=O)CC2=CSC(S)=N2 CCC1=CC=C(C(=O)N[C@@H1](C)/C=C/C(=O)NC[C@@H1]2CC3(CC3)CO2)[NH1]1 C#C[C@]1(O)C[C@@H1](C(=O)N[C@](C)(CNC(=O)CC(=O)NCC2CC2)CN(C)C)C1 O=C(C=CC1CC1)N[C@@H1]2CO[C@@]3(CCN(C(=O)C4=CC=C(Cl)C=C4F)C3)C2 CN(C(=O)C1=CC=CC(C2CC2)=N1)C3CN(C(=O)[C@H1]4COC5=CC=CC=C5O4)C3 CC=1C=CC(=N)[NH1]C=1C(=O)N(C)[C@H1](C)CNC(=O)C2=NNC(=O)CC2 O=C(N[C@@H1]1CC12CCN(C(=O)C3=CSC(O)=N3)CC2)C4=C(F)C=CN=C4F COC(=O)C1=CSC(C(=O)NC[C@@H1]2C[C@@H1]2NC(=O)C3=CC=C(F)C(C(F)F)=N3)=C1 CCC[C@H1](O)CC(=O)N1CCC[C@H1]1CNC(=O)CC2=CC(C)=CC(F)=C2 C#CCN(CC=C)C(=O)[C@]1(NC(=O)[C@H1](C)CC2CC2)C[C@@H1](O)C1 C=CCSCC(=O)NC1(CCO)CN(C(=O)[C@H1](C)[C@@H1]2OCCC=3SC=CC=32)C1 CCN(CCCNC(=O)CC[C@H1]1CC1(Cl)Cl)C(=O)C2CCC(C)(C)CC2 C[C@@]1(CC(=O)NCCN(C(=O)CNC(=O)C2CCOCC2)C3CC3)C[C@H1]1F C[C@H1](C(=O)N1CC[C@]2(CCCN2C(=O)C3=CC=CC(Cl)=N3)C1)C4=CC=CO4 CCCCC[C@@H1](F)C(=O)N1CCC[C@@H1]1/C=C/C(=O)NCC2=CC(C)=CO2 CCC1=CC=C(C(=O)N(C)CCCCC(=O)N[C@H1](C)CN2CCOCC2)C=N1 C[C@H1](NC(=O)C(C)(C)C)C(=O)N(C)[C@@H1]1CCCN(C(=O)C2=CN(CCO)N=N2)C1 CC(=O)CCCC(=O)NC[C@H1]1CN(C)CCN1C(=O)C2=CC=C(Cl)C(Cl)=C2 CC[C@@H1](OC)C(=O)NC[C@@H1]1CN(C)CCN1C(=O)CC2(NC(C)=O)CC2 N#CC1=C(Cl)C=CC=C1OC2=CC=C(C3=NC4=CC=CC(Cl)=C4S3)C(F)=C2 CC[C@@H1](O)C(F)(F)C(=O)N1C[C@@H1](O)[C@H1](NC(=O)C2=CN3C(=N2)CCCC3)C1 C#CC1=CC=C(C(=O)N(C)[C@H1](CNC(=O)CS(C)(=O)=O)C2CC2)C(C)=C1 COCC(COC)C(=O)N[C@@H1]1CC[C@H1](CNC(=O)[C@@]2(C#N)CC3CCC2CC3)C1 CC/C=C/C[C@@H1](C)C(=O)N1C[C@@H1](NC(=O)CCC2=CC=CC=C2OC)C3(CC3)C1 C#C[C@@H1](NC(=O)C1=CC[C@H1]2CC[C@H1]1N2C(=O)CC3OCCO3)C4=CC=CC=C4 CSC1=NC=C(C(=O)N2C[C@H1]3CCC[C@@](NC(=O)CC=4C=NSC=4)(C3)C2)C(O)=N1 CSCC[C@H1](NC(=O)CC[C@H1]1CCCO1)C(=O)NC2=CC=C3C=CN=CC3=C2 COC(C)(C)CC(=O)N(C)CCOCCC(=O)NC12CC(C1)C2 COC1=CC=CC=C1C=CC(=O)O[C@@H1](C)C(=O)NC2=CC=CC=C2O CC[C@H1](C(=O)OC)C(=O)N1CCC2(CC1)OCC[C@@H1]2NC(=O)C[C@H1]3COCCO3 O=C1NC[C@@H1](CC(=O)N2C[C@H1]3C=C[C@H1]2[C@@H1](C(=O)NC4=CC(O)=CC=C4F)C3)O1 C[C@@H1](NC=O)C(=O)NCCOCCCNC(=O)C1=CC(N)=CN=C1Cl O=C(N[C@@H1]1CN(C(=O)C=CSCC2=CC=CO2)C[C@@H1]1F)C3=CCC4(COC4)OC3 O=C1N[C@@H1](C(=O)NCC=2C=NN3C=2CN(C[C@H1]4CCCOC4)CC3)CCO1 CO[C@H1](C)CC(=O)N1CC[C@@H1]2CN(C(=O)C(C)(C)C3=CCSCC3)C[C@@H1]2C1 CCN1C=C(C(=O)N2[C@H1]3CC[C@@H1]2C[C@@H1]3NC(=O)C4=NOC5=NC=CC=C45)C(C)=N1 C[C@@H1](C(=O)N1CCN(C(=O)CC2=CC=CN=C2)[C@H1](C3=CC=CN=C3)C1)C4CC4 COC(=O)[C@@H1]1CN(C(=O)C(=O)NCC2=NN=C(CCO)S2)C[C@H1]1C(=O)OC COC1(CC(=O)N2C[C@@H1](NC(=O)[C@H1](F)CC3CCCC3)CC24CCCC4)CCC1 C#C[C@H1]1CN(C(=O)[C@@H1](CC2CCC2)NC(=O)CC(C)(C)C(C)=O)CCO1 CC(C)OC[C@@H1](C)NC(=O)[C@@H1](C)N1C=C2C(=N1)CCCC2=O O=C(CCC(F)(F)C(F)(F)F)NCCC1CC(NC(=O)[C@H1](O)C2=CC=CC=C2)C1 O=C(C#CC1CCCCC1)N[C@H1]2CCC[C@@H1]2NC(=O)C3=C[NH1]C4=CC=CC(Cl)=C34 CC=1SC=C(C(=O)N[C@@H1](C)CNC(=O)[C@H1]2CC[C@@H1](C(N)=O)C2)C=1C CC(C)C1=CC(C(=O)N[C@@H1]2CCC[C@@H1]2NC(=O)C3=C[NH1]N=C3C4CC4)=N[NH1]1 C[C@H1](C(=O)N1CCN(C(=O)CCN2CCN(C)CC2)CC1)N3C=CC=N3 N#CCSCC(=O)N1CCCC[C@H1]1CNC(=O)CN2C=CN=N2 C=C1CC(C(=O)N2CC[C@](CC)(N(C)C)C2)C1 CC(C)S[C@H1](C)C(=O)N1[C@H1]2CC[C@H1]1CN(C(=O)[C@H1]3CC[C@@](C)(O)CC3)C2 CC1(C#CC(=O)NC23CCC(NC(=O)[C@H1]4CCCC5(CCC5)C4)(CC2)C3)CCC1 COC1=CC=CC=C1SCNC(=O)[C@H1](C2=NN=C(C)S2)N3CCN4C(=O)OC[C@H1]4C3 CC1(C)CC(C)(CNC(=O)NOCCNC(=O)OC(C)(C)C)C1 CCN1C=C(C(=O)C(=O)N2[C@H1](C)[C@H1]3C[C@@H1]2[C@H1]3NC(=O)C=4C(CC)=NOC=4)C=N1 CSCCC(=O)NC[C@@]1(F)CC[C@@H1](NC(=O)C2=CC[C@@H1](C(F)(F)F)OC2)C1 O=C(NCCC1=CC=CC(F)=C1)[C@@H1](C2CC2)N3CC[C@@H1](S(=O)(=O)N4CCCC4)C3 CO[C@@H1]1CN(C(=O)C[C@H1]2CSCCO2)[C@](C)(CNC(=O)C3=NNC(=O)CC3)C1 O=CC1CO[C@@H1](C(=O)N2C[C@@H1](CNC(=O)C=3C=C(CC4CC4)ON=3)C5(CCC5)C2)C1 CCS(=O)(=O)NCC(=O)N1CCC[C@@]1(C)CNC(=O)CCN2CCC2 CCC[C@H1](C#N)C(=O)N[C@H1]1C[C@@](F)(CNC(=O)C2=NN=CC3=C2CCCC3)C1 O=C(C1=CC=C(F)C=C1Cl)N2CC[C@@H1]3CN(C(=O)C(F)(F)C4CC4)C[C@@H1]3CC2 CC1=CC=C([N+1](=O)[O-1])C=C1C(=O)N2CCC(C)(C)[C@H1](NC(=O)[C@H1](F)C3CCC3)C2 CCN(C(=O)[C@@H1]1CSCC(=O)N1)[C@@H1]2CCN(C(=O)[C@@H1](C)OC)C2 CCC1=CC=CC(NC(=O)[C@@H1](C(C)C)[C@H1](C)NC(=O)C2=CN=NC=C2C)=C1F CC[C@@H1](C)CC(=O)NC=1C=CSC=1C(=O)NC2=CC(O)=NC(OC)=N2 O=C(O)C1=CC(C2=CC=C(F)C=N2)=CC=C1OC(F)(F)F CCOC(=O)CN(C)C(=O)[C@H1](O)CNC(=O)C=1C=C2C=CC=CN2C=1 CO[C@@H1](C(=O)N1CC[C@]2(CCN(C(=O)[C@H1]3C[C@H1](O)CN3C(C)=O)C2)C1)C(C)C CCOC(=O)[C@H1]1C[C@@](F)(C(=O)N2CCN(C(=O)C=C3CCC3)[C@H1](CCOC)C2)C1 CCNC(=O)[C@H1](C=1C=NN(C2CC2)C=1)N(C)CCC3CCOCC3 CCN1CCN(C(=O)C=2C=CN(CCNC(=O)[C@H1]3CCC(=O)N3C)C=2)CC1=O C#CCCCCCCCC(=O)N(C)C[C@H1](C)NC(=O)[C@@H1]([C@@H1](C)O)N(C)C CS(=O)(=O)C1=CC=CC=C1C2=CC=C([C@@H1](NC(=O)CO)C3CC3)C(F)=C2 CC=1C=NN([C@H1](C)C(=O)NCC2(F)CC(NC(=O)CCP(C)(C)=O)C2)C=1 CCCN1C=C(C(=O)N(C)CCCCN(C)C(=O)[C@H1]2CCC[C@@H1](C3CC3)O2)N=N1 CCCCCC(=O)N(C)C1CCC(NC(=O)[C@@H1](O)CN2CCOCC2)CC1 C=C[C@@](C)(CC)C(=O)N[C@H1](CNC(=O)CC1=C(Cl)C=CC=C1Cl)C(C)(C)C CC1=CC(C(=O)N2CC[C@@](C)(CNC(=O)[C@@H1]3CC[C@H1]4CC[C@H1]3O4)C2)=C(C)O1 CC(C)OCCCC(=O)N1CC[C@H1](CNC(=O)CC(C)(C)C)C12CC2 CC1=CC(C(=O)N2CC[C@H1]3CN(C(=O)CC4(O)CCC4)C[C@H1]32)=NC=5[NH1]N=C(O)C1=5 C=C=CCCNC(=O)CC(C)(C)N(C)C(=O)[C@@H1]1CCN1C(C)(C)C CCC[C@@H1](NC)C(=O)NC12CCC(C(=O)NC3=CN=C(F)C(Br)=C3)(CC1)CC2 C=C[C@H1](O)C(=O)N[C@@H1]1CCN(C(=O)[C@H1]2CCN(C3=CC=NC=C3)C2)C[C@@H1]1F C[C@@](O)(CNC(=O)C1(CNC(=O)[C@@H1]2[C@H1]3CCCCC[C@H1]32)CC1)C(F)(F)F CC(C)C1(O)CN(C(=O)[C@@H1](CNC(=O)[C@H1]2CCC2(F)F)CC3CC3)C1 C=CCC(C)(C)CC(=O)NCCC1=CCN(C(=O)C2=CSC(CC(C)C)=N2)CC1 CC(C)(C)SCC(=O)N1CCN(C(=O)C2(F)[C@H1]3CCC[C@@H1]32)C4(CC4)C1 C[C@H1](CS(C)(=O)=O)C(=O)N1CCC[C@@](C)(NC(=O)C2=NC(Cl)=CS2)C1 CCN(C[C@H1]1CCCCN1C(=O)[C@H1](C)CC(F)(F)F)C(=O)CC2=NN=C(O)S2 COC(=O)CCC(=O)NCC1=CC(O)=NC(CNC(=O)C2(C(=O)N(C)C)CC2)=N1 CC1=CC(NC(=O)CN2C[C@@H1]3C[C@H1]3C2)=CC=C1NC(=O)[C@H1](C)CC4CCC4 C#CC[C@H1](C(=O)NC1(CNC(=O)C(C)(C)[C@@H1]2CCCO2)CCC1)C3CC3 CC1=CC=NC([C@H1](C)NC(=O)C=2C=C(CNC(=O)CCC3=CN=CO3)[NH1]N=2)=N1 CN(C)C[C@@H1](NC(=O)C1=N[NH1]C=C1Cl)C(=O)NCC[C@H1]2CCCN(C)C2 CN(CC1=CN=C2C=CC(Cl)=CN12)C[C@@H1]3CCN(C(=O)C4=CC=CC(F)=C4Cl)C3 C[C@H1](C(=O)NC[C@]1(F)C[C@H1](NC(=O)C2=CC(O)=CC(C(F)(F)F)=C2)C1)C(F)(F)F CC(C)[C@@H1](O)C(=O)N(C)C1CN(C(=O)C=C2CCCCC2)C1 C[C@@H1]1CN(C(=O)[C@@H1]2CCC3=CC=CC(F)=C32)C[C@H1]1CCNC(=O)C(=O)N(C)C CCC1=NC(C(=O)NC[C@H1](C2CC2)N(C)C(=O)/C=C/C(C)(C)C)=C(N)S1 CC/C=C/C[C@H1](C)C(=O)N1CCCC[C@H1]1CNC(=O)C[C@@H1]2COC(=O)C2 C[C@@H1]1COCCN1C(=O)C2=CSC(NS(=O)(=O)CC3=CC=C(Cl)C(Cl)=C3)=N2 CC[C@@H1](CN(C)C(=O)[C@@H1](C)NS(=O)(=O)C=1C=NN(C)C=1)NC(=O)CCCC(C)=O COC1=CC=C(NC(C)=O)C=C1S(=O)(=O)N2CC[C@@]3(CCSC3)C2 C[C@@H1](C(=O)NCC1(NC(=O)C2=CC=C(S(F)(F)(F)(F)F)C=C2)CC1)N3C=CC=N3 C[C@@H1](C(=O)O)N1C=C([C@]2(O)CCCN(C(=O)CCCCC(F)(F)F)CC2)N=N1 CCO[C@@H1](CC)C(=O)NC[C@@H1](NC(=O)CC1=C(O)N=CN=C1O)C2=CC=CC=C2 C[C@H1](C(=O)NC[C@@H1]1CN(C(=O)CC2=CC=C([N+1](=O)[O-1])C=C2F)C(C)(C)C1)N(C)C CN(C[C@@H1](O)C1=CC=CN=C1)C(=O)C2=C[C@@]3(CCOC3)C2 C[C@H1](CO)C(=O)NC[C@@]1(C(=O)NCCC2=CC=NC(O)=C2)CCCO1 CCC[C@H1]1C[C@H1](C(=O)N2CCC23CN(C(=O)C4=NOC5(CCC5)C4)C3)CCO1 C[C@H1](CN1C=C(CCNC(=O)C(C)(C)O)N=N1)NC(=O)C2=CC3=CN=CC=C3O2 O=C(CC[S@](=O)C1=CC=C([N+1](=O)[O-1])C=C1)NC2CC2 C[C@@H1](OC1CCCC1)C(=O)NC(C)(C)CCNC(=O)C23COC(CF)(C2)C3 CC=1N=C(C2CC2)[NH1]C=1C(=O)NC[C@@H1]3CCCN3C(=O)C=4C=COC=4Cl CN1C=C(C(=O)NCC[C@@H1]2CCCN(C(=O)C=3SC(CO)=NC=3C)C2)C=N1 CN1C(=O)CSC1=CC(=O)N2CC[C@@]3(CCCN(C(=O)C4=COC(CO)=C4)C3)C2 CCN1CCC(CNC(=O)CC2=CCN(C(=O)[C@@H1]3CCC[C@H1]3C)CC2)CC1 CO[C@@H1](C(=O)N(C)C1CCN(CC(=O)N[C@@H1]2CCC[C@H1](O)C2)CC1)[C@H1]3CCOC3 CC1=C[C@H1]1C(=O)N2CCCC[C@@H1]2CCNC(=O)C3=CC(O)=NC(O)=N3 C=CC[C@H1](CNC(=O)CCCOC(C)(C)C)C(=O)NC1=CN=C(OC)N=C1 CCN1N=C(C)C=C1S(=O)(=O)N(C[C@H1](C)O)CC(C)(C)C CC[C@H1]1CN(C(=O)C2=CN=C3C(=C2)CCOC3)CCN1C(=O)[C@@H1]4C[C@H1]4CCOC CC1=COC(C)=C1C(=O)NC2CC3(CCN(C(=O)[C@@]45CC=CCN4CCC5)C3)C2 C[C@H1](CCCNC(=O)C1=CC=CC(N)=C1O)NC(=O)[C@@H1]2C[C@]2(C)C3=CC=CC=C3 CCCC1=NC(C(=O)N[C@@H1]2CCCCN(C(=O)[C@@H1](C)CC(F)(F)F)CC2)=CS1 O=C(COC(=O)[C@H1]1CC12CCS(=O)(=O)CC2)NC3=CC=CC(Br)=C3 CC1=CN=C2C=CC=C(C(=O)N[C@H1]3COC[C@H1]3NC(=O)C45CCC(CC4)CO5)N12 CC[C@@H1](CCC(=O)N1CC[C@H1]2CN(C(=O)C3=C(C)SC(C)=C3C#N)CC[C@H1]2C1)OC CCC[C@H1]1CN(C(=O)CC2CSC2)CCN1C(=O)CCC(=O)NC3=NC=CS3 C[C@@H1](CNC(=O)C1=CC=C(N2CCCOCC2)C=C1)NC(=O)C(C)(C)N(C)C CCCC1=NC=C(C(=O)NC[C@]2(F)COCCN(C(=O)[C@H1]3CC(C)=NO3)C2)S1 C#CCN(C)C(=O)[C@H1](CC1CCOCC1)NC(=O)C2=CC=CC=C2Cl CCCNC(=O)[C@H1](CCCSC)N1CCC2=CC(CC)=CC=C2C1 O=C(N=C1[NH1][NH1]C=C1C2=CC=CN=C2)C(=O)N[C@@H1](CCC3=CC=CC=C3)C(F)F CN1CCO[C@H1](C(=O)NCC23CC(NC(=O)C4=CC(O)=NC=C4F)(C2)[C@@H1](C)O3)C1 CC1=NC=C(F)C(N2CCC[C@H1]([C@H1](C)NC(=O)COC3=CC=CC=C3)C2)=N1 CCCOC1=CC=CC=C1C(=O)N2CC(C)(NC(=O)[C@H1]3COCC(C)(C)O3)C2 COC(=O)C1=CC=C(NC(=O)C=2C=C(C3=CC=C(O)C=C3CO)[NH1]N=2)C(C)=C1 C[C@@H1](CC(=O)N[C@H1]1CCN(C(=O)C2=CSC(C3=CC=CS3)=N2)[C@H1](C)C1)C(F)F O=C(NC1=CC(Cl)=C(Cl)C=C1O)[C@H1]2[C@H1]3CC[C@@H1](C3)N2C(=O)[C@@H1](O)CC4=CC=CC=C4 CC(C)OCCC(=O)N1CC[C@H1](O)[C@H1](N(C)C(=O)CC2=CN=CN=C2O)C1 CCO[C@@H1]1CN(N2CCN(C(=O)CC(F)(F)F)C(=O)C2)C[C@H1]1CO CCN1CCC[C@@H1](NC(=O)[C@H1]2CCN2C(=O)C3=CC(C)=C(F)C=N3)C1 CCC[C@](C)(O)C(=O)NCC1=CC=CC=C1CN(C)C(=O)[C@H1](C)C=2C=CN(C)N=2 C[C@@]1(C(=O)NCCCNC(=O)C2=CC=CC=3OC=CC2=3)CCC(=O)N1 CS(=O)(=O)NCC(=O)NC[C@@H1](O)CNC(=O)C1=CC=NO1 CSC[C@H1](C)C(=O)N1C[C@@H1]2C[C@@H1](C)N(C(=O)C3=NN4C=CC=NC4=C3Br)[C@@H1]2C1 CNC(=O)C[C@@H1]1CN(C(=O)CC[C@H1](C)C#N)CCN1C(=O)C=2SN=C(O)C=2Cl CN=C1C=CC(C(=O)N[C@H1](CC(=O)N[C@H1](CO)C2CCCCC2)C(F)(F)F)=C[NH1]1 CC(C)[C@@H1](CO)NC(=O)[C@@H1]1CSCN1C(=O)C(C)(C)C(C)(F)F CN1N=CC(Br)=C1C(=O)N2[C@H1]3CC[C@@H1]2CN(C(=O)C#C[C@H1]4CCCCO4)C3 CC1(C)CC2(CC(C(=O)NC[C@H1](O)CCNC(=O)[C@H1]3C[C@@H1]4CC[C@@H1]4C3)C2)C1 CC1(C2=CC=C(F)C=C2)CCN(CC(=O)NC3=CN=C4C=CC=NN34)CC1 CCN(OC)C(=O)[C@@H1]1C[C@]12CCN(C(=O)C[C@@H1]3CCC[C@@H1]4C[C@@H1]34)C2 COC=1SC=CC=1C(=O)N2CC[C@@H1](C)[C@H1](CNC(=O)C3=CC=C(F)C=C3F)C2 CN(CCN(C)C(=O)[C@H1]1CC=CCC1)C(=O)CCC=2C=NN(C)N=2 CC1(C)CC(C(=O)N2CC3=CC=CC=C3[C@H1](CNC(=O)COCC(F)F)C2)=NO1 CC[C@@H1](C)CCCCC(=O)N1CCCC(C)(C)[C@@H1]1C(=O)N(CC)CCO COCC[C@@H1](OC)C(=O)N(CCNC(=O)C1=CCOC1)CCOCCO CC(=O)C1=CN(C)N=C1C(=O)NCCN(C)C(=O)C2CCC(C(=O)N(C)C)CC2 CCCCC[C@H1](O)CC(=O)N1CC[C@@](COC)(NC(=O)CC[C@@H1]2CC2(F)F)C1 C#C[C@]1(CC)COCCN1C(=O)C2=CC3=C(Br)C=CC=C3C(=O)O2 CNC(=O)C(C)(C)NC(=O)CO[C@H1]1CCN(C(=O)C2=CC=C(C#N)C=C2C)C1 CC(C)C(=O)N1CCC(NC(=NCC2CC2)NC[C@@]3(C)C[C@@H1]3Br)CC1 CC1=NO[C@@H1](C(=O)N[C@@]2(C(=O)NC3=CN=CN=C3CO)C[C@H1]2C)C1 C/C=C/C[C@H1](C)C(=O)NCC[C@H1]1CC(F)(F)CN1C(=O)C(CC(C)C)CC(C)C COC1=CSC=C1CN=C2[NH1]C(=N[C@H1]3C[C@@H1](OC(C)(C)C)C3)[NH1]C4=C2COCC4 CC(C)CCC[C@@H1][C@H1](C(=O)NCCN1CCOCC1)N2CCN(C3CC3)CC2 NCC1=CSC2=NC=C(C(=O)NC3(CO)CCC(C(F)F)CC3)C=C12 O=C(C=CC1CC1)NC[C@@H1]2CC3(CC3)CN2C(=O)[C@@H1](O)C4CC4 O=C(NC1CN(CC2=CC=CC(Cl)=C2)C1)N[C@@H1]3CCC4=C[NH1]N=C4C3 O=C(N[C@H1](CO)C(=O)N1CC(O)(CO)C1)C=2C=NN(C3CC3)C=2 CC1=C(C(=O)NCC2[C@H1]3CN(C(=O)C4=CN=CN=C4C)C[C@H1]23)OC=C1C(=O)CC C[C@@H1](SC1=CC=C(F)C=C1)C(=O)NCC2=CC=C(CNC(=O)[C@]3(C)C[C@H1]3C)C=C2 CC(F)(F)CCCNC1=NC=CC(=NCC=2C=C[NH1]N=2)[NH1]1 COCC1=NN=C(N2CC[C@H1](CNC(=O)[C@@H1]3CCCC4=NC=NN43)C(F)(F)C2)S1 COC(=O)COCC(=O)N1CCC[C@]2(C1)[C@@H1](NC(=O)CN3N=CN=N3)CCN2C N#CC1(C(=O)NC2CC3(CC(NC(=O)CN4CCNC(=O)C4)C3)C2)CCCC1 CCOC(=O)CC1=CC=NC(NC(=O)N[C@@H1](C)C2=NO[C@H1]3COC[C@@H1]23)=N1 CCC[C@@H1](NC(=O)[C@@H1](C)CNC1COCCOC1)C2=CC=CC=C2 CC(C)(C)OC(=O)N1CC2(OCC(=O)N3CC(NC(=O)CC(F)F)C3)CC1C2 CCC1CC(C(=O)N2CC(N(C)C(=O)[C@@H1]CC3C=NC(O)=C4C=NN(C)C4=N3)C2)C1 CCC1=CSC=C1C(=O)N2[C@H1](C(=O)NCCC3CCCCC3)CCC24CC4 CC(C)(C)OC(=O)C[C@@H1](O)C(=O)N[C@]1(CO)CCN(C(=O)CCCC2CC2)C1 C[C@@H1]1CC[C@H1](NC(=O)[C@@H1]2C=CCS2)CN1C(=O)CC[C@@H1]3CC(C)(C)CO3 COCC1=CC=CC=C1C(=O)NCC2(NC(=O)C3=CCC4(COC4)OC3)CC2 CC#CC1CN(C(=O)[C@@H1](CC2CCC2)NC(=O)C3CC(C4CC4)C3)C1 C[C@H1](C(=O)N(C)C1CC(NC(=O)/C=C/C2=CC=CC=C2)C1)N3CCN(C)CC3 CCN1N=NC=C1[C@@H1](N[C@H1]2CCCS(=O)(=O)C2)C3=NN=NN3C4CCOCC4 CCC(CC)[C@@H1](OC)C(=O)N[C@H1](C(=O)NCCCC1=NN=CS1)C2(C)CC2 CC1=NC=CN1CC(=O)NC[C@@]2(C)CCN(C(=O)C3=CC=C(Cl)C(N)=C3Cl)C2 CN(C(=O)C1=CN=CC([N+1](=O)[O-1])=C1)[C@H1](CNC(=O)[C@@H1]2C[C@H1](F)C(=O)N2C)C3CC3 C=CC=CCC(=O)N(C)[C@H1](C)CN=C1N=C(N2C=CN=C2)C=C[NH1]1 CC(C)C[C@@H1](CC(=O)NOC1CCCCC1)NC(=O)C2(N3C=CC=N3)CC2 C=C[C@@](C)(O)C(=O)N1CCC2(CCN(C(=O)C3=COC(C)=N3)CC2)[C@H1](C)C1 CN(C[C@@]1(C)CCC[C@@H1]1NC(=O)C2=CC(Cl)=N[NH1]2)C(=O)[C@@H1]3C[C@H1](N(C)C)CCO3 COC(=O)C1=COC=C1C(=O)N(C)CCN(C)C(=O)[C@@H1]2CCC[C@H1](C)C2 C[C@H1](CNC(=O)C1=CC(CNC(=O)CN2C=NN=N2)=CS1)C(F)(F)F C=CCCCC(=O)N1CC[C@H1]2CCC[C@@]21CNC(=O)C=CC3=CC=C(O)C=C3 O=C(C[C@H1]1CCN1C(=O)[C@@H1]2CC2(F)F)NC[C@@H1]3CCC=CO3 CC1=CC(C(=O)N2CCN3C(CNC(=O)C4(C)CC4)=NN=C3C2C)=CS1 COC1=CC=CC=C1OCCCN[C@@H1](C=2C=C(C)ON=2)C3=NN=NN3C(C)(C)C CCS[C@@H1](C(=O)N(C)C[C@@H1]1CCCN1C(=O)C2=CC=C(F)C=C2F)C(C)C C[C@@H1](C(=O)N1CC[C@H1]1CNC(=O)CCC2=CC=NN2C)N(C)C(=O)OC(C)(C)C N#CC1(C(=O)N[C@H1]2CC[C@@H1](O)CN(C(=O)C3=CN=CC(Cl)=C3)C2)CC=CC1 CC1(C)CN(C(=O)[C@@H1]2[C@H1]3CCC[C@H1]32)CC[C@@H1]1NC(=O)CC4=CN=C5C=CC=NN45 COC1=NC=C(CN[C@H1](C2=NN=NN2CCC3CC3)[C@]4(C)CC4(C)C)C=N1 CNC(=O)C1=CC[C@H1](NC(=O)C=CC2=CC=C(C(C)C)C=C2)C1 CC1=CN=C(CN2CCC(C)(CNC(=O)[C@H1]3CCCCC3(F)F)CC2)O1 CNCC1=NN=C(C(=O)N2CCN(C(=O)C34CCCC3CCC4)CC2)S1 CC(C)(C)OC(=O)N[C@@](C)(C(=O)N1C[C@H1]2CC[C@H1]1C2)C(F)F CNC(=O)N1CCC(C(=O)NCCNC(=O)CCC2=CN=C(C3CC3)O2)CC1 CCC1=NC=NC=C1C(=O)N[C@H1](C)CN(C)C(=O)CO[C@H1](C)CC CCC1=NC(C(=O)N2CCC[C@H1](CN(C)C(=O)[C@H1]3OCCO[C@H1]3C)C2)=C(C)O1 C=CCCO[C@@H1](C)C(=O)N1C[C@@]2(CNC(=O)C3CC(C)(C)C3)C[C@H1]1CO2 C[C@@H1](C(=O)N1CC2(CCCN(C(=O)CC3=CN=NN3C)C2)C1)C(C)(F)F C=CC(C)(C)CCNC1=CC=C(S(=O)(=O)N2CC=C(C3=CC=CS3)CC2)C(Br)=C1 CC(C)[C@@H1](C)C(=O)N1CCCC2(C1)CN(C(=O)CC=3C=NN4C=3CCCC4)C2 COC=1C=CSC=1C(=O)NC[C@H1]2C=CCN2C(=O)[C@H1]3C[C@@H1](C)CC(C)(C)C3 CC(C)C=1C=CSC=1C(=O)N2CCC[C@@H1](NC(=O)[C@@H1](O)C3=CC=CN=C3)C2 O=C(N[C@@]12CC[C@@H1](CN(C(=O)C[C@H1]3CCC3(F)F)C1)C2)C4=CC(O)=CC(=O)O4 CC1=CC(N2CCC[C@](C)(NC(=O)[C@H1](C)NC(N)=O)C2)=NC(C3CCC3)=N1 O=C(C[S@](=O)CCC(F)(F)F)NC/C=C/CNC(=O)[C@H1]1C[C@](F)(CO)C1 CN(C[C@H1]1CN(C(=O)[C@@H1]2CCCCC23CC3)CCO1)C(=O)C=CI CCN(C(=O)C1=CC=C(C(C)=O)N=N1)[C@H1](C)CNC(=O)/C(C)=C/C2=CC=CC=C2 CC(C)(C)OC(=O)N1CCC=C(C(=O)N[C@@H1](CC(=O)O)C2=CC=CC=C2)C1 CP(C)(=O)[C@@H1]1CCC[C@H1]1C(=O)N2CC3(CN(C(=O)CSC4CC4)CCO3)C2 CC=1SN=NC=1C(=O)NC[C@@H1]2CC[C@H1](NC(=O)CC3=CC=C(CO)C=C3)C2 C[C@@H1](NC(=O)C1=CC(=O)N(C)C=N1)[C@H1]2CN(C3=CC(F)=NC=N3)CCO2 C[C@H1](NC(=O)C1(CO)CC1)C2CN(C(=O)[C@@H1](C)N3C=CC(C4CC4)=N3)C2 C=CCO[C@H1](C)C(=O)N1CCN(CC2=CC=C(F)C(C(=O)O)=C2)C[C@@H1]1C#N CSC=CC(=O)N1CCC2(CC1)CN(C(=O)C(=O)N3CCC[C@@H1](C)C3)C[C@@H1]2CO CCN(C[C@H1](C)NC(=O)[C@@H1]1CC(C(C)(C)C)=NO1)C(=O)C23C4C5C2C6C3C4C56C CCC(C)(C)CC(=O)NCC[C@]1(O)CCN(C(=O)[C@@H1]2CC[C@H1](C(F)(F)F)O2)C1 CC(C)CC[C@@H1](C)NC(=O)CSCCNC(=O)[C@@H1]1COC[C@H1]1C(N)=O COC(=O)C1=NC=C(CNCC2(CC3=CC=CC=C3)CCCCC2)C=C1C CCCCCCCCCCCCC(=O)OC1=CC=C2C(=C1)CC[C@H1](C)O2 CC=1C=C(CC(=O)N2CCC3(CC2)C[C@@H1]3C(=O)N[C@@H1]4C[C@@]4(C)C(F)F)ON=1 CC1=CC(C2=CC(F)=C(C)C=C2N)=CN1CC3=CC=CC=C3 CCC1=CC(C(=O)N[C@H1]2CN(C(=O)CC=3N=CN4C=3CCCC4)CC2(C)C)=N[NH1]1 C[C@H1](C(=O)N[C@@]1(C(=O)N(C)CC2(CO)CC2)CC1(C)C)C3CC3 C=CCC(F)(F)C(=O)N1CCC[C@@H1](C2CN(C(=O)C3=CC(O)=NC=C3F)C2)C1 CC1=C(CC(=O)N[C@H1]2C[C@@H1](CO)N(C(=O)C3=CC=C([N+1](=O)[O-1])O3)C2)C=NN1C C[C@H1](C(=O)N[C@@H1]1C[C@@H1](C)CN(C(=O)C=2C=C(C3CC3)SN=2)C1)N4C(=O)CCC4=O C[C@@H1](CO)C(=O)NCC[C@@H1](C)NC(=O)C1=C[NH1]C=C(F)C1=O COCC(C)(C)NC(=O)C1=N[NH1]C=C1NC(=O)C2=CC=C(CO)C(F)=C2 C#CC1(O)CC(C(=O)NC[C@H1](O)CN(C)C(=O)CCC23CCC(CC2)C3)C1 COC1=CC(C(=O)NC[C@@H1](CO)NC(=O)C=2N=NN(C)N=2)=CC3=C1OCCO3 CCCCC[C@@](C)(N[C@H1]1C[C@@H1]2C[C@H1]1C[C@@]2(C)O)C3=NN=NN3C4=CC=CC=C4C CC1=C(CC(=O)N[C@H1]2CC[C@H1]2CNC(=O)CC3CN(C)C3)C=CC=C1[N+1](=O)[O-1] CCOCCOCCC(=O)NC[C@@H1]1CC[C@@H1]1NC(=O)[C@@H1](O)C2=CC(F)=CC(F)=C2 N#C[C@H1]1CC[C@H1](NC(=O)C23CC(NC(=O)C4=CC=CC=5C=COC4=5)(C2)C3)CC1 O=C(NCCN1C=CN=N1)[C@@H1]2C=CCN(C(=O)[C@@H1]3CC=C[C@H1](O)C3)C2 O=C(NC[C@H1]1CCCN1CC2=CC=CN3C=CN=C23)C4=CC(Br)=NC=C4F CO[C@H1](CNC(=O)C=C(C)C)CNC(=O)C1=C(N)N=NC(C)=C1C O=C(NCC[C@H1]1CCCCN1C(=O)[C@@H1]2C[C@@H1]3C=C[C@H1]2CC3)C4CC=CC4 CC1=CC(C)=C(S(=O)(=O)N2CCOC[C@@H1](NC3=NC=NC=4[NH1]C=C(C)C3=4)C2)C(C)=C1 COC1=NC=C(C(=O)N[C@H1](CNC(=O)C2=C(F)C=C(F)C(F)=C2F)C(C)C)C=N1 COC1=CC(OC)=C(NC(=O)C[C@@H1]2CN(CC3=CC(Br)=CO3)CCO2)C(OC)=C1 O=C(C[C@H1]1C=CCC1)N2CCC(C3CC(NC(=O)C4=NN=C(O)C=C4O)C3)CC2 C[C@@]1(CC(=O)N2C[C@@H1]3C[C@H1](C2)C3NC(=O)[C@H1]4CC5(CCOCC5)CO4)CCCO1 CC(C)C1=CON=C1CC(=O)N[C@H1]2CC[C@H1](NC(=O)[C@@H1](C)SC(F)(F)F)C2 CC[C@@H1](CNC(=O)CCCC(C)C)NC(=O)C1=CC=CC2=CC(F)=CC=C12 C[C@H1](C(=O)NCC(C)(C)CC1CN(C(=O)C2(Cl)CC2)C1)[C@H1](C)C(C)(C)C CC(C)(C)[C@@H1]1C[C@H1]1C(=O)N2CC(=O)NC[C@@H1]2C(=O)N3CC[C@@H1](C4=NOCC4)C3 CCC1=CC=CC=C1CNC(=O)[C@](C)(C2CC2)N(C)C(=O)C3=CN=C(O)C=C3C C[C@H1](NC(=O)C1=C(CNC(=O)[C@]2(C)C[C@H1](O)CN2C)N=NN1C)C3=CC=CN=C3 CO[C@H1](C)[C@@H1](C(=O)NC(C)(C)C[C@@H1](F)C(=O)NCC=1C(C)=N[NH1]C=1C)N(C)C CCN(C[C@H1](C)NC(=O)CC1=CN=C2N1CCOC2)C(=O)C3=NC=CC=C3Br CS[C@@H1](C)CNS(=O)(=O)C1=CN=C(NCCN(C)C2CCCC2)C(Cl)=C1 CO[C@H1]1CN(C(=O)COCCN2N=CC=C2C)CC[C@H1]1NC(=O)CC(C)(C)C CO[C@H1](C)C(=O)NC[C@@]1(OC)CCN(C(=O)[C@H1]2CCC3=N[NH1]C=C3C2)C1 COC1=CC=C(N2CCNC2=O)C=C1NC(=O)C=CC3=CC=C(OC(C)(C)C)C=C3 CCCC[C@@](C)(F)C(=O)N1CC([C@@H1](F)CN2C=C(COC3=NC=CC=N3)N=N2)C1 CC1=NC2=NC=C(C(=O)NC[C@@H1]3C[C@@H1]4C[C@H1]3CN4C(=O)C[C@@H1]5CCOC5)C=C2O1 OC1CCN(C2=CC=CC(NCC3=CC=C(Cl)C=C3[N+1](=O)[O-1])=C2)CC1 COC1=C(N)N=C[NH1]C1=NCC=2N=C(Br)SC=2C(F)(F)F CCC1=CN=C(O)C(C(=O)N(C)C[C@H1]2COCCN2C(=O)[C@@H1]3CCOC3(C)C)=C1 O=C(NCC#CC1=CN(C[C@@H1]2CCCOC2)N=N1)[C@H1]3C[C@H1]3F CC(C)C[C@@H1](C)C(=O)NC[C@@]12CC[C@@H1](C1)N(C(=O)C3=C(O)C=C(Cl)C=C3F)C2 CC1=CC(C)=C(CC(=O)NC2=NC3=CC=CC(Br)=C3S2)C(C)=C1 CCCCC1(C(=O)N2C[C@H1](O)[C@H1](NC(=O)C=3N=COC=3CC)C2)CCC1 C#CC#CC(C)(C)NC(=O)/C=C/CNC(=O)[C@@H1](C)NC(C)=O CC[C@H1](C)N1CCN(S(=O)(=O)C2=NC(N(C)CC3(COC)CCCC3)=CC=C2Br)C1 CCOC1CC(CC(=O)N2CCCC[C@H1](C3CN(C(=O)[C@H1](O)C(C)C)C3)C2)C1 CC(C)N1N=CC(C(=O)N2C[C@H1]3[C@H1](NC(=O)C4=CC=C(F)S4)[C@H1]3C2)=N1 CC1(C(=O)N2CCC3=C(C(CNC(=O)C(F)(F)C(F)(F)F)=NN3C)C2)CSC1 COC1=C(Br)SC(C(=O)N2CCO[C@@H1](CNC(=O)C[C@@H1]3CCCOC3)C2)=C1O CCCOCC(=O)N1CCN(C(=O)[C@@H1]2C[C@H1]3CC[C@H1]2C[C@H1]3OC)C[C@H1]1COC CC(=O)NC1CN(C(=O)[C@@H1]2C=CCCN2C(=O)C=3C=C4C=CC=CN4C=3)C1 O=C(CN1C=C(Cl)C=N1)N[C@H1](CC2=CC=C(Cl)C=C2)C3=CC=CC=C3 CCCC=1N=COC=1C(=O)N(C)[C@H1]2CN(C(=O)[C@@H1](CCSC)OC)CC23CC3 CCN1N=C(COC(C)(C)C)N=C1C2=CC(F)=C(F)C=C2F C=C[C@H1]1CN(C(=O)[C@@H1](C)OCCOC)C[C@H1]1NC(=O)C=C2SCC(=O)N2C CCC=1SC(C(=O)NC[C@H1]2C[C@H1](CNC(=O)[C@@H1](C)CSC)C2)=CC=1Br CCCN(CCC)CCCC(=O)N1CCC[C@](O)(CCNC(=O)CCC(F)F)C1 CC=1C=C(C(=O)N[C@@H1]2CC23CCN(C(=O)C4=N[NH1]C(C)=C4[N+1](=O)[O-1])CC3)SC=1C COC[C@@]1(NC(=O)C2=CN(C)C=C2C)CCN(C(=O)C=3C(C)=COC=3C4CC4)C1 CCCCN(C)C(=O)[C@@H1]1C[C@H1](C)N1C(=O)[C@H1](OC)C(CC)CC C[C@H1](OCCN(C)C)C(=O)NC1(CNC(=O)C2CCS(=O)CC2)CCC1 CC=1OC=CC=1C(=O)NCC2=CC=C3C(=C2)CN(C(=O)CSC4=NN=CS4)C3 O=C(NC12CC(C(=O)NC[C@H1]3C[C@@H1](CO)C3)(C1)C2)C4=C(Cl)CCC4 CC1(CNC(=O)[C@@H1]2CNC(=O)C2)CCN(C(=O)CCN3C=C(Cl)C=N3)CC1 CCCCC[C@@H1]1CC[C@H1](C(=O)NC[C@@H1]2C[C@H1](C)CCN2C(=O)CCN(CC)CC)O1 CCO[C@@H1](CC(=O)N[C@@H1](CC)CN(CC)C(=O)C=C=C(C)C)C(C)C C#CCSCC(=O)N1C[C@H1](C)CC[C@@H1]1CNC(=O)C2CCN(C3CC3)CC2 CC=1[NH1]C(C#N)=CC=1C(=O)NC[C@H1](C(=O)NN2C=CC=N2)C(C)(C)C CCN1CCC[C@H1]1CC(=O)N2C[C@@H1]3C[C@H1](C2)C3NC(=O)[C@@H1](OC)C4=CC=CC=C4 COC1=CC=C(S(=O)(=O)NCC(=O)NCC(C)(C)CO)C(F)=N1 CC=1[NH1]N=C2C=CC(N[C@H1](C3=NN=NN3C4=CC=C(F)C=C4)C(C)(C)S)=CC=12 CN(/C=C/C1=CC=C2C(=C1)OCCCO2)C(=O)N[C@H1]3CCOC(C)(C)C3 CCCCOCC(=O)N1C[C@@H1](C)CN(C(=O)C2=CN=C(C(C)(C)C)S2)C[C@@H1]1C C[C@H1](NC(=O)/C(F)=C/CCF)[C@H1]1CCCCN1C(=O)C=2C=CC3=NN=C(O)N3C=2 CC1=CC(=NC(=O)C2=CC=C3C(=C2)CCC(=O)N3)[NH1]N1C4=CC=CC=C4 CC(C)[C@](C)(CNC(=O)[C@H1]1CCOC(=O)CC1)NC(=O)C2=CC=C(Cl)C=N2 CC[C@H1]1CN(C(=O)C2=CC(C)=C(Br)O2)CCN1C(=O)NC3=CC=CC=C3 COC1=CC=CC=C1C(=O)N[C@H1]2C[C@@H1]3C[C@H1]2C[C@@H1]3C(=O)NCC4(Cl)CCC4 CCN1N=C(C)C(C(=O)N2CC[C@]3(CCN(C(=O)C4(O)CCCCC4)C3)C2)=C1Cl CCN1N=C(C)C(C(=O)N(CCCNC(=O)[C@@H1](C)[C@@H1]2CCC(=O)N2)C3CC3)=C1Cl C[C@H1](N=C1N=C(C(F)F)N=C(Cl)[NH1]1)[C@@H1]2CCCN(C(=O)C[C@@H1]3COCCO3)C2 CCC[C@](C)(O)CC(=O)N1CCC[C@@]2(CNC(=O)C3=CN(CCO)N=N3)C[C@H1]12 CN1N=NC=C1CC(=O)N2CCO[C@](C)(CNC(=O)[C@@H1]3CCCC4(CCC4)C3)C2 C#CC1(O)CN(C(=O)[C@H1](CC)N(C)C(=O)CC=2C=NN(C)C=2)C1 CCNC1=CC=C(Cl)C=C1C(=O)NCC2CN(C(=O)C3=CN=C(C)[NH1]3)C2 CC(=O)C=1C=C(CCC(=O)N[C@@]2(C)CCN(C(=O)/C(F)=C/CCF)C2)OC=1C CC[C@](C)(CNC(=O)[C@@H1](C)N1CCCCC1=O)NC(=O)CCC2CCN(C)CC2 C[C@@H1](C1=CSN=N1)N2CCN(C(=O)CCC3=CC=CS3)[C@@H1](C)C2 CC(=CC(=O)NCCOCCN(C)C(=O)[C@@H1]1CCC12CCC2)C3=CC=CN=C3 CS[C@H1]1C[C@H1](C(=O)NC[C@H1]2CCC[C@@H1]2NC(=O)C3=CC=CC=C3C4CCC4)C1 O=C(C1=CC(F)=C[NH1]1)N2C[C@@H1]3CN(C(=O)[C@]45CCC[C@H1]4C5(F)F)C[C@H1](C2)O3 CCC1=NC(CNC(=O)N2CCC([C@H1](O)C3=CC=C(Cl)C=C3)CC2)=CS1 CC1(C)CCC(C(=O)N[C@]23CCC[C@H1]2N(CCOCC(F)(F)F)CC3)CC1 COCCCC[C@@H1](N[C@H1](C)C1=NC=CC=N1)C2=NN=NN2CCSC CCC1C=NC(C(=O)N(C2CC2)[C@H1]3CCCC4=CC=CC=C4C3=O)=CO1 COC1=CN=C(CN2CC[C@](O)(C(=O)NC3=CN=CC(Cl)=C3)C2)C=N1 CC[C@@H1](CC(F)(F)F)C(=O)N[C@@H1]1CCC[C@H1]1NC(=O)CN2C=NC=CC2=O COC1=CC(Br)=CC=C1[C@@H1](CO)NC(=O)N(CC2=CC(Cl)=CC=C2Cl)CC(C)C C[C@@H1]1CN(C(=O)C[C@H1]2CCCOCC2)C[C@]3(CCN(CC4=NC=C(Br)S4)C3)O1 CC1=NN=C(CC(=O)NC(C)(C)CNC(=O)C=C2C3CC4CC(C3)CC2C4)S1 O=C(C1=CC=NC(Cl)=N1)N2CCO[C@@H1](CNCC3=CC=C(CBr)C=C3)C2 O=C(NCCS(=O)(=O)CC1=CN(CC=2C=C(C3CC3)ON=2)N=N1)C4=CSC=C4Cl O=C(C1=CC=C(NS(=O)(=O)C2COC(CF)(C2)CO)C=C1)C(F)(F)F C[C@@H1]1CN(C(=O)C(N2C(=O)C3=CC=CC4=CN=CN34)CC(F)(F)C2)CC[C@@H1]1O CC(C)(C)C(=O)N1CC[C@@H1](C(F)(F)F)[C@H1](NC(=O)CNC(=O)C2=CC=CS2)C1 CCCC[C@@H1](NC(=O)CCCF)C(=O)N1CC2(CCCC2)C[C@H1]1C COC[C@@H1](C)CC(=O)N1CC=C[C@@H1]1CNC(=O)C2=CC3=C(S2)CC(C)(C)C3 CC(C)CN=C1N=C(N2CCC(S(=O)(=O)N(C)C)CC2)C=3N=CN(C)C=3[NH1]1 C#CC(C)(C)C(=O)NCC1=CC=C(N2CCN(C(=O)C3=CC(C)(C)C3)CC2=O)C=C1 CC[C@H1](C)C(=O)N1C[C@@H1](NC(=O)C2CN(C)C2)C[C@H1]1C O=C(CC1=CC=CC=C1O)N2CC[C@](F)(CNC(=O)C3(C4CC4)CC3)C2 O=C(C[C@H1]1CCOC1)NCCC2CN(C(=O)[C@H1]3C[C@@H1](O)C3)C2 CCCC[C@H1](O)C(=O)N1CC(F)(CNC(=O)CCSC2CCCC2)C1 N#CC=1C=CC(=NCC(=O)N[C@@H1]2CCCN(C(=O)CN3CCCCCC3)C2)[NH1]C=1 CC(C)[C@@H1](O)C(=O)N1CC[C@](CO)(NC(=O)[C@H1]2C[C@@H1](NC(=O)OC(C)(C)C)C2)C1 CC[C@@H1](O)[C@H1](C)C(=O)NC(C)(C)CNC(=O)C=1C=NOC=1C=2C=COC=2 CC[C@@H1](C)[C@H1](O)C(=O)NCCCN(CC)C(=O)C1=CC=NC2=NC=NN12 CC1=NC(CC(=O)NC[C@@H1]2C[C@H1]3CC[C@H1]2N(C(=O)C=4SC=CC=4C(F)F)C3)=N[NH1]1 CO[C@@H1]1C[C@@H1](CNC(=O)C2=CC=CN2C)N(C(=O)[C@@H1]3CC(C4CC4)=NO3)C1 CC1=CC(C)=NC(C(=O)N[C@@H1](C)CCCNC(=O)C[C@H1]2C[C@@H1]2C3CC3)=C1 CC=1SC(C2=CC=C3N=CSC3=C2)=NC=1C(=O)NC4=CC=CN5N=CN=C45 CCC1=CC=C(CNC(=O)CC[C@H1](NC(=O)[C@H1](O)C2CCCC2)C(C)C)N=C1 C[C@@H1](O)C(C)(C)C(=O)NCC[C@H1]1C[C@@H1](NC(=O)[C@](O)(C=2C=N[NH1]C=2)C(F)(F)F)C1 O=C(N[C@@H1]1CN(C(=O)C=2SN=CC=2Br)C3(CCC3)C1)[C@H1]4CCCC45CC5 CN1C=C(OCC(=O)N2CC[C@H1](NC(=O)C3(F)CCCCCC3)C24CC4)C=N1 C=C(C)CC(=O)NC[C@@H1]1CC12CCN(C(=O)[C@H1]3CC[C@H1](N(C)C)CC3)CC2 C[C@@H1]([C@@H1]1CCCO1)N(C)C(=O)C2=C[NH1]N=C2CCNC(=O)C3=C(O)C=CC=C3F CC1=CC=CC(C)=C1NC(=O)[C@H1]([C@@H1]2C[C@@]2(C)Br)N(C)[C@H1](C)CN3CCOCC3 COCC1(CNC(=O)C2=CC(C)=NC(C)=N2)CN(C(=O)[C@@H1]3C[C@@H1]3C(=O)OC)C1 C[C@H1]1CCN(C(=O)C2=CC=NC=N2)C[C@H1]1NC(=O)C3CS(=O)(=O)C3 CC1=CSC(=O)N1CCC(=O)N[C@@H1](C)[C@@H1](CO)NC(=O)C2=CC3=NC=CC=C3O2 CO[C@@H1](CNC(=O)C=1[NH1]C=CC=1CNC(=O)C2=CCOCC2)CC3CC3 COC1=CC=C2N=C(NC(=O)CC3CN(CC4=CC=CC5=NON=C45)C3)SC2=N1 CCC=1SC=NC=1C(=O)N[C@@H1]2CCCC[C@@H1]2NC(=O)[C@@H1](C)SC3=CC=C(F)C=C3 C=C(C)C[C@H1](OC)C(=O)N1CC[C@H1](O)C[C@@H1]1C(=O)NCC[C@H1]2CCN(C)C2=O C[C@H1]1CCCCN1CCNC(=O)C2(NC(=O)[C@@H1]3CCC(=O)O3)CC(CO)C2 O=C(N[C@@H1]1C[C@H1]1CNC(=O)[C@H1](O)C2=CC=C(Cl)C=C2F)C3=CN=C(C4CC4)[NH1]3 O=C(N[C@]12CCN(C(=O)C3=CC=CN=C3SC(F)(F)F)C[C@H1]1C2)C4CCOCC4 O=C(NC1CN(C(=O)C2=CN([C@H1]3COC[C@@H1]3O)N=N2)C1)[C@@H1](F)CC4=CC=CC=C4 CCNC(=O)[C@H1]1CCCN1C(=O)CC[C@H1]2CCN(C(=O)C3=CC=CC(C#N)=C3)C2 CCC1=NC=C(C(=O)N[C@@H1]2C[C@H1](OC)CN(C(=O)C#CC(=O)N(C)C)C2C)S1 COC(=O)CC1=CC=CC(C(=O)N[C@H1](C)[C@H1](C)NC(=O)CC2(C)CCCCC2)=C1 O=C1CSC2=CC(C(=O)N[C@H1]3CCN(C(=O)C=4C=N[NH1]C=4)C[C@@H1]3F)=CC=C2N1 C=C1C[C@H1]1C(=O)NC[C@H1]2CN(C(=O)CC=3C=C(C)[NH1]N=3)CC2(F)F C=CC[C@H1](CC)C(=O)N1CC=C[C@H1]1CNC(=O)CC2=NN=C(S)N2C CCCCCC[C@H1](C)CC(=O)N1CC(F)(C2=CN(CCN3CCOCC3)N=N2)C1 C[C@@H1](NC(=O)CC[C@@H1]1CCCO1)C2(O)CN(C(=O)CN3CCCCCCC3=O)C2 O=C(N[C@@H1](CNC(=O)C(F)(F)C1=CC=CC=N1)[C@@H1]2CCOC2)C=3C=NSC=3 CON(C)CCN=C1C=CN=C(N(C)CC2=CC=CC=C2S(N)(=O)=O)[NH1]1 CCC[C@H1](CC)[C@H1](C(=O)NC1=CC=CC=C1Cl)N2CCN(CC(F)F)[C@@H1](CC)C2 N#CC1=CC=C(O)C(CN2CCS[C@H1](C(=O)N3CC4=CC=CC(Cl)=C4C3)C2)=C1 C[C@H1]1C[C@H1](CN=C2[NH1]C3=NC=C(Cl)C=C3S2)CN1C(=O)C4=CC=CC([N+1](=O)[O-1])=C4 CC[C@](C)(Cl)CNC(=O)[C@H1]1[C@@H1]2C[C@H1]1CN2C(=O)C3=CC(C(C)=O)=C[NH1]3 CO[C@H1](CNC(=O)C1=CC=C2C(=O)C=C[NH1]C2=C1)CNC(=O)[C@H1](C)C(C)(F)F CC1=CC=C(C)C(C(=O)N[C@H1]2CCO[C@H1]2C(=O)NCC3=NN=CN3C4CC4)=N1 CCC=1N=C[NH1]C=1C(=O)N2C[C@H1](C3CC3)[C@@H1](NC(=O)CCNS(C)(=O)=O)C2 CCC1=C[NH1]C(C(=O)N[C@@H1]2[C@H1]3CCN(C(=O)CCN4C=CN=N4)C[C@H1]32)=C1 C[C@@H1](CC(=O)N1CCN(CCC(=O)N[C@@H1]2CC23CCC3)CC1)C4CC4 CCN1N=C(C(=O)N2CC[C@@H1]([C@@H1](C)NC(=O)C3=CC=C(Cl)N=C3Cl)C2)C=CC1=O O=S(=O)(C1CC1)N2CC3(C[C@H1]3C(=O)NC[C@@H1]4CCN(C5=CC=CC=C5)S4(=O)=O)C2 CC(C)N1C=NC(C(=O)N[C@]2(C)CCCN(C(=O)CC(C)(C)F)C2)=N1 NC(=O)C(=O)NC1(CN2CCN(C(=O)C=3C=C4C=CC(Cl)=CN4C=3)CC2)CC1 CC(C)(F)C(=O)N1[C@@H1]2CN(C(=O)[C@@]3(CO)CC3(F)F)C[C@@H1]2C[C@H1]1C C#CCO[C@H1](C)[C@@H1](NC[C@@H1](CO)CC(C)(C)C)C(=O)OCC CC[C@@H1](CN1C=NC=N1)NC(=O)[C@H1]2[C@@H1]3C[C@H1]2CN3C(=O)C4(C)CCSCC4 COCCC[C@@H1](C)C(=O)N1CC(C[C@H1](C)NC(=O)C2CC3(C2)CC4(CC4)C3)C1 C[C@@H1]1CCN(C(=O)C2=CC=C(N)C=C2Br)C[C@H1]1CNC(=O)C#CC3(C)CC3 CO[C@@H1](CNC(=O)CCC1=CN=N[NH1]1)CC(=O)NC[C@@H1](C)OC(F)F COCCC1=NSC(N2CCC[C@](CO)(NC(=O)C3=CN=C4SC=CN34)C2)=N1 CSCC1=CC=CN=C1C(=O)NNC2=CC=CC=C2Br C[C@@H1](NC(=O)C1CCCCC1)C(=O)N[C@H1]2C[C@@H1](NC(=O)C3=NOC=C3Br)C2 CC[C@@H1](C)/C=C/C(=O)N[C@H1]1CCC[C@]1(C)NC(=O)C=2OC=C3C=2CCC3 CC1=CN=C(CC(=O)N2CC[C@@H1]2CNC(=O)/C(Cl)=C/Cl)[NH1]1 C#CCC1(C(=O)N2CCC[C@H1](CNC(=O)C3=C(C)N=C(C(C)(C)C)N=C3)C2)CC1 [N-1]=[N+1]=NC1(C(=O)N2CC(O)(CNC(=O)C3=CN(C[C@H1]4CCCOC4)N=N3)C2)CC1 N#CC1=CC=NN=C1N2CC3(CCC[C@H1]3NC(=O)C[C@H1]4OCC5=CC=CC=C54)C2 CCC1=CC(C(=O)N2CCC[C@@H1](C(=O)N[C@@H1](C)C(CC)CC)CC2)=NN1C CC(C)(C)C=NS1C(N2CCC[C@H1](NC(=O)[C@H1]3CC(=O)N(C(C)(C)C)C3)CC2)=N1 O=C(NCCC[C@H1]1CCCN1C[C@H1]2CCOCO2)C3=CSC(C4=NC=C[NH1]4)=N3 O=C(N[C@@H1]1CN(C(=O)[C@H1](F)C(F)(F)F)C2(CCCC2)C1)C=3OC=NC=3C(F)(F)F CC[C@H1]1CN(C(=O)C2=CN3C=CN=C3C=N2)CCN1CC4=CSC=N4 CC=1N=CSC=1C(=O)NCC=CCN=C2[NH1]C3=C(C=C2C#N)COC3 CC(=CC1=CC=CS1)C(=O)NC[C@H1]2CN(C(=O)CCC3=NN=CS3)C[C@H1]2O CC=1[NH1]C(C)=C(C(=O)NC[C@@]23CC[C@@H1](CN(C(=O)CN(C)C(C)C)C2)C3)C=1C CO[C@@H1]1CN(C(=O)[C@@H1]2CCO[C@H1]2C(F)(F)F)C[C@@H1]1NC(=O)C(C)(C)S(=O)(=O)C3CC3 CC(Cl)=CC(=O)N1C[C@@H1]2[C@@H1](C[C@H1]2NC(=O)CC=3N=CN4C=3COCC4)C1 CC1=NC=CC=C1CCC(=O)N(C)CCN2C=C(C3=CC=C(Cl)S3)N=N2 CSCC1(CCN[C@@H1]2CCCC[C@H1]2OC(C)C)CC1 CCCOCC(=O)N1CC[C@H1]1CNC(=O)CS(=O)(=O)NC2CC2 C=CC(C)(C)N[C@]1(C2=NN=NN2CCCOCC3CC3)CCC(C)(C)[C@@H1](C#N)C1 COC(=O)[C@H1]1C[C@H1]1C(=O)NOCC(=O)N2CCC([C@H1](C)CO)CC2 CCOC(=O)NCCCC(=O)NCC[C@@H1]1CCCN(C(=O)C=2SC=CC=2OC)C1 CC1=CC2=C(C=C1C)[C@@H1](C(=O)N3CCCN(C(=O)[C@@H1]4CCC(=O)C4)[C@H1](CO)C3)CO2 CC(C)NC(=O)CN(C)CC(=O)N1CC2(CC(CNC(=O)[C@H1]3CCO[C@@H1]3C)C2)C1 CC=1C=C(C(=O)N(C)[C@@H1](C)CN(C)C(=O)C2=CC(Cl)=N[NH1]2)N(C(C)(C)C)N=1 C[C@H1](CC(=O)N[C@H1]1C[C@@H1](CO)N(C(=O)C2=CC=C(Cl)C=N2)C1)N3C=CN=C3 CC1C[C@@H1]2CC[C@H1](C1)N2[C@H1](C(=O)NC3CCCCC3)C4=CN=C(Br)N4C CCN(CC(=O)N[C@@H1]1CC[C@H1]2CC[C@H1]21)C(=O)CC[C@H1](C)OC CO[C@H1](C(=O)N(C)[C@H1]1CCN(C(=O)C2=CSC3=C(Cl)C=CC=C23)C1)C4CC4 CC[C@H1](CC(=O)N1CCN(C(=O)C2=NC=C(C)C=C2F)[C@H1](CO)C1)SC CCN1C=C(C(F)(F)C(=O)NC[C@]2(C)CCCN(C(=O)CN=S(C)(C)=O)C2)C=N1 C[C@@H1]1CSCCN1C(=O)[C@@H1]2[C@H1]3C[C@H1](O)[C@H1](C3)N2C(=O)CCCCC#N C[C@@H1](O)CCC1=CN(C2=CC=C(C(=O)NCC3=CC=C(Cl)C=C3)C=C2)N=N1 CCN1CC[C@H1](C(=O)NC23CC(C(=O)NCC4=CC=C(O)C=C4F)(C2)C3)C1 C#CCCN(C)CC(=O)NCC12CCC(CC1)N2C(=O)C=CCOCCCOC C[C@H1]1CC2(CCCC2)CN1C(=O)C3(C4CC4)CN(C(=O)C=5C=NSC=5)C3 CC[C@@H1](SC)C(=O)N1[C@@H1](C(=O)NC[C@@H1](O)CC2CCCC2)[C@@H1]3C[C@@H1](O)[C@H1]1C3 CC(C)C[C@H1]1C[C@@H1]1C(=O)N2CCCC[C@H1]2C3=NC=CC(OC4CCOCC4)=N3 O=C(N[C@H1]1C[C@@H1](CNC(=O)C2=C(F)C=CC3=CC=NC=C23)C1)C4=CCCC4 CN(CCCCN(C)C(=O)C1=CC=C(F)S1)C(=O)C=2C=CN3C=CC=CC=23 CN(CC(=O)N1C[C@H1](NC(=O)CN2N=CC=N2)[C@H1]3CCC[C@@H1]31)S(C)(=O)=O CC1=CC(CC(=O)N2[C@](C(=O)NC3=CC=C(C4CC4)N=C3)C[C@H1](O)C2)=CS1 CCCN1N=NN=C1[C@H1](N[C@H1](C)C2(C)CCOCC2)C3=NC=NN3C CC=CC(=O)N1CCN(C(=O)[C@H1](OC(C)=O)C2=CC=CC=C2)C[C@@H1]1C(C)C CC(C)C=1OC=NC=1C(=O)NCCCCCNC(=O)C2CCN(C)S2(=O)=O CCNC(=O)N1CCC(C(=O)N[C@@H1]2CCN(C(=O)C3=CN(C)C=N3)[C@H1](C)C2)CC1 COC(=O)C(C)(C)C(=O)NCC1(O)CC(C(=O)N2CC[C@@H1](C)C2)C1 COC(=O)C=1SC(NC(=O)[C@H1]2CCCCN2C(=O)[C@@H1](O)C(C)C)=CC=1C CCO[C@H1](C)C(=O)NC1(CNC(=O)[C@@H1](C)CC2=CN=CO2)CC3=CC=CC=C3C1 C=CC(C)(C)C(=O)NC[C@@H1]1CCN(C(=O)C2=CN=C3C(=C2)C(C)=NN3C)C14CC4 CCC1(C(=O)N[C@H1](C)[C@@H1]2CCCN2C(=O)C=3[NH1]N=C([N+1](=O)[O-1])C=3Cl)CC1 CCC(=CC(=O)N1CC[C@H1]([C@@H1](F)C(=O)NC[C@H1]2COCC2(C)C)C1)CC CC[C@H1](CNC(=O)C1CN(C(N)=O)C1)NC(=O)C2=CC=C3OC(=N)[NH1]C3=C2 CC=1C=NSC=1C(=O)N[C@@H1]2COC3(CNC(=O)C4=CC=CN4C(C)C)CC2C3 C[C@H1](CCNC(=O)[C@@H1]1CCCC2(CC2)C1)N(C)C(=O)CN(C)S(C)(=O)=O CC1(C)CC(CCNC(=O)CC[C@H1]2CCCCN2C(=O)C3=CCCC3)C1 C[C@H1]1COC2=C(C(=O)N[C@H1]3CCN(C(=O)CSCCC#N)C3)C=CC=C21 C=CCN1C=C(C(=O)N2CCC(CC(=O)NCC(C)(C)CO)CC2)C=N1 CC=1N=C(C)N(CC(=O)N2CC3(CCC[C@H1]3NC(=O)[C@@H1](C)C4CCCC4)C2)N=1 C[C@@]12CC[C@@](C)(O1)[C@H1](C(=O)OCC3=CC(Cl)=CC=N3)C2 C=CCCSCCNC(=O)[C@H1]1CN(C(=O)[C@H1](O)CSC)CCO1 CC1=NC=CC(C(=O)N[C@H1]2CCN(C(=O)C3=NC4=C(S3)CN(C)CC4)[C@@H1]2C)=C1Cl CP(C)(=O)C1(C(=O)NCC2CC(O)(CNC(=O)C=3C=COC=3C4CC4)C2)CC1 CN(CCCCC(=O)NCC(F)(F)Cl)C(=O)C(F)(F)CO C=C[C@H1]1CN(C(=O)C=2C=C[NH1]C3=NC=CC=23)C[C@H1]1NC(=O)C[C@H1]4CCCC4(F)F COC1=CC=C(CC(=O)N(C)C[C@]2(O)CCN(C(=O)[C@H1](O)C(C)C)C2)N=C1 CON(C)CCNC(=O)C(=O)N1CCC2=NOC=C2C1 CC1=NC=NC=C1C(=O)NCC2CCN(C(=O)C3=CC(Br)=NC(Br)=C3)CC2 NC(=O)C1=CN=C(C(=O)N[C@@H1]2CCCN(C(=O)C34CC(C(F)F)(C3)C4)C2)C(Cl)=C1 O=C(C1=CC=C([N+1](=O)[O-1])[NH1]1)N2CC[C@H1]3CN(C(=O)C4(F)CC=CC4)CC[C@@H1]3C2 O=C(CCOC1CC1)N2CCCC[C@H1]2CNC(=O)C3(C4=CC=NC=C4)CCC3 CC[C@H1](O)C(F)(F)C(=O)N[C@]12C[C@H1]1CN(C(=O)C=3C=C4N(C=3)CCC4)C2 CC[C@H1](C)C(=O)N1CSC[C@H1]1C(=O)NC(C)(C)[C@H1](C)NC(=O)C=2C=COC=2 COC1=CC=NC(CN2CC[C@H1]3CN(C4=CC(OC)=NC=C4F)C[C@H1]3C2)=C1 CC(C)N1N=CC(C(=O)N2CCC([C@H1](C)NC(=O)[C@@H1](C)N3C=CN=N3)CC2)=C1Cl CC1=NC=NC2=C1C[C@@H1](C(=O)N(C)CC3=CC=NC=N3)CC2 CC1=CC=C(NC(=O)C(=O)N2C[C@@H1](C)[C@@H1](NC(=O)[C@H1]3CCCS(=O)(=O)N3)C2)C=C1 CC1=C[NH1]C(C(=O)N(C)CC2CCN(C(=O)C3=CC=C4N=CC=NC4=C3)CC2)=C1 O=C1CC[C@H1](C(=O)NCCC2(O)CN(C(=O)C=3N=COC=3C4CC4)C2)CCO1 COC[C@@H1](Cl)C(=O)NC[C@@]12CCCO[C@@H1]1CCN(C(=O)C(=O)C3CC3)C2 CC(C)(C)C1=N[NH1]C=C1CNC(=O)[C@H1]2CC(C)(C)OC2(C)C CC(=O)NC1(C(=O)N2C[C@@H1]3[C@@H1]4CC[C@@H1](CN4C(=O)CCC=5C=CON=5)[C@H1]3C2)CC1 COC1=CC(C(=O)NCC[C@@H1]2CN(C(=O)[C@@H1]3CC[C@H1](C)C3)CCCO2)=CC=C1C CC12CC(NC(=O)C3CC(NC(=O)[C@@H1](CO)OC)C3)(C1)C2 C=CC[C@H1](CNC(=O)[C@H1](C)CNC(=O)C1=CC=CC2=NC=CN12)CC(C)C CC(C)C1=NC(CC(=O)N2CCN(CC=3N=COC=3C4CC4)CC2)=NO1 CC=1N=C(C2CC2)OC=1C(=O)N(C)C[C@@H1](O)CNC(=O)[C@@H1](C)N3C=CC=N3 CC1=CC(C(=O)N2C[C@H1]3C[C@H1](NC(=O)CCC=4N=C[NH1]N=4)C[C@H1]2C3)=CO1 CC[C@H1](C)C=1C=C(C(=O)N2[C@H1]3CC[C@H1]2CN(C(=O)[C@H1]4CCC[C@@H1]4O)C3)ON=1 CC1=CC=C([C@@H1](CNC(=O)C2=CN=CC(F)=C2)NC(=O)[C@@H1]3C[C@H1]3CF)C=C1 C[C@H1](NC(=O)C1=CC=CS1)C(=O)N2C[C@@H1]3C[C@@H1](NC(=O)C4CC5(CC5)C4)[C@H1]2C3 CC(C)(C)C(=O)NC[C@@H1](CC(F)(F)F)NC(=O)C1=CC=CC(C2SCCS2)=C1 C[C@H1](CC(F)(F)F)N[C@H1]1CCCO[C@H1]1CC(=O)OC(C)(C)C O=C(C1=CN=N[NH1]1)N2CCC3(C2)CN(C(=O)[C@@H1]4CCCN4CC=5C=CSC=5)C3 C[C@H1](NC(=O)C(C)(C)C)C(=O)NC1[C@H1]2C[C@H1]1CN(C(=O)C3CC4(CCOC4)C3)C2 COCC(=O)N1CC(C2CCN(C(=O)CSC3=CC=C(C(C)=O)C=C3OC)CC2)C1 C#CC[C@@]1(C(=O)N2CCCC[C@H1]2CCCO)CCN(C(=O)C3=CCCOC3)C1 C=CCC1(C(=O)N2C[C@@H1]3CCC[C@H1](N(C)C(=O)CC4=CC(C)=NN4C)[C@H1]3C2)CC1 CCC1(C#CC(=O)NC[C@@]2(C)CN(C(=O)CC[C@@H1]3CCN(C)C3)CCO2)COC1 C=C1CCCN(C(=O)CO[C@H1]2C[C@@H1](NC(=O)C=3SC=CC=3C#N)C2)C1 O=C(NCC12CCC(CC1)CN2C(=O)CO)C3=CC=CN4N=CC=C34 C=CCN1C=C(CN2CCO[C@H1]([C@H1](C)NC3=NC=CC=N3)C2)N=N1 CCOC(=O)[C@H1](CO)NC(=O)[C@@H1](C(C)C)[C@@H1](C)NC(=O)C1=NC(C)=CC=C1C CC=1OC=CC=1C(=O)N2CC[C@H1]3[C@@H1](C2)NC(=O)CN3C(=O)CCC=4C=CN(C)N=4 CCCC[C@@H1](CC)CC(=O)N(C)C1CN(C(=O)C(C)(C)C2=CCS(=O)(=O)CC2)C1 CCC(CC)N(C)C(=O)[C@@H1]1C[C@H1](NC(=O)C[C@@H1](O)CC)C12CCC2 CCC1=CC=C(OCC(=O)N[C@@H1]2C[C@@H1](NC(=O)C3=CC=NC=C3O)C[C@H1]2O)C=C1 COC(=O)[C@H1](C)NC(=O)[C@H1](C1=NC(C)=C(C)O1)N2CCN(C3=NC=CN=N3)CC2 CNS(=O)(=O)CC(=O)NC[C@@H1](NC(=O)C[C@@H1]1CC=CCN1C)C2=CC=CC(C)=C2 C=C=C(C)CC(=O)NC1=CC=C(NC(=O)CCOC2=CC=CC(F)=C2)C=C1C O=C([C@@H1]1CCCS1(=O)=O)N2CCN(C(=O)[C@@]34CC[C@@H1](C[C@@H1]3F)C4)C5(CCC5)C2 O=C1CC[C@@H1](C(=O)NC[C@@H1]2CC3(CC3)CN2C(=O)C4=CC(C(F)(F)F)=NO4)N1 CCC[C@H1]1CN(C(=O)C=2OC=C(C)C=2C)CCN1C(=O)CSC3=NN=NN3C C#CCCCCC(=O)N[C@@H1]1C[C@H1]2C[C@H1]1CN2C(=O)C3=CSC(C4CCCCC4)=N3 CC[C@@H1](C)N(CCO)C(=O)N[C@H1]1COCCN(C(=O)OC(C)(C)C)C1 CC[C@@]1(C(=O)N[C@H1]2CC23CCC3)CCN(C(=O)C=CC4=CN(C)C=N4)C1 C[C@H1](C#N)CCC(=O)N1[C@H1]2CC[C@H1]1CN(C(=O)CN3C(=O)CC(C)(C)C3=O)CC2 CC=1N=C(C)N(CCNC(=O)[C@@H1](CN(C)C)NC(=O)C2=NOC=C2C)N=1 CC1=NC2=CC(F)=CC=C2C=C1C(=O)N3CC[C@@H1](Cl)C3 CCC[C@H1](OC)C(=O)N[C@H1]1CCN(C(=O)C=2C=C(CC)N(CCO)N=2)C1(C)C O=C(CCCC(F)F)NC[C@@]1(O)CCN(C(=O)C2=CC=C3C(=C2)NC(=O)CO3)C1 CC1=NC(C)=C(C(=O)N2C[C@@H1]3C[C@]3(C(=O)NC4=NC(Cl)=CC=C4F)C2)O1 CN1N=NC2=C1[C@H1](C(=O)N[C@H1]3CCCCN(C(=O)C[C@H1]4CC[C@H1](O)C4)C3)CCC2 CCC(F)(F)CC(=O)N1CCC[C@](CO)(NC(=O)CC2=CC=CC(C)=C2Cl)C1 CC1=CN=C(Br)C=C1NC(=O)NCCOC2=CC=CC=C2OC(C)C CN1CCC=C(CNC(=O)[C@H1]2CCC[C@@H1](NC(=O)C3(O)CCCCC3)C2)C1 C=C[C@@H1](O)C(=O)N1CC[C@H1]1C(=O)N2C[C@H1]3COC[C@@H1](C3)C2 C=C=CCC(=O)NCC[C@@]1COCCN1C(=O)[C@H1]2CC23CC(O)C3 C1O[C@@H1](C(=O)NCCNC(=O)C=CC(F)=C(C1CC)CCC)C2=CC=C(Cl)C=C2 CCC[C@@H1](OC)C(=O)NC[C@H1](C)N(C)C(=O)C1=CC=C(OC(C)C)C(N)=C1 C=CC/C=C/CCC(=O)N1C[C@H1](C(=O)N(C)[C@H1]2CCC[C@@H1]2C)[C@@H1](C(C)C)C1 CC(C)C1=NO[C@](C)(C(=O)N2CC(CN(C)C(=O)CC3CCOCC3)C2)C1 CC=1N=C[NH1]C=1CC(=O)N2CCC[C@@H1]3CCN(C(=O)COC4CC=CC4)C[C@@H1]32 CCN1CCC[C@H1]1CC(=O)N[C@@H1](CO)CNC(=O)C=2C=C(C)N(C=3C=CON=3)N=2 CCCC(CCC)NC(=O)[C@H1]1CCN(C(=O)C2=NC=C(N)C=C2C)[C@H1]1CC C[C@@H1]1C[C@H1]1CCC(=O)N2CCN(C(=O)CN3C=NC(Br)=C3)CC4(CC4)C2 CCC1(C(=O)N2CCC[C@H1](C(=O)N3CCC[C@@H1]([C@@H1]4CCCNC4)C3)CC2)CCC1 CC1(N2CCN(C(=O)C3CCC(NC(=O)COC4CC4)CC3)CC2)CCC1 CCC1=CC=C(OCC(=O)NCCCCN(C)C(=O)C#C[C@@H1]2CCOC2)C=C1 CC(C)(CC(=O)N[C@H1]1[C@@H1]2CC[C@@H1](C2)[C@H1]1C(=O)NCCC3CCOCC3)C4CC4 O=C(NC[C@@H1]1CC[C@H1]1NC(=O)[C@H1]2CCCCC23CCC3)C4=NC=CC=C4O CSC1(C(=O)N2CC3(CN(C(=O)C4=CC5=CC=CN=C5S4)C[C@@H1]3CO)C2)CC1 C[C@H1](O)CC(=O)N1C[C@@H1]2C[C@H1]1[C@@H1]2NC(=O)C3=CC=CC4=C3NC(=O)CC4 CC1=NC=NC(O)=C1C(=O)N[C@H1]2C[C@H1](NC(=O)[C@@H1]3C[C@H1]4C[C@H1]3[C@H1]5[C@H1]4C5(F)F)C2 O=C(NCCC1=CCN(C(=O)C2=CC=C(Cl)N=C2O)CC1)[C@@H1]3CC[C@@H1](F)C3 NC(=O)[C@H1](O)CNC(=O)[C@H1](CC1=CC=C(Cl)C=C1Cl)NC(=O)[C@@H1]2CCCS2 COC1=CC=C2OC([C@H1](C)NC(=O)CN3C=C(Br)C(O)=NC3=O)=C(C)C2=C1 COC1=CC=CC(CCNC(=O)[C@]2(C)CCCN2C(=O)COC3CCCCC3)=C1 CC1=CC([N+1](=O)[O-1])=CC(Cl)=C1NC(=O)C2=CN=C3C=CC(Cl)=CN23 CCO[C@@H1](C)CCC(=O)NC[C@@H1](C)NC(=O)C1=CC=C(C(=O)C(F)(F)F)S1 C[C@@H1]1CC[C@H1](C(=O)NC[C@@H1]2C[C@H1]3CC[C@H1]2N(C(=O)C4=CSN=N4)C3)C1 CC(C)(C)CCC(=O)NC[C@@H1](O)C1CCN(C(=O)C2CC(CC3CC3)C2)CC1 CCCC(=O)N1CCC([C@H1]2C[C@H1](NC(=O)[C@H1]3C[C@@]4(CC4(F)F)C3)CCO2)CC1 C[C@@H1](CC(=O)NC[C@@H1](O)CNC(=O)[C@H1]1COC(=O)O1)N2C=CC=N2 CC1(NC(=O)C=2N=C3N=CC=CN3N=2)CC(NC(=O)C4=CN(CCCF)N=N4)C1 CCCC[C@H1](O)CNC(=O)C=1C=NN(CCNC(=O)[C@@H1](C)N=[N+1]=[N-1])C=1 C#CC[C@H1](CC(F)F)C(=O)N1CC[C@@](CF)(C(=O)N2C[C@H1](N(C)C)C(C)(C)C2)C1 COC=1C=C(C(=O)NC[C@@H1](C)CNC(=O)C2=CC(C)=NC3=CC(C)=NN23)[NH1]N=1 CC(C)(C)OC(=O)N[C@@H1]1[C@H1](C(=O)N[C@H1]2C3=CC=CC(Br)=C3CC2(C)C)C1(C)C CN1C=CN=C1N2CCN(C(=O)[C@]3(C)CCCCC3(F)F)CC2 CC=1N=NSC=1C(=O)N[C@@H1](CNC(=O)C2=CN=C3C(=C2)OCC(=O)N3)C4CC4 COC1CCC(CC(=O)NCCCCC2CN(C(=O)C=3C=NN(C)C=3Cl)C2)CC1 CN(C)C(=O)[C@@H1]1CCC[C@@H1](NC(=O)C(=O)NCC2=NC=CC=C2Br)C1 O=C(NC1=CC=C2C=C(Cl)C=NC2=N1)[C@H1]3CCOC4=C(F)C=CC=C43 CC(=O)NC1=CC=C(C(=O)N[C@H1]2CC23CCC(NC(=O)[C@@H1](C)C4CC4)CC3)S1 C#CC1(OCC(=O)NC[C@@H1]2CCCCN2C(=O)C3=CC=C(CO)O3)COC1 C[C@@H1]1CN(C(=O)C[C@H1]2CCC3(CC3)CO2)C[C@H1]1NC(=O)C4=CN=C5C=CSC5=C4 C[C@@H1]1C[C@H1](CNC(=O)[C@@H1]2CCCC[C@@H1]2O)CN1C(=O)C3=CC=CC4=CN=NN34 CSC1=CC=C(O[C@H1](C)C(=O)N2CCC[C@@H1]3CN(C(=O)COCCF)C[C@@H1]32)C=C1 C=C1CC(C(=O)N[C@@H1](CC)CNC(=O)[C@H1](O)CCSC)C1 CN1CC2(CC2)C[C@H1]1C(=O)N3CCC[C@@](O)(CNC(=O)C4(CCF)CCC4)C3 CS[C@H1](C)C(=O)N[C@H1]1C[C@@H1]2C[C@H1]1N(C(=O)C3=CC=C(P(C)(C)=O)N=C3)C2 CCOCC(=O)N[C@H1]1CCCC12CN(C(=O)[C@@H1]3CC[C@H1]4C[C@@H1]3C4(C)C)C2 CC1=CC=CC2C(=O)C(C(=O)N3[C@H1]4CC[C@@H1]3C[C@H1]4NC(=O)[C@H1](C)N(C)C)=CN=C12 CCOC1(CC(=O)N[C@H1]2CN(C(=O)[C@@]3(O)CC3(C)C)CCC24CCC4)CCC1 CC(=O)NC1=CC=CC(CNC(=O)[C@H1]2CN(CC=3C(C)=NOC=3C)CC[C@H1]2O)=C1 CCN(CC)CC(=O)N(C)CCCCCNC(=O)[C@H1]1C[C@@H1]2C[C@H1](C1)C[C@H1]2O CC(C)C[C@H1](C)C(=O)N1CCC[C@@H1](NC(=O)C2([C@@H1]3CCCCO3)CC2)C1 C#CCC1(C(=O)NCC[C@@]23CC[C@H1]2CN(C(=O)CC(=O)N(C)C)C3)CC1 COC1=CN=C(C(=O)N2CC[C@@H1](NC(=O)[C@H1](F)C(F)(F)F)C[C@@H1](O)C2)N=C1 O=C(N[C@@H1]1COC[C@H1]1CNC(=O)C=2N=COC=2C3CC3)C=4C=NN5C=4NCCC5 CSC(SC)C(=O)N1C[C@H1](C(=O)N2CC3(CN(C)C3)C2)CC(C)(C)C1 CC=1N=COC=1C(=O)N2CCC(O)(CNC(=O)CS(=O)(=O)CCO)CC2 CC(C)C=1N=C(NC(=O)C2=CSC(C(=O)NC3=C(Cl)C(C(C)C)=NN3C)=N2)OC=1C CC/C=C/CC(=O)N[C@@H1]1CN(C(=O)CCC2=CC(F)=CC(F)=C2)CC1(C)C CC1=NC=C(CCC(=O)N(C)C2CCN(C(=O)C3=CC=C(C)O3)CC2)O1 O=C(NC[C@@H1]1CCCCCN1C(=O)[C@@H1]2C3C[C@@H1]4C2[C@@H1]4C3)[C@@H1]5C[C@@H1]5C(F)F O=C(N[C@@H1]1CN(C(=O)C2=CC=C(OC(F)F)C=C2Cl)[C@@]3(CCOC3)C1)C4CCC4 CC1(CNC(=O)CCC(=O)C2=CC=CS2)CCN(C(=O)CC=3C=N[NH1]C=3)CC1 CCC1=NOC(C)=C1C(=O)N[C@@H1]2CCCCC[C@H1]2NC(=O)C(C)(C)CCC#N COCCCOCC(=O)N1CCC[C@](CO)(NC(=O)C=C2CCC2)C1 C#C[C@@H1](CC)NC(=O)[C@@H1]1CN(C(=O)CCC2CC2)CC1(F)F C=CCOC(=O)NCC(=O)N[C@H1](CC(=C)Cl)C(=O)NCCCCCC C[C@H1](CNC(=O)[C@@H1]([C@@H1](C)O)N(C)C)N(C)C(=O)CSC1=NN=CN1C CCCCOC[C@H1](O)CN1C[C@H1]2CCN(C(=O)CCC3=NN=C(C)N3C)C[C@H1]2C1 CN(CCC#N)C(=O)C(=O)NC1=CC=CC2=C1CCOC2 CC1=CC(C(=O)N[C@@H1]2C[C@@H1]3CC[C@H1](C2)N3C(=O)C(C)(C)CF)=CC(F)=C1C O=C(COC1CCOCC1)N[C@@]2(C(=O)N[C@H1]3CCCCC3(F)F)CCSC2 CC(C)[C@H1](NC(=O)C=1SC=CC=1C#N)C(=O)NCCCN2CCCCC2 COC[C@@](C)(O)C(=O)NC[C@@H1]1CN(C(=O)C2=CSC(NC(C)=O)=N2)C[C@@H1]1C CC(C)[C@@H1]1CN(C(=O)CC[C@@H1]2CC2(F)F)CCN1C(=O)CCCCN(C)C CN(C)C1=NC2=C(S1)CN(C(=O)/C=C/C3=CC(N)=CS3)CC2 CC[C@H1](C)CC(=O)N1C[C@@H1](OC)C[C@H1]1CNC(=O)C2=CC([N+1](=O)[O-1])=C(N)C=C2F CCCN(C(=O)C1=CC=CN1CCC)[C@H1](C)C(=O)N[C@H1](C)[C@H1](O)C(F)F C=CC[C@@H1](CNC(=O)[C@@H1](C)N1C=NC=N1)NC(=O)C2(F)CCCCC2 CN1C=CC=C(C(=O)N2CC[C@@H1](OCC(=O)NC3(C(N)=O)CCC3)C2)C1=O CC1=NOC=C1C(=O)N2CC[C@@]3(C[C@H1](NC(=O)C4=NC=C[NH1]C4=O)CO3)C2 CCCSCCC(=O)N1CC[C@@H1]1CNC(=O)CCN2CC3=CC=CC=C3C2=O C/C=C/C[C@@H1](C)C(=O)N1CC2(C(=O)NCCC3=CN=CS3)CCC1CC2 CC(C)CC(F)(F)C(=O)NC[C@H1](NC(=O)[C@@H1]1CC(F)(F)C1(C)C)C2CCCCC2 CN(C)C1CCN(CCC(=O)N2C[C@H1]3CC[C@H1]2CN(C(=O)C4(O)CC4)C3)CC1 CN1CCC[C@](C)(C(=O)N2CC[C@H1](NC(=O)[C@H1]3CCOC3(C)C)C[C@H1]2C)C1 NC1=C(F)C=CC(Cl)=C1C(=O)N[C@@H1]2CC23CC(NC(=O)CN4CCS(=O)CC4)C3 O=C1N[C@@H1](C(=O)N2CCC[C@@H1]2CNC(=O)C3=CC=C(N4C=CN=C4)N=C3)CCO1 C[C@H1](CNC(=O)C1=CC=C(Br)C(F)=C1)CN(C)C(=O)C=CC=2C=N[NH1]C=2 NC(=O)C1=CN=CC(NCC2CCCCCC2)=N1 CN1C=C(Br)C(C(=O)N[C@@H1]2COCC[C@@H1]2NC(=O)[C@@H1]3CCC(C)(C)O3)=N1 CCS[C@H1](C)C(=O)N(C)[C@@H1](C)CCNC(=O)CC1(CS(C)(=O)=O)CC1 CCO[C@H1](CC)C(=O)N[C@H1](C)CCN(C)C(=O)C1=CSC(N=S(C)(C)=O)=N1 CCN(CCCNC(=O)CCC1=CC=CS1)[C@@H1](C)C(=O)N[C@H1](C)C2=CC=CC=C2 O=C(CC1=CC=C(Br)C(Cl)=C1F)NCC[C@@H1]2CC[C@H1]3C[C@H1]23 CC1(C(=O)NC2C[C@@H1]3CC[C@H1](C2)C3NC(=O)C4=CC(=O)C(Br)=C[NH1]4)CC1 CNC1=CN=NC=C1C(=O)N2CC=C(C(=O)NCCF)C2 CC(=O)NC1(CC(=O)N2CC[C@]3(C[C@@H1](NC(=O)C=4N=NN5C=4CCC5)CO3)C2)CC1 COC1=CN=CN=C1C(=O)N2[C@H1]3CC[C@@H1](C(=O)N(C)CCCCCO)[C@H1]2CC3 CCCC1(C(=O)N(C)CC2=CC=CC=C2CNC(=O)C3CC(CCF)C3)CCC1 CNC1=CC=C(C(=O)N[C@@H1]2CN(C(=O)CCCNC(=O)C3CC3)C[C@H1]2O)N=C1 C[C@@H1]1C[C@H1](N[C@@H1]2CCCC3=CC=C(Br)C=C3C2)C4=CC=C(Br)C=C41 C=C[C@H1]1CCCN1[C@@H1](C(=O)NCC2=CC=CS2)C3=CSC(Cl)=C3 CC1(N2N=NN=C2[C@H1](N[C@@H1]3CCSC3)C4=CC=C(C5=CC=CC=C5)S4)CC1 CC1=CC=CC(CNC(=O)OC(C)(C)C)=C1NC(=O)C=2SC3=NC=CN=C3C=2N C[C@@H1](CCC1CCOCC1)NC(=O)CC2=CC=CC(C(=O)O)=C2 CC=C[C@H1](O)C(=O)N[C@@H1](C(=O)NC1CC(CCF)C1)C(C)C C=C1COCCN(C(=O)NC2C[C@@H1]3CC[C@H1](C2)N3S(C)(=O)=O)C1 O=C(N[C@H1]1CCCC12CCC2)[C@@H1]3CCCN3CC4=CN([C@@H1]5C6C[C@@H1]7C5[C@@H1]7C6)N=N4 CC[C@H1](C)[C@@H1](C)CNC(=O)CCCCCNC(=O)C(C)(C)CNC(C)=O CC1=CC(CC(=O)N(C)CCCNC(=O)C2=C[NH1]C(C)=C(Cl)C2=O)=CS1 CCC[C@H1](OCC)C(=O)NC[C@@H1]1CCN(C(=O)C2=CN=C(O)N2C)C[C@@H1]1C CC1(C)[C@H1](NC(=O)CC(C2CC2)C3CC3)CCN1C(=O)[C@H1](F)CC4CCOCC4 COC(=O)[C@@H1](NC1=NC=C(C(F)F)C=N1)C2=CC=C(C)C=C2C CO[C@H1](CCNC(=O)CC1=CSC2=CC=CC(F)=C12)CNC(=O)OC(C)(C)C C[C@H1](C[C@H1](O)CNC)NCC1=CC=C(F)C(F)=C1F CCCC=CC(=O)N(CCCC)CC(=O)NCC1=CC(C)=NC(C)=C1 CCCN1N=C(C)C=C1C(=O)N(C)C2=NC(C(=O)OC)=C(C)S2 CS(=O)(=O)C1=CC=NC(NC[C@H1]2CCC[C@@H1]2NC(=O)C3=CC=C(F)O3)=N1 CCC1(NC(=O)C2=C(C)OCCS2)CCN(C(=O)C3=CC=CC(N)=C3O)CC1 CC=1SN=NC=1C(=O)N2CCC3(C2)CN(C(=O)C4=C[NH1]C=C4C5CC5)C3 COCC=CC(=O)N[C@@H1](C)[C@H1]1CN(C(=O)CC2(C#N)CCCCC2)CCO1 CCC(=O)NC[C@@H1]1CC(C(=O)N[C@@H1]2COC3(CCC3)C2)=NO1 COC=1C=C(C=CC(=O)N[C@H1]2CN(C(=O)C[C@H1](O)C(C)C)CC23CC3)SN=1 CC1=CC(Cl)=C(C(=O)NC[C@@]2(O)CCCN(C(=O)[C@@H1]3C(F)(F)C34CC4)C2)C=N1 CCCC[C@H1](CC)CC(=O)N(C)CC1(O)CN(C(=O)C2CCN(C)CC2)C1 CC(=CC1=CC=CO1)C(=O)N[C@@H1]2C[C@H1](C)N(C(=O)CCC3=CC=C(N)C=N3)C2 NC(=O)C[C@H1](O)C(=O)N1CCC(OC2CN(C(=O)C3=N[NH1]C=C3Cl)C2)CC1 C=C(Cl)C(C)(C)C(=O)N1CCC[C@@]2(CNC(=O)CC3=CC=CC=C3)C[C@H1]12 CCCC(=O)NCC(=O)N1CCC(CN(C)C(=O)[C@H1]2CC(=O)N(C)C2)CC1 O=C(NCCCO)[C@H1]1COCCN1CC2=CC=C(C3=CC=C(O)C=C3)C=C2 C[C@@H1](CCNC(=O)[C@H1]1CC[C@@]2(C1)CC2(F)F)N(C)C(=O)C3=CN(C)C(O)=N3 CN(C)C(=O)C=CC(=O)N[C@H1](CO)CNC(=O)[C@H1]1C[C@](O)(C2=CC=CN=C2)C1 C=C[C@@]1(C(=O)NCC2(C(C)C)CCCC2)CCN(C(=O)C3=CN=CC(CO)=C3)C1 C=CCC1(CC(=O)NCC2(O)CN(C(=O)[C@H1]3CCCS3(=O)=O)C2)CCCC1 COC1=CC=CC(CCOC(=O)[C@H1]2CC(C)(C)CO2)=C1 C=C[C@@H1]1C[C@H1]1C(=O)N2CC[C@](O)(CCNC(=O)CC3=C(F)C=NC=C3Cl)C2 O=C(NC1=NC=C(F)C=C1Cl)C2=NO[C@]3(CCN(C4=NC=NN5C=CC=C45)C3)C2 CCCNC(=O)CCC(=O)N1C[C@@H1]2C[C@H1]1[C@@H1]2NC(=O)C3=COCCO3 CC=1SC=CC=1C(=O)N2CC3(C2)CN(C4=NC(Cl)=NC5=CC=C(Cl)N=C45)C3 N#CC1(NC(=O)[C@@H1]2[C@H1]3CN(C(=O)[C@H1]4CCCN4C5CCCCC5)C[C@H1]32)CCCC1 COC(=O)CONC(=O)[C@@]1(NC(=O)C(C2CC2)C3CC3)CCC[C@H1]1C CC[C@@]1(CO)CCCN1C(=O)N[C@@H1]2CC23CC(O)C3 C[C@H1](CCCNC(=O)CSC1=N[NH1]C(O)=N1)NC(=O)[C@H1]2CCC3=C(C=NN3C)C2 CCN1C=NN=C1[C@@H1]2C[C@H1]2C(=O)NC34CC(NC(=O)COC5CC(F)(F)C5)(C3)C4 CC1=NNC(=O)[C@H1]1CCC(=O)N[C@@H1](C)CCCNC(=O)C2=CC3=CC=CN=C3[NH1]2 CC1=CC=C(CN2CCN(C(=O)C=3N=COC=3C)C[C@@H1]2CC4=CC=CC=C4)C=N1 COC(=O)CCCNC(=O)C1=NOC2=C1CN(C(=O)CCC3CC3)CC2 O=C(NC1CCC1)[C@H1](C2=CC3=NC=CC=C3O2)N4CCN(C(=O)C5CCC5)CC4 CCO[C@@]1(C(=O)N2CCC3(CC2)CC(NC(=O)[C@H1](O)C4CC4)C3)CCOC1 O=C(N[C@@H1](CO)CC1CCC1)C2=CC[C@@H1](NC(=O)[C@H1]3CN4CC[C@H1]3C4)C2 COC[C@@H1](O)CCN[C@@H1](C=1C=NN(C(F)F)C=1)C2=NN=NN2C3CC(F)(F)C3 CCC[C@H1](CC)C(=O)NCCC1CN(C(=O)CC2CCC2)C1 CC=1SC(=O)N(CCC(=O)N[C@]23C[C@H1]2[C@@H1]4CC[C@H1](C3)N4C(=O)C(C)(C)C)C=1C C[C@@H1](CN1CCN(C(=O)[C@@H1](O)CC(F)F)CC1)NC(=O)CC2(N(C)C)COC2 O=C(C=C1CCC1)N[C@H1](CC2CCCC2)C(=O)N3CCSC4(CCC4)C3 C[C@@H1](OC1=CC=C(O)C=C1)C(=O)N[C@H1]2C[C@H1](CNC(=O)[C@@H1]3CC[C@H1]4CC[C@H1]3O4)C2 COC1=CC=C(C(F)(F)C(=O)NCCCNC(=O)[C@@]2(C)CCOC2)C=N1 CC=1C=C(C(=O)N2CC[C@@H1](F)[C@H1](NC(=O)C3=C(Cl)C=CC(C)=C3N)C2)ON=1 CN(C(=O)C=1C=C(C=2C=NN(C)C=2)ON=1)C3CN(C(=O)C4=CC=CC(Cl)=C4Cl)C3 COC1=C(C(=O)NC[C@@H1]2C[C@H1]2CNC(=O)C3=CC=C4C(=C3)[C@H1](C)CN4)C=NN1C C[C@H1]1CN(C(=O)C2(F)CCCCC2)C[C@@H1](C)N(C(=O)[C@@H1]3CCOC4(CCC4)C3)C1 C#CCC(CC#C)C(=O)N1CCN(C(=O)C2=NSC3=CC=CC=C23)[C@H1](C)[C@H1]1C C/C=C/C[C@@H1](C)C(=O)N1CCN(C(=O)[C@H1]2CCO2)C3(CCC3)C1 CO[C@@H1]1CN(C(=O)[C@H1](C)NC(C)=O)C[C@@H1]1NC(=O)CCSC2=NN=NN2C CC1=CC=C(F)C=C1C2=CN(CCCCNC(=O)[C@H1]3CCCN(C)C3)N=N2 CC1=CC=C([C@@H1](C)C(=O)N[C@H1]2C[C@H1](CC(=O)N[C@@H1]3COC[C@H1]3O)C2)O1 CC1(C)CC[C@@H1]1CC(=O)N(CCO)[C@@H1]2CCCN(C(=O)C3=CC=CC=[N+1]3[O-1])C2 CC1=CC(C)=C(C(=O)N2CC[C@@H1](NC(=O)C(C)(C)CC(F)F)C[C@H1]2CO)C(N)=C1 COC1=CC=C(CCNC(=O)[C@H1]2CN(C(=O)C[C@@H1]3COCCO3)CCS2)C=C1 CC1=CC(C(=O)N2CCC[C@](O)(CNC(=O)CN3CCOCC3)CC2)=NC=C1F N=C1[NH1]N=C(CCC(=O)NC2(C3CN(C(=O)[C@H1]4CN5CCC4CC5)C3)CC2)S1 O=C(NCC1=CC=C(Cl)C=C1)C(=O)N2CC[C@H1]3[C@H1](CCN3CC4=CC=CC=C4)C2 CN(C(=O)CC[C@H1]1CCCCO1)C2CC(C(=O)N3CC4CCC(CC4)C3)C2 CC(=CC(=O)NC(C)(C)[C@H1]1CCN(C(=O)C=2[NH1]C=CC=2C)C1)C3=CC=CC=C3C CC(C)CC1=CC=C2C=C(C(=O)N3C[C@@H1](O)[C@H1](NC(=O)/C(Cl)=C/Cl)C3)[NH1]C2=C1 CCCCCCN1N=NN=C1[C@H1](NCC[C@@H1](O)C2=CC=CC=C2)C3=CC=NS3 CC=1C=NN([C@H1](C)C(=O)N2CC[C@H1](NC(=O)CCC(C)(C)C)[C@@H1](C)C2)C=1 CC[C@H1](C)[C@H1](NC(C)=O)C(=O)N(C)[C@@H1](C)CNC(=O)C=1SC=C(C)C=1C CCC1=CSC=C1C(=O)N2CC[C@@](CF)(C(=O)N3CCC34CC(CO)C4)C2 CCCCCOCC(=O)NCC12CC(CN1C(=O)[C@H1](C)N3C=CC=N3)C2 CCC(CC)[C@H1](C)C(=O)N1C[C@@H1](O)[C@H1](CNC(=O)C2=CC=C3[NH1]N=C(O)C3=C2)C1 CC1=CC=CC=C1C=2N=C(CC3=CC=NC(Cl)=C3F)N(C[C@@H1]4C[C@H1]4C)N=2 O=C1CC(C(=O)N2CC3(CC3)C[C@H1]2CNC(=O)C4=CC(F)=CC=C4Cl)C1 CC(C)CC(F)(F)C(=O)N[C@@H1]1CN(C(=O)[C@H1]2C(F)(F)C23CCC3)C[C@@H1]1F CC(C)(C)OC(=O)N[C@](C)(C(=O)NCC[C@H1]1C[C@H1](NC(=O)C2=CCOC2)C1)C3CC3 CC1=CC=CN=C1C(=O)NC[C@]2(CN=C3[NH1]C=NC(Cl)=C3CO)CC24CCC4 C[C@](CNC(=O)C1(F)CC=CC1)(NC(=O)[C@@H1]2[C@H1]3CCCCC[C@H1]32)C4CCC4 CC(C)(C)[C@@H1](C(=O)N[C@H1]1CCCN(C(=O)C2=CC(F)=N[NH1]2)CC1)C3CCCCC3 COCC(C)(C)CN(C)C(=O)C[C@@H1]1CN(C(=O)CC2(NC(C)=O)CC2)CC13CC3 CCC(CC)N(C)[C@H1](C(=O)NC1COC1)C2=CC(OC)=C(Cl)C=C2Cl O=C1CCCC[C@H1](C(=O)N2C[C@@H1]3C[C@H1]2CN3C(=O)[C@H1]4C[C@H1](C5=CC=CC=C5)O4)C1 C/C=C/C[C@H1](NC(=O)[C@H1](C)N1C=CC=N1)C(=O)N2CC(O)(CN(C)C)C2 O=C(C1=CC=C(O)C(F)=C1F)N2CC3(C[C@@H1](NC(=O)[C@@]4(CF)CC4(F)F)CO3)C2 CC1=NO[C@@H1](CC(=O)NC2CCC(NC(=O)[C@H1]3COC4=CC=CC=C4O3)CC2)C1 CC1=CC=C(CNC(=O)[C@@H1]2CCN2C(=O)[C@H1]3CCCN3C(=O)OC(C)(C)C)C=C1 CC1=CC=CC(CC(=O)N2CC3(CCN(C(=O)[C@@H1](C)C(F)(F)C(F)F)C3)C2)=C1Cl CC(C)[C@H1](C)[C@@H1](CNC(=O)CNC=O)NC(=O)CC=1C=C[NH1]C=1 CC1=NO[C@H1](C(=O)N2C[C@H1]3[C@H1](NC(=O)C4=C(C)C=C(C)C=C4N)[C@H1]3C2)[C@H1]1C C[C@H1](NC(=O)C1=CC=C(Cl)O1)[C@H1]2CN(C(=O)CC=3C=CN(C)C=3)CCO2 CC[S@](=O)CC(=O)N[C@@H1]1CC[C@H1](O)CN(C(=O)C(CC)(CC)OC)C1 CC1(NC(=O)C2=CC=C3N=CSC3=C2)CC(NC(=O)[C@@H1](O)C4CCCC4)C1 CCC1=CC=C(OCCNC2=CC(=NC3CC(C)(C)C3)[NH1]C=N2)C=C1 COC1=CC=CC([C@H1](OC)C(=O)N[C@]2(C)C[C@@H1](NC(=O)C=3C=C(C)[NH1]C=3C)C2)=C1 FC1=CC(C2=CC=CC=C2)=CC=C1NC34CC(NCC=5N=N[NH1]N=5)(C3)C4 C[C@@H1](CN(C)C(=O)C1=CC=C2C(=C1)CCCS2)NC(=O)C(C)(C)CF CCN1CCC[C@H1]1C(=O)N2CC(N(C)C(=O)C=3C=C[NH1]C(=NC)C=3)C2 CCCC[C@@H1](C)CCC(=O)NC1(CCCNC(=O)[C@H1](F)C2CCCC2)CC1 C[C@@H1](CNC(=O)CC(C)(C)CN(C)C)NC(=O)CC1=CC=C(F)C(C2CC2)=C1 CCN(C1=CC=C(CC(=O)NC=2C=NN(CCN(C)C)C=2)C=C1)S(C)(=O)=O O=C1CC[C@H1](C(=O)N2CCC[C@@H1]2CCNC(=O)C3=CC=C4C=CC=C(Cl)C4=N3)C1 CCC=1C=C(CC(=O)N[C@H1](CNC(=O)CC2=CN=CS2)C3CCC3)N(C)N=1 CC[C@@H1](NC(=O)N[C@@H1]1CCC[C@H1](C(C)C)C1)[C@H1]2CCCO2 COCCC(C)(C)CC(=O)N1C[C@@H1]2C[C@H1](C1)N2C(=O)[C@@H1]3C[C@H1]4CC[C@H1]3C4 COC[C@@H1](CN=C1[NH1]C(=N)[NH1]C(=NCC2=CC=C(N)C=C2C)[NH1]1)N(C)C CCS(=O)(=O)NCC(=O)NC12CCOC(CNC(=O)C[C@@H1](C)C(=O)OC)(C1)C2 CC[C@@H1](CNC(=O)C1=CC=C(C(C)(C)C)C=C1)NC(=O)[C@H1](C)SC2=NN=CN2C CCCC[C@H1](CC)C(=O)N[C@H1]1CN(C(=O)C(C)(C)C2=CC=NO2)C[C@H1]1CO CCN1N=CC(Cl)=C1C(=O)NCC2(O)CN(C(=O)C=3C=CN4N=NN=C4C=3)C2 C=CCN1C=C(C(=O)N2CC[C@@H1](CNC(=O)C3=CC=NC=C3F)C(F)(F)C2)C=N1 CCC[C@@](C)(O)C(=O)NC1CC(C(=O)NCCNC(=O)C2=CC(C#N)=CC=C2C)C1 CCCOCC(=O)N1CCN(C(=O)CN2N=CC(=O)C3=CC=CC=C32)CC14CC4 CSC1=CC(C(=O)N[C@@H1](CNC(=O)CC(C)(C)O)C(C)(C)C)=CC=C1[N+1](=O)[O-1] CN(CCC(C)(C)C)C(=O)C[C@@H1]1CCCN(C(=O)CN2CCC(=O)CC2)C1 C[C@@H1]1C[C@H1](NC(=O)CC(C)(C)C(C)(F)F)CN1C(=O)C2CC3(CCCO3)C2 CC1=C(C)C[C@H1](C(=O)NC[C@H1]2CC3(CC3)CN2C(=O)[C@H1]4CNC(=O)C[C@@H1]4C)CC1 C[C@H1](CF)NC(=O)C(C)(C)C1=CCN(C(=O)C2=CC(O)=CC(F)=C2)C1 C[C@@H1](C(=O)N1CCC[C@@]12CCCN(C(=O)C3=NC=C(F)C=C3F)C2)P(C)(C)=O C#CC[C@]1(O)C[C@@H1](C(=O)N[C@@](C)(CNC(=O)[C@]23C[C@H1]2CCC3(F)F)C4CC4)C1 CC1=CC=C(C)C(C2=CC3=C(S2)CCN(C(=O)C4=NNC(=O)CC4)C3)=C1 CC1=NC2=NC=NN2C(N3CCO[C@@H1]([C@@H1](C)NC(=O)CC4=CCCCC4)C3)=C1C CN(C(=O)[C@@H1]1CCCC[C@]1(C)NC(=O)CCC2=NC(=N)[NH1][NH1]2)[C@@H1]3C[C@H1]3C4CC4 CC1=C(F)C=C(F)C=C1NC(=O)N(C)CC2(C)CCCC2 O=C(C=CI)N1C[C@H1]2C[C@@H1](C1)N(C3=NC=NC=4SC=C(Br)C3=4)C2 CC=1C=C(C(=O)N[C@H1](C(=O)N(C)OCC2=CC=CC=C2)C3=CC=CO3)SN=1 CC1=CN=C(F)C([C@H1](C)NC(=O)N2CC[C@@]3(CNC(=O)C3)C2)=C1 CCC(=O)NC[C@H1]1[C@@H1]2C[C@H1]1CN2C(=O)COC3=CC=CC(C(=O)N(C)CC)=C3 CCOC1CC(N[C@@H1](C)C2=CSN=N2)(C3=NN=NN3[C@@H1](C)CC)C1 C#CC[C@]1(C(=O)NC/C=C/CNC(=O)COC=2C=CN(C)N=2)CCOC1 CC=1N=C(CC(C)C)OC=1C(=O)N2CCOC[C@H1]2CNC(=O)CS(C)(=O)=O CCC[C@@H1](O)CC(=O)N1CC[C@](O)(CNC(=O)C23CC(C)(CCO2)C3)C1 CCCCCCCC[C@H1](F)C(=O)N1CC[C@](O)(CNC(=O)C2(C#N)CCCC2)C1 C=C(C)[C@H1](CC(=O)N1CC[C@H1](C(=O)N2CCO[C@H1]3[C@H1](O)C[C@H1]32)[C@H1]1C)OCC O=C(NC1=C(Cl)C=CN=C1C(F)(F)F)C2=CC(C3=CC=CC=C3C(F)(F)F)=NO2 C=CCC(CC=C)C(=O)N[C@@H1]1CCC[C@H1]1NC(=O)C2=CC3=CC=C(C)C=C3O2 CN(CC(=O)NC[C@@H1]1CCC(C)(C)CN1C(=O)[C@@H1]2C[C@H1]2F)CC3=CC=CC(Cl)=C3 CC1=CC=C(CC(=O)N(C)C2CN(C(=O)C[C@@]3(C)C[C@H1]3F)C2)C=C1C CC1(C)CCC(C)(C(=O)N2CC[C@@H1](NC(=O)CN3CCCCC3=O)C2)CC1 CCCC[C@H1](O)C(=O)N(C)[C@@H1]1CN(C(=O)CCCCN2CCCC2)CC13CC3 CCC=CC=CC(=O)N1[C@@H1]2CN(C(=O)C3=CC(=O)C=C(Cl)[NH1]3)C[C@@H1]2C[C@H1]1C CC1=CC(C)=C2C(=C1)N(N3CC[C@@H1](S(=O)(=O)NC4CC4)C3)CC2 O=C(NC[C@H1]1COCCN1C(=O)CSC2=CC=C(O)C=C2)C3=CN=C(C4CC4)O3 CCCC(CCC)C(=O)N1CCC[C@H1](C(=O)N[C@H1](CC)CCO)C1 COC(=O)C1=CC(C(=O)N2CC[C@](C)(CCNC(=O)[C@@H1](F)C(C)C)C2)=CS1 C[C@@H1](C(=O)NCCOCCCN(C)C(=O)C1=CC=NC2=C1CC(=O)N2)C(F)(F)F C#C[C@H1]1CN(C(=O)[C@H1]2CC3(CCC3)CN2C(=O)C4=CN=C5N4CCC5)CCN1C O=C(C1=CN=CC(Cl)=C1)N2C[C@@H1]3CCCN(C(=O)C4=CC=CN=C4O)[C@@H1]3C2 CC1=CC=CN=C1C=CC(=O)NC2(CO)CN(C(=O)[C@H1]3CC(=O)N3)C2 COCCOC1=CN=CC(C(=O)N[C@@H1]2[C@H1]3C[C@@H1]2N(C(=O)[C@H1](C)S(C)(=O)=O)CC3)=C1 CN(C(=O)[C@@H1]1CC2=NN=CN2C1)C3CC(NC(=O)CN4C=CC(=O)N(C)C4=O)C3 COCC[C@@H1](C)C(=O)N[C@@H1](C)CCN(C)C(=O)/C=C/C1=CN=CC(C(F)(F)F)=C1 CC1CC(CCNC(=O)[C@H1](C(C)C)[C@@H1](C)NC(=O)C2=CCCC2)C1 COC1=CC=C(Cl)C(CC(=O)NC2(C3=NC=CS3)CCCC2)=C1 O=C(C=1SC=CC=1Cl)N2CC[C@H1]([C@H1]3CCCN3C(=O)C4=COC=N4)C2 CCOC(=O)C(CNC(=O)[C@@H1](C1=C2C=CN=C1OC)N(C)C[C@@H1](C)C(C)C)CC2 COC1=C(Cl)N=CN=C1N[C@H1]2CC[C@@](C)(CNC(=O)C3=CC=4OC(C)=CC=4[NH1]3)C2 CC1(OCC(=O)N[C@@H1]2CC[C@H1](CO)C2)CN(C(=O)[C@H1](O)CCC(F)(F)F)C1 CCCCC[C@H1](O)C(=O)NCC1=CC=C(C(=O)N[C@H1](CC)CCCC)O1 CCNC(=O)CCC(=O)N1CC[C@](F)(CNC(=O)C2CC(N3CC(O)C3)C2)C1 NC1=CC=C(Cl)N=C1C(=O)N[C@@H1]2C[C@H1]3CC[C@H1]2N(C(=O)CCNC(=O)C=CCl)C3 C=C[C@H1]1CN(C(=O)OC(C)(C)C)CC[C@H1]1CC(=O)OC2=CC=C(C(=O)O)C(Br)=C2 C[C@H1]1C[C@H1](NC(=O)C2=CSC(C(F)(F)F)=N2)CN1C(=O)CC3CSC3 N=C(O)OCCN=C1[NH1]C(N2CC[C@@]3(C2)C[C@H1](O)C3)=NC4=CC=C(Cl)C=C14 CCN1N=C(C(=O)NC[C@H1]2CC[C@@H1](NC(=O)C3=CC(O)=NC=N3)C2)C=CC1=O O=C(NCC1=CSN=C1C(F)F)[C@H1]2CN3CCC[C@H1]2CC3 C[C@@H1](CO)C(=O)N1CC[C@H1]2CCC[C@@H1](C1)N2C(=O)[C@@H1]3COCC(C)(C)O3 CCC1=CC(C)=C(C(=O)NCC=2C=NN(C)C=2C(=O)N(CC)C3CCCC3)O1 CC(C)(C)C=1[NH1]C=NC=1C(=O)N[C@H1]2C[C@](F)(CNC(=O)C3=C[NH1]N=C3C4CC4)C2 CC1(C)CC(CC(=O)N2C[C@H1]3C[C@@H1](CN(C(=O)C4=CC(O)=CC(=O)O4)C3)C2)C1 C[C@@H1](NC(=O)C1=C[NH1]C(C(N)=O)=C1)C2CCN(C(=O)[C@@H1]3CC[C@H1](F)C3)CC2 C[C@@H1]1CN(C(=O)[C@@H1](O)CC2CCCC2)CCN1C(=O)C[C@H1]3CCC4(CCC4)O3 C[C@@]12CCCC[C@H1]1N(C(=O)C3=CC=[N+1]([O-1])C=C3)CCC2 CC(C)C(C(=O)N1CC2(CCCCN2C(=O)C3=NS[NH1]C3=O)C1=O)C(C)C CC[C@H1](CNC(=O)[C@@H1]1[C@@H1](C)[C@H1]1C)NC(=O)[C@H1](C)NC(C)=O CCC1(NC(=O)[C@H1](CSC)OC)CCN(C(=O)C2SCCN(C)C2)CC1 CC(C)[C@@H1](CO)NC(=O)CC[C@@H1]1CCCCN(C(=O)C2(CF)CCOCC2)C1 CCN(CCCNC(=O)[C@@]12CCCN(CC1)C2)C(=O)[C@@H1](O)C3=CCCCC3 C[S@@](=O)C1=CC=C(CC(=O)N2C[C@@H1]3C[C@H1]2[C@@H1]3CNC(=O)C=4C=C(CO)ON=4)C=C1 CC=1C=C(C(F)(F)F)N2N=CC(C(=O)OCC3=CC=NC(N4CCCC4)=C3)=C2N=1 CCC1=CC=CC(C(=O)NC[C@@H1]2C[C@@]3(CCN(C(=O)CC[S@](C)=O)C3)CO2)=C1C CC(C)(C)[C@@H1](CCO)NC(=O)[C@@H1]1CC2(CCN1C(=O)[C@@H1]3CSCC(=O)N3)CC2 C[C@H1](NC(=O)[C@H1](O)C1CCCCC1)C2=NOC=C2C(=O)N[C@H1]3CCOC(C)(C)C3 CC1=CC[C@H1](NC(=O)C[C@H1]2CCN2C(=O)C3=CCCC[C@H1]3C)CC1 CC1=CC(C(=O)N2CC[C@@H1]([C@@H1](C)NC(=O)C=3C(C)=COC=3C)C2)=C(C)O1 CC(C)/C=C/C(=O)NC[C@@]12CCC[C@@H1](CN1C(=O)[C@@H1]3COCCN3C)C2 CC1=CC2=C(C=C1C)O[C@H1](C(=O)NC[C@@H1]3CCCN(C(=O)[C@H1]4CCO[C@@H1]4C)C3)C2 CC[C@@H1](C)[C@H1](OC)C(=O)NCCN(CC)C(=O)C=C(C)C1=CC=C(OC)C=C1 CO[C@H1]1C[C@@H1](C(=O)N2CCCO[C@H1](CNC(=O)[C@H1]3C[C@H1]3C)C2)C1 CO[C@H1](C)CC=1N=C(C2=NC(C)=NN2C)N(C3=CC=NN=C3)N=1 CC[C@@H1](OC1=CC=CC=C1)C(=O)N(CCNC(=O)OC(C)(C)C)CC(OC)OC C#CC1=CC=C(Br)C(C(=O)N2C[C@@H1](C)[C@H1](CNC(=O)C[C@H1]3CC34CC4)C2)=C1 C#C[C@]1(NC(=O)C(=O)N=C2C=CC(CC(F)(F)F)=N[NH1]2)CCCC(C)(C)C1 C[C@@H1](CNC1=CC(N(C)CC2=CSC(Br)=C2)=NC=N1)C3CCC(F)(F)CC3 CC1=CC=CC=C1C(=O)N(C)[C@H1]2CC[C@@H1](NC(=O)C[C@@H1](C)N3C=CC=N3)C2 CSCC(=O)N1CC[C@@](CF)(C(=O)N[C@H1](C)C2CSC2)C1 CC[C@](C)(Cl)CNC(=O)C[C@@H1]1C[C@@H1](O)CN1C(=O)[C@H1]2CCCCCN2C C#CCCCC(=O)N1CCC(C(C)(C)CNC(=O)C2=CC(N(C)C)=CC=C2N)CC1 C[C@]1(C(=O)N2CCC[C@@H1](NC(=O)C3CC[C@H1]4[C@H1](CC3)C4(F)F)C2)CCCO1 C=CC1(C(=O)NCC#CC(=O)N2CCN3C(=O)CC[C@@H1]3C2)CCOCC1 C=C=C[C@H1](C)C(=O)N1CCN(C(=O)C2=CC(F)=C(Cl)C=C2Cl)C[C@H1]1CCO C[C@@H1]1CCN(C(=O)C2(C(=O)NC3CC3)CCC2)CCN1C(=O)[C@H1]4C[C@@H1]4F COC1=CC=C(C(=O)NCCCN(C)C(=O)CSC2=CC=C(O)C=C2)C(OC)=N1 O=C(CCC1=CC=NC=N1)N[C@H1]2C[C@@H1](NC3=CC=C([N+1](=O)[O-1])C=C3C(F)(F)F)C2 CC(C)(O)CC(=O)N1CC[C@@H1]([C@@H1]2CCCN(C(=O)CCSC3=NC=CN3C)C2)C1 C=C[C@@]1(C(=O)NC2=CN=CC([N+1](=O)[O-1])=C2)CCN(C(=O)C3=CC(C)=NC(O)=C3)C1 CCC1=C(C(=O)N2CCC(C)(C(=O)NC[C@@H1]3CN(C)CCO3)CC2)C=NN1C CCCC1=CC=C([C@H1](C(=O)N[C@@H1](C)CC)N(C)CC=2SC=NC=2C)C=C1 CC(C)(C(=O)N1C[C@H1]2[C@H1](NC(=O)[C@H1]3CC34CCCCCC4)[C@H1]2C1)C5=CC=CN=C5 C[C@@H1]1CN(C(=O)C2=CSC3=CC=CC=C23)C[C@@H1]1NC(=O)CC=4C=N[NH1]C=4 CC1=NC=C(CCNC(=O)[C@@H1]2CNC(=O)CN2C(=O)[C@H1](C)C3=CC=CS3)O1 CCCOCCCC(=O)N(C)[C@@H1]1C[C@H1]2C[C@@H1]1N(C(=O)C3=NC=CC=C3OC)C2 CCC1=N[NH1]C=C1C(=O)N2CCCN(C(=O)C3=CC(N)=CC=C3SC)[C@H1](C)C2 COC1=CC(F)=CC(NC(=O)[C@H1]2CNC(=O)CN2C(=O)[C@@H1](CO)N(C)C)=C1 CCC1=C(C(=O)N[C@@H1](C)CN(C)C(=O)C[C@@H1](C)C(C)(C)C)C=NN1C(C)(C)C CC1(NC(=O)N=C2SC=CN2CC3=CC=CC=C3I)COC1 C=C(C)CN1N=NN=C1[C@@H1](NCC2=CC3=C(S2)CCCC3)[C@@H1]4CC4(Br)Br CC[C@H1](CC(F)F)C(=O)N[C@@H1](C)CCNC(=O)C1=CN(C2=CC=CC=C2)C=N1 C#CCN(C(=O)C1=CC=NS1)C2CCN(C(=O)C3=CN=C(C(N)=O)C=N3)CC2 CN1N=NC(CNC(=O)[C@H1](C2=CC(C3CC3)=NO2)N4CCCCC45CCC5)=N1 COC[C@@]1(C(=O)NCC23CC(NC(=O)C4=CN=C5N4CCC5)(C2)C3)C=CCC1 CCCC=CCCCCC(=O)N1CCC[C@@H1](CCNC(=O)[C@@H1]2CCC(C)(C)C2)C1 O=C(C[C@@H1]1CCCCN1C(=O)C2CC3(CC(O)C3)C2)N4C[C@@H1]5C[C@@H1]5[C@@H1]6C[C@H1]64 CC1=C(C(=O)N2CC3(CCNC(=O)C4=CN=CC=C4Cl)CC2CC3)CCS1(=O)=O C[C@@H1]1OCC[C@]1(F)C(=O)N2CCN(C(=O)CCC3=CC=NN3C)C[C@H1](O)C2 CN(C)C1(CNC(=O)C(=O)N[C@@]23CCCC[C@H1]2C3)CCC(CC1)CC CC(=O)N[C@@H1](CC(C)C)C(=O)N(C)[C@@H1]1CCCN(C(=O)C23CC(C2)C3)CC1 CCOC1=NC=CC=C1NC(=O)[C@@H1]2CCCN(C(=O)C3(C(C)C)CC(=O)C3)CC2 CC1(F)CC2(CCN(CC[C@H1]3CCOC3=O)C2)C1 CC1=C(C(=O)N2C[C@@H1](NC(=O)C=3SC=CC=3C#N)C[C@H1]2C)[NH1]C=CC1=O C=CC[C@]1(NC(=O)C2=CC=NN2C=C)CCCN(C(=O)[C@H1](C)N3CCSCC3)C1 CC(C)CN1CCC[C@@H1](C(=O)N2CCCC[C@@H1]2CCNC(=O)[C@H1]3C[C@H1]3C)C1 CN1C[C@H1](O)CC[C@H1]1C(=O)N[C@@H1](CO)C(=O)N=C2C=CN(C)[NH1]2 CCOC(CC(=O)N(C)CCOCCNC(=O)C1=CC=NS1)OCC CC[C@H1](NC(=O)[C@H1]1[C@@H1](C2CC2)CCN1C(=O)CCCNC(=O)OC)C(C)(C)O CC=1C=CN(C)C=1C(=O)NC2C[C@@H1]3CCC[C@H1](C2)N3C(=O)[C@]45C[C@H1]4CC6=C[NH1]N=C65 C[C@@H1](NC(=O)CNC(=O)CNC(=O)C1=CC=C(O)C(F)=C1)C2=NN=C(O)O2 O=C(COC1=CC=CC2=C1CNCC2)N[C@@]3(C4CC4)COC3 C#CCCCC(=O)NCCCC1(NC(=O)[C@]23C[C@@H1]2CN(C(C)=O)C3)CC1 N#CCN1C=C(NC(=O)C(N2C=C(C3=CC=CC=C3)N=N2)CC4=CC=CC=C4)C=N1 O=C(C=1N=CSC=1Br)N2CCC(F)(F)[C@@H1](NCC3=CC=NC(Br)=C3)C2 CC=1C=C(C(=O)N[C@H1]2CCCN(C(=O)C3=CC=4SC=C(C)C=4[NH1]3)C2)SN=1 C#CCN(OC)C(=O)[C@@H1]1CC(=C)CCN1C(=O)[C@@H1](C)CC(C)(C)C C=CCCCC(=O)N1[C@H1]2CC[C@H1]1CN(C(=O)C=3C=C(C4CCC4)ON=3)CC2 CCC1=CC(F)=CC=C1C(=O)N2CCCC[C@H1]2CCCNC(=O)C=3C=NSC=3C CCCC=1N=NSC=1C(=O)NC[C@@H1]2CC3(CCC3)CN2C(=O)C4=C(C)OCC4 CC1=C[NH1]C(C(=O)N2CC(O)(CNC(=O)[C@@H1]3CCCC4=NC=CC=C43)C2)=CC1=O COC(=O)[C@H1]1C[C@H1](C)N1C(=O)CCN(C(=O)C=2C=C(CO)[NH1]N=2)C(C)C CS[C@@H1](C)CCNC(=O)CC1(NC(=O)C2=CN(C)C=N2)CCC1 CCC1=CC=CC=C1[C@@H1](CNC(=O)C2=C[NH1]N=C2C)NC(=O)[C@H1](CC)N(C)C CN(C[C@@H1](O)C1CCC1)C(=O)[C@H1]2CN3CCCC[C@@H1]3CO2 C=C[C@](C)(O)C(=O)N[C@@H1]1CCCCN(C(=O)C2=CC=C(Br)N=C2O)CC1 O=C(NCC1=CN=CS1)C=2C=COC=2CNC(=O)C3CC(=C4CCC4)C3 CCN1N=C(C)C=C1C(=O)NCC2(O)CN(C(=O)C3=CC(CC(C)C)=NN3C)C2 C[C@@H1](CCNC(=O)CC1=CN=CC(F)=C1)NC(=O)C2CC(C)(C)OC(C)(C)C2 CCC1=NC(C#N)=CC(=N[C@H1](C)[C@H1]2CCCN(C(=O)C3=CN=C(O)N3C)C2)[NH1]1 O=C(CC1=CC=CC=C1I)N[C@@H1]2CCN(CC3=CC=CC(Cl)=C3F)C[C@H1]2O CO[C@@]1(C(=O)N[C@@H1](C)[C@H1]2CCCN(S(=O)(=O)[C@H1]3CCS(=O)(=O)C3)C2)CCCOC1 CCOCC(=O)NC[C@H1](COC(=O)C1CCC(C)=C(C)C1)CC=O C[C@@H1]1CN(C(=O)C2=CN=C(C(F)F)C=N2)CC[C@H1]1NC(=O)[C@@H1]3CC4CC3C4 CCC[C@](C)(CC)C(=O)N[C@@H1]1C[C@@H1]2CN(C(=O)CCOC)C[C@@H1]21 CN1C=CC=C([C@H1](C(=O)NC2COC2)N(C)CCNS(C)(=O)=O)C1=O C=C(C)CCC(=O)N1CC[C@](COC)(NC(=O)C2=COC(N(C)C)=N2)C1 O=C(CN1CCCCC1=O)NC[C@@H1](CO)NC(=O)[C@@H1]2COC[C@H1]2C(F)(F)F CCCC[C@@H1](CC)C(=O)N1CC2(CN(C(=O)C3=NN(C)C=C3[N+1](=O)[O-1])C2)C1 CCN(C[C@H1](C)NC(=O)C1=CC(Cl)=CC=C1C(F)(F)F)C(=O)C=C2CC[C@@H1](C)C2 COC1=CC=CC(/C(C)=C/C(=O)NC2=CC=CC=C2N3CCCS3(=O)=O)=C1 CC1=C(C(=O)N[C@H1]2CCC[C@@H1]2NC(=O)[C@@H1]3CC[C@H1](C(=O)OC(C)(C)C)O3)CCC1 CCC[C@@H1]1CN(C(=O)CCN(C)CCO)CCN1C(=O)[C@@H1]2CCN3C=NN=C3C2 O=C(N=S1(=O)CCC2(CC1)OCCO2)[C@H1](O)CC3=CC=CC=C3 COCCOCC=1OC=NC=1C(=O)N(C)[C@H1]2CCCN(C(=O)C3=COCC3)CC2 C[C@@H1]1OC2(CNC(=O)C(N)=O)CC1(NC(=O)C3=CC=C4N=NN(O)C4=C3)C2 CC1(C)CCN(CC(=O)N2C[C@H1]3C[C@@]3(CNC(=O)[C@H1]4OCCN5C=CN=C54)C2)C1 COC[C@@H1](C)C(=O)N1CCC(O)([C@H1](C)NC(=O)CN2C=CN=N2)CC1 CCC(C)(C)CC(=O)N[C@@H1](CC(C)(C)C)C(=O)NCC1=COC(C)=C1 N#CC1(C(=O)N2CCO[C@H1](CNC(=O)C=CC3=CC=CC=C3[N+1](=O)[O-1])C2)CCC1 COC(=O)C1=C(C(=O)N(CCNC(=O)C2=CC=C(OC)C(C)=C2)C3CC3)SC=N1 CCCCCC(=O)N1CSC[C@@H1]1C(=O)OCC(=O)OCC CC(=O)OC[C@@](C)(NCC[C@@H1]1CCS(=O)(=O)C1)C2=NN=NN2C CNC(=O)CCCCC(=O)N1CCCN(C(=O)C2(F)CCC2)C[C@@H1]1CO C=CC[C@@]1(NC(=O)[C@@H1]2CC3=CC=CC=C32)CCN(C(=O)CCCC4CC4)C1 CO[C@@H1](CNC(=O)C[C@H1](O)CN(C)C)CC(=O)NCC1CC2(CC2)C1 CCC(CC)CC(=O)N[C@H1](CC(=O)NC1=CN=C2C(=C1)CCC2)[C@@H1](C)CC CCCC1(C(=O)N[C@H1](C)CCN(C)C(=O)C[C@@H1]2CCCCC2(C)C)CC1 CO[C@@](C)(C(=O)N1C[C@@H1]2C[C@]2(CNC(=O)C3=CSC(Cl)=N3)C1)C4CCOCC4 C#CCOC1=CC=C([C@H1](NC2CSC2)C3=NN=NN3[C@@H1](C)CC)C(C)=C1C COC(=O)C1=CC(CSC[C@H1]2COCC2)=C(OC)C(OC)=C1 C=C(C)C[C@@H1](OC)C(=O)N1CCC[C@@H1](CCC(=O)NCC[C@H1]2COCCO2)C1 CCCN(C(=O)C1=CON=C1C)[C@@H1](C)C(=O)NC[C@H1](C)C(=O)OC CN1C=C(NC(=O)C(=O)C2CC2)C=C1C(=O)N3CCN(S(=O)(=O)CC(C)C)CC3 CCC[C@@H1](C(=O)NC[C@@H1]1C[C@@H1](O)CN1C(=O)C2=NN=C3C=CC=CC3=N2)N(C)C CCN(C)CC(=O)NC[C@@H1]1C[C@@H1]2CC[C@H1](C1)N2C(=O)CC=3C=C(C)SC=3C COCCCC(=O)N(CC(=O)NCC1=CC=C(C)C=C1O)C(C)C CSCC[C@@H1](O)CC(=O)N1CC[C@](CF)(NC(=O)CN2C=CN=C2C(C)C)C1 C=C[C@@H1]1COCCN1C(=O)[C@H1]2C[C@@H1](OC)CN2C(=O)[C@@H1]3[C@H1]4COC[C@H1]43 COCC12CC(NC(=O)C(=O)N(C)[C@@H1](COC(C)(C)C)C3CC3)(CO1)C2 CC(C)(C)C[C@H1]1CCN1C(=O)[C@@H1](NC(=O)CN=C2C=C[NH1]C=C2)C3CCCC3 CC[C@@H1](C#N)C(=O)N1CCC(CNC(=O)[C@H1]2CCS2(=O)=O)(OC)CC1 CS[C@H1](C(=O)N(C)C[C@H1]1CC[C@H1](CNC(=O)C23CCC(C2)C3)CC1)C(C)C CC[C@@H1](C)C=1C=C(C(=O)N2CCN(C)C[C@@H1]2CNC(=O)C3=C[NH1]N=C3C)ON=1 CN1N=C(C(=O)NC[C@H1]2CCCN2C(=O)C3=COC(Br)=N3)C=C1C4CC4 COCC1=NC(C(=O)NC[C@@H1](C)N(C)C(=O)C2=CC=C(C(C)C)S2)=CS1 CC1=CC=NN1CC(=O)N[C@H1]2CCN(C(=O)CCC3=CC=CC(Br)=C3)C2 CO[C@@H1](C)C(=O)N1CC[C@@H1](CNC(=O)C2=CC=C(OC(F)F)C=N2)C1 CN(CC(CO)(CO)NC(=O)[C@@H1]1COCCN1C=O)C(=O)C=CC2CCOCC2 COC1=CC=NC=C1C(=O)N2C[C@H1](NC(=O)C=3C(C)=NOC=3C4CC4)[C@@H1]5C[C@@H1]52 CCOC1=CC=CC=C1N2CCN(C3=CC(F)=CC=C3N4CCCC4)CC2 C#CC[C@@](C)(NC(=O)[C@H1](C)N1CCNC1=O)C(=O)N[C@H1]2CCNC(=O)CC2 CC(C)(C(=O)N([C@H1]1CC[C@@H1](F)C1)[C@@H1]2COC3(CCNCC3)C2)C4=CC=CC=N4 COC[C@@H1](C)CNC(=O)N1CCN(CC2=CC=C(C3=CSC(C)=N3)S2)CC1 CC(C)(CC1=CC=C2C(=C1)OCCO2)C3=NN=C(C4=CC5=C(C=N4)OC5=O)O3 CC[C@@H1](NC(N)=O)C(=O)N[C@H1]1CN(C(=O)CN(C)S(C)(=O)=O)C[C@@H1]1C CC[C@H1](C)NC(=NCCCC=1C=N[NH1]C=1)NC[C@H1](CO)C(F)(F)F CCC(F)(F)CCNC(=O)[C@H1](CO)NC(=O)C1=CC=C(COC)C=C1 CC1=CC=C(CC(=O)O)C=C1S(=O)(=O)NC[C@@H1]2CN(C3=CC=CC(Cl)=C3)CCO2 CCSCCC(=O)NC[C@H1]1COCC2(CCN(C(=O)[C@H1]3C[C@H1]3CN(C)C)CC2)O1 CC=CC(=O)N1CCC[C@H1](CN(C)C(=O)C2=C(Cl)C=CC(OC)=C2NC)C1 CC1=CC(C)=CC(C(=O)N(C)[C@@H1](CC(C)C)C(=O)NOC2CC2)=C1 CC1=NN=CC=C1C(=O)N2CCCCC[C@@H1]2CNC(=O)C3=CN=CC=4C=CSC3=4 C[Si](C)(C)C1=CC=C(C(=O)N2C[C@@H1](C(=O)NCCC=3C=CSC=3)C[C@@H1](F)C2)C=C1 CN(C1=NC=NC(Cl)=C1C#N)[C@@H1]2CCN(C(=O)[C@@H1]3CCCCS3(=O)=O)C2 CCN(C(=O)C(OC)OC)[C@H1](C)CNC(=O)[C@@H1]1CC(C=2C=NN(C)C=2)=NO1 COC(=O)[C@H1]1[C@@H1](N)CCCN1C(=O)C2(C3=CC=CC(F)=C3)CCOCC2 CCN(C)CCC(=O)N1C[C@@H1]2CCC[C@]2(CNC(=O)CC3=CSC(S)=N3)C1 C[C@@H1](C(=O)NCC[C@@H1]C1CN(C(=O)C2(N3N=CC(Br)=N3)CC2)CCO1)N(C)C CCO[C@@H1]1[C@@H1](C)[C@H1]1C(=O)N2CCC[C@H1](CNC(=O)C3=NN(C)C(=O)OC3(C)C)C2 COC(=O)[C@H1](CNCC1=CC=C(OC(F)F)C(Cl)=C1)C[C@H1]2CCOC2 C[C@@H1]1[C@H1](C(=O)NCCCCCNC(=O)C2=CN=C3C=CC(Cl)=CN3C2=O)[C@@H1]1C C=CCC[C@@H1](NC(=O)[C@H1]1OCCO[C@H1]1C)C(=O)NCCOC2CCCC2 CCN(C[C@@H1]1CCCN1CC)C(=O)C2=NC(=NCCC3=CC=CC=C3)[NH1]C=C2Cl CC1=CC=CC(C(=O)NC[C@@]2(C)CCN(C(=O)[C@@H1]3CCCCNC3=O)C2)=C1CO O=C(CCC1=CC=C(O)N=N1)N2C[C@@H1]3CCN(C(=O)[C@@]45C[C@@H1](O)[C@@H1]4C5)C[C@@H1]32 CO[C@]1(C)CCCN(C(=O)[C@@H1]2CCN(C(=O)C3=NC=CC=C3Cl)CCO2)C1 C[C@@H1](NC(=O)C1(C)CC(F)C1)C(=O)N2O[C@H1]3CC[C@H1]2C3 CC[C@@](C)(CCNC(=O)C[C@@H1]1CCOC2=CC=CC=C21)NC(=O)C3=CCCSC3 C[C@H1](C(=O)NCC1=CSC=N1)[C@@H1]2CCN(C(=O)[C@H1]3COC[C@H1]3C(N)=O)C2 O=C(C1SCCCS1)N2CC[C@@H1](OCCNC(=O)C34C5C6C7C5C3C7C64)C2 NC1=CN=CN=C1C(=O)N[C@@H1](C(=O)NCCC[C@@H1]2CCOC2=O)[C@@H1]3CCCO3 O=C1NCC2=CC(Br)=C(OCC[C@@H1]3CC(C4=CC=CC=C4)=NO3)C=C21 C=CCN1C=CC=C1C(=O)N[C@@]2(COC)CCN(C(=O)C[C@@H1]3CCCC(=O)N3)C2 CCCCS(=O)(=O)CC(=O)NC[C@@H1]1CN(C(=O)C=NOC)CC[C@]12CCOC2 C[C@H1]1CCN(CCCC2=CCCCC2)C[C@H1]1NC(=O)C=3C=C[NH1]N=3 CCCCNC(=O)[C@H1](C1=CC=C(C=2C=NN(C)C=2)S1)N3CC(=O)N[C@H1](C(C)C)C3 CC1=CC(C(=O)N(CCNC(=O)[C@]23CSC[C@@H1]2C3)C4CCCCCC4)=C(C)[NH1]1 CCN(CCNC(=O)CNC=O)C(=O)[C@@H1](C)N(C)CC1=CC=CC=C1 O=C(COCC1CCOCC1)NC[C@@]2(F)CCN(C(=O)CC3=CC=CS3)C2 C/C=C/[C@H1]1CN(C(=O)CCN2C=CN=N2)C[C@@H1]1C(=O)N(C)C[C@H1](O)C3CCC3 CN1CCCC[C@@H1]1C(=O)N2CC[C@]3(NC(=O)CC=4N=C[NH1]N=4)CCC[C@H1]23 CCCC1=CC(C(=O)N[C@@H1](C)/C=C/C(=O)N[C@@H1]2C[C@H1]2CCOC)=N[NH1]1 CC1=CC(C(=O)N(C)C[C@@]2(O)CCCN(C(=O)C3(C)CC(C)C3)C2)=CS1 C#CCCN(C)CC(=O)N[C@@H1]1CC[C@H1](CNC(=O)[C@](C)(O)CC)C1 CCCN(C)[C@H1](CC)N=C1[NH1]C=NC=C1F C[C@@H1]1[C@H1]2C[C@H1]([C@H1]2NC(=O)[C@@H1]3CC3(F)F)N1C(=O)CCCN4C=CC=N4 C#CC[C@H1](CC(=O)NC1=CN=CC(F)=C1)NC(=O)[C@@H1](C)[C@@H1](O)C(C)C COC[C@@H1](CF)NC(=O)[C@H1]1COC2=CC=C(Cl)C=C2C1 CC1=CN=C(F)C(C(=O)N2C[C@H1](NC(=O)C(F)(F)[C@@H1](C)O)C[C@@H1]2C)=C1 CSCCC(C)(C)C(=O)NCCC1(NC(=O)C2=CC=C(N)C3=C2CCCC3)CC1 CC(C)C1=NO[C@H1](C(=O)N2CCN(C(=O)C3(C#N)CC3)C[C@@H1](C)C2)C1 CCC=1C=C(C(=O)NCC[C@H1]2CCN(C(=O)CO[C@@H1](C)CC)CC2(F)F)SC=1C C[C@H1](O)[C@@H1](NC(N)=O)C(=O)NCC1(O)CN(C(=O)C2=CC(O)=CC=C2F)C1 CC1=COC=C1C(=O)NC[C@H1]2C[C@H1](NC(=O)C[C@@](C)(C(F)F)N(C)C)C[C@H1]2O O=C(CC1=CC=C(F)C=N1)N[C@H1]2C[C@@H1]3CN(C(=O)C4=CC(Cl)=CC(Cl)=N4)C[C@@H1]3C2 CC[C@@H1](C)CCCC(=O)N[C@H1](CN1C=CC=N1)C(=O)NC[C@@H1](O)CC2CCCC2 CS[C@@H1](C(=O)N(C)CCNC(=O)[C@@H1]1CC(=O)OC1(C)C)C(C)(C)C CC1=CC=CC=C1O[C@@H1](C)CNC(=O)NC[C@H1](CO)CC2=CC=CC=C2Br CC/C=C/C[C@@H1](C)C(=O)NC(C)(C)/C=C/C(=O)N[C@H1]1C[C@H1](CO)C12CCC2 CC1=CC=NC=C1C=CC(=O)N2CCC[C@H1](C)[C@H1]2CNC(=O)C[C@H1]3CC=CCC3 CC1=CN(C(C)(C)C(=O)NC2CN(C(=O)[C@H1](O)C3CCCCCCC3)C2)C=N1 COCCC(=O)N[C@@H1]1CC[C@](C)(CNC(=O)C2=CC(C(F)(F)F)=CC=C2Cl)C1 C[C@H1](C(=O)N1C[C@@H1](F)C[C@H1](NC(=O)COCCCF)C1)C2CCOCC2 CN1C=CC(CC(=O)N[C@@H1]2C[C@]23CCN(C(=O)[C@@H1]4OC(C)(C)OC4(C)C)C3)=N1 O=C(NCC1=CN=CC=C1Cl)[C@H1]2CCN2C(=O)CO[C@@H1]3CCCOC3 CN(CCCCN(C)C(=O)[C@@H1]1CCN1C2CCCC2)C(=O)CC=3C=CON=3 CC1=CC=C(NC(=O)[C@H1](NC(=O)[C@H1](C)C(F)F)C2=CN(C)N=N2)C=C1C CC(C)(C)CC(=O)NCC(=O)NC[C@@H1]1C[C@H1]2CC[C@H1]1N2C(=O)C3=CSC(O)=N3 CC[C@@H1](C(=O)N1CCC[C@@]12CCCN(C(=O)C3=CN=CC(N)=N3)C2)N4C=CN=C4 CN(C)[C@@H1](CO)C(=O)N1CC(O)(CNC(=O)C2(N3C=NN=N3)CC2)C1 CCNC(=O)[C@@H1]CCCN(C(=O)C1=CC(C2=C[NH1]C(=N)C(C)=C2)=CN=C1Cl)C C[C@@H1]1CCCCN1CCC(=O)N2C[C@@H1]3CCN(C(=O)C4=NC=CC(Cl)=C4Cl)[C@@H1]3C2 CC(C)OC1=CC=CC(C(=O)N2CC(C)(NC(=O)[C@@H1]3C[C@@H1](C)CCO3)C2)=C1 COC(=O)N[C@H1](C)CNC(=O)C[C@@H1]1C[C@@H1](NC(=O)[C@@H1]2[C@@H1]3CC[C@@H1](F)[C@@H1]32)C1(C)C C[C@@H1](C(=O)N1CCCC[C@@H1]1CN(C)C(=O)C2=N[NH1]C=C2Cl)N3CCC3 C/C=C/CCCCC(=O)N1CC(COC)(NC(=O)C=2C=C(CC(C)C)[NH1]N=2)C1 CC1(C)C[C@@H1]1CC(=O)N2C[C@H1]3COC[C@@]3(C(=O)NC4=CC=CC5=C4OCC5)C2 C#CC[C@H1]1CCCCN1[C@H1](C(=O)NC2CC(C(=O)OC)C2)C3=CC=CC(Cl)=C3Br CCC[C@@H1](O)C(=O)N1C[C@H1](NC(=O)C2=C(C)C=C(C)N=C2O)CCC13CCC3 C=C(C)CN1N=NN=C1[C@H1](NC2CC(CC)(CC)C2)C3=CC=C(CC)C=C3C CN(C(=O)CCC(C)(C)F)[C@@H1]1CCCC[C@@H1]1NC(=O)[C@H1]2C(F)(F)C23CCC3 COC=1C=C(C(=O)N2CC[C@@H1]2CNC(=O)CC3=CSC(Br)=C3)[NH1]N=1 CCOC(=O)[C@@H1]1CCC[C@H1](NC(=O)C(=O)N2CC[C@@H1](C3=CC=CC=C3)C2)C1 CCCC(=O)NCC(=O)NCC(C)(C)OCCNC(=O)C1=CC=CC(C)=C1Cl CN1N=CC2=CC=C(CCC(=O)N3CCC[C@]34CCCS(=O)(=O)C4)C=C21 CN(C)CCCCCCCNC(=O)N[C@@H1]1CCN(C=2C=CN(C)N=2)C1=O NC(=O)C(=O)COC(=O)CC1=CSC(C=2N=C[NH1]N=2)=N1 C=C(Cl)CCC(=O)N[C@H1]1C[C@](C)(NC(=O)C=2C=C3C=CC(Br)=CN3N=2)C1 CN(C(=O)C[C@H1]1CCCO1)C2CCN(C(=O)C3=CC4=CC=C(F)C=C4[NH1]3)CC2 CC1=CON=C1C(=O)NCC2(NC(=O)COC3(C)CCCC3)CCCC2 C#CCN1CCC(C(=O)N[C@H1](C)CCCCNC(=O)[C@@H1](C)C2=CC=C(Cl)S2)CC1 CC(C)[C@H1](C(=O)NCCN1CC(CF)C1)[C@H1](C)NC(=O)CCC2=NC=CN2C CCCN1N=CC=C1C(=O)NCC23CCC(CC2)CN3C(=O)C[C@H1]4CCC[C@H1]4C CNC(=O)[C@H1](CCCC1=CC=C(C)C(C)=C1)N2CC[C@H1]3CN(C)CC[C@H1]32 CC(=O)OC(C)(C)C(=O)N1CCN(C(=O)C2=CN=C(O)S2)[C@@H1](C3CC3)C1 CCC1=CC(OC)=CC=C1C(=O)NC[C@H1](CNC(=O)C2=CC=C(C#N)C=N2)OC COC1=NC=C(Br)C=C1CNC(=O)N2CCC(CCC(N)=O)CC2 CC(C)C1=CC2=CC=CC(CN3C[C@H1]4CC[C@H1]3CN4CCCO)=C2O1 C=CC=CCC(=O)N1CCN(C(=O)CC2=C(F)C=CC(F)=C2Br)[C@@H1](C)[C@H1]1C O=C(NC[C@@H1]1C=C[C@H1]2C[C@@H1]1CO2)C3=CCN(C(=O)C4=NC=NC(O)=C4F)CC3 C[C@@]1(C2=CC=C(C(=O)NCCCCCNC(=O)[C@H1](O)CF)C=C2)CC1(F)F COCCN1C=CC(C(=O)N2CCN(C(=O)C3=CSC(Cl)=N3)C[C@H1]2C=4C=N[NH1]C=4)=C1 CC=1C=C(C(=O)N[C@@H1]2CC23CCN(C(=O)C(C)(C)C4=CN=CO4)CC3)SC=1C COC(=O)N1CC(CNC(=O)C2=CC=C(P(C)(C)=O)C=N2)C1 CC1=CC(C#N)=CC(C)=C1S(=O)(=O)N2CCC[C@@H1]2CCCC(C)C O=C(NC[C@]1(O)CCN(C(=O)C=CC2=CN=C[NH1]2)C1)C=3SC=CC=3N4C=NN=N4 C[C@@H1](CC1=CC=C(F)C=C1F)C(=O)N(CC(F)(F)F)[C@@H1]2CCOC2 CO[C@H1](CN1CC(=O)N(C[C@H1](C)C2=CC=CC=N2)C1=O)C3=CC=C(Br)C=C3 O=C(N[C@@H1](CCO)C(F)(F)F)C12CC(C1)[C@H1](C(F)(F)F)N2 CC1=CC([C@@H1](NCC2=CC(C(C)C)=NO2)C3=NN=NN3[C@H1]4CCOC4)=CC=C1F CCC[C@H1](C)N(C)CCC(=O)NC[C@@H1](C)NC(=O)C1=CC=CC(C(C)C)=C1N C=C(Br)CC(C)(C)C(=O)NCC[C@@H1]1CCCCN1C(=O)C=2C=C(O)N(C)N=2 CCCCCC(=O)N[C@@H1]1CC[C@@]2(CCN(C(=O)C=3SN=CC=3C)C2)C1 CC(C)OCCCNC(=O)[C@]1(F)CCN(C(=O)[C@H1]2CC3(CC3)CO2)C1 CC=CC=CC(=O)NC[C@]1(F)CCN(C(=O)C(F)(F)SC=2C=NN(C)C=2)C1 C#CC1(C(=O)N2CC(N(C)C(=O)C3=CC=CC(S(=O)(=O)NC)=C3)C2)CCCCC1 C[C@@H1](CCCNC(=O)C1=NC(=O)N(C)[NH1]1)NC(=O)C2=C(F)C=NC=C2Br CCN1N=C(C(=O)N[C@@H1]2C[C@@H1](O)[C@@H1](CNC(=O)[C@@H1]3[C@@H1](C)[C@H1]3C)C2)C=C1C4CC4 C=CC1(C(=O)N[C@H1]2COCCN(C(=O)CSCCN(CC)CC)C2)CCOCC1 C[C@]1(C(=O)N[C@@H1]2C[C@H1]2CNC(=O)CC3(C#N)CCC3)CC1(Cl)Cl C[C@@]1(CCNC(=O)CC=2C=N[NH1]C=2)CCN(C(=O)CC3=CSC=N3)C1 CC1=NN(C)C(C)=C1C[C@@H1](C)C(=O)NC[C@@H1]2CN(C(=O)C(=O)N(C)C)CCCO2 CC1=C(C(=O)N2CC[C@H1](CNC(=O)CCN3N=C(C)C=C3C)C2)C(C)(C)CCC1 CC1=CC(F)=NC=C1C(=O)N(C2=NC=C3[NH1]N=CC3=N2)[C@H1]4CCCNC4 CCS[C@@H1](C)C(=O)N1CC[C@@H1](N(CCO)C(=O)C2=CC=C(S(=O)(=O)CF)N=C2)C1 CN(CC(C)(C)NC(=O)C=1C=CN(C2CC2)N=1)C(=O)C3=CC(F)=CN=C3O O=C([C@@H1](O)C1CC1)N2CCC(N(CCO)C(=O)[C@@H1](F)CC3CCOCC3)CC2 CCCC=1[NH1]N=C(C(=O)N[C@@H1](C)CNC(=O)C2=C[NH1]N=C2Cl)C=1[N+1](=O)[O-1] C#CC1=CC(Br)=CC(C(=O)N2CCC(F)(CNC(=O)C3CC(C)(C)C3)CC2)=C1 CC(C)[C@@H1]1CN(C(=O)C=2[NH1]C=NC=2C#N)CCN1C(=O)COCCN(C)C CCN(C)[C@H1]1C[C@@H1](C(=O)N2C[C@H1](O)C[C@H1]2CC(=O)NC3=CC=C(F)C(CO)=C3)C1 O=C(NCC(F)F)[C@@H1](C1=NC(CO)=CS1)N2CCC(CN3C=CN=C3)CC2 CC1=C(C(=O)N2CC[C@H1](NC(=O)C3=CN=C(C4CC4)[NH1]3)[C@@H1](C)C2)SC5=NC=CN15 CC1=NN(C)C=C1C(=O)NC2(C3CCN(C(=O)[C@H1]4[C@H1]5C(=O)CC[C@H1]54)CC3)CC2 CC1=CN=CC=C1C(=O)N2CCC[C@@H1](NC(=O)[C@@H1](NC(=O)C(C)(C)C)C(C)C)C2 O=C(CC1=CN=C(C2CC2)[NH1]1)NC3CN(C(=O)C4=CN=C5C(=C4)CCC(=O)N5)C3 C[C@H1]1[C@@H1](C)[C@@H1]1C(=O)N2CCN(C)C[C@H1]2CNC(=O)C3=CC=C(C=4N=C[NH1]N=4)C=C3 CCOCC(=O)N1CCC2(CCC2)[C@H1](CNC(=O)CCCS(N)(=O)=O)C1 CC(=O)NC1=CC=C(C)C(C(=O)NCCCN(CC=2C=C(C)SC=2C)C3CC3)=C1 CO[C@H1]1C[C@@H1](C(=O)N[C@@H1]2[C@H1]3CCN(C(=O)CC4=CN=C(C)S4)[C@H1]32)C1 CCCN1C=CN=C1CNC2=NC=NC(N3CCC[C@@H1](N(C)S(C)(=O)=O)C3)=C2C CC1(C)CCCO[C@@H1]1C(=O)N2CC[C@H1](CNC(=O)C3=CC=C(O)N=N3)C24CC4 C[C@H1](NC(=O)C1=CC=CS1)C(=O)NCC(C)(C)CNC(=O)CC(C)(C)C(C)(F)F CCS(=O)(=O)CCN(C)[C@H1](C(=O)NCC1=CC=C(F)C=C1)[C@H1]2CCC[C@@H1](CC)C2 C=CCNC(=O)[C@H1](C1[C@@H1]2CCCC[C@@H1]12)N3CCC(NC(=O)C(N)=O)CC3 CC(=O)NCCCC(=O)N[C@@H1]1CC[C@H1](CCNC(=O)CCN2CCCS2(=O)=O)C1 CC/C=C/CC(=O)N1CC(C[C@@H1](C)NC(=O)C[C@H1]2COC(C)(C)CO2)C1 CNC(=O)[C@@H1](C1=CC=C(OC)C(OCCO)=C1)N(C)CC2=CC(Cl)=CS2 CC(C)N(CCN(C)C(=O)[C@](CCC1=CC=CC=C1)CC(C)(C)C)C(=O)[C@H1](C)O CC1=NO[C@H1](C(=O)N(C)[C@@H1]2CN(C(=O)C=CC3=CC=CN=C3)C[C@H1]2O)[C@H1]1C CCN(C[C@@H1](C)NC(=O)C=1C=C[NH1]C(=NCC)C=1)C(=O)C2=CN=C(SC)S2 C#CCC(C)(C)NC(=O)[C@H1]1C=CCCN1C(=O)C2CC3(CC[C@H1]3O)C2 CC(C)CC[C@@H1](NC(=O)[C@@H1]1CCC(F)(F)C1)C(=O)NCCCF C=C[C@H1](C)N=C1[NH1]C(=NC[C@H1](C)N2CCCCCC2)C=3[NH1]C=CC=3[NH1]1 COC(=O)C=1N=COC=1C2=CC=CC(NC(=O)[C@@H1](O3)C=CON3)=C2 COCC1(CNC(=O)[C@H1](C)C(F)(F)F)CCN(C(=O)C2=CSC=3N=NSC2=3)CC1 CN(C[C@@H1]1CCCS1)C(=O)C2(CCNC(=O)C3=CC=C(C#N)S3)CC2 C/C=C/C[C@H1](C)C(=O)N(C)CCN(C)C(=O)[C@@H1]1C[C@H1]1C2=CC=CC(F)=C2 C#CC[C@]1(O)C[C@@H1](C(=O)N2CC[C@](O)(CCNC(=O)[C@H1]3C[C@H1](SC)C3)C2)C1 CC=1ON=CC=1C(=O)N2CCN(C(=O)C3=CC=C4C=NC=NC4=C3)CC(C)(C)C2 CC[C@]1(C)C[C@H1]1C(=O)N[C@@H1]2CCCCC[C@H1]2NC(=O)[C@H1]3C[C@@H1](NS(C)(=O)=O)C3 COCCN(CCNC(=O)C1=CC=CC(F)=C1F)C(=O)[C@]2(C#N)CC23CCC3 COC1=C(CN[C@@H1]2C=C[C@@H1](C(=O)NC3CCN(C)CC3)CC2)C=CC=C1C(C)C CO[C@]1(C(=O)N[C@@H1](CO)CNC(=O)CC2(CS(C)(=O)=O)CC2)CCCC(C)(C)C1 COCCC[C@H1](NC1=CC=C(N2C=C(C)C=N2)C=C1)C3=NN=NN3C4CC4 CC1=CC=C(C=2C=C(C(=O)N[C@H1](C)[C@@H1](C)NC(=O)C3=CN=CS3)ON=2)C=C1 C#C[C@]1(C(=O)N(C)CC(=O)N(C)C)CCN(C(=O)CN2C[C@@H1]3C[C@H1]3C2)C1 C=CCCC1=CC=C(C(=O)N2C[C@H1](O)C[C@@H1](NC(=O)COCCSC)C2)C=C1 C[C@@H1](C[C@@H1](C)NC(=O)C1=CN(C)[NH1]C1=N)NC(=O)C=CC2=CC=C(C(N)=O)O2 O=C(CCN1C=NC=N1)NC2CC(CCNC(=O)C3=CC(Cl)=CC=C3F)C2 O=C(C[C@H1]1COCCN1C(=O)[C@@H1]2[C@H1]3CCCC[C@H1]32)N[C@H1](CO)C4CC4 CCC(C)(C)C(=O)N1C[C@@H1](CNC(=O)C2=CC=CN3C=NC=C23)CC(C)(C)C1 C#CC[C@H1](C(=O)NC1=CC=C(NC(=O)C2=CC(C)=NC(O)=C2)C(C)=C1)C3CC3 CCOC(=O)COCCN=C(NCC(F)F)NCCC=1C=CSC=1 C[C@H1](CO)C1CCN(C(=O)CCCC(=O)C2=CC=C(Cl)C(Cl)=C2)CC1 C=C[C@H1]1CN(C(=O)C2(C)CSC2)C[C@H1]1NC(=O)C=3C=NN(CCC(F)(F)F)C=3 CN(C(=O)C1=CC(C2CC2)=NO1)C(C)(C)CC(=O)NOCC3CCOCC3 C#CC[C@H1](C)N(C)C(=O)C1=CC[C@H1]2CC[C@H1]1N2C(=O)C[C@@H1](C)C3CC3 CC1(C)C[C@@]1(C)CNC(=O)[C@@H1]2CN(C(=O)C3=C(C#N)C=NN3C)CC2(F)F O=C(CCNC(=O)CNC(=O)C1=CN=CC=2[NH1]C=CC1=2)NO CO[C@@H1]1CCC[C@H1]1N2C=C(C3(F)CN(C(=O)C4=NC=CC=5C=C[NH1]C4=5)C3)N=N2 C[C@@H1](C#N)NC(=O)[C@@H1]1CCC=2N=C(C=3C=NN(C(C)(C)C)C=3)SC=2C1 C=C(Br)CCC(=O)NC[C@@H1](C(=O)OC)C1=CC=CC(Br)=C1 CC1=CC=C([C@@H1](C)C(=O)N2C[C@@H1]3CN(CC4=NN=CN4C)CC[C@H1]3C2)S1 CC(C)[C@@H1](C)CN(C)CCC(=O)NCCC1(NC(=O)C2=CC=CN=N2)CCCC1 CSC=CC(=O)NC[C@@](C)(O)C1CCN(C(=O)[C@H1](CC(C)C)N2C=CN=C2)CC1 CCC1=CC=CC(C(=O)N2C[C@H1]3[C@@H1](N(C)C(=O)CNC=O)CCC[C@H1]3C2)=C1 CC(C)(NC(=O)CCCC1=C(F)C=CC=C1F)C2=CN(C3=CC=CC=C3CO)N=N2 CC1=CC=C2SN=C(C(=O)N[C@@H1]3[C@H1]4CCN(C(=O)C5=NN(C)C=C5C)C[C@H1]43)C2=C1 CC1=CC=C(C(=O)NCCCN(C(=O)[C@@H1](C)N2CCOCC2)C3CCCC3)C=C1 C=C1CC(C(=O)N2C[C@@H1]3CCN(C(=O)C45CCOC(C)(C4)C5)C[C@@H1]3C2)C1 C=CC/C=C/CCC(=O)NC[C@@H1]1CCC12CCN(C(=O)[C@@H1]3[C@H1]4CCCO[C@H1]43)CC2 CC(=CC1=CC=CO1)C(=O)N[C@H1]2C[C@H1](C)N(C(=O)CC3=CC(O)=CC=C3Br)C2 COC1=CC=C(OC)C(NC(=O)NC(C)C)=C1OC CSC1=CC(C(=O)N2CC3(CCN(C(=O)[C@]4(C)CCO[C@H1]4C)C3)C2)=CC=C1F [N-1]=[N+1]=N[C@H1]1CN(C(=O)[C@@H1](F)C2CCC2)C[C@H1]1NC(=O)C3=NC(Cl)=CS3 COCCN(CCNC(=O)C1=CC2=C([NH1]1)CCCC2)C(=O)[C@H1](C)C3=CC=NN3C C[C@@H1](C(=O)N1CC2(CN(C(=O)COCC3CCCC3)C[C@H1]2CO)C1)C4(O)CCC4 CCCC=1C=C(C(=O)NCC[C@H1](O)CNC(=O)[C@H1](F)CC)N(C)N=1 CC[C@@H1](CNC(=O)C(=O)C1=CC=C(F)C=C1)NC(=O)C2=CSC(C(F)F)=N2 CCCCC[C@H1](O)C(=O)N1C[C@H1](C)[C@@](C)(C(=O)NO[C@H1]2C[C@H1]3CC[C@H1]2C3)C1 CCOC(=O)C1=CN=C(C)N=C1NC(=O)C2=CC=C(F)C(C3CC3)=C2 CC1=CC=C(CNC(=O)C2(F)CCN(C(=O)C=3C=C(C)OC=3C)CC2)O1 C[C@@H1]1CC[C@@H1](CC(=O)NCC2(CO)CCN(C(=O)C3=COC4=C3COC4)CC2)O1 CC1=NC=C(C(=O)N[C@@H1]2CC3=CC=CC=C3[C@H1]2NC(=O)C(C4CC4)C5CC5)[NH1]1 CC1=NOC(C)=C1[C@H1](C)CC(=O)NC[C@@H1]2[C@H1](C)CCN2C(=O)C3=CC=CN=C3N CCS(=O)(=O)CCNC(=O)C[C@H1]1CC[C@@H1](NC(=O)C2=C(C)C=NN=C2O)C1 CC(=O)N(C)CCCCC(=O)N1[C@H1]2CC[C@@H1]1C[C@@H1](NC(=O)[C@H1](C)NC(N)=O)C2 COC1=CN=CC(C(=O)N[C@](C)(CNC(=O)C2=CC=C(C)C(C)=C2N)C(C)C)=C1 CC(C)[C@@H1](C(=O)NC1CC(CNC(=O)C[C@H1]2CCOCC2(C)C)C1)N3C=CC=C3 CCN1CC[C@@H1]1C(=O)NC[C@@H1]2C[C@@H1]3CC[C@H1](C2)N3C(=O)C4=CC=C(CCF)C=C4 CC=1N=NN(C)C=1C(=O)NCCCCCNC(=O)[C@H1]2CCN3C(C)=CN=C3C2 CC1(CCC(=O)NC2CCCCCCC2)CN(C(=O)[C@H1]3CCCN3C4CC4)C1 C=C(C)[C@@H1]1OCC[C@@H1]1C(=O)N[C@H1]2CC(=O)N(C3CN(C(=O)C4CCSCC4)C3)C2 COC[C@H1]1CC[C@@H1]1C(=O)N2CC[C@H1](CNC(=O)C3=CC=C(F)C(C)=C3C)C24CC4 C[C@@H1]1CCC(Cl)=C(C(=O)NC[C@@H1]2CCCCN2C(=O)C=3C=C(CO)[NH1]N=3)C1 CC1=NN(C)C(=O)[C@@H1]1CC(=O)N(C)[C@H1]2CCCN(C(=O)[C@H1](F)C3(O)CCCC3)C2 CC=1C=CSC=1C=CC(=O)N2CCC[C@H1](C)[C@H1]2CNC(=O)CC3(C)CCC3 CC1=NC=CC=C1C(=O)N2CC(C[C@H1](C)NC(=O)[C@@H1](O)C3CCOCC3)C2 C[C@@H1]1C[C@H1](C(=O)N2CCN(C)C(C)(C)C2)CCN1C(=O)C3=NC=CC=C3Cl CC1=CC=NN1[C@H1](C)C(=O)NCC[C@@H1](NC(=O)[C@@H1]2CC23CC(F)(F)C3)C(C)C CN(CC(=O)N[C@H1]1C[C@H1](N=C2[NH1]C3=CC=CC=C3O2)C1)S(C)(=O)=O CC(C)N1N=CC(C(=O)NC(C)(C)CCCNC(=O)C2=CC=C(O)C(F)=C2F)=N1 C[C@@H1](C1=CSN=N1)N2CCC[C@](C)(CNC(=O)CCC3=CC=CC=C3Cl)C2 COC(=O)[C@@H1]1C(C(=O)NC[C@@H1](C)CNC(=O)C(C)=C2CC2)[C@H1]1C(=O)OC CN(CC1(O)CCN(C(=O)C(N)=O)CC1)C(=O)C2=CC3=C(S2)C4(CCC4)CC3 COC(=O)CS(=O)(=O)CC(=O)NCC1(O)CN(C(=O)[C@@H1](O)CCSC)C1 CN1N=CC(C(=O)NC[C@@H1](NC(=O)/C=C/[C@H1]2CCCO2)C3CC3)=C1C(F)F COCCS(=O)(=O)N1CCN(C(=O)C2=CC=C(Br)C=C2I)C[C@H1]1C#N CSC[C@H1](O)C(=O)NCC(C)(C)CCNC(=O)[C@]1(C)CC1(F)F CC(=O)N1CCC[C@@H1](NC(=O)C(=O)N[C@@H1](CCC(F)F)C(N)=O)C1 COC1=CC=C(C(=O)N2C[C@@H1]3CCN(C(=O)C4=CC=CC(F)=C4O)C[C@@H1]3C2)N=C1 CCOC(=O)C1=CON=C1C(=O)N[C@H1](C)[C@@H1](C)NC(=O)C=2SC=CC=2C#N CC1=CC=C(C)N1CC(=O)NC[C@@]23C[C@@H1](CCO2)N(C(=O)CSC(C)(C)C)C3 CC1(C)[C@H1](NC(=O)C2=CSC=N2)C[C@H1]1C(=O)NCC3CC4(CC4)C3 COCCCCCC(=O)NCC[C@@H1](C)NC(=O)C1=CN=C2C=CC(C#N)=CN12 CCC#CC(C)(C)NC(=O)C1CCN(C(=O)/C=C/C2=CC=C(C)C=C2)CC1 CSCCCNC(=NCC=CC)N[C@@H1]1C[C@H1]1C2CCC2 CNC1=CC=C(C(=O)NCC[C@H1](O)C(=O)N2C[C@H1]3CCN(C)C[C@@H1]3C2)C=C1 CO[C@H1](CCNC(=O)CC1=NON=C1C)CNC(=O)[C@H1]2[C@H1]3CC[C@@H1](C3)C2(C)C O=C(NC1=C(O)C=CC=C1O)[C@@H1]2CC[C@H1](C3CC3)N2C(=O)C4CC(CF)C4 CC1=CC(C(=O)N2CCOCC[C@@H1]2C(=O)NCC3CCC3)=C(N)S1 CCCC1(CNC(=O)CN2CCN(C(=O)[C@H1]3C[C@@]3(F)Cl)CC2)CCC1 COC[C@@H1]1C[C@H1]1C(=O)NC[C@](C)(O)CNC(=O)CCC2=CC(Br)=CS2 CC(C)(O)[C@@H1](NC(=O)[C@@H1]C1CN(C(=O)CCC2=CCCCC2)C(C)(C)C1)C3CC3 CC=1C=C(C(=O)N2CCN(C(=O)C3=C(C)C=CN3C)C4(CC4)C2)SN=1 CCC[C@@H1](CC)CC(=O)N(C)[C@@H1]1CN(C(=O)C2=CC=NC(C)=C2C)C[C@H1]1O CC(=O)NCC(=O)NC[C@@H1]1COCCN(C(=O)CSC2=NN=NN2C)C1 COCC[C@H1](NC(=O)[C@H1]1CCC[C@H1]1F)C(=O)N2CCC(CCCO)CC2 O=C(NC1=CC2=CC=NN(CCCO)C2=C1)C3=CC=C(F)C([N+1](=O)[O-1])=C3 CO[C@H1](CC(C)C)C(=O)N1CCC[C@H1]([C@H1]2C[C@@H1]2NC(=O)CN3C=NC=N3)C1 C[C@@]1(CC(=O)N2CCC[C@H1](C(F)F)C2)CCN1C(=O)C3=C[NH1]C(=S)C=N3 CC[C@H1](CN(C)C(=O)C1=CSC(C)=C1OC)NC(=O)C=2C=C(C3CC3)[NH1]N=2 CC(C)(C)C(=O)CNC(=O)C1=CC=C(CN2C=C(CNC(N)=O)N=N2)O1 C[C@@H1](NC(=NC[C@H1]1CCN(S(C)(=O)=O)C1)NCCN2CCCCC2)C=3N=C[NH1]N=3 O=C(NC[C@]1(CO)CCN(C(=O)[C@H1]2C[C@H1](N3C=CN=N3)C2)C1)C4CC(CF)C4 CCN1C[C@H1](C(=O)N[C@H1]2CC[C@H1](NC(=O)[C@@](C)(O)C(C)(C)C)CCC2)CCC1=O CN1CC2=CC=CC=C2[C@@H1]1CN=C(NC3CCCC3)N[C@@H1]4CCC4(C)C CC1=CC=C(NC(=O)CCNS(=O)(=O)C2=CC=CC=C2C3=CC=C(C#N)C=C3)O1 CCC[C@@H1](OCC)C(=O)N(C)CCOCCCNC(=O)CCCC1=CC=C(C)S1 CN(C(=O)CC1CC2(CC2)C1)[C@@H1](CNC(=O)C=CC=3C=NN(C)C=3)C4CC4 CCCC=CC(=O)N1C[C@@H1]2CCN(C(=O)C3=CC=C(C#CC4CC4)C=C3)C[C@@H1]21 C[C@@]12CC[C@@](CCNC(=O)[C@H1]3COCCN(C(=O)C4=CC=C(F)C=C4)C3)(CO1)C2 CC=1C=NN(CCCNC(=O)[C@@H1]2C[C@H1](C)CCN2C(=O)C3C[C@@H1]4CCC[C@H1]4C3)C=1 CCC1=CC=C(C(=O)NC[C@H1]2CCC[C@@H1](NC(=O)[C@H1]3C[C@@H1]3COC)C2)O1 CN(CC(=N)NOCCCOC1=CC=CC=C1C#N)C2CC2 C=CCCCC(=O)NC[C@](C)(CO)NC(=O)C1=NC(C)=C(C)N=C1C CC1=NO[C@](C)(CNC(=O)[C@]23CCN(C(=O)[C@@]45CC[C@@H1](C4)O[C@H1]5C)CC[C@H1]2C3)C1 O=C(CCC1=CC=C(F)C=C1)N[C@H1]2C[C@H1](O)CN(C(=O)[C@@H1](F)N3C=CC=N3)C2 C[C@@]1(C2=CC=CC=C2)CCN1C(=O)CC3=CN=CN=C3O CC(=O)NC(C)(C)C(=O)NC1=CC=CC(C(C)C)=C1 C[C@](CNC(=O)[C@H1]1CCCCC(=O)N1)(NC(=O)C#CC2CCC2)C3CC3 O=C(C1=CC(=O)C=C(Cl)[NH1]1)N2CC[C@H1](CNC(=O)C3(C4=CC=NC(Cl)=C4)CC3)C2 CC1=NC=CC(C(=O)N[C@@]2(C)CCN(C(=O)C(C)(C)NS(C)(=O)=O)C2)=C1C CC1=NN(C)C(C(=O)NC[C@]23CN(C(=O)CSCCC(C)C)C[C@H1]2CCO3)=C1Cl CC=1C=C(C(=O)N2CCC[C@H1]2CCNC(=O)C3=CN=C([C@@H1]4CCOC4)S3)ON=1 O=C([C@@H1]1CC2(CC2)CN1C(=O)CN3CCOCC3=O)N4CCC5(CCOC5)CC4 COC1=CC(NC(=O)[C@@]2(C)CCCN2CC3=CN=CC(O)=C3)=NC(C)=N1 O=C(/C=C/C1=CC=C(Br)C=C1)N2CC[C@](O)(CN3C=C(CC45CC(C4)C5)N=N3)C2 C[C@]1(NC(=O)CCC(CF)CF)C[C@@H1](NC(=O)CN2C(=O)CCC2=O)C1 CC(=O)CCNC(=NCC[C@@H1]1CCO[C@H1](C)C1)NCC2(CS(C)(=O)=O)CCC2 CC/C=C/C[C@H1](C)C(=O)N1C[C@H1](F)[C@H1](NC(=O)C2=NC=C(Br)C=C2F)C1 COCC1=CC=CC(NCC2=CC(C)=NC(OC)=C2)=C1 C[C@H1]1[C@@H1](C)N(C(=O)CCCC2=NN=CN2C)CCN1C(=O)CCCCCC#N CC1=CC=C(CCC(=O)NC[C@H1]2CCN(CC3=CC4=CC=CC=C4O3)C2)C(C)=N1 CN(C)CC(=O)NC1(C)CN(C(=O)[C@H1]2CCCN(C3=CC=NC=N3)C2)C1 O=C(C1=CC=C(CO)O1)N2C[C@H1]3[C@@H1](NC(=O)C4([C@@H1]5CCCO5)CCCC4)C[C@H1]3C2 O=C1CCCCCN1[C@H1]2CCCN(C(=O)C34CC(CO)(C3)C4)CC2 CCC(CC)(CNC(=O)C1=CC([N+1](=O)[O-1])=CC=C1C)NC(=O)CC[C@@H1](C)SC C[C@H1]1C[C@@H1](C)O[C@@H1]1C(=O)N2C[C@H1](NC(=O)CCN3N=CC4=C3CCCC4)C[C@H1]2C CSCCCNC(=O)[C@H1](CCC1CCCCC1)N2CC[C@H1](C(N)=O)C2 COC1=CC=NC(F)=C1C(=O)O[C@H1](C(=O)C2CC2)C(C)C CC1=C(CC(=O)NC[C@H1]2CC3(CC3)CN2C(=O)C=4C=C(C(C)C)ON=4)N=CN1C C#CCS(=O)(=O)N1[C@H1]2CC[C@H1]1CC(NC(=O)C3=C(C)OCCS3)C2 COCC1=NC(C(=O)N(C)C2(CC(=O)N3CC[C@H1]3CC4CC4)CC2)=CO1 CCCC[C@@H1](CNC(=O)C[C@H1](C)C1=CC=CN=C1)NC(=O)C2=CC(C)=NC(O)=N2 C#C[C@H1]1C[C@H1]2CC[C@H1]1N(C(=O)[C@H1]3CCN(C(=O)[C@]45CSC[C@H1]4C5)[C@@H1]3C(C)C)C2 CC(C)[C@](C)(O)C(=O)N1CC[C@@H1](CCNC(=O)[C@H1](C)C2=CC=CC=N2)C1 C=CC[C@]1(C(=O)N(C)CC2CN(C(=O)C3=CC(N)=C(F)C=N3)C2)CCOC1 COC1=CC=CC(C(=O)N[C@H1](C)CCCC(=O)NCCN2C=NN=N2)=C1 COCC(C)(C)CC(=O)N1C[C@H1](C)C[C@H1]1C(=O)NCC[C@@H1]2CCCC[C@H1]2O CC1(C)C[C@@H1](NC(=O)C2=COC(CNC(=O)[C@H1]3CCC4(CCC4)O3)=C2)CCO1 C[C@@H1]1[C@@H1](NC(=O)CNC(=O)C2CC2)C[C@H1]3CC[C@H1]1N3C(=O)C4=CN=C(Cl)C=C4Cl CCOC[C@H1](NC(=O)[C@@H1]1C[C@H1](O)[C@@H1](F)C1)C(=O)N2CC(F)(F)[C@H1]2C3CC3 C[C@@]12CC3CC(CNC(=O)N[C@H1](C4CCCC4)C5CC5)(C1)C[C@](C)(C3)C2 O=C(/C=C/[C@H1]1CCCN1C(=O)CCCCCF)N2C[C@H1]3C[C@H1](C[C@@H1]3CO)C2 O=C(NC1=CC(Cl)=CC(Cl)=N1)[C@@H1]2CCCN2C(=O)CNCC3=C(Cl)C=CN=C3Cl CC(C)(CCC#N)C(=O)N1CCO[C@@H1](CNC(=O)CCCOC2=CC=CC=C2F)C1 CN1C(C(=O)NC[C@H1](NC(=O)C2=CC=C3[NH1]C(=N)N(C)C3=C2)C4CCC4)=CS1 CCN(C[C@H1](C)NC(=O)C=1[NH1]C(C)=NC=1C)C(=O)C2=CC=NC3=CC=C(F)N=C23 COC(=O)C1=CSC([C@@H1](NCCOC2=CC=CC(Cl)=C2)C3=NN=NN3C4CCC4)=C1 CO[C@H1](CCSC)C(=O)N[C@@]1(CO)CCCN(C(=O)C(C)(C)SC)C1 C[C@]1(C(=O)N2[C@H1]3CC[C@@H1]2C[C@@H1](C(=O)O)C3)C[C@H1](N)CCO1 COC[C@]1(C(=O)N[C@@H1]2CCN(C(=O)C3=CN=C(Br)C(N)=N3)C2)C=CCC1 CC(=CC1=CC=CC=N1)C(=O)N[C@H1]2CCN(C(=O)C(F)(F)CO)C[C@H1]2C(C)C CCC1=CC=C(CNC2(CC(=O)NC3=CC=C(C4=CC=NO4)C=C3)CCC2)S1 NS(=O)(=O)CC1=CC=CC(C(=O)N[C@@]2(CF)CCN(C(=O)[C@H1]3CC34CC4)C2)=C1 COC1=CC=[N+1]([O-1])C(C(=O)NCCN(C(=O)C[C@H1]2C=CCC2)C(C)C)=C1 CC(=O)NCCC(=O)NCC1(O)CN(C(=O)[C@H1](C(C)C)N2C=CC=C2)C1 CCC=1C=NN(CCNC(=O)C/C=C/CNC(=O)C[C@H1]2CC[C@H1](C#N)C2)C=1 CC1=C(CC(=O)N(C)CC(=O)N2C[C@@H1](O)[C@H1](O)C2)N=CN1C CC/C(C)=C/C(=O)N[C@H1](C)[C@@H1]1CCCN1C(=O)C=2C=NN(C3=CC=CN=C3)C=2 CC(C)CO[C@@H1](C)C(=O)NC1(CCNC(=O)[C@H1](C)C2=CC=C(Br)S2)COC1 O=C(C1=CC=C(Cl)N=C1Cl)N2CCN(C(=O)C3=CC=C4C=CC=C(Br)C4=C3)CC2 CC[C@@H1](OC)C(=O)NC1(C(=O)N2CC[C@H1](NC(C)=O)C2)CC(F)(F)C1 CCOC(=O)C1(C(=O)N(CCCNC(=O)CC2=CC=NC(F)=C2F)C3CC3)CC1 COCCCN(CCOCC)[C@@H1](C(=O)NC1=CC=C(F)C=C1)C2=COC(C)=N2 CC1=CN=C(NC(=O)C2=CSC(=NCC3=CC=CC=4C=CSC3=4)[NH1]2)C=C1F CC1(C)CCC[C@@](O)(C(=O)NCC(C)(C)CNC(=O)CC2C(C)(C)C2(C)C)CC1 CCNC(=O)OC1CN(C(=O)[C@@]23CC[C@@H1](CN(C(=O)[C@@H1](C)SC)C2)C3)C1 CN1N=CC=C1CN2CCC[C@H1](CNC(=O)C3=CC=C(C(F)(F)F)C=C3)C2 CC1(C[C@@H1](C(=O)NCCCC2CC2)N3C[C@H1](C4CC4)[C@@H1]3C5CC5)CC1 CCO[C@H1]1C[C@@H1](NC(=O)[C@@]2(C)CN(C(=O)[C@H1](C)OCCOC)C(C)(C)C2)C1 NC(=O)NCCC(=O)N1CC[C@H1](NC(=O)CCC2=NC(O)=N[NH1]2)[C@H1](F)C1 CC(C)C=1C=C(CNC(=O)[C@H1]C[C@H1](O)[C@@H1](NC(=O)C2=C(Cl)C=NN2C)C)[NH1]N=1 CCCC[C@@H1](F)C(=O)N[C@H1]1CCCCCC[C@H1]1NC(=O)C2=CC(OC)=NO2 CC[C@@](C)(CN(C)C(=O)C1=CC=CC(CNC(=O)C2=CN=C(N)C=N2)=N1)OC C#CC[C@@H1](C)C(=O)N1C[C@H1]2CCN(C(=O)C3=CC=C(OC)C(Br)=C3)[C@H1]2C1 O=C(CCNS(=O)(=O)C1=CC=CC=C1Cl)NCCN2N=CC=N2 O=C(NCCC1CCN(C(=O)C[C@H1]2CCOC2)CC1)[C@H1]3C=CCC3 CCC(C)(C)CC(=O)NC1C[C@@H1]2C(NC(=O)C3=C[NH1]N=C3C(C)C)[C@H1]2C1 CCCCOC1=CC=C(C(=O)N2CCO[C@H1](CCNC(=O)CC(C)(C)OC)C2)O1 CC(C)[C@@H1](O)C(=O)N(C)CC(=O)NCCCC1CCCCC1 CCCCSCC(=O)N[C@H1]1C[C@H1]2CN(C(=O)C3=CN=C([N+1](=O)[O-1])C=C3C)C[C@@H1]21 C[C@@H1]1CN(C(=O)C2=NN[C@H1](C(F)(F)F)C2)CC3(CCN(C(=O)C4(C)CC4)CC3)O1 CC(C)(C)[C@H1](C#N)C(=O)N1CC(F)(F)C[C@H1]1C(=O)NC[C@]2(C)C=CCCC2 O=C(C1=CC(C(F)(F)F)=NC=C1Cl)N2C[C@H1]3CCC[C@H1]2C3 CSC1=CC=CC=C1NC(=O)N2CC(C)(C)C(O)C(C)(C)C2 CC1=C[C@@H1]1C(=O)N2C[C@H1](C)[C@H1](NC(=O)[C@]3(C)CCC4=CC=CC=C4C3)C2 CC1(C)CO[C@H1](C(=O)N[C@H1]2C[C@@H1](CNC(=O)CCC3=CC=CC(F)=C3Br)C2)C1 CN(C)C[C@@H1](O)C(=O)N(C)[C@H1]1CN(C(=O)C2=CC=C3C(=C2)NCC3)CC1(C)C FC1=CC=C(CN=C2[NH1]C(C3=CC(C(F)(F)F)=CC=4[NH1]N=CC3=4)=CS2)C=N1 CSC1=NC(C(=O)N2CC[C@@H1](CCNC(=O)C=CC3=CN=CC=N3)C2)=CS1 CN1N=NC=C1CC(=O)NCCOCCOCCCNC(=O)C2CCCC2 C[C@H1](CNC(=O)[C@H1]1CC=CCO1)N(C)C(=O)CCNC(=O)C2=NC=CC=C2O C#CC[C@@H1](C)C(=O)N1C[C@@H1](NC(=O)C2=CC([C@H1](C)CC)=NO2)[C@H1](C3CC3)C1 CC1=NC=C(C(=O)NCC2(O)CN(C3=NC=C(Br)C=N3)C2)S1 CC1(C)CN(C(=O)C2=CC(O)=NC=N2)C[C@H1]1CNC(=O)C3=CC4=CC=CN=C4[NH1]3 CCC1=NC=C(C(=O)N(C)C[C@H1]2CCCN(C(=O)[C@H1]3CCCN3CC)C2)C(O)=N1 CC1=CC(C)=C(C(=O)N2CCC[C@@H1]2[C@H1]3CCN(C(=O)C[C@H1]4CC[C@H1](C)C4)C3)[NH1]1 COC[C@H1](O)C(=O)N1C[C@@H1]2[C@@H1]3CC[C@@H1](CN3C4=NC=NC5=CC=C(F)C=C45)[C@H1]2C1 CC1=C[NH1]C=C1C(=O)NC2(CCCCNC(=O)C3CC(C(F)(F)F)C3)CC2 COCCO[C@H1](C)C(=O)NC1(C)CN(C(=O)C[C@@H1]2CCC3=CC=CC=C32)C1 CN1C=C(C=2OC=NC=2C(=O)N[C@@H1]3C[C@H1]3CNC(=O)C=4C=C[NH1]C(=N)C=4)C=N1 CN1N=CC(C(=O)N2CC3=N[NH1]C=C3[C@H1]2C(=O)N[C@H1]4CCOC4(C)C)=C1Cl C/C=C/CCCCC(=O)NC[C@](C)(CNC(=O)[C@]1(OC)CCSC1)OC CO[C@H1](CCSC)C(=O)NC[C@@H1](NC(=O)C1=CN(C2CC2)N=N1)C3CCCC3 CCO[C@@H1]1CC[C@H1]1CNC(=O)[C@@H1]2CC[C@H1]2NC(=O)C3(C)CCC(=O)CC3 CC1=CN=C(C(=O)N2CC[C@H1](NC(=O)C34CC(F)(C3)C4)[C@@H1](F)C2)C=N1 CC(=O)O[C@@H1](C(=O)N1CC2(CC[C@@H1](NCC3=CC(C#N)=CC=N3)C2)C1)C(C)C C[C@@H1]1C[C@@H1]1C(=O)N2C[C@@H1]3C[C@H1](NC(=O)[C@@H1](C)N4C=C(Cl)C=N4)[C@H1]3C2 COC1=CC=CN=C1C(=O)N2CCC(NC(=O)[C@@H1](O)[C@H1](C)C3=CC=CC=C3)CC2 CSC[C@](C)(NC(=O)C=CC(F)(F)F)C(=O)NCCC1CCOCC1 CN(C(=O)C1=CN2C(=N1)SCC2)[C@@H1]3CCCCN(C(=O)C4=CC=CC(=O)N4C)C3 CC1=NOC(C)=C1CC(=O)N[C@H1](CC(F)F)C(=O)N2CC[S@](=O)[C@H1](C)C2 CCC[C@H1](CCCNC(=O)C=1C=CN2C=NN=C2C=1)NC(=O)C3=NOC=C3Cl CN1N=CN=C1CNC(=O)C2(CNC(=O)CN3C=NC=N3)CCC2 C=C(CCNC(=O)C=CC1=CC=CC(C)=C1)CNC(=O)CC(C)(C)O CCCCC[C@H1](O)CNC(=O)C1(N2C=C(CN3CCN(C)CC3)N=N2)CC1 CN1CCC[C@@H1](CN=C(NC2CC2)N3CC4(CCOCC4)[C@H1]3C5=CC=CO5)C1 CC[C@@H1]1[C@H1](NC(=O)C2=COC(COC)=N2)CCCN1C(=O)[C@H1]3S[C@H1]4C=C[C@H1]3CC4 O=C([C@@H1]1C[C@H1](O)CN1C(=O)CCCCBr)N2CC[C@H1](OC3=CC=C(F)C=C3)C2 CC(C)COCCN1CCC[C@@](CO)(NC(=O)C2=CC=C(O)N=N2)C1 C#CCCO[C@@H1](C)C(=O)NCCOCCCN(C)C(=O)C1=CC(C)=NO1 CCN1CC[C@H1](C(=O)N2CC([C@H1](C)NC(=O)C3=CC(Br)=CC=C3C)C2)C1 CN(C)C(=O)[C@@H1]1CCCN(N2CCC(CC(F)F)(C(=O)OCC)CC2)C1 CC[C@H1](CNC(=O)[C@H1](C1CC1)[C@@H1]2CCCO2)NC(=O)C(F)(F)[C@@H1](O)C3CC3 CC(C)[C@@H1](CNC(=O)C=1N=CN(C)N=1)NC(=O)[C@H1](F)[C@H1]2CCOC2 CSCCCC(=O)NC1CCN(C(=O)C2=CC(Br)=CC(C)=C2C)CC1 CC[C@](C)(C#N)C(=O)N1C[C@@H1](CNC(=O)C=2C=C(C(F)F)[NH1]N=2)OC3(CCC3)C1 CC1=CC=C(C(=O)N[C@H1](C)[C@@H1]2CCN(C(=O)C(C)(C)CCF)C2)C(O)=C1 CC=1OC(Cl)=NC=1C(=O)N2CCC[C@@](C)(C(=O)NOCCC3=CC=CC=C3)C2 COC(=O)[C@H1](O)C1CCN(C[C@@H1]2CN(C)C(=O)O2)CC1 C=CCN1C=C(C(=O)N2CCN(CCNC(=O)[C@@H1](C)C3CCOCC3)CC2)C=N1 C=C[C@H1]1C[C@H1]1C(=O)N[C@]2(C)CCCN(C(=O)C3=CC=CC=C3C(N)=O)C2 CC1=CC=NN1[C@H1](C)C(=O)N(C)CCCNC(=O)[C@H1](C)NC(=O)C2CCOCC2 [N-1]=[N+1]=NCC1=CC=C(C(=O)N2C[C@H1]3C[C@@H1]2[C@H1]3NC(=O)COC4=CC=CN=C4)O1 C=C(CCNC(=O)C[C@@H1]1C[C@H1]1CC)CNC(=O)[C@H1]2CC(=O)N(C(C)C)C2 C[C@H1](CC1CCC1)NC(=O)[C@H1]2CN(C(=O)CCC=3C=CN(C)C=3)CC2(F)F C[C@@H1]1CN(C(=O)C2=CC=CC3=CC=NN23)C[C@@H1]1NC(=O)C4=CC=C(CO)C(F)=C4 CN1N=CC2=CC(C(=O)NC[C@@H1]3C[C@H1]4C[C@@H1](C3)N(C(=O)C5CC=CC5)C4)=CN=C21 O=C(NC[C@H1]1CC[C@H1](C(=O)NOCC2CCC2)CC1)C3=CC(Cl)=N[NH1]3 C=C[C@@H1](C)C(=O)NCC[C@@H1]1CCCN(C(=O)CS(=O)(=O)C(C)C)C1 C[C@@H1]1CCCC2=C(C(=O)N3[C@H1]4CC[C@@H1]3CN(C(=O)C5=CC(Cl)=CN5C)C4)C=NN21 C[C@@H1]1CCC[C@H1](C(=O)N2CCN(C(=O)CCC3=NNC(=O)CC3)C[C@H1]2CO)C1 CC[C@H1](CC(=O)NCC(C)(C)CNC(=O)C1=C(Cl)CCCC1)C(F)F COC1=CC(NC(=O)[C@@]2(O)CCN(C(=O)[C@H1]3C[C@@H1]3C4CC4)C2)=CC(C)=N1 CC(C)(CC1CCC1)C(=O)N2CCN(C(=O)C3=CC=C([N+1](=O)[O-1])[NH1]3)C4(CCC4)C2 O=C(NCCCCCNC(=O)[C@@H1](O)CC1CCCCC1)C2=C(F)C=CC(Cl)=C2F CCCCCC[C@H1](C)C(=O)N1CC[C@H1](C)N(C(=O)[C@H1](O)C2=CC=CC(N)=C2)CC1 C[C@H1](C(=O)N(C)[C@@H1](C)CNC(=O)[C@H1]C[C@H1]1[C@@H1](O)CN1)C2=CC=C(F)C=C2 O=C(N[C@]12CCN(C(=O)CCC3=NC=CS3)C[C@H1]1C2)C4=CC=C5N=CC=CC5=C4 CC1=NOC=C1C(=O)N(CCNC(=O)[C@@]23CCCC(=O)N2CCC3)C4CCCC4 CC(C)CC1(NC(=O)[C@H1]2CCC[C@H1]2NC(=O)C3(C4CC4)CC(=O)C3)CC1 CN(C)[C@H1]1CCC2=CC(Br)=CC=C2N(C(=O)C3=CC=NC4=CC(Cl)=CC=C34)C1 CC#CCCC(=O)N[C@@H1]1CN(C(=O)C2=C(C)C=CC(Cl)=C2O)C[C@H1]1SC C[C@H1](C(=O)N(C)CC1CCN(C(=O)C2(C)CC2(F)F)CC1)[C@H1](C)C3CCCCC3 COC[C@H1]1CCN(C(=O)C(=O)N2C[C@H1](F)C[C@@H1]2C#N)C1 N#CC1=CC=C(C(=O)N[C@@]23CC[C@@H1](C2)N(C(=O)C4=NC=C(F)C=C4F)C3)N=C1 CN(C)NC(=O)CCC(=O)N(CCO)[C@H1]1CCCN(C(=O)C2(CCF)CC2)C1 CC1=CC(C)=C(C(=O)N2CCC[C@H1](NC(=O)[C@H1]3CCN(C)S3(=O)=O)C2)O1 CC(=NO)[C@@H1]1C[C@@H1](C(=O)N2CCC(CC(N)=O)(NC(=O)C[C@@H1](C)F)CC2)C1(C)C CC1=CC=C(C(=O)N2CC[C@H1](C)[C@@H1](NC(=O)C3=NC=C(C(F)F)S3)[C@@H1]2C)S1 COC(=O)C1=CC(C#N)=CC=C1NC(=O)[C@H1]2CN(CC3=CC=CC(O)=N3)CCO2 CCCN(C(=O)C1=CC=NC=C1C)C2CCN(C(=O)C[C@@H1](O)C(C)C)CC2 C=CCC1(NC(=O)C2=CC=C(C(C)C)O2)CN(C(=O)[C@H1]3CCO[C@@H1]3C4CC4)C1 CCN(C)CC(=O)N(CC(=O)NCCN(C)CC(F)F)C(C)C CC1=CC(C(=O)NC[C@@]2(NC(=O)C=3OC=NC=3C4CC4)CCOC2)=NC(O)=N1 CC[C@@H1](C(=O)N(C)CCCNC(=O)C1=CC=CC=2C=COC1=2)[C@H1](C)O CCOC(=O)[C@](C)(F)C(=O)N1CCCN(CCNC(=O)CC(C)(C)COC)CC1 CC(C)N1C=C([C@H1]2C[C@@H1]2C(=O)N3CC(O)(CNC(=O)C4=NSC=C4N)C3)C=N1 CCN(C)CC=CC(=O)NC[C@@H1](C)CN(C)C(=O)[C@@H1](CC)CCC1=CC=CC=C1 CC1=CC=C(C(=O)NC[C@@H1]2C[C@@H1](CNC(=O)CCCC3CCCC3)CO2)O1 C#CCCC[C@H1](C)C(=O)NCC1=CN=CC(C(=O)N2CC(=O)N[C@H1](C(C)C)C2)=C1 O=C1CC[C@H1](C(=O)N[C@H1]2CCN(C(=O)C3=CC=CC4=C3CCCC4)C25CCC5)O1 CC(C)[C@H1](NC(=O)C12CCC(CC1)N(C(=O)C[C@H1]3NC(=O)NC3=O)C2)C4CCC4 CC(C)[C@@H1]1CCO[C@@H1]1C(=O)NCC2(O)CCN(C(=O)[C@H1]3CN4CCC3CC4)CC2 CCCC[C@@H1](CC)C(=O)N(C)C(C)(C)CC(=O)NC[C@H1]1CCCCN(C)C1 CC[C@H1](C)C(=O)N(C)CCOCCCNC(=O)[C@@H1]1CCCN(C2=CC=CC=N2)C1 CO[C@H1](C(=O)N1CCN(C(=O)C2(F)CCN(C)CC2)C[C@H1](O)C1)C3CCCC3 NC1=CC=CC([N+1](=O)[O-1])=C1C(=O)NC[C@@]2(O)CCCN(C(=O)[C@H1]3CCS(=O)(=O)C3)C2 C=CC[C@H1](C)N=C1[NH1]C(=N[C@H1]2CC3[C@H1][C@H1](C(N)=O)[C@@H1]2C3)C=4N=CN(C)C=4[NH1]1 COC1=N[NH1]C=C1C(=O)N[C@H1]2C[C@H1](CNC(=O)C3=CC=NN=C3C)C2 CC(C)[C@H1](CNC(=O)C1=CC2=CC=CN2C=N1)NC(=O)CC[C@@]3(C)CCC(=O)N3 CC[C@](C)(C(N)=O)C(=O)N[C@H1]1COCCN(C(=O)C2=N[NH1]C(C)=C2C)C1 O=C(N[C@@H1]1CCN(C(=O)CN2C=C(Br)C=CC2=O)C[C@@H1]1O)C(F)F N#CC1=CC=CC(F)=C1NC(=O)[C@@H1]2CCN(C(=O)C=3N=C4N=CC=CN4N=3)C2 CCCC[C@H1](NC(=O)[C@H1]1C[C@@H1]1C2CCC2)C(=O)NCC3=CC(OC)=NN3C C[C@H1](NC=1[NH1]C(=N[C@H1]2CCO[C@@H1](C3=CC=C(F)C(F)=C3)C2)N(C)C=1)C4CCCC4 CCC1=CC(C(=O)N[C@@H1]2C[C@@H1]3CC[C@H1](C2)N3C4=NC=NC5=CN=CC=C45)=NN1C CC(C)C1=CC=C([C@@H1](O)C(=O)N2C[C@H1](C)[C@H1](NC(=O)C#CC3CC3)C2)C=C1 C=C[C@H1](C)CCNC(=O)[C@@H1]1C[C@H1](O)CCN1C(=O)C[C@@H1](O)CC(C)C C=C=C[C@H1](C)C(=O)N1[C@H1]2CC[C@@H1]1C[C@H1]2CNC(=O)C3=CC=C(SCCCO)C=C3 NC1=CN=C(C(=O)N2CC[C@@H1]2C(=O)NC[C@@H1]3CCC(=O)N3)C=N1 C[C@H1](NC(=O)[C@@H1](N)CC=1C=COC=1)C2=NC=NN2C O=C(C1=CC=CC(Br)=C1Cl)N2CCN(CC3=NC=CC=C3O)[C@H1]4C[C@@H1]42 CCC1=C(C(=O)N[C@@H1](CNC(=O)CNS(=O)(=O)NC)CC(C)C)N=NN1CC COC1=CC=NC(CC(=O)N[C@H1]2C[C@@H1](CNC(=O)C3=CSC4=CN=CN34)C2)=N1 CCC[C@H1](C(=O)N1CC[C@](C)(C(=O)N[C@@H1](CO)CC2=CC=CO2)C1)C(C)C COC1=CC=C2OC([C@@H1](C)NC(=O)N3CC4CC3(S(C)(=O)=O)C4)=C(C)C2=C1 C=C[C@H1](OC)C(=O)N1C[C@H1]2C[C@H1]1CN(C(=O)[C@H1](C)C3CCC3)C2 CCC[C@H1](NC(=O)[C@]1(OC)CCN(C(=O)CNC2=CC=CN=C2)C1)C3CC3 CC1=CC=C(C(=O)NC[C@]23CC[C@H1]2CN(C(=O)C[C@@H1](C(F)F)N4C=CN=C4)C3)S1 CC=1[NH1]N=C(Cl)C=1C(=O)N2CCN(C)[C@@H1](CNC(=O)C3=CN=C4SC=CC4=C3)C2 CC#CCCCCNC(=O)[C@H1]1OCC[C@H1]1CNC(=O)[C@H1]2OCC[C@H1]2C(C)C CCC[C@H1]1C[C@@H1]1C2=CSC(NC(=O)[C@H1]3CC4=NN(C)C=C4C(=O)N3)=N2 CN1C=CC(N(C(=O)CSC(F)F)C2=CC=C(C(=O)OC(C)(C)C)C=C2)=C1 CCC(CC)C(=O)N1CCN(C(=O)C=2SC(C)=C(Br)C=2C)[C@@H1](C)[C@H1]1C CC(C)CCCC(=O)NC[C@H1]1COCCN1C(=O)C=2C=CC(=O)N(C3CC3)C=2 CC=C(C)C(=O)N1CC[C@@H1]2C[C@]2(NC(=O)C=3C=C(C)SN=3)CC1 O=C(NCCN(CCOCCO)C(=O)C[C@H1]1CC1(Cl)Cl)C2CC(CCF)C2 C[C@@H1](CN1CCOCC1)N=C2C=CN=C(NC[C@H1]3CCS(=O)(=O)C3(C)C)[NH1]2 C=C[C@@](C)(CC)C(=O)N(CCNC(=O)[C@H1](C(C)C)N1C=NN=C1)C2CC2 CN1CC[C@@H1](C(=O)N2CC[C@](C)(NC(=O)C3=CN=C(S)N3C4CC4)C2)S1(=O)=O CCC(C)(C)N[C@@H1](C)C(=O)N1C[C@H1](N=[N+1]=[N-1])C[C@@H1]1C(=O)N[C@H1](C)C2=NC=CC=N2 CC[C@H1](C)C[C@H1](NC(=O)C=CC=1C=NN(C)C=1)C(=O)NOCC2=CC=C(O)C=C2 CC=1N=C(CO)SC=1C(=O)N(C)[C@H1]2CCCN(C(=O)CC3=CC(C4CC4)=NO3)C2 CC1=CC=CC(CCN=C(NCC2=CC=C3C=CC=CC3=C2)NC[C@@H1]4CCCO4)=N1 CC(C)CCC(=O)N[C@@H1]1CCN(C(=O)C2=NOC3=CC=C(Br)C=C23)C14CCC4 CCCC1=CC(C(=O)NC2[C@@H1](C)CN(C(=O)C3(O)CC(C)(C)C3)C[C@@H1]2C)=NN1C C=CCC1(C(=O)N2CCOC[C@H1](NC(=O)CCCC3=NC=CO3)C2)CCCC1 CN(CC1=CC(C2=CC=CC=C2)=NO1)CC3CCN(S(C)(=O)=O)CC3 CCCN1CC[C@H1](NC(=O)[C@H1]2C[C@@H1](CNC(=O)C3=CC=C(C#N)C(C)=N3)C2)C1 CCC=1ON=C(C(=O)N2C[C@@H1]3[C@@H1](C[C@H1]3NC(=O)C=4C=C5N(C=4)CCCC5)C2)C=1C CONC(=O)C(=O)N[C@H1]1CN(C(=O)C2=CC=NC(C)=N2)[C@]3(CCCOC3)C1 CCCO[C@@H1]1CCCN(C(=O)[C@@H1]2CCCN(C(=O)[C@H1](C)OC(C)=O)CC2)C1 O=C(CCN1C=CC=N1)N[C@@H1]2C[C@H1]3CC[C@@H1]2CN(C(=O)[C@H1]4CC5(CCC5)CO4)C3 CCCCCC(CC)C(=O)N[C@@H1]1CCCC[C@@H1]1NC(=O)C=CC(N(C)CC)C=CC CN1CCC[C@@](F)(C(=O)NC[C@@H1](CO)CNC(=O)C2=C[NH1]C3=NC=CC(Cl)=C23)C1 CN(C)C1=NC(O)=CC(C(=O)N2CC[C@H1](N(C)C(=O)[C@@H1]3CCC(=O)NC3)C2)=N1 C=CC[C@H1]1CCC=C[C@H1]1NC[C@@H1]2CC3=CC(Br)=CC=C3O2 CC1=CC(Cl)=C(Cl)C=C1C(=O)NC[C@H1]2CN(C(=O)C=CCF)C[C@H1]2O C[C@H1]1CCC[C@@H1]1C(=O)N[C@H1]2C[C@@H1](CCNC(=O)C3(O)CC(C)(C)C3)C2 CC(=O)N[C@H1](C(=O)N1CC[C@@](F)(C(=O)N[C@@H1](C)C2CCCCC2)C1)C(C)C CO[C@H1](CNC(=O)[C@@H1](CCF)NC(=O)[C@@H1]1CCC(=O)N(C)C1)C(C)(C)C CC1=CN=CC=C1C(=O)N2CCC[C@H1]2CNC(=O)[C@@H1]3CC[C@H1]([C@@H1]4CCCO4)O3 CC1=C[C@@H1]1C(=O)N2CCCC3(CC(NC(=O)CCC4=CN=CC=N4)C3)C2 CCC(CC)[C@H1](C)NC(=O)C1=CC=C(S(=O)(=O)NCC2=CC=CO2)C=C1 CCOC(=O)C=1N=COC=1CNC(=O)[C@@H1](O)[C@](O)(C2=CC=CC=C2)C(F)(F)F C[C@@H1](CCO)C(=O)N1C[C@@H1](NC(=O)C2=CN=CC(C(C)(C)C)=C2)CC(C)(C)C1 O=C(NCC1=C[NH1]N=C1[C@H1]2CCN(C(=O)CCC(F)F)C2)C3=CC=CC(Cl)=C3Cl CCCSCCC(=O)N(CC)CCN(CC)C(=O)C[C@H1]1CCCO1 CCC1=CC(C)=CC(C(=O)N[C@H1]2C[C@H1](NC(=O)C3=CC(CC(C)C)=C[NH1]3)C2)=C1 C#CC=1C=NN(CC(=O)N[C@H1](CC=2C=C[NH1]N=2)C(=O)N[C@H1](C)CCCC)C=1 CCCCC1(C(=O)N2CC(O)([C@@H1](C)NC(=O)C=3ON=CC=3N)C2)CCC1 CC(C)=CC(=O)N[C@@H1]1C[C@H1](O)[C@@H1](NC(=O)[C@@]2(C)CCO[C@H1](C)C2)C1 CN(CC1(C)CC1)[C@H1](C(=O)NC2=CC=C(F)C=C2)C3CC4(C3)CC(F)(F)C4 CC1=NO[C@@H1](CC(=O)N2[C@H1]3CC[C@@H1]2C[C@@H1](CNC(=O)CC4CC(C)(C)C4)C3)C1 CC(C)[C@@H1](CNC(=O)C[C@@H1]1CCCC(=O)N1)C(=O)NCC=2C=CON=2 O=C([C@H1]1C=CCN1C(=O)CC2=CC=C(O)N=C2)N3CC(OCCF)C3 CN(CC(=O)N[C@@H1]1CCC2=CC=CC=C2C1)[C@H1]3CCC[C@@]3(O)C4=CC=CC=C4 N#CC1=CC=C(C(=O)N2CC[C@H1](NC(=O)C[C@@H1]3CCOC3)[C@@H1](F)C2)C=C1 CC(=O)NC1(CC(=O)NCC2=NC=CC=C2CNC(=O)[C@H1]3C[C@@]3(F)Cl)CC1 C[C@H1]1CCCN2C=C(C3=NC(CCCO)=NN3CC4=CC=CC(C=O)=C4)N=C21 CCCCCCN1N=NN=C1[C@@H1](NCC2=C(F)C=NC=C2F)C3=CC=CC=C3C CC1(C)C[C@@H1]1C(=O)NCC[C@H1]2C[C@H1](NC(=O)[C@H1]3CCC4=NC=NC=C4C3)C2 C=CC1(C(=O)N2CCCC[C@H1](NC(=O)C[C@H1](O)C3CC3)C2)CCC1 COC1=NC=CC(C(=O)N2CC(C)(C)C[C@H1]2CNC(=O)[C@@H1](F)C3(O)CCCC3)=N1 CC(=O)N[C@@H1](C(=O)N1[C@H1]2CC[C@H1]1[C@@H1](C(=O)N3CC[C@H1](CO)[C@H1](F)C3)C2)C(C)C C#CCC1(C(=O)NCCC[C@@H1]2CN(C(=O)C3=CC=C(CF)C=C3)CCO2)CCC1 C=CCCCCCCC(=O)N1CC(C)(CCC(=O)N2CCC(F)(CO)CC2)C1 C=C=C(C)CC(=O)NCCCN1CCN(C(=O)CCOCCC)CC1 COC1=CC=C([C@@H1](C)NS(=O)(=O)C2=CC=C(NCC[C@@H1](C)CCO)C=C2Cl)N=C1 C[C@H1](CCCNC(=O)C1=CN=C(C(C)(C)CF)O1)NC(=O)C2=CC(Cl)=CC=C2N CC1(C2=CN(CCC(=O)N3CCC[C@H1](CCC)C3)N=N2)CCCCCC1 CSCC[C@H1](O)C(=O)N(C)[C@@H1](C)CNC(=O)[C@]1(CC2=CC=C(F)C=C2)CCCO1 C[C@]1(NC(=O)CC2=CC=C(C#N)C=C2)C[C@@H1](C(=O)NC3(C=4N=C[NH1]N=4)CC3)C1 O=C(N[C@H1]1C[C@H1](F)CN(C(=O)CCC2=CC=C(Cl)C=C2F)C1)C=3C=NSN=3 O=C(N[C@@H1]1CCCN(C(=O)C23COCC(C2)C3)C[C@@H1]1F)C4=CC=C5N=C[NH1]C5=N4 C[C@H1](C(=O)NC1=CC=C(N2CCSCC2)C=C1)N3N=C(CO)C(O)=NC3=O COC(=O)[C@@H1]1CC[C@H1]1NC(=O)C2CC3(CCN(C(=O)CC=4C=NOC=4)C3)C2 CC(C)C(=O)N(C)CC(=O)N1CCO[C@H1](CCNC(=O)C[C@H1]2COCCO2)C1 COCCOCCC(=O)N[C@@H1](C)CCC(=O)N[C@@H1]1CC(=O)N(C(C)C)C1 C[C@@H1](CC(=O)NC1=CC=C2C(=C1)OCO2)C(C)(C)NC(=O)C3=CC=NC(O)=C3F N#C[C@]1(C(=O)N2C[C@H1]3[C@@H1](NC(=O)CC4CC5(CC5)C4)CO[C@H1]3C2)CCOC1 CC1(CNC(=O)C2=CC=CC=C2[N+1](=O)[O-1])CN(CC3=N[NH1]C4=CC(Br)=CC=C34)C1 C=C[C@@](C)(O)CC(=O)N[C@H1](C)C1(CNC(=O)C=2OC=NC=2CCC)CC1 O=C(CC1=CC(O)=NC(O)=N1)N2CCC[C@H1]3[C@@H1]2CCCN3C(=O)C4=NOC=C4Cl C[C@H1](CN=C1[NH1]N=CO1)NC(=O)C2=CC=C(CN3CCCCC3)S2 CC1=C(C)C[C@H1](C(=O)N[C@H1]2C[C@H1](F)CN(C(=O)C#C[C@H1]3CCOC3)C2)CC1 C[C@@H1](C(=O)N1CCC[C@]2(CCN2C(=O)C3=CC(Cl)=CN=C3Cl)C1)C4=CC=CC=C4 CCOC(=O)C(C)(C)C(=O)N1CC2CC1(CNC(=O)C=3SC(C)=C(C)C=3C)C2 CO[C@@H1](C)C(=O)N[C@H1](CNC(=O)C=C[C@H1]1CCCO1)C(C)(C)C CN(CC(=O)NCC1[C@@H1]2CN(C(=O)[C@@]34CCC[C@@H1](C3)NS(=O)(=O)C4)C[C@@H1]12)C5CC5 CCN1CC[C@H1]2CC[C@@H1](C1)N2C3=CC(N[C@@H1]4CCCC5(CC4)CC5)=NC=N3 C=CCCCC(=O)N1C[C@H1](N2C=CN=N2)[C@H1](NC(=O)C3=COC(C(N)=O)=C3)C1 CC1=CC=C(Cl)C([C@H1](NC2CN(S(C)(=O)=O)C2)C3=NN=NN3C4CC4)=C1 CCCC1=CC=CC=C1C(=O)N2CC[C@@H1]([C@@H1](C)NC(=O)C3=CSC=C3OC)C2 CC(C)(C)C=1OC=NC=1C(=O)N[C@@H1]2CCN(C(=O)C3CCC(F)(F)CC3)C2 C#CC1=CN(C)N=C1C(=O)N[C@H1](C(=O)N[C@H1](C)CCC2CC2)C3(C)CC3 CC=1[NH1]C2=CC=CC=C2C=1C(=O)OCC3=C(F)C=C(I)C=C3F C#CCC[C@H1]1CCCN1[C@H1](C(=O)NCC2=CC=CC=C2Br)C3=CC=C(F)C=C3Br O=C(N[C@@H1]1[C@H1]2C[C@@H1]3[C@H1]1[C@@H1]3[C@@H1]2C(=O)NCC4=NN=NN4C5CC5)[C@H1](F)C6CCCCC6 O=S(=O)(C1=CC=C(Br)C=C1F)N2C[C@H1](C=3C=CSC=3)[C@@H1](CO)C2 COC1=NSC=C1C(=O)N[C@@H1](C)C2(CNC(=O)[C@@H1](C(C)C)C3CCC3)CC2 C=CCCCC(C)(C)C(=O)NCC=1OC=NC=1C(=O)N(C)[C@H1]2CCOC(C)(C)C2 C=C(C)CNC(=O)[C@@H1](C=1C=C(C2CC2)ON=1)N3CCCCC[C@H1]3C4=CC=CN=C4 CC1=CC(C(=O)N[C@]23C[C@H1]2CN(C(=O)C4=CC=C(C#N)C(Cl)=C4)C3)=C(O)N=C1C CC1(C)COC[C@@H1]1C(=O)N2CC3(CC(NC(=O)C4=CC=NN4CC5CCC5)C3)C2 CC[C@H1](C(=O)N1CC(CNC(=O)C=2SC(C)=NC=2C)(OC)C1)N3C=NC=N3 CC1=CC(F)=C(C(=O)NCC2=CC=C3OC=NC3=C2)C=C1F CCCC(=O)NCC(=O)N1CCC2(CC1)C[C@H1]2NC(=O)C3=CC=C(C(C)C)C=C3 CC(C)N1N=CN=C1C(=O)NC[C@H1](C)CN(C)C(=O)[C@@H1]2C[C@H1](C)O[C@@H1]2C COC(=O)C=CC1=CC=C(NC(=O)N[C@H1]2CCN(C(C)C)C2=O)C=C1F CC(C)[C@@H1]1C[C@H1]1C(=O)N2CC[C@H1]3CCC[C@@H1](C2)N3C(=O)C4=CC=C(O)C=C4[N+1](=O)[O-1] C[C@]1(C#CC(=O)N2CC(O)(CNC(=O)[C@@H1](O)C3=CC(F)=CC(F)=C3)C2)CCCO1 CCN(C(=O)[C@H1](C)C1=CC=CC=C1Cl)[C@@H1]2CCN(C(=O)[C@H1](C)CC(N)=O)C2 FC1=CC=C(CNC(=NC[C@@H1]2CCCC3(CC3)C2)N4CCCCC4)C=C1 CCN1C(COC(=O)CC2=CN=C3N2CCC[C@H1]3C)=NC4=CC=CC=C41 CCSCCCN[C@@H1](C1=NN=NN1C2=CC=CC=C2)[C@H1]3C[C@@H1]4C[C@@H1]4C3 C=CC[C@H1](C)C(=O)NCCC1(OC)CN(C(=O)[C@@H1](C)C(F)F)C1 N#CC1(C(=O)N2CC(C[C@@H1](F)C(=O)N[C@H1]3CCCN4N=CC=C43)C2)CC=CC1 CC(=O)C1=NC=C(C(=O)N(C)[C@@H1](C)CCNC(=O)CC=2N=C(C)SC=2Cl)S1 CCC[C@H1](C#N)C(=O)N[C@@H1](CCN(C)C(=O)C(F)(F)CC)C(C)(C)C CCN1N=CC=C1C(=O)N2CCCCC[C@H1]2CNC(=O)[C@@H1]3CCC4=N[NH1]C=C4C3 CC[C@@H1](CNC(=O)[C@@H1](SC)C1CC1)NC(=O)C[C@@H1]2NC(=O)NC2=O C#CCCC(=O)N1C[C@@H1](C(=O)O)C2(CN(C(=O)C3=CC(C)=CC=C3OC)C2)C1 CC(C)(C)[C@@H1](C(=O)N[C@@H1]1CC[C@@H1](NC(=O)C2CCC=CCC2)C1)N3C=CN=C3 COCCOCC=CC(=O)N1CC=C(C(=O)N[C@H1](C)C2CCCC2)CC1 CC[C@@H1](C(=O)NC1([C@@H1]2CCCN(C(=O)C3=CC=NC=N3)C2)CC1)C(C)C CN(CCCCC(=O)NCCC[C@@H1]1CC1(Cl)Cl)C(=O)[C@H1](F)C2CCOCC2 C#CCN(CCC(=O)NCC[C@@H1](O)C1CC1)C(=O)[C@H1]2CC(=O)CS2 C=C[C@@](C)(CC)C(=O)N1CC[C@@H1](NC(=O)C2=CC=CC(C(=O)C3=CC=CO3)=C2)C1 CN=C1C=CC(C(=O)N2[C@@H1](C(=O)NC[C@@H1]3CCCO3)C[C@@H1]4C[C@H1]42)=C[NH1]1 CC1=NC(CO)=NC=C1C(=O)NCC2(O)CN(C(=O)C#CC(C)(C)C)C2 CC[C@@H1]1C[C@H1](CC(=O)N2CC([C@@H1](C)NC(=O)C3=CC=CC=C3COC)C2)CCO1 CCN1C[C@@H1](NC(=O)C2=COC(CC3=CC=CS3)=N2)CCC1=O CCC(=O)N1CCC[C@H1](C(=O)N[C@H1](CO)CCCCNC(=O)[C@H1]2C[C@@H1](OC)C2)C1 CC(C)(C)[C@@H1](CNC(=O)C1=CC=C2C(Br)=N[NH1]C2=C1)NC(=O)C3=CN=CC=N3 CC1=NC=C(C(=O)NC2C[C@@H1](CNC(=O)CN3C=CC(=O)C=C3C)C24CC4)N1C CCC1=CC(F)=CC=C1C(=O)N(C)[C@H1]2CC[C@@H1](NC(=O)C3[C@H1]4COC[C@H1]34)CC2 CCC(CC)(C(=O)O)C(=O)N1CC2(CC(NCC3=CN=CC=N3)C2)C1 CCC(CC)CCC(=O)N[C@H1](C)CCCNC(=O)C1=COC(C)=C1 CC1=CN=CC(C(=O)N2CCCC[C@H1]2C(=O)N(C)C3CSC3)=N1 CC(C)CCCC(=O)N[C@]1(CNC(=O)C=2C=C(CO)[NH1]N=2)CCOC1 C=C[C@](C)(CCOC)C(=O)N1CC2(CN(C(=O)[C@H1]3CC(=O)N([C@H1](C)CC)C3)C2)C1 CCC[C@@H1](OC)C(=O)N1C[C@H1]2C[C@@]2(C(=O)NC[C@]3(C)CCCOC3)C1 C[C@@]1(CNC(=O)[C@@H1]2CC[C@H1](C(N)=O)C2)COCCN(C(=O)C3=CC=NC=C3Cl)C1 CN(CC1(NC(=O)[C@@H1]2C[C@H1]2OC(C)(C)C)CC1)C(=O)CC3=CSC=N3 CC=1C=C(NC(=O)[C@@H1](C)NC[C@H1]2CCCCN2S(=O)(=O)C3=CC=CC=C3)N(C)N=1 C[C@@H1](NC1=CC(NCCC2=NC=CC(C(F)F)=N2)=NC=N1)[C@H1]3CCCO3 CC1=CC(C(=O)NC2(CC(=O)N3CCC(N4CCOCC4)CC3)CC2)=CC=C1O C[C@]1(C(=O)N2C[C@H1](NC(=O)CC3=CC(O)=CC(Br)=C3)C4(CC4)C2)CCNC1 COC1=CC=CC=C1C(=O)N[C@]23CCC[C@@]2(F)CN(C(=O)COCP(C)(C)=O)C3 CCC=1SC=CC=1C(=O)NC[C@H1]2C[C@@H1]2NC(=O)CCNC(=O)C3=CC=CO3 CC[C@H1](C(=O)NC[C@H1]1[C@@H1]2CN(C(=O)C=3C(C(C)C)=N[NH1]C=3C)C[C@H1]12)C(=O)OC CC[C@H1](CC(C)C)C(=O)N[C@H1]1CCCN(C(=O)CC2=CC=C(F)C=N2)C1 CC(C)[C@@H1](O)C(=O)N1CCOC[C@H1]1CCNC(=O)CSC2=NC3=CC=CC=C3[NH1]2 CN1C(=O)CCC[C@@H1]1C(=O)N2CC(O)(CCNC(=O)C[C@@H1]3C[C@H1]4CC[C@H1]3O4)C2 COC[C@]1(O)CCCN([C@H1](C(=O)NCC(F)F)C2=CC=C(CO)O2)CC1 COC[C@H1](C(=O)N[C@]1(C(=O)N[C@H1]2CC(=O)N(C(C)C)C2)CCC[C@@H1]1C)N(C)C CC(C)[C@@H1](C)[C@H1](CNC(=O)C1=CC=C2N=C(O)[NH1]C2=C1)NC(=O)C3(O)CCC3 CC=1ON=C(C2CC2)C=1C(=O)N3CCN4CCN(C(=O)[C@H1](F)C(C)C)C[C@@H1]4C3 CC[C@]1(C(=O)NC[C@H1]2C[C@@H1](C(=O)N3CC(O)(C(F)F)C3)C2)CCC[C@@H1]1O CCC=1N=COC=1C(=O)NC[C@H1]2C[C@@H1](NC(=O)[C@]3(C#N)CC34CCOCC4)C2 COC(=O)[C@H1](C)CC(=O)N1C[C@H1]2C(CNC(=O)C3=C[NH1]C=C(Br)C3=O)[C@@H1]2C1 CC1=NC=CC(C(=O)N(C)[C@H1]2CCC[C@@H1](NC(=O)C=3OC(C)=NC=3C)C2)=C1Cl CC1=CN=C(COCC(=O)N2[C@H1]3CC[C@H1]2CN(C(=O)C4=CC=NN=C4)C3)O1 CC[C@H1](COC)C(=O)NC[C@H1](O)C(=O)NC(C)(C)[C@H1](O)C(F)F CC1=NOC(N)=C1C(=O)N2C[C@H1](CCNC(=O)C3=CC=C(N(C)C)N=C3)O[C@H1](C)C2 CCC=1C(C(=O)N[C@@H1]2CCN(C(=O)[C@]3(C)CNC(=O)N3)C[C@H1]2F)=CSC=1C CCN1C=CN=C1CNC(=O)[C@@]2(C)C[C@@H1](O)CN2C(=O)C3CCS(=O)CC3 CCCCC[C@H1](CC)C(=O)N[C@@H1](CCC)CCCNC(=O)C=1C=COC=1CC CC(C)CC1=CC=C(CC(=O)N[C@@H1]2CN(C(=O)[C@]3(O)CCSC3)C[C@@H1]2C)C=C1 COC(=O)CNC(=O)[C@H1]1CC[C@H1]1CNC(=O)C2=CC(OC)=NS2 COC[C@@](C)(CCO)NC(=O)CCCN(C)C(=O)[C@@H1]1CCC[C@H1]1OC CNS(=O)(=O)CCC(=O)N1C[C@H1](C)CN(C(=O)/C(C)=C/C(C)(C)C)C[C@@H1]1C CC(C)CCCOCC(=O)N1C[C@@H1](NC(=O)CC2=NC=CN2C)C[C@@H1](F)C1 CC1=C(F)C=CC=C1C(=O)NC[C@@H1]2CCN(C(=O)C=CC3=CC(F)=CC(F)=C3)C2 CC1=CC=NC(N2CCC[C@@H1]2C(C)(C)NC(=O)C3=NOC4=C3COCC4)=N1 CSCC[C@@H1](O)CC(=O)N1CCC[C@]2(C1)CN(C(=O)C3=CC(C)=NN3C)CCO2 CSC1(CNC(=NCC2CC2)N(C)CC(=O)NC3=CC=C(Cl)C(F)=C3)CC1 CC=1OC(C(C)C)=CC=1C(=O)N[C@@H1]2C[C@@H1]3CN(C(=O)CN(C)C)C[C@H1]32 CC(C)(C)OC(=O)N1C[C@H1]2[C@H1](CNC(=O)COC3=CC=C(C(=O)O)C=C3)[C@H1]2C1 C[C@H1](NC(=O)C1=CC=C2C=C[NH1]C2=N1)C3CCN(C(=O)[C@H1]4CC[C@H1](F)C4)CC3 CC=1C=C(Br)OC=1C(=O)N2C[C@@H1](O)[C@H1](NC(=O)C3=CC=CS3)C2 CC[C@H1](CCC(=O)N1[C@H1]2CC[C@@H1]1C[C@@H1](NC(=O)CN3N=CC(Cl)=C3C)C2)OC CO[C@H1](C(=O)NC[C@H1](F)CNC(=O)C(C)(C)S(C)(=O)=O)CCN1C=CN=C1 O=C(NCC1=CSC(O)=N1)[C@H1]2N(C(=O)CCCCCF)CC23CCCC3 N#CC=1C=CC(=N[C@H1](CNC(=O)C(=O)C(F)(F)F)C2CC2)[NH1]N=1 C#CCO[C@@H1](C)C(=O)N[C@H1]1CCN(C(=O)CN2C=NC(Br)=C2)[C@H1]1C CN1C[C@@H1](C(=O)NCC2=NC(CNC(=O)C3=CN(C4CC4)N=N3)=CS2)CCC1=O CC[C@@](C)(CN(C)C(=O)[C@]12CCC[C@H1]1CN(C(=O)C3=COCCC3)C2)OC CC(C)(CC(=O)NC1(C)CN(C(=O)CN2N=CC3=NC=CC=C32)C1)C4=CC=CS4 CC1=CC=C(C(=O)N(C)C[C@H1](C)NC(=O)C2=CC(C=3C=NN(C)C=3)=NO2)C(C)=C1 CCOCCO[C@@H1](C)C(=O)NC[C@@]1(F)CCCN(C(=O)CS(=O)(=O)NC)C1 CS(=O)(=O)[C@@H1]1CN(C(=O)C(N)=O)C[C@H1]1NC(=O)[C@]23C[C@H1]2CN(CC4=CC=CC=C4)C3 C=C1CC(CNC(=O)CC2=CC=CN=C2)(C(=O)NCC3[C@@H1]4CCC[C@@H1]34)C1 CN(C)C(=O)C=CC(=O)N(C)[C@H1]1CCN(C(=O)CC2(C)CCOCC2)C1 CC(C)C(=O)N1CC[C@@H1](NC(=O)CCCN=C2[NH1]C3=CC=CC=C3S2)[C@@H1](O)C1 CCN1C=C([N+1](=O)[O-1])C(C(=O)N2CC3(CCN3C(=O)[C@H1]4CCCC[C@@H1]4F)C2)=N1 O=C(C1CCCCCC1)N2CCC3(CCCN(CC4=CN=C(Cl)S4)C3)CC2 CC1=NN=C(SCCNC(=O)[C@]23CCN(C(=O)[C@@H1]4CCCS4)C[C@H1]2C3=O)S1 C#CCN(CC1=CC=C(I)C=C1)C[C@@H1](O)C2=CC=CC=C2 CC=C(CC)C(=O)N1CCN(C(=O)C=2C=CC3=N[NH1]C=C3C=2C)C[C@@](C)(F)C1 O=C(N1C[C@@H1]2CC[C@H1](C1)N2C(=O)C3(F)CCC3)C4=COC5=CC=CC(O)=C45 O=C(NCCC=1C=C[NH1]N=1)[C@H1]2CC=C[C@H1](N3C=C(C4=CC=C(Cl)C=C4F)N=N3)C2 CC1=CSC(C[C@@H1]2CCCN(C(=O)[C@@H1]3C[C@H1](C4=CC=CC=C4)CN3)C2)=N1 CSC1=CC=CC(C2=NC(COC(C)=O)=NN2CCCCO)=C1Cl N=C1N=CC(C(=O)N2C[C@H1]3C=C[C@H1]2[C@H1](C(=O)N4C[C@@H1]5C[C@@H1]5[C@H1]6C[C@@H1]64)C3)=C[NH1]1 COC=1C=CC(=NC(=O)C(=O)NC[C@@H1](C)CN2CCOCC2)[NH1]N=1 CCS(=O)(=O)NCC(=O)N1CCN(C(=O)C=2N=N[NH1]C=2Cl)C[C@H1]1C=3C=N[NH1]C=3 CCC[C@H1](NC(=O)[C@@H1]1[C@H1]2CC[C@@H1](C2)[C@@H1]1C)[C@@H1](O)C(=O)NCCN3CCCOCC3 CC1=CC=C(NC=C(C(=O)NC[C@@H1]2C[C@H1]3CNC[C@H1]32)C(C)=N)C=C1 CC1=NN=C(NCCCCCCNC(=O)C(F)(F)C2=CC=C(F)C=C2)S1 C[C@@H1](CC(=O)N1C[C@H1]2COC[C@@H1](C1)N2CC3=CC=CC=C3)C4=CC=CO4 C=CC[C@@H1](C1=NC(C2=NC(C(F)(F)F)=CS2)=NO1)C(C)C COC1(CC(=O)NCC2=CC=C3C(=C2)CC[C@@H1]3NC(=O)CCCC(N)=O)CCC1 CC1=NC2=CC=C(C(=O)NC3=CC=C(C#N)N=C3)C=C2S1 CC(C)(CCCO)NC(=O)C[C@@H1](O)CNC(=O)C=1C=CSC=1Cl COCCCC(C)(C)C(=O)NC[C@H1]1C[C@@H1]1NC(=O)C2=CSN=C2Cl CC1=COC(C2CC2)=C1C(=O)N3C[C@@]4(NC(=O)[C@@H1](C)NC(N)=O)CC[C@H1]3C4 CO[C@H1](C)CC(=O)N1C[C@@H1](NC(=O)C2=CC(N)=CC=N2)CC1(C)C CCC[C@H1](C)C(=O)N1CCC2(CC[C@H1]2NC(=O)C3=CC(Cl)=CC=C3[N+1](=O)[O-1])CC1 CN1N=CC(CN(C2=CC=C(S(N)(=O)=O)C=N2)[C@H1]3C[C@H1]4C[C@H1]3CN4)=C1Cl CCOCCO[C@H1](C)C(=O)N1CC[C@H1](CNC(=O)C=2C=C(C(C)=O)ON=2)[C@H1](O)C1 C[C@@H1](NC1=CC=C(S(=O)(=O)NCCOC2CCCCC2)C(C3=CC=CS3)=C1)C4CC4 CSC[C@@H1]1CCCN1C(=O)NCC=2N=COC=2CCNC(=O)OC(C)(C)C CCC1=NC=C(CNC2=NC=NC(NCC3=CC=CC4=CC=CN=C34)=C2CC)S1 CCCC(CCC)C(=O)NCCCCCN(C)C(=O)[C@@H1]1CCC[C@@H1]1C2=CC=CS2 C=C(Cl)CCCNC(=O)[C@H1](CC1=CC=CO1)NC(=O)[C@H1]2C=CCS2 C#CC[C@@H1](CC(F)F)C(=O)NCCCNC(=O)[C@@H1](C)C1=CN=CN=C1 CCOC1=CC(CN2CCC[C@H1]2C(=O)N(C)CC)=CC=C1OCC(=O)OC COCC[C@@H1]1C[C@H1]1C(=O)N2C[C@H1](CC3=CC=CC=C3)[C@H1](NC(=O)CCC(N)=O)C2 O=C([C@@H1]1C[C@@H1](O)CN1CCCCl)N2CCCC23CCCC3 CC1=CC=C(O)C=C1C(=O)N[C@H1](C)C(=O)N[C@H1]2C[C@H1]3CCCCC[C@@H1]23 CC1=CC=C(F)C(C(=O)N[C@H1](C)[C@@H1](CO)NC(=O)C2=CC=C3N=C[NH1]C3=C2F)=C1 CC[C@@H1](C)[C@H1]1CCCCN1S(=O)(=O)CC2=CC=C(Br)C=N2 CC(CCN(C)C)NC(=O)C(=O)NC1=CC=C(F)C(N2C(=O)CN(C)C2=O)=C1 CC=1OC=CC=1CNC(=O)CCOCCCNC(=O)CN2C[C@H1]3C[C@H1]3C2 CCOC1=CC=C(C[C@@H1](C)C(=O)NC2(CO)CN(C(=O)CCCF)C2)C=C1 CO[C@H1]1C[C@H1](C(=O)N2CCN(C(=O)CC3=CC=CC(C#N)=C3)C[C@@H1]2CCO)C1 CC1=CC=C(C#N)C(N2CC(CNC(=O)[C@H1](C)N3C=CN=C3C)(C(N)=O)C2)=N1 O=C(C1=CC=NC=C1Cl)N2C[C@H1]3[C@@H1]4CC[C@@H1](CN4C(=O)[C@@H1]5C[C@]5(F)Cl)[C@H1]3C2 C[C@@H1]1CN(C(=O)C2=COCCC2)C[C@@H1]1NC(=O)CC3=CC=CN=C3O CC[C@@H1](O)CC(=O)N1CC[C@@H1]2CN(C3=CC=NC(Br)=N3)C[C@@H1]21 COC(=O)C=1N=C(NC(=O)[C@H1]2C[C@]23CCN(S(=O)(=O)CC4CCC4)C3)SC=1Br CCC(=O)N[C@H1](C)C(=O)N(C)CCN(C(=O)C=1SC(SC)=CC=1C)C(C)C CC1=C[NH1]C(C#N)=NC1=NC[C@@H1]2CC(C)(C)CC[C@H1]2NC(=O)[C@H1](C)CO O=C(NCC[C@H1]1CCCCN1C(=O)C[C@@H1]2C=CCCC2)C(=O)NCC(F)F CO[C@@H1](C(=O)N[C@@H1]1CCN(C(=O)C=C2C3CC4CC(C3)CC2C4)C1)[C@@H1]5CCOC5 CCCN1N=NN=C1[C@H1](N[C@@H1](C)COCC2CC2)C3=C[NH1]C(=O)C4=CC=NN34 CCN1N=C(C(=O)N[C@H1](CCCOC)C(=O)N(C)CCCC(C)(F)F)C=C1C C=CC[C@H1]1CCCN(C(=O)[C@@H1](CCC(C)C)NC(=O)C(=O)CCC(C)C)C1 O=C(NC1(CNC(=O)[C@@H1]2C[C@H1]2C3=C(Cl)C=CC=C3Cl)CCC1)C4=CN=C(S)[NH1]4 C[C@H1](O)CN(CCNC(=O)C=1ON=C2C=1CCCC2)C(=O)C[C@@H1]3CC=CCN3C COCCCN1C(N2CC(=O)N(C)C2)=NN=C1C=3SC(C)=NC=3C C[C@H1](C(=O)N[C@@H1]1CC[C@H1]2CN(C(=O)C3(C(N)=O)CCC3)CC[C@@H1]2C1)C4=CC=CO4 CC(C)C[C@@H1](CNC(=O)C1=CCC(C)(C)CC1)NC(=O)[C@H1](C)C#N CS(=O)(=O)CC(=O)NC1(CNC(=O)C=2C=NC3=NC=CN3C=2)CCCCCC1 CC1=CC=C(CN=C2[NH1]C(=NC[C@@H1](C)OC(F)F)[NH1]C3=CC=CN=C23)N=N1 CN(C(=O)[C@H1](O)CC(N)=O)[C@@H1]1CCCN(C(=O)CCC2=CC=C(Cl)S2)C1 C[C@@H1](CN(C)C(=O)C1=C(Cl)CCCC1)N(C)C(=O)C=2C=NN(CCO)C=2 CCN(C(=O)[C@@H1]1CC(=O)CCO1)[C@@H1](C)C(=O)N[C@H1](C)C=2C=NN(C)C=2 O=C([C@H1]1CC[C@H1](C(F)(F)F)C1)N2C[C@H1](O)[C@H1](NC(=O)C34CCC(CC3)C4)C2 CC1=CC=CC(OCC(=O)N[C@H1]2CCCN(C(=O)C3(Br)CC3)C2)=C1C CC1=NN(C)C(Cl)=C1C(=O)N[C@H1]2CCC[C@H1]2CNC(=O)CCCN(C)C(C)C C[C@@H1]1CCO[C@@H1]1C2=NC([C@H1]3CCC4=CC=CC=C4C3)=NN2C5=CC=NC(Cl)=C5 N#CC1(CC(=O)N(CCCNC(=O)[C@H1]2CC[C@H1](C3CC3)C2)C4CC4)CCOCC1 CC1=NC(O)=NC(C)=C1CCC(=O)NCCC(C)(C)NC(=O)[C@H1]2C[C@@]23CCOC3 C#CCN1C(C)=CC(C(=O)N(CCC)[C@@H1]2CCN(C(=O)/C(Cl)=C/Cl)C2)=C1C COC(OC)C1=CC=C(CNC(=O)C(=O)NC[C@H1](O)COC2=CC=CC=C2Br)C1 C[C@H1](NC(=O)C=CC1=CN=CN1C)[C@@H1]2CCN(C(=O)CCOC3CC3)C2 CC=C[C@H1](O)C(=O)NC[C@H1]1CCC2(CCN(C(=O)C3=CC=CO3)CC2)CO1 CCN(CC(=O)N[C@@H1]1C[C@@H1]1CNC(=O)CCC2=CC=NC=N2)C3CC3 CC[S@@](=O)CC(=O)N1CCC[C@@]2(CCCN2C(=O)C3=CN=C(C4CC4)S3)C1 O=C(CC1=CN=CS1)NC[C@@H1]2CC[C@H1]2NC(=O)C[S@](=O)C(F)(F)F CC1CC(C(=O)N2CCO[C@@H1](C3CN(C(=O)CC4=C[NH1]N=C4C)C3)C2)C1 CO[C@](C)(C(=O)N[C@H1]1CCN(C(=O)C2=CC3=CC=CC(F)=C3O2)C1)C(C)C CN1CCC(OC(=O)C2=CC=CC=C2C3=NN=C(O)O3)CC1 C#CCCCCNC(=O)C1=CSC=C1C2=CC=C(N(C)C)N=C2 C=CCC(CC=C)C(=O)N1CCCN(C(=O)C2=CC=C([C@@H1]3CCOC3)S2)C[C@H1]1C CC=1N=CSC=1CC(=O)NC[C@@H1](C(F)F)N2CCN(C(=O)/C=C/C(C)(C)C)CC2 C1OC2CCC(NC(=O)C3=CC(Br)=C(F)C=C3F)(CN2C)CC1 CC1=NC(SCC(=O)NC[C@]2(C)CC[C@H1](NC(=O)CC3(C)CC3)C2)=N[NH1]1 COC(=O)C1=CC=C(C(=O)N2CC(F)(CNC(=O)[C@@H1](O)C3=CC=CC(C)=C3)C2)[NH1]1 CC1=CC(CNC(=O)[C@H1](CCOCCO)NC(=O)CCCF)=CO1 C#CCN(C(=O)CC(C)(C)CCC)[C@@H1]1CCN(C(=O)[C@H1]2CC3=CC=CC=C32)C1 CC1=CN=NC(C(=O)NC[C@@H1](C)N(C)C(=O)CCCCCS(N)(=O)=O)=C1 C[C@H1](C(=O)N1CCC[C@@]1(C)CNC(=O)C2=CSC(C(F)(F)F)=N2)P(C)(C)=O CN(C)C[C@@H1](O)CN(C)C(=O)C[C@@H1]1CCCN(C(=O)C2(C)SCCCS2)C1 CC(C)(C)OC(=O)N1CC=CC[C@]1(C)C(=O)N2CCC(F)(F)[C@@H1](CO)C2 C=CCC[C@@H1](CC(C)C)C(=O)NC[C@H1]1C[C@H1]2CC[C@H1]1N2C(=O)CCSCCC O=C(CC[C@@H1]1C[C@H1]1CC2CC2)N[C@@H1]3CCCN(C(=O)C4=CC(C5CC5)=NC=N4)C3 O=C(NC1CCN(C(=O)CN2CCCC[C@@H1](O)C2=O)CC1)C3=C(Cl)CCOC3 CS[C@H1](C(=O)N1CC[C@]2(C=C([C@H1](O)C3=CC=C(F)C=C3)C2)C1)C4=CC=CC(Cl)=C4 C[C@@H1]1SCCC[C@@H1]1C(=O)NCC2=CC=CC(CNC(=O)CC(C)(C)C)=C2 NC1=CC=C(C(=O)N2C[C@@H1](O)[C@H1](NC(=O)[C@@H1]3C[C@@H1]4CCCC[C@@H1]43)C2)C=C1N C[C@H1](NC(=O)N(C)CC1=CC=C(O)C=C1)C2(C3=CC=CC=C3)CC2 CC(C)(N)CCNC(=O)[C@H1]1CC[C@@H1](N2C=C(COCCCO)N=N2)C1 C[C@H1]1C[C@@H1](C(=O)O)CN(C(=O)COCC2=CC=C(Cl)C(C(F)(F)F)=C2)C1 CC1=CN(CC(=O)NC2CN(C(=O)C=3C(C)=NN(C(C)C)C=3C)C2)N=C1C(F)F CS[C@@H1](C)CNC(=O)C[C@@H1]1CCN(C(=O)C2=CN=CC=C2C)C1(C)C CC[C@@]1(C(=O)NC=2C=NN(C)C=2C)CCCN1C(=O)CCCN3C=CN=C3 C=CCN1C=CC=C1C(=O)N[C@@H1]2C[C@H1](CNC(=O)C3=CC(Br)=CO3)C24CCC4 C=CCC1(C(=O)N[C@H1]2C[C@@H1](CNC(=O)CC[S@@](C)=O)C2)CCOCC1 C=CC1(O)CN(C(=O)CO[C@H1]2CCN(C(=O)C3CS(=O)(=O)C3)C2)C1 CC=1N=NSC=1CN=C2C=C(NCCOC3=CC=CC=C3C(=O)O)N=C[NH1]2 C[C@@H1](CC(F)(F)F)N(C)C(=O)C1=CCN(C(=O)[C@H1]2CC[C@H1]3C[C@H1]32)C1 CC1(C)CN(C(=O)C23COC(CF)(C2)C3)C[C@H1](CNC(=O)[C@@H1]4CCSC4)O1 N#C[C@H1]1CC[C@H1](C(=O)N[C@H1](C2=NC=CS2)C3CC3)C1 CC1=CC=NC(C(=O)NCC2(C)CC(NC(=O)[C@@H1](O)CC(F)F)C2)=N1 COC1=CC=C(C(=O)N2CC[C@@H1](NC(=O)C3CCN(C(N)=O)CC3)C[C@H1]2C)N=C1 CC1=C(Cl)C=CC=C1NC(=O)CCC(C)(C)NC(=O)C2=CN=CS2 COC[C@@H1](C)CCS(=O)(=O)N1CCC2(CCN(C)CC2)CC1 O=C(CCC1=CC=C2C(=C1)COCC2)NC[C@@H1]3CCN(C(=O)C4=CC=NS4)C3 CN1C=C(NCC2=CC(O)=CC(Cl)=C2)N=C1C(=O)N[C@@H1]3CCS(=O)(=O)C3 CC1=NC=C(Cl)C=C1CC(=O)N2C[C@H1](NC(=O)[C@H1](C)C(C)(C)C)C3(CCCC3)C2 C#CC1(NC(=O)C(C)(C)CCCNC(=O)[C@]23CCCC[C@H1]2C3)CC1 CC1=NC=CN1CCCC(=O)NC[C@]23CN(C(=O)[C@H1]4CCCN(C)C4)C[C@H1]2CCO3 CSCC(=O)N1CCC(C[C@H1](C)NC(=O)[C@@H1]2CC[C@H1]2N3C=CC=N3)CC1 CN(CC1=CC(Br)=CC(Br)=C1)[C@@H1](C(=O)O)C2=CC=C(C#N)C=C2 COC(=O)[C@]1(OC)CCN(C(=O)C=C2CCN(C3=CC=CC=C3)CC2)C[C@H1]1O O=C(N[C@H1](CO)C1CCN(C(=O)COCC(F)F)CC1)[C@@H1]2CC2(Cl)Cl CO[C@@H1](CNC(=O)C1=N[NH1]C2=C1CN(C(=O)CC[C@H1]3CCCO3)C2)C4CCCC4 CC1=CC(C(=O)N[C@H1]2C3C[C@H1]4[C@@H1](C3)C24C(=O)NCCC5CC(C)C5)=CN1C CC[C@H1](C)[C@H1](O)[C@@H1](C)C(=O)N1CC[C@@](C)(CNC(=O)C=2C=C(Cl)N(C)N=2)C1 C[C@@](O)(CC(=O)N1CC(CCNC(=O)[C@](C)(O)C2CCC2)C1)C3=CC=CC=C3 CO[C@@H1](C(=O)N1C[C@H1]2CC(F)(F)CC[C@@]2(NC(=O)C=3OC=CC=3Cl)C1)C4CCC4 CCC1=CC=CC(N2C=C(C3(NC(=O)CC4CC(=O)C4)CCC3)N=N2)=C1 CCOC(=O)[C@H1](OC)C(=O)NC[C@@H1]1CCN(C(=O)[C@H1]2CC[C@@H1](C)O2)C[C@H1]1O CC[C@](C)(CNC(=O)[C@@H1](C)CN1C=CN=C1)C(=O)NC[C@H1]2C=CCOC2 C#C[C@H1]1CC[C@H1](CNC(=O)CC2=CC=C(N3C=C(C4(O)CSC4)N=N3)C=C2)CC1 COC(=O)[C@@]1(C(=O)NC/C=C/CC(=O)N(C)CC2=CN=CC=C2C)C[C@H1]1C C[C@H1](OCCN(C)C)C(=O)N(C)CC1(O)CN(C(=O)C2=CC=3SC=CC=3N2C)C1 CC=1C=C(C)N(CCNC(=O)[C@@H1]2CC[C@H1](NC(=O)[C@H1]3CCC(=O)NC3)C2)N=1 C=CCOCC(=O)N(CCCN(C)C)CCNC(=O)CC1(C#N)CCC1 CC1(C)C[C@H1](CO)CN([C@@H1](C(=O)NCCC2CC2)C=3SC=NC=3Cl)C1 CC(=O)OCC(=O)NC[C@@H1](C)NC(=O)C[C@@H1]1SC2=CC=CC=C2NC1=O C[C@@H1]1C[C@H1]1CNC(=O)C23CCC(NC(=O)[C@@H1]4CCNC4=O)(CC2)C3 CC1=CN=C(C(=O)N2CCN(C(=O)C=3C=C[NH1]N=3)[C@H1](C4=CC=CN=C4)C2)C=N1 CCC1(NC(=O)C=CBr)CN(C(=O)[C@@H1]2CC3=CC=CC=C32)C1 C[C@H1]1CCCC[C@@H1]1CC(=O)OCC2=CC=C(C3(C(F)(F)F)N=N3)C=C2 C[C@H1](CC1CN(C(=O)C23C4C5C2C6C3C4C56CO)C1)NC(=O)C7=NO[C@H1](C)C7 CS[C@H1](C)C(=O)N1CC[C@H1](CO)[C@@H1](NC(=O)COCC=CC2=CC=CC=C2)CC1 CC1=CC=C2C(=C1)C=C(C(=O)N3C[C@@H1](NC(=O)[C@H1]4CC4(Cl)Cl)C5(CC5)C3)CO2 CCC1=CC=C([C@H1](NCC2=CSC=C2Cl)C3=NN=NN3C4CC4)N=C1 NC(=O)C[C@@H1](O)C(=O)NC[C@H1](NC(=O)C1=NN(C(F)F)C=C1Cl)C2CCC2 COCC1=CC(C(=O)NC[C@@H1]2C[C@H1]2CNC(=O)/C=C/C3=CC=C(C)C=C3C)=CS1 CC(C)C1=NC(=NCC2(O)CCN(C(=O)[C@H1]3C[C@@H1](C4=CC=CC=C4)C3)CC2)S[NH1]1 CSCCC(=O)NC[C@@H1]1CCC[C@H1]1NC(=O)CC2=CC=CC(CC#N)=C2 O=C(C1=CC=C2C(=C1)CCC2)N3CC[C@@H1](C4CCN(C5=CC=NC(Cl)=N5)CC4)C3 C=C(C)CCC(=O)NC[C@@]12CC[C@@](NC(=O)[C@H1]3CCC4=CN=C(C)N4C3)(CO1)C2 COC1=CC=C(Cl)C(CN2CCC(N(C)C[C@H1]3CCCO3)CC2)=C1Cl CC(C)CSCC(=O)NCC[C@H1]1CC(F)(F)CN1C(=O)[C@@H1]2CCC(F)(F)C2 COC1=CC=CC=C1CC(=O)N2CCCO[C@@H1](CN=C3N=C[NH1]S3)C2 CCN([C@H1](C)COC)[C@@H1](CC(C)C)C(=O)NCCOCC1CC1 C=CC1(C(=O)N2CCCC[C@H1](NC(=O)CCC3=CN=C[NH1]3)C2)CCC1 CC(C)[C@H1](O)[C@@H1](C)C(=O)N1CC[C@@H1](C(C)(C)NC(=O)[C@H1]2C[C@@H1](O)C2)C1 CCN(CCCNC(=O)C1(CCF)CCC1)C(=O)C2CCC3(CC2)OCCO3 C[C@@H1]1CCC[C@H1](CC(=O)N2C3CCC2(CNC(=O)C(C)(C)CCF)CC3)C1 CC=1C=C(CC(=O)N2CCC3(CC2)CN(C(=O)[C@@H1]4CC[C@H1]5C[C@@H1]4CO5)C3)N(C)N=1 CC(=O)C1=NC=CC=C1C(=O)N(C)CCOCCNC(=O)C2=CC=CC(C)=C2F CCCN1C[C@@H1](NC(=O)NCC2=CC=NC(C(F)(F)F)=C2)C(C)(C)C1 CCOC(=O)C=CC(=O)OCC[C@H1]1C[C@H1](NC(=O)OC(C)(C)C)C1 C[C@H1](O)[C@H1]1C[C@H1]1C(=O)N2CC[C@@H1](NC(=O)C=CS(C)(=O)=O)C23CCCC3 O=C(NC[C@H1]1[C@@H1]2CN(C(=O)C3=CN(CCO)N=N3)C[C@H1]12)C4=CC=C(O)C=N4 CCCCC[C@H1](C)CC(=O)NC12CC(CNC(=O)[C@H1]3C[C@H1](OC)C3)(C1)O[C@H1]2C CCCN(C)CCC(=O)N[C@@H1]1CN(C(=O)CCC(=O)OC)C[C@H1]1C2=CC=CC=C2 CC=1N=C(C(C)(C)C)SC=1C(=O)NCCN(C)C(=O)[C@H1]2COC(=O)N2 CC(C)[C@@H1](O)C(F)(F)C(=O)NC[C@@]1(C)CN(C(=O)C=2N=COC=2C3CC3)CCO1 CCOC(=O)CC1=CSC(NC(=O)CCC(=O)C2CC2)=N1 CC1(C)CN([C@H1](C(=O)NCSC2=CC=CC=C2)C3=NN=CN3C)CC[S@@]1=O O=C(C1=NN2C=CC=NC2=C1Cl)N3CCN(C(=O)[C@H1]4CCC4(F)F)[C@@H1](CO)C3 CC1=NN=CC=C1C(=O)N[C@@]2(CO)CCCN(C(=O)C3=CC=CC=C3Cl)C2 C#CCNC(=O)[C@]12C[C@@H1]1CN(C(=O)C=3C=CSC=3)C2 COCCN(C)C1=CC=CC=C1CN=C(N[C@H1](C)CCN(C)C)NC2CC2 CC1=CC=CC(C)=C1C(=O)NCCOCCCNC(=O)[C@@H1]2COCC[C@@H1]2C CCCN(C(=O)C=1C=C(COC)ON=1)C2CCN(C(=O)[C@@H1](O)C(C)C)CC2 CC1=CN=C([C@@H1](NC(=O)[C@H1](C)NS(=O)(=O)C2=CC=CC(Cl)=C2)C3CC3)S1 CC(C)NC(=O)[C@H1](C1=CN=C(C2=CC=CC=N2)N=C1)N(C)CC3=CC=C(Br)C=C3 C=C[C@@](C)(CC)C(=O)NCC1(OC)CN(C(=O)C2=CC=C(CCCC)C=C2)C1 CCCN1N=C(C)C=C1C(=O)N2CCCC[C@@H1](N(C)C(=O)CS(C)(=O)=O)C2 CN1C=C(Cl)C=C1C(=O)NCC#CCNC(=O)C2=CC(C3=CC=CN=C3)=NN2C CC1=CC=C(F)C(CN[C@@H1](CC2=CC=CC3=NON=C23)C=O)OC1F C[C@@H1]1C[C@H1]1CCNS(=O)(=O)C2=CC=C(NCC34CCN(CC3)CC4)C=C2Br O=C(NC1=CC=CC(SC(F)(F)F)=C1)N2CC[C@H1](C(F)(F)CO)C2 CC=CC=C(C)CC(=O)N1C[C@H1]2C[C@@H1](NC(=O)C(N)=O)CC[C@H1]2C1 C=CC[C@H1](OC)C(=O)N(C)[C@H1](C)C(=O)NCC1=CC=CC(C)=C1F COC(=O)C=1SC2=C(Br)C=CC=C2C=1NC(=O)C[C@H1]3CC4=CC=CC=C4O3 O=C(CN1CCS(=O)CC1)NC2=CC=C(OC3=NC4=CC=CC=C4O3)C=C2 N=C1N=CC(C(=O)N2CCCC[C@H1]2C3=CN(C[C@H1]4COCCO4)N=N3)=C[NH1]1 COC[C@H1](CNC(=O)[C@H1]1C[C@H1](SC)C1)NC(=O)C2=CC(C)=CC(OC)=C2 CC[C@H1](CC(=O)N1CC2(CN(C(=O)CC3(COC)CCCC3)CCO2)C1)C(F)F CCC(C)(C)OCC(=O)N[C@H1]1C[C@@H1](CCC(=O)NC[C@@]2(F)CCN(C)C2)C1 COC[C@H1](C(=O)N(C)C[C@@H1](O)CN(C)C(=O)C1=CC(O)=CC(O)=N1)C(F)(F)F CCC1(C)CC(C(=O)N[C@H1]2CN(C(=O)C=3SC=NC=3C(C)C)CC(C)(C)C2)C1 CCC(=O)NCC(=O)N[C@H1]1CCN(C(=O)CN2C=C(C(F)(F)F)C=C(Cl)C2=O)C1 O=C(CCSC(F)(F)F)N[C@H1]1CN(C(=O)C2=CC=CN=C2C3CC3)CC14CC4 CN1C=C(CCC(=O)N2C[C@H1]3CCN(C(=O)[C@@]4(C)CCCN4C)[C@H1]3C2)C=N1 CC[C@@](C)(O)CC1=CN([C@H1](C)C2=CC(Br)=CC(Br)=C2)N=N1 CC[C@H1](CNC(=O)[C@H1]1CC[C@@H1](C(N)=O)O1)NC(=O)[C@@H1]2C[C@@H1]3C=C[C@H1]2CC3 CCCC[C@H1](CC)CC(=O)N1C[C@@H1](NC(=O)C2=COC(C3CCC3)=N2)C[C@@H1]1C C#CCCCOCC(=O)NC[C@H1]1COC[C@@H1]1NC(=O)C2=CN=NS2 CC=1N=C[NH1]C=1[C@@H1](C(=O)NC[C@@H1]2CCCO2)N3CCC(CN4C=CN=N4)CC3 CN(C)[C@@H1]1CCCN(CCN2C(=O)N[C@H1](C3=CN=CC(Br)=C3)C2=O)C1 CC[C@@H1]1[C@@H1](NC(=O)[C@H1]2CCN(C3=CC=CC=C3)C2=O)CCN1C(=O)C=CCF CN1C=NC=C1C(=O)C(=O)N2CC(CNC(=O)C[C@H1]3CCOC3)C2 CCC=1C=NOC=1C(=O)N2CCN(C(=O)C=3N=NN4C=3CCCC4)C[C@@H1](O)C2 CC[C@]1(CNC(=O)C=2N=C(CNC(=O)COC3(C)CCCC3)OC=2C)CCCO1 C#CC[C@H1](O)C(=O)NC(C)(C)[C@@H1]1CCN(C(=O)C2=CC=CN=C2OCC)C1 CC1=NN=CC(C(=O)N(C)C[C@H1](C)C(=O)N2CCS[C@H1](C)CC2)=C1C C[C@H1](CC(=O)NC[C@H1]1CCC[C@@H1]1NC(=O)C2=CN(C3CCC3)N=N2)CC(C)(C)C C[C@H1](CC(=O)NC[C@@H1]1CCCN1C(=O)CC2=CN=C[NH1]2)CC3=CC=CC(F)=C3 COC[C@H1](C)CC(=O)N1CCN(C(=O)C2=CC=C(S(C)(=O)=O)O2)C[C@H1](C)C1 CC(C)[C@H1](C)CC(=O)N1CCC(N(C)C(=O)C2=C[NH1]N=C2Cl)CC1 C[C@H1](C(=O)NC[C@@H1]1CCC2(CCC2)[C@@H1]1NC(=O)C3=CC=NC(S)=C3)S(C)(=O)=O CC1=CN=C2N1CCN(C(=O)C(C)(C)[C@H1](C)NC(=O)[C@@H1]3CC[C@H1]4C[C@@H1]3CO4)C2 CC(C)C=1ON=CC=1C(=O)N2C[C@@H1]3CC[C@@]3(CC(=O)NC[C@H1](F)C4CCC4)C2 CCC[C@H1](C)NC(=O)[C@@H1]1CN(C(=O)OC(C)(C)C)[C@H1]2C[C@@H1]12 CCC(=O)N1CC(NC(=O)[C@@H1](C[C@H1]2CCOC2)N3C=CC=C3)C1 O=C(NCCN(C(=O)[C@H1]1CC[C@@H1](CC2=CC=CC=C2)C1)C3CC3)C4=CN=C(S)[NH1]4 CCSCCC(=O)NC1CC2(C1)CC(NC(=O)C3CCC(C(C)(C)O)CC3)C2 N#CC=1C=CSC=1C(=O)NC2(CCCC(=O)N3CC[C@@H1](C(F)(F)F)C3)CCC2 N#CC1=CC=C(NC(=O)[C@H1]2CN(CC3=NC=C(C(F)(F)F)[NH1]3)CCS2)C(F)=C1 O=C(CCC(=O)C1=CC=NC=C1)NC[C@]2(CNC(=O)[C@H1]3CC34CC4)CC2(F)F CCC1=NO[C@H1](CC(=O)N2CCCC[C@H1]2CNC(=O)C3CC(OC)(OC)C3)C1 CC1=CC(C(=O)N[C@H1](CNC(=O)C[C@H1]2CCCOCC2)C3CCC3)=CN1C CCC1(C#CC(=O)N2CCN(C(=O)CNC(=O)C3=COC(C#N)=C3)CC2)CC1 CC1=NOC(C(F)F)=C1C(=O)N2C[C@H1]3C[C@H1](NC(=O)[C@]4(C)CCC[C@H1]4O)C[C@H1]2C3 COC1=CC(C)=NC(C(=O)N(C)C[C@H1](O)CNC(=O)[C@H1]2CC[C@@H1]2C(C)(C)C)=C1 CC[C@@H1](CN(C)C(=O)CC1=CC(C)=NO1)NC(=O)COC2=CC(C)=CC=C2Cl C[C@]1(O)C[C@H1](C(=O)N2CC(CNC(=O)C3=CC=CC(NC(=O)C4CC4)=C3)C2)C1 CC1(C)CCC[C@H1](C(=O)N2C[C@H1]3[C@H1](CNC(=O)[C@H1]4C[C@@H1]4C5CCC5)C[C@H1]3C2)C1 CO[C@@H1](C)C(=O)N1CCN(C(=O)C2CCC(CCO)CC2)CC3(CC3)C1 COC1=CC=C(Cl)C=C1C(=O)N2CCCC23CN(C(=O)C4=C(O)C=CC=C4F)C3 OC1=CC=C(CN[C@H1]2CCO[C@@H1](C3=CC=CC=C3[N+1](=O)[O-1])C2)C=C1F CCCCCC(=O)N1CCN(CCNC(=O)C#C[C@H1]2CCOC2)CC1 CCS(=O)(=O)CC(=O)N1C[C@@H1]2C[C@]2(CNC(=O)C3=CSC(CCP(C)(C)=O)=N3)C1 C[C@H1](C(=O)N1CC(N(C)C(=O)[C@@H1]2CC[C@H1](N=[N+1]=[N-1])C2)C1)C3=CC=C(F)C=C3 CC=C(C=CC(=O)NC[C@H1]1CCC2(CN(C(=O)[C@@H1](C)S(N)(=O)=O)C2)O1)CC C[C@@H1]1C[C@@H1](NC(=O)CN(C)C2CCC2)CN(C(=O)CCOCC3CC3)C1 C[C@H1](CN1C=NN=C1)NC(=O)[C@@H1]2C[C@H1](F)CCN2C(=O)CC3=CN=CN=C3O COCCC[C@@H1](C)C(=O)N1CCN(C(=O)C2=CN=C3N=CC=CN23)C[C@@H1](CO)C1 CS[C@@H1](C)C(=O)N1CC2(CCC2)C[C@@H1]1CNC(=O)CCCCCNC(N)=O O=C([C@@H1]1CC2(CCC2)CO1)N3CC4(CO)CC3(CNC(=O)[C@@]5(F)CCOC5)C4 O=C(NC1(CF)CCCC1)[C@@H1]2CC[C@H1](NC(=O)[C@@H1](O)C3CCOCC3)C2 O=C(N[C@@H1]1CCC[C@@H1]2CN(C(=O)CN3C=NN=C3O)C[C@@H1]21)C4=CC(CO)=CC=N4 O=C(CC1=CC=NC=C1Cl)NCC[C@H1]2CN(C(=O)C[C@@H1]3CC=CCC3)CCO2 C=CCC1(NC(=O)C[C@@H1]2CCCOCC2)CN(C(=O)C3=CC(C)=C(Cl)C(C)=C3)C1 CCOC(=O)C(F)=C(N)C(=O)C1=CC2=C(Br)C=C(OC)C=C2[NH1]1 CC1=CC=C(F)C(C(=O)N2CC[C@@](CO)(C(=O)NCC=3OC=NC=3C)C2)=N1 C=CCOC[C@H1](C(=O)NC1(CN(C)C(=O)C=2ON=CC=2CC)CC1)C(C)(C)C N#C[C@@H1]1CCCN(C2=NC(=NCCC=3C=COC=3)[NH1]C=4C=C[NH1]C2=4)C1 C[C@@H1]1CCOCN1C(=O)[C@@H1]2CC[C@H1](NC(=O)C3=CN=NC(O)=C3)C2 COCCOC1CCN([C@H1](C(=O)NC[C@H1]2CCCO2)C=3SC(C)=NC=3C)CC1 CC(=O)N(C)CCC(=O)N1C[C@H1](C#N)[C@H1](NC(=O)C2=CN3C=C(Cl)C=CC3=N2)C1 CON=CC(=O)N[C@@H1]1CCCN(C(=O)CCCC=2SC=CC=2C)CC1 CN(CC1(NC(=O)CN2C=CC=C(N)C2=O)CC1)C(=O)C3=CC=NN=C3O CC(C)(C)C1=NC(=N)[NH1]C(=N[C@@H1]2C[C@H1]3CC[C@H1]2CC34OCCO4)[NH1]1 C#CC1=CN=C(C(=O)N2CCC[C@@H1](NC(=O)C=3C=CC4=NC=CN4N=3)C2)C(C)=C1 CN1C=NN=C1CCC(=O)N2C[C@H1]3CC[C@H1]2CN(C(=O)C[C@@H1]4CCCC4(F)F)C3 COC(=O)[C@@]1(N)CCCN(C(=O)C2=CC(Br)=C(Cl)C=C2C)C1 CCCCS(=O)(=O)NCC(=O)N[C@H1](C)[C@H1]1CCCN1C(=O)[C@@H1](C)NC(C)=O CCOC(=O)CC1=CC=CC(NC(=O)[C@@H1]2CN(C(=O)C3=NC=C(Cl)S3)CCN2)=C1 CC1(C)C[C@H1](CC(=O)NC[C@@]2(O)CCOC2)CN1C(=O)CC=3C=CSC=3 C=CCCC(=O)NCC=1N=COC=1CCNC(=O)C[C@@H1]2CCCNC(=O)C2 CC1=C(C(=O)NCC(C)(C)CNC(=O)[C@H1]2CCC(C)(C)O2)OC3=CC=C(Cl)C=C13 CCN(CC1CCN(C(=O)[C@H1]2CC=C(C)CC2)CC1)C(=O)C3=NC=NC(C)=C3C CC[C@H1]1CN(C(=O)CN(C)C(C)C)CC[C@H1]1NC2=NC=CC(N3C=CN=C3)=N2 O=C(NCCN1C=C(Br)C=N1)C2=CC=CC(C3=CC=C([N+1](=O)[O-1])C=C3)=C2 CC[C@H1](C)CN(C)CCN(C(=O)[C@H1]1CCC2=C(Cl)C=CC=C21)C(C)C N#CCC(=O)N1CC[C@H1]2[C@H1]1CCCN2C(=O)C=3C=CC4=NC=NN4C=3 O=C([C@H1]1C=CCC1)N2C[C@H1](C(=O)N3CC[C@H1](CCO)C3)C4(CC4)C2 CC1=NOC(C)=C1CC(=O)N[C@@](C)(CNC(=O)C2=CC=3SC=CC=3N2C)C4CC4 CCSC1(C(=O)N2CCOC[C@@H1](CNC(=O)C=CC3=CC=CS3)C2)CC1 O=C(CCSC1=CC(F)=CC=C1F)NCC[C@@H1]2CCCN2C(=O)CC3(O)CCC3 CCOC1(CNC(=O)[C@@H1](CN(C)C)NC(=O)CC2(N(C)C)CC2)CCC1 C=C1CCN(C(=O)C2=CC=C(C)C=C2F)[C@@H1](C(=O)N3CC(O)(C=4C=C[NH1]N=4)C3)C1 CC(C)CN1CCC[C@H1](C(=O)N2CC[C@H1]3CCC[C@]32CNC(=O)C4=CSC=N4)C1 CS[C@@H1]1COC[C@H1]1NC(=O)[C@@H1]2N(C(=O)[C@H1]3CC3(C)C)CCC2(C)C CN1CCCN(CC(=O)N2CCC[C@@H1]2C3=CC=C(C(C)C)O3)CC1 O=C(N[C@@H1]1CC[C@H1](CC(=O)N2CC[C@H1](CO)[C@H1](O)C2)C1)[C@@H1]3CCC4(CCC4)C3 O=C(NC[C@@H1](F)CO)C1=NC=C2C=CC=CN12 C[C@H1](NC(=O)[C@@H1]1C[C@@H1]2CCC[C@@H1]2N1C(=O)C34CCC(C3)C4)C5CCCCC5 CC[C@](C)(CNC(=O)C1C[C@H1]2COC[C@@H1]2C1)C(=O)N(C)CC3=CN(C)C=N3 C=CCC[C@@H1](NC(=O)CC/C=C/C(C)C)C(=O)N[C@H1]1CCOC1(C)C CCOC(C)(C)C(=O)N(C)C[C@H1](C)CNC(=O)C1=CC(OC)=C(C2CC2)N=N1 CC1=CN(C)C=C1C(=O)NC[C@@H1]2[C@H1]3C[C@H1]3CN2C(=O)C4=CCSC4 COC1=CC=C(C2=CN=C(CN(C)C(=O)[C@]3(C)COC(=O)N3)N=C2)C=C1 CO[C@@H1](C)CC(=O)N1CC([C@@H1]2CCCN(C(=O)COCCCF)C2)C1 COC1=CC(=O)N(C)C=C1C(=O)N2C[C@@H1](C)C(NC(=O)C=C(C)C(C)C)[C@H1](C)C2 C=CCCOCCCCC(=O)N[C@@H1]1CC[C@H1]1NC(=O)C2(COC)CC(=O)C2 CC1=NC=C(C=CC(=O)NC[C@H1]2CN(C(=O)CC3=CC=CC(Cl)=C3)C[C@H1]2O)S1 CCN(C(=O)[C@@H1]1C[C@H1]1COC)[C@@H1]2CCCN(C(=O)C3=C(C)C(C)=NN(C)C3=O)C2 CCC[C@H1](O)C(=O)NC[C@@]1(C)CCCN1C(=O)[C@@H1](C)CC=2C=NN(C)C=2 COCC1=CC(C(=O)N[C@H1]2CN(C(=O)CN3C[C@H1]4CC[C@H1]3C4)C[C@@H1]2C(F)F)=N[NH1]1 CS[C@@H1](C(=O)NCC[C@H1](C)N(C)C(=O)C1=CC(F)=C(O)C(Cl)=C1)C(C)C C[C@@H1]1CCN(C(=O)C2CC3(CC(C#N)C3)C2)[C@@H1]1CNC(=O)C4=NNC(=O)CC4 COCCCNC(=O)[C@@H1]1CN(C(=O)[C@H1]2CCC[C@@H1]2O)CCO1 COC(=O)[C@H1](C)[C@H1]1CCCN1C(=O)C2=COC(=N)[NH1]2 CC#CCCCC(=O)N1C[C@@H1](NC(=O)C=2C=NSC=2C)CC[C@H1]1C O=C(C=CC1=CC=CC=C1F)NCCN2C=NC(C(=O)NC[C@H1]3C[C@H1]3CO)=C2 C#C[C@@H1](C)NC(=O)C1=CN(C2CCN(CC3=CC=C(C(=O)OC)[NH1]3)CC2)N=N1 CCN(C(=O)C1=CC=C([C@@H1](O)CF)C=C1C)[C@@H1]2CCN(C(=O)C3=NOC=C3C)C2 C=C(C)C[C@@H1](NC(=O)[C@@H1](C)OCC1CC1)C(=O)NC2CC(C)(CC)C2 CC1=CC(CC(=O)N2CC[C@]3(C[C@H1]3NC(=O)[C@H1]4C[C@H1](N5C=NN=C5)C4)C2)=NN1C COC(=O)C1=CC=C(F)C(CN2CCC[C@H1](NC(=O)[C@@H1]3CC=C(C)CC3)C2)=C1 C[C@H1](CF)CC(=O)N1CC[C@@]2(CCN(C(=O)C3=CC(N)=CN=C3Cl)C2)C1 CC(C)CCC=CC(=O)N1C[C@H1](C(=O)N(C)C=2C=CSC=2)CC1(C)C C=CC[C@H1](CNC(=O)[C@@H1]1CCC[C@H1]1C)NC(=O)C2=CC=CC3=CC=CN=C23 C=C[C@H1]1OCC[C@@H1]1C(=O)N2CC3(CC3)C[C@H1]2CC(=O)N4[C@H1]5CC[C@H1]4CC(CC)C5 O=C(N[C@H1](CO)CNC(=O)C1=CC(=O)C2=CC=NC=C2O1)C3=CC=C(F)C(Cl)=C3 CC1=CC=CC(OCC(=O)N[C@@H1]2C[C@H1]2NC(=O)CSC3=NC4=CC=CC=C4S3)=C1 C[C@@H1](OC1=CC=CC=C1)C(=O)N2CC(=C(F)CNC(=O)C3=CC=NN3CCF)C2 C[C@H1](C(=O)NCC1(O)CN(C(=O)C=2C=NN(CCF)C=2)C1)N(C)C O=C(N[C@H1]1[C@@H1]2CN(CC3=CC=CC4=C3OCO4)C[C@@H1]21)[C@H1]5CCN6C=CN=C6C5 CC(C)C[C@@](C)(O)CNC(=O)CCCCCNC(=O)[C@@H1]1CCOC1(C)C COCC=1C=C[NH1]C=1C(=O)N(C)CCN(C)C(=O)C2=N[NH1]C(C)=C2Br CC1=CC=C2C(Cl)=C(C(=O)N3CCN(C(=O)C=4C=NN(C)C=4)CC3)SC2=C1 O=C(C1=CN=CN=C1)N2CCC[C@]3(CCN(C(=O)C4=C(F)C=NC=C4Br)C3)C2 CC(C)[C@H1](F)C(=O)N[C@@H1]1CC[C@H1](CCNC(=O)[C@H1](C)CCC(C)(C)C)C1 O=C(CCF)N1CCN(C(=O)CCOCCCN2C=C(CN3C=CC=N3)N=N2)CC1 O=C(C=CC1CCCCC1)NCC[C@H1]2C[C@H1](NC(=O)CC3CCC=CCC3)C2 CC[C@@H1](CC(=O)NCC1=NC(C(=O)N[C@@H1](CO)CC2=CC=CO2)=CO1)CN(C)C CC1=NC=CN=C1CCNCC2=CC=CC=C2O CC1=C(CC(=O)N2C[C@H1](CNC(=O)CCCNC(N)=O)C(C)(C)C2)N=CN1C CCCCC/C=C/C(=O)N1CC2(C[C@@H1]2C(=O)NCC3OCCO3)C1 C#CCN(CCC(=O)NC[C@@H1]1C=CCC1)C(=O)[C@@H1](O)CCCC C#CCC(C)(C)CNC(=O)[C@@H1]1CO[C@H1](CNC(=O)C=2C=C(OC)N(C)N=2)C1 C[C@@]1(CNC(=O)C=CC2CC2)CCN(C(=O)C3=CC=CC(OC(F)(F)F)=N3)C1 O=C([C@@H1]1COCCN(C(=O)C2(CO)CCOCC2)C1)N3CC[C@@H1]4CCC[C@H1]4CC3 C#CCN1C=CC=C1C(=O)NCC2=CC=C(C(=O)N3CC[C@H1]3C)O2 COC1(OC)CC(C)(C(=O)N[C@@H1](CNC(=O)CC[C@@H1]2CC2(C)C)C3CCC3)C1 CN1C[C@@H1](C(=O)N[C@](C)(CNC(=O)C23CC(C)(C2)C3)C4CC4)CC1=O COC1=CC=C2C(=C1)[C@H1](C(=O)N[C@@H1]3CN(C(=O)C=C(C)Cl)CC[C@H1]3F)CCC2 CC1=CN=C(CCC(=O)NC[C@](C)(O)CNC(=O)[C@@]2(O)CCOC2)[NH1]1 CCOCCC1(CN[C@H1](C2=CC(C)=CC=C2Br)C3=NN=NN3C(C)(C)C)CCC1 O=C([C@@H1]1CC[C@@H1]2CCCC[C@@H1]2C1)N3CCCN(C(=O)CSCC4=CC=CS4)CC3 C[C@H1](C(=O)N[C@H1]1CC[C@H1]2CCN(C(=O)C3=CN=CC=C3Cl)[C@H1]1C2)C=4C=CSC=4 CC(=O)C1=CC=C(C(=O)N2CCC=C(CNC(=O)C3CCC3)C2)C(F)=C1 COC(=O)[C@@]1(C(=O)N2CCC[C@H1](C3CCN(C4=NC(C)=NS4)CC3)C2)C=CCC1 C=C[C@H1]1C[C@@]1(CO)CNC(=O)[C@@H1](CCC)NC(=O)C=2C=C3C=CC=CN3N=2 C#CCCCCCCC(=O)NCCC[C@@H1](O)C(=O)N(C)CC(C)(F)F CC1=CC(C)=C(C(=O)NC[C@H1](CC2CCCC2)C(=O)N3CC[C@H1](CF)C3)S1 CNS(=O)(=O)CC(=O)N1CC[C@@H1](C(=O)N(C)C2(C)CCCC2)[C@H1]1C(C)C CCCC(C)(C)C(=O)N[C@@H1]1CCN(C(=O)CCCC(F)(F)F)[C@H1](C2CC2)C1 CC1=CC(C)=CC(CCC(=O)N[C@]2(C)C[C@H1](NC(=O)[C@H1]3CCCC[C@H1]3C)C2)=C1 CC1(C)C[C@@H1](NC(=O)C2(N3C=CC=N3)CC2)CN(C(=O)C[C@@H1]4OCCC4(C)C)C1 C[C@H1](C(=O)N[C@H1](C)CN(C)C(=O)[C@H1]1CCCC(C)(C)CC1)C2=CC=C(F)C(F)=C2 C[C@H1](N=C1C=CC2=CC=C([N+1](=O)[O-1])C=C2[NH1]1)C3=CC=CC=C3O O=C(C[C@@H1]1CN2CCN1CC2)N[C@H1]3C[C@@H1](O)[C@H1](NC(=O)C4=CN=NC(O)=C4)C3 CC1=NC=C(C(=O)N[C@H1](C(=O)N[C@@H1]2CCN(C)C[C@@H1]2C#N)[C@H1]3CC=CCC3)C=N1 O=C(NC[C@@]12CC[C@@H1](C1)N(C(=O)C3=CNC4=NCCCN34)C2)C5=CSC=N5 O=C(CC1CSCCS1)N[C@@H1]2CCC[C@H1](CNC(=O)[C@@H1](O)C3CC3)C2 CN(CC=1SC=CC=1Cl)CC2=CC=CC(C3=CC=NC(CN)=N3)=C2 C=C[C@H1]1CN(C(=O)[C@H1](C)SC(C)C)C[C@H1]1NC(=O)CCNS(=O)(=O)C2=CC=CS2 C[C@H1]1CN(C(=O)C2=COCCO2)CC[C@H1]1CNC(=O)C=3C=C4N(N=3)CCCN4 CC1=NC(Cl)=C(C)C(=NC[C@H1]2C[C@@H1](C)N(C(=O)C3=CN=C(CO)N=C3C)C2)[NH1]1 CC1=CC=C(OC(F)(F)F)C(C(=O)N2C[C@H1]3C[C@@]3(NC(=O)[C@H1]4C[C@H1]4C)C2)=C1 O=C(CCCF)NC[C@@H1](CC1CCCC1)C(=O)N2CCCC=3OC=CC=3C2 CC[C@]1(C)C=C(C(=O)N2CCC(CN(C)C(=O)CN3CCCOC3=O)CC2)C1 COC(=O)NCC(=O)N1CC[C@](C)(CNC(=O)C[C@@H1]2CCCC[C@H1]2C)C1 CC=1OC(C2CC2)=NC=1C(=O)N[C@@H1]3C[C@H1](NC(=O)[C@H1]4CCC5=C[NH1]N=C54)C[C@H1]3O CC1=NON=C1CC(=O)NC[C@H1]2CC[C@](F)(CNC(=O)CN3N=CN(C)C3=O)C2 CN1N=CC=C1C#CC(=O)NCC(C)(C)C2NCC2 CC(C)=CCONC(=O)[C@H1]1C[C@@H1](NC(=O)C2(C)CC(C)(C)C2)CCO1 O=C(N[C@H1]1C[C@H1]1CNC(=O)C2=CC=CC=C2OCC3CC3)C4C=CC=CC=C4 COC(C)(C)C[C@@H1](C)NCC(=O)NC1=CC(C)=NS1 COCN1N=CC=C1C(=O)N(CCNC(=O)CC2CCOCC2)C3CC3 CC(C1)O[C@H1]2CCN(C(=O)C3=NO[C@@H1](CNC(=O)C4(C)CCOCC4)C3)[C@H1]2C1 CC(C)CCCC(=O)N1CC[C@H1]2CCC[C@@H1](C1)N2C(=O)[C@H1](F)C(C)(C)O CC1=NC(CN(C)C(=O)C2=C(CNC(=O)CC=3C=CSN=3)N=NN2C)=NO1 C#CCOCCC(=O)N1CC[C@@H1](C)C[C@H1]1CNC(=O)CSC2CC2 CC=1C=C(C(=O)N(C)[C@H1](CNC(=O)C=2SC(C3=CC=CS3)=NC=2C)C4CC4)ON=1 CCCOC1=CC=C(Cl)C=C1CC(=O)N2CC(C[C@@H1](C)NC(=O)C=3C=NSN=3)C2 CS[C@H1](C)CC(=O)N1CCN(C(=O)C2=CC=C(C)N=C2C(C)C)C[C@H1]1C(C)(C)C CC(C)[C@@H1](OC(=O)CC1=CC=C(I)C=C1F)C(=O)N(C)C2=CC=CC=C2 CC12CCC(C(=O)N[C@H1]3C[C@@H1](NC(=O)[C@@](C)(O)CC(F)(F)F)C3)(CC1)C(C)(C)O2 CC1=CC=C(Cl)C=C1N[C@](C)(C2=NN=NN2CC(F)F)[C@H1]3CCN(C)C3 CN1N=C(C(=O)N2[C@@H1][C@H1]3CCN(C(=O)C4=CC(N)=C(O)C(F)=C4)[C@H1]32)C=C1Cl CC1=CC(CCC(=O)N[C@H1]C2C[C@H1](NC(=O)[C@H1](CC[S@@](C)=O)N(C)C)CC2)=N[NH1]1 CCC=1OC=C(C)C=1C(=O)N(C)CCC(=O)NOCC2(C)CCC2 CCCC[C@H1]1C(=O)NCCN1[C@H1](C(=O)NCC)C2=NC=C(OCC)C=N2 CCN1C=C(C(=O)N2CCC(C)(CNC(=O)[C@@H1]3CCOC[C@@H1]3C)CC2)C(C)=N1 CC1=CC=C(OCCC(=O)NC[C@@H1]2CC[C@H1]2NC(=O)C[C@@H1](C)N3C=CC=N3)C=C1 CN(CC(C)(C)NC(=O)CN1CSCCSC1)C(=O)C=2C=NC3=C[NH1]N=C3C=2 COC1=CC=C(CC(=O)N(C)C[C@H1](O)CNC(=O)C2=CC=NC(C(F)F)=C2)N=C1 CN1C=NC=C1[C@@H1](O)C(=O)N[C@H1]2[C@@H1]3CC[C@@H1](C3)[C@H1]2C(=O)NC4(CC(N)=O)CC4 CC=1C=C[NH1]C=1C(=O)NCC23CC(NC(=O)[C@@H1](C)CNC4=CC=CC=C4C)(C2)C3 CCN1C=C(Cl)C(C(=O)N2C[C@H1](NC(=O)C=3N=C(Cl)SC=3C)C[C@@]24CCOC4)=N1 C=C[C@](C)(O)C(=O)NCC1CN(C(=O)C2CN(C3=NC=C(F)C=N3)C2)C1 C[C@H1]1CN(C(=O)C[C@H1]2CN3CCN2CC3)CCN1C(=O)[C@@H1]4CC5=CC=CC=C5O4 C#CC1(C(=O)N[C@H1]2C[C@H1](NC(=O)C3=CC(F)=C(F)C=C3Cl)C24CCC4)CCCC1 C#CC[C@H1](NC(=O)[C@H1](F)CC1=CC=CC=C1)C2=CC=CC=C2 O=C(NC[C@H1]1CN(C(=O)[C@@H1](F)CC2CC2)CCO1)C3=N[NH1]C4=NC=CC(Cl)=C34 O=C(N[C@@H1]1CCN(C(=O)C2=CN3C(=N2)CCCC3)C[C@@H1]1CO)C4=CSC=C4Cl O=C(NC[C@@H1]1CCCN1C(=O)[C@@H1]2COC3=CC=C(Br)C=C32)C4CC(F)(F)C4 CC=1SC=C(C(=O)N2CC(CCO)(NC(=O)CN(C)C(=O)C=3C=CSC=3)C2)C=1C CSCC[C@H1](O)C(=O)N1C[C@@H1](CNC(=O)C2(CCF)CCOCC2)C(F)(F)C1 C[C@H1]1CN(C(=O)[C@@H1]2CCS[C@H1](C)C2)CC[C@H1]1CNC(=O)C3=CN(C)C(=O)N=C3O C[S@@](=O)C1(CNC(=O)NNC2=CN=CN=C2)CCC1 CN1C=CC(CC(=O)NC[C@H1]2CN(C(=O)CSC3=NN=CN3C4CC4)C[C@H1]2O)=N1 CCN1N=NC=C1C(=O)N(C)C2CCN(C(=O)CCC3=NN=CS3)CC2 O=C1C[C@@H1](C(=O)N2CC3=CC=C(CNC(=O)C4=CC=C(Br)O4)C=C3C2)CCN1 CO[C@H1](C)CC=1N=C(CC2CCC(C)CC2)N(C3=CC(F)=CC(CO)=C3)N=1 O=C(N[C@@H1]1CCN(C(=O)C2(O)CC2)CCC13CCC3)C4=CN5C(=N4)CCC5 CC1=CN=CC(C(=O)NCCCN(C)C(=O)[C@@H1](C2=CC=C(Cl)C=C2)C(C)C)=C1C C=C[C@@H1](C)N(C)S(=O)(=O)C=1[NH1]C(=N[C@H1]2CCN(C3CC3)C2)C=CC=1Br C[C@@H1]1C[C@H1]2CN(C(=O)C(F)(F)C3=NC=CC=N3)C[C@H1]2N1C(=O)CCC4CCCC4 CO[C@H1]1C[C@@H1](CNC(=O)C2=CC=CC3=C2OC[C@H1]3C)N(C(=O)C=4C=NSC=4)C1 CC#CCCCC(=O)N1CC2(C1)SCC[C@H1]2NC(=O)CSC3=NN=CN3C4CC4 CCC1=CC(O)=NC(NCC2(N)C=CCC2)=N1 CCCOC1=CC=C(C(=O)N2CC(CO)(NC(=O)C3CCN(C)CC3)C2C)C=C1 C=CCCCCCCCCC(=O)N1CCC[C@](F)(CNC(=O)[C@H1]2CC2(Cl)Cl)C1 C[C@@H1](C[C@@H1]1CCCO1)C(=O)N2CCC(CN(C)C(=O)C=3C=CSC=3Cl)CC2 C#C[C@H1](CC1CC1)NC(=O)[C@@H1]2COC3(C2)CN(C(=O)C4(N5N=CC=N5)CC4)C3 CO[C@@H1]1C[C@@H1](CN)N(C(=O)NC2=CC=CC(N3CCCC3)=C2)C1 CCC(C)(CC)C(=O)N1CCN(C(=O)[C@H1]2SCCC=3SC=CC=32)C[C@](C)(F)C1 CC(C)[C@H1](NC(=O)CC=1SC=CC=1Cl)[C@@H1](C)NC(=O)CCC2=NC=CN2C CC=NN=C(CC(=O)N[C@@H1](CNC(=O)[C@H1](C)C1=CC=C(C(F)F)C=C1)C(C)(C)C)O CN(C(=O)C1=CN=C2C=CC(C#N)=CN12)C3CCC(NS(=O)(=O)C4CC4)CC3 CCCN(C(=O)[C@@]1(C)C=CCC1)[C@@H1]2CCN(C(=O)CCC3=CC=CC=C3F)C2 CCN(CC(=O)N1CC[C@H1](NC(=O)COC(F)(F)C(F)(F)F)[C@@H1](O)C1)C2CC2 CC(C)OC(=O)CNC(=O)CC[C@@H1](C)NC(=O)C1(C(C)(F)F)CC1 CC1=NC(C(=O)NC[C@@H1]2CCN2C(=O)CC3=CC=CN=C3Cl)=N[NH1]1 O=C(O)[C@]1(F)CCCN(CC2=CC=CC(C3=CC=C(F)C=C3O)=N2)C1 CCC[C@H1](F)C(=O)NCC1=CC=C(C(=O)N[C@@H1](CCC)C2CCCC2)C=N1 C=CCCOCC(=O)N[C@@H1](CNC(=O)[C@@H1]1CCCN(S(N)(=O)=O)C1)C(C)C CCOC1=CC=C(CC(=O)NC2(C)CN(C3=NC=CC(CO)=N3)C2)C=C1 CNS(=O)(=O)N1CCC(NC(=O)C=2C(O)=CC(=O)N3C=2COCC3)CC1 CN(CC(CNC(=O)C(C)(C)O1)CC1)C(=O)C2=C[C@@H1]3CCCCCC[C@@H1]23 NC[C@H1]1CN(C(=O)C(=O)NCCN2N=C(C3=CC=CS3)C=CC2=O)C[C@H1]1C(F)F CC(C)[C@@H1]1CN(C(=O)C=2N=CN3C=C(C4=CC=CC=C4Cl)SC=23)C5=NC=CN5C1 C=C(C)CCCC(=O)N[C@@H1]1CCN(C(=O)C2=CC=C(OC)C(O)=C2)C[C@H1]1CC CN1N=CC=C1CNC(=O)[C@@H1]2CC23CCN(C(=O)C/C=C/C(C)(C)C)CC3 CO[C@](C)(CO)C(=O)NCC1=N[NH1]C2=C1CN(C(=O)[C@@H1](C)OCC(F)(F)F)CC2 CC1=CC=NC2=C(C(=O)N3CCC[C@@](C)(NC(=O)C(N)=O)C3)C=CC=C12 CC[C@@H1](CNC(=O)C1CCN(C(=O)[C@@H1](CC2=CC=CC=C2)OC)CC1)N(C)C CCNC(=O)CC(=O)N1CCC[C@H1]1CC(=O)N2CC[C@H1]2C(=O)N(C)C CC[S@@](=O)CC(=O)NCC[C@H1](C)NC(=O)CC1=CN=CC=C1C COC1=CC=C(C[C@H1](C)N=C2C=C(NCCN3C[C@H1]4C[C@@H1]4C3)N=C(COCC)[NH1]2)S1 O=C(C=1N=N[NH1]C=1Cl)N2CCC[C@H1]3[C@@H1]2CCCN3C(=O)C4=CC=C5N=N[NH1]C5=N4 C=C(Cl)C(C)(C)C(=O)N1C[C@@H1](CNC(=O)CN(C)CCC)C(C)(C)C1 CCC=C(F)C(=O)NCC1(C(N)=O)CN(C(=O)[C@H1]2[C@H1]3CC[C@H1]4[C@@H1](C3)C[C@H1]42)C1 CCOC1=CC=C(C)N=C1C(=O)N2CCCC[C@@H1](NC(=O)[C@H1](C)NC(N)=O)C2 CC(C)[C@@H1](O)CC(=O)N1CCCC[C@@H1]1CCNC(=O)[C@H1]2C[C@H1]3C=CC[C@@H1](C3)C2 CCC[C@H1](NC(=O)[C@H1]1CC2(CC2)CO1)C(=O)N(C)CC3=NC=C(C)O3 CC(C)(C)NCC(=O)N1CCC[C@](F)(CNS(=O)(=O)CCCN2CCOCC2)C1 O=C(NC1=NC2=CN=CC=C2S1)C3=CC=C([N+1](=O)[O-1])C(C(F)(F)F)=C3 CCCCO[C@@H1]1CCCN(C(=O)C=CC2=CC=C3C(=C2)OCCO3)C1 COC1(C(=O)N2CC(O)(CNC(=O)[C@@H1](O)C3=CC=CC=N3)C2)CCSCC1 CSCC=1C=C(C(=O)N2CC(NC(=O)[C@H1]3C[C@@H1](C)NC4=CC=CC=C43)C2)SC=1C CC1=CC(C(=O)NC[C@H1](C)N2C=C(C3(S(N)(=O)=O)CC3)N=N2)=C(C)C=C1Cl CCS[C@H1](C(=O)NCCN(C)C(=O)C1=CC=NC(OC(F)F)=C1)C(C)C CC1(C)[C@@H1](CNC(=O)C2=CC3=CN=CN3C(O)=N2)CCN1C(=O)CN4CCCC4 CC=1N=N[NH1]C=1C(=O)NC[C@@]2(C(=O)N3CCC[C@@H1](N=[N+1]=[N-1])CC3)CCCO2 CN(CC1(C)CCCC1)C2=NC(=NCC[C@@H1]3CCCC3(F)F)[NH1]C4=C2CCCC4 C[C@H1](C1=CN(CCN2C=CC=N2)N=N1)N(C)C(=O)CN3C=NC4=CC=CC=C43 CC1=CC=C(S(=O)(=O)N(C)C)C=C1C(=O)N=CC(=C[NH1]C=N)N2C=CC=CC2 CC1=NN2N=CC=CC2=C1C(=O)NC[C@H1]3C[C@@H1]3NC(=O)C4=N[NH1]C5=C4CCC5 CC=1N=CSC=1CCNC(=O)[C@@H1]2CCN(CC3=CC=C(Cl)C=C3)C[C@H1]2O C=CCCCCC(=O)N1CCC(O)(CNC(=O)C2=CC(Cl)=NC=C2OC)CC1 CCC1(C)CCC(NC(=NCC[C@H1]2OCC[C@H1]2C)NCC)CC1 C[C@H1](O)/C=C/C(=O)N1CC[C@@]2(NC(=O)CC(C)(C)C)CCC[C@@H1]12 CC1=NSC=C1C(=O)N[C@H1]2CN(C(=O)CC3CS(=O)(=O)C3)CC(F)(F)C2 CC1=NC=C(F)C(N2CC(=C(F)CNC(=O)[C@@]3(C)C[C@H1]4CC[C@H1]3C4)C2)=N1 CO[C@H1](C(=O)N1C[C@@H1]2C[C@H1]1[C@@H1]2CNC(=O)[C@H1]3CCCC34CC4)C5=CC=C(F)C=C5 CN1CC=CC[C@@H1]1CC(=O)N(C)[C@@H1]2CN(C(=O)C(C)(C)C3CC3)C[C@H1]2O COC1=CC=CC=C1[C@@H1](C)CC(=O)NC[C@H1](C)CN(C)C(=O)C2=C(Cl)CC2 CC[C@H1](CC(=O)N1CC(COC)(NC(=O)[C@@H1](C)CC2=CC=C(F)C=C2)C1)SC O=C(OCCC1=CC=C(F)C=C1I)C2=CC=CC=C2CN3C=NC=N3 CN(CC1CCN(C(=O)C2=CC=CC(N)=C2O)CC1)C(=O)CC=3C=C[NH1]N=3 CCC1=NO[C@H1](CC(=O)N[C@]2(C)C[C@@H1](NC(=O)[C@H1]3CCCC4=CC=NN43)C2)C1 C[C@@H1](C(=O)NCCOCCOCCCNC(=O)CC1CSC1)[C@H1]2CCC(=O)N2C COC1=CC=NC(C(=O)NC[C@@H1]2[C@H1]3CC[C@H1](C3)N2C(=O)C(F)(F)[C@@H1](C)O)=C1 CC(C)C1=CN=CC(C(=O)N(C)CCN(C)C(=O)C=2C=NN(CC(F)F)N=2)=C1 CCCN(CCNC(=O)[C@H1](C)OCC1=CC=CC=C1)C(=O)C2COC2 CCC1(C(=O)N(C)CC2(NC(=O)C3=CN=C(N)C([N+1](=O)[O-1])=C3)CC2)COC1 C[C@H1]1C[C@@]1(NC(=O)C[C@H1](O)C2CCCC2)C(=O)N(C)CC3=CC=NC=C3 CC(=O)NC1=CC(F)=C(F)C=C1NC(=O)C=2C(C)=NN(C)C=2N3C=C(C)C=N3 COC1=CC=C2[NH1]N=C(C(=O)N(C)CCOC3=CC=CC=C3Cl)C2=N1 C=CCCCCCC(=O)N[C@]1(C)C[C@@H1](NC(=O)C2=NC(C)=C(C)N=C2C)C1 CC[C@@H1](CNC(=O)[C@H1](CC)CCOC)NC(=O)CCC1=CN=CC(O)=C1 O=C(C1=CC(C2CC2)=NC3=CC=CC=C13)N4C[C@H1]5CN(CC6=CC=CC=C6)C[C@@H1]5C4 CN(C)CC/C(Cl)=C/C(=O)N(C)CCOCCN(C)C(=O)CN1CCC(O)CC1 CC(C)C1CC(C(=O)N2C[C@@H1](O)[C@H1](N(C)C(=O)C=3C=NN(C(C)C)C=3)C2)C(C)C1 COC1=C(Cl)C=CC=C1C(=O)N[C@@H1]2CN(C(=O)C3=C(C)N=C4SC=CN34)C[C@@H1]2F CC1=CC=C(SCC(=O)N2CC([C@@H1]3CCN(C(=O)C4=CC=NC=C4)C3)C2)C(C)=C1 O=C(CC=1C=CON=1)NCCCOC2CCN(C(=O)CC(F)(F)C(F)(F)F)CC2 CC[C@](C)(OC)C(=O)NC[C@H1](CC(F)(F)F)NC(=O)CN1C=CC=CC1=O CC1=CSC(Cl)=C1C(=O)N2CC[C@H1](NC(=O)C3=CC=CC(N)=N3)C(F)(F)C2 CC1=NC(CN2CC(N3CCN(C(=O)[C@H1](O)C4CC4)CC3)C2)=CS1 C[C@H1](C(=O)N1CC2(CCOCC2)[C@@H1]1C3=CC=CC=C3F)N4C=C(CO)N=N4 O=CNCC(=O)N1C[C@H1]2CC[C@H1]1[C@@H1]3CN(CCCN4CCCC4=O)C[C@@H1]23 CN1N=C2C(=C1C(=O)N[C@]3(CO)CCCN(CC4=NC=C(Br)S4)C3)CSCC2 CO[C@H1](C)CC(=O)N1C[C@H1](C)[C@@H1](NC(=O)C[C@@H1]2CC[C@@H1](C)CO2)C1 C[C@]1(CNC(=O)C2=CSC(C3CC3)=N2)CCN(C(=O)C4=CC=CC(=S)N4O)C1 CCCCCC[C@H1](CC)C(=O)N1CC[C@@H1](OCCNC(=O)C2=CC=C(C#N)[NH1]2)C1 O=C(N[C@@H1]1CC[C@H1]1CNC(=O)[C@@H1]2C[C@H1]2C3=CC=C(F)C=C3F)C=4SC=CC=4F C=CC1(CC(=O)N2CCC(CO)(NC(=O)CCC3=NC(O)=N[NH1]3)CC2)CCC1 O=C(NCC[C@H1]1COCCN1C(=O)C2=C[NH1]C3=CC=C(Cl)C=C23)C4=CC(F)=N[NH1]4 CCC(CC)(CNC(=O)CC1CC(F)C1)NC(=O)CC2CCCCC2 CC1CC(CNC(=NC)NCC2=CSC(C3=CC=C(F)C(F)=C3)=N2)C1 COC[C@@H1]1CCCN(C2=CC=C(S(=O)(=O)NC3([C@H1]4CCCCO4)CC3)C=N2)CC1 CC1(C)C[C@H1](CNC2=NC=CC(N3CCC[C@H1](OC4=CC=CC=C4)C3)=N2)CCO1 CCC1=NC(C(=O)N[C@H1](CC)CNC(=O)C=2N=NN(CC3=CC=CC=C3)C=2C)=CS1 C[C@@H1](CC(=O)N[C@H1](C)C(F)(F)F)C(C)(C)NC(=O)C[C@H1]1COC[C@@H1](C)O1 COC1=CC(C)=CC(OC)=C1[C@@H1]2C[C@H1]2NC(=O)C3CC(OC)C3 CC1=NC2=CC(Cl)=CC(C(=O)NCCOCCNC(=O)[C@H1](F)CC(C)C)=C2[NH1]1 CC(C)CO[C@@H1](C)C(=O)NCC=1C=COC=1C(=O)N[C@@]2(C)CCCC2(C)C COC[C@]1(C(N)=O)CCCN(C2=CC=C(F)C=C2C#N)C1 CN(C)C1=CC(C(=O)NCC[C@H1](O)CNC(=O)C=CSC2=CC=CC=C2)=CC=N1 CP(C)(=O)COCC(=O)NCCC1CC(NC(=O)CSCCC2=CC=CC=C2)C1 O=C1CN(CC2=NC(C=3C=CSC=3)=NN2C4=CC=NC(Cl)=C4)CCN1 O=C(/C=C/C1=COC=N1)NC(C2=CC=CC=C2)C3=CC=CC=C3Br C[C@@H1]1CN(C(=O)CCCCC2=CC=CC(O)=C2)C[C@@H1]1NC(=O)C3=CC=[N+1]([O-1])C=C3 CC[C@@H1]1[C@@H1](C(=O)N[C@H1]2C[C@](C)(NC(=O)C34COC(CC)(C3)C4)C2)CCN1C COC[C@@]1(C(=O)N(C)CC[C@@H1](C)NC(=O)C2=N[NH1]C3=C2CSCC3)C=CCC1 CON(CCC(=O)N(C)C[C@@H1](O)C1CCC1)C(=O)CC2=CC=CC=C2C C[C@H1]1CCN(C(=O)[C@@H1]2CC(=O)N2)C[C@H1]1CNC(=O)C3=CC=NC(F)=C3 CCCN(CCNC(=O)C=1[NH1]C=NC=1CC)C(=O)C2=CSC(O)=N2 CC1=CC=C2C(=C1)C[C@H1](C(=O)NC[C@H1]3CCN(C(=O)C4=CC(Cl)=C(Cl)S4)C3)O2 O=C(CS(=O)(=O)CC1=CC=CS1)N2CCN(C(=O)[C@@]34CCC[C@@H1]3C4)[C@@H1]5CC[C@@H1]52 CCC[C@H1](O)C(=O)N[C@@H1]1[C@@H1](C)CCN(C(=O)C2=CC=C(OC)C(C)=C2)[C@@H1]1C COCC1=CC(F)=CC=C1C2=C[NH1]C(C(=O)NCCC3=CC=CC=N3)=C2 CCN(CCNC(=O)[C@@H1]1C[C@@H1]2C[C@@H1]2C1)C(=O)[C@H1]3COC4=CC=C(Br)C=C4C3 O=C(CN1C(C2=CC(Cl)=CC=N2)=NN=C1N3CCC[C@@H1](CO)C3)N4CCCCC4 O=C(CS(=O)(=O)C1CC1)N[C@H1]2C[C@H1]3C[C@@H1](C2)N(C(=O)C[C@H1]4CC4(Cl)Cl)C3 CC1(C)CCC(C(=O)N2[C@H1](C(=O)N[C@H1](CCO)C3CC3)C[C@@H1]4C[C@@H1]42)CC1 C=C(Br)CN(C)[C@@H1](C(=O)NC(C)(C)C)C1=CC(C)=CC(F)=C1 CC[C@](C)(CNC(=O)[C@@H1](O)CC1CCCC1)NC(=O)CN2CCCC2=O NC1=CC(F)=CC(C(=O)N2C[C@H1]3C[C@]3(CNC(=O)C=4N=NSC=4C(F)F)C2)=C1 CN1[C@H1]2CC[C@H1]1CC(=CC(=O)NC[C@H1]3C[C@@H1](NC(=O)[C@@](C)(O)[C@@H1]4CCOC4)C3)C2 CC1=CN=C(CN(C)C(=O)[C@@H1]2CN(C(=O)[C@@H1](F)C(C)C)C3(CCC3)C2)O1 CC[C@H1](CC(=O)N1CC[C@H1](NC(=O)C2=CN=CC(F)=C2)C3(CCC3)C1)C(C)(C)C CC=1SC(C(=O)NC[C@]2(C)CCC[C@H1]2NC(=O)C3=CC=C4C(=N3)NCC4)=NC=1O CC1=CC(C(=O)N2CC(F)(CNC(=O)C3=NN[C@H1](C(F)(F)F)C3)C2)=C(O)N=C1C CC(C(=O)N1CCC2(CCN(C(=O)[C@H1](CC(C)C)NC(C)=O)C2)CC1)=C3CCC3 CN1CC[C@@H1](NC(=O)CCN(C(=O)CCC2OCCO2)C3CC3)C14CC4 O=C(C=1C=CC2=CC=NN2C=1)N3C[C@H1]4[C@H1](C3)N4C(=O)C5=CC(C6=CC=CO6)=NO5 C[C@H1](CN(C)CC#CC1=CC=C(Cl)C=C1)C(C)(C)C CCN1C=CN=C1C2=CN(CC3(CNC(=O)[C@H1](C)N4CCC4)CC3)N=N2 CN(C(=O)C=CC1=CC=C(C(N)=O)O1)C2CC(NC(=O)CC=3C=NOC=3)C2 O=C(NC[C@@H1]1C[C@@H1]2C[C@@H1]2N1C(=O)[C@H1]3CCCN4N=CC=C43)C=5C=C6N(N=5)CCO6 COC1(OC)CC(C(=O)NC[C@H1]2[C@@H1]3CN(C(=O)C4=CN=C5SC=CC5=C4)C[C@H1]23)C1 CCN1CCCC[C@H1]1CNC(=O)[C@@H1](NC(=O)CC2(C#N)CC2)C(C)(C)C CCCCCNC(=O)N1CCC[C@](O)(CC2=NC(C)=NO2)C1 C[C@H1](O)[C@H1](C)C(=O)N1CC(N(C)C(=O)C[C@]2CCCN2C(=O)OC(C)(C)C)C1 CC1=C(C)C[C@](C)(NS(=O)(=O)C2=CC=C(N[C@H1](CO)C(C)C)C(Cl)=C2)CC1 C=C[C@H1](O)C(=O)N[C@H1](C)CN1CCN(C(=O)C(C)=CC2CCCC2)CC1 CCCN1N=C(C)C=C1C(=O)N2CC3(CN(C(=O)C4=NOC=C4C)C[C@@H1]3CO)C2 CC1=NOC(N)=C1C(=O)NC[C@@H1](CC2CC2)C(=O)N3CC(C)(C(F)(F)F)C3 CC(C)C1=CC=C(C(=O)NC[C@@H1]2C[C@H1]2NC(=O)C3=NC(C4CC4)=CS3)C=N1 CCCN1C=CC=C1C(=O)N(CC2=CC=CC=C2)[C@H1](C)[C@@H1](O)CC CO[C@@H1](C)CCC(=O)NC[C@H1]1CN(C(=O)CC2=CC=C(O)C=N2)CC(C)(C)C1 C#CCOCC(=O)N1CC[C@](O)(CN(C)C(=O)C2CCN([C@H1]3CCSC3)CC2)C1 CC1CCC(OCC(=O)N2[C@H1](C)[C@H1]3C[C@@H1]2[C@H1]3NC(=O)C4=CC=C[NH1]4)CC1 CC[C@H1](COC)C(=O)NCCN(CC1CC1)C(=O)C=2C=N[NH1]C=2 C=C1CC(C(=O)N2C[C@H1]3C[C@H1]2CC[C@@H1]3NC(=O)C4=CC=CC5=C4OC[C@H1]5C)C1 N#CC=1N=CN(CC(=O)N2CCC[C@H1](CCNC(=O)C3(C4CC4)CCC3)C2)N=1 CC=C(C=CC(=O)NC[C@H1]1C[C@H1]1CNC(=O)C2CCN(C3CC3)CC2)CC CC1=CC(NC(=O)[C@@H1]2COCCN2C(=O)C3=CC=CC4=C3CCCC4)=CC(Cl)=N1 O=C(C[C@H1]1CCSC1)N[C@@H1]2CC[C@H1](CNC(=O)C3=C[NH1]C(=O)C=N3)C2 CN1N=C(C(=O)N2CC(C)(NC(=O)C3CC(F)C3)C2)C(Cl)=C1C(F)(F)F COC1=CC=C(C(=O)N2C[C@@H1](OC)C[C@H1]2CNC(=O)[C@H1]3C[C@H1]4CC(=O)[C@@H1]3C4)C=N1 C=C=C[C@@H1](C)C(=O)N[C@@H1]1CN(C(=O)C=2C=NN(CCOC)C=2C)C(C)(C)C1 C#CC1=CC=CC(CC(=O)N[C@@H1]2C[C@@H1](NC(=O)C[C@]3(C)CCOC3)C[C@H1]2O)=C1 C/C=C/CCCNC(=O)[C@H1]1CN(C(=O)C=2C=CSC=2)CC1(C)C CN1C=C(C#N)C=C1C(=O)N2CC[C@@H1](CNC(=O)CC=3SC(O)=NC=3O)C2 CC(C)N1C=CC(=NC(=O)[C@H1](C)[C@@H1]2CCCN(C(=O)CC3=CN=CN=C3O)C2)[NH1]1 CCN1N=NC(C(=O)N2CC(F)(F)C[C@H1]2CNC(=O)C3=CC(Cl)=C(Cl)N3C)=C1C O=C(C=CC1=CC=C(Cl)C(Cl)=C1)NC2=NC=C(Cl)C=C2Cl C[C@H1](C[C@@H1](C)NC(=O)CO[C@@H1]1CCCOC1)NC(=O)C=2C=COC=2Cl CN1C=C(C(=O)NCC2CCN(C(=O)[C@@]3(C)CCCCC3(F)F)CC2)C=CC1=O C[C@]1(CCCCNC(=O)C(=O)N[C@@H1]2CCC=3C=CSC=32)NC(=O)NC1=O CC1=CC(C(=O)N2CC[C@](O)(CCNC(=O)C3CCOCC3(C)C)C2)=CN=C1C CC(C)C[C@H1](C(N)=O)C(=O)N(C)C[C@H1](C)NC(=O)C=1[NH1]N=NC=1C2CC2 CC(C)[C@H1](NC(=O)CC1CCN(CC2=CC=CC=C2)CC1)C(=O)NCCO CCCC1=NC(C(=O)N[C@@](C)(CNC(=O)C2=NN=C(C)C=C2O)C(C)C)=CS1 CCCCC(=O)N1C[C@@H1]2[C@@H1](C[C@H1]2NC(=O)C3=CN(CC4CC(=O)C4)N=N3)C1 CSC1=CC=CC(F)=C1C(=O)N[C@@H1](C)[C@@H1]2CN(C(=O)CN(C)C)CCO2 CCO[C@@H1](C)C=1N=C(C2=CC(Cl)=NC=C2Br)N(C[C@H1]3CCCCO3)N=1 CC[C@H1](CCOC)C(=O)N1CC2(CCC2)C[C@H1]1CNC(=O)CCCC(F)(F)CO O=C(N[C@H1]1CCCCN(CC2=CC=CC3=C2COCC3)C1)C4=CC(F)=CC=C4F O=C(NC1(CNC(=O)[C@H1]2CCCS(=O)(=O)N2)CC1)[C@H1](O)C3=CC=CN=C3 C=CCCC1(C(=O)N2CC[C@](C)(CC(=O)NC(C)(C)[C@H1](O)C(F)F)C2)CC1 C#CC1=C[NH1]N=C1C(=O)N[C@H1](CCC(C)C)C(=O)N[C@H1](C(=O)OC)C2CC2 O=C(C=CC1=C(F)C=CC=C1F)N[C@@H1]2CC23CC(NC(=O)C4=NNC(=O)CC4)C3 COC(=O)[C@](C)(O)CNC(=O)C[C@H1]1C[C@H1](NC(=O)CC2=NON=C2C)C1 CN1CCO[C@H1](C(=O)N[C@H1]2CCC[C@@H1]2NC(=O)C3=CN(C)C(=O)C4=CN=CN34)C1 C=CCO[C@@H1](C)C(=O)N1CCN(C(=O)C2(COC)CC2)C[C@@H1]1CC(C)(C)C CC[C@@H1]1CCN(C(=O)C(=O)NCCN2C(=O)NC(C)(C)C2=O)[C@H1]1C CC=C(CC)C(=O)N1C[C@@H1](NC(=O)[C@@]2(COC)C=CCC2)[C@H1](C=3C=NN(C)C=3)C1 CC[C@@H1]1CCC[C@]1(C)C(=O)N2C[C@H1]3C[C@@H1]2[C@H1]3NC(=O)C4=CC=CC5=NC=C(C)N45 C[C@@H1](CNC(=O)C[C@H1]1OCCC1(C)C)CN(C)C(=O)C=2C=C[NH1]C(=N)N=2 C=C(C(=O)NCC1=CC=C(NC(=O)OC(C)(C)C)C=C1C2OCCO2)C(F)(F)F C[C@@H1](CN(C)C(=O)C1=CN(C)C(=O)C=N1)NC(=O)CN2CCN3N=CC=C32 COC1=CC(C(=O)N2C[C@@H1](C)C[C@@H1](NC(=O)C3=CN=C[NH1]3)C2)=C(Cl)C=C1Cl C=C(Cl)CCC(=O)N1C[C@H1]2[C@H1](CNC(=O)[C@@H1]3CCC(C)=C(C)C3)C[C@H1]2C1 CC(C)(C)OC(=O)N1CCOCC(CS(=O)(=O)N(CC#N)CC2CC2)C1 CSCCC(=O)N[C@H1]1CCN(C(=O)C2CC(C)(C)SC(C)(C)C2)C13CCC3 C[C@@H1]1CCCCN1C(=O)[C@H1]2CCCCN2C(=O)C3(NC(N)=O)CC3 C[C@@H1](NC(=O)CCCNC(N)=O)[C@@H1](C)NC(=O)C1=CC=C(C2=CSN=N2)C=C1 C=CC[C@@H1](C)C(=O)NCC(C)(C)CNC(=O)[C@H1]1C[C@H1](F)CN1C(=O)OC(C)(C)C CCC(CC)[C@@H1](F)C(=O)NC[C@@](F)(C(=O)NCC1=NC=CS1)C(C)C O=C(CC[C@H1]1CC1)N2CC3(CNC(=O)[C@@H1](O)C=4C=CSC=4)CCC2CC3 NC1=CSN=C1C(=O)N2CCSC[C@H1]2CCNC(=O)[C@@H1]3C[C@H1]4CC[C@H1]3O4 C#CCCC(=O)NC1=CC=CC=C1C2=C(C)N(C)C(=O)N2CC3=CC(C)=CC(F)=C3 CC[C@@H1](C(=O)NCC1(C(=O)O)CC2(CCC2)C1)[C@@H1](C)O CC(C)N1CCC[C@H1](C(=O)N(C)C[C@@H1](C)N(C)C(=O)CCSC2=CC=CC=C2)C1 C[C@H1]1C[C@@H1](C(=O)NC[C@]2(F)C[C@H1](CO)C2)CCN1C(=O)C3=CC(=O)N(C)C=N3 CCC(=O)NC1=CC=CC(C(=O)NC23CCC(NC(=O)C=4C=CON=4)(CC2)C3)=C1 N#CC1=CC=CC(CC(=O)N2CC=C[C@H1](NC(=O)[C@@H1]3C[C@@H1]3C(F)(F)F)C2)=C1 CCC=1N=NSC=1C(=O)N[C@@H1]2CCCC23CCN(C(=O)[C@@H1](F)OC)CC3 C[C@H1]1CN2CCN1[C@H1](C(=O)NC34CC(NC(=O)C5=CN6C=CN=C6C=N5)(C3)C4)C2 NS(=O)(=O)C1=N[NH1]C=C1C(=O)N2C[C@H1](C3=CC=C(F)C=C3)[C@@H1](CO)C2 C#CC1=CC(Cl)=CC(C(=O)N(C)CCNC(=O)[C@H1]2C[C@@H1](C#N)C2)=C1 O=C(C[C@@H1]1COCCO1)NC[C@H1]2[C@@H1]3C[C@H1]2CN3C(=O)C4=CC(F)=C(F)C(O)=C4F C=CCCCCCC(=O)N1CCO[C@H1](C(=O)NCC[C@@](C)(O)C2CC2)C1 CC1=CC(C(=O)N2CCC[C@@](C)(CNC(=O)[C@@]3(C)CC(C4CC4)=NO3)C2)=CN=N1 CCC1CC(CN=C2[NH1]C(=NCCOC3=CC=CC=C3C)C4=CC=CC=C4[NH1]2)C1 O=C(N[C@@H1]1C[C@H1]2C[C@H1]1CN2C(=O)C3=C(Cl)CCOC3)C4=CC(Br)=N[NH1]4 C#CCSCC(=O)N[C@H1]1CN(C(=O)C2CC3=CSC=C3C2)C[C@@H1]1C CCOCC1(C(=O)N[C@@H1]2CN(C(=O)CC[C@@H1](C)OC)C[C@H1]2OC)CC1 CN(C)C[C@@H1]1CCN(C2=NC(=NCC3=CC=NC(Br)=C3)[NH1]C=4C=C[NH1]C2=4)C1 COC(=O)C1=COC=2C=C(C(=O)NC[C@@H1]3CCCO[C@@H1]3CN)[NH1]C1=2 C[C@@H1](CC1CCC1)C(=O)N2CCC3(CCC3)[C@H1](CNC(=O)C4=CN=CC(Cl)=C4)C2 C[C@@H1]1COCCN1CCNC(=O)CCCCN(C)C(=O)[C@]23CSC[C@H1]2C3 CC1=CC(Cl)=C(Cl)C=C1CN2CCCC[C@@H1]2C(=O)NC3=CC=CC=4[NH1]N=CC3=4 O=C(NCC1CCN(C(=O)C2CC2)CC1)[C@@H1]3C[C@H1]3C4=CC=CC=C4Cl C[C@H1]1CC(C(=O)NC[C@@]2(C)CN(C(=O)C3=CC=C(N(C)C)N=C3)C(C)(C)C2)=NO1 CN=C1[NH1]C(C(=O)N2CCCO[C@@H1](CNC(=O)C3=CC=4C=N[NH1]C=4C=N3)C2)=CS1 CC=1N=COC=1C(=O)N2CC(C3CN(C(=O)C=4SC=NC=4C(C)C)C3)C2 CC(C)C[C@H1](ONC(=O)[C@H1](C)C=1C=NN(C)C=1)C(=O)NC[C@H1]2C[C@H1]3CC[C@H1]2C3 CC(C)(C)N1CC[C@@H1]1C(=O)N(CCC(=O)N2C[C@H1](O)[C@H1](O)CO2)C3CC3 C[C@@H1](C(=O)N[C@H1](CNC(=O)C=1C=C(C2=CC=CS2)ON=1)C(C)(C)C)N3C=NN=N3 CC1=CC=CC(CNC(=O)[C@@H1]2C[C@H1](N(C)C)CN2)=C1Cl CSC1=CC=CC=C1C(=O)NCCOCCCNC(=O)CCS(C)(=O)=O CCCC1=NC=C(C(=O)N[C@@H1](C)[C@@H1]2CCN(C(=O)C3=N[NH1]C(CC)=C3C)C2)S1 CC1=NC=CN=C1C(=O)N[C@@H1]2CN(C(=O)[C@@H1]3C[C@]3(C)C(C)C)CC2(C)C CC1=CC(Cl)=NC(NC(=O)C2=CN=C3C(=C2)CCN(C(=O)C4=CC=CC=C4)C3)=C1 CC(C)[C@](C)(O)C(=O)N1CC(CCNC(=O)CCCC2=NN=CN2C)C1 CC(C)(C)[C@@H1](CO)NC(=O)[C@H1]1CCC[C@H1](NCC2=C[NH1]C3=CC=CC(C#N)=C23)C1 N=C1C=CC(C(=O)N2C[C@@H1]3[C@@H1]4CC[C@@H1](CN4C(=O)C=5C=CSC=5)[C@H1]3C2)=C(Cl)[NH1]1 CN(C)[C@@H1](C(=O)N1CC(CCNC(=O)C2=CC=C(Cl)N=C2)C1)C3=CN=CN3C CC1=CC=CC(C(=O)NC[C@H1](CO)NC(=O)[C@H1]2COC3=CC(Cl)=CC=C3O2)=C1F CC[C@@H1]1CN(C(=O)[C@H1](F)CNC(=O)OC(C)(C)C)CCN1C(=O)C=2C=CN(C)C=2 COC(=O)NC1=CC(C(=O)N2CC[C@H1](CCNC(=O)CC[C@H1](C)N(C)C)C2)=CC=C1 O=S(=O)(NCC1=CC=CC=2C=COC1=2)C3=CC=C(N[C@@H1]4CCCC[C@H1]4O)C(F)=C3 CC1=CC(CCC(=O)N[C@@]2(C3CC3)CCN(C(=O)CCCCC#N)C2)=N[NH1]1 CC[C@@H1](C(=O)N(C)C[C@H1]1CN(C(=O)C2=N[NH1]C=C2C)CCO1)N3C=NC(C#N)=N3 CC[C@@H1](CN(CC)C(=O)[C@H1](O)C1=CCCCC1)NC(=O)C2=CN(C(C)C)C=N2 CC(C)=C(C)CC(=O)N(C)[C@@H1]1CCCC[C@@H1]1NC(=O)CC2C[C@@H1]3C[C@H1]3C2 CC[C@H1]1CCN(C2=CC(N3CCC(C[C@@H1](C)O)CC3)=NC(C(C)C)=N2)CCO1 CC1=CC=CC=C1COCC(=O)N2CCCCC[C@H1]2CNC(=O)C3=CC(Cl)=CS3 C=C[C@@H1](CC)C(=O)N1CCOCC(C)(CNC(=O)C2=C[C@@](C)(CC)C2)C1 COC1=NC=C(C(=O)N(C)CC2CN(C(=O)C=3SN=C(O)C=3Cl)C2)S1 C#CCCCOCC(=O)NCC[C@H1]1CCN(C(=O)C=2C=CN(C)C=2)[C@H1](C)C1 CC(C)(C)C(=O)N1CC(O)(CCNC(=O)C=2C=C3N(N=2)CCCC3)C1 CC[C@H1]1C[C@@H1]1C(=O)N(CCNC(=O)CCC=2C=CN(C)C=2)C(C)C CC1(C)CCN(C(=O)[C@@H1]2COCC[C@H1]2NC(=O)[C@H1]3CCCC(=O)N3)C[C@H1]1CO CCO[C@@H1]1C[C@H1]1C(=O)N2CCN(C(=O)CN(C)C(=O)C=3C=CSC=3COC)CC2 CC[C@@H1](CC(=O)NC[C@@H1]1CN(C)CCN1C(=O)C(Br)=C(C)C)OC N#CC1=NC=CC=C1C(=O)N2CC[C@H1](CNC(=O)COC=3C=CON=3)C24CC4 C[C@@H1](NC(=O)C(F)(F)CN1CCCC1)[C@@H1]2CCCN(C(=O)C3(N=[N+1]=[N-1])CC3)C2 C1CC[C@H1](C(=O)NC[C@@H1]2CN(C(=O)C3(CF)CCC(F)(F)CC3)CC2(C)C)C1 CCC1=CC=CC=C1C(=O)NC[C@H1]2CO[C@H1](CNC(=O)CS(C)(=O)=O)C2 CCC(CC)CC(=O)NC[C@@H1]1CN(C(=O)C(C)(C)C=2C=NSC=2)CC3(CCC3)O1 CCOC(=O)[C@@H1](CC(C)C)N(C)C(=O)[C@H1]1CC(=O)N(C)C1 CCCCC(=O)N1CC=C[C@@H1]1CNC(=O)C2=CC=C(F)C(F)=C2 CCSC1=CN=CC(C(=O)N2CC[C@@H1]3CN(C(=O)CCN(C)C(C)=O)C[C@@H1]32)=N1 C=C1C[C@@H1]2CCC[C@H1](C1)N2C(=O)C3=N[NH1]C=C3CNC(=O)CSCC(F)F C=C(Cl)CCC(=O)N[C@H1]1[C@H1](C)N(C2=NC3=CC(C)=CC=C3O2)CC[C@H1]1C COC1=CC=C(Br)C(N2N=C([C@@H1](C)C3CC3)N=C2[C@@H1]4CC(C5CC5)=NO4)=C1 CC1(C)CCN(C(=O)CN2CCCCC2)C[C@@H1]1NC(=O)[C@]34C[C@@H1]5C[C@@H1]3[C@H1]4[C@H1]5O CCCC[C@@H1](C=1N=C2C=C(Cl)C(C)=NN2N=1)NC(=O)[C@H1](O)CC3=CN=C[NH1]3 O=C(CC12COC(CF)(C1)C2)NCCC3(O)CN(C(=O)CC4=CC=CS4)C3 CC1=CC=C(F)C=C1C(=O)C(=O)NC[C@@H1]2C[C@H1]3CC[C@@H1]2N3C(=O)C4=CC(Cl)=NO4 COC1(C(=O)N2C[C@@H1](C)C[C@H1](NC(=O)C3=CC=CC4=NN=CN34)C2)CCCCC1 CC1=CC=C(OCC(=O)NC[C@@H1](C)NC(=O)CCC2=CSC=N2)C=C1 CN(CC(=O)N[C@H1]1CCSC12CN(C(=O)C3=CC=C(N)C=C3Cl)C2)[C@@H1]4CCSC4 COCC1(NC(=O)[C@@H1](C)C#N)CN(C(=O)CC2(C(F)(F)F)CCC2)C1 C#CC[C@H1](O)C(=O)N[C@H1]1COC[C@H1]1C(=O)N2CCC=3SC=CC=3C2 CCN(C(=O)[C@@H1]1CCC[C@@H1](NC(=O)[C@@H1](C)[C@H1](O)C(C)C)C1)C23CC(C2)C3 N=C1[NH1]C=C(C2CCN(C3=NC=NC4=C3N=CN4[C@@H1]5C[C@H1]5CO)CC2)[NH1]1 COC1=CC=C(C2=CC=C(CNC(=O)NC[C@@H1]3CC3(C)C)N=C2)C(F)=C1 CCCCCN(C)[C@H1](C(=O)NCCOCC)C1=NC=C(C2OCCO2)S1 C[C@H1]1NC2=C(C=CC=C2C(=O)N[C@H1](CO)C3=CC=C(Cl)C=C3C(F)(F)F)NC1=O CC[C@H1](CC(=O)N[C@@]1(C)CCCN(C(=O)C2(Br)CC2)C1)C(C)C CC(C)CC(=O)N1CC(C)(NC(=O)CCC(C)(C)[N+1](=O)[O-1])C1 COCC=1C=CSC=1C(=O)N2CC3(CCN3C(=O)C[C@@H1]4CCC5=CC=CC=C54)C2 CN(CC[C@@H1](NC(=O)[C@@H1]1CC[C@H1]2C[C@@H1]1CO2)C3=CC=CS3)C(=O)CC=4C=C[NH1]C=4 CC1(O)CCC(C(=O)NC2CC[C@H1](CC(=O)NCCO[C@H1]3CCOC3)C2)CC1 COC1=CC=CC([C@H1](OC)C(=O)N2CC3(C2)CN(C4=NN=C(C(C)C)O4)C3)=C1 CCC1=CC=C(CNC(=O)C(C)(C)NC(=O)CC2CC(F)(F)C2)N=C1 COC1=CC=CC(N2CCN(C3=CC=NC(NCC=4N=CN(C)N=4)=N3)CC2)=C1 COC=1C=C(CC(=O)N2CC[C@H1](CNC(=O)CO[C@H1]3CCCOC3)[C@H1](C)C2)ON=1 C[C@H1]1CN(C(=O)C2=CC=CC(OC(F)F)=C2)CC[C@H1]1NC(=O)C3=CC=NC(I)=C3 CCC[C@H1](NC(=O)C1(C#N)CC=CC1)C(=O)N[C@H1](C)C2=CN=CC=N2 C[C@@H1]1C[C@@H1](NC(=O)C=C2C=CC=CC2)CN(C(=O)[C@H1](C)C(C)(C)C)C1 C[C@H1]1C(C(=O)N(C)CCCC(=O)NCC[C@@H1]2CC=CCC2)=NO[C@@H1]1C COC1(CCNC(=O)C2=CC(F)=C3C=CC=CC3=C2)CN(C(=O)C=CC4CC4)C1 CNC(=O)[C@H1]1CCC[C@H1]1NC(=O)[C@@]2(C)CCCN2C(=O)[C@H1]3COCC[C@H1]3C CCCCSCC(=O)N(CC)C1CCN(C(=O)C2=CN=C3SC=CN23)CC1 COC1=CC=C(F)C=C1CC(=O)N2CCN(C(=O)C(Br)=C(C)C)[C@H1](CF)C2 C[C@H1]1CCC[C@H1](C(=O)NCC2=CC=C([C@H1](C)NC(=O)C3=CC(Cl)=C[NH1]3)C=C2)CC1 CC(C)OC1=CC=CC(C(=O)N2CCC[C@@]2(C)CNC(=O)C3=COCCC3)=C1Cl CN1C=CC(CC(=O)N2C[C@H1]3[C@H1]4CC[C@@H1]([C@H1]3C2)N(CC5=CC=C(Cl)S5)C4)=N1 CSC1=C(C(=O)N[C@@H1]2CC23CC(NC(=O)CC=4C=CN(C)N=4)C3)C=NN1C CC=CCC(=O)NC1CC(CCNC(=O)C=2N=C[NH1]C=2C(C)(C)C)C1 O=C(C1=CC=2C=CSC=2S1)N3CCC[C@@H1]4CN(C5=NC=CC(CO)=N5)CC[C@@H1]43 O=C1O[C@H1]2CC[C@@H1]1CN(C(=O)CCN=C3C=C[NH1]C=C3)C2 O=C(N[C@H1]1CCCC12CCNCC2)C3CCC4(CC3)CC4 O=C(N[C@H1](CNC(=O)C(F)(F)C1=CC=CC=C1Cl)C2CCCC2)C3=CC=C(F)O3 CC(C)CCN(CCC(C)C)C(=O)[C@@H1](C)C1=CC=CC([N+1](=O)[O-1])=C1 CO[C@H1]1C[C@@H1](C)CN(C(=O)[C@@H1](F)CC(C)(C)NC(=O)COCCF)C1 O=C(N1CC(C2=CC=C(Br)S2)C1)C3(N4C=C(COCCO)N=N4)CCOCC3 COC1=CC=C(Br)C=C1CN2CCC[C@H1]2C3=CC=CS3 CCNC(=O)CC(=O)N1C[C@@H1](NC(=O)C2CC3=CSC=C3C2)C[C@]14CCCOC4 CC[C@H1](C(=O)N[C@H1](C)C[C@H1](C)NC(=O)[C@@H1]1CSC(C)=N1)N2CCCC2=O CC[C@H1](C#N)C(=O)N[C@@H1](CC(=O)N[C@@H1]1CCN2N=CN=C2C1)C(F)(F)F NC(=O)CCC(=O)N[C@@]12CCCN(C(=O)CCCS(N)(=O)=O)C[C@H1]1C2 COCC1(NC(=O)C2=CC=C(Cl)C(N)=C2Cl)CN(C(=O)COC3(C)CCCC3)C1 CN1N=C(C(=O)N[C@@]2(CF)CCN(C(=O)C=CCOC3CCOCC3)C2)C=C1Cl C[C@@]1([C@@H1]2CCCCN2C(=O)N[C@H1]3C[C@@H1]3C4=CC=CC=C4)CCOC1 CCOC1=CN=CC(C(=O)N[C@@H1]2CCC[C@]23CCN(C(=O)C4=COCCO4)C3)=C1 O=C([C@@H1]1CC(=O)N(C2CC2)C1)N3CC[C@@H1](N4C=CN=C4)C3 CC=1C=C(C(=O)NCC(=O)N(C)CC[C@H1](C)NC(=O)[C@@H1](C)S(C)(=O)=O)N(C)N=1 CCS(=O)(=O)N1C[C@@H1]2CN(C(=O)C3=CC=C(P(C)(C)=O)C=C3)C[C@H1]21 CN1CC[C@H1](C(=O)NC[C@H1]2CCN(CC3=C(Cl)C=CC=C3[N+1](=O)[O-1])C2)C1 O=C(NC[C@@H1](NC(=O)C12CCC(C1)C2)C3CC3)C4=C(F)C=C(F)C=C4Cl C=C[C@H1](C)NC(=NCCC[C@H1]1CCOC1)NCC2=CC=C(F)C3=CC=CC=C23 CN(C[C@@H1]1CN(C(=O)[C@@H1]2CSCC(=O)N2)CCO1)C(=O)CNC(=O)C(C)(C)C CN(C)S(=O)(=O)N1CC[C@@]2(C[C@H1](NS(=O)(=O)C3=CC(F)=C(Br)C=C3F)CO2)C1 CCC1=CSC(C(F)(F)C(=O)N2C[C@@H1](O)[C@H1](NC(=O)[C@@H1](O)CN3C=NC=N3)C2)=N1 O=C(N[C@H1]1CCOC2(CCN(C(=O)[C@@H1]3CC4=NC=CN4C3)CC2)C1)C5=CC=NS5 C=CCC1(C(=O)N2[C@H1]3CC[C@H1]2[C@@H1](CNC(=O)C(=O)NC4CC4)C3)CC1 CCCC[C@@H1](C(=O)N[C@H1]1C=CCN(C(=O)C2=CN=C3[NH1]C=NC3=C2)C1)C(C)C C=C[C@@H1](O)C(=O)N1CCC[C@@H1]1C2CCN(C(=O)C3=CC=CC=4OC(O)=NC3=4)CC2 CCOC1=CC=C(CNC=2C=C(C(=O)NC3CN(S(C)(=O)=O)C3)N(C)C=2C)C=C1 CC(C)C[C@@H1](CNC(=O)[C@H1]1CC2=NC=CN2C1)C(=O)NCC3=CC=CC=C3F CCOC[C@@H1](C)C(=O)N[C@@H1](C)CNC(=O)C1=N[NH1]C2=C1C(=O)CCC2 CC[C@H1](C)[C@@H1](C)N(C1CC1)[C@H1](C(=O)NC2COC2)C3=CC=C(C4CCC4)N=C3 CNC(=O)[C@@H1]1CCC[C@H1]1NC(=O)C2=CN3C=C(C)C=CC3=N2 CC(=CC(=O)N1CCN(C(=O)[C@@H1]2CC2(C)C)[C@@H1](CO)C1)C3=CC=C(F)C=C3F CNN=CCC(=O)N=C(COC(=O)CC1=CC=CC(O[C@@H1]2CCNC(=O)C2)=C1)[NH1]C CC(C)(F)CCC(=O)NC[C@@]1(O)CCCN(C(=O)CN2CCC(C(N)=O)CC2)C1 CCSCC(=O)NCC1(O)CCN(C(=O)[C@H1](C)CCC2=CC=CC=C2F)CC1 CC=1C=CN(CC(=O)N2CCN(C(=O)C[C@@H1](C)[C@H1]3CCCO3)CC4(CC4)C2)C=1 O=C(CC1=C(Cl)C=CC=C1I)OCC(=O)C2=CC=CC(OC(F)F)=C2 C=CCC1(C(=O)N[C@@H1]2CCOC[C@@H1]2C(=O)N(C)[C@@H1](C)CO)CCC1 CCC1=CC=CC(C(=O)N2CCC[C@](CO)(CNC(=O)C3=CC(OC)=NO3)C2)=C1 CC1=CC(C(=O)N2CCC3(CC2)C[C@H1](NC(=O)[C@H1](C)CC(C)(C)C)CO3)=NN1C C=C1CCN(C2=CC=C(S(=O)(=O)N3CCC[C@@H1](NC(C)=O)C3)C=N2)C1 C=CC[C@]1(NC(=O)C23CC(C)(C2)C3)CCN(C(=O)C4(N(C)C)CCCC4)C1 CC(C)N(CCCNC(=O)C1=CC=C2C=CC=C(Cl)C2=N1)C(=O)[C@@H1](C)NC(N)=O C#CC1(C(=O)NC[C@@H1](C(=O)N(C)[C@@H1]2C[C@@H1]2C)N(C)C)CCCCC1 CCN1N=NC(C)=C1C(=O)NC[C@@H1](NC(=O)[C@@H1]2CCC3(CC3)C2)C4=CC=CC=C4 O=C(C=C1CCC1)NC2CC([C@H1](F)C(=O)N3CCC[C@H1](F)C3)C2 CCCC[C@@H1](CC)C(=O)NC[C@H1]1CN(C(=O)CCOCCOCCCO)CCO1 C#CC1=CC=C(C(=O)NC[C@@H1]2CN(C(=O)[C@H1](C)N3C=CC=N3)CC2(C)C)N=C1 COC1=CC=C(C2=CN3C=NC(C(=O)N[C@@H1](C)C#N)=C3S2)C(O)=C1OC C=CCC(C)(C)CCNC(=O)C1=CC=NC(CNC(=O)C[C@@H1]2CCCOC2)=C1 COC1=CC=C(Cl)C(F)=C1C(=O)N2CCN(C(=O)CCCN(C)C)[C@H1](C(F)F)C2 CCC(F)(F)C(C)(C)C(=O)N1CCC(N(C)C(=O)C2=NC=C(C)C=N2)CC1 C[C@]1(C(=O)N2CC(OC3CCN(C(=O)[C@H1](F)C4CCOCC4)CC3)C2)CCCO1 CC=1C=CSC=1CC(=O)N[C@H1](C)C2(C(=O)NC[C@@H1]3CCCC34CC4)CC2 CN1N=C2C(=C1C(=O)N3CCC=4SC(C(=O)NC5=NC=CC=C5F)=CC=4C3)CC2 COCC[C@H1](NC(=O)CCC1OCCO1)C(=O)NC[C@@H1]2CCSC2 CC12CC(C(=O)N3CCC[C@H1](NC(=O)C4=C(C)N=NN4C)C3)(CCO1)C2 CCC[C@H1]1CN(C(=O)[C@H1](F)C(C)(C)O)C[C@@H1]1C(=O)N2CC[C@@H1]2[C@@H1](C)O CCC=CC(=O)N1C[C@@H1](CO)C2(CCN(C(=O)C3CC4(CCOC4)C3)CC2)C1 CC1=CC(C(=O)N2CC[C@H1](CCNC(=O)C3=CC=NN=C3NC(C)C)C2)=CC=N1 COCC[C@@H1](C)C(=O)N1CC2(C[C@@H1](NC(=O)C3=C(C)CCCC3)CO2)C1 COC(=O)CCCONC(=O)CC1=CCN(C(=O)[C@@H1]2CC[C@@H1](N=[N+1]=[N-1])C2)CC1 CN(CCC1=CC=C(OC(F)F)C=C1)CC2=CC=C(N(C)C)C=C2Cl CC[C@H1](CNC(=O)CCC1=CC(Br)=CC=C1Cl)NC(=O)[C@H1]2C[C@H1]2C CO[C@H1](C(=O)NC[C@]1(F)CCCN(C(=O)C2=CC([N+1](=O)[O-1])=C[NH1]2)C1)C(C)C CCN1N=C(C)C(CNC(=O)C[C@H1]2CCCN(C(=O)C=3[NH1]N=NC=3C)C2)=N1 CN(CC(=O)NCC1(C2CCC2)CCN(C(=O)COCC3CC3)CC1)C(N)=O CO[C@@H1]1CC[C@@]2(C(=O)N[C@H1](C)C[C@@H1](C)NC(=O)CC(F)F)C[C@H1]12 CC1=CSC(CCC(=O)NC2[C@H1]3C[C@H1]2CN(C(=O)[C@H1](C)OCC(F)(F)F)C3)=N1 CC1=NC=CN1CCC(=O)N2CC[C@H1](C)[C@@H1]2C(=O)N[C@H1](C)CCF CC1(C)OCC[C@H1]1CC(=O)N2CC[C@@H1](F)[C@@H1](NC(=O)C3=COC(CO)=C3)C2 O=C(COCCF)N[C@]1(C2CC2)CCN(C(=O)C3=CC=CC4=NC=CN34)C1 CC1=CC(Cl)=CC(C)=C1OCC(=O)N2CCC[C@H1](CNC(=O)CC3CC(C)C3)C2 CN(C(=O)/C=C/[C@@H1]1CCCN1C)C2CCN(C(=O)C3=CN=C(S)N3C4CC4)CC2 CC(C)[C@](C)(CNC(=O)CC(=O)NCC(F)(F)F)NC(=O)C1=CC=CC=C1 O=C(CN1C[C@H1]2CNC[C@H1]1C23N=N3)NC4=CC=CC(C5=CC=C(F)C=C5)=C4 CC(C)CN(C(=O)C1(F)CCN(C(=O)CSCC(F)F)CC1)C2CC2 CC(C)(C)OCC(=O)NCC12CC(NC(=O)C3=CC4=NC=CN=C4C=C3F)(C1)C2 COC1=CN=C(C(=O)NC2CC(CCNC(=O)C(C)(C)CNC(C)=O)C2)C=N1 CC1=CC(C=CC(=O)N2CC[C@H1](N(C)C(=O)C=CI)[C@@H1](C)C2)=CC=C1F CCC(CC)(CNC1=NC=C2C(=N1)COC2)NC(=O)C3=CSC=C3C C=C[C@](C)(CC)C(=O)NCCN1CCCN(C(=O)C=2C=C(CO)OC=2C)CC1 CCCN1N=C(C)C=C1C(=O)NCCN2C=CC(C(=O)N3CC(C)(C(N)=O)C3)=C2 CCN(CC)[C@@H1]1CCN(C(=O)C2=NC(NCC3=CC4=NC=CC=C4[NH1]3)=CN2C)C1 CNC(=O)CCC(=O)N1CC2(CC2)C[C@@H1]1CNC(=O)C3=CC=C(C(C)C)N=C3C NS(=O)(=O)C1(C(=O)N[C@@H1]2CCC[C@H1]2NC(=O)C[C@@]3(O)CCOC3)CC1 COCCCCCCNC(=O)[C@@H1]1CCN(C(=O)[C@]2(C)CCO[C@H1](C)C2)O1 C#C[C@H1](C)N1CCN(C(=O)[C@@H1]2CCCN(C(=O)C=3SC=CC=3Cl)C2)CC1 CC(C)N1C=CN=C1C(=O)N2CC[C@@H1](CNC(=O)CCOC3=CC=C(N)C=C3)C2 CC1=C(Cl)C=C(F)C(OC(=O)C(C)(C)[C@@H1](C)NC(=O)C2=CC=CC=C2)=C1Cl CO[C@H1](CO)C(=O)N1C[C@@H1](C(=O)N2CC3(CCN(C)CC3)C2)CC1(C)C C[C@H1](CC=1C=NN(C)C=1)C(=O)NC[C@H1]2[C@@H1]3CN(C(=O)CCN(C)S(C)(=O)=O)C[C@H1]23 C#CCCCC(=O)N[C@H1]1C[C@@H1](CCNC(=O)COC2=CC(Cl)=CC=C2Cl)C1 C[C@@]12CC[C@@H1](CN1CCC(=O)NCCC3=CC=CC=C3)C2 CC1=CC(=O)N(CCC(=O)NC[C@@H1](O)CNC(=O)[C@@H1]2CC2(C)C)C=N1 COC(=O)[C@@H1](CC1=CN(CCCF)N=N1)NC(=O)C2=NC=C(C)C=C2OC CCN=C1[NH1]C(C(=O)N[C@H1]2C[C@@H1](CCNC(=O)[C@H1]3OCCO[C@H1]3C)C2)=CS1 CC[C@H1](C)N1N=CC=C1C(=O)N(C)C[C@H1](C)CNC(=O)C2=CC(F)=CN=C2OC C[C@@H1](CC1=CC=CO1)C(=O)N2C[C@H1]3[C@@H1](C2)N3C(=O)CC4=CN=CN=C4 CCC[C@H1](O)CC(=O)N[C@H1](CN=C1C=C(C(N)=O)N=C(Cl)[NH1]1)C2CCCCC2 CCC(=CC(=O)N1CCC(F)(CNC(=O)C=2SC([C@@H1](C)OC)=NC=2C)CC1)CC CCCCC[C@H1](O)C(=O)NC[C@H1]1CCCCN(C(=O)C2CCCCCC2)C1 COC1=CC=CC(I)=C1C(=O)N[C@H1]2CCN(C(=O)CC3(O)CCC3)C[C@@H1]2F C=CCN1C=C(C(=O)NCCOC2CN(C(=O)C=3C(C)=NOC=3C(C)C)C2)N=N1 CC[C@H1](C(=O)N[C@@H1](C)C1(O)CN(C(=O)CC(=O)OC)C1)C2=CC=C(Cl)C=C2 CC(C)[C@H1](C)N(C)C(=O)C1(NC(=O)CCC2OCCO2)CC(CO)C1 CNC=1SC=NC=1C(=O)NC[C@@]2(C)CCCN(C(=O)C(N)=O)C2 COC1=CC=C(C(N)=O)C=C1C(=O)N2CCN(C(=O)[C@H1]3CC34CC4)C[C@@H1]2CF O=C(CC1=CN=C[NH1]1)N[C@]23C[C@H1]2CN(C(=O)C4(C(=O)NC5CC5)CC4)C3 C[C@H1](C(=O)N[C@H1]1CN(C(=O)CCS(C)(=O)=O)CCC1(C)C)C=2C=CSC=2 CC1=NC2=CC=CC=C2C=C1C(=O)N3C[C@H1]4CC[C@H1]3CN4C(=O)[C@@]5(O)CCOC5 COC1=CC=C([C@H1]2CSCCN2C(=O)C3=CC=C(C#CC4CC4)C=C3)C=C1 C[C@@H1]1CN(C(=O)CCCC2CC2)C[C@H1]1CNC(=O)C3=C[C@H1]4CCC[C@@H1]34 CN1N=NN=C1SCC(=O)N2CC[C@](C)(CNC(=O)[C@@H1](CC(F)F)C3CCC3)C2 O=C(COC(F)F)NC=1SC=C(C2=CC=CC=C2)C=1C(=O)O COCC[C@@H1](CNC(=O)CNC(=O)CCC(C)C)NC(=O)CCC1=NC=C(C)[NH1]1 COCC=1N=N[NH1]C=1C(=O)N2CCC[C@@H1](N(C)C(=O)C=CC3=NC(C)=C(C)[NH1]3)C2 C[C@H1](CCC(=O)N1CC[C@@H1]([C@H1](C)C(=O)N2C[C@@H1]3CC[C@H1](C2)C3O)C1)CN(C)C C[C@@H1]1OCC[C@H1]1C(=O)N2CC[C@H1]2CNC(=O)CC3CCN(C)CC3 CCC1=NC(C)=NC=C1C(=O)N2CCC[C@H1](CNC(=O)C(N)=O)CC2 CC(C)=CCC[C@H1](C)CC(=O)N(C)C[C@@H1](O)CNC(=O)C=1C=CN(C)N=1 CC1(C)CC[C@H1](NC(=O)C2=CC=CC=C2)[C@H1](CNC(=O)CCP(C)(C)=O)C1 CC=C(C)C(=O)N1CC2=NC=CN2C[C@H1](NC(=O)[C@@H1](O)CSC)C1 C[C@H1](OCCN(C)C)C(=O)NCC(C)(C)CCNC(=O)[C@H1]1CCS1(=O)=O CCNC(=O)[C@H1](COCC)N1C=C(CCS(N)(=O)=O)N=N1 O=C(C1CCCCC1)N2CCC[C@H1](N(CC3=CC=CC=C3)C(=O)COC4CC4)C2 CCN1CCC[C@H1]1C(=O)N(C)C2CCC(NC(=O)C3=NC(Cl)=CC=C3F)CC2 CC=CC(=O)N1CC[C@@H1](NC(=O)CCC(=O)OC(C)(C)C)[C@@H1](C)C1 C=C=C[C@@H1](C)C(=O)NC[C@@H1]1CCN(C(=O)CCCN2C=NC=N2)C1 CC1=C(C(=O)N2CCOC3(COC3)C2)[C@H1](C(F)F)N(C4=NC=CS4)C1 CC1=NN(CC(=O)N[C@@]2(CF)CCN(C(=O)[C@@H1]3CCCN3N=O)C2)C=C1Cl CN1N=CC=C1[C@H1](NC(=O)CC2=CSC=N2)C(=O)NC3=CC=CC=C3 C[C@H1](NC(=O)C1=CN=NC(O)=C1)[C@H1]2CCCN2C(=O)C3=NC4=C(S3)COCC4 CC1(C)CN(C(=O)C2=CC(F)=C(Br)C=C2Cl)C[C@@H1]1NC(=O)[C@H1]3C=CCC3 CC(=O)NCC(C)(C)C(=O)N1CC[C@H1]([C@H1]2CCCN2C(=O)CN3C=C(C)C=N3)C1 C=C(Cl)C(C)(C)C(=O)NCC(C)(C)CN(C)C(=O)[C@H1]1CCOC2(CCCCC2)C1 C=CC[C@]1(C(=O)NC[C@@H1](O)CCOC)CCN(C(=O)C2=NN=CC=C2C)C1 CC(C)(C)OC(=O)N1C[C@H1](F)[C@@](F)(C(=O)N[C@H1]2CNC3=CC=CC=C3C2)C1 CCC1=CN=C(C(=O)N[C@H1]2C=CC[C@H1](C(=O)N3CCC34CCSCC4)C2)N=C1 COCCN(CCNC(=O)CN(C)S(=O)(=O)C1=CC=CS1)C(=O)CS(=O)(=O)CC CNC(=O)C1(C(=O)N2CC[C@]3(C[C@H1](NC(=O)C(C4CC4)C5CC5)CO3)C2)CC1 C[C@H1](NC(=O)NC[C@]1(C)CCN(CC2=CC=CC=C2)C1)C3=CC=CC=C3O N#CC1=CC=C(C2=CC=CC=3N=C(C(=O)N4CCC(C(N)=O)CC4)[NH1]C2=3)C=C1 C/C=C/C[C@@H1](CC)C(=O)NC[C@@H1]1CN(C(=O)CCC2(C#N)CCC2)CCC1(F)F CC#CC1=CC=C(CNC[C@@H1](CC2=CC=CC=C2)C3CC3)C=C1 CCOC1=CC=C(C(=O)N2CCC[C@]23CCCN(C(=O)[C@]4(C)CCCS4)C3)C=N1 CN(CCCCNC(=O)[C@@]12CCC[C@@H1]1C2(F)F)C(=O)CCOC3=CC=CC(F)=C3 CN1CC(O)(CN(C)C(=O)[C@@H1](CCF)NC(=O)CN2CCOC2=O)C1 C#CCCCCCC(=O)N1CC(N(C)C(=O)[C@H1](OC)C2=CC=C(OC)C=C2)C1 COCCN(C)CC(=O)N1C[C@@H1]2CCN(C(=O)C[C@@H1](C)COC)C[C@H1]21 CC1=CC=C(C(=O)NC[C@H1]2CC3(CO2)CN(C(=O)CN4CC(=O)NC4=O)C3)N=C1 CCC1=C[NH1]N=C1C(=O)N2CCC(C3CCN(C(=O)COCCF)CC3)C2 CCN1CCC[C@H1]1C(=O)N2CC[C@H1]3[C@@H1](C2)[C@@H1]3C(=O)NC4CCC5(CC4)N=N5 COC1(CNC(=O)[C@@H1]2CCN(C(=O)C[C@H1]3C[C@H1]4C=C[C@H1]3C4)C25CC5)CCCC1 O=C(COC=CC(=O)C(F)F)N[C@@H1]1C[C@@H1]1CNC(=O)C2=CC=CC=3N=C(S)OC2=3 CN=C(NCCC1=CC(Cl)=CC=C1Cl)N[C@@H1]2C[C@H1]2C3CCCC3 CCN=C1[NH1]C(C(=O)NCCCN(C)C(=O)[C@H1]2SCCC=3SC=CC=32)=CS1 CCC1=CC=CC(C)=C1N2N=NN=C2[C@@H1](NCC(C)(C)OCCO)C3CC3 CCC(CC)C1CN(C(=O)[C@H1]2[C@@H1]3C[C@H1]2CN3C(=O)CC4C(C)(C)C4(C)C)C1 C=CCC(=O)NCCC1CN(C(=O)[C@H1]2C=C[C@H1]2C(=O)OC)C1 O=C(COC1CCCCC1)N[C@H1](C2=CC=C(F)C=C2)C3CCCC3 C[C@@H1]1CC[C@@H1](C(=O)N[C@@]2(C)CCCN(C(=O)CN3CCCCC3=O)C2)C1 CN1N=C(CNC(=O)[C@H1](O)C2CN(C(=O)C3=CC=C(O)N=N3)C2)OC1=O C[C@H1](NC(=O)C1CCCC1)C(=O)N[C@H1]2CCN(C(=O)C3=CN=CC(N)=C3)[C@@H1](C)C2 CN(CCCNC(=O)C1(CC2=CC=C(F)C=C2Br)CC1)C(=O)C3=CC(C)(C)C3 C=CCC(=O)N[C@H1]1COCC[C@H1]1C(=O)NC[C@H1]2C[C@H1](CN=[N+1]=[N-1])C2 CC1=C(C(=O)N[C@H1](C)CN(C)C(=O)CN(C)C(N)=O)OC2=C1C(=O)CCC2 CO[C@@H1](CO)CNC(=O)C=C(C)CNC(=O)[C@@H1](C)N1CCOC1=O CC(C)C1=CC(C(=O)N(C)CCCNC(=O)CN2C=C([C@H1](C)O)N=N2)=N[NH1]1 CC=1OC(C(C)C)=NC=1C(=O)NC[C@H1](C)CN(C)C(=O)C[C@@H1]2CCC3(CCC3)O2 CC/C(C)=C/C(=O)NC[C@](C)(CN1C=CC=N1)NC(=O)C2CC2 CSCC=1C=C(C(=O)N(CCNC(=O)[C@@H1](C)CSC)CCOC)SC=1C COCC1=CC=C(C(=O)N[C@@H1](C(=O)NC2=CC(C)=C(O)C=C2C)[C@@H1]3CCOC3)O1 CCC1(C#CC(=O)N[C@H1]2C[C@H1](CNC(=O)C3(C)CCC(C)CC3)C2)COC1 CC1=C(C(=O)N[C@@H1]2CC[C@H1]3CN(C(=O)CCCC#N)CC[C@@H1]3C2)C=NN1C(C)C C#CC1(O)CC(C(=O)N[C@@H1](CNC(=O)[C@H1](C)SC(F)(F)F)C2CCCCC2)C1 O=C(CCCCN1CCCC1)NCCCCC2CN(C(=O)[C@@H1](F)[C@@H1]3CCOC3)C2 C[C@@H1]1[C@@H1](NC(=O)C(F)(F)C=CC2=CC=CC=C2)CCCN1C(=O)C3=C[NH1]C(=N)O3 CCC1(NC(=O)CSC(F)F)CCN(C(=O)C2=CN=CC=C2C(F)F)CC1 C=CC(C)(C)C(=O)N1CCC[C@H1](N(CCO)C(=O)C2=C[C@H1]3C=C[C@@H1](C2)C3)C1 CC1=CC(C(=O)N2C[C@H1](NC(=O)/C(Cl)=C/Cl)[C@H1]3C[C@@H1]32)=C[NH1]C(C)=N1 NS(=O)(=O)CCC(=O)NC12CC(C=3N=N[NH1]N=3)(C1)C2 CNC(=O)C1=CN(CC(=O)NC[C@@]2(C)CC[C@H1](NC(=O)C3=CCOCC3)C2)N=N1 CN(C)S(=O)(=O)C1(COC(=O)[C@@]2(C)[C@H1]3CC4=CC=CC=C4[C@@H1]32)CCC1 CCN1N=C(C(=O)N2CC(C(=O)NN3N=NC4=C3CCCC4)(C5CC5)C2)C=C1O CC1=CC=C(CC(=O)N2CCN(C(=O)CC(C3CC3)C4CC4)[C@@H1]5C[C@@H1]52)C=C1C CC(C)CCN1CCC[C@@H1]1C(=O)NC2CC3(C2)C[C@H1]3NC(=O)C4=CC=CN=C4O CC[C@@H1](CN(C)C(=O)[C@H1]1OCC[C@H1]1C(C)C)NC(=O)C=2C=NN3C=2C(=O)NCC3 CCC1=CC(C(=O)N2C[C@@H1]3C[C@H1](NC(=O)CCCCC[C@H1](C)O)C[C@@H1](C3)C2)=N[NH1]1 CN1C=NC=C1CN2CC[C@@]3(CCC[C@@H1]3C(=O)NC4=CC(O)=C(Cl)C=C4F)C2 CC#CC[C@@H1](C)NC(=O)C[C@H1]1CCN(C(=O)[C@H1](O)CC(F)(F)F)C1 C[C@@H1]1CN(C(=O)C2(NC(N)=O)CC2)C[C@H1]1CCNC(=O)C[C@@H1]3CN4CCN3CC4 CC(C)(C(=O)N1CCC2(CN(C(=O)C3[C@H1]4CCCCCC[C@H1]34)C2)C1)C(F)(F)F CN(C)[C@@H1](CC[S@@](C)=O)C(=O)N1CCC[C@@](O)(CNC(=O)C2=CN=C(N)C=N2)C1 COC1=CC(OC)=C(CN2C[C@@H1](F)C[C@H1]2C(=O)N3C[C@H1]4CC[C@H1]3C4)C(OC)=C1 COC1(CC(=O)N2CCN(C(=O)[C@]3(N(C)C)CCCOC3)CC24CCC4)CCC1 CC[C@H1](CC(=O)NCC=1C=NN(C)C=1C(=O)N(C)[C@H1](CO)C2CC2)C3CC3 C[C@@H1](C(=O)N[C@H1]1CCN(S(=O)(=O)C2=CC=NC=C2)C1=O)N(C)CC(F)(F)F CC(C)OCC1(C(=O)NC2CC[P@]3(CCCC3)CC2)CCNCC1 COCCC(=O)N1CCOC[C@@H1](CNC(=O)C=2[NH1]C(C3CC3)=NC=2C)C1 CCN(C[C@H1]1CCCCN1C(=O)C[C@]2(O)CCCOC2)C(=O)[C@H1]3C[C@H1](SC)C3 CC=1C=C(F)SC=1C(=O)NC[C@H1]2[C@@H1]3C[C@H1]2CN3C(=O)C4=CC=C(C#N)C=N4 O=C(C1OCCO1)N2CC[C@@H1](C(=O)N3CCO[C@@H1]4CCCC[C@H1]43)O2 O=C(C(=O)N1CCCC[C@@H1]1CC=2N=N[NH1]N=2)N3CCN[C@@H1](CCO)C3 CN1C=C(C(=O)NCC2(C(=O)N3CC[C@]4(CO)CCC[C@H1]34)CCCC2)N(C)C1=O CCC=1SC=CC=1C(=O)N2C[C@@H1]3CCC[C@@]3(NC(=O)CCN4CCOCC4=O)C2 CSC[C@@H1](C)C(=O)NCCCCCNC(=O)CCC(=O)C1=CC=CS1 COC(=O)CC(=O)N1CC[C@@H1](C(=O)NCC2=CC(Cl)=C(Cl)C=N2)C1 CC1=COC(C=CC(=O)N2CCCC3(CCN(C(=O)C4CC(CF)C4)CC3)C2)=N1 CC[C@H1](C(=O)N1CC[C@H1]1C(=O)N[C@H1](CC)C(N)=O)C2=CC=CC=C2 CO[C@@]1(C(=O)NCC2=NC(CO)=N[NH1]2)CCN(C(=O)[C@@]34CC[C@@H1](C3)C4(C)C)C1 CC(=O)O[C@H1]1C[C@@H1]1C(=O)N[C@@H1]2CCCC[C@H1]2NC(=O)C3=CC(O)=NC(C)=N3 C=CC[C@@H1](CC)NC(=O)C1(CNC(=O)[C@@H1]2C=CCCC2)CC(C)(C)C1 C=CCC#CC(C)(C)CN[C@H1]1CCC[C@@H1](CCC(C)C)C1 C[C@H1]1CC[C@@H1](C(=O)NCC(C)(C)OCCNC(=O)C2=CN=NC3=CC=CC=C23)C1 O=C(OCC=C(Cl)Cl)C1=COCCOC=CC2=CC=CC=C21 CC1=NC=NC(O)=C1C(=O)N(C)C[C@@H1]2C[C@H1](F)CN2C(=O)C=CCO CC(C)CCC[C@H1](C)NC(=O)C1=CC(C2=CC=CC(CO)=N2)=NC=3[NH1]N=CC1=3 CC(C)(C)C1CC(CNC(=O)N[C@@H1]2CC=CCC2)C1 CCC1=NC=C(C(=O)N2CCC[C@@]3(CCCN3C(=O)[C@@H1](C)CC(F)F)C2)C=N1 CCC(F)(F)C(=O)NC[C@H1]1C[C@@H1](NC(=O)[C@H1]2CC3=CC=CN=C3C2)C1 COC1=CC=C(C)N=C1C(=O)N2[C@H1]3CC[C@@H1]2CN(C(=O)[C@@H1](C)CC(N)=O)C3 C[C@@H1](CNC(=O)C[C@H1]1COCC(C)(C)O1)N(C)C(=O)CCC2=NC=CS2 CN(C)CC1(C(=O)NC[C@]2(O)CCN(C(=O)COC=3C=CSN=3)C2)CCCCC1 CCC1=NN([C@@H1](C)C(=O)NCCN(C(=O)[C@@H1]2CCCC3=N[NH1]C=C32)C4CCCC4)C1 O=C(N[C@@H1](CCC1CC1)C(=O)N2CCC[C@@H1]2[C@H1](O)CO)[C@H1]3CC=CCO3 CCCCCN(CC)CCC(=O)N[C@H1](CCN(C)C(=O)CCCC(C)C)C(C)C CCC1=NC=C(C(=O)N2C[C@@H1]3CCN(C(=O)C4=CC=NN4C)C[C@@H1]32)[NH1]1 C=CCCOCCCCC(=O)N1CCC[C@](CC)(NC(=O)CC2=NN=C(C)S2)C1 CC[C@](C)(O)C(=O)NC[C@@H1](C)CN(C)C(=O)C1=NC=CN2N=CC=C12 CC1=NN=C([C@@H1](C)N2CC(O)(CNC(=O)[C@@]3(C)CNC(=O)C3)C2)O1 CCSCC(=O)N[C@H1](CNC(=O)C1=CC2=C(S1)CCOC2)C3=CC=CC(Cl)=C3 CC(=O)NCCC(=O)N[C@]12CCC[C@H1]1N(C(=O)[C@H1](C)C3=CC=CC(F)=C3)CCC2 CC1(C)CC(O)(C(=O)NCC2(F)CC(NC(=O)CC[C@H1]3CCCO3)C2)C1 CCOC(=O)CC[C@@H1](C)NC(=O)[C@@]1(C#N)CC2CCC1CC2 CC1(CN(C(=O)C2(C)CCC2)[C@@H1]3COC4(CCCC4)C3)CSC1 O=C(C=1C=C(C(F)F)[NH1]N=1)N2CC3(CC3)C[C@@H1]2CNC(=O)C4(C(=O)C5CC5)CC4 CC1=NC(Cl)=NC(NN=C(C2=CC=C(Br)C=C2)CCCCC)=N1 CCN(CCCNC(=O)C1=CC=NN1C(F)F)C(=O)[C@H1]2C[C@@H1](C(C)=O)C2(C)C CC(C)CC(=O)N1C[C@H1](NC(=O)C=2C=CC3=NN=NN3C=2)C[C@]14CCOC4 CCOC=CC(=O)N[C@H1]1C[C@H1]2CC[C@@H1]1N2C(=O)C=3C=C(CCOC)ON=3 O=C(CC1=N[NH1]C2=CC=CC=C12)N[C@H1](CNC(=O)C=C3CCSCC3)C4CCC4 C=CCCC(=O)N1CCN(C(=O)CC=2N=CN3C=2CCC3)C[C@H1]1CCC CCC=1C=C(CC(=O)N2CCOC[C@H1]2CNC(=O)C3=C(F)C=NC=C3Cl)ON=1 O=C(N[C@@H1]1CCO[C@@H1](C(F)(F)F)C1)C(=O)N2CCC(CCC(F)(F)F)CC2 FC1(F)C[C@]1CCCNC2=NC(N[C@H1]3CCN4C=CN=C4C3)=C5N=CSC5=N2 O=C(NCC[C@@H1]1CCCN1C(=O)C2CC3=CSC=C3C2)C4=NN[C@@H1](C(F)(F)F)C4 CCC[C@@H1](C)CC(=O)NC[C@@H1]1C[C@H1]1NC(=O)C2=CC3=C(O)C=CC=C3N2C CCC[C@@H1](NC(=O)C(C)=C1CC1)C2=CN(CCCCC(=O)OC)N=N2 C#CC1=CN=C(C(=O)N[C@@H1]2CN(C(=O)C=CBr)CCC23CCC3)C(C)=C1 N#C[C@@H1]1C[C@H1]1C(=O)N[C@@H1]2CCN(C(=O)[C@@H1](F)C(F)(F)C(F)(F)F)CC23CCC3 CCN1CC[C@H1]1C(=O)N[C@@H1](C)CC2CCN(C(=O)C3=CC=NC(C)=C3)CC2 C[C@@H1]1OC2(C)CC1(C(=O)N[C@@H1]3C[C@H1]4CN(C(=O)C=5N=C[NH1]C=5C(F)(F)F)C[C@H1]43)C2 CC1=CC(C(=O)NC23CC(C2)N(C(=O)CCCN=[N+1]=[N-1])C3)=CC(=O)N1C C[C@@H1](CCCNC(=O)[C@H1]1C[C@@H1]2CC[C@@H1]2C1)NC(=O)CCCC(F)(F)C(F)(F)F CCOC(=O)CCC(=O)N1CCN(C)[C@@H1](CNC(=O)C[C@@H1]2C=CCCC2)C1 [N-1]=[N+1]=NCCC(=O)N1CC[C@@H1]2CCC[C@@]21C(=O)NCC[C@H1]3C[C@H1](F)C3 C[C@H1]1CN(C(=O)CC2=CC=CC(F)=C2)[C@H1](C)CN1C(=O)CN3CCC(CO)CC3 CC1=C(C(=O)N(C)C[C@@]2(O)CCN(C(=O)C(C)(C)CS(C)(=O)=O)C2)CC1 CN(C)CC(C)(C)C(=O)N1C[C@@H1](CO)C2(CN(C(=O)C[C@H1]3CCCCO3)C2)C1 C[C@H1]1C[C@H1](CNC(=O)C23CCC(F)(CC2)C3)CN(C(=O)C=C4CCCCC4)C1 O=C(NCC1=CCN(C(=O)C=CC2=CC=CC=N2)CC1)C=3SN=CC=3Br CSC1=NC(N2CC(C)(NC(=O)C=CC3=CC=CC(CCO)=C3)C2)=NC=C1C CC(C)[C@@H1](C)CC(=O)N1CCCN(C(=O)C2CC(Cl)(Cl)C2)C[C@@H1]1C3=CC=CC=C3 COC(=O)C1=CC=NC=C1C#CCNC(=O)C=2C=C(C3CCOCC3)ON=2 C[C@@H1](C(=O)OC(C)(C)C)C(=O)N1CCCC[C@H1](NC(=O)CSCC(F)(F)F)C1 O=C(NC[C@H1]1CCN(C(=O)[C@H1]2CCCC[C@H1]2C3CC3)C1)C4=C(Cl)C=CN=C4F CS[C@H1](C)CCC(=O)N1CC[C@](C)(CNC(=O)C2(C3=CC=C(C)C(Cl)=C3)CC2)C1 O=C(NCC[C@@H1]1CC1(Br)Br)C2=NN(C3CCCC3)C=C2I CC1=NOC(C)=C1CCC(=O)N2CC[C@@H1](F)[C@@H1](NC(=O)CSCC(N)=O)C2 CCC(C)(C)NC(=O)[C@H1](C[C@H1]1CCC(C)(C)O1)N(C)CCOC2=CC=CC=C2Br C[C@H1](CN=C1N=C2C(C=NN2C)=C(NCC/C=C/Br)[NH1]1)CC3=CC=CS3 CN(C(=O)C1=CCC1)[C@@H1]2CC[C@H1]3CN(C(=O)C4=CN=C[NH1]C4=N)C[C@@H1]32 C=CCOC1=CC=CC=C1CNC(=O)C(=O)N2CC3=CC=CC(Cl)=C3C2 CN(C(=O)C1=NC=CC2=CC=NC=C12)[C@H1]3CCN(C(=O)CCSC(F)(F)F)C3 CCN1CCO[C@H1](C(=O)NC[C@@]2(C)CCN(C(=O)[C@H1]3CCC(=O)C3)C2)C1 NC(=O)C=C1C=C([N+1](=O)[O-1])OC(=NC(=O)NCC(=O)N)C1 O=CN(CC1=CC2=C(S1)CCCC2)C[C@H1]3OCC[C@H1]3F CC=1N=C[NH1]C=1CC(=O)N2C[C@@H1](CNC(=O)CSCC3=CC=C(Cl)S3)C[C@@H1]2C CC=1C=CSC=1CC(=O)N2CC[C@@](C)(C(=O)N[C@@H1]3CCC(=O)NC3(C)C)C2 CCOCC(=O)N[C@H1]1CC[C@@H1](C)N(C(=O)C2=CC=C3C(=C2)CCCCC3=O)C1 CCCCN(CCCC)C(=O)C1=CC(C2=CC=CN=C2SC)=CC=N1 N#CC1(C(=O)N2C[C@H1](F)[C@H1](NC(=O)C3=CN=C4C(=C3)CCS(=O)(=O)C4)C2)CC1 CC(NC(=O)C1CC12CC2)C(C)NC(=O)CCC3=CC(F)=CC=C3 C/C=C/C[C@H1](C)C(=O)N[C@@H1]1CCN(C(=O)CC=2SC(O)=NC=2O)CC1(C)C COC1=CC(Cl)=C(C(=O)N2C[C@@H1]3[C@H1](C(=O)N4CCC(F)(F)[C@@H1](C)C4)[C@@H1]3C2)C=N1 CC(=O)N[C@]1(CNC(=O)C2=CC(Cl)=CC(Cl)=C2[N+1](=O)[O-1])CCCC[C@H1]1C CC1=COC(C(C)C)=C1C(=O)N2CC([C@H1](C)NC(=O)C3=CC4=CC=CN=C4[NH1]3)C2 CC1=CC=C(C(=O)NCC2=CC=C(C(=O)N(C)[C@@H1](C)CC(N)=O)C=N2)C=N1 CC1=NC=CC=C1C(=O)N[C@@H1]2CN(C(=O)C3(CC(C)C)COC3)C[C@H1]2C(F)(F)F COC1(CC(=O)NCC2C(C3CN(C(=O)C4=CN=C5C=C(Cl)C=CN45)C3)C2)CC1 CCCC[C@@H1](F)C(=O)N1CCC[C@](C)(C(=O)N2CC(OCC(=O)NC)C2)C1 CC(C)CCCC(=O)N1CCC[C@H1](CNC(=O)CC2=C[NH1]C3=CC=CC(F)=C23)C1 CO[C@@H1](CO)C(=O)N[C@@H1]1CC[C@H1](CNC(=O)C2(CF)CC(F)(F)C2)C1 CC(=O)NCCCC(=O)N(CCO)[C@H1]1CCN(C(=O)CCN2C=NN=N2)C1 CC(C)[C@H1](CCN(C)C(=O)C1(C)CCCC1)NC(=O)[C@@H1]2C[C@@H1]2C3CCCC3 O=C(NC[C@@H1]1CC2(CCC2)CN1C(=O)C3(O)CC3)C4=CC=C(C(F)(F)F)C(Cl)=C4 COC(=O)N[C@@H1](C)C(=O)N1CCC[C@@H1](CNC(=O)C=2[NH1]C(C)=NC=2C)CC1 O=C(N[C@@H1]1[C@H1]2CCN(C(=O)C=CC3=CN=CS3)C[C@H1]21)C4=CSC(Cl)=N4 C[C@H1]1CC[C@H1](C(=O)NC[C@H1]2CCC[C@@H1](NC(=O)CN3CCC(C)(C)C3)C2)O1 CC=1[NH1]N=C(C(F)(F)F)C=1C(=O)N2C[C@@H1](NC(=O)[C@@H1](F)CC3CC3)C4(CC4)C2 CC1=C(C(=O)N2CCN(C(=O)C=3C=CN(C)C=3)C[C@@H1](O)C2)C=CN1CC4CC4 O=C(N[C@H1]1CN(C(=O)C=2C=NSN=2)CC1(F)F)C3=CC=C(O)C=C3F O=C(C1=CON=C1C2CCC2)N3CC[C@@H1]4CCN(C(=O)[C@H1]5C[C@@H1]5Cl)[C@H1]4C3 CC=1[NH1]N=C(C(=O)N2CC[C@H1](C3=CC=CC(C(=O)O)=C3)C2)C=1N O=C(CN1CCC2=NC(C3CC3)=NN2C1)C4=CC=C(Cl)C=C4 O=C(C#CCNC(=O)C1=NC=NC=C1O)NC[C@]2(O)CCCOC2 CCN(CCCNC(=O)C(C)(C)C(C)C)C(=O)[C@@H1]1CSC(C2=CC=C(C)O2)=N1 CC(C)(C(=O)NC[C@@]1(F)COCCN(C(=O)[C@H1]2CCNC2=O)C1)S(=O)(=O)C3CC3 O=S(=O)(NC[C@H1]1C[C@@H1]1Cl)C2=CC=C(NCC3CCCCCCC3)C=C2Cl CCC1=N[NH1]C=C1C(=O)N2CC(C[C@@H1](C)NC(=O)C3=CSC=C3SC)C2 CC[C@H1](CNC(=O)C[C@H1]1C=CS(=O)(=O)C1)NC(=O)CNC(=O)C=2C=COC=2 C#CCC[C@H1]1CCCN(C(=O)[C@H1]2CN(C(=O)C3=CC(C)=C(C)[NH1]3)CC2(C)C)C1 COC=C1C=C(F)C(C(=O)NC2=CC=CC=3N=C(C(C)C)[NH1]C2=3)=NC1F COC=1C=C(C(=O)NC[C@H1]2C[C@H1]2CC(=O)NC[C@@]3(C4CC4)CCCO3)[NH1]N=1 CCC1=CN=CC=C1C(=O)N2C[C@@H1](C)[C@@H1](NC(=O)CC(F)(F)C(F)F)C2 COC(=O)[C@@H1]1C[C@H1](C)CN(C(=O)[C@@H1]2CC3(CC3)CN2C(=O)C4=CC=CC=C4F)C1 O=C(CNC(=O)C1=C[NH1]C2=CC=CC=C12)NC3CC(NC(=O)[C@H1](O)CC4CC4)C3 CO[C@@H1]1CCCC[C@@H1]1C(=O)NC[C@](C)(NC(=O)[C@@H1]2C[C@]2(C)Br)C3CC3 COC(COCCN1CC[C@H1](CC(=O)N[C@H1](C)C2=CC=C(C)C(N)=C2)C1)OC CCN1N=NC2=C1CC[C@@H1](C(=O)NC3CN(C(=O)[C@@H1]4CCCN4C(C)C)C3)C2 CCC[C@H1](CC)CCC(=O)N1C[C@H1]2CC[C@@](CNC(=O)C3[C@H1](C)[C@H1]3C)(C2)C1 COC(=O)CCCCC(=O)N1CC(=O)NC[C@@H1]1C(=O)NC[C@](C)(O)CSC COC1=CSC(C(=O)N[C@H1](CNC(=O)C2=CC=NC=C2C)CC(C)C)=C1 C[C@@H1]1[C@H1](NC(=O)[C@H1]2CCCC23CCC3)CCCN1C(=O)C4=CC=CC=5C=C[NH1]C4=5 C[C@]1(F)CN(C(=O)C2=CSC=3N=NSC2=3)CCN(C(=O)C=CS(C)(=O)=O)C1 CNC1=NC(C)=CC=C1C(=O)N[C@@H1]2C[C@H1](C)N(C(=O)/C=C/[C@H1]3CCCO3)C2 CCC1=NC(C(=O)N[C@@H1](CNC(=O)[C@H1]2C[C@@H1]3C[C@@H1]3C2)CC)=C(Br)S1 CC1CC(CCC(=O)N2C[C@@H1]3C[C@]3(CNC(=O)C4=CN=C5C=CC=CC5=N4)C2)C1 C[C@@H1]1CC[C@H1](CNC(=O)[C@@H1]2CCCCCCN2C(=O)C3[C@H1]4CC(=O)C[C@H1]34)C1 C[C@@H1]1CN(C(=O)[C@@H1]2C(F)(F)C23CC3)C[C@H1]1CCNC(=O)C4=CC=C(Cl)C=C4 CN1N=C(C(=O)NCC2(F)CN(C(=O)CC#N)C2)C3=C1CCS(=O)(=O)C3 C=C(C)CCCC(=O)N[C@@H1]1[C@H1]2C[C@@H1]3CN(C(=O)[C@@H1]4C[C@@H1]5CCC[C@@H1]54)[C@H1]1[C@H1]3C2 COC1=CC=C(C(=O)N[C@@H1]2COCC[C@@H1]2NC(=O)CC3=CC(C)=NS3)C=C1 CC(C)[C@@H1]1CCN(N2CC[C@H1](CC3=CC=CC=C3F)C2)C1 CCCC(=O)NCC1(F)CCN(C(=O)C=2C(C3=CC=CC=C3OC)=NOC=2)CC1 C[C@@]1(CCNC(=O)[C@@H1]2CC(=O)CC23CCC3)CCN(C(=O)C=C(Cl)Cl)C1 C[C@@H1](C(=O)N1CCN(C(=O)C2=CC(Cl)=CC=3N=C(Cl)SC2=3)CC1)N4C=CC=N4 CC[C@H1](CC(=O)N[C@@H1]1C[C@H1](C(=O)N2CCC[C@H1]2CNC(C)=O)C13CCC3)C(C)C C#CC1=CC=CC(CC(=O)N[C@@H1]2CC[C@]3(CCN(C(=O)CN4CC=CC4)C3)C2)=C1 CNCCCC(=O)NCC(O)CNC(=O)C[C@H1]1COC2=CC(O)=CC=C21 CCOC1=CC(N2[C@H1]3CC[C@H1]2CN(C(=O)[C@@H1]4C[C@H1]5CCC[C@H1]54)C3)=NC=N1 C[C@@H1](CC(F)F)NC(=O)N=S1(=O)CCOCC1 C=CCC[C@@H1](NC(=O)CCCOCC)C(=O)NN1C=CC=N1 CN1C=CC=C1CC(=O)N2CCOCC[C@H1]2C(=O)NC[C@H1]3CCC4(CCC4)O3 CCC(CC)N(C)CCC(=O)N[C@H1](C)[C@H1](NC(=O)CCCCC(F)(F)F)C(C)C C[C@@H1](CC1CN(C(=O)[C@H1](C)OC2=CC=C(F)C=C2)C1)NC(=O)C3(CC(F)F)CC3 C[C@@H1]1CN(C(=O)CN2C=NC=CC2=O)C[C@H1]1CNC(=O)C(=O)C3=CC=C(Cl)C=C3 O=C(CN1CCN(C(=O)[C@@H1](F)N2C=CN=C2)CC1)N3CCC[C@@](O)(CO)C3 CC(CCN1CCCC1)NC(=O)[C@@H1]2[C@H1]3CN(C(=O)CCN=[N+1]=[N-1])C[C@H1]32 CC(C)[C@@H1](O)C(=O)NC[C@@H1]1CN(C(=O)C=2C=NN3C=NN=C3C=2)CCCO1 CN(C)C(=O)C=CC(=O)NC[C@@]12C[C@@H1](CO1)N(C(=O)CCC3=CC=C(O)N=C3)C2 N#CC1=CC=C(Br)C(CN2CCN(C(=O)C3=CC4=CC=CC=C4O3)C[C@@H1](O)C2)=C1 CC(C)S[C@H1](C)C(=O)N1CC[C@H1](C2(NC(=O)C3=NC=NC=4C=C[NH1]C3=4)CC2)C1 COC1=NC(C)=NC=C1C(=O)N2C[C@H1](C)[C@@H1](NC(=O)/C(C)=C/C(C)(C)C)C2 O=C(NCC[C@H1]1CCN(C(=O)C2(CC3CC3)CC2)C1)C4=CC(C(F)(F)F)=NC=N4 CN(C)CCSCC(=O)NCCO[C@H1]1CCN(C(=O)C2C[C@H1]3CC[C@H1](C2)C3)C1 CC1=CC=C(C(=O)N[C@H1]2CCC[C@@H1](N(C)C(=O)[C@H1]3C[C@H1](F)C3)C2)C=C1N CC[C@](C)(O)C(=O)NCCC1(O)CN(C(=O)C(=C(C)C)C2=CC=CC=C2)C1 CC(C)C1=NC(C(=O)N2CCO[C@H1](C3=CN(C(C)(C)C(=O)CO)N=N3)C2)=CO1 COC1(C#N)CC(C(=O)N[C@H1]2C[C@H1](O)[C@@H1](NC(=O)C3=NC=C(F)C=N3)C2)C1 CCC[C@H1](NC(=O)CCOCCN(C)C(=O)CC1(CC)CCC1)C(C)(C)C C#CCCCC(=O)N[C@@H1](C)CNC(=O)C1=CC2=C(C=C1Cl)NC(=O)CO2 CSC=CC(=O)N1CCC[C@H1](N(CC2CC2)C(=O)CN3CC=CC3)C1 CC1(C)CCN(C(=O)C2=CN(C3CCC3)N=N2)C[C@@H1]1CNC(=O)C4=CCCOC4 CC(C)C1=NC=C(C(=O)N[C@@H1]2COCC[C@@H1]2NC(=O)[C@@H1]3C[C@H1]3C4CCC4)S1 C[C@@]1(CC(=O)N[C@@H1](C(=O)N[C@H1]2[C@H1]3CC[C@H1]4[C@@H1](C3)C[C@H1]42)C5C[C@@H1]6C[C@H1]6C5)CCOC1 COC1=CC=CC(C)=C1C(=O)N2CCN(CC(=O)NOCC(F)F)C(=O)C2 C#CCCC(=O)N1CC[C@@H1](CC(=O)N[C@H1](C)C(=O)C2=CC=C(Br)S2)C1 COC1=CC=C2C(=C1)[C@@H1](C(=O)OCC3=CC=C(I)C=C3Br)CCC2 CO[C@@H1]1C=CCN(C(=O)[C@@]23C[C@@H1]2CN(C(=O)CN4CCC[C@@H1]4C)C3)C1 CC=C(C)C(=O)N[C@H1](C)CC1CCN(C(=O)C#CC(C)C)CC1 C[C@H1](CCNC(=O)C1CCCC1)N(C)C(=O)CSCC2=CC=C(Cl)C=C2 C=CCCOCC(=O)N[C@@H1](CCN(C)C)C(=O)N1CC[C@H1]2[C@H1](COC)[C@H1]2C1 CC[C@@H1]1CCC[C@H1](NC[C@@]23CC[C@@](C(=O)OC)(CC2)C3)C1 CC(C)=CC(=O)NC(C)(C)[C@H1]1CCCN1C2=NC=NC=3C(C)=CSC2=3 CC1=CC=C(C(=O)NC2=CC(F)=CC([N+1](=O)[O-1])=C2)C=N1 CN1C(S)=NN=C1C(=O)N2CC[C@H1](CCC(=O)NCC3=CC=CC(CO)=C3)C2 CC1=CSC(CC(=O)N[C@H1]2CCOC23CCN(C(=O)CN4C=NN=C4)CC3)=C1 COC1=CC=C(CC(=O)N(C)CC[C@@H1](C)NC(=O)CN2CCC[C@@H1]2C)C=C1OC C[C@@H1](C(=O)N(C)[C@H1](CNC(=O)C[C@H1]1OCCCC1(C)C)C2CC2)N3CCSCC3 CC(C)[C@@H1](C#N)C(=O)N[C@@H1]1CC[C@H1](NC(=O)CCNC(=O)C=2C=COC=2)C1 CCN1C=C(C(=O)N[C@H1]2C[C@](F)(CNC(=O)CC3=CC=CN=C3O)C2)C=N1 CC(C)(C)OC(=O)N1C[C@@H1](NC(=O)C2=CC=CC=3[NH1]C=C(C#N)C2=3)CCO1 CC[C@H1](NC(N)=O)C(=O)NC[C@H1](C)N(C)C(=O)C1=CC=C(C2=CC=CN=C2)S1 COCO[C@@H1](C)C(=O)N1CCN(C(=O)C2=NN=C(O)C3=CC=CC=C23)C[C@@H1]1C O=C(N[C@@H1]1C[C@H1]2CN(C3=NC(Cl)=NC=C3[N+1](=O)[O-1])C[C@@H1]21)CC4=CC=C(F)C=C4 C=C[C@H1](CC1=CC=CC=C1)OC(=O)[C@@H1]2CC(=O)CN(C(=O)OC(C)(C)C)C2 CCC1=NC=C(C(=O)N(C)[C@@H1]2CCN(C(=O)COC(F)(F)F)CC23CC3)[NH1]1 O=C(N[C@@H1](CCO)C1CCC1)NC[C@]2(C(=O)O)C[C@H1]3CC[C@H1]2C3 CCC=1N=NSC=1C(=O)N2CCC[C@H1]2CN(C)C(=O)CNC(=O)[C@H1](C)CC C#CC1=C[NH1]N=C1C(=O)N2C[C@H1]3CC[C@]3(CCNC(=O)C4=CC=NC=C4)C2 CC1(C)CC[C@@H1](C(=O)NCCCN2CCN(C(=O)CCC3=CC=CC=N3)CC2)O1 CC1=CC(C(=O)NC[C@H1]2CCCC[C@H1]2C(=O)N3C[C@@H1]4[C@H1]5CC[C@H1](C5)[C@@H1]43)=NO1 CC(C)C[C@@H1](C)C[C@H1](C)OC(=O)C1=CC(Cl)=CN=C1O CC1=CC=C(NC(=O)[C@@H1]2C[C@@H1]2C(=O)N(CC3=CC=CN=C3)C(C)C)C(CO)=N1 COC(=O)[C@@H1]1C[C@@H1]1C(=O)NC2=NC=C(Cl)N=C2C(=O)N[C@@H1](C)C3=CC=CC(F)=C3 CN(CCCN(C)C(=O)[C@H1]1CCCC(C)(C)CC1)C(=O)C2=CC=C(CCF)C=C2 CC[C@@H1](C(=O)N[C@H1]1C[C@@H1](CCC(=O)N[C@@H1](C)C(=O)N(C)C)C1)N(CC)CC CN1CC=C(C(=O)N[C@@H1]2[C@H1]3C[C@H1](NC(=O)[C@H1]4CCC(=O)NC4)C[C@H1]32)C1 CN(CC1CCN(C(=O)C(C)(C)N(C)C)C1)C(=O)/C=C/C2=CSC3=CC=CC=C23 CN(CC1=CC=CN=N1)C(=O)[C@H1]2CC(=O)CN2C(=O)C3(CF)CC3 C=C(Cl)CCC(=O)N1CCC2=C(CNC(=O)[C@@H1]3CC4=NN=CN4C3)C=CC=C2C1 CCN1C=C(NC(=O)[C@H1]2CN(C(=O)[C@H1]3COC[C@H1]3C(N)=O)CCN2C)C(C)=N1 C=CCN(CC(=C)Br)C(=O)C1=CC(F)=N[NH1]1 CS[C@H1](C(=O)NC[C@@](C)(O)CNC(=O)C1=C(F)C=C(C#N)C=C1F)C(C)(C)C CCN1C=C([C@@H1](C)NC2=CC(C)=C(S(=O)(=O)N(C)[C@@H1]3COC(C)(C)C3)C=N2)C=N1 CCOC(=O)CC(=O)N1CC(C[C@H1](F)C(=O)N2CC3(C2)CC(C)(C)C3)C1 CC(=O)N[C@@](C)(C(=O)N1CC[C@@H1](CO)[C@H1](NC(=O)[C@H1]2C[C@H1]3[C@@H1](C2)C3(F)F)C1)C4CC4 CN(CC1=CN(C)N=C1C(F)(F)F)[C@@H1]2CCN(C(=O)CC3=C[NH1]C4=NC=CC=C34)C2 CO[C@@H1]1C[C@H1]1C(=O)N2CC[C@@]3(CCN(C(=O)C4=CSC(Br)=C4)C3)C2 COC1=NC=C(Br)C(=NCCNC(=O)[C@H1](C)[C@@H1]2CCCO2)[NH1]1 COC1=CC=NC(C(=O)N[C@H1]2CN(C(=O)[C@H1]3CCC[C@@H1](N(C)C)C3)C(C)(C)C2)=C1 C[C@]1(C(=O)N=C2C=CN(C3CCC3)[NH1]2)C[C@@H1](O)CN1C(=O)C4=NC=CC=C4O C[C@H1](CCNC(=O)[C@H1]1C[C@@H1](C#N)C1)NC(=O)[C@]2(C)CCCNS2(=O)=O CCCC[C@H1](O)CC(=O)N1C[C@@H1](C)C[C@H1](C(=O)NCC=2C=COC=2C)C1 COCCOCC=CC(=O)NC[C@H1]1[C@H1](OC)[C@H1](OC)CN1C(=O)CS(=O)(=O)CC CNC(CCN=C(NC1CC1)NC2CCN(CC(F)(F)F)CC2)=NC3=CC=CC=C3 CC(C)[C@@H1](F)C(=O)N1CC(O)(CCNC(=O)CC2(N(C)C)CCCC2)C1 C[C@H1]1C[C@H1](NC(=O)C2=CC(F)=CC(F)=C2)CN(C(=O)C3=CN=CN3C(F)(F)F)C1 CS[C@H1](C)C(=O)N1CCC2(CCC[C@H1]2CNC(=O)[C@@H1]3CCC4=N[NH1]C=C4C3)CC1 CCCOCC(=O)N(C)[C@H1]1CN(C(=O)C=2C=CN(C)C=2CC)CC[C@H1]1C C[C@H1](C(=O)N1CC(NC(=O)C2=CC=C(Cl)C=N2)C1)C(C)(C)C CCC1=CC=C(C(=O)N[C@@H1](CC)CN(CC)C(=O)C=2C=C(S(N)(=O)=O)OC=2C)O1 CC1=CC(C(=O)NC[C@@H1]C[C@H1](CNC(=O)C2=CN=C3C=CC=NC3=C2)CO)=CS1 C[Si]1(C)CCN(C(=O)C[C@H1]2[C@H1]3CCC[C@H1]3N2C(=O)[C@H1](F)N4C=CN=C4)C1 C[C@H1]([C@H1]1CCCOC1)[C@H1](C(=O)NC2CCC2)N3CCC[C@H1](C4=NC(=N)N(C)[NH1]4)C3 [N-1]=[N+1]=NC[C@@H1]1CCN1C(=O)[C@H1]2COCCN(C(=O)C3=CC=NC(O)=C3F)C2 CN(CC1=CC=C(OC(F)(F)F)C=C1)[S@@](=O)CC2=C(F)C=CC=C2F C[C@@]1(C(=O)N[C@@H1]2CC[C@](F)(CNC(=O)C=3OC=NC=3C(F)(F)F)C2)CCNC1=O CCCN(C(=O)C1=CN=C(O)C(F)=C1)[C@H1](C)C(=O)NC[C@@H1](CO)C(F)(F)F CP(C)(=O)C=1C=NN(CC(=O)NC[C@@H1]2C[C@@H1]2CNC(=O)C3=CN=CC(N)=N3)C=1 CCSC(=S)S[C@H1](C)C(=O)N1C[C@@H1]2C[C@@H1]3C[C@H1]1[C@@H1]2C3 O=C(CO)NC[C@@H1]1C[C@H1]2CN(C(=O)CCC3=C[NH1]C4=CC=CC=C34)C[C@@H1]12 C=CCCCCCC(=O)NC[C@]1(C)CCCN1C(=O)CSC=2N=C[NH1]N=2 C[C@@H1]1[C@H1](C(=O)NCC23CC(CN2C(=O)[C@@H1]4CCCC[C@@H1]4O)C3)[C@@H1]1C CC1=NC(C2CC2)=CC(N3CC[C@@](O)(C4=CC=C(F)C=C4)C3)=N1 CC1=CSC(CC(=O)NC[C@H1]2CN(C(=O)C3=CC=NC=4N=CSC3=4)C(C)(C)C2)=C1 C=CCOC1=CC=C(NC(=O)C(F)(F)C=2C=NN(C)C=2)C(C)=C1 COC1=CC=C(C(=O)N(C)CC2CN(C(=O)[C@@H1]3CCC[C@H1]4[C@H1]3C4(F)F)C2)C=C1Cl C[C@@]1(CNC(=O)C=2[NH1][NH1]C(=N)C=2Br)CCCN1C(=O)C3=CCSC3 CCC=1OC(C)=CC=1C(=O)N(C)C[C@H1](O)CN(C)C(=O)[C@H1]2C[C@H1](O)CN2C(C)=O CCN1N=CC=C1C(=O)N2CC[C@@H1]3[C@@H1](CCN3CC4=CC=NC(Cl)=C4)C2 CCCC(C)=CC(=O)NCC1CN(C(=O)C2=CC(OC)=NO2)C1 O=C(CCN1CCCC1)N[C@@H1]2CCC[C@H1]2C(=O)NCC3=CC=NC(OC(F)F)=C3 C[C@@H1](OC1CCCC1)C(=O)N[C@@H1]2COC3(C2)CN(C(=O)C4=CC=CC(C#N)=C4)C3 CCSCCCNC(=O)[C@@H1](C=1SC=C(OC)C=1OC)N2CCC(CO)CC2 O=C(CC[C@H1]1CC1(F)F)NC[C@@H1](O)C(=O)NCC2CCCCC2 CN1C=NC2=C(NC(=O)[C@@]3(C)CCN(C(=O)[C@H1]4C[C@@H1]4C5CC5)C3)N=CN=C21 CCNC(=O)CCC(=O)NC[C@@H1]1CN(C(=O)C=2OC(C)=NC=2C)[C@@H1]3C[C@H1]13 CC=1N=CN(C)C=1C(=O)NC[C@@H1]2CN(C(=O)[C@H1](C)CC(C)C)CC[C@@H1]2C NC(=O)C=CN=CCC(=O)N1CCC[C@@H1]2CN(C(=O)CS(N)(=O)=O)CC[C@H1]21 CC(C)CN1CCC[C@H1](C(=O)NC[C@H1]2[C@@H1]3CC4[C@@H1](CN3C(=O)CO)[C@H1]4C2)C1 CC=1C=C(N)N(C2=CC=C(C(=O)N3C[C@H1]4C[C@@H1]5C[C@H1]3[C@@H1]4C5)C=C2F)N=1 CC(C)[C@H1](CNC(=O)C1=CC=CC(F)=C1)NC(=O)C=2[NH1]C=C3C=2CCS3(=O)=O CC(C)[C@H1](C(=O)NC12CC(NC(=O)C3=CC=C4C=CN=CC4=C3)(C1)C2)N(C)C C[C@H1](NC(=O)[C@@H1]1CSCC(=O)N1)C2=NC(C(=O)N3CC[C@]34CCCOCC4)=CO2 CONC(=O)CNC(=O)[C@@H1](O)C1CN(C(=O)CNC(=O)C(C)(C)C)C1 CCN(CCNC(=O)C(F)(F)CO)C(=O)C1=CC=C(C2=NN=CN2C3CC3)C=C1 O=C(C[S@](=O)C1=CC=C(Cl)C=C1)NCC2(NC(=O)[C@@H1]3CCS3(=O)=O)CCC2 CC1(C)CC[C@@H1](CNC(=O)CNC(=O)C2CCOCC2)N(C(=O)[C@@H1]3CC3(F)F)C1 CCC(C)(C)OCC(=O)N1C[C@H1]2C[C@@H1](C1)[C@H1](NC(=O)CC3=CN=CC=C3Cl)C2 C[C@H1]1CCCN1CC(=O)N[C@H1]2C[C@@H1](NC(=O)C3([C@@H1]4CCCO4)CC3)C2 COCC1(CNC(=O)[C@H1](C)CN(C)C(=O)C=2C=CSC=2OC)CCCC1 CC1=NC(O)=NC(C)=C1C(=O)N[C@H1]2C[C@H1](CNC(=O)C=3N=C(Cl)OC=3C)C2 COC(C)(C)[C@H1]1CCCN1C(=O)C=2SC=CC=2CNC(=O)[C@H1]3CCN3C(C)(C)C COC[C@H1](O)C(=O)N1CCC2(CC1)C[C@H1]2CNC(=O)C3=NN(C)C(=O)C=C3C CC=1OC=CC=1C(=O)N[C@H1]2C[C@@H1](C(=O)N[C@H1]3C[C@H1]4C=C[C@H1]3CC4)C25CCC5 CC=1C=CN(CCC(=O)N[C@H1]2CN(C(=O)COC3=CC=CC(F)=C3F)C[C@@H1]2C)N=1 CC1=C(C(=O)NCC(C)(C)CN(C)C(=O)C2=CC=C(C(F)(F)F)C=C2)C=CN1C O=C(N[C@H1]1C[C@@H1](NC(=O)C2(C3CCC3)CC2)C1)C4=COC(CC5CC5)=N4 C[C@H1](CC(N)=O)C(=O)N(C)CCOCCN(C)C(=O)CC1=CC=C(C#N)C=C1F O=C(C1CC(F)(F)C1)N2CCC(O)(CN=C3C=C(C4CC4)N=C(Cl)[NH1]3)CC2 C[C@H1](OC(C)(C)C)C(=O)N1CC[C@](C)(C(=O)N2CC[C@H1](O)[C@H1](O)C2)C1 CC(C)[C@H1](C(=O)NC[C@@H1](F)CO)[C@@H1](C)NC(=O)CC1=CC=CN=C1O C[C@@H1]1CN(C(=O)C2=CN(CC(N)=O)N=N2)CCN1C(=O)C=3C=C(CCO)ON=3 COC(=O)[C@@]12CCCC[C@]1(C(=O)N[C@H1]3C[C@H1](CNC(=O)[C@H1]4CCSC4)C3)CC2 CN(C)C1=CC=C(N2C=C([C@@]3(C)CCN(C(=O)CC[C@@H1]4CCOC4)C3)N=N2)C=C1 COC(=O)C1=CC(S(=O)(=O)N[C@H1](C)C2=C(F)C=CC=C2Cl)=C(F)C=C1Br COC1(CNC(=O)C2=CN=C(C)N=C2C)CCN(C(=O)[C@@]3(F)C[C@@H1]3C)CC1 CC1(C(=O)N(C)CCC2CC2)CN(C(=O)CC3=CC=CN=C3)C1 C#CC[C@H1](CC(=O)NC1CC(=C2CC2)C1)NC(=O)C3=CCCCC3 CNC(=O)C1=CC=CC(C(=O)N2CC=C[C@@H1]2CNC(=O)[C@]3(C)CC=C(C)CC3)=N1 COC1=NC(C(C)C)=CC=C1C2=CSC(C(=O)N=C3C=C([C@H1]4CCOC4)[NH1][NH1]3)=C2 CCCC[C@H1](O)C(=O)NC1(C)CCN(C(=O)CC2=NN(C)C=C2Cl)CC1 CN(CCN(C)C1CC1)C(=O)C[C@H1]2CC(C)(C)CN2C(=O)[C@@H1]3COCC3(C)C CNC(=O)CC(=O)N1CCOC2(CCN(C(=O)[C@@H1]3[C@H1]4CCC[C@H1]43)CC2)C1 N#CC=1SC(N2C[C@H1]3[C@@H1]4CC[C@@H1](CN4C(=O)C5=CC=[N+1]([O-1])C=C5)[C@H1]3C2=O)=NC=1Cl CC1=CC=CC([S@](C)(=O)=NC(=O)[C@H1]2CC=C[C@H1](N3C=C(CN(C)C)N=N3)C2)=C1 CNC(=O)CCCCC(=O)N[C@@H1](C)CCNC(=O)[C@H1](CCSC)NC(N)=O CC1=NC(C(=O)N2C[C@@H1](F)C[C@H1]2CNC(=O)CC3=NN=C(C)S3)=CN1C(F)F CC(C)N(CCCO)C(=O)C1=C[C@]2(CCN(C(=O)C=3C=C[NH1]C=3)C2)C1 O=C(N[C@@H1]1CN(C(=O)[C@@H1]2C=CCCC2)CCC13CCC3)C=CC4[S@](=O)CCO4 CC=C[C@H1](O)C(=O)N[C@H1](CCC)CC(=O)NCC1=CC(C)=NO1 COC=1C=CSC=1C(=O)N2CCC([C@@H1](F)CNC(=O)[C@@H1]3C[C@@H1]4CC[C@H1]3O4)CC2 CC(C)(C)CCC(=O)N1C[C@H1](O)[C@H1](NC(=O)C2=CC=C(C(F)F)C=C2)C1 CC1=C(CNC(C)(C)C2=CN=CN2C)N(C)C3=CC=CC=C13 O=C(/C=C/C=1C=CSC=1)NC2CN(C3=NC=NC4=CC=C(Br)C=C34)C2 C[C@@H1](C1CCC1)N(C)C(=O)N[C@@H1]2CCC[C@H1](O)CC2 NC(=O)C(=O)N1CCN(C=2C=CC3=NN=NN3N=2)C[C@@H1]1CC=O CC(=O)N(C)[C@@H1](C)C(=O)N[C@H1]1C[C@@H1](CCNC(=O)C2[C@H1](C)[C@H1]2C)C1 CCOC1=NC=C(C(=O)N2CCC[C@@H1](CN(C)C(=O)CC3=CSC(S)=N3)C2)S1 CC1=CC(C(=O)N[C@]2(CO)CCN(C(=O)[C@H1](O)C(C)(C)C)C2)=CN=C1O CN(C)[C@H1]1CCC[C@H1]1CNC(=O)C2(CNC(=O)[C@H1]3CCOC3)CC=CC2 O=C1CC[C@@H1](CC(=O)N2CC[C@@H1](NC(=O)C34CC5C[C@H1]3[C@H1]4C5)[C@H1](CO)C2)C(=O)N1 CC1=CC=CC(C(=O)N2CC[C@H1]3[C@@H1]2CCCN3C(=O)C4=NC=NC=C4F)=C1C CCCCSCC(=O)NC[C@H1]1CCCCN(C(=O)C=CC2=CC=CC(O)=C2)CC1 C[C@@H1]1CCN(C(=O)[C@]23CCC[C@H1]2C3(F)F)C[C@H1]1NC(=O)CC4=CC=C(F)C(F)=C4 C[C@H1](NC(=O)/C=C/C1=CC=CC=C1)C(C)(C)NC(=O)CCC2=CC=CC(Cl)=C2 CCC=C(F)C(=O)NC[C@H1]1CC2(CCN(C(=O)C3=CC(Cl)=C(Cl)[NH1]3)CC2)CO1 CN(CC1(CNC(=O)C[C@@H1]2CC[C@H1]3C[C@H1]23)CC1)C(=O)/C=C/C(C)(C)C COC[C@@]1(C(=O)NCC2=CSC=C2C)C=CCN1C(=O)C3=NOC=C3Cl CC(=CC(=O)NC[C@]1(C)CC[C@H1](NC(=O)C2(N(C)C)CCCCC2)C1)C(C)(C)C CC1=NSC(CNC(=O)[C@@H1]2CSCCN2C(=O)CCC3CC3)=N1 C#CC[C@H1](O)C(=O)NC[C@]1(COC)CCCN1C(=O)C2=CC(C)=CC(O)=C2 COC(=O)C1=CC=C(C(=O)N(C)[C@@H1]2CCN(C(=O)C=3OC=C(C)C=3C)C2)C=C1Cl CC1=CC(F)=CC=C1CC(=O)N[C@H1]2CN(C(=O)[C@H1]3CC=CCO3)C[C@@H1]2C C#CC1=C[NH1]N=C1C(=O)N2CC(C)(C(=O)N3CC[C@@](O)(C(N)=O)C3)C2 CCC[C@H1](OC)C(=O)N[C@@H1](C)[C@@H1](CO)NC(=O)COC1=CC=C(C(C)(C)C)C=C1 CC1=CC(=NC(=O)CN(C)N2CC[C@H1](OC3=CC=C(C#N)C=N3)C2)[NH1]O1 CC1=CC(C(=O)N2CCC[C@H1]2C3=CC=NN3C)=CC=C1N4CCCS4(=O)=O O=C(N1CC2CC1(CNC(=O)[C@]34CCCC[C@@H1]3C4)C2)C5(CF)COC5 CC1=NC=CC=C1CC(=O)NC[C@@]23CC[C@@H1]2CCN3C(=O)C=4SN=C(O)C=4Cl CC(C)=C[C@H1]1[C@@H1](C(=O)N2CC[C@]3(CCN(C(=O)CC4(O)CCC4)C3)C2)C1(C)C CC[C@@H1](CNC(=O)[C@]1(C)C=CCCC1)NC(=O)C2=CC(C)=C(Cl)S2 CN(CCCCN(C)C(=O)C(C)(C)S(C)(=O)=O)C(=O)C=1C=NN(C)N=1 CN1N=CC2=C1CN(C(=O)[C@@H1](N)[C@@H1](F)CC)CC2 C#CCCC(=O)N1C[C@H1](O)C[C@@H1](NC(=O)C=2SC=CC=2N3C=CC=C3)C1 CCC=1C(C(=O)N2[C@H1]3CC[C@H1]2[C@H1](C)[C@@H1](NC(=O)CCN4C=NN=N4)C3)=CSC=1C C[C@H1]1CCC=2C(C(=O)N(C)[C@H1]3CCN(C(=O)C=4N=NSC=4N)C3)=CSC=2C1 CSC1=CC=C(Cl)C(C(=O)N2CC[C@](O)(C(=O)NC3=CC(F)=C(F)C=C3I)C2)=C1 COC(=O)C1=CC=C(C(=O)N(C)[C@@H1](C)CNC(=O)[C@@H1]2CC(C)=NO2)C(C#N)=C1 C[C@H1]1OCC[C@]1(C)NC(=O)CCN2C=C(C3=CC(F)=NC=C3F)N=N2 CC1=CC=C2C=CC(C(=O)NC[C@@H1]3C[C@H1]3CNC(=O)[C@@]4(CF)CC4(F)F)=NC2=C1 CCN(CC)CC1=CC=CC(C2=CN=CC(C(=O)N3CC(C)C3)=N2)=C1 CCOC(=O)C(C)(C)C(=O)N(C)CCCNC(=O)C1=CC=NC2=CC(C)=CC=C12 CC1(OCC(=O)N2CCC[C@]3(NC(=O)C4=CN=C(S)N=C4)CCC[C@H1]23)CCCC1 NC(=O)C1=COC(C(=O)NC2(CNC(=O)C3=CC=C(NC=O)C=C3)CCCC2)=C1 C=CCN1C=C(C(=O)NC[C@@H1](NC(=O)C[C@H1](CN(C)C)C(F)(F)F)C2CC2)C=N1 CC1(C)CCCN(C(=O)C2=CCCS2)[C@H1]1CNC(=O)C3=C[C@@H1]4CCCC[C@H1]34 O=C([C@@H1](O)CC1=CC(Cl)=CC(Cl)=C1)N2CC(F)(C3=CC=CC(Br)=C3)C2 CSC1CC(C(=O)NCCCCCN(C)C(=O)[C@H1]2C[C@@H1]3CC[C@H1](C2)[C@H1]3O)C1 C#CCC[C@H1]1CCCN(C(=O)CCOCCCNC(=O)C2=CC=CC(OC)=N2)C1 C=C(C)COCC(=O)NC[C@H1](C)CNC(=O)CN(C)[C@@H1]1CCC[C@H1]1O CC1(C)[C@@H1](O)C[C@H1]1CC(=O)NC[C@]23CC[C@H1]2CN(C(=O)C4=CC=CC=C4F)C3 C#C[C@H1]1[C@H1](C(=O)N2CC[C@H1]2CNC(=O)C3=CC=NC=C3NC)C1(C)C CCSC1=CN=CC(C(=O)NCCN(CC)C(=O)C2=NC(Cl)=CC=C2N)=N1 CSCCCCC(=O)NCCC1CCN(C(=O)[C@]2(C)CCCN2C(C)=O)CC1 C#CC[C@@H1](O)C(=O)NCC12CC(CC)(CN1C(=O)C3=CSC(C4=CC=CO4)=N3)C2 CC1=C[NH1]N=C1C2=NC(C3=CC=C(OC(C)C)C=C3)=NN2CC(F)(F)C(F)(F)F CCC=CC(=O)NC1(CNC(=O)C2=CC=C(Br)O2)CCC1 CNS(=O)(=O)NCC(=O)NC1(CN(C)C(=O)CCC2=CC(Cl)=NO2)CC1 CC(C)(C)[C@@](C)(O)C(=O)OCC1=C(Cl)C=CC2=NC=CC=C12 O=C(CC1=CC=C2N=C[NH1]C2=C1)NCC3CN(C(=O)C4=COC5=C4CCCC5)C3 CCC1=NN(C)C=C1C(=O)NC(C)(C)[C@@H1](C)CC(=O)N[C@H1](C)C2=NN=C(O)N2C C#CC1=CN(C)N=C1C(=O)N[C@]23C[C@H1]2CN(C(=O)C4=CC(C)=C(Cl)C=C4OC)C3 C[C@H1](NC(=O)COCCCF)[C@@H1]1CCCN1C(=O)C2=C[NH1]C=C(Br)C2=O CCCN(C(=O)C[C@@H1]1CC=CCC1)[C@@H1]2CCN(C(=O)C=3SC=C(C)C=3Br)C2 CC1=NC=C(C(=O)N[C@H1]2C[C@@H1]3C[C@@H1](NC(=O)C4=CN=CC([N+1](=O)[O-1])=C4)C[C@@H1]3C2)O1 CCOC(=O)C1=CC=C(CN[C@H1]2C[C@H1](NC(=O)CCC(C)C)C2)C=C1 CC[C@@H1](CN(C)C)C(=O)N1C[C@@H1]2COC[C@H1](C1)C2NC(=O)[C@@H1](C)COC CC1=C(C(=O)NC[C@@](C)(O)C(F)(F)F)C=NN1CCN(C)C C[C@H1](C1=CC=C(N2CCN(C)CC2)S1)N(C)C(=O)NCC=3N=C(Cl)SC=3Cl C=C1CCN(C(=O)CCCN(C)C(C)C)[C@@H1](C(=O)NC[C@H1](O)COC(C)C)C1 C=C[C@@H1](C)CC(=O)N1CCCC[C@H1]1CNC(=O)C2=CC=CN=C2N O=C1NC[C@@H1]C2CCN(C(=O)C=CC3=CC=C(C4=CC=CC=C4)C=C3)[C@H1]1C2 CC1=NN2N=CC=CC2=C1C(=O)N[C@H1](C)C3CN(C(=O)C[C@]4(C)CCOC4)C3 CC(C)[C@H1]1CC[C@@H1](C(=O)N[C@H1](CO)[C@@H1](C)NC(=O)CSC2=NN=CS2)CC1 CC(=O)C1=CC(C(=O)N[C@H1]2CCN(C(=O)C3=CSC=4N=NSC3=4)CC2(C)C)=NO1 CCCCC(=O)N1CCC([C@@H1](C)C(=O)N[C@H1](C)CC=2N=CN(C)N=2)CC1 C[C@@]1(CNC2=CC=C(CCN3CCNC(=O)[C@H1]3CCO)C=C2)CCN4C=CN=C41 CC1=CSC(CCCC(=O)N2CC[C@@](CNC(=O)C[C@@H1](C)C(C)C)(C3CC3)C2)=N1 CC(C)OC1=CC=C(C(=O)N[C@@H1]2CN(CC3=CC=CN=C3Br)CCC2(F)F)C=C1 C[C@@H1](O)CC(=O)N[C@H1]1C[C@]2(CCCCN2C(=O)C3=CN=CC(Cl)=C3)C1 CC1=C[NH1]N=C1C(=O)NC(C)(C)CN(C)C(=O)[C@@]2(F)C[C@@H1]2C3=CC=CC=C3 C=C(CCNC(=O)[C@H1](C)SC(F)(F)F)CNC(=O)C=1N=C(C)N(C=2N=C[NH1]N=2)N=1 CCN1N=CC(C(=O)N2CCN(C(=O)C3=CC(F)=NC=C3OC)CC[C@H1]2C)=C1C C[C@H1](CNC(=O)C1=CC=CC2=CC=NN12)C(=O)NC3CC4(CC(O)C4)C3 CN1C=C(CNC(=O)C(=O)NC2=CC=C3C(=C2)CNC(=O)C3)N=N1 O=C(N[C@@H1]1C[C@H1]2CC[C@@H1]1C[C@H1]2NC(=O)C3=N[NH1]C=C3C4CC4)C5=CC=CN=C5 C[C@@H1]1OCC[C@@H1]1N(CCO)C(=O)[C@H1]2CCO[C@@H1]2C3=CC=C(Cl)C(F)=C3 CCCC(C)=CC(=O)NC1CCC(NC(=O)[C@]2(O)CCSC2)CC1 CN1CC2CC1(CN[C@H1]3CCN(C(=O)OC(C)(C)C)C(C)(C)C3(C)C)C2 CN1C(=O)OC[C@@H1]1C(=O)NC[C@@H1]2CC[C@H1]2NC(=O)C3=COC(C4CCC4)=N3 COCC1(C(=O)N2CC(NC(=O)COCC3CC3)(C4=CC=CC=C4)C2)COC1 COC1=CC=C(NC(=O)C[C@@H1](NC(=O)CCN2C=CC=C2)C3=CC=C(C#N)C=C3)O1 C=C1C[C@H1]1C(=O)NCC2=CN(C[C@@H1]3CCCN3C(=O)CC(C)(C)COC)N=N2 CC[S@](=O)CC(=O)NCC1(CNC(=O)[C@H1]2CN(CC)C3=CC=CC=C32)CC1 C=C(C)CNC(=NCCNS(=O)(=O)C=CC1=CC=CC=C1)N[C@H1]2C[C@@H1](OC(C)C)C2 CN1C(S)=NN=C1CC(=O)NC2[C@@H1]3CC(NC(=O)CC4=C[NH1]N=C4O)C[C@@H1]23 C[C@@H1]1OCC[C@@H1]1C(=O)NC2CC(C)(CNC(=O)C3=C[NH1]C(=O)C4=CC=NN34)C2 CC=1N=C(C(=O)N2CC[C@@H1](C3(NC(=O)[C@@H1]4CCCSC4)CC3)C2)SC=1C CCC[C@H1](CC(=O)NCCN(CC)CC)NC(=O)CN(C)C C=CC[C@]1(C(=O)N2[C@H1](C)C[C@@H1]2CO)CCCN1C(=O)C3=CCCCO3 CC[C@@](C)(CC(=O)NC[C@]1(F)C[C@@H1](NC(=O)C=CC2CCC2)C1)C(=O)OC CC1=CN=C(N(C)C[C@H1](C)CNC(=O)[C@]2(C3CC3)CCCO2)N=C1C CCCOCCC(=O)NC[C@H1]1OCC[C@H1]1C(=O)N2CCCN(C(C)=O)CC2 C=C[C@H1]1OCC[C@@H1]1C(=O)N[C@@](C)(CO)CNC(=O)CC2=CC=C(F)C=C2 CCSCCN=C1[NH1]C(N(C)CCCOC(C)C)=NC2=C1C[C@H1](C)CC2 CC(C)(C)OC(=O)N[C@@H1](CN1C=CN=N1)C(=O)N2CC[C@H1](CC(F)(F)F)C2 CC1(NC(=O)CCC2=CC=CO2)CN(C(=O)C3=CC=CC4=CN=NN34)C1 COCC(=O)NC[C@@]1(C(F)F)CCN(C(=O)[C@]2(CO)CCCO2)C1 CNS(=O)(=O)CC(=O)N[C@@H1]1C[C@H1]1CNC(=O)C[C@@H1]2CS(=O)(=O)C3=CC=CC=C32 CC1=CC(C)=C(C(=O)NC2CCC(CNC(=O)[C@H1]3OCC[C@H1]3C)CC2)[NH1]1 CCN1CCC[C@H1](C(=O)NCC[C@](CO)(C(=O)NC23CC(F)(C2)C3)C)C1 C[C@H1](NC(=O)[C@@H1](C)N(C)CC1=CC=CC=C1)C2=CC=C(N(C)C)N=C2 CC1(C)CC[C@H1](CNC(=O)[C@@H1]2C[C@H1]2C3CC3)N(C(=O)[C@H1](O)C(F)(F)F)C1 CC1=C(C(=O)NC[C@](C)(C(=O)N2CCOC[C@H1]2CCO)CCCCC)CO1 C[C@H1](OC1=CC=CC=C1C#N)C(=O)NC[C@@H1](C)N(C)C(=O)CC2=NC=CN2C C[C@@H1]1CCNCC[C@@H1]1N(CC2=CC=C(F)C(Br)=C2)C(=O)[C@@]3(C)CCCN3 CC1=CC(C#N)=CN=C1N2C[C@H1]3C[C@H1](NC(=O)C(C)(C)C(N)=O)C[C@H1]2C3 CN(C)C1=CC=C(C(=O)N2CC=C[C@H1](NC(=O)CCCCCC(C)(C)C)C2)C=N1 CN1CC2=CC=C(C(=O)N3CCCC[C@H1](NC(=O)CCC#N)C3)C=C2C1 CC[C@@]1(C(=O)N(C)CCOCCNC(=O)[C@H1](O)CC=2C=NN(C)C=2)CC1(F)F CC1=NC(N2CC3(C2)SCC[C@@H1]3NC(=O)C[C@H1]4C[C@H1](O)C45CCC5)=NC=C1Br CCC1=CC(F)=CC(COC(=O)CCCN(C)C(=O)OC(C)(C)C)=C1 CC=1[NH1]N=C(C(=O)N2CCC[C@@H1](C(=O)N3CC4=CC=CN=C4C3)CC2)C=1C CC1=CC=CC(Cl)=C1CC(=O)N2CC[C@]3(CCCN(C(=O)[C@@H1](C)CC(N)=O)C3)C2 O=C(NCCC=CBr)C=1C=NN(C2=CC=C(Cl)C=C2Cl)C=1 CC1=CC(OCC(=O)N[C@@H1]2CCOC[C@@H1]2C(=O)NCC3=NC=CC=C3O)=NO1 O=C(CCOC1CN(C(=O)C2=CCCCO2)C1)NC[C@@H1](O)C3=CC=CO3 COC1CCC(C)(C(=O)NC/C=C/CNC(=O)[C@@H1]2CSCC(=O)N2)CC1 C=CC[C@H1]1C[C@@H1](O)C[C@@H1](CC(=O)N2CCC[C@H1](NC(=O)C(C)(C)CF)C2)O1 CC(C)CC1(C(=O)N(CCNC(=O)CN(C)C2CCC2)C[C@@H1](C)O)CCCC1 C[C@@H1](NC(N)=O)C(=O)N1CCC(N2CCN(C(=O)[C@@H1]3CC=CC[C@H1]3C)CC2)CC1 CC(=O)OC1=CC=C(C(=O)NC2CN[C@H1](C(=O)NC3=CC=CC=C3)CC2)C=C1 N#CCCCC(=O)NC1(CNC(=O)COC2=CC=CC=C2Cl)CCCCCC1 CCN1CCOC[C@@H1]1C(=O)NCC2=CC=CC(CNC(=O)[C@@H1](O)C3CCCC3)=C2 C=CC[C@@H1](CC)C(=O)N[C@@H1]1C[C@H1](O)[C@H1]1CC(=O)N2CC=C[C@@H1](OC)C2 CC(C)=CC[C@@H1](C(=O)NCCCC1=CC=C2C(=N1)NCCC2)C3=CC=CC=C3 CC1=NO[C@](C)(C(=O)N2CC(NC(=O)[C@H1](C(C)C)N3C=NN=N3)C2)C1 CO[C@@H1](CCNC(=O)[C@H1](OC)C1CCC1)C(=O)N[C@@H1](C)[C@H1](C)F CC(C12)CCCC(C(=O)N3C[C@@H1]4C[C@]4(NC(=O)CO)C3)(C1)C2 C=C(CC)CN[C@]1(C2=NN=NN2CCCC3CC3)CC[C@@H1](CC)C1 CC1=CC=C(F)C(C(=O)N2C[C@H1](C)[C@H1](NC(=O)C3=CC(N)=C(F)C(F)=C3F)C2)=C1 CN(CCCCNC(=O)[C@H1]1CCCSC1)C(=O)C2=CN=C(N3C[C@H1]4CC[C@H1]3C4)S2 C=C=NC=C1OC(CNCC2=NC3=CC=C(Br)C=C3S2)=CC1=C COC1=C(C)C=C(CN(C)C(=NC[C@H1](C)N(C)C2CC2)NC(C)C)C=C1C COC1=CC=NC(OC)=C1C(=O)N2CC(O)(CNC(=O)[C@]3(C)C=CCCC3)C2 CC(=CC(=O)N[C@@H1]1CCCN(C(=O)C2=CC=CO2)C[C@H1]1F)C3=CC=CC=C3 NN=CC1=CC=C(C2(C(=O)NC3CN(C(=O)CC4CC4)C3)CCC2)C=C1 CCN1CC[C@H1](CN=C(NCC2(O)CCC2)N[C@@H1]3C[C@H1]3C(=O)OC)C1 CC(C)(C)C[C@@H1]1CN(CC2=CC=CC=C2)C[C@H1]1NC[C@](C)(F)C(F)(F)F COCCOCCC(=O)N[C@H1]1CCCC[C@H1]1C(=O)NC[C@@]2(C)CCC[C@H1]2O CC1(NC(=O)CCC2=CN=CS2)CCN(C(=O)[C@@H1]3CC[C@@H1]([C@@H1]4CCCO4)O3)CC1 CN1CC[C@H1](N(C)C(=O)[C@@H1]2CN(C(=O)C=3C=CC(=N)[NH1]N=3)CC(C)(C)C2)C1=O C[C@H1](CC(=O)NCC1=CSC(C(=O)N(C)CC2(O)CCCCC2)=C1)[C@@H1]3CCCO3 COCCN(C)CC1=CN(CCNC(=O)C2=COC(C)=C2[N+1](=O)[O-1])N=N1 CCN(C(=O)C1=CC=CC(C2(C)CC2)=C1)[C@H1](C)CNC(=O)[C@@]3(C)C=CCC3 CN1N=CC(Cl)=C1C(=O)N[C@@H1]2C[C@]23CCN(C(=O)C4=C[NH1]C(C#N)=C4)C3 C[C@H1](C(=O)O)C1=CC=CC(NC(=O)C2=CC=CC(Br)=C2N3CCCCC3)=C1 CC1(C)CC[C@H1](CNC(=O)[C@H1]2CCC=C[C@H1]2NC(=O)C=3C=C4N(N=3)CCC4)O1 CC(C)(CNC(=O)C1=C[NH1]C(C(N)=O)=C1)NC(=O)C2=CC=C(N)C3=CN=CC=C23 CC/C=C/C[C@H1](C)C(=O)N[C@H1]1CC[C@@H1]1C(=O)N(C)C[C@H1](C)C(C)C CSC[C@@H1](O)C(=O)N1C[C@@H1]2CC[C@H1](C1)C2NC(=O)[C@@H1](O)C3=CC=CC=C3 CCC1=NN=C2N1CCC[C@@H1]2C(=O)NC3(C)CN(C(=O)[C@]4(C)CCCOC4)C3 C[C@@H1](CCC(=O)NC[C@]1(F)C[C@@H1](NC(=O)C2=NC(O)=NC(O)=C2F)C1)N(C)C CCOC1=CC=CC2=C1OCC(C(=O)N[C@H1]3CCN(C(=O)[C@](C)(CC)OC)C3)=C2 COC=1N=C(C(=O)N2CC3(C2)CN(C(=O)[C@@H1]4CCC[C@H1]4C)CCO3)SC=1C CC[C@@H1](C)[C@H1]1CCCN1C(=O)C2=CC=C(CNC(=O)C3=C(Cl)CCOC3)C=C2 CC1=NC=NC(C(=O)N[C@H1](CC(C)C)C(=O)NC[C@H1](O)CN(C)C)=C1C COC(=O)C1=COC(CNC(=O)C(=O)N(C)CC2=CC=C(Br)C(F)=C2)=C1 C#CCCO[C@H1](C)C(=O)NC12CC(CNC(=O)C3=CC(C)=CC=N3)(C1)O[C@@H1]2C CC1=COC(C(C)(C)C)=C1C(=O)NCCC(C)(C)NC(=O)CC=2N=C[NH1]N=2 C=CCO[C@@H1](C)C(=O)N1[C@@H1]2CN(C(=O)C3(O)CC3)C[C@@H1]2C[C@H1]1C CCCN(C(=O)C1=CCOC1)[C@@H1]2CCN(C(=O)[C@@H1](O)C3=CN=CN3C)C2 CSSCC(=O)N1CC[C@H1](C)N(C(=O)CCSC2=N[NH1]C(C)=N2)CC1 C[C@H1](CCC1=CC=CC=C1)N[C@H1](C)CC(=O)C(F)(F)C2=CC=CC=C2 CC1=CC=C(C=2C=C(CN(C)C(=O)[C@H1](C)CF)[NH1]N=2)C=C1 O=C(NCCO[C@@H1]1CCN(C(=O)C2=NC=CC=C2F)C1)C=3[NH1]C=C4C=3CCCC4 CO[C@H1](C(=O)N1CCC[C@]1C2CCN(C(=O)CCCCCCCCCO)C2)C3CC3 CC1(C)CN(C(=O)[C@@]2(C)CCCO2)CC[C@@H1]1NC(=O)C3=CC=CC=4N=C(O)OC3=4 C[C@@H1](C[C@@H1](C)NC(=O)[C@H1](F)C(C)(C)O)NC(=O)C1=CC2=CC(F)=CC=C2O1 C[C@@H1]1CCCN(C(=O)CC2CC=CC2)[C@H1]1CNC(=O)C3=CC=C4C=CC=NN34 O=C(CCC1=CC=CS1)N2C[C@H1]3CCN(C(=O)[C@H1]4CC45CC5)C[C@@H1](C3)C2 C[C@]1(C(=O)NCCN(C(=O)C[C@H1]2NC(=O)C3=CC=CC=C32)C4CCCC4)C[C@@H1]1F C[C@H1](SC(F)(F)F)C(=O)N1CCC(C)(C)[C@H1](CNC(=O)CCCCN(C)C)C1 C#CCCC[C@H1](NC(=O)N1CCC[C@@H1]1C2=CC=C(Cl)N=C2)C3=CC=C(Br)C=C3 O=C(CC1=CC(Cl)=CS1)NCC2(NC(=O)CCC3CC3)CC4=CC=CC=C4C2 CC(C)CC1(C(=O)NCCCCCNC(=O)CCC2=CN(C)N=N2)CCCC1 CC1=CC=C(C(=O)N2CCOCC2)C=C1N3CCC4(CCCCCO4)CC3 C[C@@H1](CC(=O)N[C@H1](C)[C@@H1]1CCCN1C(=O)[C@H1](C)N(C)C)NC(=O)OC(C)(C)C CC(C)(CC#N)C(=O)NCCNC(=O)C1=CC=CC(F)=C1C(F)(F)F CC=1C=NN(C)C=1CNC(=O)C[C@@H1]2C[C@@H1](O)CN2C(=O)C=3N=C[NH1]N=3 CCC1=CC=CC=C1[C@H1](CNC(=O)C2=CN=C[NH1]2)NC(=O)[C@H1](C)CC(C)(C)C CN(CC1=CC=CC=C1N)C(=O)[C@]2(C)C=CCCC2 CC=CCCC(=O)N[C@H1]1CCCC[C@H1]1CNC(=O)CCNC(=O)C2=CC=CO2 CCC1=CC=C(C(=O)N2CC(CNC(=O)[C@@]34CC[C@@](C)(CO3)C4)C2)C(C)=C1 CCC1=CC(Br)=CC=C1N2N=C(CCN3C=NC=N3)N=C2C[C@H1]4COCCO4 CCCC1=CC=CC=C1NCC2=C(F)C=CC(OCC(=O)O)=C2F CC(C)=C(C)CC(=O)N1CCC[C@@H1]1C2(NC(=O)C=3C=NSC=3C)CC2 O=C(NC/C=C/CNC(=O)[C@@H1]1NC(=O)[C@@H1]2C[C@@H1]21)C3=CC=C(SC(F)(F)F)C=C3 O=C(CN1C=C(F)C=CC1=O)N[C@@H1]2C=CCN(C(=O)[C@@H1]3[C@H1]4CCCC[C@H1]43)C2 CCCN1C=C(C(=O)N(CCO)[C@@H1]2CCN(C(=O)C(F)(F)C(F)(F)F)C2)N=N1 C[C@@H1](C1=CC=CC=C1)N2N=C(C3=C4C=CC=CC4=NN3C)N=C2C[C@H1]5CC5(C)C C[C@H1](C(=O)NC1=CC=C(O)C=C1F)[C@@H1]2CCCN(C(=O)[C@H1]3CN4CC[C@H1]3C4)C2 CC=1N=C[NH1]C=1CCNC(=O)[C@@H1](NC(=O)C2=CC=CC(O)=N2)C3CCC3 CC=1C=C(CC(=O)N2CCCC3(CC(NC(=O)CSC(C)C)C3)C2)SN=1 C=CCO[C@@H1](C)C(=O)N1CCCC(N(CCF)C(=O)C2=CC=CC(OC)=C2C)C1 COCCCOCC(=O)N1CC[C@@H1](CNC(=O)CC2=CC=NN2C3CCC3)C1 CC1=NC=CN1[C@H1](C)C(=O)NC2CC(C)(C(=O)N(C)CCN3CCOC3=O)C2 C=CCNC(=O)[C@H1](C1=CC=C(S(C)(=O)=O)O1)N(C)[C@H1](C)C2=NN=CN2CC CCOC(=O)CC(=O)N1CCC[C@@H1](NC(=O)CC2=CC=C(Cl)C=N2)CC1 COC(=O)C[C@]1(C)CCN(C(=O)N[C@@H1](C)C=2C=CSC=2C#N)C1 CC1=CN=C(CCC(=O)N2C[C@H1](CO)C3(CCN(C(=O)[C@@H1]4C[C@H1]4F)CC3)C2)[NH1]1 CCC(=CC(=O)N[C@H1]1CC[C@]2(CC1)CN(C3=CC=NC(C)=N3)CCO2)CC N=C1[NH1]C(Cl)=C([N+1](=O)[O-1])C(=N[C@@H1](CNC(=O)CN2N=NC3=CC=CC=C32)C4CC4)[NH1]1 CN1CCN(C(=O)C2=CC=CC=[N+1]2[O-1])C[C@H1]1CNC(=O)[C@@H1]3CCCC34CCC4 CC1=CN=C(C(=O)N2CC[C@H1](NC(=O)C(=O)NC(C)C)C2(C)C)N=C1 COC1=NC=C(C(=O)N2C[C@H1](F)[C@@H1](C(=O)N(C)[C@@H1]3C[C@H1]3C4CC4)C2)S1 COC[C@]1(CNC(=O)[C@H1](O)C2=CC=CC=C2)CCCN1C(=O)C34CC(C3)[C@@H1](C)O4 F[C@H1]1CCC[C@@]2(CC[C@H1](NC3=CC=C(Cl)C=4C=C[NH1]C3=4)C2)C1 CC[C@@H1]1CC[C@](O)(C(=O)N2CC(C3(NC(=O)C=4C=COC=4CC(N)=O)CC3)C2)C1 C[C@@H1]1C[C@@H1]2CN(C(=O)CN(CC3CC3)C(=O)C4=CN=NC(O)=C4)C[C@@H1]21 O=C1C[C@H1](C(=O)N2CCC(C(=O)N3CCC[C@@H1](C4CCC4)C3)CC2)CCN1 CCN1C=CN=C1C(=O)N(C)C[C@@H1](C)NC(=O)[C@H1]2COC[C@H1]2NC(=O)OC(C)(C)C C#CC[C@@H1](C)C(=O)N1CCC[C@@](O)(CNC(=O)CN(CC)CC)CC1 CN(C)C[C@](O)(C(=O)NC[C@H1]1CCCC2=NC=CN21)C(F)(F)F O=C(CCCCC1CC1)NC[C@H1]2C[C@H1](CNC(=O)[C@@H1]3NC(=O)[C@@H1]4C[C@H1]43)C2 C#CC1=CC(C(=O)N2C[C@@H1]3C[C@@]3(CNC(=O)C#CC4(C)CC4)C2)=CC=C1Cl O=C(NCCC1(O)CCNCC1)[C@@H1]2C[C@@H1]2OCC3=CC=CC=C3 C[C@@H1]1CN(C(=O)C(=O)N[C@H1](C)C2=CC=C3C(=C2)CC(=O)N3C)CC[C@H1]1CN C#CC[C@H1](O)C(=O)N[C@@H1](CC#CC)C(=O)N(C)C[C@H1](O)COCC C=C(C)C(C)(C)C(=O)NC[C@@H1]1CN(C(=O)[C@@H1]2CO[C@@H1]3COC[C@H1]32)CCO1 COC1=CN=NC(C(=O)NC[C@@H1]2CCC[C@H1]2NC(=O)[C@@H1]3CC3(Cl)Cl)=C1 C#CC1(C)CC(NC(=O)N[C@@]2(C)CCCC[C@@H1]2C)C1 CCOC=CC(=O)NCC[C@@H1]1CN(C(=O)C2=NN(C)C=C2C#N)CCO1 C=CCC1(NC(=O)[C@@H1](O)[C@@H1](C)C2=CC=C(C)C=C2)CCN(C(=O)[C@H1]3C[C@H1]3F)CC1 COC1=CC=C(NC(C)=O)C(NC(=O)N2CC[C@H1](N3CCC3)C2)=C1 CC[C@@](C)(C#N)C(=O)NCC1(NC(=O)CC2(C)CCCCC2)CCC1 CC=1N=C(Br)SC=1[C@H1](NC[C@@H1]2CC[C@H1]2CO)C3=NN=NN3CCCF CCOC1(CNC(=O)[C@@H1](OC)C2CCC2)CN(C(=O)C3=CC=CC(NC)=N3)C1 CNC1=CC=C(C(=O)N2C[C@H1](O)[C@@H1](NC(=O)[C@@](C)(CO)OC)C2)C=C1F CCCCC1=NOC(CN2CC[C@H1]([C@H1]3CCCN(C(=O)C(N)=O)C3)C2)=N1 CCS(=O)(=O)C1=CC=CC(C#N)=C1S(=O)(=O)N2CC[C@H1](O)[C@@H1](CO)C2 COC1=NC(C(=O)N[C@H1](C)[C@H1](C)NC(=O)C#CC(C)(C)O)=CC2=CC=CC=C12 C[C@H1](C#N)CCC(=O)NCC(C)(C)CN(C)C(=O)[C@@H1]1C[C@H1]1C2=CC=CO2 C#CCN(CC(=O)N1C[C@H1](O)CC[C@H1]1C)C(=O)CCOC2CC2 C#C[C@H1](CC)CNC(=O)CC[C@H1](C)NC(=O)[C@@H1](CSC)OC CCCN(C(=O)C=1C=NN(C)C=1C#N)[C@H1](C)C(=O)NC2=CC=C(O)C(F)=C2 COC=1N=C(C(=O)N[C@@H1]2CCC23CN(C(=O)C4=NN(C)C(C)=C4Cl)C3)SC=1C CCC=1N=C(C)N(C)C=1C(=O)N[C@H1]2[C@@H1]3CN(C(=O)C4(C(F)(F)F)CC4)C[C@@H1]32 C[C@@H1](NC(=O)C1CCN(S(N)(=O)=O)CC1)C(C)(C)NC(=O)[C@H1]2C[C@@H1]3CC[C@H1](C2)O3 CC(C)C=1N=CSC=1C(=O)N(C)C[C@@H1](C)CNC(=O)CCCCCF CC[C@@H1](CNC(=O)C=1C=NN(CC)C=1C2CC2)NC(=O)C=CC3=CC=C(O)C=C3 CCCC=1OC=CC=1C(=O)N2CC(CNC(=O)C3=CC=CC(OCC)=C3N)C2 CN(C)C1=CN=CC(F)=C1[C@@H1](NCC2CCOCC2)C3=NN=NN3C4COC4 O=C(CCN(CCCO)C(=O)[C@H1]1C[C@H1]1Cl)NCC2=NC=CC=C2F CC=1C=C(F)SC=1C(=O)NC[C@@H1](C)CNC(=O)C2=CC=C(F)C(O)=C2F CCN(CC)CCC(=O)N[C@@H1](CN1C=CC=N1)C(=O)NC[C@H1]2COC[C@@H1]2N(C)C C[C@@H1](CCC(C)(C)C)NC(=O)[C@H1](CNC(=O)C1=C[NH1]C(=S)C=N1)N(C)C CC1(CNC(=O)C2(C)CCN(C(=O)C3C[C@@H1]4CCC[C@H1]4C3)CC2)CC1 NC(=O)[C@@H1]1CC[C@H1](C(=O)N[C@@H1]2C[C@H1]2CNC(=O)C3=CC(Cl)=CC=C3F)C1 CC(C)=C(C)C(=O)N1CC[C@H1](NC(=O)C2=CC(C3CCCC3)=NO2)C[C@H1]1C4CC4 CCCNC(=O)[C@H1](C)NC(=O)N[C@@H1]([C@H1](O)CO)C(F)(F)F N#CCCC(=O)N1C[C@H1](O)C[C@H1]1CNC(=O)CC2=CC(Cl)=CC3=C2OCC3 O=C(O)[C@H1]1C[C@@H1](C(=O)NCC2=CC=C(C3=CSC=N3)C=C2)C14CCCC4 O=C(NCC[C@H1]1CCCN1C(=O)CC=2C=CSC=2)C3=CN=C(O)N=C3O COC1=CN=CC=C1CN=C(NCC(F)(F)Cl)NC2[C@@H1](O)C[C@H1](C(=O)OC)C2 CCC=1C(C(=O)NC[C@H1]2C[C@@H1]2CNC(=O)CN3C(C)=CSC3=O)=CSC=1C C[C@H1]1C(C(=O)NCC2(NC(=O)C3=NOC4=NC=CC=C34)CCCCC2)[C@@H1]1C CC1=NN(C)C=C1[C@@H1](C)C(=O)N2CCC[C@]23CCN(C(=O)CCCCC(N)=O)C3 COC1(CNC(=O)C2=CC=CC=C2F)CN(C(=O)C[C@@H1]3CCCC[C@@H1]3F)C1 CC(C)(C)CC1CC(C(=O)NC23CC(CNC(=O)C4=CC=CC(N)=N4)(C2)C3)C1 CC[C@H1]1[C@@H1](C(=O)N2CC3(C2)CC(C)(F)C3)CCN1C(=O)C4=CC=NC(OC)=N4 C=CC=CCC(=O)N[C@@H1](C)C1(CNC(=O)COC2=CC=CC(C(C)C)=C2)CC1 O=C(NC[C@H1]1CC(F)(F)CN1C(=O)C2=CSC=C2Cl)C=3SC=C4C=3CCCC4 CC1=CSC(Br)=C1C(=O)N2CCC[C@H1]2CN(C)C(=O)C=3C=COC=3 CO[C@H1]1C[C@@H1](CC(=O)N2CC(OCCNC(=O)CSC3=N[NH1]C(O)=N3)C2)C1 CCCC1=NOC(CCC(=O)N[C@@H1]2C[C@@H1]3CN(C(=O)[C@H1](C)S(C)(=O)=O)C[C@@H1]32)=N1 O=C(N[C@H1](CF)C1=CC(Cl)=CC=C1Cl)C2=CC3=CC=C(Cl)C(F)=C3[NH1]2 COCC[C@H1]1CN(C(=O)[C@@H1]2CCN3N=CC=C3C2)CCN1C(=O)C=4C=CON=4 CNC(=O)NCC(=O)N[C@H1](C)C1=CC=C(CNC(=O)[C@H1](C)OCOC)C=C1 C[C@H1](CC(=O)N[C@H1]1CCN(S(=O)(=O)C(F)F)C1)C(F)F CCN1C=CN=C1CNC(=O)[C@@H1](NC(=O)COC(C)=O)C2=CC=CO2 CC[C@H1]1C[C@@H1]1C(=O)N2CC[C@H1]3CC[C@@H1](NC(=O)C4=NC=CC(N)=C4Cl)[C@H1]2C3 COCCN1C=C(C#N)C(=NC(=O)[C@H1](C)NC2=CC(C(F)(F)F)=CC=C2C(=O)OC)[NH1]1 CCC1CC(C(=O)N2CC[C@@](O)(CNC(=O)C34CC(C(F)F)(CO3)C4)C2)C1 CCOC(CC(=O)N1CC=C(C(=O)N[C@@H1](C)C2=CC=NC=C2)C1)OCC CC(=O)NC1=CC=C(C(=O)N2CCC[C@@H1]2[C@@H1]3CCN(C(=O)[C@H1]4CCO[C@@H1]4C)C3)S1 CC1=NC2=CC(C(=O)N3C[C@H1](C)[C@@H1](NC(=O)C=4C(C)=NSC=4N)C3)=CN=C2S1 O=C(N[C@@H1]1CCC[C@H1]1NC(=O)C2(F)CCCCC2)[C@H1]3CCN(CCO)C(=O)C3 CC1=CC(O)=C(C(C)C)C=C1C(=O)N2CCN(C(=O)C[C@H1](C)O)C[C@@H1](CO)C2 O=C(N[C@@H1]1C[C@@H1]2C[C@H1]1CN(C(=O)CNC3=CC=CC=C3[N+1](=O)[O-1])C2)[C@@H1]4CCCO4 CCN1C=C(CCNC(=O)[C@H1]2[C@H1](C)CCN2C(=O)CC=3C=CSC=3)C=N1 CC(C)C1=CC[C@@H1](NC(=O)C2=CCN(C(=O)[C@H1](O)CN3C=NC=N3)C2)CC1 COC[C@@H1](C)[C@@H1](C)C(=O)N1CC([C@@H1](C)NC(=O)C2=CC=CC=C2CN(C)C)C1 O=C([C@H1]1C=CCN1C(=O)C2=CN=C(C3CC3)O2)N4CCC[C@H1](CCO)CC4 CC1=NC(C(=O)N2CCOC3(CN(C(=O)C4=CC=CC5=C4CNC5=O)C3)C2)=CS1 CC(C)(C)OC(=O)CNC(=O)[C@@H1]1CN(C2=NC=C3C=C(Br)C=CC3=N2)CCN1 CCN(C(=O)[C@H1]1C[C@H1]2C[C@@H1]1CO2)C3CCN(C(=O)CN4C=C(C)C=N4)CC3 C[C@H1](CN(C)C)C(=O)N1CC2(CC[C@H1]2NC(=O)CN3C=NC(Br)=N3)C1 CO[C@@H1]1C[C@@H1](NC(=O)CCN2C=CN=N2)C13CCN(C(=O)CC4CC4)CC3 COCC[C@H1](C)C(=O)N1C[C@@H1]2C[C@@H1](NC(=O)C3=NC(O)=NC(O)=C3OC)[C@H1]1C2 O=C(N[C@@H1]1CN(C(=O)C2=CC([N+1](=O)[O-1])=C[NH1]2)CC13CCC3)C4=NN=CN4C5CC5 CC[C@@H1](CCCC(=O)N1CCC[C@H1]2[C@@H1]1CCN2C)NC(=O)CSC=3C=N[NH1]C=3 C[C@H1](CCNC(=O)[C@@H1]1CCC=2N=N[NH1]C=2C1)N(C)C(=O)C3=CC=C(NC=O)C=C3 COC1=CC=CC(N2C=C([C@]3(NC(=O)CS(=O)(=O)C4CC4)CCCOC3)N=N2)=C1 C[C@H1](C(=O)N1C[C@@H1](CNC(=O)C2CC(=C3CCC3)C2)C4(CC4)C1)N5C=CN=C5 NC1=NC=CN=C1C(=O)N2C[C@@H1]3[C@@H1](C[C@H1]3NC4=CC(O)=NC(O)=N4)C2 C=CCN1CCN(C(=O)[C@H1]2OCC[C@H1]2NC(=O)CC[C@H1](C)CCCC)CC1 C[C@H1](F)CC(=O)N1CCCC[C@@H1](NC(=O)CC2=NN=C(S)N2C)CC1 CC1=CC=C(F)C(C(=O)N2CCC(C)(C)[C@@H1](C(=O)N[C@H1](C)C(=O)NO)C2)=C1 O=C(C[C@H1]1CS(=O)(=O)CCO1)N2CC3(CCC3)C[C@@H1]2CNC(=O)C4(C(F)F)CC4 CCC(CC)CN1CC(=O)N(CC2(CO)COC23CC4CC(C3)CCC4)C1=O O=C(N1CCC[C@H1](CC2=CN(C3=CC=CC=C3CO)N=N2)C1)C(F)(F)CC4CC4 CC#CCCCC(=O)N1CCN(C(=O)C2=C(F)C=CC(Cl)=C2F)C[C@@H1]1CCO COC1=CN=C(C(=O)N2CCCC[C@@H1](CNC(=O)CCC3CCC3)C2)C(F)=C1 CCCN1N=CC(C(=O)NC[C@@H1](F)CNC(=O)C2=CC=C(OC)N=C2C)=C1Cl CC(=O)C1=CC(C(=O)NC2CC(CCNC(=O)C3=CC=CC=C3F)C2)=CC=C1O CC(C)(C)N(CCN)C(=O)NCCNC(=O)OCC1=CC=CC=C1 C[C@H1](CCCNC(=O)CCN1C=CN=N1)NC(=O)[C@@H1]2CCCN2CC(F)(F)F O=C(NC1[C@H1]2CC[C@H1]1CN(CC=3SC=NC=3Cl)C2)C4=CC=CC(C=5N=N[NH1]N=5)=C4 CCCC[S@](=O)C1=CC=C(C2=CC=C(NC(=O)C3=CSC=N3)S2)C=C1 C#C[C@H1]1CC[C@H1](C(=O)NC[C@H1](C)N(C)C(=O)C2=CC=CC([N+1](=O)[O-1])=C2O)CC1 COCC1=CN(C2CC(NC(=O)[C@@H1](C)NC3=NC=CS3)C2)N=N1 C#CC1=CC=C(C(=O)N2C[C@H1](NC(=O)C3(C(C)(F)F)CC3)CC[C@@H1]2C)N=C1 CS[C@@H1]1CN(C(=O)C2=NC=CN=C2N)C[C@H1]1NC(=O)[C@H1](O)C3=CC=C(Cl)C=C3 CN(C)C(=O)C(=O)N[C@@H1]1C[C@@H1](C(=O)N[C@H1]2CCCC=3OC=CC=32)C1(C)C CCC[C@@H1]1CCC[C@@H1]1CNC(=O)CCN(CCC)C(=O)C2=CC=C(CO)O2 CC1=NC=CC=C1NC(=O)[C@]2(CO)CCN(C(=O)CC[C@H1](C)N(C)C)C2 CCC(CC)CCCC(=O)NCC=1C=COC=1C(=O)N[C@@H1](C)C2=CC=NS2 CCOC(=O)[C@H1](C)CNC(=O)[C@H1](C)[C@@H1](C)NC(=O)CN1CCC[C@H1]1C CC1=CC=C2C(C(=O)NNC3=CC=NC(Cl)=C3F)=COC2=C1 COC1=CC(Cl)=C(Br)C=C1CNC[C@H1](F)C2=CC=C(F)C=C2 CNC(=O)CC1=CC=C(C(=O)N2CCCC3(CC2)N=N3)C=C1 CC1=CC=C(NCC(=O)N(C)CCCNC(=O)[C@@H1](C)CC(C)(C)C)C([N+1](=O)[O-1])=C1 C[C@H1]1CCCC[C@]1(CNC(=O)C2=CC=CC=N2)NC(=O)C3=NSC=C3Br CC[C@@H1](CNC(=O)[C@@H1]1[C@H1]2CC[C@@]1(C3=CN=CO3)C2)NC(=O)COC(C)=O CC[C@H1](C(=O)N1CC[C@H1]2CCC[C@@H1](C1)N2C=3C=CN4C=CN=C4N=3)C(C)C COC=1C(C(=O)N2C[C@H1](O)C[C@@H1](NC(=O)C3=CC=CN3C)C2)=CSC=1Cl C=C1CCN(C(=O)CN2C=NN=C2)[C@@H1](C(=O)NCC#CCOC)C1 CCC1(N(C)C(=O)C[C@@H1]2[C@@H1](NC(=O)CN3CSCC3=O)C[C@H1]2O)CC1 COC=1C=C([C@H1](C)NC2=CC=C(S(=O)(=O)N[C@@H1](C)CN3C=CC=N3)C(Br)=C2)SN=1 COCC1=CC=C(C(=O)N(C)CC(F)(F)CC(=O)OC)S1 CC1=CC(C(=O)N[C@@H1](C)[C@@H1]2CN(C(=O)CN3CC(C)C3)CCO2)=NC=C1C(N)=O CC1=CC[C@@](C)(C(=O)NC[C@@H1](NC(=O)C(C)(C)NS(C)(=O)=O)[C@H1](C)OC)CC1 C[C@](C(F)F)CNC1=CC=CC(S(=O)(=O)N[C@@H1]2CC23CCCC3)=N1 CCN1N=NC(C)=C1C(=O)N[C@@H1]2COC[C@@H1]2NC(=O)C3=CN(CC)N=C3C(C)C CCCN(CC(=O)NCCCS(C)(=O)=O)C(=O)CN1CCCC[C@@H1]1C CC[C@@H1](CC(=O)NCC(C)=CC(=O)N[C@@H1]1CCCN2C=NN=C21)C3CC3 NC1=CC=CC(C(=O)N2CC3(CC[C@H1](CNC(=O)C(F)(F)CO)O3)C2)=N1 CS[C@@H1](C(=O)NC[C@H1]1C[C@H1]1CC(=O)N2C[C@H1](C(N)=O)C3(CC3)C2)C4CC4 CCC[C@H1](C)C(=O)N1C[C@@H1]2CCC[C@H1](NC(=O)C3(C)CC(F)C3)[C@H1]2C1 CCC1=CC(C(=O)N[C@@H1](C)CN(C)C(=O)C=CC2=CN=CC(OC)=C2)=CC(O)=N1 CCC=1C=NN(CC(=O)N2CC[C@@](O)(CCNC(=O)C3CC(Cl)(Cl)C3)C2)C=1 C[C@H1]1CC2=CC(CC(=O)N[C@@H1]3CCN(C(=O)CSC(C)(C)C)C[C@H1]3O)=CC=C2O1 CN(C)CCC[C@H1]1CN(CC2=CC(C(C)(C)C)=N[NH1]2)CCO1 CCO[C@@H1](C(=O)NC[C@@H1]1CCN(C(=O)C2=C[NH1]C(=N)S2)C13CC3)C(C)C CN(CCNC(=O)C=1C=C(O)N(C)N=1)C(=O)CCOC2=CC=CC=C2Cl CN1CCC[C@@H1]1CN[C@@H1]2CC3(CCC3)CNC2 CC1=CC(CC(=O)N2C[C@H1](O)C[C@@H1]2CNC(=O)C3=CC=CC(C(C)C)=C3)=CC=N1 C[C@@H1](C(=O)NCC1(NC(=O)[C@H1](C)CN(C)C)CCC(F)(F)CC1)C=2C=CSN=2 CC1(C)CN(C(=O)C2=CC=C(O)C=N2)C[C@@H1]1C(=O)NCCC3=CC=CC=C3 CCO[C@H1](CN1CCN2C=CC=C2C13CCCC3)C4CC4 CSCCCCCC(=O)N1CC[C@@]2(NC(=O)C=CSC=3N=C[NH1]N=3)C[C@H1]2C1 CCC(CC)(CNC(=O)[C@@]1(O)CCOC1)NC(=O)C2=NC=CC=C2OC CCC[C@@H1](CC)C(=O)NC1=CC=C(NC(=O)[C@@H1](CC)OC)C=C1C CCC[C@H1](O)C(=O)N[C@H1]1[C@H1]2C[C@H1](CN(C(=O)C3=C(C)C=C(Cl)C=C3C)C2)[C@H1]1CO CC(C)(CC(=O)N1CC2(CC[C@H1]2NC(=O)C3=CC=4C=N[NH1]C=4C=N3)C1)C5CC5 CC=1SN=CC=1C(=O)NCCOCCC(=O)N[C@@H1](C)C2=CN=N[NH1]2 CC1=CN=C2N1CC[C@H1](C(=O)NC[C@H1]3CCN3C(=O)CN4C=NN=C4O)C2 C[C@@H1](COC1=CC=CC=C1)C(=O)NCCNC(=O)C=2C=C(C(F)F)N(C)N=2 CC1=CC=CC2=NC=NC(N[C@H1](C)CNC(=O)[C@H1]3CCCC4=CC=CC=C43)=C12 C=C[C@H1](C)C(=O)N1CC(=O)NC[C@H1]1C(=O)N2CC3(CCCC3)C2 CCC1(NC(=O)[C@@H1]2CCCC[C@H1]2OC)CCN(C(=O)C(C)(C)N(C)C)CC1 C[C@@H1](CN1C=NC=N1)N=C2[NH1]C(C3=CC=CC(Br)=C3)=NO2 C[C@H1](CNC(=O)C1=CN=N[NH1]1)CN(C)C(=O)[C@@H1]2CCCN2CC(F)(F)F C[C@H1](CCNC(=O)C(=O)NCC1CC1)NC(=O)[C@H1](F)C(F)(F)F CC1=CC(C)=CC(NC(=O)CC2=CN=C(C)S2)=C1O C=CC[C@H1](C)C(=O)NCCC(C)(C)NC(=O)C=1C=CN2N=CC(C)=C2N=1 C#CC[C@@H1]1CCCCN1C(=O)[C@]23CC[C@H1](C[C@@H1]2NC(=O)CCCCCC#N)C3 CC1=CSC(C(=O)N2CCN(C(=O)C=3SC(C(C)C)=NC=3C)C[C@H1]2C)=C1 CO[C@H1]1C[C@@H1](C(=O)NC2=CC=C(Br)C=C2CO)N(C(=O)C3=CC(Br)=CC=C3Br)C1 CC[C@]1(C)C[C@H1](NC(C)=O)CN1C(=O)C2=CN=C(C=3C=NN(C)C=3)S2 CN(C)C(=O)[C@H1](CO)NC(=O)C1=CSC(CNC(=O)C[C@@H1]2CC(=O)NC2=O)=C1 CCC1=CC(C(=O)NC[C@H1](C)N(C)C(=O)C2=CN(CC)N=C2C(C)C)=CC(C)=N1 CSCC1(C(=O)NC[C@]2(O)CCN(C(=O)CSCC3=CC=CC(Cl)=C3)C2)CCC1 CC1=C(CN=CC(F)(F)CCNC2CC2)OC3=CC=C(Cl)C=C13 C[C@H1](C(=O)N[C@@H1]1CCN(C(=O)CCC[C@@H1]2CCCC(=O)N2)C[C@@H1]1F)N3C=CN=N3 CS[C@H1](C)C(=O)N1CCN(CCNC(=O)[C@H1](C)C2=CC=CC=C2Cl)CC1 CC1=CC(NC(=O)NC2=CC=CC(OC(C)C)=C2)=NC3=CC=CC=C13 C=C[C@@H1](CC(=O)NCCNC(=O)C(C)(C)CC#N)C1=CC=C(OC)C=C1 CCOCC(=O)N1CC2(CCCN2C(=O)C3=CC=C(N4CCCC4)N=C3)C1 CC1=NC=NC(N2CCC(C)(C)[C@@H1](CNC(=O)[C@H1](C)N3C(=O)CCC3=O)C2)=C1F CC1=CC=C(C(=O)N[C@@]2(C(=O)N3CCC=C(C)C3)CC2(C)C)N1C C#CCOCCC(=O)N1C[C@H1]2CN(CC3=CC=C4C(Cl)=CC=NC4=C3)[C@H1]2C1 O=C(N[C@]12CCC[C@H1]1N(C(=O)CCC3=CC=CC=C3F)CC2)[C@H1]4CCCOCC4 CC1(C)CCO[C@@H1]1CCNC(=O)[C@H1]2CN(C(=O)CCCC#N)CCO2 COC(=O)[C@H1](C)C(=O)NCCC[C@H1](C)NC(=O)CN1C=CN=N1 CCCCC(=O)N1CCC(N2C=C(CNC(=O)C[C@H1]3CCCC34CC4)N=N2)CC1 CO[C@@H1](CCNC(=O)C=1ON=CC=1C)CNC(=O)CC2=NN=C(C)O2 COC1=NC=C(Br)C=C1CC(=O)N(C)CC(C)(C)NC(=O)C=2C=C(C)ON=2 C[C@@H1](CC(=O)NC1=CC=C(OCF)C=C1)C(C)(C)NC(=O)C2=CC(C)(C)C2 C[C@H1]1OCCO[C@H1]1C(=O)NC2(C(=O)NCC[C@@H1]3CCC[C@@H1]4C[C@H1]34)CCCCC2 C=C1CC(CN(C)C(=O)[C@H1]2C[C@H1]2CNC(=O)CCC(C)(C)OC)C1 O=C(CC1=C(O)N=CN=C1O)N[C@@H1]2CC[C@@H1]2NC(=O)C=3C=CN4C=3CCCC4 COC1=CC(C(=O)CNC(=O)[C@](F)(C2=CC=C(F)C=C2)C(C)C)=CC(OC)=C1O CCN1C=NN=C1C(=O)N[C@@H1](C)[C@@]2(O)CCN(C(=O)C=3SC=CC=3COC)C2 C=C1CC[C@@H1]1C(=O)N2C[C@H1](NC(=O)[C@@H1]3C[C@H1](C)CO3)CC(CC)C2 CN(C)C1=CC=C([C@@H1](CNC(=O)C2=C(Cl)CCOC2)NC(=O)C=CBr)C=C1 CCCSC1=CC=C(C(=O)N2CCC(C)(NC(=O)CCCCC(N)=O)CC2)C=C1 C#CCCC[C@@H1](C(=O)NCCOCC1=CC=CC=C1)N2CCS(=O)(=O)C[C@H1]2C CC1(COC(=O)C2=CC=CC(C3=NC(O)=N[NH1]3)=C2)CNC1 CC1CCC2(CC1)OC[C@H1](CN=C3C=CC4=CN(C(F)F)[NH1]C4=N3)O2 CC(C)OCC(=O)N1CCN(C(=O)C2=CSC(CS(C)(=O)=O)=N2)CC(C)(C)C1 CC1=CC=C(C2=CC=C(C(=O)N3CC[C@@H1](C4=CC=NN4C)C3)N=N2)C=C1 CC(=CC(=O)N1CC[C@@H1](OCC(=O)NC[C@]2(C)CCC(=O)N2C)C1)C3CC3 N#CC1=CC=C2N=C(NC(=O)[C@H1]3C[C@H1]4C[C@@H1]4N3S(=O)(=O)CCCCl)SC2=C1 CN(CC(=O)N1C[C@H1](CO)C2(C1)CN(C(=O)C3=CC(C4CC4)=NN3C)C2)C5CC5 CONS(=O)(=O)C1=CC=C(C(=O)N[C@@H1](C)CN(C)C(=O)C2(SC)CCC2)C=C1 CC1=C[NH1]N=C1CNC(=O)[C@H1]2CN(C(=O)CC[C@H1]3CC3(C)C)CC(C)(C)C2 CC=1N=C[NH1]C=1C(=O)N2CC[C@H1](NC(=O)CN3CCSCC3)CC(C)(C)C2 CC[C@H1](C1=CC=CC=C1)N2CC[C@H1](CC(=O)N(CCO)[C@H1](C)CC(C)C)C2 CN1N=C(O)C=C1C(=O)N[C@@H1]2CCC[C@@H1]2NC(=O)CC3CCCCC3 COCCC(=O)N1CCC[C@H1](C2CCN(C(=O)CCC=C(C)C)CC2)C1 CN(CC(C)(C)NC(=O)C1=CC=CC(C#CC2CC2)=C1)C(=O)[C@@H1]3CC34CC4 C#CC[C@H1](C)NC(=O)C1=CC=C(CNC(=O)[C@@H1]2C[C@H1](C)CO2)S1 O=C(N1CC[C@H1](OC2=CC=C(F)C=C2F)C1)[C@]3(C(F)(F)F)CCCCO3 C=C(Br)CCC(=O)N1CCC[C@@H1](N(C)C(=O)C2=CC=C(Cl)C=C2C)CC1 CSCC[C@H1](NC1=CC=C(Br)C(Cl)=C1C)C2=NN=NN2C[C@H1]3CCOC3 COCC1=NC=CC(N[C@@]23CC[C@@H1](C[C@H1]2NC(=O)[C@@H1](OC)C(C)C)C3)=N1 CN1C=CC=2[NH1]C(C(=O)N[C@H1]3C[C@@H1]3NC(=O)CSC4=CC=CC(F)=C4)=CC=21 C=C1[C@H1](NC(=O)NC[C@]2(C)CCCC2(F)F)C[C@H1]3C[C@@H1]1C3(C)C CC1=NC(C(C)C)=CC=C1C(=O)NC[C@@H1]2CC[C@H1](NC(=O)C(C)(C)C(F)(F)F)C2 CCCN=C(NC[C@@](C)(O)CNC(=O)OC(C)(C)C)N[C@@H1](C)C1=CSN=N1 CC(C)[C@](C)(CNC(=O)C1=CC=CN2C=CN=C12)NC(=O)C[C@H1]3CCN(C)C3 C=CC[C@@H1](CCNC(=O)C1(N(C(=O)[C@H1]2CN3CC[C@H1]2C3)C4CC4)CCC1)C5CC5 CC[C@@](C)(C(=O)O)N(CC1=CC=CC=C1)C(=O)C=2C=NC3=NC=CN3C=2 CC=1C=C(C(=O)N2CC[C@@H1](NC(=O)C3=CSC(S)=N3)[C@H1](F)C2)N4N=CC=C4N=1 C=CCOCCCC(=O)NC1=CC=CC(CNC(=O)[C@@H1]2CCCOC2)=C1 CC1=NSC=C1CC(=O)N[C@H1](CCN(C)C(=O)CN2[C@@H1](C)CC[C@@H1]2C)C(C)C C[C@@H1](CNC(=O)CNC(=O)C1=C(F)C=CC=C1F)NC(=O)[C@]23CCCC[C@H1]2OC3 CCOC1=NC(C(=O)N2CCCC23CCN(C(=O)[C@@H1]4[C@@H1]5C[C@H1]5[C@H1]6C[C@H1]64)C3)=NS1 O=C(C1=CC=C(CF)C=C1)N2CC[C@H1]3[C@@H1](C2)CN3C(=O)[C@@]45CC=CCN4CCC5 COC[C@H1](O)C(=O)N[C@]1(CNC(=O)[C@@H1]2CCOC(C)(C)C2)CC3CCC1CC3 CC1=CC=CC([C@@H1](C)NC(=O)[C@@H1](C)CNC(=O)CSC=2N=C[NH1]N=2)=C1 CO[C@@H1](C)C(=O)N1CC(N(C)C(=O)C[C@H1]2CCNC(=O)C2)C1 CCCOCCC(=O)N[C@H1](CNC(=O)CCCCCOCC)C1=CC=C(F)C=C1 CCCCS[C@H1](C)C(=O)N[C@@H1](COC)C(=O)NCCC1(O)CCCCC1 COC1=CC(Cl)=CC(CC(=O)NC[C@@H1](C)C2CCN(C(=O)[C@@H1](C)SC)CC2)=C1 CCN([C@H1]1CCOC1)[C@H1](C(=O)NCCSC)C2=NOC3=C2CCCC3 CC1=CC(C(=O)N2CCCN(C(=O)[C@]3(O)C[C@H1]4CC[C@H1]3C4)C[C@H1]2C)=CC(C)=C1O CO[C@@]1(CC(=O)N[C@@H1]2CCN3CC[C@H1]2C3)C[C@@H1]4[C@H1](C)CCCN4C1 COC1=CC=C(C(=O)NC=2SC(C3=CC=C(OC)C=C3CO)=NC=2C)C=C1 CC[C@@H1](O)CCNC=1[NH1]C(=NC[C@H1]2CCCC3=CC=CC=C32)N=C4SC=NC=14 C[C@H1](CCNC(=O)[C@@H1]1CN(C(=O)[C@@H1]2CCC(=O)N(C)C2)CCC1(C)C)C(F)F CCN1C=C(C(=O)N[C@@H1]2CCN(C(=O)C3=CC=CC(F)=C3Cl)C[C@H1]2O)N=N1 CCCC[C@H1](CC)C(=O)N1CC[C@@](C)(CC(=O)NCCN2CC[C@@H1](OC)C2)C1 CO[C@H1](CSC)C(=O)N1CCC[C@H1](N(CCO)C(=O)CC2=CSN=N2)C1 CN(CC1(NC(=O)[C@H1]2CCCO2)CC1)C(=O)C3=CC=C4C(=N3)CCCC4 CC=1SC(Br)=NC=1CC(=O)N[C@@H1](C)CNC(=O)C2([C@H1]3CCCO3)CC2 CO[C@H1]1CC[C@H1](C(=O)N2CC3CC2(C(=O)N4CC(CF)C4)C3)C1 CC1(CC(=O)N2C[C@@H1]3CC[C@H1]CN(C(=O)C(F)(F)C(F)(F)F)C[C@@H1]3C2)CCCC1 CCN(CC(C)(C)CNC(=O)CC1=CC=C(Cl)N=C1)C(=O)[C@H1]2C[C@H1](OC)[C@H1](OC)C2 CCC1=CC(C(=O)N2CC[C@](O)(CN(C)C(=O)C3CCCCCC3)C2)=CC=C1Cl CC1=CC=C(C(=O)NCCC[C@@H1](CO)NC(=O)[C@@H1](C)CC(F)(F)F)N=C1O CC1(C)OC(=O)C[C@H1]1C(=O)N2C[C@@H1](NC(=O)C3=NSN=C3O)CC[C@@H1](O)C2 CC[C@H1](O)[C@@H1](C)C(=O)N(C)CC[C@@H1]1CCCCN1C(=O)C2CCCC2 CCC1=NO[C@H1](C(=O)N[C@H1]2CC[C@@H1](N(C)C(=O)[C@H1]3CCC(=O)NC3)CC2)C1 C[C@@H1]1CCN(C(=O)CC2=CC=CC(F)=C2)C[C@H1]1CC(=O)N[C@H1]3CC[C@H1](O)C3 C[C@@H1]1CCN(C(=O)C=CCOC2CCOCC2)[C@H1]1CNC(=O)CCC(C)N(C)C C#CCCCCCCC(=O)NC[C@H1](CO)CNC(=O)[C@]1(C)CC1(C)C CCC=1N=NSC=1CNC(=O)[C@H1](CC(N)=O)NC(=O)[C@@H1](C)N2C=NC=N2 CCC=1N=C[NH1]C=1C(=O)N[C@H1]2CCC[C@H1](CN(C)C(=O)C3(F)CC3)C2 COC1=CC=C(NC(=O)CN=C2C=C[NH1]C(=NCC[C@@H1]3CCCN(C)C3)[NH1]2)C=C1 CC1=CC(C(=O)N[C@]23C[C@H1]2[C@@H1]4CC[C@H1](C3)N4C(=O)C5=C(N)C=NC=C5F)=NO1 CCCC[C@H1](O)CC(=O)N(CC)C1CCN(C(=O)C2=CC=C(C(C)=O)C=C2)CC1 C=C(C)CNC(=O)[C@@H1](C1=N[NH1]C(CC)=N1)N2CCN(C3=CC=CC(O)=N3)CC2 CC1=CC=CC2=CC=C(C(=O)O[C@H1]3COC(C)(C)C3)N=C12 CN(C)C(=O)C(=O)NC[C@H1]1[C@@H1](C(=O)N2CCC(OC3CC3)CC2)C1(C)C C#CC[C@H1](O)C(=O)N[C@]12CC[C@H1]1CN(C(=O)C3=C[NH1]C=C(C)C3=O)C2 CC1=CC(C(=O)NC[C@H1]2CN(C(=O)CN3N=NC(C4CC4)=N3)CCCO2)=CO1 CN1N=C(CNC(=O)COCC(F)(F)F)C2=C1CCN(C(=O)C(C)(F)F)C2 COC1=CC(C)=NC(NNC(=O)C(=O)NC2=CC=C3C(=C2)CC[C@@H1]3N(C)C)=N1 O=C(NC[C@H1]1C[C@H1]1NC(=O)C2=CC=C(F)C=C2Cl)C3=CC(F)=C(Cl)C(N)=C3Cl CC(C)[C@@H1](C(=O)N[C@H1]1C[C@@H1](CNC(=O)C2=CC=C(C#N)C=C2)C1)N3CCCCC3 CC[C@@H1]1CN(C(=O)C2=CC(C)=CC=N2)CC[C@@H1]1NC(=O)[C@@H1]3CCOC3(C)C CC#CC[C@H1](NC(=O)C#CC1CCCCC1)C(=O)N2CCSC[C@@H1]2CO C#CCCC(=O)N1CC2(CCN2C(=O)CC3(C(F)(F)F)CCC3)C1 CC=1C=C(C(=O)NC[C@@H1](NC(=O)C23CC4C[C@H1]2[C@H1]3C4)C(C)C)[NH1]C=1C C#CC1=CC=C(C(=O)N2C[C@](C)(C(=O)N[C@H1](CC)C(C)(C)C)CC2(C)C)O1 CC1=CSC=C1C(=O)N[C@@H1](CN2C=CC=N2)C(=O)N3C[C@H1]4CCCC[C@H1]43 CC(Cl)=CC(=O)NC[C@@H1](C1CC1)N(C)C(=O)C=2SC(C3=CC=C(C)O3)=NC=2C CCC(C)(C)C(=O)N[C@@H1]1CC[C@@H1](C)N(C(=O)[C@H1](C)OC2=CC=C(Cl)C=C2)C1 CC1=C[NH1]C=C1C(=O)N2C[C@@H1](N(C)C(=O)C[C@@H1](C)CN(C)C)C3(CC3)C2 COCCN(CCNC(=O)[C@@H1]1CN2CCN1C[C@@H1]2C)C(=O)[C@H1]3CC(=O)[C@H1]3C C#CC1=CC=C(C(=O)N2CCN(C(=O)C[C@H1](C)OC)C[C@@H1]2C3=CC=CC=N3)O1 COC1(C(=O)NC[C@H1]2CCC[C@@H1]2C(=O)NC[C@@H1](SC)C3CC3)CC1 COC(OC)C(=O)NCC12CC(NC(=O)[C@@H1]3C(F)(F)C34CCC4)(C1)C2 C=C(C)CN1N=NN=C1[C@H1](C[C@@H1]2CCCCC23CC3)NC[C@@H1](C)N4CCCC4 CC1=CSC(Cl)=C1C(=O)NCC2(NC(=O)CCCN3CCCC3)CC2 C=CCCC(=O)N1[C@H1]2CC[C@H1]1CC(C[C@H1](C)NC(=O)C3(C(=O)N(C)C)CC3)C2 C[C@@H1]1OCCC[C@@H1]1C(=O)N2C[C@@H1]3CC[C@H1](C2)N3C4=CC=CC(F)=C4C#N COC1=NN(C)C=C1C(=O)N[C@@H1](C)CCNC(=O)CC2(C#N)CC2 CC=1C=C(C)N(CC(=O)N2CC[C@@H1](F)[C@@H1](NC(=O)C3=CC(O)=NC(Cl)=C3)C2)N=1 CCC(CC)CC(=O)N1C[C@H1](O)CC[C@@H1]1C(=O)N[C@@H1]2CCOC2=O C[C@@H1]1CN(C)C[C@@H1](C(=O)N2CC[C@@H1](NC(=O)C3=CCCC(C)(C)C3)C2(C)C)O1 O=C(CC1=CC=NO1)N2CCC[C@H1](CN3C=C(C4=CC=C(C(=O)O)C=N4)N=N3)C2 CCOC(=O)[C@@H1](C)CNC(=O)C[C@H1](NC(=O)CCCOCCOC)C(F)(F)F C=CC[C@H1](CC)C(=O)N[C@H1](CNC(=O)C1=CC(C)=C(Br)C=C1C)C(C)(C)C CCCC[C@@H1](NC(=O)C1(C2=CC=CC=C2)CC3(CC3)C1)C(=O)OC(C)C O=C(NC[C@@H1]1CN(C(=O)C[C@H1]2CCCOC2)C[C@H1]1O)C3=C(F)C=CC=C3C4CC4 C[C@@H1](CF)C(=O)N[C@@H1]1CC[C@H1]1CNC(=O)C2=CC(C3(C)CC3)=N[NH1]2 CC(C)(C)S(=O)(=O)CC(=O)N[C@@H1]1[C@H1]2CCN(C(=O)CNC(=O)C3=CC=CN=C3)[C@H1]21 CC1(C)CC[C@@H1](CNC(=O)CS(C)(=O)=O)N(C(=O)CN2N=CC3=NC=CC=C32)C1 O=C(C=C1CCC1)N[C@H1]2CC[C@@H1]2C(=O)NCC=3C=CN(C4CC4)N=3 CC=1SC(C(=O)NC[C@](C)(O)CNC(=O)C=CC=2C=NN(C)C=2C)=C(C)C=1C CN1C=C(C(=O)NCC(C)(C)CNC(=O)[C@H1]2C[C@@H1]3CC[C@H1](C2)O3)C(C(F)F)=N1 CSCCCNC(=O)[C@@H1](CC1CCCCC1)N2CCC[C@H1]2CCO C=C[C@@](C)(CCOC)C(=O)NCC(C)(C)CNC(=O)CC1=CC(Br)=CS1 COC[C@@](C)(O)CC(=O)NC[C@H1]1[C@@H1](C)CCCN1C(=O)C=CCOC2CCOCC2 C=CCC1(C(=O)N2CC[C@@H1](C)[C@@H1](CNC(=O)CCC)C2)COC1 CCN(C)C[C@@H1]1CCN(C(=O)/C=C/CNC(=O)CC=2C=C[NH1]C=2)C1 COC(=O)C1=CC=CC([C@H1]2C[C@H1](NCCC3CCC(C)(C)CC3)C2)=C1 CC1=NC(=N)[NH1]C(=NC[C@]2(F)C[C@H1](NC(=O)[C@H1](F)C3CCOCC3)C2)[NH1]1 CO[C@H1](CC1CCC1)C(=O)N(C)C[C@@H1](O)CNC(=O)C[C@@H1]2CC(=O)NC2=O CCC[C@@H1](C(=O)N1C[C@@H1](CNC(=O)CN=C2C=C[NH1]C=C2)C3(CCC3)C1)N(C)C NC(=O)C1=CC=CC(C(=O)N[C@H1]2C[C@@H1](CNC(=O)C3=C[NH1]C4=CC=CN=C34)C2)=C1 C=C[C@](C)(CCOC)C(=O)NC[C@H1]1CCCC[C@H1]1NCC=2C=NSN=2 CC1=CC(C)=NC(C(=O)N2C[C@H1](O)[C@H1](NC(=O)CC3=CSC(C)=N3)C2)=C1 CC(C)(CCCNC(=O)C1=CC=CC(N)=C1O)NC(=O)C2=CC=C(F)C(CO)=C2 COC1=CC=C2N=C([C@@H1](NCCCO)C3=NN=NN3C[C@@H1]4CCOC4)SC2=C1 O=C(NC1=CN=C(C(F)(F)F)S1)N2CCN(C3=CC=CC([N+1](=O)[O-1])=C3)CC2 CC#CC[C@@H1](NC(=O)CCC1=CN(C)N=N1)C(=O)N[C@@H1]2CC(=O)N(C3CC3)C2 CC1=CC=C(CSCC(=O)NCC[C@]2(C)CCN(C(=O)[C@H1]3CC3(C)C)C2)C=C1 CC/C=C/C[C@H1](C)C(=O)N(C)[C@H1](C)CCNC(=O)C=1C=NN(CC)C=1 CCCCC(=O)N[C@@H1](CCN(C)C(=O)[C@@H1]1CCCN1C2CCCCC2)C(C)(C)C CCCC[C@H1]1CN(C(=O)[C@@H1]2CC(=O)N2)CCN1C(=O)[C@@H1](COC)CC(C)C CCC1=CC=C(NC(=O)C(=O)N[C@@H1]2CCN(C)C2(C)C)C=N1 C[C@@H1]1C[C@@]2(CCN(C(=O)C3=CC=CN=C3N4C=CN=N4)C2)CO1 O=C(CC1(CO)CC1)NC[C@@H1]2CCN(C(=O)C3=CSC=C3F)CC2(F)F C[C@H1](N=C1N=C2SC=CC2=C(N3CCC(C)(F)CC3)[NH1]1)C4=CC=CC=N4 COCCNC(=O)[C@H1](C1=CC(C(C)C)=NN1C)N2CCO[C@@H1]3CCCC[C@H1]32 CC1=CN=NN1CCNC(=O)[C@H1](C)N(C)C(=O)C2=CC(C#N)=CO2 C#CCN(C(=O)[C@H1]1CCCC1(C)C)[C@@H1]2CCN(C(=O)C3=NC=NC=C3N)C2 COC1=CC=C(C(=O)N2CC[C@H1](C3(NC(=O)C4=CN=CC(Cl)=C4Cl)CC3)C2)C=C1 CC1(CNC(=O)[C@H1]2CCCCN(C(=O)C3=CN=CC=4[NH1]C=CC3=4)C2)CCCCC1 C[C@H1]1CN(C(=O)CN(C)C2CCCC2)C[C@H1]1NC(=O)C(=O)C3=CC=C(F)C(F)=C3 CCOC(=O)[C@@H1](OC)C(=O)N1CCN(C(=O)C2=CC=NN2CC)[C@@H1](CC)C1 C=CC[C@H1](CNC(=O)C1=CC=C2C=CN=CC2=N1)NC(=O)C=3SC=NC=3COC COC(=O)C1=CC=CC(NC(=O)C2CN(C(=O)C3=CC=C4[NH1]C=CC4=N3)C2)=C1 CCC[C@H1](CC)CCC(=O)N1CC2(CC(NC(=O)C=CC3=CC=NC=N3)C2)C1 CCC1=CN=CC=C1C(=O)N[C@]23CCC[C@@H1]2CN(C(=O)C4=CC=CC(F)=C4)C3 C[C@H1](CNC(=O)C1=CC(Cl)=C2[NH1]C(O)=NC2=C1)NC(=O)[C@H1]3CCC[C@H1](O)C3 COCCCN1C=C(C(=O)NC2CCN(C3=NC=C(C#N)C=C3F)CC2)C=N1 CC(CCCNC(=O)C(C)C1=CC=CC=C1[N+1](=O)[O-1])NC(=O)C(F)=CC2CC2 CCCCN(CCO)C(=O)C1=CC(OC)=NC=C1C2=CC=C(F)C(F)=C2CO CC(C)N1C=C(NC(=O)[C@](C)(CO)NC(=O)C2=COC(N(C)C)=N2)C=N1 CN1C=CC(=O)C(C(=O)NC2(CCCNC(=O)[C@@]34CSC[C@H1]3C4)CC2)=C1 C[C@@H1]1CN(C(=O)CC2=CC=C(Cl)C=N2)CCN1CC(F)(F)F CN(C)C[C@@H1](NC(=O)[C@H1]1CCNC(=O)C1)C(=O)NCC2=CC=CN=N2 CCC[C@](C)(CC)C(=O)N1CCC(F)(CNC(=O)C2=C[C@H1]3C=C[C@H1]2C3)CC1 C=CCN(C)CCN(CC)C(=O)C1=CN=CC(OC(C)C)=C1 C[C@@H1](CCNC(=O)C1=CN=C(C(F)F)N=C1)NC(=O)C=C2CCCCC2 NC(=O)[C@@H1]1CC[C@@H1](CNC(=O)C#CCNC(=O)C2(C3=CC=CC=C3)CC2)O1 C#CC[C@H1](O)C(=O)N[C@@H1](CC(N)=O)C(=O)NC[C@](C)(CO)COC CN(C(=O)CN1CC=CC1)C2CCN(C(=O)C[C@@H1]3CCCC(C)(C)C3)CC2 COCCN(C)C(=O)C1(NC(=O)C2=NC=CN2C)CC(CO)C1 CCC1=CC(C(=O)N2CC=C[C@H1]2CNC(=O)[C@@H1](C)COC)=CN(C)C1=O O=C(NC1CN(C(=O)[C@H1]2CC(C3=CC=CC=N3)=NO2)C1)[C@@H1]4CC5(CCCC5)CO4 CCC1CC(C(=O)N[C@H1]2CC[C@@H1](NC(=O)[C@H1]3CC[C@@H1](C(N)=O)N3C)C2)C1 C#CC[C@](C)(CC)C(=O)NC[C@@H1](O)CN(C)C(=O)C1=CC=CC(F)=C1Cl C[C@H1]1[C@H1](C)CN1C(=O)CCCC(=O)C2=CC=C(F)C=C2 COC1=CC=CC=C1CC(=O)N(C)C[C@@H1](C)CNC(=O)C[C@@H1](C)C2=CC=NC=C2 C[C@H1](C(=O)NC[C@H1]1CCCCN(C(=O)C[C@@H1]2CCCC3(CC3)C2)C1)[C@@H1]4CCOC4 CCCC[C@@H1](CNC(=O)C(C)(C)CC(F)F)NC(=O)CN(C)C1=CC=C(Cl)C=C1 CC[C@@H1]1C[C@H1]1C(=O)N[C@H1](CNC(=O)C2=CC(F)=C(C#N)C(F)=C2)C(C)(C)C CCC=CC(=O)NC/C=C/CC(=O)NC(COC)COC CC(C)N1N=NC=C1C(=O)N2CC(C[C@H1](C)NC(=O)C3=CC=CN(C)C3=O)C2 CC#CCCCC(=O)N[C@H1]1C[C@@H1]1NC(=O)[C@@H1](C)C2=CC=C(Cl)C(Cl)=C2 CC(C)(C)C1=NC=C(C(=O)NCC[C@H1]2CCN(C(=O)[C@H1]3CCSC3)C2)[NH1]1 CSCC(NCC1=CN=C(O)C2=CC=CC=C12)(C3=NN=NN3CC(F)F)C4CC4 C[C@@H1]1C[C@@H1](NC(=O)C2=CC=C(Cl)N=N2)CN1C(=O)CC3=CC=C(F)C=C3F CC[C@@H1]1CC[C@H1](C(=O)N[C@H1]2CN(C(=O)C3=NC(Cl)=C(Cl)S3)C(CC)(CC)C2)O1 CCCN=C(NCCCCC1(C)OCCO1)N[C@H1]2CCO[C@@H1](CC(C)C)C2 C[C@@H1](NC(=O)C1=CC=C(CNC(=O)[C@H1]2CCN(C)C2)C=C1)[C@@H1]3CCCO3 CCN1C=C(C(=O)N2CC[C@@](CNC(=O)C(C)(C)COC)(C(C)(C)C)C2)C(C)=N1 CN1CCC[C@H1](C(=O)N2CC[C@@H1](N(C)C3=CC4=NN=CN4C(C)=N3)C2)C1 C[C@]1(NC(=O)CCCC2=CC=CC=C2N)CCN(C(=O)COCC=3N=C[NH1]N=3)C1 C[C@H1](C(=O)NCC1=CC=CC(Cl)=C1)N2CCC[C@@H1]2C3=CC=C[NH1]3 COCC[C@@H1](OC)C(=O)NC(C)(C)CNC(=O)[C@H1](C)OC1=CC=C(Cl)C(Cl)=C1 CCC(C)(C)[C@H1](C)NC(=O)CC1(N(C)C(=O)[C@@H1]2CC3=NC=CN3C2)CC1 O=C(NCCOCCN=C1N=C(C2CCCC2)[NH1]S1)[C@@H1]3C[C@@H1]4CCCCN4C3 C#CCCO[C@@H1](C)C(=O)N1CC=C[C@H1](NC(=O)C=CC2=CC=C(F)C=C2F)C1 CS[C@H1](C(=O)NC(C)(C)CNC(=O)[C@H1](C)CNC(=O)OC(C)(C)C)C(C)C CC(C)(C)CC(=O)NC1=NC(CN(CC(N)=O)C2CC2)=CS1 CC[C@]1(C)CC[C@H1](C(=O)N2CCC3(CC2)CN(C(=O)C[C@H1]4C[C@H1]4C)C3)O1 CN(C[C@@H1]1CCCN(C(=O)/C=C/COC(C)(C)C)C1)C(=O)[C@@H1]2[C@@H1]3CCC(F)(F)[C@@H1]32 C#CCCCCC(=O)N1CCN(C(=O)C=2OC(Br)=NC=2C)C[C@H1](O)C1 C=CCCC1(C(=O)N(C)C[C@@H1]2CCCS2)CN(C(=O)C=3OC(C)=NC=3C)C1 C[C@]1(CN=C2[NH1]C(=NCC(Cl)Cl)[NH1]C3=C2CCCCC3)CS(=O)(=O)CCO1 C#CCCOCC(=O)N1CCN(C(=O)[C@@H1]2CCCC3=NC=CN32)C[C@H1]1C(C)(C)C CS[C@H1](C(=O)N[C@@H1]1CC[C@H1]1CNC(=O)C2=CN=CC3=C2CCC3)C(C)C C[C@H1](C(=O)N[C@@]12C[C@@H1]1CN(C(=O)C3=CC(N)=CC=C3Cl)C2)N4CCN(C)CC4 CC1=NC(CN2CCO[C@]3(CCCN(C(=O)CCCCN4CCCCC4)C3)C2)=CO1 CC1=CC=NC(C(=O)N2CCO[C@@H1](CCCNC(=O)C3=C[S@@](=O)CCC3)C2)=C1 CC1=CC(C(=O)N2CCN(C(=O)[C@H1](C)CC=3C=NN(C)C=3)C4(CCC4)C2)=CC=N1 N=C1[NH1]C=NC=C1C(=O)N2C[C@H1]3[C@H1](CC(=O)N4CC[C@H1](CO)[C@@H1](O)C4)[C@H1]3C2 CN1C[C@H1](C(=O)N2CCC[C@@H1]2CN(C)C(=O)C3=CC=CN=C3)C4=CC=CC=C41 CC=1N=CSC=1CCC(=O)NC[C@@]2(O)CCN(C(=O)C3(O)COC3)C2 C#CCCC(=O)N1C[C@@H1](NC(=O)/C=C/C(=O)C2=CC=C(F)C(F)=C2)CC1(C)C CCN(C(=O)C1=CC2=C[NH1]C=NC2=N1)[C@@H1]3CCN(C(=O)C[C@@H1]4CCNC4=O)C3 CCOCCC(=O)N1CC(C(=O)N[C@@H1]2CCC[C@H1]2C3CC3)(C4CC4)C1 CCC1=CC(C(=O)N2CC(=O)NC[C@H1]2C(=O)N[C@H1](C)CCN3C=NC=N3)=N[NH1]1 CC1=CC=NC(C(=O)N2CCN(C(=O)C=C3CCSCC3)C[C@H1]2CC(F)(F)F)=N1 O=C(C=1N=COC=1C2CCC2)N3CC[C@](O)(CN4C=C(CN5C=CC=N5)N=N4)C3 O=C(CC1CC2(C1)CN(CC3=CC(F)=CC=C3Br)C2)NCC4=NC=CS4 CC[C@@H1](CC(=O)N[C@@H1]1CC=C(C)CC1)N(C)C(=O)CN2C=CC(C)=N2 CC[C@]1(C(=O)NC2=CC=CC(NC(=O)CCOC3=CC=CC=C3C)=C2)CC1(F)F C=CC1(C(=O)N2CC[C@@H1]2C3CCOCC3)CCN(C(=O)[C@@H1]4COCCO4)CC1 CC=1N=C(Br)OC=1C(=O)NC[C@]2(F)CCCN(C(=O)C(F)=CC3CC3)C2 O=C1C=C[C@@H1](C(=O)N(C2=NC=NC=3[NH1]C=CC2=3)C4CC5(CCNC5)C4)N=N1 CCC(C)(C)NC(=O)[C@@H1](C1=CC(OC)=CC=N1)N2CCC[C@H1]2CN(C)C CNC(=O)[C@H1]1CCN(C(=O)[C@@H1]2CN(C(=O)CN3CCCC3=O)C(C)(C)C2)C1 C[C@H1]1CN(C(=O)C=CBr)CCN(C(=O)[C@@H1](F)OC(F)(F)F)C1 CCOCCC1=NC(C(=O)N2CCC[C@]3(NC(=O)CS(N)(=O)=O)CCC[C@@H1]23)=CO1 COC(=O)CCCC(=O)N[C@H1]1C[C@](C)(NC(=O)C2CC3(C2)CC34CCC4)C1 C[C@@]12CCC[C@H1]1N(C(=O)C3=CC4=NC=CN=C4[NH1]3)CCN(C(=O)C=5C=CON=5)C2 CC[C@H1](C(=O)N1CCCN(C(=O)C2(CN3CCCC3)CC2)CCC1)C(C)(C)CC CNC(=O)NCCC(=O)N1CCC[C@H1](NC(=O)C2=CN=CN=C2C)C1 CCC(C)(C)[C@@H1](O)C(=O)N(C)CCCCN(C)C(=O)C(C)(C)C1=NC=CO1 COC(=O)[C@H1](C)N(C)C(=O)[C@@H1](CNC(=O)CN1[NH1]C=NC1=N)C(C)(C)C CC1=CC(Cl)=C(C(=O)N[C@@H1](C)C[C@H1](C)NC(=O)C2=CC=CC3=C2CCS3(=O)=O)S1 CN(C[C@]12CCC[C@H1]1OCC2)C(=O)C(=O)N[C@H1]3CCOC4(CCSCC4)C3 CCCS(=O)(=O)[C@@H1](C)C(=O)N1CCC2(CC1)C[C@H1]2NC(=O)COCC(=O)NC CC1=NN=C(N[C@H1]2CN(C(=O)C3=CC=CN(C)C3=O)CC2(C)C)S1 NC1=NC=CN2N=CC(C(=O)N3CCO[C@]4(CCCN(C(=O)C=CCO)C4)C3)=C12 O=C(CCN1CCC1)NCC#CC2=CN=C3C=CC=CC3=N2 CC(=O)N1CCC[C@@H1]1C(=O)N[C@@H1]2CN(C(=O)[C@@]3(C(C)C)CCO3)C[C@H1]2C C[C@H1]1[C@@H1](C)[C@@H1]1C(=O)N2CCN(C)C[C@@H1]2CNC(=O)CCC3=CC=CC=C3[N+1](=O)[O-1] CO[C@H1](C(=O)N[C@H1]1C[C@H1]2CC[C@]1(C(=O)NCC3=CN=C(C)C=C3C)C2)C(C)C CCC(C)(C)C1=CN(C[C@@H1](F)C2CN(C(=O)C3=CC4=C([NH1]3)CCCC4=O)C2)N=N1 C[C@@H1](NC(=O)C1[C@H1]2COC[C@H1]12)C3CN(C(=O)CC4=CC=C(Cl)C([N+1](=O)[O-1])=C4)C3 CN(C)C[C@H1](O)CC(=O)N(C)CCN(C)C1=NC=NC(O)=C1Br CS[C@H1](C)C(=O)N1C[C@@H1](CNC(=O)C2=C(Cl)C=CC(O)=C2Cl)C3(CCC3)C1 CN(CC(=O)N1CC[C@@]2(NC(=O)CCC3=NC=C[NH1]3)CCCCC[C@@H1]12)S(C)(=O)=O O=C(NC1(CNC(=O)[C@H1]2CC3=CC=CC=C3O2)CCCC1)[C@H1]4CCCCS4(=O)=O O=C(CCC1CN(C(=O)[C@@]23OCCC[C@H1]2C3(F)F)CCC1)NCC(F)(F)[N+1](=O)[O-1] CCCC[C@@H1](CC)CC(=O)NCCCC1=CN([C@H1](C)C2=CC(F)=CC(Br)=C2)N=N1 COC1=CC=C(CN(CC2=CN=C(C3CCCCC3)S2)C(C)(C)C)C(Br)=C1OC CC1=NC(C)=C(CC(=O)N2CCN(C)[C@@H1](CNC(=O)[C@H1]3CCN(C)S3(=O)=O)C2)S1 CC[C@H1](C)N1N=NN=C1[C@H1](NCCC=2C=C(C)ON=2)C3=CC=C(Cl)C(C)=C3 C=C[C@H1](C)CC(=O)N1CCCN(C(=O)C2=CC=C3C(=C2)NC(=O)CO3)CC1 C=C(CCNC(=O)C1=CN=C(C(C)C)[NH1]1)CNC(=O)C2=CN3N=CC=CC3=N2 COCCN1N=C(C(=O)N[C@H1]2COCC[C@H1]2NC(=O)[C@@H1](CC(C)C)OC)C=CC1=O CCC1(CC)C[C@H1](NC(=O)C=2C=NN(CC)C=2)CN1C(=O)C3=NC=C(Cl)C=C3F CC1(C)C[C@](C)(C(=O)NC[C@H1](C)O)CN1C(=O)C=CCN2CCCC2 C=CCNC(=O)[C@H1](C1=CC=CC=2C=CSC1=2)N3CCCC4=CC=CC=C4CC3 CC#CC[C@H1](NC(=O)[C@H1]1CCC(=O)C1)C(=O)NC[C@H1](COC)C(C)C C=CCC(=O)NCC[C@H1]1CC[C@H1](NC(=O)C=2SC(C)=CC=2Cl)C1 O=C(N[C@@]12CC[C@@H1](C1)N(C(=O)C3CSC3)C2)C4=CC=C(F)C=C4Br O=C(COC[C@H1]1CCCCO1)NCC(F)(F)CN2C=C(CCCCO)N=N2 CC[C@@H1](CC(F)(F)F)C(=O)N1C[C@H1](NC(=O)C=2C=CN(CC#N)N=2)CC[C@H1]1C CC(C)C#CC(=O)N1CC[C@H1](NC(=O)C2CC(C)(O)C2)[C@H1](CO)C1 CC=1C(C(=O)NC[C@@H1](O)CN(C)C(=O)C2=COCCO2)=C[NH1]C3=NC=CC=13 CCCC[C@H1](NC(=O)[C@@]1(N=[N+1]=[N-1])CCN(C(=O)[C@H1]2C[C@@H1]3C[C@@H1]3C2)C1)C(=O)NC COCC[C@@H1]1CN(C(=O)C2=CCCCCC2)CCN1C(=O)[C@@H1]3C(F)(F)C34CCC4 CCCC(C)=CC(=O)NC[C@]12C[C@H1]1CN(C(=O)[C@]3(O)CCOC3)C2 CCNC(=O)[C@H1](C1=NC2=CC=C(OC)C=C2S1)N(C)[C@@H1]3CCN(C(C)C)C3 C[C@@H1](NC(=O)[C@@H1]1CC2(CCO1)CC2)C(=O)NC3(CC4CCC4)CC3 C[C@H1](CC(=O)N[C@@H1]1CC12CC(NC(=O)C3=CC=C4C=NN=C(O)C4=C3)C2)N(C)C CC[S@](=O)CC(=O)N1CCC[C@H1](C2(NC(=O)[C@H1]3CCC[C@H1]3OC)CC2)C1 CC[C@H1](C)CN(CC)[C@@H1](C(=O)N[C@H1](C)C(=O)OC)C1=CC=CC(Br)=C1 CC1=CC=CC=C1OCCC(=O)NC2(CCNC(=O)C=3SC=NC=3C)CCC2 C[C@@H1](C(=O)N1CCN(C)C[C@H1]1CNC(=O)C2=CN(C)C(=O)N(C)C2=O)N3CCC3 CCCC=1ON=C(C)C=1C(=O)N[C@H1]2COC[C@H1]2NC(=O)C[C@H1](CN(C)C)C(F)F CS[C@H1](C(=O)N[C@@H1](C(=O)N1CC[C@H1](C2=CN=CO2)C1)C3(C)CC3)C(C)C CN(CC(=O)N1CCN(C(=O)C=CCF)C[C@@H1](O)C1)C(=O)C(F)(F)C2=CN=CS2 CC(C)[C@@H1](NC(=O)N1CCC2(CCOCC2)C(F)(F)C1)C3=CC=CC=C3 N#CC1=CC=CC([C@@H1](CF)NC(=O)C[C@@H1]2CC[C@H1](C(=O)O)C2)=C1 CC1=NC(CC(=O)N2C[C@@H1](NC(=O)[C@H1](C)OCC(F)(F)F)CC(C)(C)C2)=CS1 CC(C)=C(Br)C(=O)N[C@@H1]1[C@H1]2C[C@H1](NC(=O)C3=C(C)[NH1]C4=NC=CC=C34)C[C@H1]21 CCC1=CC=C(NC(=O)[C@@H1]2CN(C(=O)[C@@]34CCC[C@H1]3C4(F)F)CC2(C)C)C=C1O COCCOCCNC(=O)C(=O)N1CCC([C@H1](C)NC(=O)C2=CSCS2)CC1 CNC(=O)C(C)(C)CNC(=O)[C@@H1]1CC[C@H1](NC(=O)CNC(=O)CN(C)C)C1 CCCSCC(=O)N1CC[C@](O)(CCNC(=O)[C@H1](OCC)C2CC2)C1 CCOCCC(=O)N1CCC[C@](CO)(NC(=O)C2=CC(N)=C(F)C(F)=C2F)C1 COCC[C@@H1](CNC(=O)[C@@H1]1[C@H1]2CCCO[C@H1]21)NC(=O)C=3N=NN(C)C=3C CCC(CC)C(=O)N1C[C@H1]2C[C@H1](N=C3C=C(C)N=C(Cl)[NH1]3)CC[C@H1]2C1 CC[C@@H1](C)C=CC(=O)N1CCC[C@H1](CC(=O)NCC2=NN=C(C)N2C)CC1 CC1=NN2C(C(=O)N3C[C@@H1]4CCOC[C@]4(N5CCOCC5)C3)=C(C)N=C2S1 CCC=1[NH1]N=C(C(=O)NCCCOCCNC(=O)CC2=CC=C(C)S2)C=1Cl C[C@@H1]1CCN(C(=O)[C@@H1]2CCCN3N=CC=C32)C[C@@H1]1CNC(=O)CCC(=O)N(C)C CCOCC1(C(=O)NC[C@H1]2[C@H1](O)[C@H1](O)CN2C(=O)[C@H1](C)C3CCCC3)CC1 C[C@H1]1C(=O)N(C)CCN1C[C@H1]2C[C@@H1](NC(=O)C3=CC=CC4=CC=CC=C34)C2 CO[C@@H1](CC(C)C)C(=O)N[C@H1]1CN(C(=O)C=2C=NN(C3CC3)C=2C)C4(CCC4)C1 COC(=O)C1=CC=C(C)C(CN2CCCOCC2)=C1 C[C@H1]1C[C@H1](C(=O)N[C@H1]2C[C@H1](CCNC(=O)CNS(=O)(=O)C=3C=NN(C)C=3)C2)CO1 CCC=1C=C(C(=O)N2CCO[C@@H1](CNCC3=C(Cl)C=CC(F)=C3Cl)C2)N(C)N=1 CCCCN1CCOC[C@@H1]1C(=O)N[C@H1]2C[C@@H1](NC(=O)CCC=3C(C)=NOC=3Cl)C2 C=CCO[C@H1](C)C(=O)N[C@@H1](C)CCCCNC(=O)C1=CC=C(C)C(Cl)=C1F C=CCCC(C)(C)NC(=O)[C@H1]1CCO[C@@H1]1CNC(=O)C2=NOC=C2Cl C#CCOC1=CC=CC(C(=O)N[C@H1](C)CN(C)C(=O)CCCN2C=CN=N2)=C1 CN(C)C[C@@H1](O)CC(=O)N1CC=C[C@H1](NC(=O)C=C2CCN(C)C2)C1 CNS(=O)(=O)CC(=O)N[C@@H1](CC(=O)N[C@@H1]1CCCSC1)C(F)F O=C(N[C@H1]1CC[C@@H1](NC(=O)[C@H1]2CCCN2C(=O)C=CCF)CC1)[C@@H1]3CCC[C@@H1]3O C#CC[C@@H1](C(=O)NC12CC(NC(=O)C3=C[C@]4(CCOC4)C3)(C1)C2)C5CC5 C=C[C@@H1](O)C(=O)N1C[C@@H1]2C(CNC(=O)C3=CSC(C(C)C)=N3)[C@H1]2C1 C[C@@H1](NC(=O)C1CCC(C)(C)CC1)[C@@H1]2C[C@H1]2C(=O)N(C)CCC3=CN=CC=N3 CC1(C)C[C@H1](NC(=O)CN(C(=O)[C@@H1]2C[C@@H1]2Cl)C3CC3)C(=O)O1 CC1(C)C[C@H1](NC(=O)C[C@@H1](O)C2=CC=C(F)C=C2)CN(C(=O)CSCCC#N)C1 CC1CC(CC(=O)N[C@H1]2COC3(C2)CN(C(=O)C(=O)C4CCCC4)C3)C1 O=C(CC=1C=CSC=1Br)NCCCCNC(=O)C2=CC=C(O)C=C2F CN(C)[C@H1](CCO)C(=O)N1CC(C)(C)C[C@@H1]1CNC(=O)C=2SC=CC=2Cl C=CCN(CCC(=O)NC1CCN(OCC)CC1)C(=O)[C@@]23CCC[C@@H1](CO2)C3 O=C(NCC1=CC=C2C(=C1)CC[C@H1]2NC(=O)[C@H1]3CCCCS3(=O)=O)C4=CN=NS4 CC[C@H1](CNC1=CC=C(S(=O)(=O)NC[C@@H1]2CCC(C)(C)O2)C(Cl)=C1)N(C)C CC(C)C=1C=COC=1C(=O)N2CC[C@H1](C3=CN([C@H1]4CCC5=CC=CN=C54)N=N3)C2 CC(C)[C@@H1](C)C(=O)NC(C)(C)[C@H1](C)NC(=O)CCP(C)(C)=O CC1=CSC2=NC(CC(=O)NCC[C@H1](C)CCNC(=O)CC3CN(C)C3)=CN12 CC[C@H1](O)C(F)(F)C(=O)NC1CC2(CC(CNC(=O)C[C@H1](C)OC)C2)C1 COCCC1CCN(C(=O)C[C@@H1](O)CNC(=O)[C@H1]2C[C@H1](SC)C2)CC1 CC(C)[C@H1](CNC(=O)[C@H1](C)C1CCC1)NC2=NC=NC(Cl)=C2C#N COC(=O)[C@@H1](CO)NC(=O)[C@H1]1C[C@@H1](C)CN(C(=O)C2=CC=CC(O)=C2)C1 CC=C1C[C@@H1](C(=O)NC2(C3CCN(C(=O)[C@H1]4CCN(C5CC5)C4=O)CC3)CC2)CC1 COC1=CC=C(NC(=O)[C@@H1]2CCCC[C@@H1]2C(=O)N3C[C@H1]4[C@H1](C3)C4(F)F)C=C1 CSCC[C@H1](O)C(=O)N1C[C@H1](C2CC2)[C@@H1](NC(=O)C3=CC=C(C(F)F)C(F)=C3)C1 NC(=O)C1=CC(C(=O)N2CC3CC2(C(=O)N[C@H1]4CC5(CCC5)[C@H1]4O)C3)=C[NH1]1 CC(C)N1C=NC(C(=O)N2CC=C(CC(=O)NCC=3C=N[NH1]C=3)CC2)=C1 CNC(=O)COCC(=O)NC[C@]1(F)CC[C@H1](CNC(=O)CSCCOC)CC1 O=C(N[C@H1]1C[C@H1](CNC(=O)[C@H1]2C[C@@H1]2C(F)(F)F)C1)C3=C(Cl)C=NC=C3Cl CC1=CC=CC=C1OCCCNCCNC(=O)C2=C(Cl)C=CC=C2Cl C(=O)NCC(=O)N1CCOC[C@@H1]1C2=CC=C(C(=O)NCC=3OC=NC=3C)N2C CC(C)[C@H1](C)CC(=O)N[C@]1(CNC(=O)[C@]2(CO)CCCCO2)CC3CCC1CC3 COC(=O)NC1=CC=CC(C(=O)NC[C@H1]2CCN2C(=O)[C@@]34CC[C@@](C)(C3)OC4)=C1 CCC1=CC(C(=O)N[C@@]2(CF)CCN(C(=O)CNC(=O)C=3C=COC=3)C2)=NO1 C[C@H1](O)[C@H1](C)C(=O)N1CC2CC1(C3=CC=C(Br)C=C3)C2 C=C[C@H1]1CN(C(=O)[C@@H1](CCC)OC)C[C@H1]1NC(=O)C2=CC(O)=NC(OC(C)C)=N2 CC1(C)C[C@H1](NC(=O)[C@@H1]2C[C@H1]3C[C@H1]2[C@H1]4[C@@H1]3C4(F)F)CN(C(=O)CC=5C=C[NH1]N=5)C1 C=C(Cl)CN=C1N=C(N2CC[C@@H1](C3CCC4(CC3)OCCO4)C2)C5=C([NH1]1)CCS5 CC(C)C1=NN=C(N(CCNC(=O)C2=CN(C=3C=NN(C)C=3)C=N2)C4CC4)O1 CCOC[C@@H1](C)C(=O)N1CCC[C@@](CO)(NC(=O)CCCN2N=C(C)N=C2C)C1 C[C@@H1](CNC(=O)[C@@H1]1C[C@H1]1CF)CN(C)C(=O)[C@H1](C)N2CSCCSC2 CC(C)C=1C=CSC=1C(=O)N[C@@H1]2CC[C@H1]2CNC(=O)[C@H1](C)O[C@@H1]3CCOC3 CP(C)(=O)CNC(=O)[C@H1]1C=CCN1C(=O)[C@H1]2CC3=CC=CC=C32 O=C1CN(C(=O)C[C@@H1]2CC[C@@H1]3C[C@H1]23)C4=CC=CC=C4N1CC5CC5 C=CC[C@@H1](CNC(=O)CN1N=NC2=CC=CC=C2C1=O)NC(=O)C=3C=COC=3 CCC[C@H1](CC(C)C)C(=O)N[C@H1]1CCCN(CCC=2C=NN(C)C=2)CC1 CCCCC(=O)N[C@@H1]1CN(C(=O)[C@@H1]2CCCC[C@@H1]2C3=CC=CC=C3)CC[C@H1]1F C#CCCN(CCOC)C(=O)[C@]12C[C@H1]1CCN2C(=O)CNC(=O)CC C[C@H1]1CC[C@H1]1C(=O)NCCCNC(=O)C2=CC=C(S(N)(=O)=O)C=N2 CCC1=CC(C(=O)N2CCC3(CC2)C[C@@H1]3NC(=O)C4=N[NH1]C5=C4C[C@@H1](C)C5)=N[NH1]1 COC[C@@H1](C)C(=O)NCC1=CN(CCNC(=O)[C@H1](C)SC)N=N1 CCSCC1=CC=CC=C1C(=O)N2[C@H1]3CC[C@@H1]2C[C@H1]3NC(=O)C4=CSC=C4C CC1=NC=NC(C)=C1C(=O)N2CC3(CCN3C(=O)[C@]4(C)COCCO4)C2 CC1=CC=CC=C1OCCN2CCC[C@H1]2[C@H1]3CCCCN3C(=O)C4(C(C)C)CC4 CCOC1=CC=C(C(=O)NC[C@H1]2C[C@H1](F)CN2C(=O)CCC3(C#N)CCC3)C=C1 CCCC[C@H1](C)C(=O)N1CC(CC(=O)N2CC[C@H1](C)O[C@H1](C)C2)(OC)C1 O=C(N[C@@H1]1CC[C@@H1]2CN(CC3=CC(C(F)(F)F)=CC=C3Cl)C[C@H1]21)C4CCCCC4 C[C@@H1](CCC1CC1)NC(=O)C=2C=C(CNC(=O)C3CCC3)ON=2 C[C@@H1](CN(C)C(=O)[C@@]12CC[C@@H1](C1)S(=O)(=O)CC2)N(C)C(=O)CC3=NN(C)C=C3Cl CCCC(C)=CC(=O)NC[C@@H1]1C[C@H1](C(F)(F)F)CN1C(=O)C2=CC=CC=C2 CC[C@H1](C)[C@@H1](C)N(C(=O)[C@@H1](C)N1C=C(CN2CCC(C)CC2)N=N1)C3CC3 C[C@@H1]1CCN(C(=O)OC(C)(C)C)C[C@H1]1NC(=O)C=CC=2C=N[NH1]C=2 CN(CC1CC1)C(=O)[C@H1]2CC3(CC3)CN2C(=O)[C@H1]4C[C@@H1]4[N+1](=O)[O-1] C#C[C@H1](C)NC(=O)[C@](C)(CO)NC(=O)[C@H1](C)OC1CCCC1 COC(=O)C1(NC2CCN(C(=O)C34CC(C5CCNCC5)(C3)C4)CC2)CCC1 O=C(NC[C@H1]1C[C@H1]2CC[C@H1]1N(C(=O)C=CC3=CC=CC=C3)C2)C4=CC=NC(O)=C4 CCCC1=CC(C(=O)N2CCC[C@]2(C)CNC(=O)C[C@@H1](C)C(F)(F)F)=NN1C C#CC1=CN(C)N=C1C(=O)N[C@H1]2CC[C@H1](C)N(C(=O)C3=CN(C(C)C)C=N3)C2 CCC1=CC(C)=C(C(=O)NCC(C)=CC(=O)NCCN2C(=O)CCC2=O)O1 CC1=NC2=C(O1)CCC[C@@H1]2CC(=O)N3CCC[C@](C)(NC(=O)C4=CC=NC=N4)C3 COC1=CC(C)=C(C(=O)N(C)CCNC(=O)[C@H1]2CCCC[C@@H1]2N3C=CC=C3)C=N1 CN1N=C(C(=O)N[C@@H1]2[C@@H1]3CC[C@H1]2N(C(=O)C4=CN=C(O)O4)C3)C=C1[C@@H1]5CCCO5 O=C(C1=CC=C2C(=C1)COC2)N3CCC[C@@H1](C4CN(C(=O)[C@H1]5CC56CC6)C4)C3 COC(=O)[C@H1]1CC[C@H1](C(=O)N2CCCC[C@@H1]2CNCC3=CC=C(Br)C(O)=C3)CC1 CO[C@@H1]1C[C@H1]1C(=O)N2CCN(C(=O)C3=CC=C(S(N)(=O)=O)C=C3F)C[C@@](C)(F)C2 CC[C@@H1](CNC(=O)CCC1CC(F)(F)C1)NC(=O)C2=NC=CC=C2O CC1=NC(C)=C([C@@H1](C)N(C=O)CC2=CC=C3NC=CC3=C2)S1 CC(C)(C)[C@@H1](CC1=CC=C(Cl)C=C1Cl)NS(=O)(=O)N2CCOC[C@H1]2C#N C#CCCCCCCCNC(=O)C[C@H1]1C[C@H1](C)N(C(=O)C=CC=2C=COC=2)C1 CCC=1SC(C(=O)N2CC[C@@](CCOC)(NC(=O)C=CC3CC3)C2)=CC=1C CC[C@@H1]1C[C@H1]1C(=O)NC[C@H1]2CCN2C(=O)C3=CC=CN(C)C3=O CC(=CC(=O)NC1[C@H1]2C[C@H1]1CN(C(=O)CN3CCS(=O)CC3)C2)C=4C=NN(C)C=4 C=CCC(=O)N[C@H1](CNC(=O)C[C@@H1]1CCN(C2COC2)C1)C3=CC=CC(Cl)=C3 CC(C)(C=CC(=O)N[C@H1]1CCCN(C(N)=O)C1)C(=O)O O=C([C@H1]1CCN2N=CC=C2C13CC3)N4CC5=C(C4)CNC5 CC1=C[NH1]C=C1C(=O)N2C[C@H1]3C[C@@]3(C(=O)N4CCC(C(C)(C)O)CC4)C2 CCCC[C@H1](CC(=O)N[C@H1]1CCCC2(C1)N=N2)NC(=O)[C@@H1](F)N3C=CN=C3 O=C(C1=CC=CC=2ON=CC1=2)N3C[C@@H1]4CCN(C(=O)[C@H1]5CC6=NN=CN6C5)[C@@H1]4C3 O=C1CCC(C(=O)N2CC3CC2(CNC(=O)[C@@H1](O)CC4=CN=C[NH1]4)C3)=NN1 CC[C@]1(C)CC[C@H1](C(=O)N(C)C[C@@H1]2CCCN2C(=O)C=3C=CSN=3)O1 CC=C(CC)C(=O)N(CC)CCNC(=O)CN1CC[C@H1](CO)C1 CC(=CC(=O)N1CC[C@@H1]([C@H1](C)NC(=O)CCC=2C(C)=N[NH1]C=2C)C1)C(F)F CC1=CC=C([C@H1](C)N(C)C(=O)[C@@H1]2CN(CC3=CC=NC(C)=C3)CCO2)C=C1 CC/C(C)=C/C(=O)NC1(C)CCN(C(=O)C=2C=CC3=CN=CN3C=2C)CC1 COCC1=CC=CC(CN=C2C=C(NCCCCCO)N=C(C(F)(F)F)[NH1]2)=C1 CC(C)(C)[C@@H1](CNC(=O)C1=COC2=C1CSC2)NC(=O)CSCC3=CSC(=N)[NH1]3 CSC1=NC=CN=C1C(=O)N2CC(C)(NC(=O)[C@H1](C)N3CCC3)C2 CSC[C@H1](O)C(=O)N[C@@H1](CNC(=O)C1=C(C)N=CN1CC(=O)OC)C(C)C CCC[C@H1](NC(=O)[C@H1](CN(C)C)N(C)C)[C@H1](O)C(=O)NCCN1CCO[C@H1](C)C1 C[C@@H1](O)C(F)(F)C(=O)NC[C@@H1]1C[C@@H1]2CCC[C@@H1]2N1C(=O)C3=CN=C(S)N3C4CC4 CC=1N=C(C(=O)N2CCN(CC3(NC(=O)[C@H1]4CCCS[C@H1]4C)CC3)CC2)N(C)N=1 CN(C)C1=CC=C(C(=O)NC[C@H1](O)CCNC(=O)[C@]23CCC[C@H1]2CC(=O)C3)C=N1 CC[C@@](C)(CO)C(=O)N[C@H1](CO)[C@H1](C)NC(=O)C=1C=CN(C2=CC=CC=C2)N=1 CCC(CC)(CCNC(=O)C1=CC=CC(NC)=N1)NC(=O)CC=2N=C(C)SC=2C CC1=CN2C=C(C(=O)N[C@H1]3C[C@H1](NC(=O)[C@]4(CO)CC4(F)F)C3)SC2=N1 CC1=CC=CN=C1CC(=O)NC[C@@]23C[C@@H1]2CN(C(=O)C=4C=NN5C=4OCC5)C3 CC(C)CO[C@@H1](C)C(=O)N[C@]1(C)C[C@@H1](NC(=O)CO[C@H1]2CCOC2)C1 CN(CC1CCCCCC1)C(=O)C2=CC(CNC(=O)[C@H1]3CCS3(=O)=O)=CC=N2 CN1C=CN=C1SCC(=O)N[C@H1]2C[C@H1]3CC[C@H1]2CN3C(=O)CC4(C)OCCO4 CCC[C@H1](O)CC(=O)N1CC[C@](CF)(NC(=O)C2=CC=NC(SCC)=C2)C1 CCC1=CC=CC(C(=O)N[C@@]23C[C@@H1]2CN(C(=O)C(CC(C)C)CC(C)C)C3)=C1F CCC(C)(C)[C@H1](C)CC(=O)N[C@H1](C)CNC(=O)C1=CC=C(OCCC(C)C)C=C1 NS(=O)(=O)C1=CC(C(=O)N2CC(CO)(NC(=O)C3=CC(Cl)=NS3)C2)=CC([N+1](=O)[O-1])=C1 CC(C)(C(=O)N1CC[C@@H1]1CNC(=O)C2=CC(F)=C(F)C=C2Cl)C3=CC=CN=C3 CC[C@]1(C(=O)N(C)CC2=CC=NC=C2F)CCN(C(=O)C3=CCCCO3)C1 COCCCCC(=O)N1CC[C@H1](NC(=O)C2CCN(OC)CC2)CC(C)(C)C1 CC[C@@H1]1CC[C@@H1]1NC(=O)C2=CCC(N)(C2)CCC CN(C[C@@H1]1CCCN(C(=O)[C@H1](F)C(C)(F)F)C1)C(=O)[C@]2(C#N)CC2(C)C CC(C)CC(=O)NCCC(=O)N1CC[C@H1](N(C)C(=O)[C@]23C[C@H1]2CNC3=O)C1 CC(C)CNC(=O)CCNC(=O)CCOC1CN(C(=O)[C@H1](C)C2=CN=CN=C2)C1 CN1C[C@@H1](C(=O)N2CC[C@@]3(CCN(C(=O)[C@H1]4CCCC(F)(F)C4)C3)C2)NC1=O NC(=O)C[C@@H1](O)C(=O)NC[C@]1(F)C[C@@H1](CNC(=O)CC2=CC(O)=CC=C2Br)C1 C=CCCN=C(NCC1=CC=CN=N1)N2CC[C@H1](C)[C@H1](C)C2 CCCN1CCC[C@H1](C(=O)NCC#CCNC(=O)C2=CC=CN=C2C)C1 CC[C@@H1]1C[C@@H1](C2=NC(C)=NN2C3=CC=CC=C3OC)CCO1 CCC(C)(C)CCNC(=O)[C@@H1]1CN(C2=NC=NC=3SC(C)=C(C)C2=3)CC[C@@H1]1O CC=1[NH1]C(C(=O)NC2=CC=C3C=COC3=C2)=C(C)C=1C(=O)NCC=4C=COC=4 NC(=O)CC[C@H1](C(=O)NCC1=CC=CC2=C1OCCC2)N3C=C(CSCCO)N=N3 C#CC1(NC(=O)[C@H1](F)CC2CN(C(=O)[C@@]3(C)C[C@H1]4C=C[C@H1]3C4)C2)CC(F)(F)C1 O=C1C[C@H1](C(=O)NCC2(C(=O)NC3=CC=C(F)C(C(F)F)=C3)CCC2)C4(CC4)C1 CNC(=O)CCC(=O)N[C@@H1]1CCN(C(=O)CCCC2=CC=C(F)C=C2)C1(C)C COCCC(C)(C)CC(=O)N[C@H1]1[C@H1]2C[C@@H1]3[C@H1]1[C@@H1]3[C@@H1]2C(=O)NCC#CC#CCO CCO[C@@H1]1CN(C(=O)CNC(=O)C(F)(F)F)C[C@H1]1CNC(=O)COC=2C=CSN=2 CC1(C)CC[C@H1](NC(=O)[C@@H1](NC(=O)CN=C2C=C[NH1]C=C2)[C@H1]3CCOC3)C1 CCN1N=C(C(C)C)C=C1C(=O)N(CCO)CCCNC(=O)[C@@H1](C)CF CCNC(=O)[C@H1](C1=CC=C([N+1](=O)[O-1])C=C1Br)N2CC[C@H1](O)C[C@@H1](C)C2 O=C(N[C@@]12CC[C@@H1](C1)N(C(=O)C3=CC=C[NH1]3)C2)C4=CC=C5C=CC(Cl)=CC5=N4 COC(=O)[C@@H1]1CC[C@H1]1C(=O)N2CC[C@H1](NC(=O)[C@H1]3CC4(CO3)CC(F)(F)C4)[C@H1]2C CC1=NN(C(C)C)C(N2CC(CCCCNC(=O)[C@@H1](C)CC(N)=O)C2)=C1[N+1](=O)[O-1] C[C@H1](C(=O)NC1CC(CNC(=O)C2=CN=C3C(=N2)CCCC3)C1)[C@@H1](C)O C[C@](O)(CC(F)(F)F)C(=O)NCC[C@@H1]1CCN(C(=O)CC2CSC2)C1 CC(C)C1=CC=C(CC(=O)N(C)C[C@H1](O)CN(C)CC2CCOCC2)C=C1 C#CC1=CN(C)N=C1C(=O)NC2(C/C=C/C(=O)N[C@H1](C)CCOC)CCC2 COC1CN(C(=O)C[C@@H1](NC(=O)[C@H1]2CCCSC2)C(C)(C)C)C1 CO[C@@H1]1CCCN(C2=NN=C(CC3CCCC3)N2CCNC(=O)OC(C)(C)C)C1 CCCC1(CNC(=O)C[C@@H1](CNC(=O)C2=CN=CN=C2C)C3CCC3)CCC1 CCOCC(=O)NC[C@@]1(C2CC2)CCN(C(=O)C3=CC4=C(Cl)C=CN=C4S3)C1 CN1N=CC=C1[C@@H1](O)C(=O)NC[C@]2(F)C[C@H1](NC(=O)C3=CC(C(N)=O)=NO3)C2 CCCC1=NN=C(S)N1CC(=O)N2C[C@@H1]3C[C@@H1]4[C@@H1](CCN4C(=O)CNC=O)[C@H1]3C2 CC1=CC=C([C@H1](C)C(=O)NC[C@H1]2C[C@@H1]3CC[C@H1](C2)N3C(=O)C4=CC=C(C)[NH1]4)S1 C=C(C)CCCC(=O)NCCNC(=O)[C@@]1(C2=CC=C(OC)C=C2)CC1(F)F CC(=O)N[C@@H1](CCC(N)=O)C(=O)N[C@H1](C)CCCNC(=O)C1(S(N)(=O)=O)CC1 C1C=CC=C1CC(=O)N2CC[C@@H1](C(C)(C)NC(=O)CC3(C)CC3)C2S CC=1C=CC2=NON=C2C=1C(=O)NC[C@@H1](C)N(C)C(=O)C3=CC=C(CO)O3 CC=1N=CN(C)C=1C(=O)N2CC[C@@H1](C)[C@H1](CNC(=O)C=3C(C)=NN(C)C=3Cl)C2 CO[C@]1(C(=O)NCC2=C[NH1]N=C2C(=O)N[C@@H1]3C[C@@H1]3F)CCSC1 CCC[C@@H1](C)[C@@H1]1CCCN1C(=O)CCOC2CN(C(=O)C3=CN=C(O)O3)C2 CC1=CN=C(CC(=O)N2CCCN(C(=O)C3=CC=C(O)C=C3F)C[C@@H1]2C)S1 O=C1CN(C(=O)N[C@@H1]2CCS(=O)(=O)C3=CC=CC=C32)[C@H1]4COCCN14 CC12CC(CC(=O)N3CC4(C3)SCC[C@H1]4NC(=O)CCCN5C=NC=N5)(CO1)C2 CC[C@@H1]1C[C@H1](C(=O)NCC[C@H1]2C[C@@H1]2C)CCN1C(=O)[C@H1](C)OC O=C(NC[C@@H1]1CCN(C2=CC=NC=N2)C[C@@H1]1O)C=3C=C[NH1]N=3 CN(CC(=O)NC[C@@H1]1CN(C(=O)C2=CC=C3N=CC=CC3=N2)[C@H1]4C[C@H1]41)C5CCC5 CCC[C@@](C)(O)CC(=O)NC[C@@H1](C(=O)NC1=CN=C(COC)N=C1)C(C)C COC(=O)C1=NC=C(N2C[C@H1](C)[C@H1](NC(=O)[C@H1](C)OC3CCCCC3)C2)N=C1C COC(=O)C1=C(C(=O)N2CCN(C)[C@H1]3CCCC[C@@H1]32)S4C=C1[C@@H1](C)CC4(C)C CSC[C@@H1](C)C(=O)NC[C@H1]1CN(C)CCN1C(=O)C=2C=CN(C3=CC=CC=C3)N=2 CN(C)CCC1(C(=O)N[C@@H1](CNC(=O)CSC(F)F)C2=CC=CC(Cl)=C2)CC1 CC(C)(C)C[C@@H1](CO)NC(=O)C1=CC2=CC=NC=C2C(O)=N1 CC=1C=CSC=1CN(C)C2=NC=CC(N3CC[C@@H1](OCCO)C3)=N2 COC1=CC=C(Cl)C2=C1CCN([C@H1]3CCCN(C4=CC=C(Br)C=C4)C3=O)C2 CC1=CC=C(NC(=O)[C@]2(C)C[C@H1](O)CN2C(=O)[C@H1]3C(C)(C)C3(F)F)C(C)=N1 CN1C=CC(CNC(=O)N[C@H1]2CCCN(C3=CC=CC(F)=C3)C2)=C1 COC(=O)[C@]1(C)CC[C@H1](C(=O)N[C@H1](C)CN2CCCCC2)CC1 CC1=C(Cl)C(C(=O)N[C@]23CCN(C(=O)C4=NC=C(Cl)C=C4Cl)C[C@@H1]2C3)=NN1C CC1=CC=C(C(=O)N[C@]23CCC[C@H1]2N(C(=O)C4=NC(=O)N(C)[NH1]4)CCC3)N=C1 CCCCC(=O)N1C[C@@H1](NC(=O)C2=CC=C3C(=N2)CCC3)[C@H1](C(F)(F)F)C1 C[C@@H1]1CN(C(=O)C=CC2=CC=C(Cl)N=C2)C[C@@H1]1CNC(=O)C3(C#N)CCSCC3 CS(=O)(=O)CC[C@@H1]1CN(CC2=CC=NN2C3CCCCC3)CCO1 CCN(CCNC(=O)C1=CC(C(N)=O)=CC([N+1](=O)[O-1])=C1)C(=O)[C@H1]2CCCC2(C)C CCC[C@H1](C)NC(=O)C1(NC(=O)[C@H1]2C[C@@](C)(O)C2)CSC1 CC(C)(C(=O)N1CC[C@@H1](OC2=CC=CC=N2)C1)C3=CC=C(Br)C=C3F CC1=NC(C2=CC(Br)=C(C)S2)=CC=C1C(=O)NC=3OC=NC=3C#N CN(C(=O)C1=C(Cl)CC1)[C@@H1]2CCN(C(=O)[C@@H1](O)COCC3=CC=CC=C3)C2 CN(C)[C@@H1]1CC[C@H1](N=C2[NH1]C(N3CCC=4SC(Cl)=CC=4C3)=NC5=C2CCC5)C1 C=CC=CCC(=O)NCC[C@H1]1COCCN1C(=O)[C@@H1]2CCCCN(C)C2=O CC1=CC=C([C@@H1](CNC(=O)[C@H1]2CCOC3=CC=CC=C32)NC(=O)C4(C)CCC4)S1 O=C(C=CSC1=CC=CC=C1)N[C@H1]2CCC[C@H1]2NC(=O)C[C@@H1](C(F)(F)F)C3CC3 CN(C)[C@@H1](C(=O)NC[C@]1(C)CCCN1C(=O)[C@@H1]2C[C@H1]2C(F)(F)F)C(C)(C)C CCN(C(=O)[C@H1](C)N1CCN(C(=O)CCCC(C)(C)C)CC1)C2CCCCCC2 O=C(NC[C@H1]1C[C@](F)(CNC(=O)C=2C=COC=2C3CC3)C1)C4=C[NH1]C=CC4=O CC1=CC=C(C(=O)N[C@H1]2C[C@@H1](CNC(=O)C3=NC=C(Cl)C=C3F)C2)N1C CCC1=C[NH1]N=C1C(=O)N(C)C2CCN(C(=O)C3=CCS(=O)(=O)C3)CC2 CCC=1SC=NC=1C(=O)N2CC[C@@](C)(CNC3=NC=C(C(C)(C)O)C=N3)C2 CC1=NN(C)N=C1CNC(=O)CC23CC(C2)C3 CN(CC(CO)(CO)NC(=O)C1=CSC(Cl)=C1)C(=O)C2=CC=C3OC(=N)[NH1]C3=C2 CNC(=O)[C@@H1](CC(C)C)NC(=O)N(C)[C@@H1](C)C(=O)OC CNC(=O)CCC(=O)NC[C@H1]1C[C@@](F)(CNC(=O)[C@H1]2COCC[C@@H1]2C)C1 CCS(=O)(=O)N1CC(C(=O)N2CC(CCNC(=O)[C@H1](F)C(F)(F)F)C2)C1 COCCN(C)CCNC(=O)C=1[NH1]C=CC=1CNC(=O)C2=CC(Cl)=CN2C CC(C)(CCCCNC(=O)COC1CCOCC1)C(=O)NNC(=O)CC2(O)CC2 CCCN(CCNC(=O)C(F)(F)CC1CC1)C(=O)[C@@H1]2C[C@@H1]3C[C@@H1]3C2 C=CC[C@H1](CNC(=O)CCOCC1=CC=CC=C1)NC(=O)[C@]2(C)CCN(C)C2=O COC[C@]1(C)CCCN(C(=O)[C@@H1](CN2C=NC=N2)NC(=O)CN3N=CN=N3)C1 CC1=NN=C(CCC(=O)N[C@H1]2CN(C(=O)C3=CC=C4OC=NC4=N3)C[C@H1]2C)N1C CC[C@H1](C)[C@@H1](CC(=O)N1CC[C@H1]2CCN(C)C[C@@H1]21)NC(=O)[C@@]3(C)CC(C)=NO3 CC(C)(C#N)CC(=O)N1C[C@H1]2N(C(=O)CCC3CCCC3)CC[C@@]2(C)C1 CC1=CC=C(C(F)(F)C(=O)N[C@@H1](C)CNC(=O)CC2=CC(C)=CC=C2F)C=C1 CC1=CC(Br)=C(NC(=O)C2=CC=C3N=CC(C4=CC=C5C(=C4)CC5)=CC3=C2)C=N1 CC1=CC=NC([C@H1](C)NC(=O)/C=C/C(C)(C)NC(=O)CC(C)(C)O)=N1 CC(C)(C)OCC(C)(C)C(=O)NC[C@H1]1[C@@H1]2CN(C(=O)CC[C@H1]3CCCCO3)C[C@H1]12 CCCN(C(=O)COCCOC)C1CCN(C(=O)C2=C(OCC)CCC2)CC1 CC(C)C[C@@H1](NC(=O)C=CC1=CC=C(F)C(F)=C1)C(=O)OC(C)C CC[C@@]1(NC(=O)[C@H1](O)C2CCCC2)CCCN(C(=O)CC3=CN(C)N=N3)C1 CN(C(=O)CC1=CN=CN=C1)[C@@H1]2CN(C(=O)[C@H1]3C[C@@H1](O)C3)CC[C@@H1]2O CCC=1C=C(C(=O)N2CC[C@H1](CCNC(=O)C[C@H1]3CCN(C)C3)C2)N(C)N=1 CC1(C)C[C@H1]1[C@H1](NCCN2C=C3N=CC=CC3=N2)C(F)F CC1(C)CO[C@H1](C(=O)N[C@H1]2CCC[C@@H1]2CNC(=O)CCC3=CN=C4N3CCOC4)C1 CCN(C[C@H1](C)NC(=O)C1(C(N)=O)CC1)C(=O)CN(C)C2=CC=CC=C2[N+1](=O)[O-1] CCO[C@@H1](C)C1=NC(C)=C(C(=O)N(C)CCCNC(=O)CCCOC(C)=O)S1 CON1C[C@H1](C(=O)NCC2CN(C(=O)CN3N=NC(C)=N3)C2)CC1=O CC(=O)OCC1=CC=C(CN2CCN(C(=O)C3=CC=CC=C3CO)C[C@H1](O)C2)O1 C[C@@H1](C(=O)N1CC[C@H1]2[C@@H1]1CCN2C(=O)C3=CC(Cl)=CN=C3O)C4=CC=CC=C4 O=CNC1CC2(C1)CC(C(=O)N3CCC4=CC=CC(O)=C43)C2 CO[C@H1](C)CCC(=O)NC[C@@]12C[C@@H1](CO1)N(C(=O)C3SCCS3)C2 O=C(NC1=CC=C(O)C(F)=C1)[C@@H1]2CN(C(=O)CN3CCOC3=O)CCN2 C#CCN(C(=O)[C@@H1](CC1CCCC1)OC)[C@H1]2CCN(C(=O)C34CCC(C3)C4)C2 CCOC(=O)[C@](C)(CC)NC(=O)C=1C=CSN=1 C[C@@H1](CNC(=O)C/C=C/C(C)(C)C)C(=O)NC1(CO)CCCCCC1 C#CC1(C(=O)NC2[C@H1]3CCCCC[C@H1]23)CN(C(=O)C4=COC(C)=C4)C1 C1=CC=C(N[C@@H1]2CCN(C3=CC=NC=C3)C2)C=C1Cl CC[C@H1](C)C[C@H1](NC(=O)C=1SC(O)=NC=1C)C(=O)N[C@@H1](C)CC2=CC=NC=C2 CC1=CN=NC(O)=C1C(=O)NC[C@H1](C)CNC(=O)[C@@H1]2CC(=O)N(C=3C=N[NH1]C=3)C2 CC1=CC=NC(C(=O)N2CC3(CCCN3C(=O)C4=CC=NC=C4F)C2)=C1 COCCN1N=NN=C1[C@H1](N[C@H1](C)C=2SC=NC=2C)C3=NC=CN3C(C)C C[C@H1](C1=CC=CC=C1)N(C(=O)CC#N)C(=O)C2=CC=C3C(=C2Cl)OC(F)(F)O3 C[C@H1]1CCN(C(=O)C=2[NH1]N=CC=2C#N)[C@H1]1CNC(=O)CCC3=CSC4=CC=CC=C34 O=C(NCC[C@H1]1CCCCO1)[C@@H1]2CN(C(=O)C3=CC=C(F)C=N3)C[C@H1]2F CCOC(=O)[C@H1]1[C@H1]2C=C(CN(C(=O)C=3C=C([C@H1]4CCOC4)[NH1]N=3)C2)N1 CON(CCNC(=O)NC1=CC2=C(C=C1C)OCO2)CCC3CC3 CCOC=CC(=O)N(C)C[C@@H1](CC)NC(=O)C1=CC=CC(C(N)=O)=C1N CN(CCN(C)C(=O)C1=C[NH1]C2=CC=CC=C2C1=O)C(=O)CC[C@H1]3CCOC3 CC1=CC(C)=CC(OCC(=O)N[C@H1]2C[C@H1](CNC(=O)[C@@H1]3C[C@]3(C)C(C)C)C2)=C1 C[C@@H1](CNC(=O)[C@@H1]1CC=CCO1)NC(=O)C2=CC=C(C(F)F)O2 CCC[C@H1](CCO)CNS(=O)(=O)C1=CC=C(N[C@H1]2C[C@@H1](N3CCCC3)C2)C=C1Cl C[C@@H1](OCCN(C)C)C(=O)N[C@H1]1CC[C@@H1](NC(=O)[C@H1](C)C2=CC=CN=C2)CC1 C=CCNC(=O)[C@@H1]1CCCN1C(=O)[C@]2(C)CCCN2C(=O)C3=CC(Br)=NC(Br)=C3 C=C[C@@](C)(O)CC(=O)N(C)C[C@H1](C)N(C)C(=O)[C@H1]1C[C@@H1](OC(F)F)C1 C[C@H1](CN(C)C(=O)/C=C/CN(C)C(=O)[C@@H1]1CC=CCO1)C(F)(F)F C[C@@H1]1CN(C(=O)[C@@H1]2CNC(=O)CC23CCC3)C[C@H1]1CNC(=O)[C@H1]4CCCN4C=O C=C(C)[C@H1](CC(=O)N1C[C@H1]2CC[C@@](NC(=O)CC3=CN=CN3C)(C2)C1)OCC C=CCC1(NC(=O)C2=CN=CN=C2)CCN(C(=O)C=3N=C(O)SC=3C)CC1 CC=1C=CN2C=NC(C(=O)NCCCNC(=O)CC3(C#N)CCCCC3)=C2C=1 C=CC1(C(=O)NC[C@H1](O)CN(C)C(=O)CN2CCCCS2(=O)=O)CCCCC1 CCN(CCCNC(=O)CCCCCCC)C(=O)C1=CC=C(OC)N=C1C CN1C(=O)CC[C@H1]1CC(=O)N2CC[C@@H1](CCNC(=O)C3(O)CCC3)C2 C[C@@H1]1C[C@@H1](NC(=O)C2=CC=CC3=C2N=C(O)N3C)CCN1C(=O)[C@H1]4CCS4(=O)=O O=C(N[C@H1]1C[C@@H1](CN=C2[NH1]C=NC3=C2CCC3)C14CC4)C5=CN=C(Cl)C=N5 CC(C)OCC1=CN([C@@H1]2CN(C(=O)C3=CC4=CC=CC=C4S3)C[C@H1]2OC(C)=O)N=N1 CCCOCC(=O)N1CCCCC[C@H1](NC(=O)CC2=CC=C3N=C(O)[NH1]C3=C2)C1 C[C@@H1](CCCNC(=O)CC(=O)NCC1CC1)NC(=O)C2=CC(Cl)=CS2 CC[C@H1](C(=O)N[C@H1]1CN(C(=O)C2=CC=CC=N2)CC3=CC=NN3C1)C(C)C C[C@@H1](CNC(=O)C1=CC=C2C=CC=NN12)NC(=O)C3=CC=C(Cl)C(Cl)=C3O CC(C)N1C=NC(C(=O)N2CC=C[C@@H1]2CNC(=O)C3=CN=C(O)C=4C=CSC3=4)=C1 CC=1C=C(C(F)F)OC=1C(=O)NCCC(C)(C)NC(=O)C[C@H1]2CC3CC2C3 C=CCCCC(=O)N(C)[C@@H1]1CN(C(=O)C=2C=CC3=NC=NN3C=2)CC14CC4 CC(=O)N1CC[C@H1](NC(=O)[C@@H1]2CC(F)(F)CN2C(=O)C3=CC(=O)N(C)C=N3)C1 C=CC(C)(C)CC(=O)N[C@@H1]1C[C@@H1](NC(=O)C2=CC=CC=3OC=CC2=3)C14CCC4 C=C(C)CC[C@H1](C)NC(=O)[C@@H1]1C=CCN1C(=O)C=CC2CCCCC2 CC(C)N1CCO[C@H1](C(=O)N2CC[C@H1](NC(=O)[C@@H1](C)[C@H1]3CCOC3)[C@@H1](F)C2)C1 NC1=C(C(=O)NC[C@@H1]2CCCCN(C(=O)[C@]34CCC[C@H1]3OCC4)C2)C=CN=C1Cl CC[C@H1](CC(=O)N1CC[C@](O)(CNC(=O)C=2C=CN(C3CC3)N=2)C1)C(C)(C)C C=C[C@@H1](C)CC(=O)N1C[C@H1](NC(=O)C2=CN=C3C(Cl)=CC=CC3=C2C)C4C[C@H1]1[C@H1]C4 C=C=C[C@@H1](C)C(=O)N[C@@H1]1[C@H1]2CCN(C(=O)C3=CC4=CC=C(Cl)C=C4[NH1]3)C[C@H1]21 C[C@@H1](CC(=O)N1CC(C)(C)C[C@H1]1CNC(=O)C2(Cl)CC2)N(C)C C=C1CC(CC(=O)NCCNC(=O)C2=CC(C3CC3)=NC=4ON=C(C)C2=4)C1 N#CC1=C[NH1]C=NC1=N[C@@H1]2CN(C(=O)CCOCC(F)F)C[C@H1]2C(F)(F)F CCCSCCC(=O)N[C@H1](CC)CNC(=O)[C@H1](C)OC1=CC=C(F)C=C1 CC1=CC(F)=CC=C1C(F)(F)C(=O)N[C@H1]2CN(C(=O)CCOC(C)C)C[C@H1]2C CN1CC=C(C(=O)N2[C@H1]3CC=C(C(=O)N[C@H1](CO)CC4CCC4)[C@H1]2CC3)C1 COCCC(=O)N(C)CC1=CC=C(CNC(=O)[C@H1]2CC3=CC=CC=C3N2C)C=C1 CCCC(C)(C)C(=O)NC[C@H1](C)CC(=O)N[C@H1]1CN(C)C2(CCC2)C1 CCC1=CC(N)=C(C(=O)N2CCN(C(=O)CN3C=NC=C3C)C[C@@H1](O)C2)C(F)=C1 C[C@@H1]1C[C@@H1](CO)N1C(=O)[C@@H1]2CN(C(=O)CCCCC#N)CC2(C)C C[C@@H1](CC(N)=O)NC1=CC=C(S(=O)(=O)N[C@H1]2C[C@H1](C(N)=O)C2)C=N1 CC(=O)[C@H1]1C[C@@]1(Cl)C(=O)N2CCC3=CC=C(C(=O)NOCC4CCC4)N=C3C2 C=CC1(CC(=O)N[C@](C)(CNC(=O)C2=NN=C(O)C=C2O)C(C)C)CCCCC1 CON(CCC(=O)NCCN(C)C1CC1)C(=O)[C@H1](CN(C)C)C(C)C CC[C@@H1](CC(=O)N[C@H1]1C=C[C@@H1](C(=O)NC2=CC(C#N)=CN=C2C)C1)OC C[C@@H1]1CCCC[C@@H1]1NC(=NCC(C)(C)[C@H1]2CCCO2)N3CCCCC3 C=CCNC(=O)[C@H1](C1=CC=CC=2C=C(C)OC1=2)N3CCCC[C@H1]3[C@H1]4CCCO4 CO[C@@H1]1C[C@H1](CNC(=O)C2=CC(C#N)=CC=C2F)N(C(=O)C3=CN=CC(Cl)=C3)C1 COC1=CC=C(NC(=O)[C@@H1](C)C2CCN(CC3=CC=C([S@@](C)=O)C=C3)CC2)N=C1 C[C@@H1](C(=O)N1CCC(F)(C(=O)O)CC1)N2N=NN=C2C(C)(C)C CC1=CC(C(=O)N2C[C@H1]3CCN(C(=O)C4=C(O)C=CC=C4F)[C@H1]3C2)=CO1 O=C(NCCCNC(=O)C=1ON=C2C=1CCC2)C3=CC=C(SC(F)(F)F)N=C3 CC(C)C(=O)NC[C@@H1]1[C@H1](C2CC2)CCN1C(=O)CCC3=CC=CC=C3C#N COC1=CC=C(C(=O)NCC[C@@H1](C)N(C)C(=O)C2([C@H1]3CCCO3)CC2)C(N)=C1Cl CCC=C(F)C(=O)NCC1(OC)CN(C(=O)[C@H1](C)C2=CC=CC(C(F)(F)F)=C2)C1 O=C(NCC1C2C(NC(=O)C3CCCCCC3)(C1)C(F)(F)C2)C4=CC=C(Cl)C=C4 CCCN(CCNC(=O)/C=C/CCC(C)C)C(=O)[C@@H1](C)C[S@@](C)=O C[C@H1](CC(=O)N[C@@H1]1CN(C(=O)C2=C[NH1]C3=CC=C(F)C=C23)C(C)(C)C1)CN(C)C CN1C[C@@H1](O)C[C@H1]1C(=O)N2CCCC[C@@H1]2CCNC(=O)C3(CO)CCCCC3 O=C(CC1=CN=NS1)NC[C@H1](CO)NC(=O)C2=CC=CC(OC[C@@H1]3CCCO3)=C2 C[C@H1](C(=O)NC[C@@H1]1[C@H1](C)CCN1C(=O)[C@H1]2CCC(=O)NC2)C3=CC=C(Cl)C=C3 CO[C@H1](CSC)C(=O)N1CC2(CCC[C@H1](CNC(=O)CCC=3C=N[NH1]C=3)O2)C1 CO[C@@H1](C)C(=O)NC[C@@H1](NC(=O)C=1SC(C2CCCC2)=NC=1C)C3CCCCC3 COCC1=NC=C(C(=O)N[C@H1]2C[C@](F)(CNC(=O)[C@H1](O)C3CCCCC3)C2)S1 CC1=NN(C)C=C1CC(=O)N2CC(CCNC(=O)C[C@H1]3COC(C)(C)C3)C2 O=C(N[C@H1]1CN(C(=O)C=CC=C(Cl)Cl)CC2=CC=CC=C21)[C@@H1]3C[C@H1]3C(F)F CC1=NC(CC(=O)N2CC[C@H1](CNC(=O)C3=C[NH1]C4=CC=C(C)C=C34)C2)=C(C)S1 C=CC[C@H1](CO)NC(=O)C1=CC=C(NC(=O)C2=CC=CC=C2I)N=C1 C[C@H1](NC(=O)CCN1CCCC[C@@H1]1C)C(C)(C)NC(=O)C2=CC=C(Cl)C(Cl)=C2N COC[C@@H1](Cl)C(=O)N(CC=1C=NN(C2=CC=C(F)C=C2)C=1)[C@@H1]3C[C@H1]4C[C@H1]3CN4 CC#CC[C@H1](C)NC(=O)[C@H1](F)C1(O)CN(C(=O)[C@H1]2CC3=NC=CN3C2)C1 C#CC1(N(C)C)CN(C(=O)[C@@H1]2C=CCN2C(=O)[C@@H1]3[C@H1](C#N)C3(C)C)C1 O=C(NCC1(O)CN(C(=O)CC[C@H1]2CCOC2)C1)C=3C=CN4N=NN=C4C=3 CC(C(=O)N1CC[C@H1](C)[C@@H1](CNC(=O)C2=CC(C)=NN=C2C)C1)=C3CCC3 CC1=CC=C2C(=C1)C[C@H1](C(=O)N[C@H1]3C[C@](C)(NC(=O)[C@H1]4C(C)(C)C4(F)F)C3)O2 C#CC[C@](C)(CC)C(=O)N[C@H1]1C[C@@H1](OCC(=O)N[C@H1](C)C=2C=NSC=2)C1 CCN1C=CC([C@@H1](NC[C@@H1]2CCC=CO2)C3=NN=NN3C(C)(C)C)=C1 C=C(Cl)C[C@@H1](NC(=O)CCC1OCCO1)C(=O)NC2=CC=C(N=[N+1]=[N-1])C=C2 CC(C)COCCC(=O)NC[C@H1](CO)CNC(=O)[C@H1](O)C1CCCC1 CC(C)(C)C1=CC=C(N)C(C(=O)N2CC[C@H1]2CNC(=O)[C@@H1]3CC=CCO3)=C1 CC1(C)OCC2=CC=C(C(=O)N3CC4(C3)CN(C(=O)[C@H1]5CC56CC6)C4)C=C2O1 CCCC[C@H1](CNC(=O)C[C@H1](CN(C)C)C(OC)OC)NC(=O)[C@H1]1CC1(Cl)Cl C[C@@H1](CC(=O)N1CC(N(C)C(=O)C2=CC(C(C)(C)C)=NO2)C1)C3=CC=C(F)C=C3 CCN1N=NN=C1[C@@H1](NCC[C@H1](N(C)C)C(F)(F)F)C2=CSC3=C(Br)C=CC=C23 CC[C@](C)(F)C(=O)NCCOCCCNC(=O)C1=NC2=CN=CC=C2S1 CC1(C)OCCO[C@H1]1CC(=O)N[C@H1]2COC[C@H1]2NC(=O)C=3C=CN(C(F)F)N=3 CC1=CN=CN=C1N2CC[C@](O)([C@@H1](C)NC(=O)C[C@H1](C)N3C=CN=C3CC)C2 C/C=C/C[C@@H1](C)C(=O)NCC[C@H1]1C[C@H1](NC(=O)C=C(CC)C2=CC=CC(Cl)=C2)C1 CCC1=NC(CC(=O)N(C)CCN(C)C(=O)C=C2CCCCCC2(F)F)=CS1 CC(C)C[C@H1](C(N)=O)C(=O)N[C@H1](C)CCN(C)C(=O)C1=CC=CC2=C1CCC2 C#CC1(OCC(=O)NC[C@@H1](CNC(=O)C2=CC=NO2)OC)COC1 COCCSCCNC(=O)C[C@@H1]1C[C@H1](C)N(C(=O)C2=CN=CC(F)=C2)C1 CNC(=O)COCC(=O)NCC[C@H1](OC)C(=O)N(C)[C@@H1]1CCOC[C@H1]1C COC1=CC=C(Br)C([C@@H1](N[C@@H1]2CCSC2)C3=NN=NN3C4COC4)=C1 C[C@@H1]1CN(C(=O)C2=CC=CN3C=NC=C23)CC[C@@H1]1NC(=O)CC[C@@H1]4CCOC4 C=CCOCCNC(=NC[C@@H1]1CCCCN1C)NC[C@H1](C)COCC CC1[NH1]C(=NC(=O)C(=O)N2C[C@H1](CO)[C@@H1](C3CC3)C2)C=C4C=NC=C14 CC(=O)N(C)CC(=O)NC[C@H1]1[C@H1](C)CCN1C(=O)C2=C(C)OCC2 C[C@@H1](NC(=O)CNC=O)[C@H1]1CCCN1C(=O)C2=CC=C(C3=CC=CS3)O2 C=CCC(=O)N[C@H1]1C[C@H1](C2=CC=CC=C2)N(C(=O)C3=CC(Cl)=CC4=C3CCC4)C1 CNC(=O)NCCC(NC=1[NH1]C(=NCC2=CSC(Br)=C2)N=C3SC=CC=13)CC C#CCC1(C(=O)N2CCC([C@@H1]3C[C@H1](NC(=O)[C@@H1](C)SCCCC)CCO3)CC2)CC1 CC1(C)CC2=CC(C(=O)NC[C@H1]3C[C@H1]3NC(=O)CCC4=CN=CN4C)=CC=C2O1 COC(=O)C=1C=C(C(=O)NC[C@]2(O)CCN(C(=O)/C(F)=C/CCF)C2)N(C)N=1 CC[C@H1](OC)C(=O)NC[C@H1]1CCC(C)(C)CN1C(=O)[C@@H1]2CCCOCC2 O=C(NC[C@@H1](F)CNC(=O)[C@@H1](O)C1CCCCCCC1)C2=C[NH1]C=C(Cl)C2=O CSC(C)(C)C(=O)NC[C@H1]1C[C@](F)(CNC(=O)[C@]23CC[C@H1](N=[N+1]=[N-1])[C@@H1]2C3)C1 CSC1(C(=O)N2CCO[C@](C)(CNC(=O)[C@@H1]3C[C@H1]3C4CCC4)C2)CC1 COC(=O)CC1(NC(=O)[C@@H1](CNC(=O)C2=CC(OC)=CS2)N(C)C)CCC1 CC(C)(C)C[C@H1](NC(=O)N1C2C(NC3CNC(=O)OC[C@H1]3C2)C1)C(F)(F)F C[C@@H1]1C[C@H1]1CCC(=O)N2C[C@@H1](CNC(=O)CCC3=CC=NC=C3)[C@H1]4CCCC[C@H1]42 C#CCO[C@H1](C)C(=O)N[C@@H1]1CCN(C(=O)[C@@H1](OC)C2=CC=CN=C2)C[C@@H1]1C CC[C@H1](C)C=CC(=O)N1C[C@H1]2C[C@H1](CNC(=O)CC3=CN=CN=C3O)C[C@H1]1C2 CCCC1=NOC(CCC(=O)N2CC[C@H1](CCNC(=O)[C@@H1](C)C3CCC3)C2)=N1 CC1=NN(CC(=O)N[C@@H1]2C[C@H1]3[C@@H1]2CCN3C(=O)[C@H1](C)S(=O)(=O)C(C)C)C(=O)N1C CC(C)[C@@H1](CNC(=O)C1=CC=C(F)C=C1Cl)NC(=O)C=2SN=NC=2C3CC3 CC1(NC(=O)C2=CC(Cl)=C(F)C=C2Cl)CN(C(=O)C(F)F)C1 CN(CC[C@@H1](NC(=O)[C@H1]1C[C@H1]1F)C(C)(C)C)C(=O)C2=CC=CC(C3=CSC=N3)=C2 CC=C(CC)C(=O)N(C)[C@@H1]1CCC[C@@H1](NC(=O)[C@H1](C)[C@@H1](O)[C@H1](C)CC)C1 COC1=CC=C(C(=O)NC[C@H1](C)CNC(=O)C2=CC=C(C3CCCC3)C=C2)N=N1 CC[C@@H1](C(=O)N1CCC[C@@H1](N2C=C(C3=CC=CC=C3F)N=N2)C1)[C@H1]4CCC(=O)N4 CSC1=NC=C(C(=O)NCC2(NC(=O)[C@@H1]3[C@@H1](C)C[C@H1]3C)CCC2)N1C CC1(C)CC[C@H1]1C2=CC=C(C(=O)O[C@H1]3CCC4=NC(C5CC5)=NC=C4C3)C=C2 O=C(N[C@H1]1C[C@H1](O)C[C@@H1]1O)[C@H1]2[C@H1]3CCC[C@H1]3CN2C(=O)C4=CC=C[NH1]4 CC(C)N=C1N=C(N(C)CC2=CC=CC(CS(N)(=O)=O)=C2)C3=C([NH1]1)CCC3 C[C@H1]1OC(=O)N[C@H1]1C(=O)NC[C@H1]2CCC[C@@H1](NC(=O)[C@@H1]3C[C@@H1]4C=C[C@H1]3CC4)C2 CN1C=C(C(=O)N[C@@H1]2CC[C@@](C)(CNC(=O)C3=CCCOCC3)C2)C=N1 CC1=CC(C)=C(F)C(C2=NC3=C(S2)C[C@H1](C(=O)N4CCC(F)(F)C4)CC3)=C1 CCC1=CC(C(=O)N[C@@](C)(CO)CNC(=O)C=2C=CN3C=NN=C3C=2)=CC=C1C CCOCC[C@H1](NC(=O)C1=CSC(CC)=N1)C(=O)N[C@@H1](C)CC2=CC=NC=C2 CSCC1(CC(=O)N2CCC(N(CCO)C(=O)[C@@H1]3CC[C@H1](C)S3)CC2)CCC1 CCCCOC1=CC=C(C2=C[NH1]C(C(=O)NC3=NC(Cl)=C(OC)C(Cl)=N3)=C2)C=C1 CNC(=O)CCC(=O)N[C@H1]1CCC[C@H1]1NC(=O)COCCOC2=CC=CC=C2 CC(C)(C)[C@@H1](O)C(=O)N[C@@H1]1CN(C(=O)CCOCC2CC2)CC3=CC=NN3C1 CC1=CC=CC(CC(=O)N2CCCC[C@H1](N(CCO)C(=O)[C@H1]3CC34CC4)C2)=C1Cl COCN1N=CC=C1C(=O)N[C@@H1]2C[C@H1]3CN(C(=O)C=4C=CSC=4OC)C[C@H1]32 C=C(Cl)CCC(=O)NC[C@H1]1CCCCN1C(=O)C2=CC=C(OC)C=C2N CN(CCCOC1=CC=CC(Cl)=C1)C(=O)C[C@@H1]2CCCC3=CC=CC=C32 O=C(NC1=CC=C2N=C(Cl)SC2=C1)C3=CN=C(C4=CC=CC=N4)N=C3 C[C@H1](NC(=O)CC[C@@H1](C)C#N)C1=NC(C(=O)N[C@H1](CO)C(N)=O)=CO1 CC(C)[C@@H1](CNC(=O)CN1N=NC2=CC=CC=C21)NC(=O)[C@@H1]3C[C@]3(C)C(F)F CC(C)[C@]1(C(=O)N2CC[C@H1]2CF)CCCN1C(=O)C3CC(=O)CC(=O)C3 CCC=1OC=NC=1C(=O)N[C@H1]2CN(C(=O)CC3=CC=C(Br)C=N3)C[C@H1]2C CC=1[NH1]N=C(Cl)C=1C(=O)N[C@H1]2CCCC[C@@H1]2NC(=O)C3=CSC([N+1](=O)[O-1])=C3 O=C(NC[C@@H1](C1=CC=CN=C1)N2CCCC2)[C@H1]3CS(=O)(=O)CCN3 CC=C[C@@H1](O)C(=O)N[C@H1]1C=CCN(C(=O)C[C@H1](C)C2=CC=C(F)C=C2)C1 COC1=CC(NC(=O)N[C@H1]2C[C@@]23CCCC4=CC=CC=C43)=CC=C1C COC1=NC=C(C(=O)N2C[C@H1](NC(=O)[C@H1]3COCCO3)CC4(CC4)C2)C(C)=N1 COCC1(C(=O)NC2(CNC(=O)[C@@H1]3CCC[C@H1](C(N)=O)CC3)CCC2)CC1 C[C@H1]1CO[C@@H1](C(=O)NCCCC(C)(C)NC(=O)CC=2C=NN3C=CC=CC=23)C1 O=C(CN1N=NN=C1C2CC2)NC3(CNC(=O)[C@@H1]4C[C@H1]4C(F)F)CCC3 CN(CC1=CC=CC=C1N)CC2=C[NH1]C3=NC=CC=C23 C=CCC1(NC(=O)COC(F)(F)F)CN(C(=O)C2=CN(C)C(=O)N=C2O)C1 C#CC1(C(=O)NC2=CC=C(O)C=C2CC)CN(C(=O)[C@H1]3CC(=O)CC34CCC4)C1 COC(=O)C1=CC(C(=O)N2CCN(C(=O)[C@H1](C)CC(F)F)[C@H1]3CCC[C@H1]32)=C(C)S1 CCCC[C@H1](CNC(=O)[C@](C)(O)CCC)NC(=O)[C@H1]1CCC[C@H1](C(N)=O)C1 CC1=CC=CC=C1COC2=CC=C(CN(C=O)[C@@H1]3CN(C4CC4)C[C@@H1]3C)C=C2 CC(=O)NCCC(=O)NCC(=O)N[C@H1]1C[C@H1](CNC(=O)[C@@H1]2CCC2(F)F)C1 C#CCC(CC#C)C(=O)N[C@@H1](CCOC)CNC(=O)[C@@H1](C)SC1=CC=CC=C1 C[C@](O)(CO)CNC(=O)C[C@H1](CC1CC1)NC(=O)C2=CN=C[NH1]C2=N CC(=NO)[C@@H1]1C[C@H1](C(=O)N2CC[C@H1](C)[C@H1](NC(=O)[C@@](C)(O)C3CC3)C2)C1(C)C COCC(F)(F)C(=O)N1C[C@@H1](C)[C@H1](CCNC(=O)C2=C(C(C)C)OC=C2C)C1 C[C@H1](CC(=O)N(C)[C@@H1]1CCN(C(=O)C2=CC3=C[NH1]C=NC3=N2)C1)P(C)(C)=O CC(C)S(=O)(=O)CC(=O)NC[C@]1(F)C[C@@H1](NC(=O)[C@@H1]2CNC(=O)C3=CC=NN32)C1 CC1=CC(=NC[C@@H1]2CCSC2)[NH1]C(=NCCC(F)(F)Cl)[NH1]1 COC1=CN=CC=C1CN[C@@H1]2CC[C@@H1](C(=O)NCC3=CC=C(Cl)S3)C2 COC[C@](C)(O)C1=CN(CCCCCNC(=O)CN2CCC[C@@H1]2CO)N=N1 COC1(C)CN(CC(=O)N[C@@H1]2CN(C(=O)[C@@H1]3CN4CCC[C@H1]3C4)[C@H1]5CCC[C@H1]25)C1 CN1C=CN=C1C(=O)NC2CC(NC3=CC(=O)N4C=C(Cl)C=CC4=N3)C2 CN1CC[C@H1](C(=O)NCCOC2CN(C(=O)[C@H1]3C[C@H1]4CC[C@H1]3C4)C2)C1=O CC[C@H1]1CN(C(=O)CCNS(C)(=O)=O)CCN1C(=O)C2=CC=CC3=C2CCC3=O CC(C)[C@@H1]1CN(C2=NC=3C=C[NH1]C=3C(=NC[C@H1](C)CCO)[NH1]2)CC(=O)N1 CCOCCC(=O)N[C@H1](CCN(C)C(=O)[C@H1](NS(C)(=O)=O)C(C)(C)C)C(C)C CC=1N=CN(O)C=1C(=O)N2CC[C@](O)([C@@H1](C)NC(=O)C3=CN=C(O)S3)C2 O=S(=O)(N[C@@H1]1CCN(CC2=CC=C(I)C=C2)C[C@H1]1F)C3=CC(Cl)=CC(Cl)=C3 CC(=O)N[C@@H1](C(=O)NC[C@H1]1CCCN(C(=O)C2=CC=C3N=CSC3=C2)C1)C(C)C CC1CC2(C1)CC(C(=O)NCC3(C(N)=O)CN(C(=O)CC[C@H1]4CCCCO4)C3)C2 C[C@@H1](NC(=O)C1CCC1)C(=O)N2CC3=C(C2)CN(C(=O)C(C)(C)C4=CC=CS4)C3 CC[C@H1]1CCO[C@H1]1C(=O)NCCOCCNC(=O)[C@@H1]2C[C@H1]2C3CCCC3 CCN(CC1=CC=C2C(=C1)C[C@H1](C)O2)N(C)CCN3N=CN=C3C COC1=CC(OC)=C2[NH1]C(C(=O)N3CCC[C@@H1](CC4CNC4)C3)=CC2=C1 CC[C@H1](C(=O)NCC[C@@H1](O)CNC(=O)C1=CC=NN=C1C)N2C=NC=N2 CC1(C)CCO[C@@H1]1CC(=O)N[C@H1]2C[C@@H1](NC(=O)C[C@H1]3C[C@H1]4C=C[C@H1]3C4)C2 C[C@H1]1CN(C(=O)C=CCO)CC[C@H1]1NC(=O)C2=CC(F)=C(O)C(Cl)=C2 C[C@@H1](CNC(=O)C1=CC=C([N+1](=O)[O-1])C=C1)NC(=O)COC2CC(F)(F)C2 CNC(=O)C(C)(C)C(=O)N(C)CCNC(=O)[C@@H1]1C[C@@H1](O)[C@H1](NC(=O)[C@@H1](C)O)C1 CC1=N[NH1]C(C)=C1[C@H1](C)CC(=O)N[C@H1]2CCCCN(C(=O)[C@H1]3COCCO3)C2 CC1=CC(NC(=O)C[C@@H1]2CC(C)(C)CN2C(=O)CN3CC=CC3)=CN=C1C COC1=NC=CC=C1C(=O)N[C@@H1]2CC[C@@H1](N(C)C(=O)C3=CC=NC(C(N)=O)=C3)C2 COC(C)(C)C(=O)N1CCC[C@H1]([C@@H1](C)NC(=O)C2=CC=C(C(C)(F)F)N=C2)C1 CCCCCCC=1C=C(CNC2(C3=CC=NC=C3)CC2)SC=1Cl CC[C@H1](CC(F)F)C(=O)NC[C@@H1]1C[C@H1](OC)CN1C(=O)CN2C(=O)CN(C)C2=O COC1(C(=O)NC[C@H1]2COCCN(C(=O)CC34COC(C)(C3)C4)C2)CCC1 CCOC1=CC=CC(C2=CC=CC3=C2CN(C(=O)CC4=CC=C(F)C=N4)CC3)=C1 CCCC(=O)N[C@@H1]1CCN(C(=O)C2=CC(C)=C(F)C=C2N)C[C@@H1]1F C=C[C@@H1](CC)CC(=O)N[C@H1](C)C1CCN(C[C@H1](OC)C2=CC=CC=C2)CC1 CCCCCCCCC[C@H1](O)C(=O)N1CCC(NC(=O)[C@@H1](C)CSC)CC1 O=C1C[C@H1](C(=O)N2CC3(C2)CN(C(=O)[C@H1]4CCC4(F)F)C3)CN1 CCOC(=O)[C@H1](F)C(=O)N1CCC(N2C=C(CNC(=O)CCCSC)N=N2)CC1 CC(C)=C(C)C(=O)NC[C@H1](O)C1CCN(C(=O)CN2C[C@H1]3C[C@H1]3C2)CC1 CC[C@@H1](C(=O)NC[C@@]12C[C@@H1](CO1)N(C(=O)C3=C(C)C=CC=C3F)C2)N4C=NC=N4 C=CCC1(NC(=O)[C@@H1](C)CC2=CC=CC=N2)CN(C(=O)C3=C(C#N)C=NN3C)C1 CCS(=O)(=O)N[C@H1](C)C(=O)NC[C@H1](CO)CNC(=O)CCC1=NC=C(F)C=N1 CC12CC(C(=O)N[C@H1]3C[C@@](F)(CNC(=O)C4=CC=CC(F)=C4OC)C3)(CCO1)C2 N#CCC1CN(C(=O)[C@H1]2CSCCN2CC3=CC=NC=C3F)C1 N#CC1CC(NC(=O)C2(CNC(=O)CCC3=NC(O)=N[NH1]3)CC4(CC4)C2)C1 CCC1=NC(C)=CC(N2CC[C@]3(CNC(=O)[C@@H1]4C[C@@H1]4C(=O)OC)CCCC[C@@H1]23)=N1 CC1=CC=C(C(=O)N2CCC(O)(CCNC(=O)C3=N[NH1]C=C3C(F)(F)F)CC2)[NH1]1 CC1=NOC(C)=C1CC(=O)NCCN(C(=O)[C@@H1]2COCC3(CCC3)O2)C(C)C CC(C)C1=CC=CC(CC(=O)N2CC(F)(CNC(=O)C3(N4C=NC=N4)CC3)C2)=C1 CC1=CC=C(CCC(=O)N[C@H1]2CN(C(=O)CC(F)(F)C(F)F)CC[C@H1]2F)O1 C#CC(C)(C)C(=O)N1CCN(C(=O)CC2=C[NH1]C3=CC(OC)=CC=C23)C[C@@](C)(F)C1 COCCCN1N=NN=C1[C@@H1](NCCCNC(=O)OC(C)(C)C)[C@H1]2C[C@@H1](OCOC)C2 C[C@H1](NCC(=O)NC(C)(C)C1=NC2=CC(Br)=CC=C2O1)[C@@H1]3CCCCC3(F)F CC1=NC=C(C(=O)N[C@@H1]2CN(C(=O)C=3C=NN(C(C)C)N=3)C[C@H1]2O)C(=N)[NH1]1 C=C(C)C[C@@H1](NC(=O)C1=CC(O)=NN1C)C(=O)NCC[C@H1]2CCCC2(C)C CC(C)OC1(CNC(=O)[C@H1]2CCCN(C(=O)[C@@H1]3CCC4(CC4)C3)C2)CCC1 CC1=CC(=O)OC(C)=C1C(=O)N2CCO[C@@]3(CCN(C(=O)[C@@H1]4CCCCS4)C3)C2 C[C@@H1](C1=CC=CS1)N(C)C(=O)[C@H1]2CC=C[C@H1](NC(=O)CC3=CN=CS3)C2 CO[C@H1](C(=O)N1C[C@H1]2C[C@@H1]1[C@H1]2NC(=O)C3=CN=CC(Br)=C3)C(C)(C)C CCSCC1=NC(C)=C(CC(=O)N2C[C@H1]3C[C@@]3(NC(=O)C(=O)N(C)C)C2)S1 C[C@@H1]1C[C@@]2(C(=O)NCCOCCN(C)C(=O)C3CN(S(=O)(=O)C(F)F)C3)C[C@@H1]12 CC(C)CCC[C@H1](C)C(=O)N1C[C@H1]2[C@H1](CNC(=O)[C@H1]3CC34CCCCC4)C[C@H1]2C1 CC=C(CC)C(=O)N1C[C@H1](NC(=O)C2=NC(CC)=NC=C2Cl)C[C@@]1(C)COC CCN1CC[C@H1](C(=O)N2C[C@H1]3CC[C@@](C(=O)NC4=CC=C5N=C[NH1]C5=C4)(C3)C2)C1 CC(C)NC1=CC=C(C(=O)NC[C@@H1](C)N(C)C(=O)[C@H1]2CCCCS2)C=N1 C[C@@H1](NC(=NCCC1=CC=CN=C1)NC[C@H1]2C[C@@H1]2Cl)C=3C=CN(C)C=3 NC(=O)C=1C=C(C(=O)N[C@@H1]2CC[C@H1](CNC(=O)[C@@H1]3[C@H1]4CCCO[C@H1]43)C2)N5C=1CCC5 CC1=CC=C(N(C)C(=O)[C@@H1]2CN(C(=O)C3=CN=C(Cl)S3)CC24CC4)C=C1C O=C([C@@H1]1CCSC1)N2CCC(CCCCNC(=O)C3(F)CCOCC3)CC2 CC=1C=C(C(=O)NC[C@@H1]2CC3(CO2)CN(C(=O)C=4C=C(C(F)F)[NH1]N=4)C3)SC=1C COCCOCCOCC(=O)N[C@H1](C)CCNC(=O)[C@H1]1CCCC[C@H1]1C(C)(C)C CCN(C)CC(=O)N1CCC[C@@H1](N(C)C(=O)C2=CC=C3C(=C2)OCCO3)C1 CC=1N=C(CO)SC=1C(=O)N[C@@H1](CO)CNC(=O)C2CCC(N3C=CN=N3)CC2 CSC(C)(C)/C=C/C(=O)N1CCC[C@@H1]1CNC(=O)C2=CC(N)=C(F)C(F)=C2F C[C@@H1]1CN(C2=NN=C(C3=CC=CN=C3)N2CCCCO)C[C@@H1](C(F)(F)F)O1 C[C@@H1](NC(=O)CC=1N=C[NH1]N=1)[C@@]2(O)CCN(C(=O)C=CC3CCOCC3)C2 CC[C@@H1](NC(=O)N(C)CC1=CC=C(N2CCCC2)C=C1)C3=CC=CC=C3Br CC1=NOC(CCC(=O)N2C[C@H1](C)[C@H1](NC(=O)C3COC3)C2)=N1 C[C@H1](CC(N)=O)C(=O)N1C2[C@@]3CCC[C@]3(CN(C(=O)CS(=O)(=O)C4CC4)C2)C1 CCC(CC)CCCC(=O)NC[C@H1]1CCCCN1C(=O)[C@@H1](C)CCC(=O)OC CC1=CC(Br)=CC(C(=O)N[C@H1]2CC[C@@H1](N(C)C(=O)CCC3=CN=C[NH1]3)C2)=C1 O=C(C#CC1CCCC1)N[C@H1]2C=C[C@@H1](C(=O)N3CC[C@@H1]4C[C@@H1]43)C2 CCCCC[C@@H1](C(=O)N1CCC(OC)(C(=O)N2CCCC(C)(C)C2)CC1)C(C)C CCCC[C@H1]1CN(C(=O)CN(C)C(N)=O)CCN1C(=O)[C@H1]2CCCN3N=CC=C32 CC=CC(=O)N1[C@@H1]2CC[C@@H1](C2)[C@H1]1CC(=O)NCC3=NN=C4N3CCC4 CC[C@H1](C)C(=O)N1C[C@@H1]2CCN(C(=O)C3=CSC4=CC=CN=C34)C[C@H1]21 COC(=O)C1=CC(C(=O)NC2CN(C(=O)CC3=CC=CC=C3OC)C2)=C(F)C=N1 C[C@@H1]1CCN(C(=O)C2=CC=CN=N2)C[C@@H1]1N(C)C(=O)C3=CC(CC4CCC4)=C[NH1]3 N=C1N=NN(CC(=O)N2CCN(C(=O)CC=3C=CSC=3Br)[C@H1]4C[C@@H1]42)[NH1]1 CC[C@H1](CNC(=O)C1=C(C)C=CC=C1Cl)NC(=O)C2=CC3=CC=CC=C3N=C2O CCC(C)(C)N1N=NN=C1[C@]2(N[C@H1](C)CCOC)CC[C@H1]3[C@H1]4CC[C@@H1](C4)[C@H1]32 CC(=O)N[C@@](C)(CO)C(=O)NC[C@H1]1CC2(CCN(C(=O)CNC(N)=O)CC2)CO1 C[C@H1](CNC(=O)[C@H1](C)CC(C)(C)C)CC(=O)NC1(C)C(C)(C)C1(C)C CC(C)[C@@H1](C(=O)N[C@H1]1CC[C@@H1](O)CN(C(=O)CCCC2=NC=CS2)C1)N(C)C CCCOC1=CC=C(CNC(=O)NC2=CC=C3C(=C2)CCCC3)C=C1 CC[C@H1](C(=O)N[C@H1](C)CCCC(=O)NC[C@H1]1COC[C@H1]1O)C(C)C CC(=O)NCCCCCC(=O)NCC[C@@H1]1CSCCN1C(=O)COC=2C=N[NH1]C=2 CCSCCC(=O)NC[C@@H1]1CC[C@@H1]1NC(=O)[C@@H1](CN(C)C)C2=CC=CC=C2 CC1=CC(F)=CC(N2N=C(C3=CC=C(C)O3)N=C2[C@@H1]4C[C@H1]4C5CCC5)=C1 CC[C@](C)(CCNC(=O)[C@@H1](F)[C@@H1]1CCOC1)NC(=O)C2=CC=C(OC)C=C2 CCNC(=O)C(=O)N(CC)CCNC(=O)C=CC1=CC=CC=C1O O=C(C1=CN=C2N1CCC2)N3C[C@]45CCC[C@]4(C3)CN(C(=O)C6=CC=NS6)C5 O=C(C1=C(I)C=CN=C1Cl)N2CC[C@@H1](C(=O)N3CCN4C[C@@H1](O)C[C@@H1]4C3)[C@H1](O)C2 CN(C(=O)[C@H1]1CCC(=O)N1)[C@@H1]2CCCC[C@@H1]2NC(=O)C=CCO COCC[C@H1](OC)C(=O)N1CCC[C@H1]1/C=C/C(=O)N(C)C2(C3CC3)CC2 C[C@@H1]1C(=O)N(CC(=O)N[C@H1]2C[C@H1](F)CN(C(=O)COC=3C=CSN=3)C2)C(=O)[C@@H1]1C C[C@@H1](CCN(C)C)C(=O)NC1(CCC(=O)NC[C@@H1]2CCOC(C)(C)C2)CCCC1 COC1=CC=C(CCN=C(NCC2=NN=NN2C3CCC3)N4C[C@H1](C)C[C@@H1](C)C4)C=C1 CCOCC(C)(C)C(=O)N[C@@H1]1CS(=O)(=O)C[C@H1]1NC(=O)C2(C(C)(C)OC)CC2 COC1=CC=CC(C)=C1C(=O)NCCC(C)(C)CNC(=O)[C@@H1](C)[C@H1](O)C(C)C C[C@@H1](NC(=O)C1=CN=C2C=CC=NC2=C1)[C@@H1]3CCCN3C(=O)C4=COCCC4 CC1(C)CCCC[C@H1]1CC(=O)OCC2=CC=CC(Cl)=C2 CS[C@H1]1C[C@H1](CC(=O)N[C@@H1](C)C2(O)CN(C(=O)C3=CC(C)=C(C)S3)C2)C1 C=CCCO[C@H1](C)C(=O)N[C@H1]1CC[C@H1]1CNC(=O)C=C(C)CCOC COCCN1C=CC(C(=O)N[C@@H1]2CC[C@@H1]2CNC(=O)CCN3CCCC[C@H1]3C)=N1 NC1=CC=C(N2C=C(C3(NC(=O)CC4=CC=CO4)CCC3)N=N2)C=C1F C=C1COCCN(C(=O)[C@@H1](C)N(CC)C(=O)[C@@H1]2CC2(C)C)C1 O=C(N[C@@H1]1C[C@H1](C(=O)NC[C@@H1]2C[C@@H1]2Cl)C[C@H1]1O)C3=C[NH1]C4=CC=CN=C34 C[C@H1](NC(=O)[C@]1(C(F)(F)F)C[C@@H1](O)C1)[C@H1]2CN(C(=O)CCN3CCCC3)CCO2 CC(C)[C@H1](NC(N)=O)C(=O)N(C)C[C@H1]1CCN(C(=O)C2(N(C)C)CCOCC2)C1 CC[C@@H1](CN(C)C(=O)CCCC(F)(F)CO)NC(=O)[C@@H1](SC)C1CC1 CCC[C@](C)(O)CC(=O)NC[C@@H1]1CC(C(=O)NC[C@@]2(C)CCC(=O)N2)=NO1 CC(C)(CNC(=O)[C@@H1]1CCCC[C@H1]1C(F)(F)F)C2=CC=CC(F)=N2 CC1=CC(C2=CC=NC=C2C#N)=CN=C1NCC3=CC=CC(OC(C)C)=C3 CN1N=CN=C1COCC(=O)N2CCC[C@@H1]2CCNC(=O)CSC[C@H1]3CCCO3 CN(C[C@H1]1CN(C(=O)C(=O)NC2CC2)CCO1)C(=O)[C@H1]3C[C@H1]4[C@@H1](C3)C4(C)C CC1=NOC(Cl)=C1CC(=O)N2C[C@@H1](NC(=O)C=3N=COC=3C4CC4)[C@H1](C)C2 O=C([C@@H1]1CCCC2=CN=CN21)N3CCC4(CCN(CC5=CN=CN=C5)CC4)CC3 CC1=CC=CC2=C(C(=O)N[C@]3(C)C[C@H1](NC(=O)C4CCS(=O)CC4)C3)C=CC=C12 CO[C@H1](CN(C)C1=NC(NCC(C)(C)C)=C2C=C(Cl)C=CC2=N1)C(C)C C[C@H1](O)C(=O)N(CCC(=O)N1CCCC[C@H1]1CCCO)CC2CC2 CCOC=1C=C(C(=O)N2CC[C@@H1](C3(NC(=O)CC4=C[NH1]C=CC4=O)CC3)C2)ON=1 CCN(C(=O)C1CC2(CSC2)C1)C3CCN(C(=O)C4=CC=CC5=C4C=CO5)C3 C=CCC(C)(C)CC(=O)N1C[C@H1](CNC(=O)CCSCC(N)=O)C(C)(C)C1 O=C(NC1=CC=C(Cl)C(CO)=C1)[C@H1]2CCCN2C(=O)C3=CC=CC4=C3CCC4 CCC1=CN2C(=N1)C[C@@H1](C(=O)N[C@@H1]3CCCC[C@@H1]3NC(=O)C(F)F)CC2 O=C(N[C@@H1]1C[C@@H1]2CC[C@H1](C1)N2C(=O)CN3N=C4N(C3=O)CCOC4)C5CCC5 CC(C)(C)OC(=O)N1C[C@H1](F)CC[C@@H1]1C(=O)NC[C@H1](CO)CC2=CC=CC=C2F C#C[C@H1](CC)NC(=O)[C@H1](CC)N(C)C(=O)C[C@H1]1CCC(=O)[C@@H1]1C COC(=O)[C@@H1]1CC[C@@H1](C(=O)N2CCC(CCNC(=O)C=CSC)CC2)C1 O=C(N[C@H1](C(=O)NC1CCCC1)[C@@H1]2CCCO2)C3=CC=NN=C3 CC1=CC=C(C2=NO[C@@H1](CNC(=O)C=3N=NSC=3C4=CC=CC=C4)C2)C=C1 CCOC(=O)C1(C(=O)NC[C@@H1](C)CN(C(=O)C(F)(F)C2CC2)[C@H1](C)CC)CCC1 CC(C)CCSCC(=O)NC[C@@]12CC[C@@H1](C1)N(C(=O)CC=3C=C[NH1]C=3)C2 CCN1C=CN=C1C(=O)NC2=NC(C3=CC=C(OC)C(OC)=C3)=CS2 CC(C)(C)C1=NC=CC(OC(=O)C[C@@H1]C2[C@@]3(CCNC3)C(=O)OC2=CC=CF)=C1 C=CCO[C@@H1](C)C(=O)NC1(CO)CN(C(=O)C2=CC(C)=CC3=C2NCCC3)C1 CC(=O)NC1=C(C)C=CC=C1C(=O)N(C)CCCOCCNC(=O)C(C)=C(C)C CCN1CCO[C@@H1](C(=O)NC2[C@](C)(CNC(=O)C[C@H1]3CC4(CC4)CO3)CC2(C)C)C1 CCC(F)(F)CC(=O)N1CC2(C[C@@H1](C(=O)N(C)CCC(C)(C)O)CO2)C1 N#C[C@H1]1CC[C@@H1](NC(=O)C(=O)N2CC[C@@H1](C3=CC=CC(OC(F)(F)F)=C3)C2=O)C1 O=C([C@H1]1CCN(CC2=CC3=NC=CC=C3O2)C[C@@H1]1O)N4CCC(O)(CO)CC4 CC=1SC(O)=NC=1C(=O)N2C[C@H1]3C[C@@H1](C(=O)N4CC(C[S@@](C)=O)C4)C[C@H1]3C2 CO[C@@](C)(C(=O)NCCN(C(=O)C1=CC2=CC=C(Cl)N=C2S1)C3CC3)C4CC4 O=C(N1CC[C@H1](C2=CC=C(F)C=C2)C1)C3(N4C=C(COCCCO)N=N4)CC3 COC(=O)C=1SC=CC=1C(=O)N[C@@H1](C)C[C@@H1](C)NC(=O)COCCCN(C)C NC(=O)CCCCC(=O)N1C[C@@H1]2C[C@H1](C1)[C@H1](NC(=O)C3=C[NH1]N=C3C(F)(F)F)C2 CS[C@H1](C)C(=O)N1C[C@@H1](O)[C@@H1](O)[C@@H1]1CNC(=O)C2=CN=CC(N3CCCC3)=N2 O=C(N[C@@H1]1CN(C(=O)C2=CN(C3CC3)N=N2)CC[C@H1]1O)C4=NSC5=CC=CC=C45 CC[C@H1](C)C(=O)NCC(=O)NC(C)(C)[C@H1]1CCN(C(=O)C2=CC=CO2)C1 CCOC[C@@H1](C)C(=O)N1CCC[C@@](C)(CNC(=O)C=2SC3=NC=CN3C=2C)C1 CSC1=NC=C(C(=O)N[C@@H1]2CCC[C@@H1](NC(=O)C3=CC=CC(Cl)=C3)CC2)N1C CCOC(=O)[C@H1](F)C(=O)N[C@@H1](C(=O)NC1=CN=CC=C1C)C=2C=NN(C)C=2 CC(C)(C)C#CC(=O)NC[C@H1](O)CCNC(=O)CN1CCN(C2CC2)C1=O O=C(NCCNC(=O)C1(C2CC2)CCOCC1)C3=CC(F)=CC=4N=N[NH1]C3=4 CSC1=CC=C(C)C(C(=O)NC2CC3CC(CCN3)C2)=C1 COC(=O)C1=CC=NC(CN2C[C@@H1]3C[C@H1]2CN3C4=NC=CC(OC)=N4)=C1 CCCN(CCNC(=O)[C@H1]1CCCN1C=O)C(=O)CCC2=NC(C)=C(C)[NH1]2 O=C(CC1=CC=C(CO)C=C1)NC2CC3(C2)C[C@@H1]3NC(=O)C4=CCOCC4 CC1=C(F)C=C(Br)C=C1C(=O)NC2CC(C(=O)NC3=CN=CC=N3)C2 CCC(=O)NCC(=O)N1CCC[C@@H1](CN=C2[NH1]C(Cl)=NC(C)=C2C#N)C1 CC[C@@H1](OC)C(=O)N1CCO[C@H1](CNC(=O)C2CCC(C)(C)CC2)C1 CC1=N[NH1]C=C1CC(=O)N[C@@H1]2CC[C@H1](CNC(=O)C=3C=CC4=N[NH1]C=C4N=3)C2 C[C@@H1](C#N)C(=O)N[C@H1]1CCCC[C@H1]1N(C)C(=O)CNS(C)(=O)=O COC1=NC=C(C(=O)N2C[C@@H1](C)C[C@@H1](C(=O)NC3=CN(C)N=C3C#N)C2)C=C1C CCSCCC(=O)N1CCCO[C@@H1](CCNC(=O)C2=NOC3=C2CCCCC3)C1 CN(C)CCCCC(=O)N1C[C@@H1]2C[C@H1](C1)CN2C(=O)C=CC#N CC1(C)CCO[C@H1](C(=O)N[C@H1]2CCCCCC[C@H1]2NC(=O)C3(C)CC3)C1 COC1=CC=C(C(=O)N[C@H1]2CCN(CC3=CC=NC(Br)=C3)[C@@H1](C)C2)C=C1 CC(C)C1=CC=C(C(=O)N[C@H1]2CCN(C(=O)CCC3=NC=CN3C)[C@@H1]2C(C)C)O1 CCCC[C@@H1](CNC(=O)COCC)NC(=O)C1=CC=C2C(=C1)S(=O)(=O)CCC2 COCC1(CC(=O)N2CC(C)(NC(=O)CN3CCC(CO)CC3)C2)CC1 C[C@@H1]1CN(C(=O)[C@H1]2CN(C)C[C@@H1](C)O2)C[C@@H1]1NC(=O)C3(C)CC3 COC1=CC=CC=C1C(=O)C(=O)NC2(C)CN(C(=O)C=CC3=CC=CC=C3F)C2 CN1C(=O)CC[C@@H1]1CC(=O)N[C@H1]2C[C@]3(CCCCN3C(=O)/C(Cl)=C/Cl)C2 O=C(N[C@H1]1CCCCN(C(=O)C2=CC(Cl)=CN=N2)C1)[C@@H1]3CCN3C4CCCC4 CO[C@H1](C)C(=O)N1CC=C[C@H1](NC(=O)C=2SC=C3C=2OCCO3)C1 C[C@H1](CC1CN(C(=O)C2=NC(Cl)=CS2)C1)NC(=O)[C@H1](C)C3CC3 CC(C)CCC(=O)NC[C@H1]1CCC[C@H1]1C(=O)N(C)CC(=O)N(C)C O=C(N[C@@H1]1CN(C(=O)C[C@@H1]2C[C@H1]2C3=CC=CC=C3)C[C@@H1]1F)C4=CC(Cl)=CC=N4 CC1=CC(F)=CN=C1C2=CN(C[C@H1]3CCCN3C(=O)C=4C=C(C)N(C)C=4)N=N2 COC1=NC=C(C2=CC=3C(C(=O)NC4=CN=CC(O)=C4)=COC=3C=C2)C(OC)=N1 CCO[C@@H1](C)C(=O)N1CC(CO)(NC(=O)C2=CC=CC(OC(F)F)=C2)C1 CCCC(=O)NC[C@]1(F)C[C@H1](CNC(=O)[C@H1](OC)C2CCCC2)C1 CCC(CC)C(=O)N[C@H1]1C[C@H1](CNC(=O)C2CCN(C(=O)CC(C)(C)C)CC2)C1 C=C(F)C1(CC(=O)NC[C@@H1](O)CC(=O)N[C@H1](C)C2=CC=NS2)CCC1 CC1(C)CN(C(=O)[C@H1](F)CC2CN(C(=O)C=C(C3CC3)C4CC4)C2)CC[C@@H1]1O C=CC[C@@H1](CNC(=O)C1(C)CCC(C)CC1)C(=O)N2CC(SCC)C2 CC[C@@H1](C(=O)NCC12CC(NC(=O)C3=NO[C@@H1](C)C3)(CCO1)C2)N(C)C CCC1=CC=CC=C1C(=O)N[C@@H1]2[C@@H1](C)CN(C(=O)C=3OC=NC=3C)C[C@H1]2C C[C@@H1]1CO[C@H1](C(=O)N2CCC[C@@](C)(NC(=O)[C@H1](C)CO)C2)C1 CCC1=CC=C(C(=O)N2C[C@H1]3CC[C@H1]2[C@@H1](CNC(=O)CCCC4=CC=CS4)C3)[NH1]1 CCOC(C)(C)C(=O)N1C[C@H1](O)C[C@H1]1C(=O)N2CCCOC(C)(C)C2 O=C(NCC1=CC=NC(Cl)=C1)[C@@H1]2CCCN2C(=O)[C@H1]3CCC[C@H1]3F CC(C)(C(=O)N[C@@H1]1CCC[C@@H1](NC(=O)C=2C=NSC=2)C1)C3=CC=CN=C3 CC1=CC=C(CNC(=O)[C@@H1]2C[C@H1](F)CN(C(=O)C3=NC=C(C)S3)C2)N=C1 COC1=CC=C(NC(=O)[C@]2(C)C[C@H1](O)CN2C(=O)C[C@@H1]3CCOC3=O)C=N1 CCN(CCC(=O)NC)C(=O)[C@H1]1CCC[C@H1]1CNC(=O)C(C)(C)C2CC2 CCN1N=CC=C1[C@@H1](C(=O)NCC2=CC=CC(Cl)=C2)N3CCOC[C@H1](O)C3 CN(C)CCCCCC(=O)NCC1=C[NH1]N=C1C(=O)NC(C)(C)C[C@@H1]2CCOC2 CCC[C@H1]1CN(C(=O)[C@H1](F)C(C)(C)O)C[C@H1]1NC(=O)[C@@](C)(O)C(F)(F)F CC(C)N1CCC[C@H1](C(=O)N[C@@](C)(CNC(=O)C2=CC=CO2)C(C)C)C1 C=C[C@@H1](CC)CC(=O)NC1(C)CCC(NC(=O)C2=CC(F)=CC(Cl)=C2)CC1 C1C=CSC1CCC(=O)N[C@]23COCC[C@@H1]2CN(C(=O)C45CSC(C4)C5)C3=N CC/C=C/CC(=O)NCC1(NC(=O)C[C@H1](C)C(C)C)CCOCC1 CN(C)S(=O)(=O)C1=CC(NC(=O)[C@@H1]2CC[C@H1]3CC[C@H1]32)=CC=C1Cl CC1=NC=CC(CCCN(N2CCCC3=CC=C(Br)C=C32)CC)=N1 CN1C=NN=C1CCC(=O)N2CC(F)(CNC(=O)[C@]34C[C@@H1]5C[C@@H1]3[C@H1]4[C@H1]5O)C2 CC1=CC(Cl)=CC(C(=O)N(C)[C@H1](C)CNC(=O)C=2C(C(C)C)=N[NH1]C=2C)=C1 CC(C)OCCCCNC(=O)[C@H1]1CCCCC[C@H1]1NC(=O)[C@@H1](O)C=2C=NN(C)C=2 C=C[C@H1](O)C(=O)N1C[C@H1]2CCC[C@H1]2[C@H1]1C(=O)NCC34CC(CCO3)C4 CC=1N=COC=1C(=O)N2CCCC[C@@H1](CNC(=O)C3=CC=CC=C3)C2 C[C@@H1](OC(=O)C(F)(F)C1=CSC=N1)C2=NC=CS2 CN1C=NC(C(=O)N2CC[C@H1](NC(=O)C3=CN=NC(Cl)=C3)C4(CCC4)CC2)=N1 CCOC(=O)C1=CSC(C2=CC=C(CNC(=O)[C@@H1](C)[C@H1]3CCOC3)C=C2)=N1 CCOC1(C(=O)N2CCC(O)(CCNC(=O)[C@@H1]3CC(C(C)C)=NO3)CC2)CCC1 CCN(CCNC(=O)[C@](C)(O)CN1C=CC2=CC=CC=C2C1)C(=O)[C@H1]3CC34CC4 CC(C)O[C@]1(C(=O)N2CC3(CN(C(=O)[C@H1]4CC45CC(F)(F)C5)C3)C2F)CCOC1 CSCC1(C(=O)NCCN(CC2CC2)C(=O)C3=CN=C(C)C=C3Cl)CC1 CN(C[C@@H1]1CCN(C(=O)C2C[C@@H1]3CC[C@H1](C2)N3C)C1)C(=O)C4=CC(O)=CS4 CC(C)(C)C(=O)NCC(=O)N1C[C@@H1]2CN(C(=O)[C@H1]3CCC[C@@H1]3O)CC[C@@H1]21 CC1(C)C(C)(C)C1(F)C(=O)N2CCC3(CC[C@H1]3NC(=O)CCCC#N)CC2 CC1=NC=CC(N2CCOC[C@H1]2CN(C)C(=O)C3=CC(C(C)(C)C)=NN3C)=N1 CN(C)C(=O)CNC(=O)[C@@H1]1CCN(C(=O)[C@H1]2CCNC[C@H1]2OC)C1 CC1=CC(CN2CCN(C(=O)CCC3=CC=CC(Br)=C3F)CC2)=NN1C CC(C)N1C=CN=C1C(=O)N[C@@H1]2CCN(C(=O)C3=NOC(C)(C)C3)C[C@@H1]2O CC[C@H1](CNC(=O)COC(F)(F)F)NC(=O)C=1C=CN(C2=CC(F)=CC=C2F)N=1 CCCCCC[C@@H1](CC)C(=O)N(CC)CCN(CC)C(=O)[C@@H1]1SCCC=2SC=CC=21 C[C@H1]1CN(C(=O)CC(C2CC2)C3CC3)C[C@@H1](C)CN1C(=O)COCC4CC4 CC1=CC(C(=O)N2C[C@H1]3CCN(C(=O)[C@@H1](O)CC(F)(F)F)[C@@H1](C3)C2)=CN=C1O C=CCCC(=O)N1C[C@@H1](F)C[C@H1]1CN(C)C(=O)C=2C=C3N(N=2)CCN(C)C3 CCC1=NC=CN=C1C(=O)N2C[C@@H1](O)C[C@H1](NC(=O)C(Br)=C(C)C)C2 CO[C@](C)(C(=O)N1CC[C@@H1](C)[C@H1](NC(=O)C=2C=NN3C=2CCC3)C1)C4CC4 COCC1=CC=CC=C1C(=O)N2C[C@H1]3[C@@H1](C2)OCCN3C(=O)CC=4C=COC=4 CC1=CC=C(C=CC(=O)N[C@H1]2CCN(C(=O)C3CCC4(CC3)CC(CO)C4)C2)O1 CC(=O)OC(C)(C)C(=O)NCC[C@]1(O)CCCN(C(=O)C#C[C@H1]2CCOC2)C1 O=C(CCC1=CC=C(O)C(O)=C1)NC2CC(CCO)C2 COC[C@@](C)(O)CC(=O)N1[C@H1]2CC[C@H1]1[C@H1](CNC(=O)CCC=3C=C(C)[NH1]N=3)C2 CC1(O)CC(C(=O)N2CCN(C(=O)[C@H1](O)CN3CCCC3)[C@@H1](C=4C=N[NH1]C=4)C2)C1 CC[C@@H1](C)C1=CC=C(C(=O)N[C@@H1]2CN(C(=O)CC3=N[NH1]C(=N)S3)C[C@H1]2OC)C=C1 CN1C=C([C@@H1]2C[C@H1]2C(=O)N[C@H1]3C[C@@H1]3NC(=O)C4=CC=C(Cl)C(N)=C4)C=N1 CC(C)C[C@@H1](O)CC(=O)N1C[C@@H1](C)N(C(=O)C2=COC(CO)=C2)C[C@@H1]1C COC[C@@H1](C)NC(=O)[C@@H1]1[C@H1]2[C@H1]3C[C@H1]1[C@@H1](NC(=O)C=4OC=CC=4COC)[C@@H1]23 COCCN(C(=O)C1(CNC(=O)CN2C[C@H1]3CC[C@H1]2C3)CC1)C4CCCC4 CCN1C=CC(C(=O)N(C)CC2C(NC(=O)C[C@H1]3COC4=CC(O)=CC=C43)C2)=N1 C=CCCCC(=O)N(C)[C@H1]1CCCN(C(=O)C=2C=NN3N=CC=CC=23)C1 CN1[NH1]C=NC1=NC(=O)CC2CN(C(=O)[C@@H1]3CCC(=O)NC3)C2 COC1=CC(C(F)F)=C(C(=O)N[C@H1]2CCN(C(=O)[C@@H1]3CC34CCC4)[C@H1]2C)C=N1 C[C@@H1](C(=O)NCC1CC(N2C=C(CCN3C=NC=N3)N=N2)C1)C4=CC=NC=C4 CO[C@@H1](CNC(=O)CC1(N(C)C)CCC1)C(=O)N2CCC[C@H1]2CC3CC3 CSCCCNC(=O)[C@@H1](C1=NC(C)=CC=C1Br)N2CCOC[C@@H1]2C3CCCC3 CN1CCN(C(=O)C2=CC=C(F)S2)C[C@H1]1CNC(=O)CSC[C@@H1]3CCCCO3 O=C(C#CC1CCCCC1)N[C@@H1]2C[C@@H1]3CN(C(=O)[C@@H1](O)C4CCCCCC4)C[C@H1]32 CC1(OCC(=O)N2CC3(C[C@@H1](CO)CO3)C2)CN(C(=O)C[C@]4(C)CCOC4)C1 CCN(CCNC1=CC=CC=N1)C(=O)OC(C)(C)C CCCC[C@H1](NC(N)=O)C(=O)N1CC(CNC(=O)[C@H1](F)C(F)(F)F)(OC)C1 CC=1N=NSC=1C(=O)NC[C@H1]2N(C(=O)C3=NC=C(F)C=N3)CCC2(C)C C=CCOCC(=O)N(C)[C@H1]1CN(C(=O)C=2OC3=C(C)C=CC=C3C=2C)CC14CC4 C=CCCCCN[C@H1](C1=NN=NN1C2CCCC2)[C@@H1]3CCSC3 CCC1=CC=C(CN(C)C2=NC(=NCC3=NN=CN3CC)[NH1]C=4C=CSC2=4)C=C1 COC(=O)NCC(=O)N[C@]12CCCN(C(=O)C3=CC=CC(=S)N3O)[C@@H1]1C2 CCC(CC)NC(=O)CN1C[C@H1]2C[C@H1](NC(=O)C#CC(C)(C)C)C[C@H1]1C2 CN1[C@H1]2CC[C@H1]1CC(C(=O)N3CCOC[C@H1](CNC(=O)C4=CC=CS4)C3)C2 C[C@@H1]1CCC[C@@]1(NC(=O)CC2=CC=CC=C2O)C(=O)NC[C@@]34CCC[C@@H1](CO3)C4 C[C@@H1]1C[C@H1](CO)N1C(=O)C[C@@H1](NC(=O)C(C)(C)CN(C)C)C(F)F CC(=O)NCCC1=CN(C[C@@H1](C)NC(=O)CCC2=CC=C3C(=C2)COCC3)N=N1 CC1=NC=C(Cl)C=C1CC(=O)N[C@H1](CNC(=O)C(F)(F)C(F)F)C2=CC=CC=C2 NC(=O)C1=CC=CC=C1C(=O)N2C[C@@H1]3C[C@]3(CNC(=O)[C@@H1]4CCC45CCC5)C2 CCN(CC)C[C@@H1](F)C(=O)N[C@@H1]1C[C@H1]1NC(=O)C2=CC=C(Cl)C(C)=C2Cl CCOC(=O)C1(O)CCN(C(=O)[C@@H1]2CNC(=O)C[C@@H1]2C3=CC=C(Cl)C=C3)CC1 NC(=O)CCNC(=O)C(=O)N[C@@H1](CNC(=O)[C@]1(O)CCOC1)C2CCCC2 C=CC(C)(C)CC(=O)N1CCC(O)(C(=O)NCC(=O)C=2C=NN(C(C)C)N=2)CC1 CC(C)C(C)(C)NC(=O)[C@@]1(F)CCN(CS(=O)(=O)C2=CC=CC(C#N)=C2)C1 CC1(CNC(=O)CC2(C3=CC=C([N+1](=O)[O-1])C=C3)CCCC2)C[C@@H1]4C[C@H1]4C1 CCC1CC(CC(=O)N[C@H1]2C[C@H1](CCNC(=O)C=3C=C(C(N)=O)[NH1]N=3)C2)C1 C=CC=CCC(=O)NC[C@H1](NC(=O)CC1=CC=CC=C1SC)C(C)C C#CC[C@@]1(C(=O)NCCC[C@@H1](C)NC(=O)C2=NN(CC)C=C2Cl)CCOC1 CN1N=C(Cl)C=C1C(=O)N2CC[C@H1](NC(=O)COCCCF)C(F)(F)CC2 CC[C@H1](CCC(=O)NCC1[C@H1]2CN(C(=O)C=3C=NN(C(C)C)C=3C)C[C@H1]12)OC CC(C)C[C@H1](ONC(=O)C1=CN=CN=C1)C(=O)N(C)CCC[C@@H1](O)CO C[C@H1](F)CC(=O)NC[C@](C)(CO)NC(=O)C1=CC2=NC(F)=CC=C2O1 COC1=CC(F)=CC=C1C(=O)N[C@@H1]2CN(C(=O)[C@H1]3CC=C(C)CC3)CC4(CC4)C2 O=C(C1=CC(C2=CCCC2)=C(F)C(O)=C1)N3CCN(C4=C(F)C=CC=C4Cl)CC3 CN1C=C(CC(=O)NC2(CO)CN(C(=O)C3=CC=C4C=COC4=C3)C2)N=N1 CCS(=O)(=O)NCCC(=O)N[C@@H1]1CN(C(=O)C2=CN(C)C(C)=CC2=O)C[C@@H1]1C C[C@H1]1CN(C(=O)COC2=CC=C(F)N=C2)CCN(C(=O)C3=CN=C(O)O3)C1 CCOC(=O)[C@H1](OC)C(=O)N[C@@H1]1CN(C(=O)CC[C@H1]2CCCCO2)[C@@H1]3CCC[C@@H1]13 CC(=O)N1CCC[C@@H1]1C(=O)OCCC2=CC=CC=N2 CSC1=NN(C)C=C1C(=O)N2CCC([C@H1]3CCCN(C(=O)C4(F)CC4)C3)CC2 COCC1(C(=O)N[C@@H1]2C[C@H1]3C[C@H1]2CN3C(=O)CC4(C(F)F)CC4)CCOCC1 N=C1C=CC(C=CC(=O)N2C[C@H1]3C(CNC(=O)C(C4CC4)C5CC5)[C@@H1]3C2)=C[NH1]1 CC1=C[NH1]N=C1C(=O)N2CCO[C@@H1]([C@@H1](C)NC(=O)C=3OC=CC=3Cl)C2 CC[C@@H1](O)[C@H1](C)C(=O)NC12CC(C1)N(C(=O)C3(S(C)(=O)=O)CCCCC3)C2 C=CCC(=O)N[C@H1]1CCC12CCN(C(=O)[C@](O)(C=3C=N[NH1]C=3)C(F)(F)F)CC2 C#CCC1(NC(=O)[C@H1]2C[C@@H1](N=[N+1]=[N-1])CN2C(=O)[C@@H1]3[C@@H1]4CC[C@@H1](F)[C@@H1]43)CCC1 CC1=NSC=C1C(=O)N2CC[C@@]2(C)CC(=O)N3CCC[C@H1](C4(C)CC4)C3 C[C@@]1(CNC(=O)CCC=2C=COC=2)CC[C@@H1](NC(=O)C=3SC=NC=3C4CC4)C1 O=C(C1=CC=NS1)N2CC3(C2)CN(C(=O)C4=CN=C([C@H1]5CCOC5)S4)C3 COC1([C@H1](C)NC(=O)[C@H1](F)C2CC(NC(=O)C[C@@H1]3CCCOC3)C2)CCC1 CC(C)(CC(=O)NC1CC2(CC(N)C2)C1)C(F)F CC1=NOC=C1C2=NO[C@]3(CCCN(C(=O)C4=CC=CN=C4CC(C)C)C3)C2 O=C(C1=CC(Br)=CO1)N2CC3(CC3)C4=CC=CC=C42 O=C(N[C@H1]1CCN(C(=O)/C(F)=C/C2=CC=CC(F)=C2)C[C@H1]1O)C3=CN=N[NH1]3 C=C(C)CN1N=NN=C1[C@@H1](CC[C@@H1](C)OC)NCCCN2C=CC=N2 CC[C@@H1](C(=O)NC1CC2(C1)C[C@@H1]2NC(=O)C3=CN=CN=C3C4CC4)C(=O)OC CON(CCCO)C(=O)[C@H1](NC(=O)[C@H1](O)CSC)C1=CC=CO1 C[C@H1](NC(=O)C=1C=C2N(N=1)C[C@H1](F)C2)C3(O)CCN(C(=O)C(C)(C)C(C)(C)C)CC3 CN(C(=O)C1CC2(CC(F)C2)C1)C3CN(C(=O)C4=CC(C5(C)CC5)=N[NH1]4)C3 CC=1N=C(C(=O)N[C@@H1]2CCC[C@H1]2NC(=O)C(F)=C3CCC(F)(F)CC3)N(C)N=1 O=C(C1=CC=2C=CSC=2[NH1]1)N3CC(F)(C(=O)N4CCC[C@@H1](CO)C4)C3 CO[C@H1]1CN(C(=O)CC2CC(C3CC3)C2)[C@@](C)(CNC(=O)C4=CC=CC=N4)C1 CC(C)C1=CC=C([C@@H1](CNC(=O)[C@H1](C)O)NC(=O)CC2=CC=C(F)C(Cl)=C2)C=C1 CCC1=CC=C(C(=O)NC2(CNC(=O)C3(C)CCSCC3)CCCCC2)N=C1 C=C[C@H1](CC(=O)N1CC[C@@H1]2C[C@@]2(NC(=O)CP(C)(C)=O)CC1)C3=CC=CC=C3 C[C@H1]1[C@@H1](NC(=O)CC[C@H1]2CCCCN2C)CCN1C(=O)CC(C)(C)C3CCCC3 C[C@@]1(C(=O)NC2CCC(NC(=O)COCC(F)(F)F)CC2)CC(C3CC3)=NO1 CC1=CSC([C@H1](N[C@H1]2CCC3=CC=CC=C32)C4=NN=NN4C5=CC=C(F)C=C5)=C1 CCC[C@@H1](C)C(=O)N1CCCC[C@H1]1CCN(C)C(=O)C=2N=NN(C3CC3)C=2C(F)F CN1N=CC(C2CC2)=C1C(=O)N3C[C@H1]4[C@@H1](NC(=O)[C@H1]5C[C@](F)(CO)C5)C[C@H1]4C3 C#CCNC(=O)CC(=O)N1[C@H1]2CC[C@@H1]1C[C@@H1](CNC3=C(Cl)C=CC=C3[N+1](=O)[O-1])C2 C=C[C@](C)(CC)C(=O)N1CCN(C(=O)C=2C=NN(CC)C=2)CC13CC3 C[C@@H1](C(=O)O)N(CCF)C(=O)CCNC(=O)[C@@H1]1CCCCO1 C=CCCCCC(=O)N[C@H1]1CCN(C(=O)[C@@H1](NC(=O)C2=CC=CS2)C(C)C)[C@@H1]1C CCOC(=O)[C@H1](C(=O)N1CCN(C(=O)C2=CCCCC2)C[C@@H1]1CF)C(C)(C)C C[C@H1]1CNC[C@@H1]1C2=CC=C(C(C)(C)O)C=C2 CC[C@H1](OC1=CC=CC=C1)C(=O)N[C@@H1]2CC[C@H1](CNC(=O)C(C)(C)CC(F)F)C2 CC1=CC=CC2=NC(C(=O)N(CCNC(=O)C3=CC(Cl)=C(Cl)S3)C4CC4)=CN12 CC1=NOC(Cl)=C1CCC(=O)NC2(C)CN(C(=O)[C@H1](C)C3=CN=CS3)C2 C[C@@H1]1[C@H1](C(=O)N(C)[C@@H1]2CN(C(=O)C3=CN(C)N=C3C(C)(C)C)CC[C@@H1]2O)[C@@H1]1C O=C(N[C@H1]1CN(C(=O)C=2C=NC3=C[NH1]N=C3C=2)CC[C@@H1]1CO)C(C4CC4)C5CC5 CC=1[NH1]C=CC=1C(=O)N2CCC[C@]2(C)C(=O)NCCCCCF C[C@]1(CNC(=O)[C@@H1](NC(=O)C=2N=C[NH1]N=2)C3(O)CCC3)C=CCCC1 O=C1NC2=CC(Br)=CN=C2NC(=O)[C@H1]1CC3CCCC3 COC(C)(C)C1=NOC(COC(=O)CSC2=CC(Br)=CC=C2C)=N1 C=CC1(NC(=O)NCC(C(=O)OC)CCC)CCOCC1 C[C@@H1](CC(F)F)C(=O)NC[C@@H1](CO)NC(=O)CC1=CC=NC(Cl)=C1F CS[C@@H1](C)CC(=O)NCC1=CC=NC(C(=O)N[C@@H1]2[C@H1]3CCC[C@H1]32)=C1 C=CC[C@](C)(O)C(=O)NCC(C)(C)OCC(=O)N[C@H1](C)C1=CN=CS1 CC1=NC=NC=C1C(=O)N(C)[C@@H1]2CN(C(=O)[C@H1]3C[C@H1](O)C3)CC[C@@H1]2O CC1=CC=C2C(=C1)CN(C(=O)[C@@H1]3CC4(CC4)CN3C(=O)C5=CN=C(Cl)N=C5)CC2 CC1=CSC(C(=O)N2CC(F)(F)C[C@]2(C)CNC(=O)CCN3C=CC=N3)=C1Cl CC1=C(F)C=CC([C@H1](C)NC(=O)NCC2=NC(C(C)(C)C)=CS2)=C1F CC=1[NH1]N=C(C(F)(F)F)C=1C(=O)N2CC(F)(CNC(=O)[C@H1](C(C)C)N(C)C)C2 C#CCNC(=O)CC(=O)NCC(=O)N[C@H1]1CC[C@@H1]1N(C)C CC1(C)O[C@H1]2C[C@@H1](C(=O)N[C@@H1](CCNC(=O)C[C@@H1]3COC[C@H1]3O)C(C)C)C[C@H1]2O1 CCC(CC)CCCC(=O)N(C)[C@@H1]1CCN(C(=O)[C@@H1](F)CC2=CC=CC=C2)C1 CC[C@H1](C)[C@H1](C(=O)N[C@H1]1[C@@H1]2C[C@H1]1N(C(=O)CCNC(C)=O)[C@@H1]2C)N(C)C CC1=CC=CN(CC(=O)N[C@H1]2CCCC23CN(C(=O)C4=NC=CN=C4N)C3)C1=O CC1=NC(C(=O)N[C@H1]2CN(C(=O)[C@@H1](O)P(C)(C)=O)CC23CCC3)=CO1 CC(C)[C@H1](O)CC(=O)N1CC(C)(C)C[C@@H1]1CNC(=O)C2=CC=NC=C2 O=C(C=1N=CN2C=1CN(C(=O)CC3=NC(Cl)=CS3)CC2)NC4=CC(Br)=CC(Cl)=N4 CCCN(C)CC(=O)N1CCC[C@@H1](CCNC(=O)C2=C[NH1]N=C2C=3C=NN(CC)C=3)C1 COCCOCCNC(=O)[C@]1(CNC(=O)C2=CSC(=N)[NH1]2)CCCO1 C#CC(=O)N[C@H1](CC1=CC=C(O)C=C1)C(=O)N2CC[C@@H1](O)[C@H1]2C(=O)NC[C@@H1](C)O CC=CC(=O)NC[C@H1](C)NC(=O)[C@@H1]1CCC=2N=NN(C)C=2C1 C=CCCC(C)(C)C(=O)N1CC[C@@](C)(NC(=O)COCCC2=CC=CS2)C1 CC1(C)CCC(C)(C(=O)NCC2(CNC(=O)C3=COCC3)CC2)CC1 O=C(C[C@H1]1CNC2=CC=CC=C21)N3CC[C@H1](N4C=C(C5=CC=C(O)C=C5)N=N4)C3 CCOC[C@H1](NC(=O)C[C@H1]1COC[C@H1](C)O1)C(=O)N(C)CC2(O)CCCCC2 CC(F)(F)C1=CC=C(C2=NC=CC=C2C(=O)NCC3CCC3)C=C1 C[C@@H1](NC(=O)C1C(C)(C)C1(C)C)[C@@H1](CO)NC(=O)C2=CC=C3C=C[NH1]C3=C2 O=C(CCCC1=CN=CC=N1)N2CCC3(CCN(C(=O)C4=CSC(O)=N4)C3)CC2 O=C(CN1CCCCC1=O)N2C[C@@H1]3C[C@H1](C2)CN3C(=O)C[C@@H1]4NC(=O)CNC4=O CC1=CC=CC=C1COCC(=O)N2CC(O)(CCNC(=O)[C@@H1]3CCC3(C)C)C2 CC1=CN=C(C(=O)NC2=NC=C(C=3C=NN(C(C)(C)C)C=3)C(C)=N2)C=N1 CCC1=NC(C(=O)N2CC[C@H1](NC(=O)CO[C@@H1]3CC3(F)F)C2)=CS1 CCOC(=O)CC(=O)N1C[C@H1](CCNC(=O)C(=O)NCC(F)F)O[C@H1](C)C1 CC(C)C[C@H1](C)NC(=O)C1(CCNC(=O)C[C@H1]2C=CCC2)CCC1 O=C(C1=CC=C(CO)C=C1F)N2CC3(CCN(CC4=CN=CC(O)=C4)CC3)C2 O=C(CCC1CCCCC1)N[C@@H1](CNC(=O)C2(N3CCOCC3)CC2)C4CCC4 CN(C)C[C@@H1](CC(=O)NC/C=C/CNC(=O)[C@@H1]1[C@H1](C(F)F)C1(C)C)C(F)F CCCC1=NC2=CC(C(=O)N3CCN(C(=O)C4=CCC4)C[C@@H1]3CF)=CC(C)=C2[NH1]1 CC[C@H1](NC(=O)C1=CC=CO1)C(=O)N[C@@H1]2C[C@@H1]2NC(=O)C3=CSC=C3Br CCC(CC)C(=O)N[C@H1]1CCN(C(=O)CC2CCN(S(C)(=O)=O)CC2)C13CC3 C=CC[C@H1](CNC(=O)C1=CC=C(OCCC)C=C1)NC(=O)[C@H1](COC)OC CSC[C@H1](C)C(=O)N[C@H1](CNC(=O)CC=1N=C2N=CC=CN2N=1)C(C)(C)C CC1=CC(C(=O)NC2CC(N(C)C(=O)/C(Cl)=C/Cl)C2)=CC=C1C(F)(F)F C=CCC1(NC(=O)[C@H1](C)O)CN(C(=O)C(F)(F)[C@H1](C)O)C1 CC[C@]1(C(=O)N2CC(CO)(NC(=O)C3=CC(O)=NC(OC)=N3)C2)CCCCO1 COCC[C@@H1](C)C(=O)NCC(=O)NC1CN(C)CCN(C)C1 CN1N=CC=2C=C(C(=O)N3CC(CCCCNC(=O)C4=CN=CN=C4)C3)SC=21 CCC1=CSC=C1C(=O)N2CC3(C=C(C(=O)NCCCCSC)CO3)C2 CCC[C@@H1](CCCS(C)(=O)=O)C(=O)NC1=C(C)C=NN1C(C)C CO[C@H1](C)CCC(=O)N1C[C@@H1](F)C[C@H1]1CNC(=O)CC=2C=NN(C(F)F)C=2 COC1=NC=NC(C)=C1C(=O)NC[C@@H1]2[C@H1](CNC(=O)C=3SC=C(C)C=3Cl)C2(F)F C=CCSCC(=O)N1CCCC(C)(C)[C@H1]1CNC(=O)C=2SC(C)=NC=2C COC[C@@]1(C(=O)NC[C@]2(F)C[C@@H1](NC(=O)[C@@]3(C)CCCC3(F)F)C2)CC1(F)F O=C(C[C@H1](CN=C1C=CN=C(Br)[NH1]1)C2CC2)N(CCO)CCN3CCOCC3 CCN1N=C2C(=C1C(=O)N3C[C@H1]4C[C@@]4(NC(=O)[C@@H1](C)CC(F)F)C3)CCCC2 CC1(NC(=O)C[C@@]2(O)CCCN(C)C2)CCN(C(=O)CCCCC(F)(F)F)CC1 CCN1CCC(C(=O)NC2CC([C@H1](F)C(=O)N3C[C@H1](OC)[C@H1](OC)C3)C2)CC1 CC(C)(F)CNC(=NCCCC1CCCCC1)NC[C@@H1]2C(F)(F)C23CC3 CN(C)C(=O)C(=O)N1CCC2(CC1)[C@H1](NC(=O)[C@H1](O)CC3=CN=C[NH1]3)CS2(=O)=O O=C(CC1=CC=C(O)C=C1Cl)N[C@@H1](CO)CNC(=O)C2=CSC3=CC=CN=C23 CN(C(=O)[C@H1]1CCC2=NC(=N)[NH1]C=C2C1)C3CN(C(=O)[C@H1]4C[C@@H1]5C[C@@H1]5C4)C3 C[C@@H1]1CCN(C(=O)C2=CC=CC(O)=C2Cl)[C@H1](C)[C@@H1]1NC(=O)C=3C=NN(CCF)C=3 C[C@@H1](CN[C@H1](CCC1=CC=NC=C1)C(N)=O)C2=C(Cl)C=CC=C2Cl COC[C@H1](O)CN(C)C(=O)[C@H1]1CCCN1C(=O)C2=COC(C)=N2 CCC1=NN(C)C(CC)=C1[C@H1]2NC(=O)N(CC)[C@H1]2C3=CC=CC=C3OC CC1=NC(C(=O)N2C[C@H1]3C[C@]3(CNC(=O)CCN4C=CC=N4)C2)=C(C)N1C C=C(C)[C@@H1]1OCC[C@@H1]1C(=O)N2CCC[C@@H1](C3(NC(=O)C4=CSC(COC)=N4)CC3)C2 CCC1CC([C@H1](C(=O)NC2CC2)N3CCNC(=O)C34CCCCC4)C1 O=C(NC1(C(F)F)CCNCC1)C2=C[NH1]N=C2[C@@H1]3CCOC3 C=C=CCC(=O)N[C@H1]1C[C@H1](F)CN(C(=O)C2=N[NH1]C3=C2CCOC3)C1 CCN(CCOCCO)C(=O)[C@H1](NC(=O)C=C[C@@H1]1CCCN1C)C(C)(C)C CCOC(=O)[C@@H1](F)C(=O)N(C)CCCNC(=O)[C@@H1](CSC)C1=CC=CC=C1 C[C@H1](CC1=NC(C2=CC=CC(N(C)C)=N2)=NN1CC)C3=CC=NC=C3 CCOC=1C=C(C(=O)N(C)CC2(O)CN(C(=O)C3CCC34CCOCC4)C2)ON=1 CN1CCC[C@@H1](C(=O)NC2CC([C@H1]3CCN(C(=O)C4=CC=NN=C4)C3)C2)C1 CC=1C=NOC=1C(=O)N2CC[C@@](CF)(NC(=O)C[C@@H1]3OCC[C@@H1]3C)C2 C[C@H1](CC(=O)N[C@@H1]1COC2(C1)CN(C(=O)C3=CN(C4CCC4)N=N3)C2)N(C)C CC1=NC(C2=CC=CC(N3CCCC3)=C2)=CC=C1C(=O)NCCOC4CCCC4 COCCNC(=O)CN=C1[NH1]C(=NC[C@H1](C)CC(=O)OC)C2=CC=CC(F)=C2[NH1]1 CCC[C@](C)(O)CC(=O)NCC1(CC(=O)N[C@@H1](C)C2=NC(=O)O[NH1]2)CC1 COC1=CC(C#N)=CC=C1C2=NC(C)=C(NC3=NC=NC4=C3C=NN4C(C)C)S2 COCC[C@@H1]1CN(C(=O)C(C)(C)SC)CCN1C(=O)[C@@H1](O)CSC CNC(=O)N[C@@H1](C)C(=O)N1[C@H1](C)[C@H1]2C[C@@H1]1[C@H1]2NC(=O)C(C)(C)CC(C)C CC(C)OC(=O)C1=CC=CN=C1N2C[C@H1]3[C@@H1](NC(=O)C4=CC=CN=C4)C[C@H1]3C2 CCCC[C@H1](O)CC(=O)N1C[C@H1](C)[C@@H1](C(=O)NCCNS(=O)(=O)CC)C1 C=C(F)C1(CC(=O)N[C@@H1](C)[C@@H1](NC(=O)C2=CC(O)=CC=C2Cl)C(C)C)CCC1 C[C@]1(CNC(=O)C[C@@H1]2CCCOC2)CN(C(=O)[C@]34CC[C@H1](C[C@H1]3O)C4)CCO1 CO[C@@H1]1C[C@H1]1C(=O)NC[C@@H1]2CCN2C(=O)C3=CN=C(C#N)C(F)=C3 CCOCCN1C=C(CCCC(=O)N[C@@H1](CCO)C2=CC=C(C(C)C)C=C2)N=N1 C[C@@H1]1C[C@H1](C(=O)O)CCN1C(=O)NC[C@@H1]2CCOCC23CCCC3 CC1=NC=CC(C(=O)N2C[C@H1]3C[C@H1]2CN(C(=O)CN(C)[C@@H1]4CCSC4)C3)=N1 C#CCCN(C)CC(=O)NCCCC(=O)NCCN1C[C@H1]2C[C@@H1]2C1 O=C(NC[C@]1(C(=O)N2CC[C@H1](O)C2)CC13CCC3)C4=CC=NC(CO)=C4 CC=C(C=CC(=O)N1CCC(O)(CN(C)C(=O)[C@]2(CC)CCCO2)CC1)CC CC1=CC(Br)=C(F)C(C(=O)NC2CCN(S(=O)(=O)C(F)(F)F)CC2)=C1 CNC(=O)COCC(=O)N[C@H1]1C2C[C@H1]3[C@@H1](C2)C13C(=O)N(C)[C@H1](C)C4CCOCC4 COC1=CC=C2C(=C1)OC[C@@H1]2CC(=O)NC[C@H1](NC(=O)CCCC(C)=O)C3CC3 N#CC1(CC(=O)OCC2=NN=C(C3CCOCC3)O2)CCCCC1 CC(=O)N1CSC[C@@H1]1C(=O)N2CCN(C(=O)[C@H1](C)N(C)C(C)=O)C[C@@H1]2CCO CCCC1=NC=C(C(=O)NC[C@@H1]2CC(F)(F)CN2C(=O)CC3CC4(CC4)C3)S1 CO[C@@H1](CC(C)C)C(=O)N(CCNC(=O)[C@H1]1C[C@@](F)(CO)C1)C2CC2 CC1=CC=CC(F)=C1C(=O)N2CC[C@]3(CO[C@H1](CNC(=O)C=4N=COC=4C)C3)C2 C[C@H1]1CN(C(=O)CN2CCOCC2)C[C@@H1]1C3=CC=CC=C3 CC[C@@H1]1CC[C@@](O)(C(=O)NC[C@@]2(F)CC[C@H1](NC(=O)C3=CN=CN=C3CC)C2)C1 CC[C@H1]1CCN(C(=O)[C@H1](C#N)C(C)(C)C)[C@@H1](C(=O)N2CCO[C@H1](CF)C2)C1 CC=C1CN(C(=O)[C@@H1]2COC3(C2)CN(C(=O)CC4(C)CCCCC4)C3)C1 COC[C@H1](OC)C(=O)N(CCNC(=O)C=C[S@](C)=O)CCC1=CC=CC=C1 COC1(CCNC(=O)C2=CC=NS2)CN(C(=O)CC=3C=C(C)[NH1]N=3)C1 CC1=CC=C(C(=O)NC[C@H1]2CN(C(=O)C3=COC(C(F)F)=C3)CC24CC4)C(N)=N1 CC1=CN=C(C=CC(=O)N2C[C@@H1](N=C3N=CN=C4[NH1][NH1]C(C)=C34)C5(CCC5)C2)[NH1]1 CC(C)(C)OC(=O)N[C@@H1]1CCC[C@]1(O)CN2CCN(CCCF)CC2 CCN(CC[C@H1](C)F)[C@@H1](C1=CC=C(Cl)C=C1)C2=CC=CC=N2 C=C[C@@](C)(CCOC)C(=O)N(C)CC[C@@H1](NC(=O)C=1C=C(Cl)ON=1)C(C)C O=C(N[C@@H1]1C=C(C2=CC=CC=C2)C1)C3=CC=C(CC4CCC4)C=C3 C[C@H1]1CCCCN1CC(=O)N2CC[C@@H1]2CC(=O)N(C)CCC=3C=NN(C)C=3 CCC1=C(C(=O)N(C)[C@H1]2[C@@H1]3CN(C(=O)C4CC(C5CCCC5)C4)C[C@@H1]32)SCCO1 CCC[C@@H1](CC)C(=O)NCCOCCN(C)C(=O)C1CC2(C1)CC3(CCC3)C2 CC1(C)[C@H1](C2=CC=CC=C2)[C@@H1]1NC(=O)NCC3=NC=CN3C4=CC=CC=C4 CC(C)N(CCN(C)C(=O)CCC(=O)C1CC1)C(=O)CC2=CC=C(F)C(Cl)=C2F CCC1=CN2C(C(=O)N3CC(C)(NC(=O)C[C@@H1](C)CC(C)C)C3)=CC=CC2=N1 CN(CC(=O)N[C@H1]1CCN2C=NN=C2C1)C(=O)C3=CC=C(C4CC4)C=C3 C=CC1(CC(=O)N(C)[C@@H1](C)CN(C)C(=O)C2=NC(C)=CC=C2O)CCOCC1 C[C@@H1]1[C@@H1](NC(=O)C2=CC([N+1](=O)[O-1])=CN2C)C[C@H1]3CC[C@H1]1N3C(=O)[C@H1]4CCC[C@H1]4O CN(C)CCC1(C(=O)N2CCC[C@](CO)(NC(=O)C3=CC=C(F)O3)C2)CC1 C=C=C[C@H1](C)C(=O)N1CC[C@@](C=C)(C(=O)NCCC2=NC=CN2C)C1 O=C(NCC(F)F)[C@H1](C1=CC=C(OC2CC2)C=C1)N3CCO[C@H1](C[C@H1]4CCCO4)C3 CC=1N=N[NH1]C=1C(=O)NC[C@@H1](CNC(=O)C2=CC=C3C(=C2)[C@H1](C)CN3)C(F)(F)F CCC1=C[NH1]N=C1C(=O)N[C@@H1]2C[C@@H1]3CC[C@H1](C2)N3C(=O)C4(F)CCCCC4 CCN(C(=O)CCC1=CC=CO1)C2CCN(C(=O)C3=CC=CC(N)=N3)CC2 CC1=CC=C(NC(=O)C(=O)N2CCO[C@@](C)(CNC(=O)C=3C=COC=3)C2)C=C1C CN(CC(=O)NCCCCCN(C)C(=O)[C@@H1]1OCCOC1(C)C)C2=CC=CC=C2 O=C(COCC(F)F)NC1(CNC(=O)C2(C3=CC=CC=C3)CC4(CCC4)C2)CC1 CC=CCC(=O)N1CCC[C@H1](C)[C@H1]1CNC(=O)C2=COC(C=3C=NN(C)C=3)=N2 COCC=1N=CSC=1C(=O)N2CC(N(C)C(=O)C=CC=3C=C[NH1]N=3)C2 O=C(C1=CC=CC=C1N2C=CC=C2)N(C3=NC=NN4C=CC=C34)[C@@H1]5CNC[C@@H1]5F CCCC[C@H1](O)C(=O)N1CCN(C(=O)CN2C=CC=C2)C[C@H1](O)C1 O=C(NC1=CC=C(F)C=C1O)[C@@H1](F)C2=CC=CC=C2Br CC[C@H1](F)C(=O)N1C[C@@H1](O)[C@H1](N(C)C(=O)C2=CN=C(C(F)F)S2)C1 O=C(C1=N[NH1]C2=C1CSCC2)N3C[C@H1]4CC[C@H1](NC(=O)C56CC(CO)(C5)C6)[C@H1]4C3 CC1(C)CN(C(=O)C23CCC(CC2)CO3)CC[C@H1]1C(=O)NC[C@H1]4CCSC4 C[C@H1]1CC[C@H1](C(=O)N2CCN(C(=O)CCC3=NN=CN=C3O)CC4(CC4)C2)C1 N#CC1=NC=C(Br)C=C1NC(=O)[C@H1]2CCCC[C@@H1]2NCC3=CC=C(O)N=C3 O=C(CCC=1C=NOC=1)N[C@H1](CC(F)F)C(=O)N[C@H1](CCO)C2CCCC2 CCOC(CC(=O)NCC12CC(CN1C(=O)[C@H1]3CCC[C@H1]3O)C2)OCC CCN(CCNC(=O)C1=C[NH1]C(=N)N=C1C(F)(F)F)C(=O)COC2CCC2 C[C@@H1](NC(=O)OC(C)(C)C)C(C)(C)C(=O)N1CCC2(CC1)CNC(=O)[C@@H1]2O CC(=O)CCCC(=O)NC[C@@]1(C)CCN(C(=O)CCC2CCCCCC2)C1 O=C(N[C@@H1]1CC12CCN(C(=O)CC[C@H1]3CCCOC3)CC2)[C@@H1]4C[C@@H1]5C=C[C@H1]4C5 CCC[C@H1](C)[C@@H1](CO)NC(=O)CC1CCN(C(=O)C2(Cl)CC2)CC1 CCCN(C(=O)[C@H1](C)NCC=1C=NN([C@@H1]2CC2(F)F)C=1)C(=O)COC(C)(C)CC O=C(CN1CCS(=O)CC1)N[C@H1]2C[C@H1](O)CN(C(=O)CCN3C=CC=N3)C2 CN1CC2(C1)[C@H1](C(=O)NC[C@H1]3C[C@](F)(CNC(=O)C=CCO)C3)CCS2(=O)=O C=C(C)C[C@@H1](NC(=O)C=1C=NSN=1)C(=O)N2CCC(F)(CF)CC2 C=CCSCC(=O)N1CCN([C@@H1](CNC(=O)[C@H1](F)C(C)C)C(F)F)CC1 CN(CC1=CC(Br)=CC(OC(F)(F)F)=C1)C(=O)C(=O)NC2CNC(CF)C2 CCCC=CC(=O)NCCOC1CN(C(=O)C2=CC=C3C(=C2)C[C@H1](C)O3)C1 CC[C@H1]1CCN(C(=O)COC2CCC2)[C@H1]1C(=O)NCCOCCC(C)C CC[C@@H1]1CCN(C(=O)C2=CC=NC=N2)[C@H1]1C(=O)NC3(C=4N=N[NH1]N=4)CC3 CC1=CC(CC(=O)NC[C@@]2(C)CCCN(C(=O)C=3C=CC(=O)N(C)C=3)C2)=NO1 CC1=CN=CC=C1C[C@H1](C)N=C2[NH1]C(=NCC[C@H1](O)C3CC3)C4=CC=CC=C4[NH1]2 CC=1C=CN([C@@H1](C)C(=O)N2CCOC[C@H1](NC(=O)C3=CN=CC(C)=C3Cl)C2)N=1 CC(=O)C1=C[NH1]C(C(=O)NC[C@@H1](CNC(=O)C=2N=CN(C)N=2)C(F)(F)F)=C1 CC1=NC(C(=O)NC2(CN(C)C(=O)CCNC(=O)NC3CCCCC3)CC2)=CO1 CC(C)C[C@@H1](C(N)=O)N(C)C(=O)CC1(N(C)C(=O)C2=CC=CN2C(C)C)CC1 COC1=CC=C(OCCCC(=O)N2CC(CO)(NC(=O)C3=CC=C[NH1]3)C2)C=C1 O=C(N[C@@H1]1COC[C@H1]1CNC(=O)C2CC(C3CCC3)C2)C4=NC=C(Cl)C=C4O COC[C@H1](C)CC(=O)N[C@@H1]1CN(C(=O)C2CC(C)(F)C2)[C@H1]3CCC[C@@H1]13 C#CC1=C[NH1]N=C1C(=O)N2CC(C3CCN(C(=O)CCC[C@@H1](C)CC)CC3)C2 CCC=1OC=C(C)C=1C(=O)N[C@@H1]2C[C@@H1]3CN(C(=O)[C@H1](C#N)C(C)C)C[C@H1]32 CO[C@@H1](C)C(=O)NC[C@@](C)(CO)NC(=O)CC1=CSC(C2=CC=CC=C2)=N1 C[C@H1](NC(=O)C=1C=C2N(N=1)CCNC2)C=3C=NN(CC4CCC4)C=3 CCCN1C=C(CN2C[C@H1](F)C[C@@H1](C(=O)NC3=CC(Br)=C(F)C=C3C)C2)C=N1 CCN1C(=O)C(=O)[NH1]C(=NCCCCNC(=O)C2=CC(Cl)=CC=N2)C1C CCCC[C@@H1](CNC(=O)C1=CC=C(F)C(N)=C1)NC(=O)[C@H1](CC(C)C)C(N)=O CC(C)(C)C1=NO[C@H1](C(=O)N[C@@H1]2[C@H1]3C[C@@H1]2N(C(=O)CN4C(=O)CNC4=O)C3)C1 C[C@H1](NC(=O)CC1=CC=CC=C1)C(=O)N2CC(NC(=O)CCCCC(F)F)C2 C[C@@H1](C(=O)NC1(CO)CCN(C(=O)CC2=NC([N+1](=O)[O-1])=N[NH1]2)CC1)C3CC3 CCC=CC=CC(=O)NC[C@H1]1CCCN(C(=O)[C@H1](C)CC2=CC=CC=C2C)C1 CC1CC(C(=O)N[C@@H1]2[C@H1]3C[C@@H1]4CN(C(=O)CCN5C=CC=NC5=O)[C@@H1]2[C@H1]4C3=O)C1 O=C(N[C@H1]1C=CCN(C(=O)C2=CC(O)=CC(O)=N2)C1)[C@@H1]3CCCSC3 CN1CCC[C@@H1]1C(=O)N2CCC3=CC=CC=C3[C@@H1](NC(=O)C[C@@H1]4COCCO4)C2 CC1=CC=CC(CNC(=NCCCF)N[C@@H1]2C[C@](C)(OC)C23CCCC3)=C1 CC1=NC(C=CC(=O)N[C@@H1]2CN(C(=O)[C@H1]3OC[C@H1]4CCCC[C@H1]43)C[C@H1]2O)=CS1 COC1=CC=C(C)C(C(=O)N2CCC[C@@H1](CNC(=O)C(C)(C)CC(F)F)C2)=N1 CCOC1=NC(C(=O)N[C@@H1]2C[C@H1]3CC[C@@H1]2N3C(=O)CNC(=O)C4CCC4)=CO1 O=C(C1=CC=CC2=NC=CC=C12)N3CCN(C(=O)C4=N[NH1]C=C4Cl)[C@H1](C5CC5)C3 CCC[C@H1](O)CC(=O)N[C@H1]1C[C@@](F)(CNC(=O)C2=N[NH1]C3=C2CCC3)C1 C[C@@H1](COC1=CC=C(F)C=C1Cl)NCCN2CCC(C(N)=O)CC2 CC1=CN=C(CC(=O)N2C[C@@H1]3C[C@]3(CNC(=O)[C@@H1](C)CC(C)(F)F)C2)O1 CCC[C@H1](C)N1C[C@@H1](C(=O)NCCCNC(=O)C2=CC=C(F)C=C2C#N)CC1=O CN(CC(=O)N1CC(CS(N)(=O)=O)C1)C(=O)[C@H1](O)C(F)(F)F CCCC(=O)N1CC2(CCN(C(=O)[C@H1](CC3=CC=CC=C3)C(C)C)CC2)C[C@H1]1C CC1=CC=C(C(=O)N2C[C@@H1](CNC(=O)C3(CO)CCC3)O[C@H1]4CCC[C@@H1]42)C(O)=N1 CCO[C@H1](C(=O)N(C)CC1CCN(C(=O)C2(CO)CC(F)(F)C2)CC1)C3CCC3 CCN(CC)CCCCNC(=O)CCCN(C)C(=O)[C@@H1](C)N1CCCCC1 CN1C=CC(C(=O)N2C[C@@H1](CC(=O)N3CCN(C4CC4)CC3)C5(CC5)C2)=N1 CNC(=O)C1=CC=C(C2=CC=C(C(=O)NCC3CC(C)C3)C(C)=C2F)C=C1 COCC(COC)C(=O)N1CC[C@@](C)(NC(=O)C2=CC([N+1](=O)[O-1])=C(O)C=C2N)C1 C[C@@H1](CC1=CC=C2C(=C1)CCCC2)NC(=O)C3=CC=C4C(=C3)NCCO4 CC(=O)N[C@@H1]1CCOC2(CCN(C(=O)[C@@H1]3C4CCN(CC4)S3(=O)=O)CC2)C1 COC1=CC(Br)=CC=C1CCNC(=O)[C@@H1](C)NC(=O)C2CCCC2 CCOC(=O)[C@@H1](C)N(C)C(=O)[C@@H1]1CNC(=O)CN1C(=O)CC[C@@H1](C)OCC CC[C@@H1](SC)C(=O)N[C@H1]1C2C[C@H1]3[C@@H1](C2)C13C(=O)N(C)CCC4CCCCCC4 CC1=NC(CCSC2=NN=C(CCCO)N2[C@H1]3CCO[C@@]4(CCOC4)C3)=CS1 CCOC1CN(C(=O)C2CC(O)(CNC(=O)C3(N(C)C)CCC3)C2)C1 C#CC[C@@](C)(NC(=O)COC1CCCCC1)C(=O)N[C@H1]2C[C@H1](O)[C@H1](O)C2 C[C@H1](NC(=O)CSC1=CC=CC=N1)[C@@H1](C)NC(=O)CC2=CC=CC=C2 O=C(NCC[C@@H1]1CN(C(=O)C2=N[NH1]C(C3CC3)=N2)CCO1)C4=CN5C(=N4)COCC5 C[C@@H1](C(=O)N(CCCNC(=O)C#C[C@@H1]1CCOC1)C2CCCC2)C=3C=CSC=3 CCOC(=O)C1(C(=O)NCC(C)(C)NC(=O)CN2C(=O)CNC2=O)CCC1 CC[C@@H1]1C[C@H1]1C(=O)N2CCO[C@@H1](CN(C)C(=O)C3=C(Cl)C(C)=NN3C)C2 C[C@H1]1[C@@H1](C)[C@@H1]1C(=O)N2CCN(C(=O)C3=CN4C=C(Cl)C=NC4=N3)C[C@@H1]2C(C)(C)C CC(=O)NC1=CC(I)=CC=C1C(=O)N2CCC(C3=CC=NC=N3)CC2 CC[C@@H1](C)[C@H1](O)CC(=O)NCC1=CN(CC(=O)NC[C@H1](O)C(=O)OC)N=N1 C[C@@H1](CCNC(=O)C1=CN(CC2CCOCC2)N=N1)NC(=O)C[C@H1](O)CN(C)C CSCCNC(=O)C[C@@H1]1CN(C(=O)C[C@@H1](C)C2CC2)C(C)(C)C1 CC(C)[C@]1(O)CCCN(C(=O)[C@]2(C)C=CCN2C(=O)C3=CC=C(N)C=N3)C1 CCC1=NC(C)=C(C(=O)N[C@@H1]2CN(C(=O)C3=CC=C(F)C(F)=C3F)C[C@@H1]2O)O1 CCOCCCCCC(=O)NC[C@H1]1CC[C@H1](C(=O)N2C[C@@H1](O)[C@H1](O)C2)CC1 C#CCN(C(=O)C=1OC=C2C=1CCCC2)C3CCN(C(=O)CCC(C)(C)C)CC3 CCCC[C@H1]1CN(C(=O)COC2CC2)CCN1C(=O)CC3(C)CCC3 CC1=CC(Br)=C(C(=O)NCCCNC(=O)[C@H1](C)C2=CC=C(C)O2)N=C1C O=C(NCCCC1=CC=CC=N1)C=2N=COC=2Br COC(CCCC(=O)N1CC(C)(NC(=O)[C@H1]2C[C@H1]3CC[C@H1]2C3)C1)OC CCC1=CC=C(NC(=O)[C@H1]2CC(=O)CN2C(=O)[C@@]34CC[C@@H1](CC3=O)C4)C=C1 CC[C@@H1](CNC(=O)C1=C[C@]2(CCN(C(=O)C3=CC4=CC=CC=C4[NH1]3)C2)C1)C(C)C CCC(CC)[C@](C)(NCC(=O)N1CCOCC1)C2=NN=NN2C3(C)CC3 CC1=CC=NC=C1CC(=O)N(C)[C@H1]2CC[C@H1](NC(=O)C3=CN(CCO)N=N3)C2 CCC1=NC=C(CNC(=O)[C@@H1]2C[C@H1](CC)CCN2C(=O)[C@@H1]3CCCN3C4CC4)[NH1]1 CC(C)C1=CC(C(=O)N2CCCN(C(=O)[C@@H1](C)N3CCCCC3)C[C@H1]2C)=NN1C CCCCC[C@H1](C)CC(=O)N1CCC[C@H1](NC(=O)C2=NN=C3N2CCCCC3)C1 CO[C@@H1]1CN[C@H1](CCNC(=O)CCCC2=CC=C(F)C(F)=C2)C1 CCC1=CN=CC(NC(=O)[C@H1]2C[C@H1]3CC[C@@H1]2N3C(=O)C4=CN=CN(C)C4=O)=C1 COC(=O)NC(C)(C)C(=O)N[C@@H1]1C=C[C@H1](CC(=O)NCCC=2OC=NC=2CO)C1 CC(C)(CC(=O)N1C[C@@H1](O)[C@H1](NC(=O)[C@H1]2CCCC23CCC3)C1)CC(F)F CC(C)C=1C=CSC=1C(=O)N(C)CCCNC(=O)[C@H1]2CCCOC2 CO[C@H1]1CCC[C@@H1](CC(=O)N2CCN(C(=O)C3=CN=CS3)CC(C)(C)C2)C1 CC(C)C[C@@H1](C(=O)NC[C@H1]1C[C@@H1](C(=O)N(C)[C@H1]2CCOC[C@H1]2C)CO1)N(C)C CC(=O)NCCC(=O)N1CC[C@@H1](NC(=O)C2CC(C)(C)C2)C[C@@H1](O)C1 COC(=O)C1=CC(=NC[C@H1](C)NC(=O)[C@@H1]2CN3CCN2C[C@@H1]3C)[NH1]C=N1 CC=1C=NSC=1C(=O)N(C)C[C@@H1](C)NC(=O)C2=CC(Cl)=CC([N+1](=O)[O-1])=C2 CCCSCCC(=O)NCC[C@@H1]1CN(C(=O)C2=CC=C(C)N=C2O)CCS1(=O)=O CCC1=NN=C(C(=O)N[C@@H1]2CN(C(=O)C[C@H1](C)N3N=C(C)C=C3C)C[C@H1]2OC)S1 C[C@@H1](C(=O)N(C)CC1(NC(=O)[C@]23C[C@H1]2CCC3(F)F)CC1)N4C=C(Br)C=N4 C[C@H1](CCC(=O)N1CCC(C)(CNC(=O)CCC2CCN(C)CC2)CC1)N(C)C CNC(=O)C1=CN=CC(/C=C/C(=O)N2CC[C@@H1]2CNC(=O)C3=CN=C(C)N3C)=C1 CCN1C=CC(C(=O)N2C[C@@H1](O)[C@@H1](CNC(=O)C3=N[NH1]C4=C3CCCC4)C2)=C1C CC(C)[C@H1](C)CC(=O)N[C@H1]1COCCN(C(=O)C2CN(S(=O)(=O)C(F)F)C2)C1 CCC(=O)CCC(=O)N1CCN(C(=O)C2(OC)CCCCC2)CC1 CCC1=C[NH1]N=C1C(=O)NCC(=O)NCC(=O)N2C[C@H1](C)C[C@@H1](OC)C2 CC[C@H1]1CN(C(=O)NCCC2=NC3=C(S2)CCCC3)C[C@H1](CC)O1 C[C@@H1](CC(=O)NC(C)(C)CNC(=O)CC1=CC=C2N=C(O)[NH1]C2=C1)C(C)(C)C C=C(C)C(C)(C)C(=O)N[C@H1]1CCCCN(C(=O)CN2CC(=O)N(C)C2=O)C1 CCC1=NO[C@@H1](CC(=O)N2C[C@H1]3CCN(C(=O)CCC4CC4)[C@H1]3C2)C1 CCC1=CSC=C1C(=O)NCCCN(CC)C(=O)C2=CN=C3N2C[C@@H1](C)CC3 CC12CC(CNC(=O)C=3C=NN4C(OC)=CC=CC=34)(C1)C2 CCOC1=CC(C(=O)NC(C2NC(=O)[C@H1](O)CC(C)C)CCC(F)(F)CC2)=NN1 CC1(C)CCC[C@@H1]1C(=O)N2CCO[C@H1](CCNC(=O)C3=CC=C(F)C(Cl)=C3F)C2 CC1=CC=C([C@H1]2CCN(C(=O)NCC3=CC=C(NC(=O)C(C)C)C=C3)C2)C=C1 CCCCN(CCOC)C(=O)[C@H1](CC(C)(C)C)NC(=O)C=1N=C(C)OC=1C C1C=CC(NC(=O)C2=CC=C3NC=C(C4=CN=CC(CO)=C4)C3=N2)=CC(C)=N1 C[C@H1](CNC(=O)[C@@]1(CNC(=O)C(=O)C2CCCC2)CC13CCC3)N(C)C CN(CCO)CCC(=O)NCCC1(CNC(=O)[C@@H1]2CN3CC[C@@]2(C)C3)CC1 CC1=CC=C(C2=CN=C([C@@H1]3CCCN3C(=O)NC(C)(C)[C@H1]4CCCOC4)[NH1]2)C=C1 COC1=CN=CC=C1C(=O)N[C@H1](C)[C@H1](C)C(=O)N[C@H1]2CC[C@H1](O)C2 O=C(CC1=CN=CC(F)=C1)N[C@@H1]2CCN(C(=O)C3=C[NH1]N=C3[N+1](=O)[O-1])C[C@@H1]2F O=C(O)C[C@@H1](O)C(=O)NCC1=CC=C(N2CCC(O)CC2)C=C1 CCN(CC1CCN(C(=O)[C@H1](C)C2=CC=C(Cl)S2)CC1)C(=O)C3CC(=C(F)F)C3 CCCCCC[C@H1](F)C(=O)N[C@H1]1CCCC[C@@H1]1NC(=O)CO C#CCCC[C@@H1](C)C(=O)N1CCO[C@H1](CCNC(=O)CSC2=CC=CC=N2)C1 COC1=CC=C(CN2CCC[C@H1](C(=O)NCCC3=CC=CO3)C2)C(OC)=C1Cl COC(=O)C1=CC(F)=C(N[C@@H1](C)C(=O)NCC(C)C)C=C1F CCN(CCNC(=O)[C@H1](CCSC)NC(N)=O)C(=O)CC=1SC=CC=1Cl O=C(N[C@@H1](C1=CC=CC=C1)C(F)(F)F)C2=CC(Cl)=CC3=C2CCC3 CC(C)(O)C1CCN(C(=O)C2=CC3=CC(C4=CC=C(CO)O4)=CC=C3O2)CC1 CCCC[C@H1](F)C(=O)NC[C@H1]1C[C@@H1](C(=O)NC[C@@H1]2C[C@H1]2C3CCCC3)CO1 COC[C@@H1](CCO)NC(=O)C1=CC[C@H1](NC(=O)C=2C=COC=2)C1 C#CC[C@@](C)(NC(=O)[C@H1]1CC(=O)N(CC)C1)C(=O)NC2(C)CC(F)(F)C2 O=C(N[C@@H1](CCC1CCC1)C(=O)N2CC[C@@H1]2C3CCCC3)C4=CC=CC(CO)=N4 C=CC[C@H1](C)NC(=O)C[C@H1]1CCCN(C(=O)CCN2CCCC2=O)C1 O=C1CC[C@@H1](CC(=O)NCC[C@H1]2C[C@@H1](NC(=O)[C@H1]3CCC4=C[NH1]N=C4C3)C2)CN1 CC(C)(CNC(=O)C(N)=O)OCCNC(=O)[C@H1](CC(F)(F)F)C1=CC=CC=C1 C=C[C@@H1](C1CC1)N(C)C(=O)[C@@H1](COCC)NC(=O)C2=NOC=C2C CN1C=NC(C(=O)N2C[C@H1]3C[C@@H1](NC(=O)COC4CCCCC4)[C@H1]2C3)=C1 O=C(N[C@@H1]1CCN(C(=O)[C@@H1](F)C2CCC2)CC[C@@H1]1CO)C3=CC=CC(Cl)=C3F CC1(C)C[C@@H1](NC(=O)[C@@H1]2CCCCCN2C(=O)C34CC(C#N)(C3)C4)CCO1 COC1=CC=C(CN=C2C=C(C)N=C(N[C@H1]3CCCC4=CN=CC=C43)[NH1]2)C=N1 C=CC[C@]1(NC(=O)[C@H1]2C[C@H1]3CC[C@H1]2C3)CCCN(C4=NC=C5C=CC=NC5=N4)C1 C[C@@H1](CNC(=O)C[C@H1]1CCCN(C)C1)NC(=O)C2=NC3=C(S2)CN(C)CC3 CC1(C)[C@@H1](CC(=O)NC2CCN(C(=O)C34C[C@H1]5C[C@@H1](CC(C)(C5)C3)C4)C2)C[C@H1]1O CS(=O)(=O)C1CC(CNC(=O)[C@]2(C(F)F)CC2(F)F)C1 CC=1N=C(C2=CC(Cl)=CC=C2Cl)SC=1C(=O)N3CCOC[C@H1](N4C=NC=N4)C3 O=C(CC[C@@H1]1CCCOC1)NCC2[C@@H1]3CN(C(=O)C4(O)CCCCCC4)C[C@@H1]23 C#CC1=CN=CC(NC(=O)[C@]2(C)CCN3C=CN=C3C2)=C1 CC[C@H1](C)[C@H1](NC(=O)CN1CC(C)(OC)C1)C(=O)N2CCCC3=NC=CN32 CCCCCCCCC(=O)N1CC[C@H1](NC(=O)C=2C=NN(C)C=2COC)[C@H1]1C CC1=CC=C(Br)C(CC(=O)NC[C@@H1](O)C[C@@H1](NC(=O)C2=CN(C)C=N2)C)=C1 C[C@@H1](CCN(C)C(=O)C1(F)CCCCC1)NC(=O)C=2C=NN3C=2OC[C@H1](O)C3 CC(=CC(=O)NC1=CN=C(Cl)C(C)=C1)CNC(=O)C2(CCF)CCC2 CNC1=CC=C(C(=O)N2C[C@H1](O)[C@H1](NC(=O)C=3C(C)=NOC=3C(F)(F)F)C2)N=C1 C=CC[C@@H1](CNC(=O)C(F)(F)C1=CSC=N1)NC(=O)C=CC2=C(F)C=CC=C2F CCC[C@H1](O)C(=O)N1C[C@@H1]2[C@@H1](C1)[C@H1]3CC[C@@H1]2N(C4=CC(=O)N(C)C(=O)N4C)C3 CCCCC(=O)N1CCCN(C(=O)C2=NO[C@@H1]3COC[C@H1]23)C[C@@H1]1C CCC(C)=C(C)C(=O)N1CCO[C@H1]([C@@H1](C)NC(=O)COC(C)(C)CC)C1 CC1=CC(C(=O)N[C@H1](C)[C@@H1]2CCN(C(=O)C=3C=C[NH1]C=3C4CCC4)C2)=CC=C1F CCOCCNC(=O)[C@@H1](CCCC1=CC=CC=C1)N2CC[C@@H1](OCC(C)C)C2 CCOC(=O)[C@]1(C(=O)NC[C@H1](C)N(C)C(=O)C=2SC=NC=2COC)CCCCO1 CC1=NC(C)=C(C(=O)N[C@H1]2C[C@](C)(NC(=O)[C@H1](O)CN3C=NC=N3)C2)N=C1C CC(C)(CC(=O)NC[C@H1]1CN(C(=O)C2=CN=C(S)N=C2)C(C)(C)C1)CC(F)F CC=1OC2=CC=CC=C2C=1CCN([C@H1](C(=O)NCC3=CC=CC=C3)C(C)(C)C)C C=C(CCNC(=O)C1=CC=C(C)C=C1O)CNC(=O)[C@@H1][S@](=O)CCC(F)(F)F CO[C@H1]1C[C@H1](C(=O)N2CC([C@@H1]3CCCN(C(=O)C[C@@H1](C)C4=CC=NC=C4)C3)C2)C1 C=CCC1(C(=O)NCCCC[C@H1]2CCCN(C(=O)[C@@](C)(CC)OC)C2)CC=CC1 CCO[C@@H1](C)C(=O)N1C[C@H1](CNC(=O)C(C)=CC2=CC=NC=C2)CC1(C)C CCC1=CC(C(=O)N(C)C[C@@H1](CC)NC(=O)CCN2CCCC2=O)=NN1C C=C[C@@H1](CC)CC(=O)N1[C@@H1]2CN(C(=O)C=3C=CC4=NN(C)C=C4C=3)C[C@@H1]2C[C@H1]1C CC(=O)NCCCCC(=O)N1CC(F)(C(=O)NCC[C@@H1]2CCN(C)C2=O)C1 CCCC=1N=C(C2=CC(Cl)=CC(Cl)=C2F)N(C[C@@H1]3C[C@@H1]3C)N=1 CCC=CC=CC(=O)NC1CCC(N2CCN(CC=3C=NN(CC)C=3)CC2)CC1 CCS(=O)(=O)N1CC(C)(C(=O)NC2=C(Br)C=NC(C)=C2[N+1](=O)[O-1])C1 CN1C=C(C(=O)N2CC[C@H1]2C3=CN(CCCF)N=N3)C4=CC=CN=C41 CC[C@@H1](CNC(=O)C[C@@H1]1CCCCN1C(=O)C#CC2CCOCC2)N(C)C COC(=O)[C@H1]1CCC[C@@H1](OC(=O)CSC2=NN=C(C3=CC=CC=C3)O2)C1 CC1(C)[C@@H1](C(=O)NCC2(C#N)CCC2)C[C@H1]1NC(=O)CC3=CC=CS3 CS[C@@H1](C(=O)N(C)CCN(C)CC1=NN=C(C2=CC=CC=C2)O1)C3=CC=CC=C3 CCCC1=NC(C(=O)N2CC[C@@](CF)(NC(=O)C3=CN=CC=4N=C[NH1]C3=4)C2)=CO1 CCO[C@H1]1C[C@@H1]1C(=O)NCCC2(CNC(=O)C3=CN=C(N)C(O)=C3)CC2 CC[C@H1](F)C(=O)N[C@H1](C)[C@@H1]1CCCN1C(=O)C2=CN=C3C(C)=NSC3=C2 CC(C)C[C@H1](NC1=CC=CC=C1)C(=O)N2CC[C@@H1](N(C)C)C2 CC1=CC(=O)OC(C)=C1C(=O)N2CC[C@H1](C3=CC=CC(F)=C3)[C@@H1](NC(=O)CCF)C2 CCC1=CC(C(=O)N2CC(CNC(=O)C3=CC=[N+1]([O-1])C=C3)C(COC)C2)=NO1 CCOC(=O)C1=CC=C(C(=O)NC[C@H1]2CCN(C(=O)CN3C=CN=C3C)C2)C=C1 CN(CCN=[N+1]=[N-1])C(=O)[C@H1]1COC[C@H1]1NC(=O)C2=CC=C(C3CC3)O2 CC[C@@H1](CC(=O)N1CCN(CCF)CC1)N(C)C(=O)C2=CN=CC=3[NH1]C=CC2=3 C[C@H1](CC1CC1)C(=O)N(C)[C@@H1]2CCN(C(=O)C3=NN(C)C=C3Br)C2 CCOC[C@@H1](C(=O)N1[C@H1]2CC[C@@H1]1C[C@H1]2CNC(=O)C3COC3)N(C)C COC1=CC=C(Br)C(C)=C1C(=O)N2CC3(CN(C(=O)C=CCF)C3)C2 C=CC[C@]1(NC(=O)[C@H1](O)[C@H1](C)CC)CCN(C(=O)[C@]23C[C@H1]2CNC3=O)C1 C=C=CCC(=O)N[C@H1]1CCN(C(=O)CCC(=O)C2=CC=C(C)C(C)=C2)C[C@H1]1C C[C@H1](SC1=CC=CC=C1)C(=O)N(CCNC(=O)[C@H1]2C[C@@H1]2C)C3CCCCC3 C#CC[C@@H1](C)C(=O)N1CCC2(CCCN2C(=O)CC=3C=COC=3)CC1 CC1(C)C[C@@H1](NC(=O)[C@]2(C#N)CCCOC2)CN1C(=O)C3=CN4C(=N3)CCC4 COC1=CC=C(C(=O)N(C)CCN(C)C(=O)[C@H1]2C[C@@H1]3CC[C@H1](C2)[C@@H1]3O)O1 CCC(=O)NC1=CC=CC(C(=O)N2C[C@H1]3CS(=O)(=O)C[C@@]3(C=4N=N[NH1]N=4)C2)=C1 C[C@@H1](CN=C1N=C(N2CCOCC2)[NH1]C(=NC[C@@H1]3CCSC3)[NH1]1)C4=CC=CC=N4 CC(C)C1=CC=C(C(=O)NCCCCCCNC(=O)[C@@H1]2CC[C@H1](C#N)C2)N=C1 CN1CCC[C@H1]1C=CC(=O)N2CC(C)(C(=O)N[C@@H1]3CO[C@H1](C(F)F)C3)C2 COC1=CC=C(C(=O)NC[C@@H1]2C[C@@H1](O)[C@H1](NC(=O)C[C@@H1](C)C(F)(F)F)C2)C(C)=C1 CCOC(=O)[C@H1](F)C(=O)N1C[C@@]2(CNC(=O)C3=CC(Cl)=C(F)C(Cl)=C3)CC[C@H1]1C2 CSC1=CC=CC(C(=O)NC[C@](C)(NC(=O)C2=CC=C([N+1](=O)[O-1])C=C2)C3CC3)=C1 C#CC[C@@H1](C)C(=O)NC1CCC(NC(=O)C=2C=CN(C3=CC=CC=C3)N=2)CC1 CCC1=N[NH1]C=C1C(=O)N(C)C[C@H1]2CCCN2C(=O)[C@@H1](OC)C3=CC=CC=C3 CC[C@H1](C(=O)N1CC[C@H1](CN=C2C=C(C)N=C(Cl)[NH1]2)[C@@H1](C)C1)[C@@H1](C)O CCC[C@H1](NC(=O)[C@@H1]1CCN(C(=O)CCC2=CN=CO2)C1)C3CCC3 N=C1N=C(C(=O)N[C@H1]2CC23CC(NC(=O)[C@H1]4COCC4(C)C)C3)C5=CC=CC=C5[NH1]1 O=C(CCC1=NN=CN=C1O)N2CC3(C[C@H1](NC(=O)[C@]4(F)CC=CCC4)CO3)C2 CC[C@H1]1C[C@@H1](C(=O)NC2=CC=CC(NC(=O)C(C)(C)C3CCCC3)=C2)CCO1 O=C(NCCOC1CC1)[C@@H1]2[C@H1](O)CCN2C(=O)C3CCC4(CC3)CC4 COC(=CC1=CC=CC=C1)C(=O)N[C@H1]2CCN(C(=O)C3=CC(N)=CN=C3C)[C@@H1]2C C=C=C[C@@H1](C)C(=O)NC1CCN(C(=O)C2=CC=C(C)C=3[NH1]C(C)=CC2=3)CC1 C#C[C@@]1(C(=O)NC[C@@](C)(O)C(C)C)CCN(C(=O)CC=2C=CSC=2C)C1 CC(C)=C(C)C(=O)N(CCO)[C@@H1]1CCCN(C(=O)[C@](C)(F)C2=CC=CC=C2F)C1 CO[C@@H1]1CC(C(=O)N2CC[C@H1]2CNC(=O)CS(=O)(=O)CCO)C[C@H1]1OC C=CCC1(CC(=O)N2CC[C@@H1](C3(C)CC3)C2)CN(C(=O)[C@@H1]4CCC[C@H1](O)C4)C1 O=C(C[C@]1(O)CCOC1)N[C@]23CO[C@H1](C2)[C@H1](NC(=O)[C@@H1]4CCCC5=CN=CN54)C3 CC=1N=C(C(=O)NC2CC([C@@H1](C)NC(=O)CCCC(F)(F)F)C2)N(C)N=1 CCC[C@@H1](C(=O)N1CC(NC(=O)[C@@H1](OC2=CC=CC=C2C#N)C(C)C)C1)C(C)C CC1(C)C[C@@H1](CNC(=O)C2=CC=C(F)N=C2)N(C(=O)[C@@H1]3[C@H1]4CC[C@H1]5[C@@H1](C4)C[C@H1]53)C1 O=C1CC[C@@H1]2CN(C(=O)CN3C=C(C(F)(F)F)C=N3)CC[C@H1]2N1 CC1=CC=C2C(=C1)N(S(=O)(=O)C3=CSC(CC4=CC=CC=C4)=N3)[C@H1](C)C(=O)N2 CC(C)C[C@@H1](CNC(=O)[C@@H1](O)C1=CC=CO1)NC(=O)C=CCN(C)C O=C(N[C@@H1]1CC[C@H1](NC(=O)C=2SN=C3C=CC=CC=23)C1)C=4C=CC5=NON=C5C=4 CN=C1[NH1]C(=NCC2CN(C(=O)OC)C2)[NH1]C(=N[C@@H1](C)CC3=CC=CC(Br)=C3)[NH1]1 CNCC1=CN(C[C@H1]2C[C@H1](NC(=O)C3CCN(S(=O)(=O)N(C)C)CC3)C2)N=N1 CCC1([C@@H1](C(=O)NC2=CC=C(OC)C=C2)N3C[C@H1](C)O[C@H1](CC)C3)CC1 CCC[C@H1](NC(=O)C1(OC)CC(C)C1)[C@H1](O)C(=O)NCC[C@H1]2CCCN(C)C2 COC[C@H1](OC)C(=O)N[C@H1](CCN(C)C(=O)CC1=C(C)C=CC=C1F)C(C)C COC1CCC(CC(=O)NC[C@@H1]2CCN(C(=O)C(C)(F)F)C[C@H1]2O)CC1 CCN1CCC[C@H1](C(=O)N(CCO)CCCNC(=O)C=2OC=CC=2C)C1 CC(=O)CCCC(=O)N1C[C@H1]2C[C@@]2(NC(=O)[C@@]34C[C@@H1](F)[C@@H1]3C4)C1 CS[C@@H1](C(=O)N[C@@H1]1CN(C(=O)C2=C(C)C=C(C)N=C2Cl)C(C)(C)C1)C(C)(C)C CCC1=CC(C(=O)N2CC[C@@H1](NC(=O)C3=CN=C(Cl)S3)[C@H1](CC)C2)=NN1CCO C[C@@H1]1C[C@H1](CCNC(=O)CN2CCCNC2=O)CCN1C(=O)CC=3C=N[NH1]C=3 CCN(CC)[C@H1](C)C(=O)N1CC[C@@](C)(CC(=O)N2CC(C)(C)CC[C@@H1]2C)C1 CCC=1N=NSC=1C(=O)N2CCO[C@@H1](CN(C)C(=O)CC3=NN=C(C)O3)C2 C=C[C@@H1](CC)CC(=O)N1CCN(C(=O)CSCC2=CC=CC(Cl)=C2)CC[C@H1]1C COC1=C(F)C=C(C(=O)N(C)CCN(C)C(=O)[C@@H1](C)C#N)C=C1Br C#CCCN(C)CC(=O)N(C)CCCN1C=C(C=2SC=NC=2C(=O)O)N=N1 C#CCCC(=O)N1CC2CC(C[C@H1]2CNC(=O)[C@@H1]3C[C@H1]3C(F)F)C1 C=1OC=CC=1C(=O)NC[C@@H1]2CCN(CCCCN3CCCCC3)C2 C=CCCCCCNS(=O)(=O)C1=CC=C(N2C[C@H1](C)CCC[C@H1]2C)C=C1Br O=C(NCCO[C@H1]1CCN(C(=O)[C@@H1]2COC[C@H1]2C(F)F)C1)[C@H1]3CCSC3 CC(C)OC1=CC=C(C(=O)NC2(CCNC(=O)[C@H1]3COCCN3C)CC2)C=C1N C[C@@H1](CC1=CC=C(F)C=C1)C(=O)NCC2=CC=C(C(=O)NCCCCCCO)C=C2 CCSCC(=O)NC1CCN(CCNC(=O)[C@H1](C)CCC(C)(C)C)CC1 O=C(N[C@@H1]1CC[C@@H1](C(=O)N2CCC(OCC3=CC=CC=C3)CC2)C1)C=4C=NON=4 CCOC1=CC=CC(CC(=O)N2CC(CNC(=O)C3=CN=C(CC(C)C)[NH1]3)C2)=C1 CCCN1C=C(C(=O)N[C@@H1](C(=O)NC2C3CCC2CC3)C4CCC4)C=N1 CCCC[C@H1](CNC(=O)CC1=CC=C2C(=C1)CCCO2)NC(=O)[C@@H1]3CCCN3C CC1=NN(C)C=C1CC(=O)N(CCO)CCC(=O)N(C)C[C@@H1](O)C(C)(C)C CC1=NC=NC=C1C(=O)NC[C@@H1]2C[C@H1]3CC[C@@H1]2N3C(=O)C4=CC=C5OC=CC5=N4 C[C@@H1]1CN(C(=O)CSCC(F)(F)F)C[C@@H1](C)N(C(=O)C2=CC(N)=CC(F)=C2)C1 CC[C@@H1](C)C[C@@H1](CO)NC(=O)C=1N=COC=1CNC(=O)C2(CSC)CCC2 CCC1=CC=C(C(=O)N2CCC[C@@H1](C(=O)N[C@H1]3COC4(CCC4)C3)C2)[NH1]1 O=C1CS(=O)(=O)C[C@@H1](C(=O)N2CCCC[C@@H1]2CCNC(=O)[C@@H1]3C4C[C@@H1]5C3[C@@H1]5C4)N1 C[C@@H1]1C[C@H1](C(=O)NCCCC=2C=C[NH1]N=2)CN(C(=O)CCC3=NN=CS3)C1 CC(C)(CC(=O)NCCC[C@@H1]1CCCCN1C(=O)C2=COC(Br)=C2)CC(F)(F)F CCN(CC(C)(C)CNC(=O)C1=CCC[C@@H1]1P(C)(C)=O)C(=O)[C@@H1](F)C(F)(F)F O=C(CCC1=CN=CN=C1O)N2CC[C@H1]3CN(C(=O)CC4CC5(CC5)C4)[C@H1]3C2 CC=1C(C(=O)N[C@H1]2C=CCN(C(=O)[C@H1](F)C[C@H1]3CCOC3)C2)=N[NH1]C=1C4CC4 O=C([C@@H1]1C[C@H1]2C[C@@H1]2N1S(=O)(=O)C3=CC=C(Cl)S3)N4CCC[C@@H1]5CCCC[C@@H1]54 CCCC=1ON=C(C)C=1C(=O)N[C@@H1]2C[C@H1]2CNC(=O)[C@H1]3CC=C(C)CC3 CN1CSC[C@@H1]1C(=O)N2CCC([C@H1](F)CNC(=O)[C@H1]3C[C@@H1]3C(F)(F)F)CC2 CC(C(=O)N1C[C@H1]2COC[C@@]2(C(=O)N(C)OCC(F)(F)F)C1)=C3CCCC3 COC1(C(=O)NCCNC(=O)[C@H1](CCSC)NC(=O)OC(C)(C)C)CCCC1 C[C@H1]1CCN(C(=O)C=2N=C3C=CC=CN3C=2F)CCN1C(=O)CC=4C=COC=4 CC(C)C1=NC(CC(=O)NC[C@H1](NC(=O)C[C@@H1]2CCCSC2)C3CCCC3)=CS1 O=C(NCC(F)(F)F)C(=O)N1CCC(F)(CNC(=O)C2(N3CCCC3)CC2)CC1 CC1=NOC=C1NC(=O)[C@H1]2CN(C(=O)C3=CN=C4C(Cl)=CC=CN34)CC(F)(F)C2 CC1=NN(CC(=O)N[C@@H1]2CC[C@@H1]2NC(=O)C3=CC=CC(OC(C)C)=C3)C(C)=C1C COC1=CC=C(C(=O)NC[C@H1](NC(=O)/C=C/C2=C[NH1]N=C2C)C(C)C)N=N1 CC=CC(=O)N1CC[C@@H1](NC(=O)C2=CC=C3C(=C2)N(C)CC3)[C@H1](C)C1 CC(=O)N[C@@](C)(C(=O)N1CC[C@H1]2CC[C@@H1](C1)N2C(=O)C=C(C)C(F)F)C(C)C CCNC(=O)NCCNC(=O)[C@H1](COC(C)C)NC(=O)C1=CC(O)=NN1C CC1=CC(O)=NC(C(=O)N2CC[C@@H1](N(C)C(=O)[C@H1](C)C3CCCCCC3)C2)=C1 CSC1=CC(C)=C(C(=O)N[C@@H1](C)[C@@H1](NC(=O)C2=CN=CC(Cl)=C2)C(C)C)S1 O=C(N[C@@H1]1C[C@H1]1CNC(=O)[C@@H1]2C[C@H1]2F)C3=CC=C(N4N=CC(C#N)=C4O)C=C3 C=CC[C@@H1](CC)N[C@@H1](C1=CN(CCC)N=C1C)C2=NN=NN2CCC3CC3 C[C@H1](C(=O)N[C@@H1]1CC[C@H1]1NC(=O)CCC(=O)C2=CC=CS2)C3=CC=CC=C3Cl C[C@H1](O)CCCCCC(=O)NCC[C@H1]1C[C@H1](NC(=O)C2=C(Cl)C=CC(Cl)=C2O)C1 CO[C@H1](C)CN(C)C(=O)[C@H1]1N(C(=O)C(=O)C2=CC=CN2C)CCC1(C)C CC[C@@H1](C)OC1=CC=C(N[C@]2(C3=NN=NN3C4CCCC4)CCO[C@@H1](C)C2)C=C1 CN1CCC[C@H1](C(=O)N2CCN(C(=O)CC3(O)CCC3)C[C@@H1](CO)C2)C1 C#CCNC(=O)CC(=O)N[C@@H1]1CCN(C(=O)C2=CCSC2)[C@@H1](C)C1 COC[C@H1]1CN(C(=O)C2=CSCS2)CCN1C(=O)[C@H1]3CCCN3N=O CCOC1=C(Cl)C=CC=C1CC(=O)NCC2(NC(=O)[C@H1]3CCCN3C)CCC2 CC[C@H1]1OCC[C@@H1]1C(=O)N2CC3CC2(CNC(=O)C4=CN=CC(OC)=N4)C3 CO[C@@H1](CCNC(=O)C1(CNC(=O)[C@@H1]2CCCCNC2=O)CC1)C(C)C CC1CC(C(=O)N2CCC3(CC2)C[C@@H1]3C(=O)N(C)CC4=NN=NN4C)C1 O=C(COCC1=NC2=CC=CC=C2S1)NCC[C@H1]3COCCN3C(=O)C4CCC4 CC=1SC(O)=NC=1C(=O)N[C@H1]2C[C@H1](NC(=O)[C@H1]3C[C@H1](C)C3(C)C)C2 CCC=1C=NN(CC(=O)NC[C@H1]2CC[C@H1](NC(=O)C3(C)CCCCCC3)C2)C=1 CC[C@H1](C(=O)N1CCC(CN(C)[C@@H1](C)C2=CC=CC=C2Br)CC1)N(CC)CC COC(=O)[C@@H1](O)C1=CC=C(Cl)C=C1NC(=O)C(=O)N[C@@H1](C)C2(F)CC2 COCCCOCCC(=O)N(CC(=O)N1CCC[C@@H1](C)[C@@H1]1C)C2CCC2 N[C@@H1](CC1=CC(Br)=CC(Br)=C1)C(=O)N[C@@H1]2CCCC[C@H1](CO)C2 COCC[C@@H1](NC(=O)C=1C=CN(C)N=1)C(=O)N2CC[C@@]3(CCOC3=O)C2 O=C(C=CCF)NCC[C@H1]1CCCN(C(=O)C2=CC(C(F)(F)F)=NC=C2Cl)C1 C[C@H1](CCCC(=O)NCCCCN1CCC1)NC(=O)C2(F)CC2 CCN(CCCNC(=O)[C@H1](C)CC(=O)OC)C(=O)[C@H1](C)NC(=O)CN1C=NN=N1 CC1=NC=C2C=CC(C(=O)N(CCNC(=O)[C@@]3(F)CC3(F)F)C(C)C)=CN12 CC1(C)CC[C@H1](CC(=O)N[C@@H1]C2CCN(C(=O)C3=CC=C(C(N)=O)N=C3)CC2)C1 COC(=O)C[C@@H1](C)C(=O)N1C[C@H1](CNC(=O)C2=NN(C)C=C2[N+1](=O)[O-1])C(F)(F)C1 CC[C@]1(C(=O)NCC2(C[C@@H1](F)C(=O)NCCOC3CC3)CC2)CCCO1 CCN1C=C(C(=O)N[C@H1](C)[C@@H1]2C[C@H1]2C(=O)NCC(CC)(CC)CC)C(C)=N1 CN1CCN(C(=O)CCN2CCCCCC2)[C@@H1](CNC(=O)[C@H1]3CCCCO3)C1 O=C1CC[C@H1](N2CCN([C@H1](C(=O)NCC3=CC=CS3)C4=CC=C(Br)S4)CC2)CN1 CC(C)C(=O)N[C@@H1](C)C1(O)CCN(C(=O)C=2C=CC3=C(Br)C=NN3C=2)CC1 C[C@H1](NC(=O)C(=O)NC1CC1)[C@@H1](C)NC(=O)C2=CC=C(NS(C)(=O)=O)C=C2Cl CCN(CC)CCCCNC(=O)[C@H1](NC(=O)C1CC(CF)C1)[C@@H1]2CC=CCC2 CC(C)[C@H1](C)[C@@H1](CNC(=O)C1=CC(Cl)=C(F)C(Cl)=C1)NC(=O)C2=COC(Cl)=C2 CC1=CC(C)=CC(CCNC=C2C(=NCC(C)(C)OCCO)[NH1]C(C(C)C)=N2)=C1 CC(C)(C)[C@@H1]1C[C@H1](N2CC[C@@H1](COC(=O)C3=CC=CC=C3C=O)C2)C(=O)N1 C/C=C/CCCCC(=O)NC1(C(=O)NC[C@H1]2CCCOC2)CC(F)C1 C=CC[C@H1](CNC(=O)CC1=CC=CN=C1)NC(=O)C2(C(C)(F)F)CCC2 CC(=O)N1CC(C(=O)N2CC[C@](CF)(NC(=O)CC3=CC(C(C)C)=NO3)C2)C1 N#CC1=C[NH1]C(C(=O)N2CC[C@@H1](C3(NC(=O)CSC[C@H1]4CCCO4)CC3)C2)=C1 C=CCCOCCN=C1C=CC([N+1](=O)[O-1])=C(C)[NH1]1 CCN(CC1=CC=C(OC)C=C1)CC2=CC=CC(C#N)=C2F CO[C@H1]1C[C@@H1](NC(=O)C=2C=C(C)OC=2C)CN(C(=O)C3=CC(C)=C(O)C(N)=C3)C1 C=C[C@@](C)(O)CC(=O)N[C@H1]1CC[C@H1](NC(=O)[C@]2(C)CCCCC2(F)F)CC1 CC(C)(C)OC(=O)N1CSCC[C@H1]1C(=O)NC[C@H1]2C[C@H1](NC(=O)C(C)(C)F)C2 O=C1CC(CF)(C(=O)NC[C@]2(F)C[C@H1](CNC(=O)CC3=CCCCC3)C2)C1 COCC1(NC(=O)C2=CC(OC)=NC=C2F)CCN(C(=O)C=C(C)C(C)(C)C)C1 CCCC1=NC(C)=C(C(=O)NC[C@H1](CCOC)NC(=O)CC2=CN=CC=C2Cl)O1 CC1=CC=C([N+1](=O)[O-1])C(C(=O)N[C@H1]2CCN(C(=O)C3=NC(Cl)=C(Cl)S3)C[C@H1]2C)=C1 CC1=CC=C(C=CC(=O)N2CC[C@H1](N(C)C(=O)C3=CC(C)=C(N)C=N3)C2)S1 C=C(Cl)C[C@H1](NC(=O)CN(C)C(=O)COC)C(=O)NC1CCC1 CCC1(C(=O)N2CCN(C)[C@H1](CO)C2)CN(C(=O)[C@H1]3COCCN3CC)C1 COCC[C@H1]1C[C@@H1]1NC(=O)[C@H1]2CN(C(=O)[C@@]34CCC[C@H1]3C4(F)F)CC2(C)C CC1=CC(O)=NC(C)=C1C(=O)N(C)CCCNC(=O)C=2C(O)=NOC=2C CC1=CC=NC(C)=C1C(=O)N2CCN3C(=O)[C@H1](NC(=O)C(=O)NC(C)C)C[C@H1]3C2 C1=CC=C2C(=C1)CC[C@H1]2N[C@H1]3CCO[C@@H1]3C4CC4 C#CCN(CC#C)C(=O)[C@H1]1CCN(C(=O)C2=NC=CC=C2N)O1 CN1N=C(C(F)(F)F)C=C1CC(=O)N[C@@H1]2CN(C(=O)CC=3C=N[NH1]C=3)CC24CC4 CN(C(=O)C[C@@](C)(C1CCC1)N(C)C)[C@@H1]2CCN(C(=O)CCC3CCOCC3)C2 CC(C)OC1=CC=C(CN2CCCS(=O)CC2)S1 CCCC(=O)N1CCC[C@@H1]1C(=O)N2C[C@H1]3CCN(C(=O)C[C@@H1]4CC4(C)C)C[C@H1]3C2 CCO[C@H1](C)CCC(=O)NCC1(C(=O)N2CCCC3=NC=CN32)CCC1 C[C@@H1](C#N)C(=O)N1CC(CNC(=O)C2=CC(C=3C=NN(C)C=3)=CC=C2F)C1 CO[C@@H1](C)CCC(=O)N[C@H1](C)CN(C)C(=O)C=1C=NOC=1C2=CC=CC=C2 CC1=CC(C(=O)N(CCO)C2CCN(C(=O)[C@H1]3C[C@H1]4CC[C@H1]3C4)CC2)=NS1 CCCC[C@@H1](O)[C@H1](C)C(=O)NCC1(OC)CN(C(=O)C2=NC(C)=CC=C2OC)C1 CO[C@@H1](C(=O)NC1(CO)CN(C(=O)C=2C=COC=2Cl)C1)C3=CC=CC=C3 CSCC1=CC=CC(C(=O)NCC2=CCCN(C(=O)CC#N)C2)=C1 CCN(C(=O)CCOCCOC)C1CCN(C(=O)C=CC2CC2)CC1 CC[C@H1](C(=O)N1CC(O)([C@@H1](C)NC(=O)C=2C=CSC=2C)C1)C(C)(F)F CCCCS[C@H1](C)C(=O)NC[C@@]12C[C@H1]1CN(C(=O)COC=3C=CSC=3)C2 C=C[C@H1](C)NC(=NCCC1=NC=CC=C1C(F)(F)F)NC[C@H1]2CCO[C@H1]2C CCC1=CC=C(C2=CC=C(NC(=O)[C@@H1]3C[C@H1]3NC(=O)C4CCN(C)CC4)S2)C=C1 CCN1N=NC(C(=O)N[C@H1]2COCC[C@H1]2NC(=O)C=3C=NN4N=CC=CC=34)=C1C COC[C@H1](O)C(=O)N1CC[C@H1]2CC[C@@H1](C1)N2C(=O)CNC3=C(C)C=CC=C3C CC1=CC=C(OC2=CC=CC(NC(=O)C(=O)N3CCOC[C@H1](C4CC4)C3)=C2)N=N1 CC1=CN=CC(/C=C/C(=O)N2CCC[C@@H1]2CN(C)C(=O)[C@H1]3C[C@@H1]4C[C@@H1]4C3)=C1 CN1N=CC=C1[C@@H1]2C[C@H1]2C(=O)NCC[C@H1]3C[C@H1](NC(=O)[C@H1]4C[C@@](C)(O)C4)C3 C[C@@]12CC[C@@](C(=O)N[C@@H1]3CC34CC(NC(=O)C=5C=NN(C6CC6)C=5)C4)(C1)OC2 CSC1=C(C(=O)NC23CC(NC(=O)[C@@H1]4C[C@]45CCCOC5)(C2)C3)CC=NN1C C[C@H1](CNC(=O)C1=CC=C(F)C=C1Br)NC(=O)C2CC3(C2)C[C@@H1]3F CSC1=CC=C(CN[C@](C)(C2=NN=NN2C3CC3)[C@@H1](C)CCC=C(C)C)S1 C[C@H1]1[C@@H1](NC(=O)CC2=CC(C3CC3)=NN2C)CCN1C(=O)CC[C@H1]4CCCOC4 C[C@@H1](C(=O)NC(C)(C)C(=O)N[C@]1(C)CCC(C)(C)C1)C(F)(F)C(F)F COC(=O)[C@H1](OC)C(=O)N(C)C[C@H1](C)NC(=O)C1CCC(F)(F)CC1 CCSC1=CC=C(Cl)C=C1C(=O)N[C@H1](C)CNC(=O)C2=CN=NS2 O=C(NC1=NN=C(C2=CC=CO2)S1)C3=CC=C(N4C=CN=C4)C=C3 COC(=O)[C@H1]1CCN(C(=O)C2=CC(F)=CS2)O1 O=C(NC1=CC=C(C2CC2)C(Cl)=C1)C(=O)N3CCC[C@@H1](C(=O)N4CCCC4)C3 CC(C)NC(=O)NC1=CC=CC=C1C(=O)N[C@H1](C)C2=CN(C[C@@H1]3CCOC3)N=N2 C[C@@H1](C(=O)N1C[C@@H1](C(=O)OC=2C=N[NH1]C=2)CC(C)(C)C1)N(C)CC(F)(F)F C=C[C@H1](CC(=O)N1CCN(C(=O)[C@H1]2CCCC[C@H1]2O)[C@@H1](CCO)C1)C3=CC=CC=C3 CC[C@H1](CC1=CC=CC=C1Br)N(C)CC2=CC=NC(C)=C2N CC(=O)C(C)(C)CC(=O)N1CC[C@@H1](CNC(=O)C2=C(C)C=CN=C2C)C1(C)C O=C(CS(=O)(=O)C1CC1)N2C[C@H1](C(F)(F)F)C[C@@H1](NC(=O)C3(F)CC=CC3)C2 CCN(CC)C[C@H1](F)C(=O)N1CC[C@H1](C)[C@@H1](NC(=O)CC2CSC2)[C@@H1]1C CC1=CC(CN2C=C(C[C@H1]3CCN(C(=O)[C@@]4(O)CCSC4)C3)N=N2)=NO1 CC=1OC=NC=1C(=O)N2CCC(C)(C(=O)N[C@]3(C)CCC(C)(C)C3)CC2 CC(C)C[C@](C)(O)C(=O)N[C@@H1](CO)CNC(=O)C=1C=C(Br)N2C=1CCC2 C[C@H1](CCN(C)C(=O)CCC1(C#N)CCC1)NC(=O)[C@@H1]2CCN(C)S2(=O)=O N#CC=1SC=CC=1C(=O)NC[C@@]2(F)CC[C@H1](NC(=O)CS(=O)(=O)C3CCCC3)C2 C=C(C)CCCC(=O)N1CCC[C@](C)(CNC(=O)[C@]2(C)CC[C@@H1](C)C2)C1 CC1=CC(CCC(=O)N2C[C@H1](NC(=O)[C@H1]3CCC3(C)C)C4(CCCC4)C2)=NO1 CC1=C(Br)C=C(Cl)C=C1NC(=O)[C@H1]2[C@H1]3CN(CC4=CC=CC([N+1](=O)[O-1])=C4Br)C[C@H1]32 CC1(C)[C@H1]2CC[C@@]1(C(=O)NCC3=CC=C(C(=O)N4CC[C@@H1](CO)C4)C=N3)C2 C=CC=CCC(=O)N1CC[C@H1](CN(C)C(=O)C2=CC=C3C(=O)N(C)C(C)=CC3=N2)C1 C[C@]1(O)C[C@H1]2C[C@H1]1C[C@@H1]2NC3CCN(C4CCC4)CC3 COC(C)(C)CCCCC(=O)N[C@@H1]1C=C[C@H1](CNC(=O)CCN(C)C(C)=O)C1 C[C@@](O)(C(=O)N[C@H1]1C[C@]2(CCCCN2C(=O)C3=CC=4OC=CC=4[NH1]3)C1)C5CCC5 CCC1=C(C(=O)NC[C@]2(O)CCN(C(=O)[C@@H1](C)CC(N)=O)C2)N=NN1CC CC=1N=C([C@@H1]2CCCOC2)SC=1C(=O)NCCCNC(=O)CN3CCOCC3 C#CC1=CN(C)N=C1C(=O)NC2(CNC(=O)CSCC3=NC=C[NH1]3)CCOCC2 CC1=CC(C)=C(C(=O)N[C@H1]2C[C@H1](C)CN(C(=O)C=CC3=CC=C(F)C=C3)C2)S1 COC1(CNC(=O)C2=CC=CC(N(C)C)=N2)CN(C(=O)C34CCC3CC4)C1 C#CCNC(=O)CC(=O)N1CC([C@@H1](C)NC(=O)C(C)(C)C2=CSC=N2)C1 CNC(=O)CCCC(=O)N1C[C@H1](N=[N+1]=[N-1])[C@H1](NC(=O)C2(C)C(C)(C)C2(C)C)C1 CC[C@H1](CC(=O)NC[C@@H1](CC)NC(=O)C1=CC(N2CCCCC2)=NC=N1)C3CC3 CC=1[NH1]N=C(C(=O)N2[C@H1](C(=O)NC[C@H1]3CC34CCOCC4)CC[C@@H1]2C5CC5)C=1O COCC1(NC(=O)CC2=CC=CC=C2O)CCN(C(=O)C3=CN=CC(C)=N3)CC1 CCOC(=O)[C@H1]1C[C@](F)(C(=O)NC[C@@](C)(O)CNC(=O)C2=CCCCCC2)C1 C[C@@H1](NC(=O)C1=CC=C2C(=C1)CNCCO2)C3CC(F)(F)C3 CN1C(=O)OCC12CN(C(=O)[C@]3(C)CCCN3C(=O)C4CC5(CSC5)C4)C2 C[C@@H1](OCCN(C)C)C(=O)NCCOCCN(C)C(=O)CCCC1=CN=CS1 COCCS(=O)(=O)CC(=O)NCC1[C@@H1]2CN(C(=O)CN3N=NN=C3C4CC4)C[C@@H1]12 CCO[C@H1](CC(=O)N1CCN(C(=O)C2=COC=N2)[C@H1](CO)C1)C3=CCCC3 COC(=O)[C@H1]1[C@H1]2CCC[C@H1]2CN1S(=O)(=O)CC(C)(C)OCC(F)(F)F CC[C@H1](C)[C@H1](C(=O)NCC(=O)NCC(C)(C)C1CC1)N(C)C CCC1=CC=C(C)C=C1C(=O)N[C@@H1](CNC(=O)C2=CN=CC(C)=C2Cl)C3CCC3 CC1CN(CC(=O)N2C[C@@H1](NC(=O)C3=CC=C(F)O3)C[C@@H1](C)C2)C1 CN1C=NC(C(=O)N2CCN(C(=O)CC3=CC=C4N=CSC4=C3)C[C@@H1]2C)=CC1=O CC1=CC(OCCCNC(=O)/C=C/C2=CN=CC=N2)=NC(=O)N1C3=CC=CC=C3 CCN(CCNC(=O)C1=CC2=C(N=CN2C)[NH1]1)CC3=NN=C(C(C)C)O3 C=C[C@@]1(C(=O)N2CC[C@@](C)(C(N)=O)C2)CCN(C(=O)CN3C=NC(C#N)=N3)C1 C=C(CCNC(=O)C1(C2=CC=CC=C2)CCOCC1)CNC(=O)CCS(C)(=O)=O CC1=C(Br)C=CC(C(=O)N2CC[C@@H1](C3CC(NC(=O)C=4[NH1]C=NC=4C)C3)C2)=C1F O=C([C@@H1](O)CC1CC1)N2CC([C@H1]3CCCN(C(=O)C4(C5CCC5)CC4)C3)C2 CC(=O)NC1=CC=C(C(=O)NC[C@@H1]2CCN2C(=O)CC[C@@H1]3CCCOC3)C=C1 CS[C@H1](C)CCC(=O)NC1(C(=O)N2C[C@H1]3CN(C)CC[C@H1]3C2)CSC1 C=CCC(=O)N1CC[C@H1]([C@H1]2CCN(C(=O)C3=C[NH1]C(C(=O)OC)=C3)C2)C1 CC[C@H1](C)[C@H1](O)[C@H1](C)C(=O)NC[C@H1](CNC(=O)CC[C@@H1]1CC1(C)C)OC CCN1N=NC(C(=O)N2CCC(CNC(=O)CC=3C=C[NH1]C=3)(COC)CC2)=C1C CCN1N=C(C(=O)N2CCN(C(=O)C=CC=3C=NN(C)C=3)CC(C)(C)C2)C=C1O O=C(CO[C@H1]1CCOC1)N2[C@H1]3CC[C@H1]2CN(C(=O)C4(N5C=NC=N5)CC4)C3 CCC1=CC(C(=O)NCC2[C@@](N=[N+1]=[N-1])(C(=O)NCCOC(CC)CC)C2)=C(C)O1 C=C(CCNC(=O)C1=CC(OC)=CC=C1N)CNC(=O)C[C@H1]2CCC23CCC3 C[C@H1](NC(=O)C(C)(C)CCCO)[C@H1]1CCN(C(=O)CCCN2C=CN=C2)C1 C[C@H1](CC(F)F)NC(=O)NC[C@]1(O)CCC2=CC=CC=C21 CCOC1=CC=C(C(=O)N2CC=C[C@@H1]2CNC(=O)[C@@H1]3CCC(=O)NC3)C=C1 C=CC[C@@H1]1CCCCN1C(=O)[C@@H1]2CO[C@H1](CNC(=O)[C@H1](O)C3=CC=CC=C3F)C2 C=C1C[C@H1]1C(=O)N[C@@H1]2CCN(C(=O)CCC3=CC=C(C#N)C=C3)[C@H1]2C(C)(C)C CC[C@H1](CNC(=O)CC1=NC(C(C)(C)C)=CS1)NC(=O)[C@H1]2CCCC[C@@H1]2C3CC3 CCC[C@@H1](CC)C(=O)NC[C@H1]1CCC(C)(C)CN1C(=O)COCC2=NC=C(C)O2 O=C(NCCC1CN(C(=O)C(F)(F)C2=CSC=N2)C1)C3=CC=NC(C4CC4)=C3 CCC=CC(=O)N[C@]1(CO)CCN(C(=O)C2=CC=3SC(C)=CC=3S2)C1 COC1=CC=CC(C(C)(C)C(=O)NCCOCCNC(=O)[C@@]2(C)CCC(=O)C2)=C1 CC[C@@H1](O)C(F)(F)C(=O)NC[C@H1]1C[C@@H1](NC(=O)C=2OC=CC(=O)C=2OC)C1 N#CCC(=O)NC1(C(=O)N[C@H1]2CCCCC[C@@H1]2F)CCC1 C[C@H1](OC1COC1)C(=O)NCC2[C@H1]3CN(C(=O)C=4C=CON=4)C[C@H1]23 CN1CC[C@@H1](CNS(=O)(=O)C2=CC=CN=C2N[C@H1](CO)CCS(C)(=O)=O)C1 CC(C)(CO)[C@@H1](O)C(=O)NC[C@H1]1CCCC2(CCC2)O1 CS[C@@H1](C)C(=O)N1C[C@H1]2CCC[C@H1]2[C@H1]1C(=O)NCC3=CC=CC(C)=C3O CC=1C=NSC=1C(=O)N2CC[C@](NC(=O)[C@@]34CCC[C@H1]3C4(F)F)(C5=CC=CC=C5)C2 COC1=CC=C(C(=O)N[C@H1]2C[C@@H1]2NC(=O)CCN3N=CN(C)C3=O)C(O)=C1 CCCCCC(=O)N1CCN(C(=O)C[C@@H1](O)CCCC)[C@H1](CC(F)F)C1 N=C1[NH1]C(C2=CC=C(C(=O)NCCNC(=O)C=CC3=NC=CS3)C=C2)=CS1 CN(CC(=O)N[C@@H1]1C[C@H1]1CNC(=O)C2=CN=C(C3=CC=C(F)C(F)=C3)S2=O)CCC CN1CC2(C1)CN(C(=O)[C@@H1]3CC[C@@H1](C4CC4)N3C(=O)CC5CCCCCC5)C2 C[C@@H1](CC(=O)N(C)CC1(NC(=O)C2=CC=C(F)C(O)=C2F)CC1)P(C)(C)=O COCC1(CC(=O)N2CC[C@]3(NC(=O)C4=CC=[N+1]([O-1])C=C4)CCC[C@H1]23)CCCC1 COCCNC(=O)C(=O)NCC[C@@]12CC[C@@H1]1CN(C(=O)C3=CN=C(O)C=C3C)C2 C[C@@]1(CNC(=O)[C@@H1](F)CC2CCCC2)CCN(C(=O)C=3C=C[NH1]C(=N)C=3Cl)C1 CNS(=O)(=O)C1=CC=C(C(=O)NC[C@@H1]2C=CCN2C(=O)[C@@H1]3C(C)(C)C3(F)F)C=N1 CC1=NC(O)=C(Br)C=C1C(=O)N2C[C@@H1](NC(=O)CCC(N)=O)CC[C@H1]2C CC1=NN=C(CC(=O)NCC2(O)CC(NC(=O)C3=CC(C)=NC(Cl)=C3)C2)O1 C[C@@H1]1C[C@H1](C(=O)N(C)[C@@H1]2CN(C(=O)CC3=COC(C(F)F)=N3)CC24CC4)CN1C NC(=O)C1=NC(C(=O)N2CCCC23CCN(C(=O)[C@@]4(CO)CCOC4)CC3)=CS1 CCC1=CC=C(C=CC(=O)N(C)[C@@H1]2CC[C@@H1](NC(=O)CN(C)CC)C2)O1 C[C@]1(O)C[C@@H1](C(=O)NC[C@@H1]2C[C@@H1]3CCC[C@@H1]3N2C(=O)[C@H1]4CCCCC(F)(F)C4)C1 C#CC[C@]1(C(=O)NCC[C@@H1]2CCCN2C(=O)C3=CC=CC=C3CC)CC=CCC1 CC1=NN(C)C(N)=C1C(=O)NCC=2C=NN(C)C=2C(=O)NCC(C)(C)N(C)C CCC1=NC(=N)[NH1]C(=NC[C@](C)(CC(C)C)NC(=O)C2=NC=C(C(F)F)S2)[NH1]1 CN1C=NC=C1C(=O)N2CC[C@@H1](F)[C@@H1](NC(=O)[C@H1]3COCCN3CC4CCC4)C2 CCCN1N=CC(C(=O)N2C[C@H1]3CCN(C(=O)C[S@](=O)CC)[C@H1]3[C@@H1]2C)=C1C4CC4 CCN(C)C[C@H1]1CCN(C2=NC3=CC=CC=C3N=C2N[C@@H1]4CCCC(F)(F)C4)C1 CO[C@@H1](CNC(=O)[C@H1](F)C1CC1)C(=O)NC=2C=NN(C(C)C)C=2C CC[C@H1](SC)C(=O)NCCOC1CCN(C(=O)C[C@H1]2NC(=O)NC2=O)CC1 O=C(CCN1CCCC1)N[C@@H1]2C[C@@H1]3CC[C@H1](C2)N3C(=O)C4=NC=CO4 C[C@H1]1[C@@H1](NC(=O)CCCC(C)(F)F)C[C@H1]2CC[C@H1]1N2C(=O)C=3C=NN(C)N=3 COC1=NC=CC=C1CC(=O)N2C[C@@H1](NC(=O)CS(=O)(=O)C(C)C)C3(CC3)C2 C=CCC[C@H1](C)NC(=O)C1([C@H1](C)NC(=O)C2=CC=C(C#N)O2)CC1 C[C@H1](C(=O)N[C@@H1]1CCN(C2=CC=C(Cl)C(F)=C2)C1)N3C=NN=N3 COC[C@@](C)(O)C(=O)N[C@@H1]1CN(C(=O)C(CC(C)C)CC(C)C)C[C@H1]1CC2CC2 CN(C[C@H1](O)CNC(=O)C1CC(C)(C#N)C1)C(=O)CCC2=CN=CN2C C=C(C(=O)N1CCC(NCC2=CC(Cl)=C(Cl)C(Cl)=C2)CC1)C(F)(F)F O=C([C@@H1]1CSCCS1)N2CCC([C@@H1]3CCCCN3C(=O)C=4C=CON=4)CC2 C[C@@H1](C(=O)NC1CCCCC1)N(C)CCN(C)C2CC2 CC[C@@H1](CC(F)F)C(=O)N[C@@H1](C)CC1CCN(C(=O)[C@@H1]2CCC(C)(C)C2)CC1 CCC[C@@H1](OCC)C(=O)NC[C@@H1](C)NC1=NC=NC(Cl)=C1C(C)=O CC(C)[C@H1]1CC[C@H1](C(=O)NC[C@H1](O)C(N)=O)N1C(=O)CCCOC(C)(C)C COC1(C2CC2)CN(C(=O)C[C@@H1]C3N(C(=O)C4=CC=C5C=CC=NN45)C(C)(C)C3)C1 COC1=CN=CC(C(=O)N(C)CCCC(=O)N[C@H1]2CC[C@H1]3CC[C@@H1]23)=C1 CN1N=C(C(F)F)C=C1C(=O)N2CCC[C@H1](CCNC(=O)/C=C/C(C)(C)C)CC2 O=C([C@H1]1CCCSC1)N2CC[C@H1]2C3=CN(CC4CCOCC4)N=N3 C[C@H1](NC(=O)C(C)(C)CS(C)(=O)=O)[C@@H1]1CCN(C(=O)C[C@@H1]2NC(=O)NC2=O)C1 CCOC(=O)[C@H1](CC)NC(=O)C1(F)CN(C(=O)[C@H1](F)CCC(C)C)C1 C=C[C@H1](C)C(=O)N1CCC([C@@H1]2CCN(C(=O)[C@H1]3C[C@H1]4[C@@H1](C3)C4(F)F)C2)CC1 CC/C(C)=C/C(=O)N1CCC2(CCC(NC(=O)C3=C[C@@H1](O)CCC3)CC2)CC1 CC1=NO[C@@H1](C(=O)N2CC(C[C@H1](C)NC(=O)CCCN3C(O)=NN=C3O)C2)C1 CCC[C@@H1](C)CC(=O)N1C[C@H1]2[C@H1](CNC(=O)CC3=CC(C)=NO3)[C@H1]2C1 CN1C=NC2=C(NCC3=CC=NC=C3)[NH1]C(=N[C@@H1]4CCC[C@@H1](C(C)C)C4)N=C21 C[C@@H1](NC(=O)C1=CC=CC=C1Cl)C(=O)N2C[C@H1]3CC[C@H1]2CN3C(=O)C4[C@H1]5COC[C@H1]45 CC1=NC=C(C(=O)NCC[C@]2(O)CCCN(C(=O)[C@@H1]3CCCOC3)C2)C=C1C#N C[C@H1](C(=O)N1C[C@@H1]2[C@@H1](C[C@H1]2NC(=O)C3CCCC3)C1)C4=CC=C(N(C)C)C=C4 CCN(C(=O)C=1C=NN(CC(C)C)C=1C)[C@@H1](C)CNC(=O)C(C)(C)C2CC2 C[C@H1]1C[C@H1](NC(=O)C2=C[NH1]C(=O)C3=CC=NN23)CN(C(=O)CC4=CN(C)N=N4)C1 C[C@@H1](CCNC(=O)C[C@@H1]1CC[C@@H1](C)CO1)NC(=O)C2=CC=CC=3N=C(CO)[NH1]C2=3 CC1=CC(=O)C(C(=O)NC(C)(C)CNC(=O)[C@H1]2CCCN2C3=NC=CS3)=CN1C C[C@H1]1CN(CC2=CC=NC=C2)CCN1C(=O)C3=CC4=CC=NC=C4S3 C[C@@H1]1CCCCN1CC(=O)NC[C@]2(F)C[C@H1](CNC(=O)[C@@H1]3CC[C@@H1](C4CC4)C3)C2 COC1=CC=C(O)C(C(=O)N2CC[C@@](O)(CCNC(=O)C3(C)CC(OC)C3)C2)=C1 CCOC1=CC=CC=C1C(=O)NC[C@]2(CO)CCN(C(=O)[C@H1](O)CC(F)(F)F)C2 OCC1=C(CNCC2=NC=CN2C3CC3)C=CC4=CN=CC=C14 CC[C@@H1]1CN(C(=O)CCSCC(C)C)CC[C@@H1]1NC(=O)C2=C[NH1]C3=NC=CC3=C2 C=CCCO[C@H1](C)C(=O)N[C@@H1]1C[C@@H1]1CNC(=O)CC2=CC=CC(Cl)=C2 CCC=1C=C(C(=O)N2CC[C@@H1](C)N(C(=O)CN(C)C3CC3)CC2)OC=1CC CC[C@@H1]1CN(C(=O)C[C@H1]2CCN(C(=O)[C@@](C)(O)CCN(C)C)C2)CC(=O)N1 CC[C@H1]1CN(C(=O)[C@H1](C)CC2CCC2)C[C@@H1]1C(=O)N(C)[C@H1]3CC[C@H1]3O CNC(=O)C(C)(C)C(=O)NCCSCC(=O)N(C)[C@@H1]1CCN(C2CC2)C1 C[C@@H1](CC(=O)NC[C@@H1]1CC2(CO1)CN(C3=NC=CN=C3F)C2)C4=CC=NC=C4 C[C@@H1](C(=O)N1CCC2(CC1)CN(C(=O)C3=CC=NC=C3N(C)C)C2)[C@H1]4CCOC4 C[C@H1]1C[C@H1](NC(=O)C2COCCOC2)CCN1C(=O)[C@H1]3CC[C@H1](C4CCC4)CC3 CCOC1=NC(Cl)=CC=C1C(=O)N2CC(C)(NC(=O)[C@@H1]3C[C@H1]4CC[C@@H1]3C4)C2 CC1=CC=C(OCC(=O)NC[C@H1](NC(=O)C2CC2)[C@@H1](C)C(C)C)C(C)=C1 C=CC1(C(=O)NC2[C@H1]3CC[C@H1]2CN(C(=O)[C@@H1]4[C@H1]5CC[C@@H1](C5)C4(C)C)C3)CCC1 O=C(N[C@H1]1CCCC12CN(C(=O)C3(F)CC3)C2)C4=CC=CC(=O)O4 CCN(CC1=CC=CC(C2=CC=CC(C(=O)NC)=C2)=N1)[C@@H1]3CCS(=O)(=O)C3 CC[C@H1](CN(C)C)C(=O)N1CC[C@@H1](C(C)(C)C(=O)NCC2(C)CCCCCC2)C1 CN(C(=O)[C@H1]1CC[C@@H1](C(N)=O)O1)C2CN(C(=O)CC3=C[NH1]C=CC3=O)C2 COC1=CC(C(=O)N[C@@H1]2CCN(C(=O)CN(C)C(C)C)C[C@@H1]2C)=CC=C1C(N)=O CCC(F)(F)C(C)(C)C(=O)NC[C@@H1]1CCCN(C(=O)C2(C3=CC(C)=NO3)CC2)C1 CC1=CC(C(=O)N[C@H1](C)CC2CN(C(=O)C=3N=CSC=3C(C)C)C2)=NC=C1CO CON(C)C(=O)C1(NC(=O)C(C#N)CCCN2C(=O)C3=CC=CC=C3C2=O)CC1 CSCCCNC(=O)[C@H1](C=1SC(C(F)(F)F)=CC=1C)N2CCC[C@H1]2C(=O)OC C=CC[C@@](C)(O)C(=O)N1CC[C@@H1](CNC(=O)C2=CN=C3N2CCOC3)C1 CCC[C@H1](NC(=O)CC=1C=CSC=1Br)C2=CC=CC(C(F)(F)F)=C2 C[C@H1](SC1=CC=C(F)C=C1)C(=O)NC[C@@H1]2CCCCN2C(=O)C3(F)CCC3 C#CC[C@](C)(NC(=O)[C@@H1]1CCNC1=O)C(=O)N2CCC3(CCCC3)C2 CC1=CC=C(S(=O)(=O)NCC2=CC(Cl)=C(Br)C=N2)C=C1 C#CC1(C(=O)NC[C@@H1](NC(=O)C=CC2=CC=C(CC)C=C2)[C@H1]3CCOC3)CCC1 C[C@H1](OC1=CC=CC=C1Cl)C(=O)NCC2(NC(=O)CC3C[C@H1]4C[C@@H1]4C3)CCCC2 CN(CCOCCNC(=O)C12CCC(CC1)C2)C(=O)C3=CC=CC=4N=C(O)OC3=4 CCC=1C=NSC=1C(=O)N(C)CC2(CNC(=O)[C@H1](C)CN3C=CC=N3)CC2 CC[C@H1](CC(=O)N[C@](C)(CO)CNC(=O)C1=CC=C2N=NN(C)C2=C1)C3CCC3 C[C@]12COC[C@@]1(C)CN(C(=O)[C@@H1]3CCN(C(=O)C4=CC=CC(O)=N4)C35CC5)C2 NC1=CC(C(=O)N2CC3(CCN3C(=O)C4=CCCOC4)C2)=NC=C1Cl CCC1=NOC(C(=O)N[C@H1](C)C2(O)CN(C(=O)C3=CC(C4=CC=CO4)=C[NH1]3)C2)=N1 CN(CCOCCCNC(=O)CC1CC(F)C1)C(=O)[C@@H1](F)CC2CC2 COC1=CC=C(CNC(=O)CN(C)C2=CC(I)=CC=C2Br)C(OC)=C1 C=C1CN2C(=NN=C2C(=O)N[C@H1]3COCCN(C(=O)[C@H1](CC)OCC)C3)S1 CC1=CC(C(=O)NC2CN(C(=O)[C@]3(C)C[C@@]3(F)Cl)C2)=C4C=CC=CC4=N1 CC[C@@H1](CN(C)C(=O)C=CC1=NC=CS1)NC(=O)C2=CC(F)=CC(OC)=C2 CC1=CC(C)=C(N)C(C(=O)NC2=NC(Cl)=C(C)N=C2C)=C1 C[C@H1](NC(=O)C1=CC=C2C(=C1)B(O)OC2)C(C)(C)NC(=O)CN3N=CC=CC3=O CC1=C(Cl)C=CN=C1C(=O)NC[C@]2(O)CCN(C(=O)C[C@@H1](C)CN(C)C)C2 CC1=CC(C(=O)N2CC[C@]3(C(=O)NC[C@H1]4CCCCS4)C[C@H1]3C2)=C(C)C=N1 CC(Cl)(Cl)C(=O)N[C@@H1]1CCC[C@H1](NC(=O)C=2SC=NC=2C3CC3)CC1 C=C1CC(CC(=O)N2CC[C@@H1](C)[C@@H1](CC(=O)N3CCC4=C[NH1]N=C4C3)C2)C1 C#CCNC(=O)CC(=O)N(C)C[C@H1](O)CNC(=O)C1=CN(CC2(C)COC2)N=N1 CC1=CC=C(N)C(C)=C1C(=O)NCCCC(C)(C)NC(=O)C=CC2CCC2 N#CC1=CC=C2C=C(C(=O)N3C[C@@H1]4CC[C@H1](C3)N4C(=O)[C@@H1]5[C@H1]6CC[C@H1]65)[NH1]C2=C1 CC[C@@H1](CNC(=O)C1=C(C(F)(F)F)C=C(C)N=C1O)NC(=O)C[C@H1](C)CF C#C[C@@H1](C)NC(=O)C1=NO[C@H1](CNC(=O)CN2C[C@H1]3CC[C@H1]2C3)C1 C=C(Cl)CCC(=O)N[C@H1](CC=1C=N[NH1]C=1)C(=O)N2C[C@@H1](C)OC(C)(C)C2 C[C@H1](CC(=O)N1CC=C[C@H1]1CNC(=O)C2=COC(C(F)(F)F)=C2)NC(N)=O CC1(C)CN(C(=O)C2=CC=CN=C2S)C[C@@H1]1CNC(=O)C3=CC=CN4N=NN=C34 CCC[C@@H1](NC(=O)C1=CC(C)=CC=C1NC(=O)C(C)C)C(=O)OC CO[C@@H1](CCNC(=O)[C@H1]1CCC[C@H1](C#N)C1)C(=O)NC2=C(F)C=CC=C2C#N CS[C@@H1](C)CCC(=O)NC[C@@H1]1C[C@@H1](C)CN(C(=O)C2=CC=CC(=O)N2C)C1 CCC1(C)CC(C(=O)N[C@@H1](C)[C@@H1](CO)NC(=O)C(C)(C)CC(=O)OC)C1 C[C@@H1](NC(=O)[C@H1]1C[C@@H1]1C2CN(C(=O)C=3C=C(CO)[NH1]N=3)C2)C=4C=CSC=4 CC=1ON=CC=1S(=O)(=O)N2CC(CC(=O)NC3=CC=CC(N4C=CN=N4)=C3)C2 CN(C)S(=O)(=O)CC(=O)N1CC2(CC2)C[C@@H1]1CNC(=O)C[C@@H1]3CCC3(F)F CCC(CC)C[C@@H1](F)C(=O)N1CCC2(CC2)C[C@H1]1C(=O)NC3=CN(C)N=C3C CC(C)CCC[C@H1](C)C(=O)NC[C@H1]1C[C@@H1](C(=O)N2CC=CC23CCCCC3)C1 CC1=NC=C(C(=O)O)C(C)=C1S(=O)(=O)N(C)CCCN(C)CCO CC(C)/C=C/C(=O)N[C@H1]1CC(F)(F)C[C@H1]1NC(=O)[C@]2(F)CCS(=O)(=O)C2 CCN1N=C(C(=O)N2CCC[C@](F)(CNC(=O)[C@@H1]3CC3(F)F)C2)C=C1O C[C@@H1](CCC(=O)NCCC1=NN=CS1)NC(=O)C23CCC(CC2)CC3 CCCC[C@H1](O)[C@H1](C)C(=O)N[C@]1(C(=O)NC[C@@H1](CO)CC2CC2)CCC(C)(C)C1 C[C@H1](NC(=O)NCC[C@H1]1CCCS1(=O)=O)C2=NC=CS2 NC(=O)C1(C(=O)N2CC(CNC(=O)[C@@H1](O)CCC3=CC=CC=C3)(C(N)=O)C2)CC1 CCCC1CC(C(=O)N2[C@H1]3CC[C@H1]2CC(C(=O)N4CCCNC(=O)C45CC5)C3)C1 CSC[C@@H1](C)C(=O)N(C)C[C@@H1]1CCCN1C(=O)C2=CC=C(OCC(C)C)N=C2 C[C@@H1](C(=O)NC[C@]1(O)CCCN(C(=O)C[C@@H1](C)CCC2=CC=CC=C2)C1)N(C)C COC(=O)[C@H1]1COC2(C1)CN(C(=O)[C@@H1](O)[C@H1](C)C3=CC=C(C)C=C3)C2 CN(C[C@@H1]1COC(=O)N1)C(=O)CCC2(NC(=O)[C@H1]3C[C@@H1]3C(C)(C)C)CCC2 O=C(CCCC1=CN=CS1)N[C@@H1]2C[C@H1]2NC(=O)C[C@H1]3CCC4=CC=CC=C4C3 COC(=O)C=1SC(N2CC(C[C@H1](C)NC(=O)[C@@H1]3O[C@H1](C)C[C@@H1]3C)C2)=NC=1Cl CC1=CC=C2C(=C1)CC[C@@H1]2C(=O)N3CCC[C@@H1]3[C@@H1](C)NC(=O)CCS(N)(=O)=O CC1=NN(C2CC2)C=C1C(=O)N3C[C@@H1]4CN(C(=O)C#C[C@H1]5CCOC5)C[C@H1](C3)O4 C=C[C@](C)(O)C(=O)N1C[C@H1]2[C@H1](CN(C)C(=O)C=3C=CC4=NON=C4C=3)[C@H1]2C1 O=C(CC1=CC=CC(Cl)=C1)N[C@@H1]2C[C@H1]3C[C@@H1](C2)N(C(=O)[C@@H1]4CN5CCC4CC5)C3 COCC1=N[NH1]C(=NC[C@H1]2CCCCN(C(=O)C=3[NH1]C(C)=C([N+1](=O)[O-1])C=3C)C2)S1 CCC[C@@H1](C(=O)N[C@H1]1CCCCC[C@H1]1C(=O)NCC2=CC(OC)=CC=N2)C(C)C NC1=CC(F)=CC(C(=O)N[C@@H1]2CCOC[C@@H1]2NC(=O)COC3=CC=C(F)C=N3)=C1 CC1(C)NC(=O)O[C@H1]1CNC(=O)[C@H1](CC2CC2)NC(=O)CCCN=[N+1]=[N-1] C[C@@H1]1CCC[C@]1(NC(=O)CN2CCOCC2)C(=O)N3CCOC4(CC4)C3 C[C@H1](O)C1CCC(NC(=O)C2=CSC(CNC(=O)C[C@H1](O)C3CCCC3)=C2)CC1 CCCN1N=NN=C1[C@]2(NCC=CCCOC)CCN(C(C)C)C2 C#CCO[C@@H1](C)C(=O)N(CCNC(=O)CS(=O)(=O)NC1CC1)CCSC CN(C)C[C@@H1](NC(=O)C12CCC(C1)C2)C(=O)N[C@H1](CCO)C3CC3 CCCC[C@@H1](CC)C(=O)N(C)C1CN(C(=O)C=2OC=CC=2CN(C)C)C1 C=CCCC1(C(=O)N2CC[C@@H1](O)C[C@@H1](C)C2)CN(C(=O)CCCCCOC)C1 CC1(NC(=O)C2=NOCC2)CCC(NC(=O)[C@H1]3CCCC=4SC=NC=43)CC1 COC[C@H1](CO)NC(=O)[C@]12CCC[C@H1]1N(C(=O)C3=CC(C#N)=CC=C3N)CC2 C#CCCC[C@H1](C)C(=O)N[C@H1](CN1C=CN=N1)C(=O)N(C)C[C@@H1]2C[C@@H1]2C C=CCC1(C(=O)N[C@@H1](CNC(=O)C2=CC=C3N=CSC3=C2)C4CCCC4)CCC1 CCCCONC(=O)[C@@H1]1C[C@H1](NC(=O)C[C@]2(O)CCCOC2)C13CCC3 CC[C@H1](OC)C(=O)N[C@H1]1CC[C@H1]1CNC(=O)C2=CC3=C(C=CC4=CC=CC=C43)[NH1]2 COCC1=NC(CC(=O)N[C@@H1](C)[C@@H1](C)NC(=O)C2=CC=CC=3N=C(O)OC2=3)=CS1 CN(CCOCCCN(C)C(=O)[C@]12CCC[C@H1]1C2)C(=O)C=3C=CN(CC(F)F)N=3 CCCCCCNC(=O)[C@@H1]1[C@H1]2CN(C(=O)CCC(=O)N(C)C)C[C@H1]21 CN(CC1CCN(C(=O)[C@H1]2CC23CCSCC3)CC1)C(=O)C4=CC(Cl)=CN=N4 COC1=CC=C(C)C=C1NC(=O)[C@H1](NC(=O)C[C@H1](C)N2C=CC=N2)C3(C)CC3 CC1=CC=C(C(=O)N2C[C@@H1]3C[C@]3(CNC(=O)C4=CC=C([C@@H1]5CCCO5)[NH1]4)C2)N1C CC1=NC=C(Br)C=C1C(=O)NC2C[C@@H1]3CC[C@H1](C2)N3C(=O)C4=CC=C(Cl)N=N4 COC[C@@H1](C)C(=O)N1CCC[C@@H1](CCNC(=O)C2CCC(CCO)CC2)C1 CC[C@@H1](NC(=O)[C@H1]1C[C@@](C)(NC(=O)C2C3(CC3)C24CC4)C1)C=5N=C[NH1]N=5 C[C@@H1](CN1CCCCC1)NC(=O)NC[C@H1]2CCCOC2 O=C(O)[C@H1]1C[C@](O)(CNCCSC2=CC=C(F)C=C2)C1 CC(C)(C)C[C@H1](O)CC(=O)NC/C=C/CC(=O)N1CCO[C@@H1](C2CCC2)C1 CC=1C=CC(=N)[NH1]C=1C(=O)N2CC[C@H1](C)[C@@H1](NC(=O)CN3C=C(CO)N=N3)C2 CC1=CN=C(C(=O)N[C@H1]2CN(C(=O)CC/C=C/C(C)C)CC[C@@H1]2C)C=C1C CC[C@H1](C)[C@H1](NC(=O)C=1N=CN(C)N=1)C(=O)N[C@H1](C)CC=2C=NN(C)C=2 CC1=CC=CC=C1NC(=O)[C@@H1]([C@H1]2C[C@H1]3CC[C@H1]2C3)N(C)CCC4=CC=CC=C4C CC[C@H1](C)CCCC(=O)N[C@H1](CO)CNC(=O)CC1=C(Cl)C=CC=C1OC CC(C)CCO[C@@H1](C)C(=O)N[C@@H1]1[C@H1]2C[C@@H1]1N(C(=O)C3=NOC(C)(C)C3)C2 C[C@@H1](CN(C)C)C(=O)N[C@H1]1C[C@H1](CNC(=O)C(C#N)=CC2CC2)C1 COC[C@@H1](C)C(=O)NC1CC(NC(=O)C2=CC=CN=N2)C1 C[C@H1](OC1=CC=C(Cl)C(Cl)=C1)C(=O)OC[C@@H1](C)C(=O)C2=CC=CC=C2 CSCC[C@H1](O)C(=O)N1CCN(C(=O)C2=CC(C#N)=NO2)C[C@H1](O)C1 CCCN1C=CC(C(=O)N2CC[C@H1](C)[C@H1](CNC(=O)C3COC3)C2)=N1 CCC(C)(C)CC(=O)NCC1(CN(C)C(=O)COC2=CC=CC(C)=C2C)CC1 CN(CCCCNC(=O)C[C@H1]1CCCC2(CC2)C1)C(=O)[C@@]3(C)CCC(=O)C3 CN1N=C(C(=O)NC2C[C@@H1]3C(NC(=O)CC4=CC=C(F)N=C4)[C@H1]3C2)C=C1O CCCN(C(=O)CCN1C=CC=NC1=O)C2CCN(CC3CC(C)C3)CC2 COC1=CC=C([C@@H1]2CN(C(=O)CCSC)CCN2C(=O)[C@@H1]3C[C@H1](F)C(=O)N3)C=C1 CO[C@H1](C(=O)NC1CCCN(C(=O)CSCCN(CC)CC)CC1)[C@@H1]2CCOC2 C[C@@H1](C(=O)N1CCC(C(C)(C)CNC(=O)C[C@@H1](C)F)CC1)N2CCN(C)CC2 O=C(NCC1CN(C(=O)CC2=CC=CC=C2OC(F)(F)F)C1)[C@@H1]3C[C@H1]4CC[C@@H1]3O4 C#C[C@@H1](NC(=O)[C@H1](CC(=C)Cl)NC(=O)[C@@H1](C)C1CCCCC1)C(C)(C)C NC(=O)C[C@@H1](O)C(=O)N1CC[C@@](CF)(NC(=O)[C@@H1]2[C@H1]3CC[C@H1]4[C@@H1](C3)C[C@H1]42)C1 CC(C)[C@@](C)(CNC(=O)C(N)=O)NC(=O)CCC1=N[NH1]C2=C1CCCC2 O=C(NCC[C@H1]1CN(C2=NC(Cl)=NC3=CC=C(Cl)C=C23)CCO1)C4=CN=N[NH1]4 C=CC[C@H1](CC(=O)NCC[C@H1](OC)C(C)C)NC(=O)[C@H1]1CCCC[C@@H1]1O CC(C)C1=CC=C(CCN=C[NH1]C(=NCC2=NC=CC(O)=N2)C(C)(C)C[NH1])C=C1 O=C(NC[C@@H1]1C[C@H1]1NC(=O)[C@@H1]2[C@H1]3CCCCC[C@H1]32)C=4C=CN5C=4CCCC5 CC=1[NH1]C=CC=1C(=O)N[C@]2(CO)CCCN(C(=O)C3(C)CCC(F)(F)CC3)C2 CCC1=NC=NC=C1C(=O)N[C@@H1](C)[C@@H1]2CCN(C(=O)C3=COC=C3C)C2 O=C(NC1=CC=C([C@H1]2CCCN2)C=C1)C(=O)NCCC3=C[NH1]C4=CC=C(F)C=C34 O=C(NC[C@@H1](O)C1=CC=C(OCC(F)(F)F)C=C1)NNC2=CC=C(Cl)C=N2 C=C(C)[C@@H1](CC(=O)N1CCC(N(CCO)C(=O)CCC[C@H1](C)CC)CC1)OCC O=C(CCCCC1=CC=CC=C1)N[C@H1]2COC[C@H1]2NC(=O)C[C@H1]3CCCCO3 CN(C(=O)C12CC(C)(C1)OC2(C)C)[C@H1]3CCC[C@@H1](N(C)C(=O)C45CCC(C4)C5)C3 C[C@H1](NC(=O)COC1=CC=C(F)C(F)=C1)C2=CC=C(N3CCCCC3=O)C=C2 COC[C@H1](O)CNC(=O)[C@]1(C)CC12CCN(C3=CC=NC(C)=N3)CC2 O=C(C[C@H1]1CCCOC1)N[C@@H1](CC(=O)N2CC3(CCC3)C24CCC4)C(F)F C=C[C@@](C)(O)C1=CN(C2=CC=CC=C2C(=O)N[C@@H1](C)C3CC=CC3)N=N1 CC[C@@H1]1CCC[C@@H1]1C(=O)NC[C@@H1]2CC[C@@H1](C)N(C(=O)CCC(=O)NC)C2 CN1N=CC(Br)=C1CN2CC[C@H1]3CN(C(=O)C4=CC=C(O)C=C4Br)C[C@H1]3C2 CCC(CC)NC(=O)C1=CC(CNC(=O)[C@@H1]2CN(C)C[C@H1](C)O2)=NN1C C[C@@H1](C[C@@H1](C)NC(=O)C1=CC2=C([NH1]1)CCCC2)NC(=O)C=3C=CC4=NC=NN4C=3 CS[C@H1](C)C(=O)NCC1=CC=C2C(=C1)CCN(C(=O)C=CC3=NC=CC=C3C)C2 CC[C@H1](O)C1=CN(C2CCN(C(=O)CCN(C)[C@H1]3CCOC3)CC2)N=N1 CN(C)CCC=1N=C(C2=CC=C(CCF)C=C2)N(C3=CC=C(C(C)(C)C)C=C3)N=1 CC(C)CC(CC(C)C)C(=O)N[C@@H1]1CCN(C(=O)[C@H1]2CC23CCC4(CC4)CC3)C1 COC1=CC=C(C)C=C1C(=O)N2CCC(CN(C)C(=O)COCC(F)(F)F)CC2 CCCOC1=CC=C(C(=O)COC(=O)C=2C=CN(CC3=CC=CC=C3)C=2)C=C1 CC1=CC(O)=C(Cl)C=C1C(=O)NCC[C@@H1]2CCCCN2C(=O)[C@@H1](C)[C@H1](O)C(C)C CC=1OC=C(C(F)(F)F)C=1C(=O)NC[C@H1](NC(=O)C2(O)CCCC2)C(C)(C)C C=C[C@H1](OC)C(=O)N[C@@H1](C)CNC(=O)C1=CN2N=CC=CC2=N1 CC(C)CC(=O)NC[C@@H1]1CN(C(=O)CNC(=O)N[C@@H1](C)C2=CC=CO2)CCN1C CC(C)CC(=O)N1CCC2(CCC2)[C@H1](NC(=O)CS(C)(=O)=O)C1 COC1=CC=CC=2C(CC(=O)N[C@@H1](C)[C@@H1](CO)NC(=O)C(C)(C)SC)=COC1=2 CC1=CC=C(C(=O)NC2(CO)CN(C(=O)C3CCCCC3)C2)C(N)=C1F O=C(NCCCN1CCOC1=O)[C@H1]2CCOCCN2C(=O)C3=CC=CN=N3 O=C(N[C@@H1]1CC[C@H1]1CNC(=O)[C@@H1]2CC23CCCCC3)C4(CC5=CC=CC(Cl)=C5)CC4 C#CC1=CN=CC(C(=O)NC[C@@H1](C)NC(=O)C2=CC=CC(N(C)C)=C2)=C1 C#CC[C@](C)(CC)C(=O)N[C@H1]1C[C@@H1](CCC(=O)N[C@H1](C)CN2CCCCC2)C1 CC/C(C)=C/C(=O)NC12CCC(CC1)N(C(=O)[C@H1]3CS(=O)(=O)CCO3)C2 C=C[C@](C)(O)C1=CN(C[C@@H1]2CCCN(C(=O)C3=CC(C4CC4)=NS3)CC2)N=N1 C=C[C@@](C)(CC)C(=O)NCC1=CC=C2C(=C1)CC[C@@H1]2NC(=O)CS(C)(=O)=O CNC(=O)CCC(=O)NCCOCCNC(=O)CNC(=O)C1=CC2=C(S1)CCC2 COCCN1C=CC(C(=O)NC[C@H1]2C[C@H1]3CC[C@H1]2N3C(=O)C=4SC=CC=4C#N)=N1 CCN1CCN(C(=O)[C@]2(C(C)C)CCN(C(=O)[C@@H1]3[C@H1]4CCCO[C@H1]43)C2)CC1 COC(=O)N(C)CC(=O)NC1=CC=CC(CNC(=O)C=2C=CN(C)C(=O)C=2)=C1 CC[C@H1](C)[C@H1](O)[C@H1](C)C(=O)N1CC=CC[C@@H1]1C(=O)N2C[C@@H1]3CC[C@]3(C)C2 C[S@@](=N)(=O)C=1C=NN2C=1CN(C3=NC=NC4=C3N=CN4CC5(O)CSC5)CC2 C=C[C@@](C)(CC)C(=O)NCCC1(OC)CN(C(=O)C=CC2=CC=CC(Cl)=C2)C1 COCCN(C(=O)CCN1CC2=CC=CC=C2C1=O)[C@H1]3CC[C@H1](C)C3 CN1N=CC=C1C2(C(=O)NC[C@H1](O)CNC(=O)C3=CC(Cl)=C4C(=C3)OCCCO4)CC2 C#CC[C@@]1(C(=O)N[C@@H1]2CC[C@H1](NC(=O)CC3=CC=CC=C3C)C2)CCCCO1 C[C@@H1](NC(=O)[C@H1]1C[C@H1](O)C1)[C@H1](NC(=O)C2=CC(F)=C(F)C(C#N)=C2F)C3CC3 CCCC(F)(F)C(=O)NCC(C)=CC(=O)NC1(C)CC2(CCC2)C1 CC(C)COCC(=O)N[C@H1]1COCCN(C(=O)[C@H1]2CCOC3=CC=C(Cl)C=C32)C1 CC1=CC=C([C@@H1](C)N=C2N=C3C(C=NN3C)=C(N(C)C[C@@H1](C)C(F)(F)F)[NH1]2)C=C1 C#CCOCCC(=O)NC[C@@H1]1CCCC[C@@H1]1NC(=O)CN2C=NC(C(=O)OC)=C2 COC(=O)CC(C)(C)CC(=O)NC[C@@H1]1CCN1C(=O)C(=O)N2CCC[C@H1](C)C2 CN(C)S(=O)(=O)C1(CNS(=O)(=O)CCC2=CC=C3C(=C2)CCO3)CC1 COC1=CC=C(CCC(=O)N[C@@H1]2CN(C(=O)C=3OC=CC=3Br)C[C@H1]2O)C(F)=C1 CCN1N=NN=C1[C@@H1](NCC[C@H1]2C[C@H1](C(=O)OC)C2)C(C)(C)OC3=CC=CC=C3 N#CC1=N[NH1]C(=NCC23CC(NC(=O)C4=NN=C5N4CCCCC5)(C2)C3)S1 COCCS(=O)(=O)CC(=O)NC1(CCCNC(=O)[C@H1]2CO[C@H1](C)C2)CC1 CC1=C([C@H1]2[C@H1](C=NC=C3CC(Cl)=CN3C(C)CC4CCC4)CC(=O)N2)C=NN1C CSC=CC(=O)NC[C@@H1](NC(=O)C1CN(C(C)=O)C1)[C@H1](C)C(C)C CCN1C(=O)CC[C@@H1]1CC(=O)NC[C@@H1](C2CC2)N(C)C(=O)C3=CC=NN3C(C)C C[C@@H1](CCNC(=O)C1=CC(Cl)=C(Br)S1)NC(=O)[C@@H1]2C3C[C@@H1]4C2[C@@H1]4C3 FCCN=C1[NH1]C2=C(C(=NCC3=CC=CC(OCC(F)(F)F)=C3)[NH1]1)CCC2 CCC1=CC=C(C(=O)N[C@H1]2C[C@@H1](NC(=O)C3=CC=C(CS(C)(=O)=O)O3)C2)[NH1]1 C[C@@H1](CCN=C1N=C(C(C)(C)C)[NH1]S1)NC(=O)C=2C=C(C(F)F)N(C)N=2 CC1=CN(C(C)(C)C(=O)N[C@@H1](C)CNC2=NC=CC(S(C)(=O)=O)=N2)C=N1 CC1=CC(C(=O)N[C@]2(CO)CCN(C(=O)CN3CCC(C)CC3)C2)=C(O)N=N1 C#CCCCC(=O)N1CCN(C(=O)CC2=CC=C(S(=O)(=O)CC)C=C2)[C@H1](C)C1 C#C[C@H1]1[C@H1](C(=O)N2CCC[C@H1](CNC(=O)/C=C/CCC=C(C)C)CC2)C1(C)C CCN1C=CC(C(=O)N2CC[C@H1](NC(=O)C3CC(C(F)F)C3)[C@@H1](C)C2)=C1C CCCN(CCNC(=O)[C@@H1]1CC12CCC2)C(=O)[C@@H1]3CCC4=CC=CC=C4C3 C[C@@H1]1CN(C(=O)C(C)(C)[C@@H1]2CCCO2)CC[C@@H1]1CNC(=O)C3CC4(CCO4)C3 CC(C)(C)C1(C(=O)N[C@H1]2CCC[C@H1]2NC(=O)C3=CC=CC(C#CCO)=C3)CCC1 COC1=NC(C)=CC(=N[C@@H1]2CC[C@]3(CCN(C(=O)C4(C5CC5)CCC4)C3)C2)[NH1]1 N#CC1=CC(C(=O)N[C@@H1]2CC[C@@H1]2NC(=O)CCOC3=CC=CC=C3F)=CC=C1Cl C=CCCOCCCCC(=O)N(C)[C@@H1](C)CNC(=O)[C@@H1]1C2C[C@@H1]3C1[C@@H1]3C2 C[C@@H1](C(=O)N1CC(F)(C#N)C1)[C@H1]2CCCN(C(=O)CN3C=NN=N3)C2 CN1C=NN=C1CCC(=O)N2CC[C@@]3(CCN(C(=O)CC4=CN=CC(Br)=C4)C3)C2 C[C@@H1]1CN(C(=O)CCCCCN(C)C(=O)C2=NC(Cl)=CS2)C[C@@H1]1N(C)C O=C(NCC[C@@H1]1CC(F)(F)CN1C(=O)CC2=CC=NC(Cl)=C2F)[C@@H1](O)C3CCC3 CCOC(=O)[C@H1]1CC[C@@H1](S(=O)(=O)CC2=CC=CC=C2F)C1 C=CCC[C@@H1](NC(=O)C1(C2=CC=CS2)CCCCC1)C3CC3 CC(C)(C)SCC(=O)N[C@@H1]1CS(=O)(=O)C[C@@H1]1NC(=O)C2=CN=NS2 CCO[C@H1]1C[C@@H1](NC(=O)[C@@H1](O)CCCNC(=O)[C@]2(C#N)CC23CCC3)C1 C#CCC(C)(C)C(=O)N[C@H1]1CC[C@H1](CNC(=O)C2=C[C@H1](C)C2)CC1 O=C(N[C@@H1]1COC[C@@H1]1CNC(=O)C2OCCCO2)C3=CSC(C=4C=COC=4)=N3 CCCC1=CC=C(C(=O)N[C@H1](C)CN(C)C(=O)[C@H1](C)[C@H1](O)[C@H1](C)CC)[NH1]1 COC1(CNC(=O)[C@H1]2C[C@H1]2F)CCN(C(=O)C3=NC=CC=4C=CSC3=4)CC1 CC[C@@H1]1CC[C@H1](C(=O)N2CCC[C@H1](CN(CC)C(=O)C3CC(F)(CF)C3)C2)O1 CCCC[C@H1](NC(=O)CC1(CSC)CC1)C(=O)N2CC(=O)NC3(CC3)C2 CC(C)(CCNC(=O)C1=CC=C(C2CC2)C=C1)NC(=O)C3=CN(C4CCC4)N=N3 CCC=1N=N[NH1]C=1C(=O)NC[C@@H1]2CN(C(=O)C=3C=NN4C=3CCC4)CC[C@H1]2C C[C@H1](C(=O)N1C[C@@H1]2CC[C@H1](NC(=O)C3=CCCOC3)C[C@H1]2C1)C4=CC=CC(Cl)=C4 COC(C)(C)CCCCC(=O)N[C@H1](C)CC1CN(C(=O)[C@H1](C)OCCN(C)C)C1 CC=1SC(CC2=NOC(C3CC3)=N2)=NC=1C(=O)N[C@H1](C)C(=O)NC4=CC=CC=C4 N=C1N=NN(CC(=O)N2CC[C@H1](CO)[C@@H1](NC(=O)[C@@H1]3CCC(=O)N3)CC2)[NH1]1 CN(CC(=O)N[C@@H1]1C[C@]12CCN(C(=O)CCC(F)(F)F)C2)C3CCCC3 C=C[C@H1](OC)C(=O)N1CCOC[C@@H1](C(=O)NCC2=CN=CC(CC)=C2)C1 CCN1N=CC(C)=C1C(=O)NC[C@H1]2C[C@H1](F)CN2C(=O)C=CCN3CCOCC3 C/C=C/[C@H1]1CN(C(=O)CN2C=NN=C2O)C[C@@H1]1C(=O)N[C@H1]3CCC[C@@H1](O)CC3 CCN1CCC[C@H1](C(=O)N[C@H1]2CN(C(=O)COC3=CC(Cl)=CC=C3C)C[C@@H1]2C)C1 C=C(C)CN1N=NN=C1C2(NC3=CC=CC(Cl)=NC(C)=NN3)CC(C#N)C2 OCCCCN1N=C(C2=CC=CC(F)=C2)N=C1C3=CC=C4C=CN=CC4=C3 CCOC(=O)C=1C=NN(C)C=1C(=O)N[C@H1]2C[C@@H1]2NC(=O)C3=CN=C[NH1]3 CCOC1=NC=C([C@H1](C(=O)NC(C)C)N(CC)CCCC(F)(F)F)C=N1 O=C(N[C@@H1]1CCN(CC2=CC=C(I)C=C2O)C1)C3=CC([N+1](=O)[O-1])=C(Cl)C=C3Cl CO[C@]1(C(=O)N[C@@H1]2CCC3=CC(CNC(=O)C4(F)CC4)=CC=C32)CCS(=O)(=O)C1 C[C@@H1]1OC2(C(=O)NCC3(NC(=O)C4=CN=C(S)N4C5CC5)CCCC3)CC1C2 COC1=C(F)C=CC(F)=C1C(=O)N2CCCO[C@H1](CNC(=O)C(=O)C(C)(C)C)C2 C#CCOCCC(=O)N1CC[C@@](C)(C2=CN(CCCCC(=O)OC)N=N2)C1 O=C(COC1=CC=CC=C1)NC2CC3(C2)C[C@@H1]3NC(=O)[C@@]4(F)CCOC4 C#CCOCCC(=O)N1CCC[C@@H1]2CCN(C(=O)C=CC3=CN=CS3)C[C@@H1]21 CC(C)C[C@@H1](C(=O)NCCCN1CCOCC1)N(C)C(=O)[C@@H1]2CC(=O)OC2(C)C C[C@@H1](CCNC(=O)C(F)(F)[C@@H1](C)O)NC(=O)CC1=CC=C2N=C[NH1]C2=C1 CC(C)(C)COCCC(=O)N[C@H1](CCOCCO)C(=O)N[C@@H1]1COCCC1(F)F CCCC[C@@H1](CNC(=O)[C@H1]1C[C@H1]1C(F)F)NC(=O)C2=NC=CN=C2C(F)(F)F C[C@H1](CO)C(=O)N[C@H1]1CC[C@@H1](N(C)C(=O)C=2C=C(C(F)F)ON=2)CC1 COC(=O)C1=CC=CC(C(=O)NC[C@H1](NC(=O)C2=CC=C[N+1]([O-1])=C2)C3CC3)=C1C C=CC1(C(=O)NC2[C@@H1](N(C)C(=O)CC3=CSN=C3C)C4(CC4)C2)CCC1 C/C=C/CCCCC(=O)N1CCC[C@H1](CCNC(=O)CCO[C@H1]2CCOC2)CC1 CC1=N[NH1]C(C)=C1SCC(=O)N[C@@H1]2CC[C@@H1](CCNC(=O)C34CCC(CC3)C4)C2 CCC(CC)(CCC(=O)NC1CCC(NC(=O)CCCC2CC2)CC1)[N+1](=O)[O-1] CC(=O)NC1(C(=O)NCC2=CN(CCNC(=O)C[C@H1]3CCOC3)N=N2)CCCC1 CC1CN(CC(=O)N2CCCCC[C@H1]2CNC(=O)C3=CC=CC=4SC=CC3=4)C1 C[C@@](O)(CNC(=O)C1CCCC1)[C@H1]2CCCN(C(=O)C3=CC(Cl)=C(N)C=C3F)C2 O=C(CC1=CC=C(Cl)C=C1F)NCCOC2CN(C(=O)C34CCN(CC3)C4)C2 C=C=C(C)CC(=O)N[C@@H1]1CC[C@@]2(CCN(C(=O)C=3C=COC=3I)C2)C1 CC=1[NH1]N=C(C(=O)NC[C@@H1](NC(=O)C2(OC=3C=NN(C)C=3)CC2)C4CC4)C=1O C[C@@H1](O)C(=O)NCC1=CN(C2(C(=O)N3CCC[C@H1]3C)CC2)N=N1 COCC1(NC(=O)C=C2CCCC2)CN(C(=O)C3=CC(Br)=CC=C3C4CC4)C1 O=C(C[C@H1]1CCC[C@@H1](NC(=O)C2=CC=C3C(=C2)CCC3)C1)NC[C@@H1]4CCOC4=O CN1C=CC=C1C(=O)N2CCC[C@H1]3CN(C4=NC(Cl)=NC=C4[N+1](=O)[O-1])CC[C@@H1]32 C[C@H1](C(=O)C1=CC=CC=C1F)N2CCO[C@](CN)(C(F)F)C2 COCCN(CCNC(=O)C(C)(C)COC)C(=O)C1=NC(C(F)(F)F)=CC=C1N C=C(C)CCC(=O)N(C)CCOCCNC(=O)[C@@H1]1C[C@H1]2[C@@H1](C1)C2(F)F COC1=NC=C(C(=O)N2CC[C@@H1]3OCCN(C(=O)C4=NO[C@@H1](C)C4)[C@@H1]3C2)C=N1 CC1(C)C[C@H1](CC(=O)N[C@H1]2CCS(=O)(=O)C2)N(C(=O)[C@]34C[C@H1]3CNC4=O)C1 CC[C@H1](CC(=O)N1CCC[C@@](COC)(NC(=O)CC2=CC=CC(OC)=C2)C1)SC C=C1CC[C@@H1]1C(=O)N2CC[C@@H1](CNC(=O)[C@@H1](C(C)C)N3CCCS3(=O)=O)C2 CC[C@@H1](C)N(C)C(=O)[C@H1]1CCCCN(C(=O)C2CN(C(C)=O)C2)C1 C=C[C@@H1](C)CC(=O)NC[C@@H1](NC(=O)C=1C=NN(C)N=1)C2=CC=CC=C2CC O=C(NC1=C(F)C=CC(F)=C1F)[C@H1]2C[C@@H1]3C[C@@H1]3N2C(=O)C4=CC(Br)=NC(Br)=C4 C=CC(=O)N[C@@H1]1CCCC[C@H1]1CNC(=O)[C@H1](C)N2C=NC=N2 C#CCC1(NC(=O)C2(CCC=C)CN(C(=O)C3=CC4=CC=CC=C4C3)C2)CCC1 FC1=CC=CC([C@@H1](NC2=CN=C(Br)C(Cl)=C2)C3=NN=NN3C4CC4)=C1 CC1=C(C(=O)NCCC[C@@H1]2CCCN2C(=O)[C@@H1]3CC4=NN=CN4C3)CCCO1 CN(CC1=NN=CN1C[C@H1](C(F)(F)F)C)C(=O)[C@]2(C(F)(F)F)CCO2 C[C@@H1]1NC(=O)O[C@]12CCN(C(=O)NCC(F)(F)C3=CC=CC(Br)=C3)C2 CC1=NC=C(CNCC2=COC3C=CSC23)N1C4=CC=C(Cl)C=C4 CC[C@]1(C)C[C@@H1]1C(=O)N[C@@H1]2CC[C@@H1]3CN(C(=O)[C@@H1](NC(N)=O)C(C)C)C[C@H1]3C2 C#CC1(F)CN(C(=O)[C@H1]2CCN(C(=O)C=3C=C(OC)N(C)N=3)C24CCC4)C1 CCN(CCNC(=O)C1=CC=C(OC2CC2)C=C1F)C(=O)CN(C)C(=O)OC CC(C)N1C[C@@H1](C(=O)NCC2CCN(C(=O)C3=CC=CC4=CN=CN34)CC2)CC1 CCN(CCNC(=O)C1=CC(C(=O)C2=CC=CO2)=C[NH1]1)C(=O)C3=CC=CN3C C[C@H1](C(=O)N1CCC(CNC(=O)CCCN=[N+1]=[N-1])(OC)CC1)N2CCOCC2 CO[C@@H1]1C[C@H1]2C[C@H1](NC(=O)[C@](C)(CSC)NC(=O)C[C@H1]3CC[C@H1](C)CO3)C[C@H1]21 CCC[C@H1](C)CC(=O)NC[C@@](C)(CO)NC(=O)C1=CC2(CCOCC2)C1 CC1=NC(NC(=O)[C@@]23C[C@H1]2CN(C(=O)C4=CC(Br)=CC=5C=N[NH1]C4=5)C3)=CS1 C#CC1(C(=O)N2[C@H1]3CC[C@H1]2CC(C[C@H1](C)NC(=O)[C@@]4(OC)CCSC4)C3)CCC1 NS(=O)(=O)CCC(=O)NCCCC[C@@H1](CO)NC(=O)[C@@H1]1C[C@H1]1C2=CC=CS2 CC(C)(C)[C@H1](CNC(=O)C1=CC=CC(=O)O1)C(=O)N2CC[C@H1](O)[C@H1](O)C2 CC1=CC(CCC(=O)N2C[C@@H1]3C[C@@H1]3[C@H1]2C(=O)N(C)[C@@H1]4CCOC(C)(C)C4)=N[NH1]1 CCCN(C(=O)C1=CC2=C[NH1]C=NC2=N1)[C@@H1]3CCN(C(=O)C4=CCCC[C@@H1]4C)C3 CC1=CC=C(C(=O)N2CCC[C@@H1](C)[C@H1]2CNC(=O)CN3CCN(C)CC3)O1 CC(C)OC1=CC=C(CCNC=2[NH1]C(=NC[C@H1](C)[C@@H1](C)O)N=C3SC=NC=23)C=C1 CN(C(=O)[C@@H1]1CCCC12CCC2)[C@H1]3C[C@@H1]4CC[C@H1](C3)N4C(=O)CC=C(Cl)Cl O=C1O[C@H1](CN=C(NC2CCCCC2)NCC[C@H1]3CC3(Cl)Cl)CN1C4CC4 NC(=O)[C@@H1]1CCN1C(=O)CC2(NC(=O)C3=CC(CO)=CC=N3)CCCCC2 COCC1=CC=CC=C1[C@H1](C(=O)NCCC#N)N2CCC[C@H1](C3=NC=CS3)C2 O=C([C@@H1]1C[C@@H1]2C=C[C@H1]1C2)N3C[C@@H1]4CCC[C@H1](C3)N4C(=O)C5=CC(Cl)=NC=C5F C[C@H1]1CCO[C@H1]1C(=O)N2CC=C[C@H1]2C(=O)NC3(C)CCSCC3 C[C@@H1](C(=O)NC[C@@H1]1C[C@H1](F)CN1C(=O)C2=CC(=O)C3=CC=CC=C3O2)S(C)(=O)=O C=CC[C@@H1](NC(=O)[C@H1](O)CNC(=O)C=1C=C(CC)SN=1)C2CC2 C1=CN=C2C(N3CC[C@@H1](OC4CCC4)C3)=NC(=NCC=5C=N[NH1]C=5)[NH1]C2=C1 CC[C@@H1]1[C@@H1](NC(=O)C2=CSC(C3=CC=CC=C3)=N2)CCN1C(=O)[C@H1]4CCN(C)C4 CC[C@@H1](C(=O)N1CCCC[C@H1]1CNC(=O)C2CCC(O)CC2)N(CC)CC C[C@@H1](CC(=O)C1=CC=CO1)NC(=O)[C@@H1](Cl)C2=CC=C(Cl)C=C2Cl FC1=CC=CC=C1[C@@H1](NC2=CC=C(Br)C3=CC=CC=C23)C4CCCC4 C[C@@H1](OCC1=CC=NC=C1)C(=O)N2C[C@@H1]3C[C@H1]2CN3C(=O)CN4CCCOC4=O COC1=CC(F)=C(C2=CC=C(S(=O)(=O)NCCCC[S@](C)=O)C(C)=C2)C(OC)=C1 CN(C(=O)[C@]12CSC[C@@H1]1C2)C(C)(C)CC(=O)N[C@]34CC[C@H1](C[C@@H1]3O)C4 C[C@H1](NC(=O)CCS(C)(=O)=O)[C@@H1]1CCN(C(=O)C=2C=NN(C)C=2C#N)C1 COC1=CC(Br)=C(CN2CC3(CC[C@@H1](C(=O)N4CCCC[C@H1]4C#N)O3)C2)C=C1O CC(=O)NCC(=O)N1C[C@@H1](NC(=O)C2=CC(C)=C(C)N=C2O)C(C)(C)C1 C=CCOCC(=O)NC[C@@H1](NC(=O)/C=C/C(C)(C)SC)[C@H1](C)C(C)C C#CCN(C)C(=O)C(=O)N1CC[C@H1](N)C2=CC=CC(F)=C21 C[C@@H1]1CNC[C@H1]1NC(=O)C=2C=C3C=CC=NN3N=2 O=C(N[C@H1]1COCC[C@H1]1C(=O)N2CC([C@@H1]3CCCO3)C2)[C@@H1]4CC[C@H1](C5CC5)C4 COC=1C=CC(=NC(=O)C(F)CCN(C(=O)C=2[NH1]N=C3N=CC=CC=23)CC)[NH1]N=1 CCCC[C@H1](O)CC(=O)NC[C@@H1]1C[C@H1]1CNC(=O)CC2(N3C=CC=N3)CC2 CC1=CC=CC=C1C(C)(C)C(=O)N2CC(O)(CCNC(=O)C3=NC(O)=C(C)S3)C2 CC1(C)C[C@@H1](O)CN1C(=O)[C@@H1]2[C@H1](O)CCN2CC3=CC=CC(O)=C3Cl COC1=CC(C(=O)N2CC[C@@H1](NS(=O)(=O)C3=CC=C(C)S3)C2)=CC=C1I COC1=CC=C(OCC(=O)N[C@H1]2CC[C@H1](NC(=O)C3=C[C@H1]4CC[C@H1]3C4)CC2)C=C1 O=C(CN1CCCS1(=O)=O)N[C@@H1]2CC[C@@H1]3CN(C(=O)C4=NN=CS4)C[C@H1]3C2 COC1=CN=CC(C=CC(=O)N2C[C@H1]3C[C@@]3(NC(=O)[C@H1](C)N4CCC4)C2)=C1 CC1=CC(C)=C(C)C(OCCC(=O)N[C@H1]2C[C@@H1](CNC(=O)C3=CC=CS3)C2)=C1 CN(C)C(=O)C1(C(=O)N2CCC[C@H1](CN(C)C(=O)[C@]3(C)CCCCO3)C2)CC1 CC/C=C/C[C@@H1](C)C(=O)N1CC[C@H1](CCC(=O)N[C@H1](CO)C(=O)OC)C1 COC1=CC(C(=O)NC2=CC=CC(NC(=O)C3=NC=C[NH1]C3=O)=C2)=NN1C C[C@H1](C(=O)N1CCC(C2CCN(C)CC2)CC1)C3CCC3 CC[C@@H1](C1C=CN(CC(=O)N(CCN(C)C)C2CC2)N=N1)C(=O)OC CCC(C)(C)N1N=NN=C1[C@@H1](NCCS(=O)(=O)CC)[C@@H1]2CC2(C)C CCCN(CCNC(=O)C1CCC=CCCC1)C(=O)C[C@H1]2CCCC[C@@H1]2C C=C[C@H1](OC)C(=O)N1CCC([C@@H1](C)C(=O)N2CCCC[C@H1]2CC(N)=O)CC1 CC1=CC(Cl)=CC(C(=O)N2CC(C)(NC(=O)CNC(=O)CC(C)(C)C)C2)=C1 CC=C(C)C(=O)NC[C@@H1]1CN(C(=O)CCCC2=C(F)C=CC=C2F)CCO1 CC[C@@H1](CC(=O)NCCCNC(=O)[C@@H1]1C[C@H1]1C2CCCCC2)OC CCC1=CC(C(=O)N[C@@H1](CNC(=O)C2(C#N)CCC2)C3CCCC3)=NN1CCO C[C@@H1](CO)N1CCN(C2=CC=C(S(=O)(=O)NC[C@]3(C)CC3(F)F)C(Cl)=C2)CC1 COC1=NC=C(C(=O)N2C[C@H1]3C[C@H1]2C[C@H1]3NC(=O)C(C)=C4CC4)C(C)=N1 CN1[NH1]C(C(=O)NC[C@@H1](CNC(=O)C(C)(F)F)C2=CC=CC=C2)=NC1=O COC1=CC=C(C(=O)N[C@@H1]2CC[C@H1]2CNC(=O)C3=C[NH1]C4=CC=CN=C34)S1 CC(C)[C@@H1]1[C@@H1](NC(=O)C2=CSC(Cl)=C2)CCN1C(=O)C3=CC=C(OC(F)F)C=C3 CCC[C@H1](CC(C)C)C(=O)N[C@H1](CC1CCOCC1)C(=O)NC[C@@](C)(O)CSC CSCC[C@@H1](CO)NS(=O)(=O)C1=CC=C(N[C@H1](CO)C[C@@H1]2CCOC2)C(Br)=C1 CCCCCC1=CC(C(=O)N2CCC(=CC3=CC=CC=C3C)CC2)=N[NH1]1 CC1=CC(C(=O)N2CCCC[C@@H1]2[C@H1](C)NC(=O)C3=CC=NC(C(C)(C)C)=C3)=NO1 CN1N=CC=C1C[C@@H1](NCC2=CC=CC(NC(=O)C3=CC=CO3)=C2)C(=O)O CCCCS(=O)(=O)N1CCC[C@H1](CNCC2=CC=3C=COC=3C=N2)C1 C=C1CN(C(=O)[C@@]23C[C@@H1](CCO2)N(C(=O)C4=CC(C)=NO4)C3)C1 CC(=O)NC1=CC=CC(C(=O)N[C@@H1]2CC23CCN(C(=O)[C@H1]4NC(=O)C[C@H1]4C)CC3)=C1 C#CC[C@H1](CC(=O)NCCC=1C=C(C)[NH1]N=1)NC(=O)[C@H1](O)[C@@H1](OC)C(C)C O=C(NC[C@@H1]1CN(C(=O)C2(C3CCC3)CC2)[C@@H1]4C[C@@H1]14)C5=CC([N+1](=O)[O-1])=N[NH1]5 CC(C)NC(=O)[C@H1](C)N1C=C(CN(C)CCN(C)C(=O)C2CCCCC2)N=N1 CO[C@H1](C(=O)N(C)C1(CC(=O)N[C@@H1](C)C2=CCN(C)CC2)CC1)[C@H1]3CCOC3 CC1=CC(C(=O)NC[C@H1](CO)CNC(=O)[C@@]23CC[C@@H1](C[C@H1]2F)C3)=CN1C(C)C CCC1(C(=O)N2CC3(CCN(C(=O)C4=CC=NC(OC(C)C)=C4F)C3)C2)COC1 CCN(CCN(CC)C(=O)[C@H1](SC)C(C)(C)C)C(=O)C=1OC=C2C=1CCOC2 CC#CCCC(=O)NCC=1OC=CC=1C(=O)N[C@H1]2C[C@@H1](O)[C@H1](F)C2 C[C@@H1](C(=O)NC[C@H1](O)CN(C)C(=O)C1=CC(Cl)=CC=C1O)C2=CC=NN2C C=CCC1(NC(=O)[C@@H1](C)NS(=O)(=O)CCC)CN(C(=O)C2=CSC=C2SC)C1 C#CC1=CC=C(OCC(=O)NCCCCCNC(=O)[C@@]2(C)CC2(C)C)C=C1 CCNC(=O)C(=O)NCC12CC(NC(=O)C3=CC=C([C@H1]4CCOC4)S3)(C1)[C@@H1](C)O2 C#CCC1(C(=O)N2CCC[C@H1](C3CCN(C(=O)[C@@]4(C)C[C@H1]4Br)CC3)C2)CC1 CC1=CC(C(=O)N[C@@]2(C)CCN(C(=O)[C@@]3(C)CNC(=O)C3)C2)=NN=C1C CC=C(C)C(=O)NC[C@H1]1CN(C(=O)[C@H1]2CC=CC3=CC=CC=C32)CCC1(F)F CC1=CC(Cl)=C(N)C(C(=O)NC[C@H1]2CCCN2C(=O)CC3=NON=C3C)=C1 CC1(C)CC(C(=O)NC[C@@H1](CO)CNC(=O)C2=CC=C(N3CC[C@@H1](O)C3)C=C2)C1 CC(=O)N(C)[C@H1](C)C(=O)N1CCC(NC(=O)[C@H1](C)SCC2=CC=CC=C2)CC1 COCCN(C)CC(=O)N1CC(C2CN(C(=O)C3=CC(O)=NC(N(C)C)=N3)C2)C1 CC[S@](=O)CC(=O)NC[C@H1](C)C(=O)NCC1=CN=N[NH1]1 CC1=C(C(=O)N[C@H1]2CCN(C(=O)[C@@H1](C)C(F)F)C2(C)C)C=CN1C(C)C O=C(N[C@H1](CO)CCCCNC(=O)C1(C2=CC=CC(F)=C2F)CCC1)C=3C=COC=3 CN1C=CN=C1[C@@H1]2CN(C(=O)CCN3C=CC=N3)C[C@H1]2NC(=O)[C@@H1](F)C(C)(C)O C[C@@H1]1CN(C)C(=O)CN1C(=O)[C@@H1](NC(=O)C=2C=C[NH1]C3=NC=CC=23)C4CCCC4 N#CC1=NN=C(N(CCO)[C@H1]2CCCN(C(=O)CC3(C4=CC=CC=C4)CC3)C2)S1 CCC(=O)N[C@@H1](C)C(=O)N[C@@H1]1CC[C@H1]2CCN(C(=O)C/C=C/C(C)C)[C@H1]1C2 C[C@@H1]1CC[C@@H1](CNC(=O)[C@@]23C[C@@H1]2CN(C(=O)[C@@H1]4CCCS4)C3)C1 COC1=CC(C(=O)N[C@H1]2C[C@H1](N=C3[NH1]C(Cl)=NC=C3C)C2(C)C)=CC(C)=N1 CCN1N=C(C(=O)N(C)CCCN(C)C(=O)CCC2=CN=CC=N2)CCC1=O CCC1=CN=CC=C1C(=O)NCC2CCN(C(=O)C[C@@H1]3CC[C@@H1](C)O3)CC2 CN(C)C(=O)NCCNC(=O)[C@@H1]1C[C@H1](F)CCN1C(=O)CC2=CC=C[NH1]2 CCN1CCC[C@@H1]1C(=O)NC23CCC(C(=O)N4CCC45CCCCC5)(CC2)C3 O=C(N=C1C=C[NH1][NH1]1)C2=CSC([C@@H1]3CCCN3C(=O)NCCC=4C=N[NH1]C=4)=N2 CC1=CSC(CC(=O)N[C@@H1](C)CCNC(=O)C2=CC=C([N+1](=O)[O-1])C(O)=C2)=N1 C#CCCN1CC[C@@H1]([C@@H1]2CCCN(C(=O)C=CC3=CC=CC=C3Cl)C2)C1 CCCC[C@@H1](O)C(=O)N1CCC[C@H1](CC(=O)NC2=CC=CC=C2SC)CC1 CC1=CSC(C(=O)N2CC(CCNC(=O)C3=CC=CC4=CC=CN=C34)C2)=C1Cl CC(C)C(C)(C)C(=O)N[C@H1]1CN(C(=O)C2(C3=CC=NO3)CCC2)CC[C@H1]1C(F)F CC[C@@H1](CN(CC)C(=O)C=1OC(SC)=CC=1C)NC(=O)[C@@H1]2CCS(=O)(=O)N2 C#CCN(C)C(=O)[C@@H1]1C[C@@H1]1C(=O)N[C@H1](CC=C)CNC(=O)C2=CN=C(S)N=C2 CC1=CC=CC(C(F)(F)C(=O)NC[C@@H1]2C[C@H1]3CN(C(=O)C4=CC=CS4)C[C@@H1]23)=C1 CCC1=CC=CC(CC(=O)N(C)[C@@H1]2CC[C@H1]3CN(C(=O)C4=CN(CC)C=N4)C[C@@H1]32)=C1 CC(C)C=1OC=CC=1C(=O)NCC2CN(C(=O)C3CCN(C4COC4)CC3)C2 C[C@@H1]1C[C@H1](C(=O)NCCCN2CCCCC2)CCN1C(=O)C3=NN(C)C(=O)CC3 C=C(C)CCCC(=O)NC1(CCOC)CCN(C(=O)[C@@H1]2CCC3(CCC3)O2)CC1 COC[C@@H1]1CN(C(=O)CN2C=NC([N+1](=O)[O-1])=N2)CCN1C(=O)C[C@H1]3CCCCO3 O=C1CC[C@@H1](C(=O)N2CC(NC(=O)C3(C4=CC=CS4)CCCC3)C2)O1 CCOC1CC(CC(=O)N(CC(=O)NOCCOC)C2CC2)C1 C=C(CCNC(=O)C(OC1=CC=C(Cl)C=C1)C)CNC(=O)C=CC2=CN=CN2C COCC[C@H1](C)C(=O)NC[C@@H1](CNC(=O)C1(N2C=NC=N2)CC1)C(F)(F)F COCCNC(=O)[C@H1](C1CCC2(CCCC2)CC1)N(C)[C@@H1]3CC4=CC=CC=C43 CC(C)C[C@@H1](C)C[C@@H1](C)C(=O)N[C@@H1]1C[C@H1]2[C@@H1](C1)[C@@H1]2NC(=O)C3CC(=O)NC(=O)C3 COC(=O)[C@@](C)(F)C(=O)N(C)CC1=CC=CC(CNC(=O)C(C)(C)CF)=C1 CCOC[C@@H1](C)C(=O)N1CC[C@H1](CC)C[C@@H1]1C(=O)N(C)C[C@@H1](C)N(C)C(C)=O CC#CC[C@H1](NC(=O)C=1[NH1]C=CC=1COC)C(=O)NCC=2N=COC=2COC CC1=CC=CC(C(=O)N2CC=C[C@@H1]2CNC(=O)[C@](C)(O)CC3=CC=CC=C3)=C1F CC1=CSC=2C(=N[C@H1](C)CNC(=O)[C@H1](C)N3C(=O)CCC3=O)[NH1]C(C4CC4)=NC1=2 CCC1(C(=O)N[C@@H1](C)CN2CCN(C(=O)CCOCCOC)CC2)CCOCC1 N=C1N=C2C(=C[NH1]1)CN([C@@H1](C(=O)NCCCC3CC3)C=4C=NN(C5CC5)C=4)C2 CC[C@@H1](CN(C)C(=O)C1=CN=C(OC)N=C1)NC(=O)C2=CC=CC=3N=C(O)[NH1]C2=3 CC1=CC(C#N)=CC=C1S(=O)(=O)N2CCN([C@@H1](C)C3=CSN=N3)CC2 CO[C@@](C)(C(=O)N[C@H1]1C[C@@H1](N=C2C=C(C(C)C)N=C(Cl)[NH1]2)C1)C3=CC=CC=C3 C[C@H1](NC(=O)[C@@]1(C)C[C@H1](O)CN1C)C2=CC=CC(Br)=N2 O=C(CCC[C@@H1]1CCCO1)N[C@H1]2COCC[C@H1]2C(=O)NC3(C4CC4)CC3 COC(=O)[C@@H1]1CCCN1[C@H1](C(=O)N[C@@H1](C)C(=O)OC)[C@@H1](CC(C)C)OC C#CC1=CC=C(C(=O)NC[C@H1](O)CCNC(=O)C2=C[NH1]N=C2[N+1](=O)[O-1])C(C)=C1 CN1C(=O)[C@@H1](C(=O)C2=CC=C(N3CCCC3)N=C2)CC4=CC=CC=C41 CCN(CC1CCN(C(=O)CC(C)(C)C(F)(F)F)CC1)C(=O)COCC(C)(C)C COCCN(C)C(=O)[C@@H1]1C[C@@]12CCN(C(=O)C3(CC(=O)OC)CC3)C2 CC(C)[C@@H1](CNC(=O)C1=CC=C(C(C)(F)F)N=C1)NC(=O)[C@@H1]2C[C@@H1]3CCCC[C@@H1]32 CC(C)(C(=O)N[C@@H1]1CC[C@H1](CNC(=O)C2=CSN=N2)C1)C3=CC=CN=C3 CC[C@@H1](CNC(=O)C1CCC2(CC1)CC2)NC(=O)C3=NC=NC4=C3CCCC4 CCC[C@H1](CC(=O)NCC1(CCO)CC1)NC(=O)[C@H1](C)OCC(C)C CNC(=O)CCC(=O)NCC1(C(N)=O)CN(C(=O)C2=N[NH1]C=C2C)C1 C[C@H1]1C[C@H1](CO)CN(C(=O)CNC(=O)CNC(=O)CC2=CC=CN=C2F)C1 COCC1(NC(=O)[C@H1]2C[C@@H1]3CCC[C@@H1]3C2)CCN(C(=O)COC(=O)CO)CC1 O=C(CC1(O)CCC1)N[C@@H1]2CCC[C@H1]3CN(C(=O)C4=CC=CN=N4)C[C@H1]32 COC1=CC=CC(C(=O)NC[C@@H1]2C[C@H1](C)N(C(=O)/C=C/CCC(C)C)C2)=C1OC COCC(=O)N1CC(CNC(=O)[C@@](C)(F)C(C)(C)F)(C(N)=O)C1 C[C@H1]1CCN(C(=O)C2=CC=CO2)C[C@@H1]1CNC(=O)CCN3C=CC(=N)[NH1]3 COC1=CSC=C1C(=O)N(C)[C@@H1]2CN(C(=O)CC3CCCCC3)CC[C@@H1]2O C[C@H1]1CN(CCN=C2C([N+1](=O)[O-1])=C[NH1]C3=CC=C(Cl)C=C23)C[C@@H1](C)O1 C[C@H1](N=C[NH1]C1=CC(Cl)=C(S(=O)(=O)N[C@@]2(C)CCC[C@@H1]2C)C=C1S)C3=NN=CS3 CC1=CC=C([C@@H1](CNC(=O)[C@H1]2CC[C@H1](O)C2)NC(=O)C3(C4CC4)CC(=O)C3)C=C1 COCCC(=O)N(C)[C@H1](C)CNC(=O)[C@@H1](NC(=O)C1=CC=CO1)C(C)C C=C(C)CNC(=NCCOC(F)F)NCC1=NOC(C=2C=CSC=2)=N1 C#CC[C@H1](CC(=O)N[C@]12CCC[C@H1]1C2)NC(=O)C(C)(C)CO CC1=C(Br)C=NC=C1C(=O)N2CCOC[C@H1]2CNC(=O)C3=CC=C(Br)C(Br)=C3 O=C(C1=CC(Cl)=CC=C1N2C=CN=N2)N3CCC([C@@H1]4COC(=O)N4)CC3 C[C@H1](C#N)C(=O)N1CC[C@@H1]1C(=O)N2CC[C@]3(COC(=O)N3)C2 CC[C@H1](C(=O)N1CC(NC(=O)C2=CC=C(C3CC3)C(Br)=C2)C1)C4=CC=CC=C4 COCC(F)(F)C(=O)N1[C@H1]2CC[C@@H1]1C[C@H1](NC(=O)/C=C/C3=CN=C[NH1]3)C2 CC(C)(CS(C)(=O)=O)C(=O)N[C@H1]1C[C@H1]2C[C@@H1](NC(=O)C(C)(C)C(N)=O)[C@H1]2C1 CC(C)N1C[C@@H1](NC(=NCC2=CC=C3OC=NC3=C2)NC4CCC4)CC1=O CCC=1OC(C(=O)N2CCOCC[C@H1]2C(=O)N(CCO)CC3CC3)=CC=1C N=C1[NH1]C=C(C(=O)N2CC(C[C@H1](F)C(=O)NC3CCCC3)C2)S1 CC1=NC2=CC=C(C(=O)N(C)CCN(C)C(=O)[C@]34OCCC[C@@H1]3C4(F)F)C=C2S1 C[C@@H1](OC1=CC=C(O)C=C1)C(=O)N[C@](C)(CO)CNC(=O)C2=CC(F)=C[NH1]2 CCCC=1N=COC=1C(=O)N[C@@H1]2C[C@H1]3CC[C@@H1]2[C@@H1](NC(=O)C=4[NH1]C=NC=4C#N)C3 CC(C)(CNC(=O)[C@@]1(C)COCCO1)CC(=O)N2C[C@H1]3CC[C@H1](O)[C@H1](O)[C@H1]32 NC1=CC(CN2CCC(C3=N[NH1]C4=C3CNCC4)CC2)=CC=C1Br CCN1N=CC(C)=C1C(=O)N[C@H1](C)C(=O)NC[C@@H1](C)CC(F)(F)F C[C@H1](C(=O)OC(C)(C)C)S(=O)(=O)NCC1=CC=CC(N2CC=CC2)=C1 CC1=CC=C(SCC(=O)NC[C@@H1](CO)NC(=O)CC2=CN=CN2C)C=C1 CC=NC=CCNC(=O)[C@@H1]1CCC[C@@H1]1NC(=O)C2=N[NH1]C3=C(F)C=CC=C23 CCCOCC(=O)N[C@](C)(C(=O)N1[C@H1]2CC[C@H1]1COC2)C3CCC3 CC1=CC(C(C)(C)C(=O)N2CC(CCNC(=O)C[C@@H1](C)N(C)C)C2)=CS1 C[C@H1](CN(C)C(=O)C1=CC(Cl)=CC=C1F)N(C)C(=O)C#CC2CCC2 CNC(=O)CCCC(=O)N[C@H1](CCNC(=O)CC1=CC=C(C(C)=O)S1)C(C)C CC1=CC(C)=CC(C(=O)N[C@](C2)CCN(C3=NC(C(C)C)=NC=4[NH1]C=CC3=4)C2)=C1 CC1(C)C[C@@H1](NC(=O)C2=CC(Cl)=CC=C2F)CN(C(=O)C3(F)CC3)C1 CCC(CC)[C@H1](C)C(=O)NC1(C(C)C)CCN(C(=O)C2CCC(C#N)CC2)CC1 CC1=CC(C(=O)N[C@@H1](C)C2CC(NC(=O)C3=CC=CC(O)=C3F)C2)=NN=C1C CC[C@@H1](C)CCCCC(=O)N1CC[C@@H1]1C2=CC=CC(C(F)(F)F)=C2 CO[C@H1]1C[C@@H1](CC(=O)NC2(CCNC(=O)C=3SC=NC=3Cl)CCOCC2)C1(C)C C[C@@H1](CC(=O)N1C[C@@H1](C)C(F)(F)C1)C(C)(C)NC(=O)C2=CCCOC2 CCC[C@H1](CCCNC(=O)CC[C@H1]1CCCO1)NC(=O)COCCSC CC1=C(C#N)C=CC=C1NC(=O)/C=C/CN(C)C(=O)[C@H1]2CCC(=O)O2 COC(=O)C12CC(NC(=O)CN[C@H1](C)C3=CC=C4C=CN(C)C4=C3)(C1)C2 CC(=O)N[C@@H1](CC(=O)NC[C@H1](O)CNC(=O)C1CC(N2CC(O)C2)C1)C(N)=O CC1=CC=CC=C1N2N=NN=C2[C@H1](NC3CC4(CNC(=O)C4)C3)C5=CCCCC5 CC[C@@H1]1C[C@H1]1C(=O)NCC[C@@]2(C)CCN(C(=O)C3=CC=C(COC)C=C3)C2 CCOC(=O)C1(C(=O)N(C)CCCN(C)C(=O)CO[C@H1]2CCCC[C@H1]2C)CCC1 CC1O[C@@H1]2CCN(C(=O)N(CC)CCCCO)CC[C@H1]2C1 CCCCCCCC(=O)N[C@H1]1CCSC12CN(C(=O)[C@@H1]3COC(=O)N3C)C2 CCC(CC)[C@@H1]1CCN(C(=O)[C@]2(NC(=O)C[C@@H1]3CCC[C@H1]4C[C@@H1]34)CCSC2)C1 O=C(C=CC1CCCCC1)NC2[C@H1]3CC[C@H1]2CN(C(=O)C4=CC=C([N+1](=O)[O-1])S4)C3 CC1=CC(CN2N=NC(C(=O)NC3=CC=C(S(N)(=O)=O)C=C3F)=C2C)=NO1 CO[C@@](C)(CO)C(=O)NC[C@H1]1[C@@H1]2CN(C(=O)C3CC4(CCC4=O)C3)C[C@H1]12 NC1=C(F)C=CC=C1C(=O)N2CCC3=CC=CC=C3[C@@H1]2CNC(=O)CSC(F)F C=CCCCCC(=O)N[C@H1]1CCN(C(=O)C2=CC(C)=C(OC(F)F)C(C)=C2)[C@@H1]1C CC[C@@H1]1CN(C(=O)CCCCC(N)=O)CC[C@H1]1NC(=O)C2=CN=C3SC(C)=CN23 COC1=C[NH1]C(C(=O)N(C)C2CC(NC(=O)C3=CC=NC=4[NH1]N=CC3=4)C2)=CC1=O CC#CC[C@H1](NC(=O)[C@@H1](CC)NC(N)=O)C(=O)NC1=CC=C(F)N=C1C COC(=O)C=1C=COC=1C(=O)NC[C@@H1]2CCN2C(=O)C=3C=C4N(N=3)CCNC4=O CC=1SC(Cl)=NC=1C(=O)N2CCC(N3CCN(C(=O)C4CSC4)CC3)CC2 C[C@H1](CC(=O)N1CCN(C(=O)[C@@H1](O)CN2CCCC2)C[C@H1]1C)CN(C)C CSC=CC(=O)NCC[C@H1]1C[C@H1](NC(=O)C2=CC=C(Br)C=N2)C1 CC/C=C/CC(=O)N(CCOC)C1CCN(C(=O)CCCC2=CSC(C)=N2)CC1 CC(C)N1C=C([C@@H1](C(=O)NCCC2(C)CC2)N3CC[C@@H1](CN(C)C)C3(C)C)N=N1 C=CCC[C@@H1](CO)NC(=O)C1=C[NH1]N=C1[C@@H1]2CCCCN2C(=O)C3=NO[C@H1](C)[C@H1]3C CC[C@H1](C)/C=C/C(=O)N1CC(NC(=O)[C@H1]2CCOC2)C1 CN1C[C@@H1](C(=O)NCCCN(CC2=CC=C(C(=O)O)C=C2)C3CC3)CCC1=O C[C@@H1]1[C@H1](C(=O)NC2=CC=CC(NC(=O)CCSC(F)(F)F)=C2)[C@H1]1C3=CC=CC=C3 CC[C@]1(C)CCN1C(=O)[C@@H1]2CC[C@@H1](C3CC3)N2C(=O)CCCN(C)C C[C@H1](CCC(=O)N1CC2(CCC(=O)N2)C1)NC(=O)[C@H1](O)C=3C=CSC=3 CN1N=C(C(=O)N2CC[C@H1]3CCN(C(=O)CCC4=CSC=N4)[C@H1]3C2)C5=C1CCC5 C#C[C@H1](CC1=CC=CC=C1)NC(=N[C@@H1](C)COC)NC2C3(CC3)C24CC4 CC(C)=C=CC(=O)N1CC=C[C@H1](C(=O)NCCC=2C(C)=NOC=2C)C1 C=CCC[C@H1](C(=O)NCC1=CC=CS1)N(C)C2CCN(C[C@@H1]3CCOC3)CC2 CNC(=O)CCN(C)C(=O)[C@H1]1C[C@@H1](NC(=O)C2=CN=CC=C2C#N)C13CCC3 CCC[C@H1](NC(=O)C(C)(C)Cl)C(=O)NCC[C@@H1](OC)C(C)C CCC1=CSC(CC(=O)NC[C@H1]2CCN(C(=O)CC(C)(C)O)C[C@H1]2C)=N1 CC[C@H1](NC(=O)N[C@H1](C)C1=NC(C2=CC=CN=C2)=NO1)C(C)(C)C COC(=O)C[C@@H1]1CCCCN1[C@H1](C(=O)NC2CCC2)C3=CN=NN3C C[C@H1]1CC[C@@H1]1C(=O)NC2(C3=CC=CC=C3)CN(C(=O)C4=NOC=C4C5CC5)C2 CC1=CC=CC(CCNC(=O)[C@@H1](CN2C=CN=N2)NC(=O)COC3(C)CCCC3)=C1 C[C@H1](C(=O)NCC[C@@H1](O)CNC(=O)C1=CC(Cl)=CN1C)C2=CC(Cl)=CC=C2OC CCC(=O)NCC(=O)N1CCCC[C@@H1]1CN(C)CC2=CC=NN2C C[C@]1(CNC(=O)C2=CC=C(Cl)O2)CCCN(C(=O)[C@@H1]3CCOC(=O)CC3)C1 COC(=O)C1=NC=C(C(=O)N2CCC[C@@](C)(NC(=O)C34CC5C[C@H1]3[C@H1]4C5)C2)S1 CC(C)(C(=O)N[C@H1]1C2=CC=CC=C2C[C@@H1]1NC(=O)CN3C=NN=N3)C4=NC=CO4 CN1N=C(C(=O)N2C[C@@H1]3[C@@H1](CC[C@@]3(C)CNC(=O)CCCF)C2)C4=C1CCSC4 C[C@@H1](C(=O)N(C)CC1CCN(C(=O)C2=CC=CC(C=3C=COC=3)=C2)CC1)N(C)C CSC[C@H1](C)C(=O)N1C[C@H1](O)C[C@H1]1C(=O)NCC2(CO)CCCCC2 CC1=CC=C(C#N)C=C1C(=O)NCC[C@H1](O)C(=O)NCC2(C)CCC2 CC1=CC=CC(C(=O)NCC(=O)N2CC[C@H1]3CC[C@]32CNC(=O)C(C)(F)F)=C1 CC(C)N1CCC[C@@H1]1CC(=O)N2CC3(C2)CN(C(=O)CC4=CC(C5CC5)=NO4)C3 CC(C)(C)/C=C/CC(=O)N[C@H1]1CC[C@H1](NC(=O)C2=C(F)C=CC=C2[N+1](=O)[O-1])CC1 C[C@@H1](CCC(=O)NCC1CC(F)C1)NC(=O)[C@@H1](C)C2CCC2 CN(C(=O)C1=CSC=C1S(C)(=O)=O)C2CCN(C(=O)CCN3C=CC=C3)CC2 COC1=CC=CN=C1C(=O)N(C)C[C@H1](C)NC(=O)C2=CC=C(Cl)C=C2Cl C#CCCCCCC(=O)N[C@]12CO[C@H1](C1)[C@H1](NC(=O)[C@H1](CC)C/C=C/C)C2 COC1(C(=O)N[C@H1](C)CC(=O)NC[C@@H1]2CCCCN2C)CC(C)C1 O=C(N[C@H1](CC(=O)NCCC1CCCC1)C(F)(F)F)[C@H1]2CCCOC2 C[C@@H1](NC(=O)C12CC(C(C)(C)C)(C1)C2)[C@@H1]3CCN(C4=NC=NC=C4Cl)C3 CC[C@@H1]1CN(C(=O)C2(O)CCC2)CC[C@H1]1NC(=O)C3=CSC(Br)=C3 O=C([C@H1]1CC=CCC1)N2C[C@H1](O)C[C@H1]2CNC(=O)C3(C(F)F)CCOCC3 C=C[C@](C)(O)CC(=O)N[C@H1]1CCCC12CCN(C(=O)C3=CSC(C(N)=O)=N3)CC2 C#C[C@]1(NC(=O)C2(NC(=O)CNC(=O)OCC=C)CCC2)C[C@H1]3CCC[C@H1]31 CO[C@H1]1C[C@@H1](CNC(=O)[C@H1]2C[C@@H1]2C(C)(F)F)N(C(=O)CN3C=C([N+1](=O)[O-1])C=N3)C1 CC[C@@H1](CNC(=O)C1=CSC([N+1](=O)[O-1])=C1)NC(=O)C2=CC=C(F)C(Cl)=C2 CC1=NC(C)=C(C(=O)N[C@H1]2COCCN(C(=O)C3=CC=CC=C3[N+1](=O)[O-1])C2)O1 CCCCCCCC(=O)N(C)[C@@H1]1CCCN(C(=O)C2=CN=C3N=CC=CN23)CC1 CC(C)OC1=NC(N(C(=O)C=2C=CON=2)[C@@H1]3CCN(CC4=CSC=N4)C3)=NC=C1Br C[C@@H1](NS(C)(=O)=O)C(=O)NCCNC(=O)C1CN(C(=O)C2=COCC2)C1 CCN(C[C@H1]1CCCO1)C(=O)C(=O)NCC2=NC(Br)=N[NH1]2 CC1=NC(C)=C(C(=O)N2C[C@@H1](CO)C3(CN(C(=O)C[C@@H1]4C[C@H1]5CC[C@H1]4O5)C3)C2)S1 CC(C)[C@@](F)(CNC(=O)C[C@H1]1CCCSC1)C(=O)N[C@H1]2CCOC2 COC(=O)C=1N=C(NC(C)(C)CNC(=O)[C@H1](CC(C)C)NC(C)=O)SC=1C C[C@H1](CCNC(=O)C[C@@H1]1C[C@H1](C)O[C@H1]1C)NC(=O)C=2C=CN(O)C(=O)C=2 CC(C)[C@@H1](NC(N)=O)C(=O)NCC1(F)CC(NC(=O)CCC2=CN=C(O)[NH1]2)C1 CC[C@H1](CC(=O)N(CC)[C@H1]1CCN(C(=O)C2=CC=C(OCC(F)F)N=C2)C1)OC C[C@H1](C(=O)N1C[C@H1]2[C@H1](NC(=O)C3=CC4=C(C=N3)OCCO4)[C@H1]2C1)N5C=CC=N5 CCCCCN(C)CCC(=O)N1CC2(CC(NC(=O)C[C@H1](C)C3CCCCC3)C2)C1 C=CCCCC(=O)NC[C@H1]1C[C@@](F)(CNC(=O)C2=CC=C(OCCC)C=C2)C1 CCC(CC)CC(=O)NCC[C@@](C)(CC)NC(=O)[C@@H1]1CCCN1N=O CCC(OC)C(=O)N1CCC(CN(CC)C(=O)C2=CC=C3NC(O)=NC3=C2)CC1 [N-1]=[N+1]=NC[C@@H1]1CCN1C(=O)CCN(CCO)C(=O)[C@H1]2COC[C@H1]2C(N)=O CO[C@]12CC[C@H1]1CN([C@H1](C(=O)NCCCF)C3=CC=C(CCF)C=C3)C2 C#CCN(CCC(=O)NCC1=CSC(C)=C1C)C(=O)C2=NC(C)=CC=C2F O=C(COC[C@@H1]1CCCCO1)NC2CCCN(C(=O)[C@H1]3C[C@@H1]4C=C[C@H1]3C45CC5)C2 C=CC(C)(C)CC(=O)NC[C@@]12C[C@@H1](CCO1)N(C(=O)[C@@H1]3CCN4N=NC=C4C3)C2 COC1=CC=C(CC(=O)N2CC[C@H1](C)[C@@H1]2CNC(=O)CN3C=NN=C3)C=C1F CN(CC(F)(F)F)C(=O)[C@@H1]1C[C@H1]1NCC2=CC=C(C(=O)NC=3C=N[NH1]C=3)C=C2 CC(=O)N1CC[C@]2(C1)CN(C(=O)C[C@@H1]3COC4CC3C4)C[C@H1](C)O2 C[C@H1](O)C(=O)NC1CCCN(C(=O)/C=C/C2=CC=CC(C(F)(F)F)=C2)CCC1 CCOC(CC(=O)NC(C1NC(=O)C2=C(C)N=NN2C)CCCCCC1)OCC CCCC(=O)N1CSC[C@@H1]1C(=O)N[C@@H1](CC)CNC(=O)C=2[NH1]N=NC=2C CC[C@]1(C)CCN(C(=O)CCN(C)C(=O)C2=COCCC2)C1 COC1=CC=C(CC(=O)N[C@]2(C)C[C@@H1](NC(=O)C3CC(C)(C)C3)C2)C=C1F C[C@@H1]1CN(C(=O)[C@H1](F)CC2CCC2)CCCN1C(=O)C3=CC=C4N=C[NH1]C4=N3 CO[C@H1](CC(C)C)C(=O)NCC[C@H1]1C[C@H1](NC(=O)C2=NOC=C2C(C)C)C1 CCC1=NN=C(CN(C)C(=O)[C@@H1](C)CC(=O)C2=CC=CC(F)=C2)O1 COC1=CC2=CC=C(N[C@@H1]3CC(=O)N(C4=CC=CN=C4)C3)C=C2C=C1OC C[C@H1]1C[C@@H1]1CCCNC(=O)CC2CCC(NC(=O)C3=NC=CC=4C=C[NH1]C3=4)CC2 C[C@H1]1[C@@H1](NC(=O)[C@H1]2CN3CCN2C[C@H1]3C)CCN1C(=O)CC(C)(C)C(F)F CC1(C)C[C@]2(CCO1)CCN(C(=O)[C@H1](O)C[C@H1]3CC3(F)F)C2 CN1C=C(C(=O)NC2(CNC(=O)C(C)(C)[C@@H1]3CCOC3)CCCC2)C(O)=NC1=O NC(=O)[C@H1](CO)NC(=O)C[C@@H1]1[C@@H1](NC(=O)C2=CC=C(F)C(F)=C2)C[C@H1]1O O=C(NCC12CCC(CC1)N2C(=O)C3=C[NH1]N=C3C4CC4)[C@@H1]5CCC6=C[NH1]N=C65 C=C1CC2(C1)CC(C(=O)N3CCC[C@H1](NC(=O)C[C@H1](C)C(F)F)C3)C2 O=C(C1=C[NH1]N=C1I)N2CCOC3=C(C=4N=N[NH1]N=4)C=CC=C3C2 NC1=CC(F)=C(Cl)C=C1C(=O)N[C@]23CCC[C@@H1]2CN(C(=O)C4=CN=CO4)C3 CCC[C@@H1](F)C(=O)N[C@@H1](C)[C@@H1](CO)NC(=O)CC1CN(C)C1 C[C@@H1]1C(=O)N(CC(=O)N2CCN(C(=O)CSCCC(F)(F)F)[C@H1](C)C2)C(=O)[C@@H1]1C CC(C)=CC(=O)NC[C@@](C)(O)CNC(=O)CCC1=CC=C2C(=C1)CCO2 CO[C@H1]1CCCN(C(=O)[C@@H1]2CC3(CC3)CN2C(=O)C4=NOC=C4C(C)C)C1 C=C(Cl)C[C@H1](NC(=O)OC(C)(C)C)C(=O)N1CCC[C@@H1]1CN(C)C(=O)CCCC COC1(CNC(=O)C=2C=C(OC(F)(F)F)OC=2C)CCCCCC1 C[C@@H1]1CCN(C(=O)CSC(=N)N)CCN1C(=O)[C@H1]2C3=CC=CC=C3C4CC2C4 C[C@H1]1CCN2C(C(=O)N[C@H1]3CCN(C(=O)CCC4CCN(C)CC4)C3)=CN=C2C1 FC=CC(CN1CCOC[C@H1](CNC(=O)C2(C3=CC=C(F)C=C3)CC2)C1)=C(F)F CO[C@H1]1CCCN([C@H1](C(=O)NC(C)C)C2=CC3=CC(F)=CC=C3O2)CC1 CCS[C@H1](C)C(=O)N1CCC2(CC1)CN(C(=O)[C@H1](O)C3=CN=C[NH1]3)C[C@@H1]2CO CC[C@H1](CN(C)C(=O)C[C@@H1](C)OC)NC(=O)C1=CC=C(C(=O)N(C)C)N=C1 CCC=1N=C[NH1]C=1C(=O)NC2(C)CCC(NC(=O)[C@@H1]3C[C@]3(C)C(C)C)CC2 CNC(=O)NCC(=O)N1CCN(C(=O)[C@@H1](O)C(C)(C)C)C[C@@H1]1CS(C)(=O)=O CCC[C@H1](CC1=NC=CN1C)NC2=CC=C(S(=O)(=O)CC)C=C2Cl CCOC(=O)[C@@H1](C)N(C)C(=O)[C@H1](NC(=O)C1=CC(C)=CC(O)=C1)C(C)C COC1=CC=C(CC[C@@H1](C)NC(=O)N2CC(C)(C)C3=NC=CC=C32)C=C1 CCCCS(=O)(=O)CC(=O)N(C)C[C@H1](C)CNC(=O)C1=CC(C)=C(CC)S1 CC1=NO[C@H1](C(=O)N2C[C@H1]3CCC[C@@]3(CNC(=O)C=4SC=C(C)C=4Cl)C2)C1 CC/C=C/C[C@@H1](C)C(=O)N1CCN(C(=O)[C@@H1](O)C2=CC=C(OC)C=C2)C3(CC3)C1 CCC[C@@H1](NC(=O)C1=CC=C(F)C(F)=C1)[C@H1](O)C(=O)N2CC[C@@H1](C)C[C@H1]2C CCN(C[C@@H1](C)NC(=O)C[C@H1](C)CCC=C(C)C)C(=O)CCC(=O)NN(C)C CC1=CC=C(C(C)(C)C(=O)N[C@H1](C)CCNC(=O)C2=NC=NC(C)=C2C)C=C1 CC1(C(=O)N2CC3(CCOC[C@@H1]3C(=O)NC4=CC=CN=C4C)C2)CCC1 COCCCC(C)(C)NC(=O)/C=C/CNC(=O)[C@@]1(Cl)C[C@H1]1C(C)=O C[C@H1](SC[C@@H1]1CCCO1)C(=O)N[C@H1]2C[C@@](F)(CNC(=O)CCCC#N)C2 CC(C)C[C@@H1](C)C(=O)N1CCN2N=CC([S@](C)(=O)=NC(=O)C3=CSC=N3)=C2C1 COC1=CC=C(F)C(C(=O)N2CC[C@@H1]3CC[C@@H1](NC(=O)[C@@H1]4C[C@H1]4CF)[C@@H1]32)=C1 CCC1=CC=C(C(=O)N2CC[C@](C)(CNC(=O)C[C@H1]3CC[C@@H1](O)C3)C2)C=N1 C#CC1=CN=C(C(=O)NC[C@]2(C(C)(C)C)CCN(C(=O)[C@H1](O)C#C)C2)C(C)=C1 C=C=CCCC(=O)N[C@@H1](C)CCN(C)C(=O)C1=CC(C2CC2)=CC=N1 C#CC1=CC(F)=CC(C(=O)N(C)C[C@H1]2CCCCN2C(=O)[C@H1](O)C3CC3)=C1 CC(C)N(C)CC1=CC=C(C(=O)NC[C@@H1]2CC[C@@H1](N)C2)C=C1 CN=C1[NH1]C(C(=O)N2C[C@@H1]3C(CNC(=O)C4=CC(C(C)(C)C)=C[NH1]4)[C@H1]3CC2)=CS1 CCC1=CC=C(C(=O)NC[C@H1]2C[C@@](F)(CNC(=O)[C@@]34CC[C@@H1](OC)[C@@H1]3C4)C2)N=C1 CC=1C=NSC=1[C@@H1](C(=O)NCCC2(C)CC2)N3CCN4C(CC(C)C)=NN=C4C3 CCCC(=O)NC[C@@H1](CNC(=O)C1=CC(C2=CC=CC=N2)=NS1)OC COCCN(CCNC(=O)C1=CC(C)=CC(Cl)=C1)C(=O)CC(C)(F)F CCC(CC)OCC(=O)NC1(CC(=O)N2CC3(CCOC(=O)N3)C2)CC1 CO[C@H1](C(=O)N1CC[C@H1]2[C@@H1](C1)NC(=O)CN2C(=O)C=3C=C[NH1]C=3C)C4CC4 O=C(NC(=O)N1CCC[C@]2(CC[C@@H1]2O)C1)C3=CC=C(F)C(F)=C3 C[C@@H1]1C[C@@H1](N=C2[NH1]N=C(C(N)=O)S2)CN1C(=O)C3=CC=C(N(C)C)C=C3 O=C(CN1C=C(Br)C=N1)N2CCC3(CC2)CCN(C(=O)[C@@H1]4CC5CCC4CC5)C3 CCC1=CN=CC=C1C(=O)N2C[C@H1](NC(=O)C[C@H1]3CCC(=O)NC3)C(C)(C)C2 C[C@@H1](C(=O)N1CCOC2(CCN(CC3=CC(I)=CC=C3Cl)CC2)C1)C4CCC4 CC1=CC=C(CN2CCCN(C(=O)C3=NC=CC=N3)CC2)C=N1 CC1=NOC(=O)[C@H1]1CC(=O)N[C@@H1]2C[C@H1](O)[C@@H1](NC(=O)C3=CC=4OC=CC=4[NH1]3)C2 COC[C@@]1(C(=O)N[C@@H1]2CN(C(=O)CCC(C)(C)C)C[C@H1]2O)CC1(F)F CCN1N=CC(CN(C)C(=O)N=C2[NH1]N(CC(F)(F)F)C=C2C#N)=C1C COC(=O)C(=CC1=CC=CC(C2=NC(N)=CN2C)=C1)C3C[C@@H1]4CC[C@H1](C3)NC4=O O=C(C1CCCCCC1(F)F)N[C@H1]2CC[C@H1]2CNC(=O)C3=CC(C4CC4)=CC=N3 CSCCC(=O)N(CC1(O)CNC1)C2=NC(C)=NC=3[NH1]C(C)=NC2=3 O=C(C=CC1CCC1)NC[C@@H1]2CO[C@@H1](CNC(=O)CN3C=NC(C(F)(F)F)=C3)C2 CC=1N=NN(CC(=O)NC2C[C@@H1]3C[C@@H1](CNC(=O)C=CCO)CC[C@H1]3C2)N=1 C[C@@H1]1C[C@@H1](C)CN(CCCNC(=O)NC2=NC(Cl)=NC=C2Br)C1 O=C(NC[C@@H1]1CCCO1)[C@]2(F)CCN(CC3=CC(Cl)=CC=C3[N+1](=O)[O-1])C2 O=C(CCCOC1=CC=C(Cl)C(Cl)=C1)NC2CC(NC(=O)C3=CN=CO3)C2 CC1=NN(C)C=C1CC(=O)NC[C@H1]2CCC23CCN(C(=O)C(C)(C)O)CC3 C=C(Br)CC(C)(C)C(=O)NC[C@H1]1C[C@H1]1NC(=O)CCSCC2=CC=CC=N2 CC1=NC(F)=CC=C1NC(=O)C[C@@]23CC[C@H1]2CN(C(=O)CN4CCOCC4)C3 CN1N=CC(C(N)=O)=C1C(=O)N2CC[C@H1](NC(=O)C#CC3CC3)C2 CCCN(C)CCC(=O)N[C@H1]1C[C@@H1]2C[C@H1]1C[C@@H1]2C(=O)NC3=C[NH1]C=CC3=O CC1=CC(OCC(=O)N[C@H1](CC2CCC2)C(=O)NCCCC3=NN=NN3C)=NO1 CO[C@@H1](CC(C)C)C(=O)N(CCCO)CCC(=O)N[C@H1](C)C(=O)NCC(C)C CN1CC[C@@H1](C(=O)NC[C@@H1](F)CNC(=O)C2=CC=CC(N)=N2)C1 C[C@@H1](O)[C@H1](C(=O)NC[C@H1]1CC[C@H1](N(C)C(=O)C#CC2(C)COC2)CC1)N(C)C O=C(NC[C@@H1]1C[C@H1]2CC[C@@H1]1N2C(=O)CC3=CCOCC3)[C@@H1]4C[C@]4(F)Cl NC(=O)C[C@H1](NC(=O)C[C@H1]1CSCCO1)C(=O)N[C@@H1](C(N)=O)C2CC2 CC1=CC=C2C(=C1)CCN(C3=NC(=NC[C@@]4(C)CC4(Cl)Cl)[NH1]C5=C3CCC5)C2 CN(CC(=O)NCC#CCNC(=O)[C@@H1]1CCC2=CC=CC=C21)C3=CC=C(Cl)C=C3 CCC1=NC=CC=C1C(=O)N(C)C[C@@H1](C)CNC(=O)[C@@]23C[C@H1]2COC3(C)C N[C@H1]1C[C@@H1](CCC(=O)NCCN2CCC3=CC=CC=C32)C1 CO[C@H1](C=1N=C(C2=CC=CC(N3C=CN=C3)=C2)N(CCCCO)N=1)C4CC4 C=CCCCCC(=O)N1CCC2(C1)CN(C(=O)[C@H1]3C[C@@](C)(O)C3)C2 CC(=CC(=O)N1CCC(CCN(C)C(=O)C[C@H1](O)CN(C)C)CC1)C(F)F CCN1C=C(CC(=O)N2C[C@@H1](CNC(=O)C=CC3CCCC3)C4(CCC4)C2)C=N1 CC1=CC=NC(NC(=O)[C@H1]2C[C@H1](NC(=O)[C@H1](C)OC3=CC=CC=C3)C2)=C1Br CC[C@@H1](N[C@@H1](C)C1(O)CCOCC1)C2=CC=CC(Br)=C2 CC1=CN=C(CC(=O)N2[C@@H1](C)CN(C(=O)[C@@H1]3CC=C[C@H1](O)C3)C[C@H1]2C)S1 CC=1C=CSC=1CC(=O)NCC23CC(NC(=O)C4(C)CCCCC4)(CO2)C3 O=C(CCCC=1N=C[NH1]N=1)NC2CC(NC(=O)CSC3=NC=NC=4[NH1]C=NC3=4)C2 COC(=O)[C@@H1]1CC=CC[C@H1]1C(=O)N2CCC(NC(=O)C3=NC(C)=CN3C)CC2 C[C@H1](NC(=O)C=1OC=NC=1C2CC2)[C@H1]3CN(C(=O)[C@H1]4CC4(F)F)CCO3 COC(=O)[C@@H1]1[C@@H1](C)CCN1C(=O)[C@@H1]2CCCCN(C(=O)C3=CC[C@H1](C)CC3)C2 C[C@H1]1C[C@@H1](C(=O)N[C@@H1](CO)C2CCN(C(=O)[C@H1](C)CC(C)(C)C)CC2)CC(=O)N1 CC1=CC(C(=O)N2CCCC[C@H1]2[C@H1](C)N=C3C=CN=C(CO)[NH1]3)=NN1C4CC4 C[C@H1]1CCN(C(=O)C2=CC(Cl)=CS2)C[C@H1]1CNC(=O)C3=CN=C(C(C)(C)CF)O3 CCC1=CC=C(C(=O)NC[C@H1]2CN(S(=O)(=O)C3=CC=CC(F)=C3C)CCO2)C=C1 CCC[C@H1](C)CC(=O)NC[C@@H1]1CN(C(=O)C=2C(C)=NN(C)C=2N)CC3(CCC3)O1 CP(C)(=O)[C@H1]1CCC=C1C(=O)NC[C@@]2(O)CCN(C(=O)C=3C=C[NH1]C=3)C2 COCC1=NC(C(=O)N2CCN(C(=O)CN3CCC(O)CC3)C[C@H1]2C(F)F)=CS1 C[C@@H1](CNC(=O)C[C@@H1]1CNC(=O)C1)CNC(=O)C[C@@H1]2CC2(C)C O=C(NCCC1CC1)[C@H1](C=2N=NN(C)N=2)N3CCC(=O)N4CCOC[C@@H1]43 CCC(CC)(C(=O)O)C(=O)N(C1=CC(C)=NC(C)=N1)[C@@H1]2CNCC2(F)F C=CCOCC(=O)N1CCC[C@@H1]1C(C)(C)CNC(=O)CN2C=C(C)C=CC2=O CC=1[NH1]C(C)=C(C(=O)NC2CCCN(C(=O)[C@H1](C(C)C)N3C=C(C)C=N3)C2)C=1C C#CC1=CC=C(C(=O)N[C@H1](CC=C)C(=O)NCC2=CC=NC=C2C)N=C1 CN(C(=O)COCC1CCCC1)[C@H1]2CCCN(C(=O)C3=CC(O)=NC=C3F)CC2 C[C@]1(CNC(=O)C2=CN=CC3=C[NH1]N=C23)CC[C@@H1](NC(=O)CC=4C=N[NH1]C=4)C1 COCC=C(CN1CCC2(CC1)CN(C(=O)CCC3=CSC=N3)C[C@@H1](C)O2)SN CNC(=O)[C@@H1]1CCC[C@@H1]1NC(=O)NC[C@@]2(C(=O)O)CCCS2(=O)=O C[C@H1](C(=O)N[C@H1]1CN(C(=O)C2=CC=CC=C2CN(C)C)C[C@@H1]1F)C(F)F CN(C[C@@H1]1CCN(C(=O)C=2C=COC=2C3CC3)C1)C(=O)C4=C(F)C=CC=C4Cl O=C(CC1=NC(C2CC2)=CS1)N3C[C@@H1]4C[C@H1]3CN4C(=O)[C@@H1](C5CC5)N6CCCC6 CN(CCN(C)C(=O)[C@@H1](O)C1=CC=C(Cl)C=C1)C(=O)C2=NC=CC=3C=C[NH1]C2=3 CC=NOC=NC(C(=O)N1C[C@@H1]2CC[C@]2(NC(=O)C=3SC=CC=3C(F)F)C1)=CC=C CC(C)OC1(C(=O)N2CC[C@]3(NC(=O)C4=CC=CC=N4)CCCCC[C@@H1]23)CCC1 C[C@@H1]1CCC[C@@H1](NC(=O)NCCC2=CC=NC(C(F)(F)F)=C2)[C@@H1]1C CCOC(=O)NCCCC(=O)N[C@@H1]1C[C@@H1]2C[C@H1](NC(=O)[C@@]3(C)CNC(=O)C3)[C@H1]1C2 CN1CCC[C@H1](C(=O)NC(C)(C)C/C=C/C(=O)N2CCC23CC(C(N)=O)C3)C1 CN(CCCCCNC(=O)[C@@]12CC[C@@H1](O)[C@@H1]1CC2)C(=O)[C@@H1]3CC4=CC=C(Cl)C=C43 CC1=NO[C@@H1](CNC(=O)C2(F)CN(C(=O)CCN3CCOC3=O)C2)C1 CCC1=NC=CN1[C@H1](C)CC(=O)NC[C@@H1]2CN(C(=O)C=3C=NSC=3)CCCO2 O=C(NCC[C@@]1(O)CCCN(C(=O)CCCN2C=CC=N2)C1)[C@@H1]3CSCCS3 C[C@@H1](CC1=CC=C(F)C=C1)C(=O)N[C@@H1]2CN(C(=O)CC3=NNC(=O)C3)C(C)(C)C2 O=C(N[C@@H1](CNC(=O)[C@]1(F)CC=CCC1)C2CC2)C3=CC=NC=4[NH1]C(O)=NC3=4 CC[C@@]1(C(=O)N2CCCC[C@H1](CNC(=O)C3=CC(C)=C[NH1]3)C2)CCNC1=O CC1=NC=2[NH1]C(C(=O)NCCC3CCN(C(=O)C4(CCO)CC4)CC3)=CC=2S1 COC1=CC=C(C2=CN([C@@H1](C)CNC(=O)[C@H1]3C[C@H1]4CCCCC[C@@H1]34)N=N2)C=C1Cl CCCC(=O)N1CCC(C(=O)NCCC[C@H1](C)NC(=O)CC2CC3(CCC3)C2)CC1 CC1=CC([C@@H1](O)CNC(=O)[C@@H1]2CSCN2C(=O)[C@@H1](C)OCCC(C)C)=CC=C1F C#CCCOCC(=O)N[C@@H1]1C[C@@H1]2C[C@H1](NC(=O)C=3SC=C4C=3OCCO4)C[C@@H1]21 CCC1=CC=C(NC(=O)[C@@H1](O)CCNC(=O)C[C@@H1]2CCCNC2=O)C(C)=N1 CC(C)N(CCN(C)C(=O)[C@H1](O)C1CCCCC1)C(=O)C2=CC=NN2CC3CC3 C[C@@H1](C1=CC=C(Cl)C=C1)N(C)S(=O)(=O)C2=CC=C(NC3CC(O)C3)C=C2Br O=C(C1=CC=CC=C1)N2CCN(CC3CN(CC4=CC(Br)=CC=N4)C3)CC2 CC1=NC=C(CC(=O)N2CC[C@H1](NC(=O)C3=CC4=CC=CC(Cl)=C4S3)C[C@@H1]2C)S1 COC1=CC(C2=CC=C(NS(=O)(=O)C3=CC=CC(Br)=C3F)S2)=CC=C1O CC[C@H1](CC(=O)N[C@H1]1C[C@H1](NC(=O)C2=CC(C)=CN3C=CN=C23)C1)SC CC[C@H1](C)[C@H1](C)C(=O)N1CC[C@H1](CNC(=O)C[C@@H1]2CCN3C=NC=C3C2)[C@@H1](O)C1 CC=1N=C(Br)SC=1C(=O)N[C@H1]2C[C@@H1](NCC3=CC=C(O)C=C3Br)C2 CCCCCCOCC(=O)NC[C@@H1]1C[C@@H1]1CNC(=O)C2=NC(C)=NC=C2Cl CCC[C@@H1](C)CN(C)C(=O)[C@@]1(C)CCN(C(=O)CCCCC(C)(C)C)C1 CC[C@H1](CC(=O)NC[C@]12CCC[C@@H1]1N(C(=O)C3=CC=NC(Cl)=C3)CCC2)OC C[C@H1](NC(=O)[C@@H1](F)C1CCC1)C2CN(C(=O)C3=CC=C4C(=C3)OC(C)(C)C4)C2 COC1=NC=C(C)C=C1C(=O)N(C2=NC=CC(Br)=N2)[C@H1](C)[C@@H1]3CCCNC3 CC1=CC=NC=C1CC(=O)N(C)[C@H1]2CC[C@H1](NC(=O)CCCC(F)(F)F)C2 O=C(C1=NC2=CC=C(C3=CC=C(C4=CC=CS4)C=C3)C=C2S1)N5CCOCC5 CCC(CC)C(=O)N[C@H1]1CCC[C@@H1](CN(C)C(=O)C2=COC3=CC(F)=CC=C23)C1 CCCCCC(C)(C)C(=O)N[C@@H1](CNC(=O)C=1C=CN(O)C(=O)C=1)C2CCCC2 COC1=CC=CC2=CC=C(CN3C[C@@H1](F)C[C@@H1]3C(=O)NC4=CC(C)=CN=C4Cl)N=C12 CCN(CC)CCC[C@H1](C)N=C1[NH1]C(=NC)[NH1]C(=NCC23CCC(CC2)OC3)[NH1]1 CCO[C@@H1]1C[C@H1]1C(=O)N[C@@H1](CCCNC(=O)C(C)=C(C)CC)C2=CC=CC=C2 CCS(=O)(=O)CC(=O)N1CC[C@@H1]1CNC(=O)C2=C(Cl)C=NN2C CC[C@@H1](CCOC)C(=O)N(C)C[C@H1]1CN(C(=O)C2=CN(C(C)C)C=C2C)CCO1 O=C(C1=CC=C2C(=C1)CCN(C(=O)C3=CC([N+1](=O)[O-1])=C(O)C=C3F)C2)N4CCC4 C[C@@H1](NC(=O)C1=CC=C(CNC(=O)[C@]2(C)CCCO2)N=C1)C(C)(C)CO C[C@H1](CC1CC1)C(=O)NC[C@H1]2CC[C@@H1](NC(=O)C3=C(C(F)(F)F)C=C[NH1]C3=N)C2 C#CC(C)(C)C(=O)NCC(=O)N1CCN(C(=O)C(=O)N2CC[C@@H1](C)C2)CC1 C=C=C(C)CC(=O)N[C@@H1]1CCC[C@@]1(C)CNC(=O)C2=CC=CC(=O)N2C CCO/C=C/C(=O)N1C[C@H1](C#N)[C@@H1](NC(=O)[C@H1](OC)C(CC)CC)C1 CC(=CC(=O)NC1CCN(C(=O)[C@@H1](C(C)C)N2C=NN=N2)CC1)C3CC3 COC[C@H1](C)CC(=O)N1CCC[C@@]2(CNC(=O)C=3SC=NC=3C)CCC[C@@H1]12 CCOC=1C=C(C(=O)N2C[C@@H1](C)C[C@@H1](NC(=O)C=CC3=CC=CC=N3)C2)ON=1 CCC=1[NH1]N=C(C(=O)NC2(CCCNC(=O)[C@H1](C)N3CCC[C@H1](O)C3)CC2)C=1C CC=1SC=C(C(=O)N2CCN(C(=O)CN3CCP(C)(=O)CC3)[C@@H1]4C[C@@H1]42)C=1C C[C@H1](C(=O)NC[C@H1]1CN(C(=O)CC2=CN=NN2C)CC1(F)F)C(F)(F)C(F)F C#CCCC[C@H1](C)C(=O)N1CC[C@@H1](CNC(=O)C2=CC=NC3=CC=CC=C23)C1 CCN(CCN1CCCC1)C(=O)[C@H1]2OCC[C@H1]2NC(=O)C=3N=NSC=3C CC(=O)C1=NC=C(C(=O)N2CC(OCCNC(=O)C3=CC=CN4N=NN=C34)C2)S1 O=C(C=C(Cl)Cl)NC1(CNC(=O)C2=CC=C([N+1](=O)[O-1])C=C2F)CCOCC1 C#CCSCC(=O)N[C@H1](CNC(=O)C1=CN=CC(C(C)(C)C)=C1)[C@@H1]2CCOC2 ClCN=C1[NH1]C(=NC[C@@H1]2C[C@H1]3C=CC[C@H1](C3)C2)C4=CC=C(C5=CC=CC=C5)C=C4[NH1]1 CC(=O)CCCC(=O)N1CC[C@H1](NC(=O)[C@@H1]2C[C@H1]2C=3C=CN(C)N=3)C1(C)C CCC(F)(F)CC(=O)N[C@@H1]1C[C@H1]2CN(C(=O)C3=CC4=CC=CN=C4C=C3F)C[C@@H1]21 CCNC(=O)CN(C)C(=O)C12CC(CN(C(=O)[C@@H1]3CCCO[C@@H1]3C)C1)C2 C=CC[C@@]1(NC(=O)CCC2=NN=CS2)CCN(C(=O)[C@@H1]3CCC4=CC=CC=C43)C1 C#CCC(=O)NCC1(C)CN(C(=O)C2=CC(S(N)(=O)=O)=CC([N+1](=O)[O-1])=C2Cl)C1 CC[C@H1](C(=O)NC[C@@]1(C(F)F)CCN(C(=O)C2=NC(C)=NN2C)C1)C(F)(F)F CC=1C=C(C)N(CC(=O)N2CCCC[C@@H1](NC(=O)[C@@H1]3CCSC3)C2)N=1 CCO[C@]1(C(=O)N2C[C@H1](CNC(=O)C3=CC(CC)=C(C)S3)C4(CC4)C2)CCOC1 CC(C)[C@H1](O)CNC(=O)[C@](C)(CO)NC(=O)CN1CC(=O)NC1=O CS[C@@H1](C(=O)N1CCC[C@@H1]1CN(C)C(=O)CCCCC2CCCCC2)C3CC3 CON=CC(=O)N1C[C@H1]2[C@@H1](C1)OCCN2C(=O)C3=CC(Cl)=NC(OC)=C3 COC(=O)NCCC(=O)N[C@H1]1CCC[C@H1](NC(=O)C(C)(C)C(=O)N(C)C)C1 O=C(N[C@H1]1[C@@H1]2CN(C(=O)C3(N4C=CN=N4)CC3)C[C@@H1]21)C5=CC=C6SC=NC6=C5 O=C(NC1=C(F)C=CC=C1F)C(=O)N2CC[C@H1](NC(=O)C3=CC(F)=C[NH1]3)[C@H1](F)C2 CCCC[C@@H1](NC(=O)C1=CC=CC2=C[NH1]N=C12)C(=O)N3CC[C@H1](CSC)C3 CC(=O)C1=CC=C(C(=O)NCCNC(=O)[C@]23CCCC[C@H1]2C3(F)F)O1 O=C(N[C@@H1]1CN(C(=O)CCN=C2[NH1]C=CS2)[C@H1]3C[C@H1]13)C4=CC=CC5=CN=CC=C45 C=C[C@@H1](C)CC(=O)N[C@@H1](CNC(=O)CCCOC1=CC=CC(Cl)=C1Cl)C(C)C CC[C@@H1](C(=O)N[C@H1]1C[C@@H1](NC(=O)C[C@@H1](CC)SC)C1)N2C=NC(C#N)=N2 NC1=CC=NC(C(=O)NC[C@@H1]2CN(C(=O)C3(CO)CCCCC3)CCCO2)=C1 CC1(C)[C@@H1](CC(=O)NC2(CC3CC3)CC2)C[C@H1]1NC(=O)C4=CN=C(Cl)S4 CCCCC(=O)N1CC(CCCCNC(=O)[C@@]2([C@@H1]3CCCCO3)CCCO2)C1 C[C@H1](CCNC(=O)C1=CSC(Cl)=N1)N(C)C(=O)C2=NC(C3CC3)=CS2 CCSC1CN(C(=O)[C@@]23C[C@@H1](CCO2)N(C(=O)CN4C=CN=C4C)C3)C1 C=CCCCC[C@@H1](C)N1CCC2=CC=CC([N+1](=O)[O-1])=C2C1 CCCCCCCN(C)C(=O)[C@@]12CCC[C@@H1]1CCN2C(=O)C#CC3CCC3 C=C[C@@H1](O)C(=O)N(C)C[C@@H1](CC1=CC=CC=C1)NC(=O)CSC(C)(C)C CCC(CC)CCC(=O)N[C@@H1]1CCN(C(=O)C=2C=NN(CC(C)C)C=2C)[C@H1](C)C1 C=CCC(=O)NCCC1CC(C(=O)N2CCN3N=CC([N+1](=O)[O-1])=C3C2)C1 CCCC(C)(C)CNC1(C2=NN=NN2C[C@@H1]3CCCO3)C[C@@H1]4CC=CC[C@H1]4C1 CN(CC(=O)N[C@H1]1CN(C=2C=CN3C(Br)=CN=C3N=2)CC(F)(F)C1)C(N)=O CNC1=CN=C(C(C)C)N=C1C(=O)N(C)C2CN(C(=O)[C@H1]3CC34CC4)C2 CCN(CC(=O)N1CCO[C@H1](C(=O)NCCC2=CCCCC2)CC1)C3CC3 C[C@H1](O)C[C@H1](C)N=C1[NH1]C2=C(C(=NCC3=CC=NN3C(F)F)[NH1]1)CSC2 C[C@@H1]1C[C@H1](C(=O)N(C)CC[C@@H1]2CCCN2C)N1C(=O)[C@H1]3CC(C)(C)CO3 COCC[C@H1](C)C(=O)N1CC[C@@]2(CCCN(C(=O)CN(C)S(N)(=O)=O)C2)C1 C#CC[C@@H1](C)C(=O)N[C@H1]1CCCC[C@H1]1N(C)C(=O)C2=CC=CC(OC(F)(F)F)=N2 C#C[C@@H1](C)N(C)C(=O)C[C@@H1](CNC(=O)C(C)(C)COC)C1CCC1 C[C@@H1]1SCCNC[C@H1]1N(C(=O)C=2N=C(Cl)SC=2Cl)C3=CC=CC=C3Br C[C@@H1](C(=O)N(C)C1CN(C(=O)C2=CN=CS2)C1)C3=CC=CC=N3 CCC=1C=C(CC(=O)N2C[C@@H1]3C[C@]3(CNC(=O)C4=CN=C(S)[NH1]4)C2)ON=1 CC[C@@H1](CNC(=O)CC=1[NH1]C=NC=1C)NC(=O)[C@@H1](C)S(N)(=O)=O CSC1(C(=O)N[C@@H1]2CCC[C@@H1](C(=O)NCC3=CON=C3C)C2)CC(=O)C1 CC1=CC=C(C2=NC(C(=O)N3CCSC[C@@H1]3C(C)(C)C)=CSC(=N)[NH1]2)S1 CC=1C=C(CCC(=O)NC[C@H1](O)CNC(=O)C=2N=C(Cl)OC=2C)ON=1 CCC1=NC=C(C(=O)N2CCC[C@H1](N3CCN(C(=O)C(C)(C)F)CC3=O)C2)S1 CO[C@@H1]1CCC[C@@](NC2=CC=CC(Cl)=C2)(C3=NN=NN3C4COC4)CC1 CC(C)CCCCC(=O)NC[C@H1](CO)CNC(=O)C[C@@H1]1CC2(CCC2)CO1 C1[C@H1]N(C(=O)C(=O)N2CC[C@](O)(C(F)(F)C(=O)NC)C2)CCC1(C)C C/C=C/CCCCC(=O)N1CC[C@H1](C(=O)N[C@@H1](C)CN(CC)CC)C1(C)C C[C@H1]C1CC(Cl)=C(C(=O)N2CCN(C(=O)C3=C[NH1]C(=S)C=N3)C[C@H1]2C=4C=N[NH1]C=4)C1 CC(C)C[C@@](C)(O)C(=O)N1CC[C@@H1](CNC(=O)CC23CCC(CC2)CC3)C1 C#CC1(C(=O)NC[C@@]2(CNC(=O)C3=CC4=CN=CC=C4C=C3F)CC2(F)F)CC1 O=C(N[C@]1(CF)CCN(C(=O)C2=COC(Cl)=C2)C1)[C@@H1]3[C@H1]4CC5=CC=CC=C5[C@H1]43 CC1=CC=NN1[C@H1](C)C(=O)N2CC[C@]3(C[C@H1]3C(=O)NCCSCCCO)C2 C=C(Br)CNS(=O)(=O)C1=CC=C(N2C[C@H1]3[C@@H1](O)CC[C@H1]3C2)C(Br)=C1 CC=1C=CC(=N)[NH1]C=1C(=O)N[C@@H1]2C[C@H1](C)N(C(=O)OCC3=CC=C(Cl)C(Cl)=C3)C2 C[C@H1](CCCNC(=O)C1=C(Cl)CCC1)NC(=O)C2=NN=C3N2CCCC3 C[C@@H1](C(=O)NCCCNS(C)(=O)=O)N(C)C(=O)C1=CC=C(N)C(F)=N1 CC=1C=NOC=1C(=O)NC[C@@](C)(NC(=O)C2=C(C3=CC=CC=C3)N=NN2C)C4CC4 CC1=CC=CC(N2CCN(C(=O)C(=O)N3CC[C@H1](C4=NC=NO4)C3)CC2)=C1 C[C@@H1]1CCN(C(=O)C=C2CCSCC2)C[C@@H1]1N(C)C(=O)[C@@H1]3CC4CCC3CC4 C#C[C@]1(C(=O)NC2=CN=C(N3CCOCC3)N=C2)CCNC1 C=CCCCCC(=O)N1CCOC[C@@H1]1CN(C)C(=O)C2CCCC2 CC1=C(C(=O)N2CCN(C(=O)C3(C)CC(C)C3)C[C@@H1]2C)C=NC4=NC=NN14 CN1C(=O)CCC[C@H1]1C(=O)N[C@@H1]2CCN(C(=O)C3=NN=C(Cl)C=C3N)C2 CCC1=CC(Br)=CC=C1CN2CC[C@]3(C[C@@H1]3C(=O)N(CCC#N)CC(F)(F)F)C2 CC=CC(=O)N[C@H1](CCCC)CNC(=O)C[C@@H1](O)C1=NC2=CC=CC=C2[NH1]1 CCCC[C@@H1](O)C(=O)NC[C@H1](CNC(=O)C1(N2C=NN=N2)CC1)OC COCCN1N=CC=C1C(=O)NCC=2N=C3N=CC=CN3N=2 CC(C)CCO[C@H1](C)C(=O)N(C)C/C=C/C(=O)N1CCN2CCC1CC2 CCC1(CNC(=NCC2=CC(OC)=CC=C2O)NCC(=O)NC(C)C)CC1 CCC(F)(F)CC(=O)NC[C@@H1]1CCC12CCN(C(=O)C=3C=CN(CC#N)N=3)CC2 C=C=C(C)CC(=O)N1C[C@@H1]2C[C@H1]1C[C@H1]2CNC(=O)[C@@H1]3CCCO3 COC1=CC=C(OC)C(C(=O)N[C@@H1]2COC3(CCN(C(=O)C(N)=O)CC3)C2)=C1 CCCC(=O)N(C)C[C@H1]1CCCCN1C(=O)C=2SC(C)=CC=2C CC(C)[C@H1]1C[C@@H1](C(=O)NC(C)(C)CCCNC(=O)COCC2CC2)CCO1 CO[C@@H1](CO)CN=C(NCC(=O)NC(C)C)N[C@H1](C)C1=CC=CC2=CC=CC=C12 C[C@H1](C(=O)N[C@@H1]1C[C@H1]1NC(=O)C2=CN=C(N)C(Cl)=C2)N3C=NC4=CC=CC=C43 CCCN(CCC)CCNC(=O)[C@H1]1CC=C[C@H1](NC(=O)C2CCC3(CC2)CC3)C1 C[C@H1](CN1C=CC=N1)C(=O)N2[C@H1]3C[C@@H1]3C[C@@H1]2C(=O)NC4=NC=CC(F)=C4F CCC=1C=CSC=1C(=O)N2C[C@H1]3[C@@H1](C2)[C@@H1]3C(=O)N4CC(C#N)(SC)C4 CC1=CC(Br)=CC(Cl)=C1NC(=O)[C@@H1]2C[C@H1](F)CN(S(=O)(=O)C=3C=NOC=3C)C2 CN(C[C@H1]1COCCN1C(=O)C2=CSN=C2Cl)C(=O)C(=O)NCC(F)F O=S(=O)(CC[C@@H1]1CCCOC1)N[C@H1](C2CC2)[C@H1]3CCCNC3 O=C1CC[C@@H1](C(=O)NCC23CCC(CC2)N(C(=O)[C@@]4(F)CCOC4)C3)O1 CC[C@]1(C)CC[C@@H1](C(=O)NCCCCCCNC(=O)C2=CC=C(C)N=C2)O1 CC(=O)O[C@H1](C(=O)NCC1(CNC(=O)[C@@H1]2CC23CC3)CCOCC1)C(F)(F)F CC[C@H1](C)N(C(=O)C1=CC=C(C2=CC=C(OC)C(I)=C2)C=C1)[C@@H1](C)CC CCN(C[C@H1](C)NC(=O)/C(C)=C/C1=CC=C(Cl)C=C1)C(=O)CCCSC COC=1SC=CC=1C(=O)N[C@@H1]2CC[C@@H1]2NC(=O)C3=CSC4=CC=CN=C34 CC1=CC([N+1](=O)[O-1])=CC=C1C(=O)N[C@H1]2CCN(CC3=CN=CC=C3Cl)C[C@H1]2C CCC1=CC=CC(F)=C1C(=O)N[C@H1]2CN(C(=O)CN3C=CN=C3C)C[C@@H1]2C CC1CCC(C)(C(=O)N(C)CCNC(=O)C=2C=N[NH1]C=2)CC1 C=CCCC(=O)N[C@@H1](CC)CN(CC)C(=O)CCCN[NH1]C=CC(=O)N(C)C=O C[C@H1](CC(=O)NC[C@]1(F)C[C@H1](NC(=O)CN2CCCCS2(=O)=O)C1)NC(N)=O CO[C@H1](C)C(=O)N[C@@H1]1CCCN(C(=O)C2=CC=C(F)C(F)=C2Cl)C1 CSCC[C@H1](O)C(=O)N1[C@H1]2CC[C@@H1]1C[C@H1](CNC(=O)[C@H1](C)OC3CCCC3)C2 CC(C)/C=C/CCC(=O)N1C[C@H1]2CC[C@]2(CNC(=O)CCNS(C)(=O)=O)C1 C[C@H1](CF)C(=O)N[C@H1]1CCCCC[C@@H1]1NC(=O)C=2SC=CC=2C#N COCCOC1=CC=NC(N[C@H1](C)C[C@@H1](C)NC(=O)C=C2CC[C@H1](C)C2)=N1 COC1=CC=CC(Br)=C1C(=O)N(C)[C@H1]2CCCN(C(=O)COCCF)C2 C#CC[C@@](C)(NC(=O)C=CC=1C=NN(C)C=1)C(=O)N[C@@H1]2C(=O)NCC2(C)C CCC1=CC=C(NC(=O)C2=C(C)[NH1]C(C(=O)NC3=CN(C)N=C3C)=C2C)C=N1 N#CC1=C(F)C=CC(NC(=O)N(CC2=CC=CC(Br)=C2)C3CC3)=C1F COCCSCC(=O)N[C@@H1]1C[C@@H1](NC(=O)C2=CN(C(F)F)C=N2)C[C@H1]1O CSC1CC(CNC(=O)[C@H1]2CN(C(=O)[C@H1]3CCC(F)(F)C3)CC4=CC=CN4C2)C1 CC1=CC=C(C(=O)N2CC(C)(NC(=O)COCCC3CCCC3)C2)C(F)=C1Br COC[C@@H1](CC(=O)NOC[C@H1](C)O)NC(=O)CCC=1C=CN(C)C=1 CCN1C=C(CC2=NC(C(C)C)=NN2C3=CC=C(F)C=C3C)C4=CC=CC=C41 O=C(CCCC1=CC=CC=N1)NC[C@@H1]2C[C@@H1]3OCC[C@H1]3N2C(=O)[C@@H1]4C=CCC4 O=C(CO[C@H1]1CCN(C(=O)C[C@@]2(O)CCCOC2)C1)NC[C@H1]3C[C@@H1](O)C34CCC4 CC=1C(C(=O)N2C[C@@H1]3CC(NC(=O)C4(C#N)CCOCC4)C[C@H1]3C2)=NN(C)C=1N C[C@@H1]1CN(C(=O)CCC2=COC=N2)CC[C@@H1]1NC(=O)[C@H1](C)C=3C=C[NH1]N=3 C[C@@H1](NC(=O)C12CC3C[C@H1]1[C@H1]2C3)C4CCN(C(=O)[C@@H1]5CC=C[C@H1](O)C5)CC4 CN1CCC[C@@H1]2CCN(C(=O)[C@]3(C)CCCN(C4=CC=CC(F)=N4)C3)C[C@H1]21 COCCS(=O)(=O)N1C[C@H1](O)C[C@H1]1C(=O)NCC2=CN=C(C)N2C CC[C@H1](C)C1=CC=C([C@@H1](C(=O)NCCC#N)N2CC[C@H1](C3=CC(C)=NO3)C2)C=C1 C=CCC1(C(=O)N[C@H1]2CC[C@@H1](C)N(C(=O)CC3=CC=C(Cl)C=C3[N+1](=O)[O-1])C2)CC1 COCC1=CC(C(=O)NC[C@@]23CC[C@@H1](CN(C(=O)[C@H1](C)OCC(C)C)C2)C3)=NO1 CC1(C)[C@H1](C(=O)NCC2=NN=C(C3CCN(C4=NN=NN4C)CC3)S2)C1(F)F CC[C@@H1](C(=O)O)N(C)C(=O)C[C@H1]1CCN(C(=O)[C@@H1](CC)SC)C1 CC(C)[C@H1](C)CC(=O)N1[C@H1]2CC[C@H1]1CC(C(=O)NCCC3=NC=CN3C)C2 CC(C)S[C@@H1](C)C(=O)NC[C@@]1(O)CCN(C(=O)CC2=CC=C(F)C=C2Cl)C1 C#CCOCCOCCOCC(=O)N1C[C@@H1](CNC(=O)C2(C)CCC2)CC1(C)C CC1(F)CC2(CN(C(=O)[C@@H1]3CCCN3NC(=O)C45CC(F)(C4)C5)C2)C1 CC[S@@](=O)CC(=O)N1[C@H1](C)CC[C@@H1]1C(=O)N[C@@H1](C)CSC COC[C@H1](C)C(=O)N(C)[C@@H1](CNC(=O)CN1N=NN=C1C)C2CC2 CC[C@H1](C[C@@H1](C)O)NC(=O)[C@H1](NC(=O)C1=CC=CC(NC)=N1)C2=CC=CS2 N#CC1=CN=CC(N2CC3(CO[C@@H1](CNC(=O)CCCCO)C3)C2)=N1 N=C1[NH1]C(C2CC2)=C(C(=O)NC[C@@H1](O)CNC(=O)C3=CC4=C(C=N3)COCC4)S1 CC(=O)OC[C@@H1]1CCN(C(=O)C2C[C@@H1]3CC[C@H1](C2)N3C(=O)[C@@H1](C)C(C)C)C1 CN1N=C(C2CCCC2)C=C1C(=O)N(CCO)CCCNC(=O)C3CC(F)C3 COCCN1C[C@@H1](C(=O)NCCCCC=2C=C[NH1]C=2)CC1=O O=C(CC1(O)CCC1)NCC[C@@H1]2CC[C@H1](NC(=O)C3=CC=C([N+1](=O)[O-1])C(Cl)=C3)C2 CN=C1[NH1]N=C(CC(=O)N2C[C@H1]3C[C@H1]2CCN3C(=O)CNC(=O)C(C)(C)C)S1 O=C(NCCC1CC(O)C1)NCC2=CC=C(OC(F)(F)C(F)F)C(F)=C2 C=CC1=CN=CC([C@@H1](NCC#CC2CC2)C3=NN=NN3CCCOCC4CC4)=C1 C#CCCC[C@H1](C)C(=O)NC1CC(O)(CNC(=O)[C@H1](C)SCC)C1 C=CCC(=O)N1C[C@H1](C)[C@@H1]1C(=O)NCCN2CC[C@H1](CO)C2 O=C(C[C@@H1]1CC[C@H1]2COCC[C@@H1]2C1)OCC3=NN=C4C(Cl)=CC=CN34 CC1=NN2C(C(=O)N3CC(CO)(NC(=O)C=4C=COC=4C5CC5)C3)=C(C)N=C2S1 CCCOCCC(=O)NC[C@@H1](NC(=O)[C@@H1]1CC12CC2)C3=CC=CC=C3 CC[C@@H1](CC(=O)N1C[C@@H1](CNC(=O)C2=CC(OC)=NC=N2)CC1(C)C)OC CCOCCCC(=O)N(CCNC(=O)C1(C2(O)CCOCC2)CC1)C[C@@H1](C)O C[C@@H1](CS(C)(=O)=O)C(=O)N(CCO)[C@H1]1CCCN(C(=O)C2=CN=C[NH1]2)C1 NC1=CC(F)=CC=C1C(=O)N2CC(CN3C=C(CO[C@@H1]4CCOC4)N=N3)C2 O=C(C1=CC=CN2C=CN=C12)N3CC4CC3(C(=O)N[C@@H1]5CC[C@H1]6CC[C@H1]65)C4 CCN(CC1CC1)C(=O)[C@H1]2CC[C@H1](CNC(=O)[C@H1](F)CCC(C)C)CC2 O=C(CC1=CC=NC=C1Cl)N2CCN(C(=O)[C@@H1]3CCCOCC3)[C@@H1](CO)C2 CCCSCC(=O)NC[C@H1]1C[C@H1]2C[C@@H1](C1)N(C(=O)C3=CC=CC4=C3OCCC4)C2 C=CC1(C(=O)NCC[C@@H1](C)N(C)C(=O)[C@H1](O)C2CCOCC2)CCC1 COC[C@@H1](C)CC(=O)N[C@H1]1CCN(C(=O)CC(C)(C)C2CC2)[C@@H1]1C(C)C CC(C)(C#CC1=CN(CCOC2CCCCC2)N=N1)NC(=O)C3=NO[C@H1](CO)C3 C#C[C@@H1](CNC(=O)[C@H1](CCC1CCC1)NC(=O)CN2CCNC2=O)C(C)C COCC=1N=N[NH1]C=1C(=O)N[C@H1]2CCN(C(=O)C3=C(C)C=C(O)N=C3C)C[C@@H1]2O C#CC1=CC=CC(C2(C(=O)N(C)C3=CC=CC(C(N)=O)=C3)CCC2)=C1 CCN1N=CC(C)=C1C(=O)NCC2=CC(C(=O)N(C)[C@H1]3C[C@@H1]3C)=CO2 COCCC(=O)N[C@H1](C)CC1CN(C(=O)[C@@H1]2C[C@H1]2C3=CC=CC=C3F)C1 CC[C@@H1]1CN(C(=O)[C@@H1]2CSCN2C(C)=O)CC[C@@H1]1NC(=O)[C@H1](C)SC(C)C CC(=O)N1CCO[C@@H1](CNC(=O)N=C2C=CC(C(C)C)=N[NH1]2)C1 COC(=O)[C@H1]1CCC[C@@H1](C(=O)N[C@H1](C)CN(C)C(=O)C2(C3CCC3)CC2)C1 CC(C)NC(=O)NC1=CC=C(S(=O)(=O)N[C@H1]2CC3CCC2CC3)C(Cl)=C1 CCCC[C@@H1](C)C(=O)N1C[C@@H1]2CC(NC(=O)C3(C(C)C)CC3)C[C@H1]2C1 O=C1CCC(CCC(=O)N2CCOC[C@H1]2CNC(=O)[C@@H1](F)C3=CC=CC=C3)=NN1 C[C@H1](NC(=O)C1=CN=C2N1CCCC2)[C@@H1](C)NC(=O)C3=C(F)C=CC4=C3OCC4 C[C@H1]1C[C@H1](CNC(=O)C=2SC=CC=2C#N)CN1C(=O)C3=CC(Cl)=C(Cl)S3 C1CC=CC=C(C(=O)N2CCC[C@@H1]2/C=C/C(=O)N(C)CP(C)(C)=O)S1 CC(C)(C)[C@@H1](NC(=O)C1([C@H1]2CCCO2)CC1)C3=CC=CC=C3 CC(C)OC1=N[NH1]C=C1C(=O)N2C[C@@H1]3C[C@H1]2C[C@H1](NC(=O)C=4SC=CC=4F)C3 CSC1=CN(C)N=C1C(=O)NC[C@@](C)(CC(C)C)NC(=O)CC=C(Cl)Cl C1=CN=C2C=CC(C3=NC(C4CCCC4)=NN3C5=CN=CC(C)=C5)=CC2=C1 COC(C)(C)CCC(=O)NCCCNC(=O)[C@]1(N(C)C)CCCOC1 CCOC1=CC=C(CC(=O)N[C@]2(C)CCN(C(=O)[C@@H1](C(C)C)N(C)C)C2)C=C1 CCC1=C[NH1]N=C1C(=O)N2CC[C@H1](C)[C@H1](NC(=O)C3=C(C)N=C(C)N3O)C2 O=C(N[C@@H1]1C[C@H1]2CC[C@@H1]1[C@H1]3CN(C(=O)[C@H1]4C[C@@H1](F)C4)C[C@@H1]23)[C@H1]5CCOC5 CCCC[C@H1](O)[C@@H1](C)C(=O)N1CCOC[C@@H1]1CN(C)C(=O)C(C)(C)CCC CCCN(CCNC(=O)C[C@H1](C)C(C)(C)C)C(=O)[C@H1](C)C#N CCOC(=O)[C@@H1](OC(=O)CC1=CC=CC(OCC2=CC=CC=C2Cl)=C1)[C@H1](C)CC CC1=CC(=N)[NH1]C=C1C(=O)N2CC[C@@H1]3CN(C(=O)[C@@H1](C)C(F)(F)F)C[C@@H1]3C2 O=C(CCOC1=CC=C(F)C=C1)NCCN(CC2=CC=C(Cl)N=C2)C(=O)C3CC3 CC(C)(C#N)CNC(=O)[C@]1(NC(=O)C[C@H1]2CC2(C)C)C[C@@H1](O)C1 CN(C(=O)CN1C=C(C2=CC=CC(F)=C2)N=N1)[C@H1]3CCN4CCCC[C@@H1]34 CC=1C=NSC=1C(=O)N2CC[C@@H1](NC(=O)C3=NC(O)=C4C=CC=CC4=C3C)C2 C=CCC1(C(=O)NC[C@H1]2[C@@H1]3CN(C(=O)C[C@@](C)(O)CCC)C[C@H1]23)CCOCC1 CN1N=CC2=C(O)C=C(C(=O)N[C@@H1]3[C@H1]4CCN(C(=O)CC=5N=C[NH1]N=5)[C@H1]43)C=C21 CC1=CC=C(C(=O)NCC[C@@H1]2CCN(C(=O)C[C@H1](C)C3CC3)C2)S1 CC[C@@H1](C(=O)N1C[C@H1](C)C[C@H1](CNC(=O)[C@]2(F)CCOC2)C1)N3N=CC=C3C CC(C)(C)[C@@H1]1CCN(C(=O)C[C@@H1]2CCSC2)C[C@H1]1NC(=O)C=3C=CSN=3 CCCN(CC1=CC=CN=C1)C(=O)CCN2CCNC[C@H1]2C O=C(CNC(=O)C1=CC=C(F)C=C1Br)NC[C@@H1]2CCCCN2C3CC3 CCCC=CC(=O)N[C@@H1]1C[C@H1](NC(=O)C2=CC(CCC)=C(C)S2)C13CCC3 C[C@@H1](C(=O)N1CCC2(CCN(C(=O)[C@H1]3CCS3(=O)=O)CC2)C1)N4C=CN=N4 CCC(C)(C)C(=O)N[C@H1]1CCCCCN(C(=O)[C@]2(N(C)C)CCCOC2)C1 CCN1C=C(CC(=O)N2C[C@@H1](CC(=O)NCCOCCC(C)C)C3(CC3)C2)C=N1 CC[C@H1](NC(=O)C=1SC(NC(=O)C2=CC=CN=C2Cl)=NC=1C)[C@@H1](C)O CCC[C@@H1](C#N)C(=O)N1C[C@H1](NC(=O)C2=CSC3=CN=CN23)[C@H1](OC)C1 C[C@H1]1CCN2C=C(C(=O)NCC(C)(C)CNC(=O)C3=CC=CC=C3Cl)N=C2C1 CC[C@H1](O)C1=CN(CCCNC(=O)C2=CC=C3C=COC3=C2)N=N1 CC1=CC(C(=O)N2CC[C@@H1](NC(=O)C(C)C)[C@@H1](C)C2)=C(C)N1C[C@@H1]3CCCOC3 C#CC1=CC=NC(C(=O)NCCC[C@H1](C)NC(=O)C2=C(Br)C=NN2CC)=C1 CC[C@H1](C)[C@@H1](CC(=O)NCCCC1CCCC1)NC(=O)C2=CC(C)=NN2CC CCC[C@@]1(NC(=O)N2CCC3(CC2)C[C@@H1](O)CCO3)CCNC1=O CC[C@@H1](C)CC[C@@H1](O)CC(=O)N1CC2(NC(=O)C3OCCCO3)CCC1CC2 CCC1=NC=C(C(=O)NCC2=CC(C(=O)NCCN(C(C)C)C3CC3)=CC=N2)O1 C[C@]1(CNC(=O)[C@@H1]2CCC[C@H1](CF)C2)CN(C(=O)C3CCC4(CC3)CC4)CCO1 C#CC[C@@](C)(NC(=O)C1=NON=C1CC)C(=O)NCC(C)(C)C[C@@H1](C)O CC1=NC(C)=C(C(=O)N2CC3(CO[C@H1](CNC(=O)[C@H1]4CCCNC4=O)C3)C2)O1 O=S(=O)(CCC1CCCCC1)N2CCN(CC3=NNN=N3)CC2 O=C(C[C@@H1]1CCCS(=O)(=O)C1)NCC2(NC(=O)C=3C=NN4C=3OCC4)CC2 CCCCNC(=O)[C@@H1](C1=COC2=CC=CC=C12)N(CCOC)CC3CCSCC3 O=C(NC[C@@H1](O)C(=O)N[C@H1]1CCCC[C@H1]1CCO)C=2C=C3N(N=2)CCC3 CCN(CC)CCC(=O)N1CCC([C@H1](C)C(=O)NC(C)(C)CCO)CC1 CN1N=C(C(=O)N[C@H1]2CCN(C(=O)C=3N=N[NH1]C=3Cl)C2)C(Cl)=C1C(F)(F)F CN1N=CC(Cl)=C1C(=O)N[C@@H1]2CCCC[C@@H1]2CNC(=O)[C@H1](F)C(F)(F)C(F)(F)F CC(C)(CCNC(=O)C#C[C@@H1]1CCCOC1)NC(=O)[C@@H1]2CN3CCN2CC3 COC1=CC(C2CN(C(=O)OCC3=CC=CC=C3)C2)=CC(Cl)=C1OCC#N C[C@H1]1CCCC=C1C(=O)NC[C@@H1](CO)NC(=O)C=2C=C[NH1]C(=N)C=2 COC1=CC=C(C=2N=C(C3=CC4=CC=C(F)C=C4[NH1]3)N(CCOC(C)C)N=2)N=C1 O=C([C@@H1]1CCCN(CC(F)F)C1)N2CCN(C[C@H1](O)C3=CC=CC=C3)CC2 C[C@H1](CCC(C)(C)C)C(=O)NCCN(C)C(=O)CCCC(F)F CCC1=CC=CC(C(=O)N[C@@H1](CC)CCCC(=O)N2CC(OC)C2)=C1 C=CCOCC(=O)N1[C@H1]2CC[C@H1]1CC(NC(=O)C34CC(C)(C3)OC4(C)C)C2 C[C@@]1(CN=C2C=CN=C(NC[C@H1]3CNC(=O)C3(F)F)[NH1]2)CCCCC1(F)F O=C(CCN1C=NC=N1)N[C@H1]2C[C@H1](C(=O)NC[C@H1]3CC[C@H1](CO)CC3)C2 O=C(N[C@H1]1CCN(C(=O)C2=CC=C3C(=N2)CCC3)CC[C@@H1]1CO)C4CSC4 C[C@@H1](NC(=O)CN1C=CN=N1)[C@@H1]2CCCN(C(=O)/C=C/C3=CC=C([N+1](=O)[O-1])O3)C2 C[C@@H1](CNC(=O)[C@H1]1CCCC[C@H1]1CNC(=O)C2=CC=CN=C2)C3=NC=C[NH1]3 CC1=CC(NC(=O)C[C@H1]2CCC[C@H1]2C)=CC=C1NC(=O)C(F)(F)C3=CSC=N3 CCC1=NSC(N2CCC[C@H1]2CN(C)C(=O)[C@H1](C)N3CCSCC3)=N1 CC(C)CCO[C@@H1](C)C(=O)N[C@@]1(C)CCN(C(=O)C2=CC=NC3=CC=NN23)C1 COC[C@@H1](C)[C@H1](C)C(=O)N(CCO)CCC(=O)NC1CCSCC1 CC1=CC(N(C)CC2=CC=C(F)C(Cl)=C2)=NC=C1S(=O)(=O)NC[C@H1]3CCCS3 C=C[C@@H1](O)C(=O)N1CCC([C@@H1]2CCN(C(=O)CCC3=CC=C(O)C(Cl)=C3)C2)CC1 CCCC=1N=COC=1C(=O)N[C@@H1]2C[C@H1]3CN(C(=O)C4=CSC(=NC)[NH1]4)C[C@H1]32 CN(C[C@@H1](O)CN(C)C(=O)C1=CC(O)=CC(N)=C1Cl)C(=O)C=2C=CN(C3CC3)N=2 CC1(C(=O)NC2CC3(CCC(NC(=O)CC=4C=CSC=4C)CC3)C2)CCOCC1 O=C(NC[C@@H1](NC(=O)C1(F)CCOCC1)C2CCCCC2)[C@@H1]3CCS(=O)(=O)N3 CC1(C)OCC[C@@H1]1NC(=O)[C@H1]2NCC23CCC3 CC(=CC1=CC=CS1)C(=O)N2CCC[C@@H1]3[C@@H1]2CCCN3C(=O)CN4CCOCC4 O=C(NC[C@H1](O)CCNC(=O)[C@@H1]1CN2CCN1CC2)C3=CC=NN3CC4CCC4 C[C@@H1](/C=C/C(=O)NC[C@H1]1CCCN1C)NC(=O)CCN2C=NC(=N)[NH1]2 COCCO[C@H1](C)C(=O)NCCOCCN(C)C(=O)C1=C(Cl)C=CC(C)=C1O COC1=C(C(=O)N[C@@H1]2C[C@H1]3[C@@H1]2CCN3C(=O)C4CCN(C)CC4)C=CC(Cl)=C1Cl CCC1=NC(C(F)(F)F)=C(C(=O)NC[C@H1](C)CNC(=O)[C@@H1](O)C2CCCC2)S1 COC(=O)[C@H1](C)NC(=O)[C@H1](C1=CC=C2C(C=CN2C)=C1)N3C[C@H1](C)[C@H1](O)C3 CCCC=C(CC)C(=O)N1CCN(C(=O)[C@H1](C)OCC2CC2)[C@H1](CC(F)(F)F)C1 CN(C(=O)C(F)=CC1=CC=CN=C1)C2CC(NC(=O)C=3C=NN(C4CC4)C=3)C2 CCO[C@@H1]1C[C@@H1]2CN(C(=O)C=3C=C(CCNC(=O)CN4C=CN=N4)ON=3)C[C@H1]21 COC1=CC=C(C(=O)NC[C@@H1]2CCCC[C@@H1]2NC(=O)[C@@H1]3CCC4(CCC4)O3)N=N1 C#CCOCCC(=O)NO[C@H1](CC(C)C)C(=O)N1CCN(C)C2(CC2)C1 C#CC=CC=CCNC(=O)[C@H1](C)[N+1](=O)[O-1] CSC1=NC=C(Cl)C(C(=O)N[C@H1]2CN(C(=O)C=3C=NON=3)C[C@@H1]2C#N)=N1 COC[C@@]1(C)CCN(C(=O)C(=O)NC2=CC=C(C)C(C)=C2)C1 CCC[C@H1]1CNCCN1S(=O)(=O)C2=CC=CC(C3=CC=CC=C3C)=C2 CCOC(=O)[C@H1](NC(=O)C[C@]1(C2CC2)CCNC1)C(C)C CCCC1=CC=C(C(=O)N[C@@H1]2CCCN(C(=O)C3=CC=CC=C3[N+1](=O)[O-1])[C@@H1]2C)[NH1]1 CC[C@@H1](C(=O)OC)N(C)C(=O)C[C@@H1]1CN(C(=O)[C@]2(C)CCC[C@H1]2O)CC[C@H1]1C CN(C)[C@H1]1C[C@H1](C(=O)N[C@@H1]2CN(C(=O)C=3C=C(S(N)(=O)=O)N(C)C=3)C[C@H1]2O)C1 CCCOCCCC(=O)N[C@@H1]1CCC[C@@H1](NC(=O)[C@@H1]2CCCN3C=CN=C32)C1 COC(=O)C1=CC(C)=C(C(=O)N2CCN(C(=O)C3=CC=C(C)S3)C[C@](C)(F)C2)O1 N#CC1=CC=C(N2C[C@@H1]3[C@@H1](C[C@H1]3NC(=O)C4=CN=C5N=CNN5C4)C2)C=N1 CN(C)C1=CC(C(=O)N[C@H1]2C[C@@H1]2C3CCN(C(=O)[C@H1](O)CC(N)=O)CC3)=CC=N1 CCN(CCN(CC)C(=O)CCN(C)CCO)C(=O)C1CC(F)C1 C=CC[C@@H1](CNC(=O)C1=CSC2=C(OC)C=CC=C12)NC(=O)[C@@H1]3C=CCCC3 CC1=CC(N)=C(C)N=C1C(=O)N2C[C@H1](O)[C@H1](NC(=O)[C@H1]3CCN4N=CN=C4C3)C2 CC[C@]1(C(=O)NC2=NC=C(C3=CC=CC(Br)=C3)S2)CCNC1 CC(=O)NC[C@@H1]1CCC[C@H1]1NC(=O)[C@@H1]2C[C@@H1]2C3=CC=CC=C3 C#C[C@@H1]1CN(C(=O)C[C@@H1]2CC3(CC3)CO2)CCN1C(=O)CC[C@H1](C)SC CN(C)C1=CC=C(F)C=C1NC(=O)N2CCC(OC3=CC=C(F)N=C3)CC2 CS(=O)(=O)NCC(=O)N1CC[C@@]2(NC(=O)C3=CC=C(C#N)C(F)=C3)C[C@H1]2C1 C[C@@H1](CNC(=O)[C@@H1](C)C1=CC=CS1)CN(C)C(=O)C2=CC=CC(C(=O)C3CC3)=C2 C[C@H1](NC(=O)CSCCNC(=O)CCC1=CN=CN=C1)C2=CC=NS2 O=C(C1=CC(F)=C(F)C(F)=C1)N(O)CC2=CN(CCOCC3CCCC3)N=N2 CC(C)(C(=O)N1CC[C@]2(CCCN2C(=O)[C@H1]3CCS(=O)(=O)C3(C)C)C1)C(F)(F)F CC[C@@H1](C(=O)N1CCC([C@H1](O)CNC(=O)CSC)CC1)C(C)C CC1=C(N=[N+1]=[N-1])C=CC=C1NC(=O)C[C@@H1]2C[C@@H1](OC(C)(C)C)C2(C)C CC(=CC(=O)NC[C@@H1](O)C1CC1)CNC(=O)CC2=CN=NN2C O=C(C[C@@H1]1C[C@H1]1C2CC2)NC3(CCNC(=O)C4CC5(CSC5)C4)CC3 C#CCC1(C(=O)N2CCN(C(=O)[C@H1]3CC[C@H1](C)S3)CC2)CCC1 C[C@H1](CC(F)F)C(=O)N1CCC[C@](F)(CNC(=O)C(C)(F)F)C1 CC1CCC(=CC(=O)N2CCC(N(C)C(=O)C3=CN=NC(C4CC4)=C3)CC2)CC1 O=C(CCOC1=CC=C(Cl)C=C1Cl)NC[C@@H1]2C[C@H1]2CNC(=O)C(=O)NCC3CC3 O=C([C@@H1]1CC[C@@H1](O)C1)N2CC(N3CCN(C(=O)C=4C=CN5C=NC=C5C=4)CC3)C2 CCC[C@H1](CCCNC(=O)C=1C=NN(C(C)C)C=1C)NC(=O)C(F)(F)CF O=C(C1=CN=C2C(=C1)COC2)N3CC[C@@H1](N4CCN(C(=O)C5SCCS5)CC4)C3 COC1=N[NH1]C=C1C(=O)N(C2CC2)[C@H1](C)C(=O)N[C@H1]3C[C@H1]4CC[C@H1]3N(C)C4 CN(C(=O)C[C@H1](NC(=O)C=CC=1C=NN(C)C=1)C(F)F)C2CC(F)(F)C2 CSC1=NC=C(C(=O)N[C@@H1](C)CCNC(=O)[C@H1]2C[C@H1]3CC[C@@H1]([C@@H1]2C)N3CCO)S1 C#CC1=CC(F)=CC(NC(=O)[C@@H1]2CN(C(=O)C3=CC(C)(C)C3)C[C@H1]2F)=C1 CCO[C@H1](C)C1=NC(CC(=O)N(C)CCCCN(C)C(=O)CC(C)(C)COC)=CS1 CNC(=O)CCCCNC(=O)[C@@]12C[C@@H1](CCO1)N(C(=O)CN3C=CC=NC3=O)C2 O=C(C[C@H1]1CCCCN1C(=O)[C@H1]2CCO2)NC3=CN=C(F)N=C3 C[C@H1](CC(N)=O)C(=O)N[C@H1]1CCC[C@@H1](NC(=O)C2=CCC(F)(F)CC2)C1 CN(C)CC(C)(C)CC(=O)N[C@@H1]1CC[C@H1](CCC(=O)N[C@]2(C)CCCC2(F)F)C1 CCCCCC(=O)N[C@H1]1CC[C@H1](CNC(=O)C2=CC=C3C(=C2)[C@H1](C)CN3)CC1 O=C(NC1=CC(Cl)=CC(Br)=N1)NC2(C3=CC=CC(F)=C3)CCOCC2 CC1=NC=CC=C1[C@H1](C)NC(=O)[C@@H1]2CN(C(=O)[C@H1]3CC4=NC=CN4C3)C(C)(C)C2 CC1=NC=NC(C)=C1OCC(=O)N[C@@H1](C)C2CN(C(=O)[C@H1]3C[C@@H1](C)CO3)C2 COC1=CC=CC(CC(=O)NC[C@@H1]2COCCN(C(=O)C3(SC)CCC3)C2)=C1F CC(C)[C@@](F)(CNC(=O)[C@@H1]1CCO[C@@H1]1C2CC2)C(=O)NCC=3C=NN(C)C=3 CCCN1C=C(C(=O)NC[C@@H1](NC(=O)CC2CCN(OC)CC2)C(C)(C)C)N=N1 CN(C[C@@H1]1C[C@H1](F)CN1C(=O)C=2C=C([C@@H1]3CCOC3)[NH1]N=2)C(=O)C=4C=CSN=4 CC(C)[C@H1](C(=O)NC[C@@H1]1CC(F)(F)CN1C(=O)[C@H1]2CC=CCO2)N(C)C CC1=CC=C(C)N1CCC(=O)N[C@H1]2CCCC[C@@H1]2NC(=O)CC=3N=C[NH1]N=3 C=CC1(CC(=O)N2CC(CCNC(=O)CCN3C=CC=CC3=O)C2)CCOCC1 COCC1=CC=C(C(=O)NC2(CF)CN(C(=O)[C@@H1](C)CC(C)C)C2)C=C1 CCC1=NN(C)C(Cl)=C1C(=O)NC[C@@H1]2CC[C@H1]2NC(=O)C3=CC(C)=NC(OC)=C3 COC1=CC=CC(CNC(=O)[C@@H1](C2=NC(Cl)=CS2)N(C)[C@@H1]3CCCN(C)C3=O)=C1 CC(=O)N1CC(CC(=O)N(C)[C@@H1]2CC[C@H1](NC(=O)CS(=O)(=O)C3CC3)C2)C1 CO[C@@H1](CNC(=O)C1=NO[C@H1](C)C1)CC(=O)NCC2=CC(C)=CC(F)=C2 CC(C)[C@@H1](O)C(=O)N1[C@@H1](C)CC[C@H1]1C(=O)NCCS(=O)(=O)NC(C)(C)C COC1=C(NC(=O)[C@@H1](N)CC2=C(C)N=C3SC=CN23)C=CC(F)=C1Br CC[C@](C)(CO)CNC(=O)[C@H1]1C[C@@H1]1[C@@H1](C)NC(=O)C2=CN=N[NH1]2 CCN(C)CCC(=O)N1CC[C@@H1]2[C@H1](C1)CN2C(=O)C3=CC=C(OC)C=C3 CC(C)C=1C=COC=1C(=O)N2CC[C@@H1](O)[C@H1](NC(=O)C[C@@H1]3CCOC3(C)C)C2 C[C@@H1](CC1=CC=CC=N1)C(=O)N2[C@@H1]3C[C@H1](F)[C@H1](C3)[C@H1]2C(=O)NC[C@H1]4CCOC4 C#CCC[C@H1](NC(=O)[C@@H1]1[C@H1]2CCC[C@H1]21)C(=O)NC3=CC=C(O)C=C3OC CC1=CC(Cl)=CC(C)=C1C(=O)NCC2(CNC(=O)[C@H1]3CCO[C@H1]3C)CC(F)(F)C2 CC1=CC=C(OCC(=O)N2CC[C@@H1](N(C)C(=O)C3=CN(C)N=C3Cl)C2)C(C)=C1 C[C@H1](CC(F)F)C(=O)NCC[C@H1]1CCCN(C(=O)CC2=CC=C(Cl)N=C2F)C1 CC[C@H1](C)C(=O)N[C@H1]1[C@H1](C)N(C(=O)C2=CC=C(Cl)C(N)=C2)CC[C@H1]1C CCC1CN(CC(=O)NCC(C)(C)NC(=O)[C@@H1](O)CN2C=NC=N2)C1 CCCC[C@H1](CNC(=O)C1=CC=NC=C1Cl)NC(=O)C2=CN=C3N2CC[C@H1](C)C3 COC(=O)C1=CN=CC(CCNC(=O)N2CCC[C@@H1](OCC3CC3)C2)=C1 O=C(N[C@@H1]1CCC[C@@H1](C(=O)N2CCC[C@H1]3[C@H1](O)C[C@H1]32)CC1)[C@@H1]4C[C@H1]5CC[C@H1]4C5 CCC=1OC=CC=1C(=O)N2CCC(O)(CN=C3[NH1]C=NC=4C=C(Br)SC3=4)CC2 CCN(C(=O)C1=CC=C(Cl)C=C1I)[C@@H1]2CCN(C(=O)C=3[NH1]C=NC=3C)C2 CC(C)CSCC(=O)N[C@@H1]1[C@@H1](CNC(=O)C2=C[NH1]N=C2C(F)F)CCC13CCC3 CN(C)[C@@H1](CO)C(=O)N1CCN(C(=O)C2=NC=C(Cl)C=C2Cl)C[C@H1]1C3CCC3 CCCCCOCC(=O)N[C@@]12C[C@@H1]1CN(C(=O)[C@@H1]3CCC(=O)N(CC)C3)C2 CO[C@@]1(C(=O)N2CCC[C@H1](NC(=O)C3=CC=C(C4CC4)N=C3C)CC2)CCOC1 COCC1(C(=O)NCCCCCNC(=O)C2=CN=C(C(C)(C)C)O2)CC=CC1 COC(=O)C1=CC(C(=O)NC[C@@H1]2COC[C@H1]2NC(=O)C[C@@H1]3CCCC[C@H1]3O)=NO1 CC1=CC=CC(OCC(=O)NC[C@H1](C)CNC(=O)CN2N=C(C)C(C)=C2C)=C1 CC[C@@H1](CC(=O)NC(C)(C)CNC(=O)C1=CC2=NC(F)=CC=C2O1)C(C)C CNC(=O)CNC(=O)C=1OC(CNC(=O)[C@@H1]2CC[C@H1](C)O2)=NC=1C COC1=CC(C)=NC(N[C@H1]2CN(CC3=CC=CC=C3OCCBr)C[C@@H1]2C)=N1 COC1=CN=CC(C(=O)NC[C@@H1](C)NC(=O)C=2N=NN3C=2C(=O)NCC3)=C1C CC(C)/C=C/C(=O)NCCNC(=O)[C@H1](NC(=O)C[C@@H1](C)F)C1CCCC1 CC(C)OCCCC(=O)N1CC[C@H1](C)[C@H1](NC(=O)[C@]2(O)C[C@H1]3CC[C@H1]2C3)C1 CC=C(C)C(=O)N1CCN(C(=O)C=2OC=NC=2C(F)(F)F)C[C@@H1](O)C1 C[C@H1]1CN(C(=O)C2(C)CCC2)C[C@H1](C)C1NC(=O)CCCCF C[C@H1](C(=O)N1[C@@H1]2[C@H1]3C[C@H1]4[C@H1]2[C@@]4(C3)C1=O)N5C=C([C@@H1](O)C6=CC=CC=C6)N=N5 CCNC(=O)CCN[C@H1](C1=CC=C[NH1]1)C2=NC=CN2C CCCCC[C@H1](C)CC1=NC(C2=CC=CS2)=NN1C[C@H1]3CCOC3 C[C@H1](CC(=O)N1CCN(C(=O)CCC2(C)CC2)C[C@@H1]1CCO)N3C=CN=C3 C[C@@](O)(CC(=O)N1CC[C@H1](C(F)(F)F)[C@H1](N=C2C=C[NH1]C=C2[N+1](=O)[O-1])C1)C3CC3 CC=1[NH1]N=C(Cl)C=1C(=O)N2CC[C@@H1](C)[C@@H1](NC(=O)C3(C)CCC(C)(C)CC3)C2 COC(C)(C)CC(=O)N1CCC2(CC1)OC3(C)CC2(NC(=O)[C@H1]4C[C@H1]4F)C3 CC1=C[C@@H1](C(=O)NC2(CCC(=O)N[C@H1]3COC[C@@H1]3SC)CCC2)SC1 C=C[C@H1](CO)NC(=O)C[C@H1]1CCCCN1C(=O)C=2C=C(OC)N(C)N=2 O=C1N[C@@H1]2CC[C@H1]1CN(C(=O)[C@@H1]3CO[C@H1](CNC(=O)C4=CC=C[N+1]([O-1])=C4)C3)C2 CO[C@H1]1CN(C(=O)CN2CCOCC2)C[C@@H1]1C3=CN([C@@H1]4CCCCC[C@H1]4O)N=N3 O=C(/C=C/CN1CCOCC1)NNC(=O)[C@H1]2CCCN(C(=O)C3(C4CC4)CC3)C2 CN1CCC[C@@H1]1C(=O)N2C[C@@H1](CNC(=O)C34CC(CC(F)F)(C3)C4)OC(C)(C)C2 CN(CCCC(F)(F)F)C=1[NH1]C(=NCC=2C=COC=2C(F)(F)F)N=C3SC=CC=13 CS[C@H1](C)CC(=O)NC1(CNC(=O)[C@]2(C)CC=CCO2)CC3=CC=CC=C3C1 COC1=CC=CC(NC(=O)C2=CC(C3=CC(O)=CC=C3F)=CC=4[NH1]C=CC2=4)=C1Cl COC1=NC=C(C(=O)NCC[C@H1](O)CNC(=O)C2(F)CC2)C=C1C(F)(F)F C[C@@H1](NC(=NCC1=CC=C(Cl)C(F)=C1)N[C@H1]2C[C@@H1]2C)C3=CC=C(Br)C=C3 COCC=CC(=O)NCCN(CCCN(C)C)C(=O)C[C@H1]1CSCCS1 CC[C@H1](O)CC(=O)NC[C@H1]1CC(F)(F)CN1C(=O)C2=NC=C(N)C=C2C CCOCCN1C=C(C(=O)N2CCN(C(=O)C(C)=C3CC3)[C@@H1](CF)C2)C=N1 C#CC1=CC=C(OCC(=O)NC[C@H1]2CO[C@@H1](CNC(=O)CC=3C=COC=3)C2)C=C1 CCC[C@H1]1C[C@H1](C(=O)N2CCN(C3=NN(C)C=C3[N+1](=O)[O-1])C[C@](C)(F)C2)CCO1 COCCC(=O)N[C@@H1]1CCCC[C@@H1]1CNC(=O)C2=CSCS2 CO[C@@H1]1CN(C(=O)C=2C=C(Cl)N(C)N=2)C[C@@H1]1NC(=O)C3=CN=C(C)N=C3C4CC4 C#CCCCCC(=O)N1CC[C@]2(NC(=O)C=3SC(Cl)=C(Cl)C=3C)C[C@@H1]2C1 CCC1=CN=C(O)C(C(=O)NC23COC(CNC(=O)CCOC(C)C)(C2)C3)=C1 CC1=CC(S(=O)(=O)N2[C@H1]3C[C@H1]2CN(CC4=C(F)C=C(I)C=C4F)C3)=C(C)C=C1Cl C=C1CCC(C(=O)N[C@@H1]2C=C[C@H1](CC(=O)N3CC[C@@]3(C)C(C)C)C2)CC1 C=CC[C@]1(NC(=O)C2=CC(C(C)C)=NN2C)CCN(C(=O)[C@H1]3CCC[C@H1]3OC)C1 CC(C)(CC(=O)N1CC2(CC2)C[C@H1]1CNC(=O)C=3C=C4N(N=3)CCC4)CC(F)F CCC1=NN=CN1NC(=O)[C@@H1](C)NC(=O)CCN2C=CC=C2 CCC(=O)N1CC[C@H1](NC(=O)[C@H1]2CC(=O)CN2C(=O)C(C)(C)CSC)C1 CC=1OC=CC=1C(=O)N2CCN(C(=O)C3=CC(O)=C4C=COC4=C3)C[C@@H1]2C5CC5 COC1=CC=C(F)C=C1NC(=O)C[C@H1]2CCCN2CC3=CC4=CC(Cl)=CC=C4[NH1]3 CCCCCCCC(=O)N[C@H1](C(=O)NCC1=CC(CC)=CC=N1)C2CC2 CC1=CC(NC(=O)C[C@H1]2C[C@H1](F)CN2C(=O)[C@H1]3CCCS3)=CC=C1F CON=CC(=O)N1C[C@H1](O)C[C@H1]1C(=O)NC[C@@H1]2CN3CC[C@H1]2C3 CC(C)N(CCN(C)C(=O)C(F)(F)[C@H1](C)O)C(=O)[C@@H1](C)[C@H1](C)S(C)(=O)=O C=CCC[C@@H1](NC(=O)OC(C)(C)C)[C@@H1](C(=O)NCCC1CC1)N(C)C2CCC2 COC1=CN=CC(CN(C)C(=O)NC2CC(C3=CC=CC=C3Br)C2)=C1 COCCOCC=CC(=O)N[C@@H1](CCC1CC1)C(=O)N[C@H1](C)C2=C[NH1]C=CC2=O O=C(CCN1CC[C@H1](F)C1)NC[C@@H1]2C[C@]3(CCN(C(=O)C4=CC(Cl)=CS4)C3)CO2 CCC1=CC=C(C(=O)N[C@@H1]2CN(C(=O)C34CC(C#N)(C3)C4)C[C@H1]2C)C=C1Cl CC[C@H1](C(=O)NC(C)(C)CN(C)C(=O)C[C@@H1](C)N1C=CN=C1)N2C=CC=N2 O=C(C[C@@H1]1CN2CCC1CC2)N[C@H1]3C=CCN(C(=O)[C@]45C[C@H1]4CC6=C[NH1]N=C65)C3 C[C@@H1]1CCCC[C@@]1(CNC(=O)CC2CSC2)NC(=O)CN3CCCS3(=O)=O CN(C)[C@H1]1C[C@@H1](CNC(=O)C2=CC=C(C(=O)C3=CC=CC=C3)C=C2)C1 CO[C@@H1](CC(C)(C)C)C(=O)N(C)C/C=C/C(=O)N[C@@H1]1C[C@@]1(C)C(F)F O=C(NCC#CCCO)NC1=C(F)C=C(OCC(F)(F)F)C=C1[N+1](=O)[O-1] C#CCC[C@@H1](O)C(=O)N1C[C@H1]2CC[C@@H1]1[C@@H1]2NC(=O)CC3=CC=C(Cl)C=C3Cl CCCC(O)(CCC)CC(=O)NC[C@@H1]1C[C@@H1](NC(=O)C=2N=NN(C)C=2C)CCO1 O=S1(=O)CCC[C@@H1](N=C2[NH1]C(N3CCN4N=CC=C4C3)=NC5=C2CSC5)C1 O=C(NC1=CC=C(Cl)C(Br)=C1)C=2C=NC3=C(C=4N=C[NH1]N=4)C=NN3C=2 CN(C(=O)[C@H1]1CC=C[C@H1](N=[N+1]=[N-1])C1)C2CN(C(=O)C3=C(F)C=C(Cl)C=C3F)C2 CO[C@]1(C(=O)N2CC3(CC(NC(=O)C4=NC=NC=C4F)C3)C2)CCC[C@H1](C)C1 CC(C)(C)[C@@H1](NS(C)(=O)=O)C(=O)N[C@H1]1C[C@@H1](NC(=O)C2=CC=CC3=NC=CN23)C1 C#CCCO[C@@H1](C)C(=O)NC[C@]1(C)CCCN(C(=O)C=2C(C)=COC=2C3CC3)C1 C=CC[C@H1](C)C(=O)N1CC[C@@]2(CN(C(=O)CC3=CC=CC(C(F)F)=C3)CCO2)C1 CCCNC(=O)[C@H1](C)N(C)[C@@H1]1CCCN(C(=O)C2=CC=CC(C3=CN=CO3)=C2)C1 C[C@@H1](CN(C)C(=O)C1=CC=2SC=CC=2N1C)N(C)C(=O)C3=CC=C(CC4CC4)S3 C=CCCOCC(=O)N(C)[C@H1](C)CNC(=O)C=1SC(F)=CC=1Cl CN(CCCC1=CC=CC=N1)C(=O)C[C@H1]2CCN(C3=CC=C(F)C(F)=C3)C2 CCC1=NC([C@@H1](C)NS(=O)(=O)CC2=CC=CC=C2NC(C)=O)=N[NH1]1 C#C[C@]1(NC(=O)[C@@]23C[C@@H1]2CN(C(=O)[C@H1]4C[C@@H1]4Cl)C3)CCOC1 CCC(CC)C(=O)N[C@@H1](CNC(=O)CCNC(=O)C1CCC1)CC(C)C CC(C)NC(=O)C(=O)N1CCC[C@@H1](CCNC(=O)CC[C@@H1]2COC(C)(C)O2)CC1 C#CCO[C@@H1](C)C(=O)N[C@@H1]1CCC[C@H1]1NC(=O)C2=CC(=O)N3C=CC=CC3=N2 CC1=CC(C2=NN=C(C3=CC=C(CC(C)(C)C)C=C3)N2CO)=NN1C CCC1(C#CC(=O)NC2CCC(N(C)C(=O)CC[C@@H1]3CC3(Cl)Cl)CC2)CC1 C[C@@H1]1C[C@@H1](CNC2=CC=CC(F)=C2C#N)CN1C(=O)C3=COCCC3 CCC1=CC=C(C=2N=C([C@@H1]3CCN3C4CCCC4)N(CCCC(F)F)N=2)C=C1 CC(C)(CNC(=O)C1=CC2=CN=CC(Br)=C2S1)NC(=O)CC=3C=CSC=3 COC1=CC=C(CCC(=O)N2CC[C@@H1](O)[C@H1](C(=O)N=C3N=C[NH1]S3)C2)C=C1 CO[C@@]1(CNC(=O)NCC(C)(C)C2=NC=CC=C2C)CC[C@H1](C)C1 CC1=CC(C(=O)N[C@H1]2C[C@@](C)(NC(=O)CC3C(C)(C)C3(C)C)C2)=C(C)C=N1 CO[C@@H1]1CCC[C@@H1](CC(=O)N2CC(NC(=O)C3=CC(C(C)(F)F)=N[NH1]3)C2)C1 CC1=NC=NC(C)=C1OCC(=O)NCCOC(C)(C)CNC(=O)[C@H1]2C[C@H1](C)CO2 CC1=NOC(C)=C1[C@@H1](C)C(=O)N2CC[C@@H1]3CN(C(=O)CC=4C=COC=4C)CC[C@@H1]32 COC(=O)C1=CC(O)=CC(C(=O)N[C@H1](C)[C@H1]2CCN(C(=O)C34CC(C3)C4)C2)=C1 C=CCOCC(=O)N[C@@H1]1CC[C@H1]1CNC(=O)COC2=C(F)C(F)=CC(F)=C2F CCN(CCNC(=O)C(C)(C)C(F)F)C(=O)CCC1=CC=C(C(F)(F)F)C=C1 CC1=NC=CN=C1C(=O)N[C@@H1]2CCC[C@@H1]3CN(C(=O)CC4=NON=C4C)C[C@H1]32 CC1=CSC(C(=O)NC[C@H1]2CCCCCN2C(=O)C=CCOC3=CC=CC=C3)=C1 O=C(NC1CC2(CCN(C(=O)C3=CC=C(F)O3)C2)C1)[C@@H1]4C[C@@H1]4Br CCC[C@H1](C)C=1N=C(COCCC2=CC=CC=C2)N(C3=NC(Br)=NN3C)N=1 CCC=1N=CSC=1C(=O)NCC2=NC(C(=O)N[C@H1]3CCC[C@]3(C)CO)=CO2 CC[C@@](C)(CO)C(=O)N1CCC(N(C)C(=O)COC=2C=CSC=2Cl)CC1 CCO[C@H1](C)C1=NC(C)=C(C(=O)N[C@H1]2CN(C(=O)C=CC3CC3)CC4(CC4)C2)S1 CCC1=CN=C(C(=O)N[C@@H1]2CCC[C@@H1]2CNC(=O)CCN3C=CN=C3)N=C1 CCC1=CC(C)=C(C(=O)N2CCC3(CCN(C(=O)[C@@H1]4CC=C(C)CC4)CC3)CC2)O1 O=C(COCCC1=CC=CC=C1)N[C@@H1]2CO[C@@]3(CCCN(C(=O)C4CCC4)C3)C2 CCC=1N=C(C)[NH1]C=1C(=O)NC2=CC=CC(NC(=O)C=3N=NN(C)N=3)=C2 CC1=CC(O[C@@H1](C)C(=O)N[C@@H1](CNC(=O)CC(C)(C)C2CC2)C(C)C)=CC=C1Cl CCN(CC)C1=CC=C(C2=NC(C3=CC=CC(C(F)F)=C3)=NN2CCCO)C=C1 CCCSCCC(=O)N(CC)CCCNC(=O)C1=C(C)C=NN1C(C)C C[C@@H1](CCOC(=O)C1=CC([N+1](=O)[O-1])=CC(C(C)(C)C)=C1)C2CCCC2 CCCC[C@@H1](CNC(=O)[C@H1]1C[C@@](F)(CO)C1)NC(=O)C2=CC3=CC(C)=CC=C3S2 COC1=CC(C(=O)NC/C=C/CNC(=O)C2=CC=NN2C(F)F)=CC(F)=C1C#N C[C@@]12CN(C(=O)C=CC3=NC=C[NH1]3)C[C@]1(C)CN(C(=O)C4=CC=NO4)C2 COC[C@@H1](O)C(=O)N1C[C@@H1]2CC[C@]2(NC(=O)C3=CSC(C(N)=O)=N3)C1 COC1=CC=C(C(=O)NC[C@@]2(F)CCN(C(=O)[C@H1]3COCCO3)C2)C=C1 N#CCC(=O)N1C[C@@H1]2CCN(C(=O)C3=NO[C@@H1](C4=CC=CC=C4)C3)[C@@H1]2C1 CCC1=NC=CC=C1NC(=O)[C@H1](F)[C@H1]2CCN(C(=O)C[C@H1]3C[C@H1](SC)C3)C2 CC(C)(C)C[C@@H1]1C[C@H1]1C(=O)NC2([C@@H1]3CCN(C(=O)C4=COC=N4)C3)CC2 CCC1=NOC(CCC(=O)N[C@@H1](C)C2(O)CN(C(=O)[C@H1]3CCC[C@@H1]3O)C2)=N1 O=C(NC[C@]1(F)CCCN(CC2=CC=C(I)C=C2O)C1)C3=CC=C(C(F)(F)F)N=C3 CC(=O)C1(C(=O)N[C@H1]2CCC[C@H1]2CNC(=O)C(F)(F)C3=NC=CC=C3C)CC1 C#CC[C@@H1](NC(=O)C1=CC=C(CO)N=C1)C(=O)N(CC)C[C@H1]2CCOC2 CS[C@H1](C)CCC(=O)N1CC[C@H1](C)[C@@H1](CNC(=O)C[C@H1]2CCC3(CCC3)CO2)C1 CC[C@H1](CNC(=O)C1=CC(CO)=CC=C1OC)NC(=O)CCSC2=CC=CC=C2 C[C@H1](NC(=O)C1=CC(Cl)=CC=C1F)[C@@H1]2CN(C(=O)C3=NC(F)=CC=C3Cl)CCO2 CC(C)C(=O)N[C@@]12CCC[C@@H1]1N(C(=O)C3=CC=C4N=CSC4=C3)CC2 CC1=NSC=C1C(=O)N2CCN3CCC[C@H1]3C2 COC[C@](C)(OC)C(=O)N1CC[C@@H1](C(C)(C)NC(=O)C2=NOC(C)(C)C2)C1 O=C(C1=CN2C=NN=C2C=N1)N3CCN(C(=O)C(F)=CC4CC4)[C@H1]5C[C@@H1]53 CCN(C[C@@H1](C)NC(=O)C1CC(OC)(C(F)(F)F)C1)C(=O)CC2=CN(C)C=N2 COC1=CN=NC(C(=O)NCCNC(=O)[C@@H1]2N(C(=O)OC(C)(C)C)CC23CCC3)=C1 CSCCC(=O)N[C@H1]1CC[C@H1](CNC(=O)C2=CC(F)=CC([N+1](=O)[O-1])=C2)CC1 C=C1C[C@H1]1C(=O)N[C@H1]2CN(C(=O)C=3N=C(C)N(C=4N=C[NH1]N=4)N=3)C5(CCC5)C2 CCCC[C@H1](O)C(=O)N[C@@]1(CNC(=O)C2=CC=C(OC)N=N2)CCCC[C@@H1]1C CCOC1(COC(=O)[C@@H1]2CCC3=CC=CC=C3C2)CCC1 CCN(C)CC(=O)N1CC[C@@H1](C2(NC(=O)C3=CC(F)=C(F)C(F)=C3F)CC2)C1 CCN(C)C1=CC=C(CN2CCC[C@@H1](C(=O)NCC=3C=CSC=3)C2)C(C)=C1 NC(=O)CCC(=O)N1C[C@@H1]2CCC[C@H1](C1)N2C(=O)[C@H1]3C[C@@]34CCCOC4 CC1=CC(O)=C(C(=O)N2CC=C[C@H1]2CNC(=O)COCC3=CC=NC(O)=C3)N=N1 CCC(F)(F)CC(=O)N1CCC[C@]1(CNC(=O)CC2=CON=C2C)COC O=C(N[C@@H1]1C[C@@H1]2C[C@H1]1N(C(=O)C=3[NH1]C=C4C=3CCC4)C2)[C@H1]5CCC6=CN=NN6C5 CCC1=NC(OC)=CC=C1NC(=O)N2CC(N(C)CCOC)C2 CC#CCCCC(=O)N[C@@H1]1CN(C(=O)C2=CC(OC)=CS2)[C@H1]3C[C@@H1]13 COC1=CC(CO)=CC=C1C(=O)N2C[C@@H1](F)C[C@H1]2CNC(=O)CCS(C)(=O)=O CN(CCN1C=CC=N1)C(=O)CCC2(NC(=O)CCCCCN=[N+1]=[N-1])CCCC2 CC(C)O[C@]1(C(=O)N2CC[C@](O)(CNC(=O)CC3=CN=C[NH1]3)C2)CCOC1 CN=C1N=C(N2CCO[C@H1](C(C)C)C2)[NH1]C(N3CC[C@@H1](C(F)F)C3)=N1 COCC[C@H1](OC)C(=O)N1CC([C@H1](O)C(=O)NC[C@H1](F)C2=CC=CC=C2)C1 CCCN1N=NN=C1[C@@H1](NCC2=CC(C)=NN2C)C3=CC=C(C4CC4)O3 CC(=CC1=CC=CO1)C(=O)N2C[C@H1](CNC(=O)[C@H1]3CC(=O)[C@@H1]3C)C(F)(F)C2 O=C(NCCS(=O)(=O)C1=CC=C(F)C=C1)[C@H1]2NOCCOC23CCC3 CC1=CC(C(=O)NCC[C@@H1](C)NC(=O)C=CC2=CC=C(Cl)N=C2)=NN1C(F)F C=CCN1C=C(C(=O)N[C@@H1]2CCC[C@H1]2CC(=O)N(C)[C@@H1](CO)CC3CC3)N=N1 O=C(N[C@H1](CN1C=NC=N1)C(=O)N2O[C@H1]3C=C[C@H1]2CC3)C=4C=CN(CCF)N=4 CC1=CC=CC=C1CN=C(NC2CCN(C3=NC=CC=N3)CC2)NC4CC4 COC[C@@H1]1CCN(C(=O)[C@H1]2CCCCN2C(=O)C3=CC=CC4=C[NH1]N=C34)C1 C[C@H1]1CN(C(=O)C[C@H1]2CCCC(=O)N2)C[C@H1]1NC(=O)[C@H1]3CCCN4C=NN=C43 CC(C)(C)[S@](=O)(=NC(=O)[C@@H1]1CC12CC(F)(F)C2)[C@@H1]3CCNC3 CC1=NN(C)N=C1C(=O)N[C@H1]2CN(C(=O)CN(C)C3=CC=CC=C3)CC2(C)C C[C@@H1]1C[C@@H1](CNC(=O)C(C)(C)CS(C)(=O)=O)CCN1C(=O)CC2=CC=C(F)C=N2 CCO[C@H1]1CCCN(C(=O)[C@H1]2CN(C(=O)C3=CC=CC=C3CC)CCC2(C)C)C1 CC[C@@H1](C)[C@H1](C)CN=C1[NH1]C(=NCCN2CCCCC2=O)C3=C(F)C=CC=C3[NH1]1 CCOC(=O)NCCCC(=O)NCC12CC(CNC(=O)C[C@H1]3OCC[C@@H1]3C)(C1)C2 CCN(C(=O)C=1N=COC=1Br)[C@@H1]2CCN(C(=O)[C@H1]3CCCN3C)C2 O=C(NCC1(NC(=O)C2=CC(F)=C(F)C=C2O)CC1)C3=CC=C(O)C=C3O CCC1=CON=C1C(=O)N2C[C@H1]3C[C@@H1](C(=O)N(C)C[C@H1](C)C(=O)OC)C[C@H1]3C2 CCC[C@@H1](CNC(=O)C1=C[NH1]C(C(N)=O)=C1)C(=O)NCC[C@H1]2C[C@H1](F)C2 CC1=CC=NC(C[C@H1](N)C(=O)N(C)CCC=2C=NN(C)C=2)=C1 CCCC=CC(=O)N1C[C@H1](NC(=O)[C@@H1](OC)C2CCCC2)CC13CCC3 O=C(C1=CC=CC=N1)N2CCN(C(=O)C3=CC=C(OC4=CC=CC=N4)C=C3)CC2 C=C[C@](C)(O)C(=O)N[C@@H1]1C[C@@H1]2CN(C(=O)C=3C=C(C)N(NC(N)=O)C=3C)C[C@@H1]21 C=CC[C@](C)(CC)C(=O)N(C)CC1(O)CCN(C(=O)C[C@@H1](CC)C(C)(C)C)CC1 CC=1N=C[NH1]C=1C(=O)NC[C@H1]2[C@H1](C3CC3)CCN2C(=O)C4CSC4 COC(=O)C1=C(C)[NH1]C(C(=O)[C@@H1](C#N)C2=NC(O)=C3C=NN(C)C3=N2)=C1C CN1CCOC[C@@H1]1C(=O)NCC2=CC=CC(NC(=O)C3=CC=NN=C3)=C2 O=C([C@@H1]1C[C@H1](O)CN1C(=O)CC=2C=CSC=2)N3CCN4C(=O)OC[C@H1]4C3 CC[C@H1]1C[C@H1]1C(=O)NC[C@H1](C2CC2)N(C)C(=O)C3=CC=C(CNC(C)=O)O3 COCCC[C@@H1](C)C(=O)NCC[C@]1(O)CCN(C(=O)CCCCCCC(C)C)C1 COC1(C(=O)NCCCCNC(=O)C=CC=2C=C[NH1]C=2)CCCC1 C=CC[C@]1(NC(=O)C#C[C@H1]2CCOC2)CCCN(C(=O)CNC(=O)CC)C1 CO[C@H1]1CN[C@H1](CNC(=O)N2CCN(S(=O)(=O)C3=CC=C(C)C(C)=C3)CC2)C1 CC1=NN=CC=C1C(=O)NC[C@@H1]2CC[C@@H1]3CN(C(=O)C=4C=CN(CCF)N=4)C[C@H1]32 COC(=O)C1=CC=C(C(=O)NCC2[C@H1]CCN(C(=O)C3CC(C)C3)[C@@H1]2C)N=C1 CO[C@@H1]1C[C@H1](C(=O)O)N(CC(=O)CC2=COC=N2)C1 N#CC1=NC=C(N[C@@H1]2[C@@H1](O)[C@H1]3CCO[C@H1]32)N=C1Cl C[C@H1]1C[C@@H1](C)CCN(C(=O)[C@H1]2CCCC[C@H1]2NC(=O)C3=CC4=NC=CC=C4[NH1]3)C1 CN(CC1(CNC(=O)[C@@]2(Cl)CC2(C)C)CC1)C(=O)[C@@H1]3CC[C@@H1]3C=4N=C[NH1]N=4 COC1=NC=NC=2SC(NC(=O)C34CC5C[C@](C)(C3)C[C@@](C)(C5)C4=O)=NC1=2 C[C@H1](CN(C)C(=O)CS(=O)(=O)C1CC1)NC(=O)CNC(=O)C2=CC=CC=C2 CC(C)OC1=C(N)C=CC=C1C(=O)N2CC3(CCN(C(=O)C[C@H1](C)N(C)C)C3)C2 O=C(C[C@H1]1CCCC(F)(F)C1)NCCCNC(=O)C2=C[NH1]N=C2N3C=NN=N3 CC1=NOC=C1[C@@H1](NCCOCC2CCC2)C3=NN=NN3CCCC4CC4 CCN=NN(CC(=O)N[C@@]1(CO)CCCN(C(=O)CC23CCC(CC2)C3(C)C)C1)N C[C@@H1]1CCN(C(=O)C(C)(C)S(C)(=O)=O)C[C@@H1]1NC(=O)CCCNC(=O)C(C)(C)C CN=C1[NH1]C(=N[C@H1](CF)C2=CC=CC=C2F)[NH1]C(=NCCC3=CC=C(C)N=C3)[NH1]1 C=CCC(=O)N1CC[C@H1]1C(=O)NCCS(N)(=O)=O CC=1C=C(C(=O)N2CCO[C@@H1](CN(C)C(=O)C=CC3=CN=CN3C)C2)SC=1C COCC(=O)N[C@@H1]1CCC[C@@H1](NC(=O)CC2=CN=CC=C2Cl)CC1 COCCCS(=O)(=O)NCC(=O)N1C[C@@H1](O)[C@@H1](CNC(=O)C=2[NH1]C(C)=NC=2C)C1 CO[C@H1]1C[C@@H1](C(=O)N(C)[C@@H1]2CCN(C(=O)C(F)(F)C3=NC=C(Cl)N3C)CC24CC4)C1 CCO[C@H1](CC)C(=O)N1CC[C@@H1](N(C)C2=NC(C)=NC=3SC(CC)=CC2=3)C1 CCC(=O)N1CC[C@H1](C(=O)NCCC[C@H1]2CCCN2C(=O)[C@H1](C)S(C)(=O)=O)C1 O=C(N[C@@H1]1CCCN(C(=O)C2=CN=NC=C2O)C1)C=3C=NN4C=CN=CC=34 CN(C)C[C@H1](O)CC(=O)NC[C@H1](NC(=O)[C@H1]1COC(=O)O1)C2=CC=CC=C2F CCCC[C@@H1](CNC(=O)C=CC1=CC=CC(CO)=C1)NC(=O)C=CC=2C=CSC=2 CC1=CC[C@@H1](C(=O)NC2=N[NH1]C(C3=CC=CC(OCCN)=C3)=N2)CC1 NC1=CC(C(F)(F)F)=CN=C1C(=O)OCC(=O)N2CCN(CC(F)F)CC2 CN1C[C@H1]2[C@@H1](C1)[C@@H1]2C(=O)N3CCCC[C@H1](NC(=O)C4CCC5(CCCO5)CC4)C3 O=C(N[C@@H1]1[C@@H1]2CN(CC3=CC(F)=C(C)C(F)=C3F)C[C@@H1]21)C4=CC=CO4 CO[C@H1](CC(C)C)C(=O)N[C@H1]1CC[C@@H1](C(=O)N[C@H1]2CCC3=CC=CN=C32)C1 COC(=O)[C@@H1]1CCN1C(=O)[C@H1](CNC(=O)C2=CC=CC(Cl)=C2)C(C)(C)C C[C@@H1](NC(=O)[C@H1]1CS(=O)(=O)CC1C2CN(C(=O)CCC#N)CCO2)C(N)=O COC1=CC=CC([C@H1](C)CC(=O)NCCN(C)C(=O)[C@@H1]2CC=CC[C@H1]2C)=C1 CO[C@H1](CNC(=O)CCCC1=CN=CS1)CNC(=O)C[C@H1]2C(=O)N(C)N=C2C CC1=NOC=C1CC(=O)NCC23CCC(CC2)CN3C(=O)[C@@H1]4C[C@H1](C)OC4=O COC1=CC=CC=C1OCCC(=O)NCC2(NC(=O)CC3CC(=O)C3)CCC2 CN(CCOCCNC(=O)[C@@H1]1CC(=O)N1)C(=O)C2[C@H1]3CCC[C@H1]23 C=C1CC(COC(=O)C2=CN=CC(C3=CC=CC=N3)=C2)C1 COC(=O)[C@@]1(C)C[C@H1](OC)CN1C(=O)N[C@@]2(C3=CC=CC=C3)C[C@H1](O)C2 O=C(N[C@H1](CO)CNC(=O)[C@H1]1CCCN1C2=CN=CC=N2)C3CC=CC3 C[C@@H1](NC(=O)C1=NC=C(Cl)S1)[C@@H1](CO)NC(=O)C2=N[NH1]C=C2C3CCC3 C=CC[C@@H1](CC)C(=O)NCC1=CN(CC(=O)NOCCCC(F)(F)F)N=N1 C=CCOCCN=C1[NH1]C(N(C)CCC(C)(C)C)=NC(=N)[NH1]1 CO[C@@H1]1C[C@H1](CC(=O)N2CCOC[C@@H1](NC(=O)C3(CCO)CC3)C2)C1(C)C CCN(C(=O)N[C@@H1](C)C1=CC=C(OC)C(Cl)=C1)[C@H1](C)CO C[C@@H1]CCCCNC(=O)CC1(NCC2=CC=C(C#N)C(Cl)=C2)CC=CC=CC1 C#C[C@H1](CNC(=O)[C@@H1](CCCC)NC(=O)CC[C@@H1](C)CN(C)C)CC1CC1 CC1=NN(CC(=O)N2C(CNC(=O)[C@@H1]3CC3(C)C)CCC(C)(C)CC2)C(C)=C1Cl CCC1=CC(N)=C(C(=O)NCCCCN(C)C(=O)[C@H1]2C[C@@]2(C)C(C)C)C(OC)=C1 C[C@H1](CNC(=O)C1=NC=NC2=C1CCC2)NC(=O)C3=CC=C(Cl)C=C3O C=CCC[C@@H1](NC(=O)CS(=O)(=O)CC)C(=O)N(C)CC1=C[NH1]N=C1C CC1=CC(C(=O)N2CCC([C@H1]3CCCCN3C(=O)C[C@@H1]4CCCO4)CC2)=NO1 CC1=CC=CC=C1[C@@H1](C)C(=O)N[C@@H1](C)CC2CN(C(=O)C3=CC=CC(C)=C3O)C2 CN1C(Br)=CN=C1C(F)(F)C(=O)N2CC[C@]3(C)[C@@H1](C2)C3(F)F CC[C@@H1](OC)C(=O)NC1CC2(CC(NC(=O)C3=COC(C)=N3)C2)C1 CN1C=CC=C1C2=CN(C3CCC(C(=O)N[C@@H1](CO)CCF)CC3)N=N2 CCNC(=O)C(=O)NCC1CC(NC(=O)[C@@]2(C)CCC(=O)N2)C1 C[C@H1]1[C@H1](C)N(C(=O)C=2C=C(CCNC(=O)CN3C=CN=C3)ON=2)CCN1C C#CCC(CC#C)C(=O)N1C[C@@H1]2CC[C@]2(CNC(=O)C3=CN=CC(F)=C3)C1 O=C(N[C@@H1]1CCC[C@H1]1NC(=O)[C@H1]2CC23CCCC3)C=4C=C(C5CCC5)[NH1]N=4 CC[C@@H1]1C2=CC=CC=C2CCN1CC3=CC=CC(F)=C3I CC1=NC(C=CC(=O)N[C@H1]2CC[C@@H1](NC(=O)CN3CCC[C@H1]3C)C2)=CS1 C[C@@H1](CNC(=O)C1=CC=C([N+1](=O)[O-1])C=C1Br)NC(=O)C2CC3(CSC3)C2 C=C=CCC(=O)N[C@@H1](CC=C)CNC(=O)[C@@](C)(F)C(=O)OC CO[C@@H1](C)[C@@H1](O)C(=O)N1CC(NC(=O)C(F)(F)C2=CC=C(F)C=C2C)C1 CCCCCCN1N=NN=C1[C@@H1](NCC2(OC)CCCCCC2)C(C)(C)C(C)C C[C@@H1]1CCN(C(=O)C(=O)N2CC3=CC=CC=C3C4CC2C4)CC1(C)C CCCNC(=O)CN(C)C(=O)C[C@@H1](NC(=O)C[C@@H1]1CCCN(C)C1)[C@@H1](C)CC CC[C@@H1](CNC(=O)CN1C=CC(C(F)(F)F)=N1)NC(=O)C=2SC=C(C)C=2Cl CCC[C@H1](O)CC(=O)N1CCN(C(=O)C2=CC=NC(N3C=CC=C3)=C2)C[C@H1](O)C1 CC1=CC(C(=O)N2CC[C@@H1](NC(=O)C[C@@H1]3CC(C)(C)CO3)C2(C)C)=NC=C1Cl O=C(N[C@H1]1[C@@H1]2CN(C(=O)C3CCS(=O)CC3)C[C@@H1]21)[C@H1]4C[C@@H1]5CC[C@H1](C4)[C@@H1]5O CC[C@H1](CC(=O)N(C)CCNC(=O)C1=CC=NC(C(N)=O)=C1)OC CC1=CN=C(CCC(=O)NC[C@@H1](CNC(=O)C[C@@H1]2CCCC[C@H1]2O)S(C)(=O)=O)[NH1]1 CC1=CC(C(=O)N(C)C2CC(NC(=O)CC=3C=C(Cl)N(C)N=3)C2)=CC=C1O CN(CCCOCCNC(=O)C=1C=C2N(N=1)CCO2)C(=O)[C@@H1]3CC=CCO3 C#CC[C@@H1](C(=O)NC1CC(CNC(=O)C2=CC=NC(N3C=CN=C3)=C2)C1)C4CC4 C[C@@H1]1CC[C@@H1](NS(=O)(=O)C2=CC=C(N(C)CCCCO)C(C#N)=C2)C1 C[C@H1]1CN(C(=O)CC(F)(F)Cl)CC[C@@H1]1CNC(=O)CN2C=NC([N+1](=O)[O-1])=N2 CO[C@@H1](CNC(=O)C1(F)CC=CC1)C(=O)NC[C@@H1](CO)C2CCC2 CCN1C[C@H1]2C[C@@H1]1CN2[C@H1](C(=O)NC[C@H1]3CCOC3)C=4SC=NC=4Cl C=C[C@@H1](NC(=O)C[C@H1](NC(=O)C1(COCC)CC1)C(F)(F)F)C2CC2 COC(=O)[C@@H1]1C[C@H1]1CCN[C@@H1](C2=NN=NN2CCCF)C3=C(OC)N=CN=C3OC COCC1(C(=O)N2CCN(C(=O)C3(N(C)C)CCC3)[C@@H1](CC(C)(C)C)C2)CCC1 CO[C@H1](C)C1CN(C(=O)[C@@H1](C2CC2)N(C)C(=O)CCCCN(C)C)C1 CC=1[NH1]C(C#N)=CC=1C(=O)N(C)C[C@H1](C)NC(=O)C2=NSC3=CC=CC=C23 CC1=CC=C(C(=O)N[C@@H1]2CC[C@H1]3C[C@H1]2CN3C(=O)[C@@H1](O)C4CC(F)(F)C4)O1 CSC1=CC(C(=O)NC2CC(CNC(=O)C3=CC(C)=C(C)S3)C2)=NN1C C=C(C)C[C@H1](OC)C(=O)NC[C@H1]1CO[C@@H1](C(F)(F)F)CN1C(=O)OC(C)(C)C CCC1=CC=C(CNC(=O)CN(C)C(=O)CC[C@@H1](C)CC(=O)OC)C=C1 CN1CCC[C@@H1]1CNC(=O)CC[C@@H1]2CCCN(C(=O)C=CCO)C2 CC1=CC(C(=O)N2CC[C@H1](N(C)C(=O)CN=C3C=CC(C#N)=C[NH1]3)C2)=C(C)C=N1 CC1=NS(=O)(=O)NC(C)=C1CC(=O)N(C)[C@@H1]2CCCN(C(=O)C3CC(F)(F)C3)C2 CN(C)C1=CC=C2N=C(CC(=O)N3CCC(NC(=O)C4=COCCC4)CC3)SC2=C1 CCOC=CC1=C(NC(=O)C=2N=C(C3=CC=NN3COC)SC=2C4=CC=CC=C4)C=C1 N#CC1=CC(C(=O)N2CCC[C@@]3(NC(=O)CSCCC(F)(F)F)CCC[C@H1]23)=NO1 COCO[C@@H1](C)C(=O)N1CC[C@H1]2CCN(C(=O)CCNC(=O)C=CCl)C[C@H1]2C1 O=C(C[C@H1]1CCOC1)NC[C@@H1](CC(=O)N2CCN3CCC[C@H1]3C2)C4CCC4 CCOC1=CC=C([C@@H1](C(=O)NC2=CC=CC=C2Cl)N3CC[S@](=O)C[C@@H1](C)C3)N=C1 CCC(C)(C)C(=O)N[C@@H1]1CN(C(=O)[C@@H1](C)CC(F)(F)F)C2(CCOCC2)C1 CN1C=C(C=CC(=O)NC[C@@](C)(CO)NC(=O)CC23CCCN2CCC3)C=N1 CO[C@@H1](CNC(=O)C[C@@]1(C)CCN(C(=O)C2(C)CSC2)C1)C(C)(C)C CCO[C@H1](C)CCC(=O)NCCCN1CC[C@@H1](NC(=O)C[C@H1]2C[C@H1](SC)C2)C1 CC(C)C[C@@H1]1CCCN(C(=O)C(C)(C)CNC(=O)C2=CC=C(F)C=C2F)C1 COC(OC)C(=O)NC[C@H1]1C[C@@H1](NC(=O)C2=CC=C3C(=C2)NC(=O)CS3)C1 N#CC1=CC=CC(/C=C/C(=O)N2CC[C@@]3(CCN(C(=O)C4=CSC=C4Br)C3)C2)=C1 C[C@H1](CCNC(=O)[C@]1(C)CCN2C(C)=NN=C21)NC(=O)C=CC3=CC=CN=C3 CCCCC(F)(F)C(=O)N[C@@H1]1CN(C(=O)C2=CC(N)=C(F)C=C2C)CC[C@H1]1O CCC1(C(=O)NCC2=COC=N2)CN(C(=O)C=3C=C(C(C)=O)ON=3)C1 CC[C@H1](CC(=O)N(CCCNC(=O)C1CN(C(=O)NC)C1)C2CCCC2)C3CC3 COCCC1(C(=O)NCC[C@@H1](C)C(F)F)CCN(C(=O)[C@H1]2CCC3(CC3)C2)CC1 C#C[C@]1(O)CCCN([C@H1](C(=O)NC[C@@H1]2CCOC2)C3=CC=C(OC)C(F)=C3)C1 CCCN1N=CC=C1C(=O)N[C@@]23CCC[C@@H1]2N(C(=O)C4=CN=C(C(N)=O)S4)CC3 CCC1=CC=C(C(=O)C(=O)N2CC[C@@H1](CNC(=O)C=3C=CN(CC)N=3)C2(C)C)S1 COC(=O)[C@@H1](CCF)NC(=O)[C@@H1](CC1CC1)NC(=O)C2=CC(C)=C[NH1]2 CC1=CC(C(=O)N[C@H1]2CC23CCN(C(=O)C=CCF)CC3)=C(C)N1CC4CC4 C[C@@]1(C(=O)N2C[C@H1](NC(=O)[C@]34C[C@H1]3CNC4=O)C5(CCC5)C2)CNC(=O)N1 CC(C)(C)OC(=O)C([C@@H1](N[C@H1]1CC12CCCC2)C3=NN=NN3CSC4=CC=CC=C4)CC C[C@H1]1CC[C@@H1](CC(=O)NC(C)(C)CCNC(=O)C2=CC=CC(C(C)(F)F)=C2)C1 CC1=CC=C2C(=C1)C[C@@H1](C(=O)N3C[C@@H1]4C[C@H1](C3)CN4C(=O)C56CC(C5)C6)O2 CN(CCCNC(=O)[C@H1]1CCCC1(C)C)C(=O)C2=CN=CC=N2 CC1=C(C(=O)NCC2(NC(=O)[C@H1]3CCC34CCC4)CC2)CN5N=NN=C5N1C COC1=CC=NC=C1C(=O)N2CC[C@H1](C)[C@H1](NC(=O)C=3C=C(Cl)N(C)N=3)C2 C#CCCCC(=O)N1C[C@@H1](O)[C@H1](NC(=O)C2=C[NH1]C3=CC(F)=CC=C23)C1 CNC(=O)CC1=CC=C(C(=O)N[C@@]2(C)CCN(C(=O)CC[C@@H1]3C[C@H1]3C)C2)C=C1 CC[C@H1](C)C(=O)N[C@@H1]1C[C@H1](C)N(C(=O)C2=CC=C3C(=C2)CCN3S(C)(=O)=O)C1 CNS(=O)(=O)CC(=O)N[C@@H1](C)[C@@H1]1CCCN1C(=O)[C@@H1]2CCC(=O)N2 C#C[C@@H1](NC(=O)[C@H1]1CCN(C(=O)CCCC(=O)N(C)C)CCO1)C2CCOCC2 CCCCC(=O)C(=O)NC[C@H1]1CC[C@H1](C)CN1C(=O)C2=CN=C(C3CC3)N=C2 CCN(C(=O)C=1C=C(Br)N(C)N=1)[C@H1]2CCN(C(=O)[C@@H1]3C[C@@H1]4CC[C@H1]3O4)C2 NC1=CC(C(=O)NC2[C@H1]3COCC[C@@]3(NC(=O)[C@@H1](O)C(F)(F)F)C2)=NC=C1Cl C#CCN1C=NN=C1C(=O)N(C)C[C@@H1]2CCCN2C(=O)C3=CC=NC=C3O C=C(Cl)CCC(=O)N1CCOC[C@@](F)(CNC(=O)C[C@H1]2CCCN2C)C1 CC1=CC(C(=O)NCC2=CC(C(=O)N3CCCOC(C)(C)C3)=CS2)=CN1C CCN1N=NN=C1[C@]2(NCCCCC=3C=N[NH1]C=3)CCS[C@@H1]2C COC[C@]1(CNC(=O)C2CN(C(C)C)C2)CCCN1C(=O)C3=CC=C(O)N=C3Cl CC1=NOC(C(=O)N2CC[C@H1](NC(=O)C3=CC=NC=C3C(F)(F)F)C[C@@H1]2C)=N1 CC(C)CC1(C(=O)N[C@@H1]2CC[C@@H1]2NC(=O)C3=CN(C4CCC4)N=N3)CCCC1 CCOCCC(=O)N1CCN(C(=O)C2=CC=CC3=C2OCO3)C[C@H1]1C4CCCC4 C=CCCN=C(NCCC1=CN=C2N1CCCC2)N(C)CC=3C=CN(CC)C=3C C=CCC1(NC(=O)CC=2C=C(Cl)SC=2Cl)CN(C(=O)[C@H1](C)OCCC)C1 CC(=CC(=O)N1C[C@@H1](C)[C@@H1](NC(=O)C2=NOC=C2Cl)C1)C3=CC=CO3 CC=1N=COC=1C(=O)N2CC[C@@H1]3C[C@@]32C(=O)NC[C@H1]4CC4(F)F CC1CCC(O)(CNC(=O)C2=CC(CNC(=O)CN3CCOC3=O)=NN2C)CC1 CCC[C@H1](CC(=O)N[C@H1]1CC[C@H1](O)CC1)NC(=O)C2=CC=C(C)O2 C=C[C@](C)(CC)C(=O)N(C)CCN(C)C(=O)CC[C@@H1]1CC1(F)F CC[C@H1](C)C(=O)N[C@@H1]1CCC[C@@H1]2CN(C(=O)CCOCC(F)F)C[C@@H1]21 CCOCCO[C@@H1](C)C(=O)N[C@@H1]1CC[C@@H1]1CNC(=O)C=2C=C3C=CC(C)=CN3C=2 C=CCCO[C@H1](C)C(=O)N1C[C@@]2(C[C@@H1]1CNC(=O)C=3C=N[NH1]C=3)CC2(F)F CCC(CC)[C@H1](C)C(=O)N[C@@H1]1CCC[C@@H1](NC(=O)C2(C)CC3=CC=CC=C3C2)C1 C=CC[C@]1(C(=O)N[C@H1](CCC(=O)NC2(C)CS(=O)(=O)C2)C(C)C)CCOC1 CC[C@H1](CCC(=O)N(C)CC=1C=CSC=1C)NC(=O)C[C@@H1](C)N(C)C CC[C@@H1](C)N1N=NN=C1[C@@H1](NCC2=NOC=C2Br)C3=CN=CO3 NC(=O)CCC1=CC=C(CN2CCC(O)(C(=O)NCC3CCCCC3)CC2)C=C1 O=C(CC=1C=CON=1)N[C@@]23CCC[C@H1]2CN(C(=O)C4=CCS(=O)(=O)C4)C3 COCC1(NC(=O)C=C(C)C(C)C)CN(C(=O)C2CC(F)(F)C2)C1 CCOC(=O)N1CCC(C(=O)N[C@H1]2C[C@@H1](CNC(=O)[C@H1]3CC[C@@H1](C)C3)C2)CC1 C[C@H1](CNC(=O)[C@]12C[C@H1]1COC2(C)C)NC(=O)CNC(=O)C3=CC(Cl)=CC=N3 CN(C[C@@H1]1CCOC1)C2=NC(N3CCC(CS(N)(=O)=O)CC3)=NC4=C2CCC4 CC[C@@H1](C)N(C)C(=O)C1CC2(CC(NC(=O)C3=CC(C)=NN3CC)C2)C1 CCCN(C(=O)C=NOC)[C@@H1]1CCN(C(=O)C2([C@@H1]3CCCCO3)CCC2)C1 COC1=NC(Cl)=C(C(=O)N[C@@H1]2[C@H1]3C[C@@H1]2N(C(=O)[C@@H1]4C[C@H1]5COCCN5C4)C3)S1 CC=1SC=CC=1C(=O)N2CCN(C(=O)[C@@H1](C)OC3=CC=C(O)C=C3)[C@H1]4COC[C@H1]42 CC(C)OC1=CC=C(CNC2=CC(N3CC[C@@]4(C[C@H1]5CC[C@H1]4C5)C3)=NC=N2)C=C1 O=C(NC1=CC(O)=C(Cl)C=C1F)C2=CC=C(N3CCN[C@@H1]4CS(=O)(=O)C[C@@H1]43)C=C2 CC[C@@H1](COC)C(=O)N1CC2(CC2)C[C@H1]1C(=O)NC[C@@H1](CC)C(C)(F)F CCCCCC[C@H1](O)CCC(=O)N1C[C@H1](CNC(=O)C[C@@H1](O)CCC)[C@@H1](C)C1 CC(C)C1=CC(C(=O)N[C@H1](C(=O)N2C[C@H1](C)O[C@H1](C)C2)[C@@H1]3CC=CCC3)=N[NH1]1 COC(=O)CCC(=O)N(C)C[C@@H1]1CCCN(C(=O)[C@@H1]2C[C@H1]3CC[C@@H1]2CC3(F)F)C1 O=C(NC[C@H1](CO)C1CC1)N2CCC3(C2)OC4=CC=CC=C4O3 C[C@H1](C(=O)NCCC[C@@H1](O)C(=O)N=C1C=CN(C)[NH1]1)C2=CC=CC=C2 CC=1C=CSC=1C=CC(=O)N(C)C[C@@H1](C)CNC(=O)C(C)(C)CS(N)(=O)=O CCN1C=CN=C1CN(C)C(=O)[C@H1]2CN(C(=O)C[C@H1](C)COC)C3(CCC3)C2 CC1=CC(C(=O)NCC[C@@H1]2CCN(C(=O)CN3[C@H1](C)CC[C@H1]3C)C2)=CN1C O=C1N[C@H1](C(=O)N(CCNC(=O)C=2[NH1]N=C3N=CC=CC=23)C4CC4)CO1 CC1=CC=C(COCC(=O)NCCCNC(=O)[C@@H1](C)C2CC2)C=C1 C[C@H1](CN=C1[NH1]C2=C(C(=NC3CC4(CCCC4)C3)[NH1]1)CSC2)N(C)C CC=1N=COC=1C(=O)N2CC[C@]3(C[C@H1]3C(=O)N4CCCC[C@H1](S(C)(=O)=O)C4)C2 COC(=O)C1=CN=CN1CC(=O)O[C@H1]2CCOC3=CC=C(Cl)C=C32 C[C@H1](C(=O)NC1=CN=CN=C1Cl)C2CCN(CC3=NC=C(Cl)C=C3F)CC2 C[C@@H1]1CN(C(=O)C2=CC=C(NC=O)C=C2)CCN1C3=CC=NC=C3 CS[C@H1](C)C(=O)N[C@@H1]1C[C@@H1]2C[C@@H1](NC(=O)C3(C=4C=CSC=4)CC3)C[C@@H1]21 CC(C)=C(C)C(=O)NC[C@@H1]1CCC[C@@H1]2CN(C(=O)C3=NO[C@@H1](C)C3)C[C@H1]21 C#C[C@]1(O)C[C@@H1](C(=O)NC[C@@](C)(CC)NC(=O)[C@H1]2CCC(=O)N2C)C1 CCC1=CC=CC=C1CN2CCOC[C@H1]2CC(=O)NCCCN3CCCC3 CC(C)N1C=NC(C(=O)N[C@](C)(C(=O)N2CC([S@@](C)(=N)=O)C2)C3CCC3)=C1 CO[C@@H1](CC(C)C)C(=O)NC1=CC=CC(NC(=O)[C@@H1]2CCC2(C)C)=C1 C[C@@H1](CNC(=O)[C@@H1]1CCN2C(=NN=C2C(F)(F)F)C1)NC(=O)C(C)(C)CC#N CC[C@](C)(COC)C(=O)N1CC[C@@H1]2C[C@@]21C(=O)N[C@H1]3CCCC[C@@H1]3C#N C[C@H1](CN(C)C(=O)C=1SC(C#N)=CC=1Cl)NC(=O)C2=CC=C(N3CCCC3)N=N2 CCO[C@H1](C)C(=O)NCCN(C(=O)COCC(F)(F)F)C1CCCCCC1 C[C@@H1](CNC(=O)C1CCC2(CC1)CC(O)C2)NC(=O)C=CC3=CC=CS3 CN(CCNC(=O)C1=CC2=C(N1C)CCOC2)C(=O)CCC3=NN=C(S)N3C COCCOCC(=O)N[C@H1]1CC[C@@H1](NC(=O)[C@@H1]2CCCN2C3=NC=CS3)CC1 CC1=NN(C)C(N)=C1C(=O)N[C@H1]2CC[C@H1]2NC(=O)[C@@H1](C)CN3CCCCC3 CCCN1N=NN=C1[C@@H1](CCCCOC)NCC=2C=C[NH1]C=2 COC[C@](C)(OC)C(=O)N1C[C@H1](O)C[C@H1]1C(=O)N[C@H1](C)C2=NC=C(F)C=N2 CN1CC[C@H1](CCC(=O)NCC2=NC(O)=CC(CNC(=O)C3CC=CC3)=N2)C1 CCC[C@H1](OCC)C(=O)N1CCN(C(=O)C=2C=C(C)[NH1]N=2)[C@H1](C3=CC=NC=C3)C1 CC(C)(C)CNS(=O)(=O)C1=CC=C2[NH1]C(=NC[C@@H1]3CCC[C@H1](CO)C3)SC2=C1 CC1=CC=CC([C@H1](CNC(=O)[C@@H1]2[C@@H1](C)[C@H1]2C)NC(=O)C3=CC(C)=CO3)=C1 C=CC[C@@H1](CNC(=O)[C@H1](O)CSC)NC(=O)C1=CC(Br)=CC(C)=C1C O=C(CC1CCSCC1)N[C@@H1]2C[C@H1](NC(=O)[C@H1]3CCCN(CC(F)F)C3)C[C@H1]2O O=C(CN1CCCC1)N[C@H1]2CCN(C(=O)C3=CC=C4N=C[NH1]C4=C3)C[C@H1]2F C#CC[C@@H1](NC(=O)CN1C=NC=N1)C(=O)N(C)CC2=CCCOC2 CC1=CC(C)=C(C(=O)N2C[C@H1](C)N(C(=O)C3=CC=C4C=C[NH1]C4=N3)[C@H1](C)C2)O1 CN1CCC[C@@H1]1CCC(=O)N2C[C@@H1]3C[C@@H1]3[C@H1]2C(=O)N4CCO[C@@H1](CC(N)=O)C4 CC1=CC(C(=O)N2CC[C@H1](NC(=O)C=CC3=CC=C(O)C=C3)C2)=CC=C1C4CC4 CCOC(=O)C1(CC(=O)N(C)[C@@H1]2CCCN(C(=O)C(C)(C)C3CC3)C2)CCC1 COC(CC1=CN([C@@H1](C)CNC(=O)CCC2=C[NH1]C(=N)[NH1]2)N=N1)OC N1=C[NH1]C(CCNC2=CC(=NCC3=CC=C(C4=CC=CS4)S3)[NH1]C=N2)S1 CC[C@@H1]1CCC[C@@]1(C)C(=O)N2CCC[C@]3(NC(=O)C4=NOCC4)CCC[C@H1]23 COC1=C(F)C=CC(C(=O)N(C)[C@@H1]2CN(C(=O)[C@@H1]3C[C@@H1]3F)CC[C@@H1]2O)=C1F CN(CCN1CCN(C(=O)CC2=CC(F)=CC=C2Cl)CC1)C(=O)[C@H1]3C[C@H1]3Cl C[C@H1]1OC2(CO)CC1(C(=O)N[C@@H1]3CN(C(=O)C4=C[NH1]N=C4F)C[C@@H1]3O)C2 C=CC1(C(=O)N2CC=C[C@@H1](NC(=O)[C@@H1]3CCCCN3CCC)C2)CC1 CC1=CC2=CC(C(=O)N3[C@H1]4CC[C@H1]3[C@H1](CNC(=O)C5(C)CCCC5)C4)=CC=C2[NH1]1 N#CC1(C(=O)NC[C@H1]2[C@H1](O)[C@H1](O)CN2C(=O)CSC3=CC=C(F)C=C3)CCC1 CC1=CC=C(C(=O)NC[C@@H1]2CC(C)(C)CN2C(=O)[C@@H1](C3CC3)[C@@H1]4CCCO4)N=C1 O=C([C@@H1]1CCC[C@H1](NS(=O)(=O)C2=CC([N+1](=O)[O-1])=CC=C2Cl)C1)N3C[C@@H1]4CCC[C@H1]4C3 CC[C@H1](C)[C@@](C)(O)CNC(=O)[C@H1](CC(F)F)NC(=O)C1=CC=C(CO)O1 COC(=O)[C@@H1](OC)C(=O)NC[C@]1(C)CCN(C(=O)CCC2=NC(CSC)=NO2)C1 O=C(C#CC1CCOCC1)N[C@@H1](C(=O)N[C@@H1](CO)C2=CC=CC=C2)C3(O)CCC3 CC(C)(C(=O)NC[C@@H1]1CCC[C@H1]1NC(=O)C2(CC3=CC=CC=C3)CCC2)C(F)F CCCC=1ON=C(C)C=1C(=O)N[C@@H1]2CC[C@H1]2NC(=O)[C@H1](C)N(C)CC(F)(F)F N#CC1=CC=CC=C1C=CC(=O)N2CC[C@@H1](NC(=O)C3=CSC(Cl)=C3Cl)[C@H1](F)C2 C[C@H1]1CCO[C@H1]1C(=O)N2CC[C@H1](CCNC(=O)C3=N[NH1]C4=C3CCSC4)C2 CCCC1CC(C(=O)N[C@@H1]2CC[C@H1](CCC(=O)NCC3=CCCN(C)C3)C2)C1 CCOC(=O)C1=CC=CC([C@H1](C(=O)NC)N2CCC3=C(CCCC3)[C@@H1]2C)=N1 CNS(=O)(=O)CCC(=O)N[C@H1]1CN(C(=O)C2(CC(C)C)CCC2)CC13CC3 C[C@H1](CNC(=O)[C@]1(C)CC=CCO1)NC(=O)C2=CC=CC(C3=NC(O)=N[NH1]3)=C2 CCCCOC(=O)C=CC(=O)N1CCC(CN(CC)C(=O)C(=O)NC(C)C)CC1 CC1(C)NCC[C@H1]1N2CCCC[C@@H1]2C3=CC=CC(C(C)(C)C)=C3 CN1C=C2C(=N1)CC[C@@H1](C(=O)NC[C@]3(C)COCCN(C(=O)C(C)(C)C)C3)C2 N#CC1=CC=C(NC(=O)CC2(O)CCN(C(=O)COC3=CC=CC=C3)CC2)C=N1 CC1=CC(F)=CC(C(=O)N2CCC(CNC(=O)C3=CN=C(S)N=C3)CC2)=C1C CC1=CC(Cl)=C(Br)C=C1NC(=O)[C@H1]2CCN3C=NN=C3C2 CC1=CC(Br)=C(Cl)C=C1C(=O)NC[C@@H1]2CC3(CO2)CN(C(=O)CO)C3 CC[C@@H1](C)OCC(=O)NC[C@]1(C)CN(C(=O)C2=CN(CCF)N=N2)C(C)(C)C1 C[C@H1](C(=O)N1CCC[C@@H1](C#N)C1)N(C(=O)CN(C)C)C2CC2 C[C@@H1](F)CC(=O)N[C@H1]1CCCN(C(=O)C(C)(C)C2CCCCC2)CC1 CCN1N=C(C)C=C1C(=O)N(C)C[C@@H1](C)C(=O)N2CC[C@@H1]2CC(=O)NC N[C@H1]1CO[C@H1](CNC(=O)C(=O)NCC2CC(O)(C3CCC3)C2)C1 CO[C@@H1]1CCN2C=C(C(=O)NCCCN(CCO)C(=O)CC=3C=NOC=3)N=C2C1 CC1(C)C[C@@H1](NC(=O)C2=CCOCC2)CCN(C(=O)C3=CC=CC(F)=C3F)C1 COCC12CC(CNC(=O)CN(C)C)(CN1C(=O)CN3CCC[C@H1]3C)C2 C=CC(F)(F)C(=O)N1CC[C@H1](N(C)C(=O)C2=CC=C(Br)O2)[C@@H1](C)C1 CN1C[C@@H1](C(=O)N2C[C@H1](C(=O)N(CCO)C3CC3)CC(C)(C)C2C)CCC1=O C=C1CC[C@@H1]1C(=O)NC(C)(C)[C@@H1]2CCN(C(=O)CCN3CCOC3=O)C2 CC1=NN(C)C(N)=C1C(=O)N2CCC3(CC(NC(=O)CCCS(C)(=O)=O)C3)C2 O=C(CSCC1=CSC=N1)NCC2(NC(=O)CN3CC=CC3)CCCC2 C=C(C)C[C@H1](C)C(=O)N1CC(O)(CCNC(=O)C2=CN=CC(OC(F)(F)F)=C2)C1 CCCC(C)(C)CC(=O)N1C[C@H1](O)C[C@@H1]1CNC(=O)CSCC2=CSC=N2 CNC(=O)[C@@H1](C1=CC(F)=NC(F)=C1F)N(C)CC2=CC(C)=CS2 CC[C@@H1](CN(C)C(=O)C=C1CCN(C)C1)NC(=O)[C@@H1](CC(C)C)NC(=O)OC COC1=CC=CC(Br)=C1C(=O)N[C@@H1]2CN(C(=O)C3=C(C)C=CC(C)=C3O)C[C@@H1]2F CC=1N=NN(CC(=O)N2CC(OCCNC(=O)[C@H1]3COCCN3C(C)C)C2)N=1 CC(C)S[C@H1](C)C(=O)N1[C@@H1](C(=O)N2CC([C@@H1]3CCCO3)C2)CC[C@@H1]1C4CC4 COC1=NC=C([C@@H1](C(=O)NCC2CC2)N3CCC34CCC(CO)CC4)C=C1C CC1=CC=C(C(=O)N[C@H1](C)CCNC(=O)CCC2=CC=C(Cl)C(OC)=C2)C(F)=C1 CCC1=C[NH1]N=C1C(=O)NC[C@H1](C)[C@H1](F)C(=O)N[C@](C)(CO)C(=O)OC CCN1CCC[C@H1]1C(=O)N2CC(C)(NC(=O)CSC3=CC=C(C(C)=O)C=C3)C2 COC1=CC(O)=CC(NC(=O)[C@H1](CN2C=CC=N2)NC(=O)C3=N[NH1]C(C)=C3C)=C1 CC1=CC(C)=CC(C(=O)NC2(C(=O)N3CC[C@@H1]([C@H1]4CCCO4)C3)CSC2)=C1 CCC(=O)N(C)C1=CC=CC=C1C(=O)NCCNC(=O)CO[C@H1]2CCCC[C@H1]2C C#CC1=CC=C(C(=O)N2C[C@@H1]3C[C@H1](C2)CN3C(=O)[C@@H1]4C[C@H1](CC)C4(C)C)C=C1C CC(C)[C@@H1](C)C(=O)N1CCC(C)(C2=CN(CCCOC3CCC3)N=N2)CC1 CC(C)N(C(=O)[C@H1]1CC12CC(NC(=O)[C@@H1]3[C@H1](C#N)C3(C)C)C2)C4CC4 CC(C)C1=CC=C2OC=C(C(=O)N(C)CCN(C)C(=O)CCC[C@@H1](C)O)C2=C1 CN(C(=O)C[C@H1]1CCN(C(=O)C2=NC=CC=C2F)C1)[C@@H1]3CCOC3 CCSC1=CN=CC=C1C(=O)NC2CCC3(CC2)CN(C(=O)C4=C(C)OCC4)C3 COC(=O)[C@H1](NC(=O)C1=CC=CC([C@H1]2CCCO2)=C1)C3=CC=CC(C)=C3C N=C1[NH1]C(C2CC2)=NC=C1C(=O)N3CC[C@H1](NC(=O)[C@@H1]4CCN5CCOC[C@@H1]45)C3 CCOCC(=O)NC[C@H1]1CN(C(=O)[C@H1](C)C=2C=C(C)OC=2C)CC1(F)F CC1(C)C2CCC1(C(=O)NCC3[C@@H1]4CN(C5=C(Br)C=CC=C5[N+1](=O)[O-1])C[C@@H1]34)CC2 CCCC1(NC(=O)CN2CCC(C)(C)C2)CCN(C(=O)C=CC3CCCC3)CC1 C[C@@H1](CCNC(=O)C1=CSC(C=2C=N[NH1]C=2)=N1)NC(=O)C3=NNC(=O)C3 CC=1C=NN(CCN[C@@H1](C2=CC=C(F)C=C2C(F)(F)F)C3=NN=NN3CC)C=1 CCO[C@@H1]1C[C@H1]1C(=O)N2CC[C@](C)(NC(=O)CCCCC(C)(C)OC)C2 CNC(=O)N[C@@H1](C)C(=O)N[C@@H1]1CN(C(=O)COC[C@H1]2CCCO2)CC[C@H1]1O CC1=NC2=CN=CC(C(=O)N(C)[C@H1]3CCN(C(=O)[C@H1](C)O)C[C@@H1]3C)=C2[NH1]1 COC1(C(N)=O)CN(C(=O)[C@@H1]2[C@H1](C)CCN2C(=O)C34CC(C)(CCO3)C4)C1 OC1=CC=C2C(NCC3=CC=C(Br)C=N3)=NC=NC2=C1 O=C(NCC1(F)CC(N=C2[NH1]C=CN=C2F)C1)C=3C=C(C4=CC=CN=C4)ON=3 CC1(CNC(=O)CN2CCN(C(=O)C3=CC=C([N+1](=O)[O-1])O3)CC2)COC1 COC=1OC(C)=NC=1C(=O)NC[C@H1](C)CNC(=O)[C@]2(Br)CC2(F)F CCOC(=O)CNC(=O)N1CCN[C@H1](C(=O)NCC(=O)N2[C@@H1](C)CCC[C@@H1]2C)C1 COC1=CC=C2[NH1]C=C(CC(=O)NCCN3C=C(C(=O)O)C=N3)C2=C1 C#CC[C@@]1(C(=O)NCC2=NC=CC(C)=C2F)CCN(C(=O)[C@@H1](C)OCC(C)C)C1 CC1=CN=C(C(=O)N(C)[C@H1]2CCN(C(=O)C3=NC=C(Br)C=N3)C[C@H1]2C)C=N1 CNC(=O)CCCC(=O)NC[C@@H1]1CCCN1C(=O)[C@@H1](C)C(=O)OC COC(=O)[C@H1]1C[C@H1](C(=O)NCC[C@H1](O)CNC(=O)C(C)(C)CS(C)(=O)=O)C1 CC1=CC=CC(OCC(=O)N2CCCC3(CCN(C(=O)C(F)F)CC3)C2)=C1 CCCCS[C@H1](C)C(=O)N[C@H1](C)[C@H1]1CN(C2=CC=CC(F)=C2[N+1](=O)[O-1])CCO1 O=C(CCC1=CC=CS1)N2CCN(C(=O)C3=CC=C4C(Cl)=CC=CC4=C3)CC2 COC(=O)[C@@H1]1O[C@@H1](C(=O)N2CC3=NC=CN3C[C@H1](NC(=O)C=4C=C[NH1]N=4)C2)C[C@H1]1C COCC1(CC(=O)N2CC(C3=CN(C4=NC=C(C)S4)N=N3)C2)CCCC1 CCN1CCC(C(=O)N[C@H1](C)CNC(=O)CC2=CC(F)=CC=C2C)CC1 CCCNC(=O)[C@H1](C1=CC=C(C2=CC=C(Cl)C=C2)O1)N3C[C@@H1](C)C[C@@H1](CC)C3 CCC[C@H1](C)[C@H1](C)NC(=O)C1(CCNC(=O)C2=CC(=N)[NH1][NH1]2)CCCC1 CCO[C@@H1](C(=O)NC[C@@H1](C1CC1)N(C)C(=O)CC(COC)COC)C2CCCC2 CC1=COC(CNC(=O)C2(NC(=O)[C@H1]3CCOC3(C)C)CCCCC2)=C1 CC[C@@H1](O)[C@H1](C)C(=O)NCCC[C@@H1]1CCCN1CC2=NC=CN2C(C)C CC(C(=O)N(C)CCCCCNC(=O)[C@@H1]1C[C@@]1(C)Br)=C2CCC2 CCOC(=O)[C@@H1](C(=O)NCCCN(C)C(=O)[C@H1]1CCCCC1(F)F)C(C)C C[C@@H1]1C(=O)N(CC(=O)N[C@@H1]2CCCN(C(=O)CC[C@H1]3CCCO3)[C@@H1]2C)C(=O)[C@@H1]1C C#CC[C@@H1](C)C(=O)N1CCN(C(=O)C=2C=CN(CCF)N=2)[C@H1](C3=CC=CN=C3)C1 C#C[C@@H1](NC(=O)CC[C@]1(C)CCCN1C(=O)C2=C[NH1]C(C#N)=C2)C3CCCC3 CON(CCC(=O)N(C)[C@@H1](C)[C@@H1]1CCCO1)C(=O)CCCC(C)C CC1=CC(C(=O)NCC=2C=C[NH1]C=2C(=O)NC[C@]34CCCC[C@H1]3C4)=CO1 CCC=1C=CSC=1C(=O)N(C)CCN(C)C(=O)C2=C(C)OCC2 C[C@H1](CNC(=O)C[S@@](=O)CCC(F)(F)F)CN(C)C(=O)C1(CCF)CCOCC1 C[C@H1]1CC[C@@H1](C(=O)NCC2(CNC(=O)C3=CC(Cl)=C(Cl)S3)CC2)S1 CC[C@](C)(CCNC(=O)[C@H1]1CNC(=O)C1)NC(=O)CCNS(C)(=O)=O COC(=O)[C@H1](C)NC(=O)C1CN(C(=O)CC2=CC(C(F)(F)F)=CC=C2C)C1 CN1CC(NC(=O)C[C@H1](CC2=CC=CS2)NCC3=CC=C(Cl)N=C3Cl)C1 COCC1(C(=O)N(C)CCN(C)C(=O)C=2N=CSC=2C(F)(F)F)CCC1 C[C@@H1]1C[C@H1]1CCCN=C2[NH1]C(=NCCCC(=O)N(C)C)C3=CC(Cl)=CC=C3[NH1]2 CC[C@H1](CCC(=O)N1[C@H1]2CC[C@H1]1CN(C(=O)[C@@H1](C)NS(C)(=O)=O)C2)OC COC(=O)C=CC1=CC=C(NCC2=CC(Cl)=C(Br)C=C2O)N=C1 CN(C[C@@H1]1CN(C(=O)C2=CC(O)=CC(N)=C2Cl)CCO1)C(=O)[C@@H1]3C[C@H1]4CC[C@H1]3O4 N#CC1=CC=CC(C#N)=C1NC[C@H1]2CC[C@@H1](C(=O)O)O2 COCC=1C=CSC=1C(=O)N(C)CCNC(=O)C2=CC=C(C3=CC=CC=N3)S2 CC(C)C[C@@H1](C(=O)NC[C@H1](C)CN(C)C(=O)C1=NN=C2N1CCCCC2)N(C)C CNC(=O)[C@H1](C1=CN=C(C2CC2)S1)N(C)[C@H1]3CNC(=O)C34CC4 CC1=CC=C2OC=C(C(=O)N3CCCC[C@H1]3CCNC(=O)[C@@H1](C)C4CC4)C2=C1 CO[C@H1]1C[C@H1](CC(=O)N2CC[C@@H1](CNC(=O)C(=O)C3=CSC(=N)[NH1]3)C2)C1(C)C CC(C)(C(=O)N1C[C@H1](CNC(=O)CC#N)C2(CCC2)C1)[C@H1]3CCCO3 CCN(C(=O)CC1=CC=C(O)N=C1)C2CCN(C(=O)[C@@H1]3CC4=CC=CC=C43)CC2 CC1=CC(C(=O)N[C@H1]2CCN(C(=O)[C@H1]3CCC4=CN=CN4C3)[C@H1]2C)=CC(C)=C1F CCO[C@H1](C)C(=O)N[C@@]1(C)CCN(C(=O)C=2C(C)=NN(CC(C)C)C=2Cl)C1 O=C(NCC1=CC=CC=C1I)[C@H1]2[C@H1]3CN(C(=O)C4=CC(Br)=CC(Br)=C4)C[C@H1]32 C[C@@H1](CNC(=O)C=CC1=CC=C(C(N)=O)C=C1)CNC(=O)C=C2CC[C@H1](C)C2 COC=1C=C(C)SC=1C(=O)N2CCC3(CCCN3C(=O)[C@H1]4C=CCC4)CC2 CC(C)(C)N1C=C(C(=O)N[C@@H1]2CCC[C@H1]2CNC(=O)C3=CN4C(=N3)CCC4)N=N1 CCO[C@H1](C)CCC(=O)N[C@@H1](CC)C(=O)N(C)[C@H1]1CCSC1 CC[C@@H1](CNC(=O)C1=CC=C(OC)N=C1Cl)NC(=O)C2=C(C)C=C(F)C=C2C O=C1CC(=O)N[C@H1](C(=O)N2CC([C@@H1](O)C(=O)N3CC(N4CCC4)C3)C2)C1 CCOCC(=O)N(CCNC(=O)[C@H1](O)CN1C=NC=N1)CCC2=CC=CC=C2 COC1=CN=C(C(=O)N[C@H1]2CCN(C(=O)C(C)(C)OC)CCC2(F)F)C=N1 CSCCCC(=O)NC[C@H1]1C[C@H1](NC(=O)[C@@H1]2CCC3=N[NH1]C=C3[C@H1]2C)C1 CC1=NC=CC=C1C(=O)N2C[C@H1](O)[C@H1](NC(=O)CC3=COC4=CC(F)=CC=C34)C2 C[C@@H1](CNC(=O)[C@]1(C)CCC(F)(F)C1)N(C)C(=O)C2=CC=C(C#N)C=N2 CCCC[C@H1](O)C(=O)NCC1CCN(C(=O)CC2=CSC(CC)=N2)CC1 CC1(NC(=O)CSC2=N[NH1]C(O)=N2)CC(NC(=O)[C@H1]3CCCC4=NC=CN43)C1 CCC=1OC(C(=O)N[C@H1](C(=O)NO[C@H1](C)CC)C2CCCCC2)=CC=1C CC1=CC(C(=O)N2CCC[C@H1]2C(=O)N3CCN=C3)=CN=C1C(F)(F)F CC(C)N(CCC(=O)NCC[C@@H1]1CCC[C@H1]2C[C@@H1]12)C(=O)C3=C(Cl)CCOC3 CCO[C@H1](C)C(=O)N1C[C@H1]2[C@@H1](NC(=O)C=3C=NN(CC)C=3CC)CO[C@H1]2C1 C=CCCCCCCNC(=O)[C@@](C)(C1CC1)N(C)C(=O)CC2=C[NH1]N=C2C C#CC(C)(C)C(=O)N1CCN(C(=O)[C@@H1](CO)C2=CC=CC=C2)C[C@@](C)(F)C1 CCOC(=O)C1CC(NC[C@H1](O)[C@H1]2C[C@@H1]3CC[C@H1](C2)N3C(=O)OC(C)(C)C)C1 CCN(CC)CC(=O)NCC1=CC=C(CCNC(=O)[C@@H1](F)OC(F)(F)F)C=C1 CC=1[NH1]N=C(C(=O)N(C)[C@H1](C)CCNC(=O)C2=CN(C)C3=CC=C(F)C=C23)C=1C CO[C@H1]1CCCC[C@H1]1C(=O)N2CCN(CCNC(=O)C3=CC=C(N)C=C3Cl)CC2 CCO[C@@H1](C(=O)N[C@H1](C(=O)N1C[C@@H1]2C[C@@H1]2[C@@H1]3C[C@@H1]31)C4=C(C)C=CC=C4Br)C(C)C CC1(CNC(=O)[C@@H1]2CCC3=N[NH1]C=C3C2)CCN(C4=NC=C(Cl)C(O)=N4)CC1 C=C(Cl)C(C)(C)C(=O)N1CC[C@@H1](C(C)(C)C)C[C@H1]1CNC(=O)[C@@]2(C#N)CCCO2 O=C(NCC=1C=NN(C2=CC=CC=C2)C=1)N3CCC[C@](O)(C(F)(F)F)CC3 C[C@@]1(NC(=O)C=2C=C3N(N=2)C[C@@H1](F)C3)CCN(C(=O)C4=CN=C(Cl)C(Cl)=C4)C1 CN(CCOCCNC(=O)[C@@H1]1CN2CC[C@H1]1C2)C(=O)C3=C[C@]4(CCOC4)C3 O=C(C[C@H1]1CCOC1)N[C@@]23CCC[C@]2(F)CN(C(=O)[C@H1](O)C4CCCC4)C3 CC=1C=COC=1CC(=O)NC[C@]23CCCC[C@@H1]2N(C(=O)C4=NC=CC=C4N)CC3 CCN=C1C=CC(C(=O)NC[C@H1]2CCCC[C@@H1]2NC(=O)C3(N(C)C)CCC3)=C[NH1]1 C[C@H1](O[C@H1]1CCOC1)C(=O)N[C@@H1]2CCCCN(C(=O)C3=CC4=NC=CN4C=C3)C2 COCC=1N=C(C=2C=NN3C=CC=CC=23)N(C4=CC=C(S(C)(=O)=O)C=C4)N=1 C=CC(C)(C)CC(=O)NC1(CO)CN(C(=O)[C@H1](CCC2=CC=C(F)C=C2)OC)C1 C[C@H1](O)[C@H1](C(=O)NC[C@@]1(C)CCCN1C(=O)C2=CC=CC(N)=C2O)N(C)C CCOC(=O)CCCC(=O)NCC1=CSC(C(=O)N(C)C2(C3CC3)CC2)=C1 CC[C@@](C)(CO)C(=O)NC[C@H1]1CCCC2(CN(C(=O)CN3CCSCC3)C2)O1 CC(C)(CNC(=O)C1=CC=CC=2N=CSC1=2)NC(=O)C3=CC(C(F)(F)F)=NS3 CN(C[C@H1]1CCCN1C(=O)C2=CN=CC(Cl)=C2Cl)C(=O)[C@]3(C)CCCS3 CCO[P@](C)(=O)CNC(=O)C(C)(C)C1=CCN(C(=O)CC2C[C@H1]3C[C@@H1]3C2)C1 CN1C=C(C(=O)N[C@]2(C)C[C@@H1](NC(=O)C3=C(F)C=CC=4C=COC3=4)C2)N(C)C1=O C[C@H1](CNC(=O)C=1C=NC2=CC=NN2C=1)N(C)C(=O)[C@@]3(F)CCOC3 CC1=C(C#N)C=CC=C1C(=O)NCCCNC(=O)C=2C=CC(=NCC3CC3)[NH1]C=2 CC1=CC(Cl)=CC=C1C(=O)NC[C@@H1](C)CN=C2[NH1]C=NC=3C(Br)=NN(C)C2=3 CCCCC[C@H1](C(=O)NCC=1C=C2N(N=1)CCN(C(=O)C[C@H1](C)O)C2)C(C)C CS[C@@H1](C)C(=O)N1CC[C@]2(CCOC2)[C@H1](CNC(=O)CCCS(C)(=O)=O)C1 NC(=O)C=CC(=O)N1CC2(CCOCC2)C[C@@H1]1CNC(=O)CC3OCCCO3 C#CCCC[C@@H1](C)C(=O)N[C@@H1](C(=O)NC(C)(C)C(=O)NCC)C1=CC=NN1C CC1=NC(C)=C(C(=O)N2CCC[C@H1]2C3(O)CN(C(=O)[C@@H1](C)OC(C)(C)C)C3)[NH1]1 CCCC[C@H1](C)C(=O)N[C@H1]1C[C@H1](CNC(=O)[C@H1](OC2=CC=CC(C)=C2)C(C)C)C1 C[C@@H1](NC(=O)CCC1CCC1)C2CN(C(=O)C=3C=C(CC4CC4)ON=3)C2 C[C@H1]1CN2CCC[C@@H1]2CN1C(=O)CSCCNC(=O)C#CC(C)(C)C C[C@@H1](CCN(C)C(=O)C(F)(F)CO)NC(=O)[C@@H1](C)C1=C[NH1]C2=CC=CC=C12 CC(C)NC(=O)N1CC(C(=O)N2CC(CO)(NC(=O)[C@@H1]3CCCN3C)C2)C1 C[C@H1](NC(=O)C1=CC=C2N=C[NH1]C2=C1F)C3CN(C4=NC=C(OC(F)F)C=N4)C3 C[C@@H1](CC1CC1)C(=O)N(C)C[C@H1]2CN(C(=O)C(C)(C)C3=CC=C(F)C=C3)CCO2 CC1=CC=C(OCC(=O)N[C@H1]2C[C@H1](O)CN(C(=O)C=3C=NC(=N)[NH1]C=3)C2)C(C)=C1 COC1=CC=C(CC(=O)N[C@@H1]2CN(C(=O)[C@H1](CCSC)OC)C[C@@H1]2F)N=C1 CC[C@@H1](CNC(=O)C=1C=C[NH1]C=1)NC(=O)C2=C(C)C=NN2C CCS(=O)(=O)CC(=O)N1C[C@H1](NC(=O)C2=NN(C)C=C2[N+1](=O)[O-1])[C@@H1]3C[C@H1]31 CC[C@@H1](C(=O)N1C[C@H1](CC)[C@@H1](C(=O)N[C@@H1](C)C(F)(F)F)C1)N(CC)CC C[C@H1]([C@H1](F)C(=O)NC[C@]1(C)CCCN1C(=O)CCN=C2[NH1]C=CS2)C(F)(F)F CC(C)(C)[C@@H1](CO)CNC(=O)CN1C=C(CNC(=O)C=2C=NSC=2)N=N1 CO[C@]1(CNC(=O)[C@H1](O)C2=CC=CN=C2)CCN(C(=O)[C@]3(C)CCCNC3=O)C1 C[C@@H1]1C[C@H1](O)CCN(C(=O)[C@@H1]2C3=C[NH1]N=C3CN2C(=O)CCN4CCCCC4)C1 C=CCCC(=O)N[C@]1(CC=C)CCN(C(=O)COC2=C(C)C=C(Cl)C=C2C)C1 C=CCN1C=CN=C1C(=O)N[C@@H1](C)[C@H1]2CCN(C3=NC=NC4=CC=CC=C34)C2 CC1(C)CCCC[C@H1]1CC(=O)NC[C@H1](NC(=O)CS(C)(=O)=O)C(C)(C)C COC1=CC=CC(CCC(=O)NCC[C@@]2(O)CCCN(C(=O)[C@@H1](C)CF)C2)=C1 CC1=CC(Cl)=C(Cl)C=C1C(=O)NCC2(CCNC(=O)[C@H1](C)N3C=CN=N3)CC2 CC=1N=C2C=CC=C(C(=O)N3CC4(CC(NC(=O)C5=CC(Cl)=NS5)C4)C3)N2N=1 C[C@H1](NC(=O)CN1CCS(=O)(=O)CC1)[C@@H1]2CCCN(C(=O)CC3=CN=NS3)C2 CSCCCCCC(=O)N[C@@H1](CNC(=O)C=1C=C(C)N(C)C=1C)C2CC2 CN1N=C(C(=O)N[C@@H1]2CC[C@H1]2CNC(=O)[C@H1]3COC4(CCC4)C3)C=C1O COC1=CC=CN=C1C(=O)N2C[C@H1]3C[C@H1](N=C4C=C[NH1]C(C(F)(F)F)=N4)C[C@H1]2C3 CCC(C)(C)CCNC(=O)C1CC2(CC(NC(=O)CCOCC3CC3)C2)C1 C[C@@H1]1CC[C@H1](CC(=O)N2CC(CO)(NC(=O)C3=CC=CN=C3O)C2)C1 O=C(NC[C@@H1]1CCN(C(=O)C2=CC(Cl)=C(Cl)C=C2F)C1)[C@H1]3CCCOC3 CC[C@H1](C)[C@H1](OC)C(=O)NC1(C)CCN(C(=O)CC2(CO)CCCC2)CC1 CC=1N=C(O)[NH1]C=1C(=O)N(C)[C@@H1]2CN(C(=O)C=3C=C(CN(C)C)ON=3)CC2(C)C COC(=O)C1=NSC(N2CC3(C2)OC4(C)CC3(NC(=O)[C@@H1]5CO[C@@H1](C)C5)C4)=N1 CC(C)=C(Br)C(=O)N[C@@H1]1C[C@H1]2[C@@H1]1CCN2C(=O)C3=CC(C(C)C)=NO3 [N-1]=[N+1]=N[C@H1]1CCOC2(CCN(C(=O)C3=CC=C(Br)C(Cl)=C3Cl)CC2)C1 O=C1CC[C@H1](C(=O)NCC2(NC(=O)C3=CC=CC(=S)N3O)CCCC2)CN1 O=C(NCCCF)[C@@H1]1CC[C@H1](C2CC2)N1C(=O)C=C3CCOCC3 CNC(=O)CCCCCNC(=O)NCC1CCC2(CCCCCC2)CC1 CC=1C=NC(=NC[C@]2(C(C)(C)C)CCN(C(=O)[C@H1]3CCCC(C)(C)C3)C2)[NH1]C=1 CC(=O)CN(C)[C@H1](C(=O)NC1=CC=CC=C1C)C2=CC=C([N+1](=O)[O-1])C=C2Cl CC1=CC=C(C(=O)N[C@H1]2C[C@H1](NC(=O)C3=CN=C4N3CCCC4)C2)C(O)=N1 C[C@@H1](CNC(=O)CC12CCC(CC1)C2)NC3=CC=C([N+1](=O)[O-1])C(OC(C)(C)C)=C3 CCCC[C@@H1](CCC)NC(=O)[C@@H1]1CCC2(CC2)N1C(=O)C3(C4CC4)CC3 CC1=C(C(=O)N2CC3(CO)CC2(CNC(=O)[C@@H1]4CCN(C)C4)C3)N=NN1C C[C@@H1](CN(C)C(=O)[C@H1]1CCC2=CC=CC=C21)C(=O)N3CC4(C3)OC(=O)N[C@H1]4C COC1=CN=NC(C(=O)NC[C@@H1]2C[C@@H1]3C[C@@H1]3N2C(=O)CNC(=O)C4CC4)=C1 CCCC[C@H1](O)[C@H1](C)C(=O)N1CC[C@H1](C(=O)N(C)C[C@@](C)(O)C2CC2)O1 CC1(NC(=O)[C@H1](C2=CC=C(C(C)(F)F)C=C2)N3CCSCC3)CCCC1 CC1=CC(C(=O)N2CCN(C(=O)C(F)(F)Cl)C[C@@H1]2C#N)=NC=C1[N+1](=O)[O-1] CC=1C=NN(C)C=1S(=O)(=O)N(C)C2CCN(C)CC2 CO[C@@](C)(C(=O)N1CC[C@H1](CCC(=O)N2CC(OCC(N)=O)C2)C1)C3(C)CC3 CC=1SN=NC=1C(=O)N2CC[C@@H1]3[C@@H1](CCCN3C(=O)CCCCC(C)C)C2 CC(C)OCC(=O)NC[C@]12CC[C@H1]1CN(C(=O)[C@@](C)(O)CN3C=CC=CC3=O)C2 C/C=C/C[C@H1](CC)C(=O)NCC[C@H1]1CC[C@@H1](NC(=O)CC23CCC(CC2)OC3)C1 CCCC(C)(C)C(=O)N[C@@H1](C)[C@@]1(O)CCN(C(=O)C2=C[NH1]N=C2S(N)(=O)=O)C1 CCCC(=O)N1CCC(CCCCCNC(=O)[C@H1](OC(C)(C)C)C(C)(C)C)CC1 CC(C)N(CCCCCNC(=O)CC1=CC=CN1C)C(=O)C2CC3(CCCO3)C2 CN1C2C(CC(CNC(=O)N[C@]3(C(F)(F)F)C[C@H1]3Br)C2)C1 COC1=N[NH1]C=C1C(=O)N(C)[C@@H1](C)C(=O)N(C)[C@@H1](C)C#C CC1=CSC(CN(C)C2=NN=C([C@@H1]3OCCC3(C)C)N2[C@H1]4CCS(=O)(=O)C4)=C1 CCN1C=C(CNC=2[NH1]C(=NCC3(C)CS(=O)(=O)C3)N=C4N=CN(C)C=24)N=N1 O=C(N[C@H1]1C[C@@H1](CO)N(C(=O)[C@@H1]2CC2(Cl)Cl)C1)C3=CC=4N=C[NH1]C=4C=N3 CCC1(C#CC(=O)N[C@@H1](C)CNC(=O)C[C@@H1]2CC(=O)C3=CC=CC=C32)CC1 CC1=NN(CC(F)F)C=C1C(=O)N(C)[C@@H1]2CCN(C(=O)C=3C=CON=3)C2 C[C@@H1]1CN(C(=O)C2(CCS(N)(=O)=O)CCC2)C[C@@H1]1NC(=O)C=C3CCCCC3 CO[C@@H1](CNC(=O)CC=1C(C)=NOC=1C)CC(=O)N2CC[C@H1](O)[C@@H1]2C CC[C@H1](C(=O)N1CC(CNC(=O)CO)C1)NC(=O)OC(C)(C)C C[C@@H1]1C[C@H1](CNC(=O)[C@H1]2OCCN(C)C2=O)CN(C(=O)[C@H1]3CC=CCC3)C1 CC[C@@H1]1CCN(C(=O)C2=CC3=CC=CC=C3O2)[C@@H1]1CNC(=O)[C@H1](C)CO CCN1CCCC[C@@H1]1C(=O)N[C@@H1]2C[C@@H1](NC(=O)C3=CC(CO)=CC=C3Cl)C[C@H1]2O CC(C)(CCC(=O)N1CCC(F)(F)CC1)NC(=O)[C@@H1]2CCC3(CCC3)C2 O=C(C1=COCCC1)N2CCC3(CC2)CN(C4=NC=NC5=CN=CC=C45)CCO3 CCC(=O)N1CC[C@H1](N=C2N=C(N3CCOCC3)[NH1]C(=N[C@@H1](C)[C@H1]4CCOC4)[NH1]2)C1 C=CC1(C(=O)N2CCC[C@@](CO)(NC(=O)C=C(C)C(C)C)C2)CCCC1 CC1=NC=C(CN2C[C@H1]3CN(C(=O)C4=N[NH1]C=C4Br)C[C@H1]3C2)C=N1 CCC1=NC(C(=O)NC[C@@H1](F)CNC(=O)CC[C@@H1]2C(=O)NN=C2C)=CO1 CSC1=C(C(=O)N2CCC(CNC(=O)[C@H1]3CCCC[C@H1]3C#N)CC2)CCCC1 CC=1C=NN(C)C=1CC(=O)N[C@@H1](C)[C@@H1]2CCCCN2C(=O)CCNS(C)(=O)=O CCC[C@H1](NC(=O)CCNC(=O)OC)C(=O)NC[C@@H1]1OC(=O)NC1(C)C CC(C)CCSCC(=O)N[C@@](C)(CO)CNC(=O)CN1CCC[C@H1]1C CCC[C@@H1](CCCNC(=O)CN1N=NN=C1C=2C=CSC=2)NC(=O)CCCOC NC(=O)NCCC(=O)N1C[C@H1]2CC[C@@H1](C1)N2C(=O)C3(C4=CC=CN=C4)CCC3 CC#CC[C@H1](C)NC(=O)[C@H1]1COCCN(C(=O)C=2C=C[NH1]C=2CC)C1 CN(C)[C@H1](CO)C(=O)N1CC(C)(OCC(=O)NC(C)(C)CC(N)=O)C1 CC(C)C(C)(C)C(=O)NC[C@H1]1CC(=O)N(C)C1=O C=CC[C@@H1](NC(C)=O)C(=O)N1CCC[C@@](O)(CNC(=O)C(=O)NC2=NC=C[NH1]2)C1 CCC=1SC=CC=1C(=O)N[C@@H1]2C3=CC=CC=C3C[C@H1]2NC(=O)C4=NC(C)=NO4 CCC[C@H1](OCC)C(=O)N1CC[C@H1](CNC(=O)C2(F)CCC2)[C@@H1](O)C1 N#CC[C@@H1]1CCN(C=2[NH1]C(=NCC3=CN=C(O)[NH1]3)N=C4C=2N=CN4C)C1 COC(=O)NC1=CC=CC(C(=O)N[C@@H1]2CCC[C@@H1]2NC(=O)C3CC(F)(F)C3)=C1 O=C1CC2(CNC2)[C@H1](C(=O)NCC3=CC=NC(O[C@H1](F)CC4CC4)=C3)CN1 O=C(N[C@@H1]1CCCN(C(=O)C2(C(=O)N3CCCC3)CC2)CC1)[C@@H1](F)CC4CCC4 CN(C)CC1=CC=CC=C1C(=O)N2CC(N(C)CC3=CC=CC4=C3CCCC4)C2 C[C@@H1](CCCCN)N1CCC(O)(C(C)(C)C(N)=O)CC1 C[C@@]1(N)CN(S(=O)(=O)C=CC2=CC=CC=C2F)CC1(F)F C=C(C)CCCC(=O)N[C@H1]1CCOC12CCN(C(=O)CC(F)(F)Cl)CC2 CN1C=CN=C1C(=O)N2CCN(C(=O)C3=CC(Br)=CC([N+1](=O)[O-1])=C3)C[C@H1]2CC#N C[C@]1(CNC(=O)CCCC2=CC=CS2)CCCN(C(=O)[C@@H1]3CCCC[C@H1]3O)C1 O=C(NC[C@H1]1CC[C@H1](CNC(=O)[C@@H1]2CCC[C@@H1]2O)CC1)C3=C(F)C=C(F)C=C3Cl C[C@@H1](NC(=O)C1=CC=NC=N1)[C@@H1](CO)NC(=O)C[C@H1]2CN(C)C3=CC=CC=C32 CCCCSCCC(=O)N1CCC[C@@H1](NC(=O)[C@H1]2CC[C@H1]3C[C@H1]3CC2)[C@H1]1C C=C(C)CNC(=NCCCC1=CC=C(Br)S1)N2CC[C@@H1](C)[C@H1]2C3=CC=CC=C3 CC(C)C=1C=C(C(=O)N[C@]2(CO)CCN(C(=O)C[C@@H1]3CCC34CCC4)C2)ON=1 C[C@H1](C(=O)N1CC[C@](F)(CNC(=O)C=2C=NN(CC3CCCC3)C=2)C1)N(C)C CC(C)C(=O)NC[C@@]12CCCC[C@H1]1CN(C(=O)C=3C=CC(=O)OC=3)C2 CCC1=CC=CC(C(=O)NC[C@](C)(O)CNC(=O)C[C@H1](O)C2=CC(C)=CS2)=C1N COC[C@H1](OC)C(=O)NCC1=CC=C(C(=O)NCC2=CC=CC=C2O)O1 CCCOCCCC(=O)NC[C@@H1](CO)CNC(=O)C1=NN=CC=C1C CNS(=O)(=O)C1=CC=C(C(=O)N[C@H1]2CCN(C(=O)C3(O)CCCC3)CC[C@@H1]2CO)O1 C#CCCOCC(=O)N(C)CCOCCCNC(=O)[C@@H1]1CC(=O)N[C@H1](CC)C1 COC[C@H1](C)CNC(=O)C1CC(CCNC(=O)[C@@]2(F)CCOC2)C1 C=C[C@@H1](CCC)CC(=O)NC[C@]1(C)CN(C(=O)CNC2=CC=CC=C2Cl)CCO1 C#CC[C@](C)(NC(=O)CC1=CC=C(F)C=C1)C(=O)N2CCC[C@H1](C#C)CC2 CSCCC(C)(C)C(=O)N1CCN(C(=O)CNC(=O)C2=CC(=O)N(C)C=N2)CC1 CC[C@@H1](CC(=O)N1CC[C@H1](C)N(C(=O)C=2C=C(S(C)(=O)N)OC=2C)CC1)C(C)C COCCC1=CC=CC=C1NC(=O)C2=CC=C(C3=CC=CC(Br)=C3)N2C CN(C)C(=O)CN1C=CC(=NCC2=CC=CC(I)=C2F)[NH1]1 COC(OC)C(=O)N[C@H1]1CN(C(=O)C2=CC=3[NH1]C=CC=3C=C2Cl)C[C@H1]1C4CC4 CC(C)[C@H1](O)C(=O)N1C[C@@H1]2[C@@H1](C1)N2C(=O)CCC3=NC=CC=C3F CCCCOC1=CC=C(CNC(=O)N(C)C[C@@H1]2CCO[C@H1]2C)C=C1 CCCCCCN1N=NN=C1[C@@](C)(CCCC)NCC2=CC=C(SCC)C=C2 CCO[C@H1](CC)C(=O)NC[C@]1(C)CC(F)(F)CN1C(=O)C2=CN(C)N=C2SC CC1=CC(C(=O)N[C@@H1]2CCC[C@H1](NC(=O)C3=NC=CN3C(C)C)C2)=C(C)N=C1C CC(C)OCCC(=O)N1[C@H1]2CC[C@@H1]1C[C@@H1]2C(=O)N3CC[C@H1](O)[C@@H1]3C4CC4 CC1=CC(C)=NC(CCNCC2=CC=CC(OC3=CC=CC=C3)=C2)=N1 CC(C)N1C=C([C@@H1](C(=O)NC2COC2)N3CCOC[C@@H1]3C4=CN=CN4C)N=N1 CC(C)(NC(=O)C=1C=CON=1)[C@@H1]2CCN(C(=O)C3=CC=C(C4CC4)O3)C2 CCN1CC[C@H1]1CNC(=O)C2CC3(CCN(C(=O)C=4SC=CC=4F)C3)C2 CC1=CSC(C(=O)N[C@@H1](C)CNC(=O)C2=C(Br)C(C)=NN2C(C)(C)C)=C1 CSC1=NC(C(F)F)=CC(N(C)[C@@H1](C)CNC(=O)[C@H1]2CCC3=C[NH1]N=C3C2)=N1 CCC1=CC(Cl)=CC=C1C(=O)N2C[C@@H1](N)[C@H1](OC)C2 NC1=CC=C(C(=O)N2CCN(C(=O)[C@@H1]3CCC4(CCC4)C3)[C@@H1](C5CC5)C2)N=C1 CC1=C(CN2[C@@H1](C)CC[C@H1]2C(=O)NCC3=CC=NC(C)=C3)C=NN1C CN(CC1=NN=NN1C)C[C@@H1]2CCCN(C(=O)[C@@H1](O)C3=CC=CC(Cl)=C3)C2 C=C1CC(C(=O)N2CCC[C@H1]2CNC(=O)[C@H1]3CCC(=O)O3)(C(F)F)C1 O=C(CC1=CC=C2C(=C1)CCO2)NC3=CC=CC(NC(=O)C4=CC=CC(F)=C4)=C3 CCC1(C(=O)NC[C@](C)(CO)NC(=O)C2=CC(F)=C(F)C=C2Cl)CCC1 C=C(C)C[C@H1](NC(=O)C1=CC=CC=C1O)C(=O)N2CCC[C@@](C)(OC)CC2 CC(C)N(C)CCCC(=O)N[C@@H1]1CN(C(=O)[C@H1](C)C2=CC=NN2C)C[C@H1]1C3CC3 CN1N=C(C(=O)N2CCC3(CC2)CN(C(=O)[C@H1]4CC(F)(F)[C@]4(F)Cl)CO3)C=C1O C=CCCN1CC[C@H1](C)[C@H1](NC(=O)C2=CC=NC=C2OCC)C1 CCC1=C(C)N2N=C(CNC3=CC=CC=C3C(=O)N4CCC5=CC=CC=C54)N=C2N1 CC[C@@H1](CC(=O)N1CCOC[C@H1](CNC(=O)C=2C=C(CC(C)C)ON=2)C1)C3CC3 C#CC[C@](C)(CC)C(=O)N[C@H1](CCC(=O)N1CC(F)C1)C(C)C COC[C@H1](C)CC(=O)N1CCOC[C@H1](NC(=O)[C@]2(C)C=CCCC2)C1 C[C@@H1](OCCN(C)C)C(=O)N1CCCC[C@@H1]1CN(C)C(=O)C2(N3C=NN=N3)CC2 CC=1SC(Br)=CC=1C(=O)O[C@H1]2CC(=O)N(C(=O)CN3C=C(CO)N=N3)C2 CC(=O)CCCC1=CN(C[C@H1](C)NC(=O)C[C@@H1]2CC[C@@H1](C)O2)N=N1 C=CC[C@@H1](C(=O)N1C[C@@H1](NC(=O)CCC2=CN(C)C=N2)[C@H1](OC)C1)C(C)C CC1=C[NH1]N=C1C(=O)N2CC[C@H1]3CC[C@]32CNC(=O)CCC4=CN=CN=C4 COC1=CC=C2C=C(C(=O)N3CC(NC(=O)[C@@H1]4C[C@@]45CCCOC5)C3)[NH1]C2=N1 COC1=CC=C(/C=C/C(=O)NC[C@@H1]2CN(C(=O)CSC3CC3)CC24CCC4)C=C1 CS[C@@H1](C)[C@H1](O)C(=O)N1CC2(CN(C(=O)C3=CC=NC(C=4C=C[NH1]N=4)=C3)C2)C1 C[C@]1(F)CN(C(=O)COCC(F)F)CCN(C(=O)[C@@H1]2CCN(CCO)C(=O)C2)C1 C#CCCCC(=O)N1CC2(CC[C@H1]2NC(=O)C3CCN(S(=O)(=O)C(C)C)CC3)C1 CCCCCOCC(=O)N1CC[C@H1](CNC(=O)C2=CN=CO2)C1(C)C N=C1[NH1]N=C(SCC(=O)N[C@@H1](CNC(=O)C2=CC=CN=C2C(F)F)C3CC3)S1 CC(C)[C@@H1](NC(=O)C1=CC=CC=N1)C(=O)N2C[C@@H1]3C[C@H1](O)[C@@H1](O)C[C@H1]3C2 CC1=C(Cl)C=CC(C(C)(C)C(=O)N[C@H1]2CC[C@H1]2CNC(=O)CC[S@](C)=O)=C1F CO[C@@H1](C)[C@@H1](O)C(=O)NC[C@H1]1C[C@@H1](NC(=O)C2=CC=3SC=CC=3[NH1]2)C1 O=C(CC[C@H1]1CCOC1)N2C[C@@H1]3C[C@H1](NC(=O)C4=CC=NC(O)=C4)C[C@@H1](C3)C2 CCSCCC(=O)NCC1(C(=O)N[C@@H1]2C[C@@H1](O)C2(C)C)CCCC1 CCC1=NN=C(C(=O)N2CC[C@H1](C3(NC(=O)C(=O)NC4=NC=C[NH1]4)CC3)C2)S1 CC[C@H1](C(=O)N[C@@H1]1CCCC[C@@H1]1NC(=O)C2=CC(C(F)(F)F)=C[NH1]2)N3C=NC=N3 CSCC(C)(C)CNC(=O)C1CCN(C(=O)COCCCN=[N+1]=[N-1])CC1 C[C@@H1]1CC(CNC2=NC=C(S(=O)(=O)N3CCC[C@@H1](NS(C)(=O)=O)C3)C=C2Cl)=NO1 CC1=CC(C(=O)N2C[C@@H1]3C[C@@H1](NC(=O)C4(O)CC4)[C@H1]2C3)=CC=5N=C[NH1]C1=5 CCSCCCN1N=NN=C1[C@H1](N[C@@H1]2CCC3(CCC3)C2)C4=CC=CC(C)=N4 CCO[C@H1](CC)C(=O)N1CCC(C2=N[NH1]C(CNC(=O)CCC=C(C)C)=N2)CC1 C[C@@H1](NC(=O)[C@H1]1CCCS1)C2CCN(C(=O)[C@H1]3CCOC3(C)C)CC2 C=CCC(C)(C)CC(=O)N1CCC(C(=O)N(CC)CC(C)(C)O)=C(F)C1 O=C(NC[C@@H1]1CN(C(=O)CCCC2=CN=CS2)CC[C@]13CCOC3)C4=COCC4 CN(C)[C@@]1(C(=O)NCC[C@H1]2C[C@@H1](NC(=O)C3(F)CCCCCC3)C2)CCCSC1 COCO[C@@H1](C)C(=O)NC[C@]1(F)C[C@H1](NC(=O)[C@H1](C)NC(=O)CN2C=NN=N2)C1 CC1=CC(C(=O)N[C@@H1]2CCCN(C(=O)C3=COC4=C(C)C=CC=C34)C2)=CC=C1N CC1=CC=C(CN(C)[C@@H1](C[C@H1](C)C(C)(C)C)C(=O)NC2=CC=CC=C2Cl)C(C)=C1 N#CC1=CC(C(=O)NCC2CC(NC(=O)C3=CSC(Br)=C3)C2)=CO1 CCCCC[C@H1](O)CC(=O)NC[C@]1(C)C[C@H1](OC)CN1C(=O)CCN2C=CC=N2 CC(C)N(CCCNC(=O)C1=C(F)C=C([N+1](=O)[O-1])C=C1Br)C(=O)[C@@H1]2C[C@H1]2C CCO[C@@H1](C(=O)N[C@H1]1C[C@@](F)(CNC(=O)C=2[NH1]C=CC(=O)C=2C)C1)[C@H1]3CCOC3 O=C(CC[C@@H1]1CCCN1C(=O)C2=CC=C(Br)C=C2[N+1](=O)[O-1])N[C@@H1]3CCC[C@H1](O)C3 CC(C)[C@@H1](CN(C)C)C(=O)N[C@H1](CCF)C(=O)N1C[C@H1](O)C[C@@H1](O)C1 CC=C(C=CC(=O)N1CCCN(C(=O)C2CC(CC)C2)[C@H1](CO)C1)CC COC1=CC=NC(C(=O)NC[C@H1](C)[C@]2(O)CCN(C(=O)C=3C=CON=3)C2)=C1 CN(CC1(O)CN(C(=O)C=2SC=NC=2C3CCCC3)C1)C(=O)C4=C[NH1]C(=N)O4 C[C@H1](CNC(=O)C1=NC=NC2=C1CCC2)N(C)C(=O)[C@H1]3CCCC=4N=NN(C)C=43 CCN(CC)CC(=O)N[C@]1(CCOC)CCN(C(=O)[C@H1](C)C2=CC=NC=C2)C1 CCCSCC(=O)N1CC[C@@H1](OCCNC(=O)C2=CN=C(C(F)(F)F)C=C2C)C1 CC1=CC=C(C(=O)N[C@@H1]2COC[C@@H1]2NC(=O)[C@@H1]3C[C@H1]3C4=CN=CC=C4C)C=C1C COC1=CC=CC=C1C(=O)C(=O)NC[C@@H1]2C[C@H1]2CNC(=O)[C@H1]3CCN(C)C(=O)C3 C[C@@H1](CNC(=O)[C@]12CSC[C@@H1]1C2)CN(C)C(=O)C3=CC=C4C(=C3)CNC4=O CCOCCCCC(=O)N1C[C@H1]2[C@@H1](N(C)C(=O)C[C@@H1]3CCC[C@@H1]3C)CCC[C@H1]2C1 C[C@@H1]1C[C@H1](C(=O)N2CC[C@@]3(CCN(C(=O)C4=CC(C#N)=C(O)N=C4N)C3)C2)CO1 CCC(CC)C(=O)N[C@H1]1C[C@H1]2C[C@H1]1CN2C(=O)C3=CC=C(C4=CC=CO4)N=C3C CC=1C=NN(C)C=1C(=O)NC[C@H1](CO)NC(=O)C2=CC=CC3=C2C=CN3CCO COC1=CC=C2C(=C1)[C@@H1](C(=O)NCC3(NC(=O)C4=CC=C(O)C=C4F)CC3)CC2 CCC1=CC=C(NC(=O)C2=CC=CN=C2C3=CC=CC(C(C)C)=C3F)C=C1Cl CC(C)C[C@@H1](CNC(=O)C[C@H1]1COC(=O)N1)NC(=O)C(C)(C)C2CCC2 C[C@@H1](CCNC(=O)C1=NN(C)C=C1N)NC(=O)C2=CC=C(OCCF)C=N2 CCO[C@H1](C)C(=O)N1CC=C[C@@]1(C)C(=O)N2CCC[C@H1](CN(C)C)C2 C[C@@H1](CNC(=O)C(C)(C)C1=CCSCC1)NC(=O)C2=NO[C@@H1](C(C)(C)C)C2 COC(=O)[C@]1(C(=O)NCCCNC(=O)C=CC2=CC=C([C@H1]3C[C@@H1]3C)O2)C=CCC1 CCOCC[C@@H1](C)NC(=O)[C@@H1](CN1C=CN=N1)NC(=O)CN2C=NN=N2 CO[C@H1](C)CCC(=O)N1C[C@H1](C(F)F)[C@@H1](NC(=O)C2=CCC(C)(C)CC2)C1 C[C@](O)(CC(=O)N[C@@H1]1CN(C(=O)[C@H1]2C[C@H1](O)C2)[C@]3(CCOC3)C1)C4CC4 C[C@H1](CCC(=O)NCC=1C=C(C(=O)N2C[C@@H1](O)CC23CCC3)ON=1)N(C)C CN1C=NC(C(=O)N[C@H1](C(=O)N2CCSC[C@H1]2C)C3=CC=CO3)=N1 CC(C)C1=NC(NCCCN2C=CN=C2)=CC(=NCC3=CN=C(C(F)F)S3)[NH1]1 O=C(COC(=O)C1=CC=C(Br)C2=CC=CC=C12)N[C@H1](C3=CC=CC(F)=C3)C(F)(F)F C[C@@H1](CC(N)=O)C(=O)N1CCC[C@]1(C)CNC(=O)C2=CSC3=C(O)C=CN=C23 CN=C1[NH1]C(=NCCN2CCCOCC2)[NH1]C(=N[C@H1](C)[C@H1](C)COC)[NH1]1 COC1=CC=NC=C1C(=O)NCC2(O)CC(C(=O)N3CCC(CCO)CC3)C2 CC1=CC=CC=NC(C(=O)N2C[C@@H1](NC(=O)[C@@H1]3CCC(=O)N3C)CC[C@@H1](O)C2)=C1 CN1C=NC(C(=O)N[C@@H1]2CCC[C@H1](N3C=C(C4(C)CSC4)N=N3)C2)=N1 CN1N=CC=C1CCC(=O)NC23CC(NC(=O)COC4=CC=CC(Cl)=C4Cl)(C2)C3 CC(C)[C@H1]1CC[C@H1](C(=O)NCC=2C=C(C(=O)N3C[C@@H1]4C[C@H1]4C3)N(C)N=2)CC1 CCN1C=CN=C1C(=O)N2CCC3(CC2)CC(NC(=O)C4=N[NH1]C(C)=C4O)C3 C#CC[C@@H1](O)C(=O)N[C@H1]1C[C@H1]1NC(=O)C23C4C5C2C6C3C4C56C C=CCN=C1[NH1]C=C(C(=O)N2C[C@H1](CNC(=O)CCCN3CCCC3)C[C@@H1]2C)S1 CCN1N=NC=C1C(=O)N[C@@H1]2CCCC[C@H1]2NC(=O)C3=CC(O)=CC(O)=C3 CC=CCC(=O)N[C@@H1]1C[C@@H1]1CNC(=O)C=CN=C(C2=CC=CC=C2)Br CSC[C@H1](C)C(=O)N[C@H1]1CC[C@H1]1NC(=O)CCCN(C)C CCC[C@](C)(CC)NC(=O)C1=CC=CC=C1CN2C=C(CCC3CCC3)N=N2 COCCN(CC(=O)N(C)[C@H1]1CCN(C)C1=O)C(=O)CCCN2C=CC=N2 C[C@@H1]1COCC[C@@H1]1CNC(=O)C2(F)CN(C(=O)C=3C=NN4C=CC(Cl)=C(F)C=34)C2 CC(=O)NC1=CN=C(C)C(C(=O)NC(C)(C)CCCNC(=O)C(=O)N(C)C)=C1 CCOC1=CN=C(C(=O)NCC2[C@H1]3CN(CC4=CC(Br)=C(C)C=C4F)C[C@H1]23)C=N1 CC[C@@H1](O)C(=O)N1CCC(C)(C)[C@H1]1CC(=O)N[C@H1](C)COC(F)(F)F C[C@H1](C(=O)N1C[C@H1]2C[C@@H1](C1)[C@H1](NC(=O)CC=3C=CON=3)C2)C4=CC=CC(F)=C4 CCCN(CCNC(=O)C1=CC(OC)=C(Cl)C=C1Cl)C(=O)[C@@H1](C(C)C)N(C)C CC(C)=C(C)C(=O)N1C[C@H1]2[C@H1](NC(=O)[C@@H1]3CCCN3N=O)[C@H1]2C1 CC1=CC(CCC(=O)N[C@@]23CCCC[C@@H1]2CN(C(=O)/C(F)=C/CCF)C3)=NN1C C=C[C@@H1]1C[C@H1]1C(=O)N(C)CCN(C)C(=O)CCN2C(=O)OC3=CC(Cl)=CC=C32 CO[C@@H1]1CN(S(=O)(=O)C2=CN=C(N(C)CC3=NC=C(Br)S3)C(Cl)=C2)CC14CC4 C[C@@H1](CC(=O)N1C[C@@H1]2C[C@H1](C1)CN(C(=O)[C@]34CSC[C@H1]3C4)C2)C(F)(F)F CC(C)[C@@H1]1CN(C(=O)C2(C)CC2)CCN1C(=O)/C=C/C3=CN=C(C(C)(C)C)S3 C[C@H1](O)C(F)(F)C(=O)N[C@H1]1CO[C@H1]2CN(C(=O)C3=CC=NC=C3O)C[C@@H1]12 CN(C[C@H1]1CCN(C(=O)COC2=CC(F)=CC(F)=C2)C1)C(=O)COC3CCCC3 C#CC1=CC=C(CC(=O)N2CC[C@@H1](NC(=O)CC(=C)Br)[C@@H1](CC)C2)C=C1 C=CC(C)(C)CC(=O)N[C@@H1]1CCN(C(=O)C2=CC(Cl)=CC=C2C)[C@H1](C3CC3)C1 CCN(C[C@@H1](C)NC(=O)CC12CCC(CC1)C2)C(=O)[C@H1]3CC4(CCCC4)CO3 CN(C[C@H1]1CCCN(C(=O)CN2CCSCC2)C1)C(=O)C3=C(N)C=C(Cl)C=C3Cl CC[C@H1](CNC(=O)CC1=CN=CN1C)NC(=O)[C@H1](C)NC(=O)CC(F)(F)F C[C@@H1]1OCCC[C@@H1]1C(=O)N(C)[C@@H1]2CN(C(=O)CCS(=O)(=O)N(C)C)C[C@H1]2O C=CC[C@H1](C(=O)N[C@]1(C)CCN(C(=O)[C@@H1](C)CC2=CC=C(OC)C=C2)C1)N(C)C NC=1SN=NC=1C(=O)N2C[C@@H1](C(=O)N[C@H1]3CC[C@H1]4CCC[C@@H1]3O4)C[C@@H1](F)C2 CCCCCCCCC(=O)NC[C@H1]1CCCN(C(=O)C(C)(C)NS(C)(=O)=O)C1 C[C@](O1)CN([C@@H1](C(=O)NCC2=CC=CC(Br)=C2)C3=CC4=C(Cl)C=CC=C4S3)CC[C@H1]1C COCC[C@@H1](OC)C(=O)N[C@H1]1CC[C@H1](NC(=O)C2=CC=CC=3[NH1]C=C(Cl)C2=3)CC1 CCC1(C(=O)NCCC2CC(C(=O)N(C)C3CC4(CC4)C3)C2)CC(C)(C)C1 CN(C)C1(C)CCC(NC(=O)[C@H1]2CCNC2=O)CC1 C/C=C/C[C@H1](NC(=O)[C@H1]1C[C@@H1](N(C)C)C1)C(=O)N2CCN(OCC)C2 COC1(CO)CN(S(=O)(=O)C2=CN=C(N(C)C[C@@H1](F)Br)C(C#N)=C2)C1 COC(=O)N1CCN(C(=O)[C@]2(NC(=O)C3=CC(O)=CC(=O)O3)CC2(C)C)CC1 CC(C)N1C[C@@H1]2CC[C@H1](C1)N2C(=O)C(=O)N(C)CCC3=CC=C(Cl)S3 CC[C@H1](CCC(=O)N1CCC[C@@](O)(C(C)C)C1)NC(=O)C2=CC(C3CC3)=NO2 CC1=CC(C)=CC(CC(=O)N[C@H1]2C[C@H1]2NC(=O)C3=CN=C4C=CC(F)=CN34)=C1 CC1=NC(CC(=O)N[C@H1]2CC[C@@H1](O)CN(C(=O)C3=CN4C=CSC4=N3)C2)=C(C)S1 CC[C@H1](C)[C@@H1](O)C(=O)N[C@@H1](C)C1CN(C(=O)C2(C(N)=O)CCC2)C1 COC(=O)C1=CC(C(F)(F)F)=CC=C1NC(=O)[C@@H1]2C[C@H1]2C(=O)NC[C@H1]3CCOC3 O=C(N[C@@H1]1CCCN(C(=O)C=2C=NON=2)CC1)C3=CC(Cl)=CN=C3F COCCO[C@@H1](C)C(=O)N1CCC2(CCN(C(=O)C34CC(C)(CO3)C4)CC2)CC1 CCC[C@@H1](OCC)C(=O)NC[C@](C)(CC)NC(=O)C(=O)NC1=CC=C(C)C(C)=C1 CO[C@H1]1CC[C@@H1](C(=O)N2CC[C@@](CF)(C(=O)NCC3(C(C)(F)F)CC3)C2)CC1 O=C(CC1=CC=C2OC=CC2=C1)NCC3(NC(=O)CCCCC4CC4)CC3 CSC[C@](C)(NC(=O)C1=C[NH1]C(=O)C=N1)C(=O)N[C@@H1](C)C=2C=CSC=2 COCC1=NC=C(NC(=O)[C@H1]2CN(C(=O)C3(C)CCC(C)CC3)CCO2)C=N1 C=CCC(=O)N1CC2(CO[C@@H1](CNC(=O)CC3=C(F)C=NC=C3Cl)C2)C1 CCN1CCC[C@H1](NC(=O)[C@](C)(O)C2=CC=CC3=CC=CC=C23)C1 NC(=O)C1=COC(CNC(=O)C2=CC=C(C(F)(F)C(F)(F)F)C=N2)=C1 COC1(CCNC(=O)C2=COC=C2C)CN(C(=O)[C@@H1]3C[C@]3(C)C(F)F)C1 O=C(C1=CC([N+1](=O)[O-1])=CS1)N2[C@H1]3CN(CC4=CC=CN5C=CN=C45)C[C@H1]32 C[C@@H1](OC[C@H1]1CCCCO1)C(=O)N(C)CCC2=CN(CC(C)(C)C)N=N2 C#CC[C@H1](CC(F)F)C(=O)N1CC(F)(F)C[C@H1]1C(=O)N[C@@H1]2CCN(C)C[C@@H1]2C#N C=C[C@](C)(CCOC)C(=O)N[C@@H1]1CC[C@@H1]1CNC(=O)C2=CN(C3CCCC3)N=N2 C=C(CNC(=O)[C@@H1](CC=1C=COC=1)NC(=O)C2=CN=C(C3CC3)O2)C(F)(F)F COC=1C=C(C(=O)NCC2=CC=C(CNC(=O)C3=C[C@H1]4CCC[C@@H1]34)C(F)=C2)[NH1]N=1 CC[C@H1](CC(=O)N[C@@]1(CO)C[C@H1]2CC[C@H1]1C2)NC(=O)C3=CC=NN=C3O CC[C@H1](C)NC(=O)[C@H1](C1=CC=C([S@](C)=O)C=C1)N2CCC[C@@H1](CO)C2 C[C@H1](NS(C)(=O)=O)C(=O)N[C@@H1]1CN(C(=O)CCCC#CC2=CC=CC=C2)C[C@@H1]1C C[C@@H1]1CN(C(=O)[C@]2(C#N)CCOC2)CC[C@H1]1NC(=O)/C=C/C3=CC=C(Cl)C=C3F CCS[C@H1](C)C(=O)N1CCN(C(=O)C2=CN=CC3=CC=CC=C23)[C@@H1](CC4CC4)C1 C[C@@H1]1C[C@H1]1CCC(=O)N2C[C@H1](NC(=O)CC3=CC=CC4=C3CCC4)C5(CCC5)C2 COCCOCC=CC(=O)N1CC[C@@H1](C(=O)NCC2=NC=C(C)C=N2)C(C)(C)C1 CC(C)=CCCC(=O)N1CC[C@H1](CCNC(=O)C(F)(F)C2=CN=CC=N2)C[C@H1]1C CCSC1=CC=CC(C(=O)N2CCO[C@H1]([C@@H1](C)NC(=O)C3(O)CC3)C2)=C1 CC(C)(C)C1=CSC(NC(=O)C2=CC=C(C3=CCSCC3)N=N2)=N1 O=C(CCCF)N[C@H1]1C=CCN(C(=O)C#C[C@H1]2CCCOC2)C1 CC1=CN=C(C(=O)NC[C@@H1]2CCCN(C)[C@@H1]2C=3C=NN(C)C=3C)C=C1Cl CC1=C[NH1]C(C(=O)NCC2=CC=C(CCNC(=O)C(C3CC3)C4CC4)C=C2)=C1 C=CCCC[C@H1](NC(=O)[C@H1]1CCCSC1)C(=O)N2CC[C@H1]3CC[C@H1]32 CCC(C)(C)C1=CC=CC=C1C(=O)N[C@@H1]2CC23CCN(C(=O)C4CC4(F)F)CC3 COC=1C=C(C(=O)N2C[C@@H1](O)[C@H1](NC(=O)C[C@@]3(C)CCCO3)C2)N(C)N=1 CCC1=CC=CC(C(=O)NC[C@@H1](C)N(CC)C(=O)CC2=CN(C(C)C)N=N2)=N1 CCC(=O)N[C@@H1]1CC2(CCN(C(=O)[C@@H1](CC)NC(C)=O)CC2)C3=CC=CC=C31 C=CCSCC(=O)N[C@H1]1C[C@H1](CNC(=O)C2=NC(O)=C(C)S2)C1(C)C COC=1SC=CC=1C(=O)N[C@H1](CNC(=O)[C@H1](C)C(C)(F)F)C23CCC(CC2)C3 CO[C@@]1(C)CCN(C(=O)C2=CC=C(Cl)N=C2NC(=O)[C@H1]3CCNC(=O)C3)C1 CC(C)N1C=C2C(=N1)[C@@H1](NCC3=NC=CC=C3)C4=NC=NN4C2 CC1=CC=CC(C(=O)N(CCO)[C@H1]2CCCN(C(=O)CC[C@@H1]3C[C@H1]3C)C2)=C1 CCCC[C@H1](NC(=O)C(C)=C1CCCC1)C(=O)NCCCS(N)(=O)=O CCC[C@H1](C)C(=O)N1CCN(C(=O)C2=CC=C(C#N)[NH1]2)C[C@@H1]1CCO CC(C)(F)CC(=O)N[C@@H1]1CCN(C(=O)[C@H1]2CC3=CC=CC=C3C(=O)O2)C14CC4 CN(C)[C@@H1](CO)C(=O)NC1(CNC(=O)C2=CSC(C(F)(F)F)=C2)CCCCCC1 COC1=CC=C(Cl)C(NC(=O)[C@@H1]2CCN2C(=O)C=CC3=CC=C(C(=O)OC)O3)=N1 CCC(CC)(CNC(=O)C1(O)CC1)NC(=O)C2=CC=CC=C2COC CC1=NN(CC(=O)N[C@H1]2CCN(C(=O)[C@]3(C(F)F)CC3(F)F)C[C@@H1]2F)C(=O)O1 C[C@H1](CCCC(=O)NC[C@]12CCC[C@H1]1C2)NC(=O)C3=CC=4OC=CC=4[NH1]3 O=C(N[C@@H1]1C[C@@H1](NCC2=CC=CC(Br)=N2)C[C@H1]1O)C3=CC=CC(F)=N3 COC[C@@]12CO[C@@](CN=C3[NH1]C4=CC=CN=C4S3)(C1)C2 C[C@@H1](C(=O)NC1CC1)N2CCN(C(=O)CCC3=CN=C(C4CCC4)O3)CC2 C=CC(C)(C)C(=O)N1C[C@H1]2[C@H1](CNC(=O)C3=CN4C=CC=CC4=N3)CC[C@H1]2C1 CCC1=NC=C(C(=O)N2C3[C@H1]CC[C@H1](NC(=O)C4=CC=C(Cl)N=C4OC)[C@H1]3C2)[NH1]1 C[C@@H1]1CCCN(C(=O)COC(C)(C)CNC(=O)CC2CCOCC2)CC1 CNC(=O)C1=CN=CC(NC(=O)N2CCN(CCOC(C)C)CC2)=C1 C=CCC(C)(C)C(=O)NC[C@]1(C)CC[C@@H1](NC(=O)C2=CC=C(NC(C)=O)C=C2)C1 CCCC=C[C@H1](O)C(=O)N1CC[C@@](C)(NC(=O)[C@@H1]2CCC(=O)N(CC)C2)C1 CC=1C=C(C)N(C2=CC=C(Cl)C(C(=O)N3CC=C(C4=CC=CN=C4)C3)=N2)N=1 COC1=CSC(NC(=O)[C@H1]2C[C@@]23CCN(CC4=CC=NC(Cl)=C4Cl)C3)=C1 CCN1CCC2=C(SC(NC(=O)[C@H1]3COCCC3(F)F)=C2C(=O)OCC)C1 CC(C)N1C=NC(C(=O)N[C@H1](CNC(=O)CCC(F)(F)F)CC(F)(F)F)=N1 CC1=CC=CC(C(=O)C(=O)N[C@]23CC[C@H1]2CN(C(=O)C[C@H1]4C=NN(C)C4=O)C3)=C1 C[C@H1]1CSCCN1S(=O)(=O)C2=CC=C(NC3CC(C4CCCC4)C3)C(Cl)=C2 CC[C@H1](CC(=O)N[C@H1]1COCCN(C(=O)C=2N=NN3C=2CCC3)C1)SC CC[C@H1](C)C(=O)N(C)[C@@H1]1CCC[C@H1]2CN(C(=O)C3=CC(C(F)F)=NN3C)C[C@@H1]21 O=CC1=C[C@@H1](C(=O)N[C@H1]2CCC23CCN(CC4=CC(B(O)O)=CC=C4F)CC3)N=N1 CN1C(=O)CC[C@@H1]1C(=O)N2[C@@H1]3C[C@H1](F)[C@H1](C3)[C@H1]2C(=O)NC4=CC=C(F)C(CO)=C4 C=C1CCN(C(=O)C=2C=COC=2)[C@H1](C(=O)N3CC(OCC)C3)C1 CC(C)(F)CCC(=O)N[C@@H1]1CN(C(=O)C2=CC=CC(S(=O)(=O)CF)=C2)CC13CC3 O=C(C=C(Cl)Cl)N1CC[C@@H1]2CCN(C(=O)C3=CC=NN3CC(F)F)C[C@@H1]2C1 COC[C@@H1](NC(=O)[C@@H1](CN(C)C)NC(=O)C=1C=CN(C)C=1C)C(=O)OC O=C(C1CSC1)N2CC[C@H1]3CCC[C@]32C(=O)NCCC4=CC=NC=C4F CSC1=CC=C(C(=O)N2CC[C@H1](CNC(=O)C3=C[NH1]C(Br)=C3)C2)O1 CCC1=CC=C(NC(=O)[C@@H1](CNC(=O)CS(=O)(=O)NC)CC(C)C)C=C1 N=C1[NH1]C2=CC(C(=O)N[C@@H1]3C[C@@H1]3NC(=O)CC4=CC=CO4)=CC=C2S1 C[C@@H1]1CCCN(C(=O)CCOCCNC(=O)C2=CN=C3C=C[NH1]C3=C2)[C@@H1]1CO CC1=NC2=CN=CC(C(=O)NC[C@@H1](C)CNC(=O)[C@@H1](O)CC(C)(C)C)=C2[NH1]1 COC1=CC(CN2CC(NC(=O)C3=CC(Cl)=NC=C3F)C2)=CC=C1I CCN1N=CN=C1C(=O)N[C@H1](CCN(C)C(=O)C2=CN=C(C(C)(C)C)S2)C(C)C CC(=CC(=O)NCC12CC(CN1C(=O)[C@H1]3CCCC=4N=C[NH1]C=43)C2)C(F)F CC(C)=CCC(=O)N[C@@H1]1C[C@H1]1CNC(=O)C2=C(C#N)C=NN2C N#CC[C@H1]1CN(C2=NC=C3[NH1]C=C(I)C3=N2)CCN1C(=O)C4=CC(=O)C=CO4 C[C@@H1](CNC(=O)C1=CN=C(C(F)F)S1)N2C=C(C3=CC=CC=4SC=CC3=4)N=N2 COC1=CC=C2C=C(C(=O)NCC3=CC(C#N)=CC=C3[N+1](=O)[O-1])C=CC2=C1 CC1(NC(=O)[C@H1](C2=COC(Br)=N2)N3CCC(SC4=CC=C(Cl)C=C4)CC3)CC1 CCN(CC)CCSCC(=O)N[C@@H1]1[C@H1]2C[C@H1](NC(=O)[C@@H1](C)[C@H1](O)C(C)C)C[C@H1]21 CN1CCCC[C@H1]1CC(=O)NCC[C@@H1](O)CNC(=O)C2=C[C@H1]3C[C@@H1](C2)C[C@@H1](C)C3 C[C@H1](C(=O)NC1(C2=CC=CC=C2F)CC1)C3=CC=CC(Br)=N3 CN1CC[C@H1](CN(C)C2=NC(N(C)CC3=NC=C(Cl)N3C)=NC4=C2CSC4)C1 C=C1CC(C(=O)N[C@H1]2C[C@@H1](NC(=O)CN3C=C([N+1](=O)[O-1])C=N3)C2)C1 CCC1=CC(C(=O)N2CC=C[C@@H1](C(=O)N3C[C@H1](O)C4(CCCC4)C3)C2)=CC=N1 CN(C)CCOCCN(C)C1=NC2=C(C(=NC[C@@H1]3CCCCN3C)[NH1]1)COCC2 CC(C)S[C@H1](C)C(=O)N[C@@H1]1COC2(C1)CN(C(=O)CCCN=C3N=CC=C[NH1]3)C2 C=CCOCCNC(=O)[C@H1]1C[C@H1]2C[C@H1]1CN(C(=O)C3=CC=CC(OCC)=C3)C2 COC[C@H1](C)CC(=O)N(CCO)C1CCN(C(=O)[C@@H1]2CCCC23CC3)CC1 CC[C@H1](C(=O)NC[C@@H1](C)N(CC)C(=O)CC1=CC=C(C)C=C1)N2CCCC2=O C[C@H1](C1CC1)[C@H1](C(=O)NCCOCC2=CC=CC=C2)N3CCCC[C@](C)(F)C3 C=CC[C@H1](CC)C(=O)N1CCC(C)(NC(=O)C[C@H1]2CCCC3=CC=CC=C32)CC1 C=CC1(C(=O)N2C[C@H1]3C[C@@H1](NC(=O)C4=NOC5=CC=C(Cl)C=C45)C[C@H1]2C3)CCC1 CC1=CC(Cl)=C(C(=O)N[C@@H1]2CCN(C(=O)C3=CC=C(C(F)(F)F)O3)[C@H1]2C4CC4)S1 CC1=NN(C)C(=O)[C@H1]1CC(=O)N[C@H1]2C[C@](F)(CNC(=O)[C@H1](C)C3=CC=CC=C3)C2 CN(C[C@@H1]1CN(C(=O)[C@@]2(C)CCCS2)CC13CC3)C(=O)C4=CC(Cl)=NC=C4O C#CC1=CC(F)=CC(C(=O)NC2(C(=O)OC)CCC(C)(C)CC2)=C1 C[C@@H1](SC1=CC=C(F)C=C1)C(=O)NCC2CCN(C(=O)CNS(C)(=O)=O)CC2 C#C[C@H1]1C[C@H1]1C(=O)N2CC(F)(F)C[C@@H1]2CNC(=O)C3=CN=C(C4=CC=CC=N4)S3 O=C(C1=C(F)C=CC=C1NCC2=CC=C(I)C=C2O)N3CC[C@@H1](Br)C3 C#C[C@@]1(C(=O)NC[C@H1]2C[C@@H1](C(=O)OC)C2)CCN(C(=O)[C@H1](C)S(C)(=O)=O)C1 CCOC1=CN=C(C(=O)NC[C@@H1]2CCCN2CC3=CC=CN=C3Cl)C=N1 CCCN1N=NN=C1[C@](C)(CC[C@@H1]2CCCCO2)NCC3=CC=C(C)N=C3CC O=C(N[C@@H1]1C=CCN(C(=O)C2=C(Br)C=NN2C)C1)C3=CC(O)=CC(Cl)=C3 C#C[C@H1]1[C@H1](C(=O)N2CCN(C(=O)CC(C(C)C)C(C)C)[C@@H1](C)C2)C1(C)C C=C(Cl)CCC(=O)NCC(C)(C)C(=O)N1CCC[C@@H1]2C[C@H1]21 CCC1=CC(N)=CC=C1C(=O)N2C[C@H1](NC(=O)[C@H1]3CCCO3)[C@H1](OC)C2 C=C(C)CN1N=NN=C1[C@H1](NC2CC(C(N)=O)C2)C3=CC(Br)=CC=C3F CCC(CC)(CC)C(=O)NC[C@@H1]1CCN(C(=O)C#CC2CC2)C[C@@H1]1O C[C@@H1]1CCC[C@H1]1C(=O)NC(C)(C)CN(C)C(=O)C=2OC=NC=2C3CCC3 CCCCCOC1CN(C(=O)[C@H1](CN2C=NC=N2)NC(=O)[C@H1](CC)NC(C)=O)C1 O=C(CC1=COC2=CC=C(F)C=C12)NCCCCCNC(=O)[C@H1]3CC[C@@H1](F)C3 CCN1C=C(C(=O)NC(C)(C)CCCNC(=O)C[C@H1]2CC[C@H1](C)C2)C=N1 CCN(CC)CCC(=O)N1CC[C@H1]2CC[C@]21CNC(=O)C3=CC=CC(=O)O3 NC(=O)[C@@H1]1[C@@H1]2CCN(C(=O)CCCC3(NC(=O)CN4CCOC4=O)CCC3)C[C@H1]21 CC1(CCN[C@](C2=NN=NN2C3CC3)CCC(=O)N(C4=CC=CC=C4)C)CC1 O=C(CCC1=CC=C([N+1](=O)[O-1])C=C1)N2CC(O)([C@@H1]3CCCN3C(=O)COCCO)C2 COC(=O)[C@]1(CCCN2CCN(CC(=O)N[C@@H1]3CCCC[C@H1]3C)CC2)CC1(F)F CCOC1(CNC(=O)C2(CCNC(=O)[C@H1]3CCCC[C@H1]3F)CCCC2)CCC1 CC1=NC=C(CCC(=O)NC2(C)CN(C(=O)C3=CSC(C(F)(F)F)=N3)C2)S1 C#CCOCC(=O)NC[C@@H1](C)[C@@H1](F)C(=O)N1CC[C@@](F)(CO)C1 O=C(NCC1=NN=NN1C2CC2)[C@@H1]3C=CCCN3C(=O)C4=CC(Cl)=NO4 O=C(CC(=O)N[C@H1]1C[C@H1]2C[C@@H1](C1)N(C(=O)C3=C[C@@]4(CCOC4)C3)C2)NCC5CC5 COC1=CC(Br)=CC(F)=C1C(=O)N2CC[C@@](O)(C(=O)N=C3C=C[NH1][NH1]3)C2 CNC(=O)N[C@@H1](C)C(=O)N[C@@H1]1CCCN(C(=O)C2=CC=C(Cl)C(C)=C2O)C1 CC=1SC=CC=1C(=O)NCC2CC3(C2)CN(C(=O)[C@@]4(C)CCC5=CC=CC=C54)C3 CC1=CC=C(C(=O)N2CC[C@](C#N)(NC(=O)C3=CN=C(Cl)C(F)=C3)C2)C=C1Cl O=C(C=CC1=CC=CO1)NCC=2N=COC=2CCNC(=O)C3=N[NH1]C=C3Cl CC=1N=C[NH1]C=1C(=O)N(C)CCCCCNC(=O)[C@@]2(C(F)(F)F)OC3CCC2CC3 CCCC1=CN=C(N2CC[C@H1](CC(=O)N(C)CC(C)(C)CO)C2)N=C1 CS[C@@H1](C)CC(=O)N1CC[C@@](CF)(C(=O)NC[C@H1]2COC[C@H1](C)O2)C1 CO[C@@H1]1CN(C(=O)CC2=CN=C(C)O2)[C@](C)(CNC(=O)C3=CC=C(Cl)C=C3C)C1 CCN1N=CC=C1C(=O)N2CCOC[C@H1]2C(=O)N3CC[C@]4(CCCO4)C3 CC(C)C1=CC=NC(N(CC2CCNCC2)C(=O)C=3C=C(CO)ON=3)=N1 COC(=O)C1=C(Cl)C=CC=C1S(=O)(=O)NC(=O)C2(CC3=CC=C(F)C=C3)CCC2 CC1=CC=C(C(=O)N2CCN(C)C[C@H1]2CNC(=O)C=3C=NN4C=3CCC4)C(O)=C1 C[C@H1](CCNC(=O)C1=N[NH1]C(C2CC2)=C1Cl)NC(=O)[C@@H1]3CC(C4CCOCC4)=NO3 CC1=CC=C(COCC(=O)N2C[C@H1]3CC[C@H1]2CN3C(=O)C4=C[C@]5(CCOC5)C4)S1 C[C@H1]1O[C@H1]2CC[C@@]1(C(=O)N[C@@H1](CC(=O)N[C@@H1]3COC(=O)C3)C(F)(F)F)C2 CNC(=O)C1=CC=C(C2=CC=C(NC(=O)C3=CC4=CC(C)=CC=C4[NH1]3)N=C2)C=N1 CC1=C(C(=O)N[C@H1]2CC[C@H1](C(=O)NCC3(O)CCC3)C2)C=CC=C1[N+1](=O)[O-1] C[C@H1](CCC(C)(C)C)C(=O)NCCN(C(=O)C1=NO[C@H1](C2(O)COC2)C1)C3CC3 C#CCN(CCCO)C(=O)[C@H1](NC(=O)CN(C)C(C)=O)C1=CC=CN=C1 C=C=CCCC(=O)NC[C@H1]1CCCCN(C(=O)CC(=O)OCC)C1 O=C(C[C@@H1]1C=CCC1)NCC[C@H1]2CCCCN2C(=O)[C@H1]3C[C@@H1](N4CCOCC4)C3 CNC(=O)/C(C)=C/COC(=O)C[C@@H1](C1=NC=CN1C)C(F)(F)F C=C(Cl)C[C@H1](NC(=O)C1=COC2=CC=CC=C12)C(=O)NOCC=3N=C[NH1]N=3 CC(C)(CO)CNC(=O)[C@@H1]1CC12CCN(C(=O)CSC(F)F)CC2 CC(=O)C1=CC=C(C)C(NC(=O)C2=C(Cl)C(C)=NN2C)=C1 CN(C)C[C@H1](O)CC(=O)N1CCCC(C)(C)[C@H1]1C(=O)N2CCN(C)C[C@H1]2C CCN(C)CC=CC(=O)NC[C@@]1(CNC(=O)[C@@H1]2CCC[C@H1](C#N)C2)CC13CCC3 O=C(NCC1CN(C(=O)C2(N3N=CC=N3)CC2)C1)[C@@H1]4CCCN4C5CCCCC5 O=C(CCN1CCCCC1)NCC(=O)NC2=CN=C3[NH1]C=NC3=C2 CC1=CC(C(=O)N[C@@H1]2CN(C3=NC(C4CCCC4)=NS3)CC5=NC=CN5C2)=NS1 CCCCCCCCCCC(=O)N[C@@H1]1CCN(C(=O)[C@@H1](C(C)C)N2C=NC=N2)C1 C=C1C[C@H1]1C(=O)N2CC3(CN(C(=O)CN4CCS(=O)CC4)CCO3)C2 CCCOCC(=O)N(C)[C@@H1](CNC(=O)C1=CC=CC(C(F)(F)F)=C1O)C2CC2 O=CCC1N(C(=O)C2=CN(C3=CC=CC(F)=C3)N=N2)[C@H1]4CCCC[C@H1]14 C[C@@H1]1CN2CCN1[C@H1](C(=O)N3[C@@H1]4CCN(C(=O)COC(=O)CO)C[C@@H1]4C[C@H1]3C)C2 COC1=CC=C(C(=O)N2CCC[C@H1](C(=O)N3CCC[C@@H1](O)[C@@H1]3C)CC2)C(C)=C1 CC[C@H1]1CCN(C(=O)C2=CN=C(N)C=N2)[C@@H1]1C(=O)NC3CN(C4=NC=CO4)C3 CN(C)[C@H1](CCC(N)=O)C(=O)NC[C@@H1](NC(=O)C(C)(C)C(F)F)C1CCC1 COCC[C@@H1]1CN(C(=O)C[C@H1]2CC=C[C@H1]2O)CCN1C(=O)C=3ON=C4C=CC=CC=34 CN(C)CCOCC(=O)N1CC(N(C)C(=O)C2=C(Br)N=NN2C3CCC3)C1 CCS[C@@H1](C)C(=O)NC1[C@H1]2COC[C@H1]1CN(C(=O)C=3C=C(C)N(C)C(=O)C=3)C2 C[C@H1](O)[C@@H1](NC(=O)C1CC1)C(=O)N(C)C[C@H1]2CCN(C(=O)C3=NC(Cl)=C(Cl)S3)C2 CC1=C(C(=O)N2C[C@H1]3C[C@@H1](C2)[C@H1](C(=O)N4CCN5C=NN=C5C4)C3)CC1 CN(CC(C)(C)C)S(=O)(=O)C1=CC=CC(=NC[C@H1]2C(C)(C)C2(F)F)[NH1]1 CCC1=CN=C([C@@H1](NC2=CC(Cl)=C(F)C(Cl)=C2)C3=NN=NN3C4COC4)[NH1]1 CC=C1C(O)=NC(C(=O)N2CCC[C@](O)(CN(C)C(=O)C3CC4(CCC4=O)C3)C2)=C1 COC1=CC=CN=C1C(=O)NC[C@@H1](C)CNC(=O)C2=CC=C(Cl)C=C2F C/C=C/C[C@@H1](NC(=O)C[C@H1](C)N(C)C)C(=O)NC1=CC=C(CC)C=C1 CN(C[C@@H1]1CCCCN1C(=O)[C@H1]2OCC2(C)C)C3=CC(C(N)=O)=NC(Cl)=N3 CN(CC(C)(C)CNC(=O)C1C2CCC1CC2)C(=O)[C@H1]3C[C@@H1]3C(C)(C)C CN(C[C@@H1](O)C1CCC1)C(=O)C(=O)C(C)(C)C COC1=CC(C(=O)N2CCCC[C@H1](NC(=O)CC3=CC=C(F)C=C3C)C2)=NN1C CN(C(=O)CCSC1CCCC1)[C@@H1]2CCN(C(=O)[C@@H1]3CN4CCC3(C)CC4)C2 C#C[C@H1](C)NC(=O)C[C@@H1]1CC2(CC2)CN1C(=O)CC3CC3 CC[C@H1](C)[C@H1](C(=O)NC1CCSCC1)N(C)C(=O)C2=CN(C)C=C2C CC=1N=C(CC(F)(F)F)SC=1C(=O)N[C@@H1]2CCCNC2=O CC1=CC=CC(F)=C1C(=O)NC[C@@H1]2CCN(C(=O)C3=CC=CC=C3OC(C)C)C2 CCCC(=O)N[C@H1]1C[C@@H1]2CN(C(=O)C3=CC(Cl)=CC=4C=C[NH1]C3=4)C[C@@H1]2C1 O=C(N[C@H1]1C[C@H1](NC(=O)C2=C(F)C=NC=C2Cl)C1)C3=C[C@H1]4CC[C@H1]3C4 O=C(C[C@@H1]1CCS(=O)(=O)C1)NCC2=CCN(C(=O)C[C@@H1]3CN4CCN3CC4)CC2 CC1=CC(N)=CC=C1C(=O)N2[C@H1]3CCC[C@H1]2CN(C(=O)[C@H1](C)N(C)C)C3 CCCCC1(C(=O)N[C@H1](C(=O)N[C@H1]2COC(C)(C)C2)[C@@H1]3CCOC3)CC1 C[C@H1](CNC(=O)C[C@@H1]1CCCCO1)CNC(=O)C2=CC(F)=CC(C(N)=O)=C2 CC1=CC=C(C)C(CC(=O)N2CC(O)(CCNC(=O)CN(C)C3CCC3)C2)=C1 CCN=C1[NH1]C(C)=C(C(=O)NC(C)(C)[C@@H1](C)NC(=O)CC2CCOCC2)S1 C[C@@]1(CNC(=O)C2=CC3=CC=C(Cl)C=C3C(O)=N2)C[C@H1]1Br O=C1NC[C@H1](C(=O)N[C@H1]2C[C@H1]3CC[C@H1]2N(C(=O)CCN4C=NC([N+1](=O)[O-1])=C4)C3)N1 CC1=CC(Cl)=CC(C(=O)N2C[C@@H1]3C[C@H1](NC(=O)CN4C=C([N+1](=O)[O-1])C=N4)[C@H1]3C2)=C1 CCOC(=O)C(C)(C)NC(=O)[C@]1(F)CCCN(C(=O)CCC2CC2)C1 CC(=O)N[C@H1](C(=O)N[C@@H1]1CCOC[C@@H1]1NC(=O)[C@H1]2COC3=CC=CC=C32)C(C)C CCC=1OC(C(=O)N2[C@H1]3CC[C@H1]2CC(CCNC(=O)C4=CN=CN=C4)C3)=CC=1C CC1(C)C[C@@](C)(NC(=O)C2=CCN(C(=O)[C@@](C)(O)C3CCC3)CC2)C(=O)O1 COCC1(CC(=O)N[C@@H1]2CCN(C(=O)C3=CC=CN=C3S)C[C@H1]2C(C)C)CC1 CCN(CC(C)C)[C@@H1](C(=O)NC1CCC(F)(F)CC1)C=2C=C(C)N(C)N=2 C#CC(C)(C)C(=O)NC[C@@H1](C)[C@]1(O)CCN(C(=O)C2=NN(C)C3=CC=CC=C23)C1 C=C[C@@H1]1C[C@H1]1C(=O)N(CC)CCN(CC)C(=O)[C@@H1]2CCCCN2N(C)C CC(C)N1N=CC=C1C(=O)NC[C@H1]2CCC[C@@H1]2NC(=O)C3=CC=C([N+1](=O)[O-1])S3 CCSCCC(=O)NC[C@]1(CNC(=O)C2=CC=C(OC)C=C2N)CC13CCC3 CN1C=C(C[C@H1](O)C(=O)NCCO[C@H1]2CCN(C(=O)/C(F)=C/CCF)C2)C=N1 CC(=O)SCC(=O)N1CCSC[C@@H1]1C(=O)NC2=CC(Br)=C(Cl)C=C2F CN1C=C(C(=O)N[C@@]23CCC[C@H1]2N(C(=O)CCOCC(F)(F)F)CC3)C=N1 O=C(C=CC1=CC=C[NH1]1)NCC2=CSC(C(=O)NC[C@H1]3C[C@]34CC4(F)F)=C2 O=C(CN1CCCS1(=O)=O)N[C@@H1]2CN(C(=O)C[C@H1]3CC4(CC4)CO3)C[C@H1]2C5CC5 CCC1=CC=CN=C1C(=O)N(C)[C@H1]2C[C@@H1]3CC[C@H1](C2)N3C(=O)C4=CC(F)=CS4 CC(C)(CNC(=O)COC(F)(F)F)OCCNC(=O)[C@@H1]1C[C@@H1]2CC[C@H1]1O2 CC(=O)O[C@@H1](C)C(=O)N1CCC[C@H1]1C(=O)N[C@H1]2CCC3(CCC3)C2 COC1=CSC=C1C(=O)N2CC(CCCCNC(=O)C3=CC=C(F)C(C)=C3)C2 CCN(C(=O)[C@H1](O)COC)[C@@H1]1CCN(C(=O)COC2CCCCCC2)C1 CC1=CC=CC(F)=C1C(=O)NCCN(C(=O)[C@@H1](C)[C@H1]2CCOC2)C(C)C CC[C@H1](O)[C@H1]1CCCN1C(=O)[C@H1](CCNC(=O)CCCC#N)OC CC1=CN=CN1CC(=O)N[C@H1]2CCCC[C@@]23CN(C(=O)[C@@H1](C)C4CCC4)CCO3 CC(C)(C(=O)N1CCC[C@H1](CNC(=O)C2(O)COC2)C1)C3=CN=CN=C3 CC[C@H1](C(=O)N(C)CCN1C=C([C@]2(N(C)C)CCOC2)N=N1)N3CCCC3=O COC(=CC1=CC=CC=C1)C(=O)N[C@H1]2CC[C@H1](CNC(=O)C3CC(C)(C)C3)C2 CC1=CC=C(C(=O)N[C@@]2(CO)CCN(C(=O)C34CCOC(C)(C3)C4)C2)C(F)=C1F C=C(CCNC(=O)[C@@H1](C)C1=CC=C(CC(C)C)C=C1)CNC(=O)CCCOCC CC=C1C=CC=NC=C(C(=O)NC[C@@H1]2CN(C(=O)C3=CCS(=O)(=O)C3)CCCO2)N1 CC1=C(C(=O)NCC2(C)CC(NC(=O)C3=CC=CC4=C3N=CN4C)C2)C=NN1C O=C(CCC1=CC=CC=C1F)N2CCC3(CC2)[C@@H1](NC(=O)CO)CS3(=O)=O CC(C)C[C@@H1](O)CC(=O)N1CC[C@]2(CCN(C(=O)C=C3CCN(C)CC3)C2)C1 C=C[C@@H1](C)NC(=NCC=1C=CN(C(C)C)N=1)N2CC[C@H1](C3=CC=CO3)C2 C[C@@]1(C2=CC=CC=C2)C[C@H1]1C(=O)NCC34CC(NC(=O)C5=CSC(Cl)=N5)(CO3)C4 CN1C=NC(C(=O)NC[C@H1]2CC[C@@](F)(CNC(=O)C=3C=CN(C4CC4)N=3)CC2)=N1 CC[C@@](C)(CO)C(=O)NCC[C@H1](C)NC(=O)C=1OC2=CC=CC=C2C=1C(=O)OC COC1=COC(C(=O)N2CC[C@H1](CNC(=O)C3CCN(C)CC3)C24CC4)=CC1=O O=C(N[C@@H1]1C[C@H1]2CC[C@H1]1CN2C(=O)CCOC3COC3)C4=CN(C5CC5)C=N4 CC(C)C1=CC=C(N2CCOCC2)C(C(=O)N[C@@H1](C)C3=CC=NC(Cl)=C3F)=C1 CCC=1[NH1]N=C(C(=O)N[C@@H1](CC2CC2)C(=O)N(C)CC=3SC=CC=3C)C=1C C#CCC[C@H1]1CCCN1C(=O)CCC(C)(C)NC(=O)C2=CC(O)=NC(C)=N2 CC1(NC(=O)C2=CC=CO2)CN(C(=O)[C@](C)(O)C3=CC=C(F)C=C3)C1 CC[C@H1]1CN(C(=O)[C@](C)(CC)CO)CCN1C(=O)CN2N=NC(C3CC3)=N2 CCOC[C@@H1](NC(=O)C1=CN=C(C)C=C1C)C(=O)N=C2C=CN(C(C)(C)C)[NH1]2 CC1=CC=C(C(F)F)C=C1C(=O)N[C@@H1]2CC23CC(NC(=O)[C@H1]4C[C@H1]4C)C3 CC1(C)[C@@H1](CNC(=O)[C@H1](NC(=O)[C@H1]2CC[C@H1](O)C2)C3=CC=CN=C3)[C@H1]1CO CC[C@@H1]1C[C@H1]1C(=O)N2CCN(C(=O)C3=CC=CC(C(F)F)=N3)[C@H1](C(C)C)C2 C[C@@H1](NC(=O)C12CCC(O)(CC1)CC2)C3CN(C(=O)CNC(=O)N4CCCC4)C3 C#CC1=CC=CC(C(=O)N[C@H1](C)CCCNC(=O)CCC(=O)N(C)C)=C1F CC1(C)[C@H1](C(=O)N[C@@](C)(CNC(=O)C2=NC=C(F)C=C2F)C(C)C)CCS1(=O)=O CCNC(=O)CCC(=O)N(C)C[C@@H1](O)CN(C)C(=O)[C@]1(O)CCCN(C(C)=O)C1 CC[C@H1](CC(=O)N[C@@H1](CO)CNC(=O)COC)OC COCCN1C=C(C(=O)NC2(CCO)CN(C(=O)C3(S(C)(=O)=O)CC3)C2C)C=N1 COC1=NN(C)C=C1C(=O)N2C[C@H1](NC(=O)[C@@H1]3COC[C@H1]3C(N)=O)CC4(CC4)C2 CO[C@H1](C)[C@H1](O)C(=O)NCC[C@H1]1C[C@@H1](NC(=O)CN(C)C(N)=O)C1 CC1=CC(Cl)=C(C(=O)N[C@@H1]2CCCC[C@H1]2NC(=O)[C@@H1]3CC(C4CC4)=NO3)C=C1F CN(C)C[C@H1](O)C(=O)N1CCO[C@@H1]2CN(C(=O)CNS(=O)(=O)C3CC3)C[C@@H1]21 CC12CC(NC(=O)[C@@H1]3C=CCN(C(=O)[C@@H1]4CCCN4C5CC5)C3)(C1)C2 O=C(CN1CCC(O)CC1)N2C[C@H1]3C[C@H1](NC(=O)C4=CC=CC=N4)C[C@H1]3C2 C[C@@H1](OCC1=CN(C2=CC=C(C(=O)NC3CC3)N=C2)N=N1)C(F)(F)F O=C(N[C@@H1]1CCC[C@H1](C(=O)N2C[C@]3(F)CCC[C@]3(O)C2)C1)C4=CC=NC=C4Cl COC1=CC=C(P(C)(C)=O)C=C1NC(=O)NC[C@H1]2C[C@H1]3C=C[C@H1]2CC3 C#CCCC[C@H1](C)C(=O)NC[C@@H1](CCC)C(=O)NC1(CC)CCCC1 COCCC(=O)N1CC[C@@H1](C)[C@@H1](N(C)C(=O)[C@@H1]2C[C@@H1](C)CCO2)C1 CCN1CCCC[C@H1]1C(=O)NCCCCN(C)C(=O)CCN2C(C)=CC=C2C C#CC1=CC=C(OCC(=O)N[C@H1](CC)CN(C)C(=O)C[C@H1]2CC=CCN2C)C=C1 ClC1=CC=CC(Br)=C1CN2CC[C@H1](CCN3CCC4(CCOCC4)C3)C2 CCOC1=CC=CC=C1C=CC(=O)N[C@@H1](C)CCCNC(=O)[C@@H1]2CNC(=O)N2 CN1C=C(CC(=O)N[C@@H1](CNC(=O)C2=N[NH1]C3=C2COC3)[C@H1](C)C4CC4)N=N1 COCCC[C@@H1](NC(=O)CN1N=C(C)OC1=O)C(=O)N2CCC(C)(C(C)C)CC2 CC[C@@H1](C(=O)NC[C@]12CN(C(=O)C3(O)CCSCC3)C[C@H1]1CCO2)C(C)(C)CC O=C(CN(C1CC1)S(=O)(=O)C2=CC=C(F)C(F)=C2)NC[C@@H1]3CCOC3 COCCC(C)(C)CC(=O)NC[C@@]1(C)CC[C@H1](NC(=O)C2(OC)CS(=O)(=O)C2)C1 C=C[C@H1](OC)C(=O)N[C@@H1]1CCOC[C@H1]1C(=O)NC(CC)(CC)CC CC(C)(CC(=O)N[C@@]1(C)CCCC[C@H1]1C(=O)N2CC(SC(F)F)C2)C3CC3 CCC1=NN=C(CN=C2N=C(N3CCN4C=NC=C4C3)C=C(C)[NH1]2)S1 CC=1N=C(CCC(=O)NC[C@@H1](O)C[C@@H1](NC(=O)C23CC(C)(CO2)C3)C)OC=1C CCNC(=O)C(=O)N(C)CCCN(C)C(=O)CC1=CC=C(NC(N)=O)C=C1 C=CCSCC1=NC(C[C@H1](C)OC)=NN1C2=CC=NC(O)=C2 C=C(C)CNC(=O)[C@H1]([C@@H1]1CO[C@@H1](C)C1)N2CCC[C@@H1](C)C3=CC=CC=C32 COC1=CC2=C(C=C1C(=O)NC[C@@H1](F)CNC(=O)CC(=O)NC3CC3)OCCCC2 CN1C[C@@H1](C(=O)N2CCC[C@](C)(CNC(=O)C3=CC=CC=4N=N[NH1]C3=4)C2)CC1=O C=C1CCN(C(=O)C2=CC=C3C(=C2)OCC3)[C@@H1](C(=O)NCC4=NC=CN=C4C)C1 C#CCCC(=O)N1C[C@H1](C)[C@H1](NC(=O)C2(C(C)=O)CC2)C1 CN(C)[C@H1]1C[C@@H1](CNC(=O)[C@@H1]2[C@H1]3CN(C(=O)[C@@]4(CO)CCCCO4)C[C@H1]32)C1 CN(C[C@H1]1CCN(C(=O)C=2C=CSC=2Cl)C1)C(=O)COC3(C)CCC3 CC(CO)(CO)C(=O)N1C[C@@H1](F)[C@H1](NC(=O)CCC2=CC=C(Br)C=C2)C1 CC(C)OC1=CN=CC(C(=O)N[C@@H1]2C[C@H1]3CN(C(=O)C4(O)COC4)C[C@@H1]32)=C1 CC1=NN=C(CNC(=O)[C@@H1](F)CC2CN(C(=O)[C@@H1]3C[C@H1]4C[C@@H1]3CC4=O)C2)N1C CCOC(=O)CCNC(=O)[C@H1](C1=CC=CC(Cl)=C1Cl)N2CC[C@](C)(CN(C)C)C2 N#CCCCC(=O)N1CCCCCC[C@H1]1C(=O)N2CC3(CCC(=O)N3)C2 CN(CC(=O)N[C@H1](CNC(=O)C=1C=NN(C)C=1)C(C)(C)C)CC2=CC=C(Cl)S2 COCCC1(C(=O)N2[C@H1]3CC[C@@H1]2C[C@H1](NC(=O)[C@@]4(O)CCCC(C)(C)C4)C3)CC1 C=CC[C@@H1](CNC(=O)C=1C=CC2=N[NH1]C=C2C=1)NC(=O)C3=CC(OC)=CC=[N+1]3[O-1] CC=CC=CC(=O)NC(C)(C)CN(C)C(=O)C1=CN(C)N=C1C C=CCN1C=C(C(=O)N[C@@H1]2C[C@H1]2[C@H1]3CCCN(C(=O)CC4=NN=CS4)C3)N=N1 CC[C@H1]1COCCN(S(=O)(=O)C2=CC(C)=CC(Br)=C2O)C1 CCCC1=CC(C(=O)N2CC[C@@H1]3CCN(C(=O)C=4N=C(Cl)OC=4C)C[C@@H1]32)=C(C)O1 CC1=NN=CC(C(=O)N2C[C@H1](C)C[C@H1]2C(=O)N(C)CCCOC(C)C)=C1C CC[C@H1](C#N)C(=O)NCCN(C)C(=O)[C@@H1]1[C@H1]2CC[C@@]1(C3=CN=CS3)C2 O=C([C@H1]1COCCN1C(=O)[C@H1]2C[C@@H1]3C[C@@H1]3C2)N4[C@H1]5CC[C@H1]4COC5 CC1=COC2=C(C(=O)N[C@H1]3CCN(C(=O)COCC(F)F)C3)C=CC=C12 CO[C@H1](CC(C)C)C(=O)N1C[C@@H1](F)C[C@H1]1CN(C)C(=O)C2=CC=C(Cl)C=C2[N+1](=O)[O-1] COC1=CC=NC(C(=O)N2C[C@H1](F)[C@@H1](NC(=O)C3=C(C)C=C(O)C=C3C)C2)=C1 CCOC1CC2(C1)C[C@H1]2C(=O)N[C@H1](C)CC3CN(C(=O)[C@H1]4C[C@@H1](N(C)C)C4)C3 COC=1N=C(C)SC=1C(=O)N[C@H1](C)[C@H1]2CN(C(=O)[C@H1](C)C(C)(C)C)CCO2 CC(C)OC1=CC(NC[C@H1](C)NC(=O)[C@@H1]2C[C@@]2(C)C(C)C)=CC=C1[N+1](=O)[O-1] CCCC[C@@H1](CC)C(=O)NC1(C(=O)NC[C@@H1](Cl)C(C)(F)F)CC1 CC[C@H1](C[C@H1](C)CO)NC(=O)CN1C(=O)C2=CC=CC(Br)=C2C1=O CC=1C=CN([C@H1](C)C(=O)NCCC[C@@H1](O)C(=O)N2CCC=3N=CSC=3C2)N=1 COC(=O)[C@H1]1CN(C(=O)C2=CC3=C(S2)CCN(CC4=CC=C(O)C=C4Cl)C3)CCO1 CCCN1N=C(C)C=C1C(=O)N(C)C[C@H1](O)CNC(=O)[C@@H1]2CC23CCC(=O)CC3 CC(C)(C(=O)N1CC[C@]2(C[C@H1]2C(=O)NCCCSCCO)C1)C3CCCC3 O=C(C1=CC(Cl)=CC=C1F)N2[C@H1]3C[C@H1]2CN(CC4=CC5=CC=CC=C5S4)C3 CCN(CCN(CC)C(=O)[C@@H1](CC(C)C)OC)C(=O)CCC=1C=NN(C)C=1 CC[C@@H1](CN(C)C)C(=O)N[C@H1](C)[C@@H1]1C[C@H1]1C(=O)NCC2[C@H1](C)[C@H1]2C O=C(CC1=CN=C[NH1]1)N2CC[C@@](O)(CCNC(=O)C3(N4CCCC4)CC3)C2 CC(C)N1C[C@H1](C(=O)NC2=CC=CC=C2N3CC(N)C3)CC1=O CC(=CC(=O)NC[C@@](C)(O)C1(C)CC1)CNC(=O)C2=CC=NN2C(F)F C=CCCOCC(=O)NC[C@@H1]1CC(F)(F)CN1C(=O)C=2[NH1]N=NC=2COC O=C(N[C@H1]1[C@H1]2C[C@@H1]3[C@H1]1[C@@H1]3[C@@H1]2C(=O)NCC4(CF)CC4)C=5C=N[NH1]C=5 CC[C@@H1](C(=O)N1C[C@H1](F)[C@H1](NC(=O)[C@H1]2CC(=O)N(C3=CC=CC=C3)C2)C1)N(C)C O=C(CO)NCCC(=O)NC[C@H1]1C[C@@H1](C(=O)NC2(CCO)CCCC2)CO1 CCC=1OC=NC=1C(=O)N2C[C@@H1](C(=O)NCCCNC(N)=O)CC2(C)C O=C(NCC1=CN=CN=C1)C2=CC(Br)=CC=C2N3C=CC=C3 CCN1N=NC=C1C(=O)N2CC[C@H1](NC(=O)C3(OC)CCCC3)C2 C[C@@H1]1CSCCCN1C(=O)C2=C[C@H1](O)[C@H1](NC(=O)C3=C[NH1]N=C3C(F)F)C2 CC1=CC=C(NC(=O)C(C)(C)C)C=C1NC(=O)N[C@@H1](CO)[C@@H1]2CCCO2 CC1=CC=C2[NH1]C(C(=O)NC[C@@H1](C)CN(C)C(=O)C[C@@H1]3C[C@H1]3C(F)(F)F)=CC2=C1 O=C(C[C@H1]1SC2=CC=CC=C2NC1=O)NC3=CC=CC=C3N4C=CN=C4C5CC5 CO[C@@H1](CNC(=O)[C@@H1]1C[C@@H1]1F)CN2C=C(C[C@H1](O)C(C)C)N=N2 C#CCSCC(=O)N1CC[C@](CC)(C(=O)N2CCO[C@@H1](CC(N)=O)C2)C1 COC1=CC=C(F)C(Br)=C1C(=O)NC2CN(C(=O)[C@@H1](C)C3CCC3)C2 CC=1N=C(C2=CC=CN=C2)SC=1C(=O)N[C@H1](C)C3=CC=C(OCCF)C=C3 CC1CC(CCC(=O)N2CCC[C@@H1](C)[C@@H1]2CCNC(=O)C3=CC=C(C(F)F)O3)C1 CC=1[NH1]N=C(C(=O)N2CCN(C(=O)[C@@]3(C)CCC(=O)NC3)C[C@H1]2C)C=1F CCC(CC)[C@H1](C)C(=O)N1CC[C@H1](N(C)C(=O)C2=CSC(C)=C2)C1 CSCCC(=O)NC[C@@H1]1N(C(=O)C[C@@](C)(C2CCC2)N(C)C)CCCC1(C)C CC1=NOC(C)=C1CCC(=O)N[C@@H1](C)CCCCNC(=O)C2=CC3=CSC=C3S2 C[C@@H1]1CN(C(=O)[C@]23CCCC[C@@H1]2C3)CC[C@@H1]1CNC(=O)[C@@H1]4CCC[C@@H1]5[C@@H1]4C5(F)F O=C(N[C@@H1]1CN(C(=O)[C@@H1]2CCC[C@H1](O)C2)C[C@@H1]1O)[C@@H1]3CCC[C@@H1]3N4C=CC=C4 C=C[C@H1](C)NC(=NCCN=C1C=CC=N[NH1]1)NC[C@@H1](C2=CC=C(C)C=C2)N(C)C C[C@@H1](CCCNC(=O)CC1(C)OCCO1)NC(=O)[C@H1]2COC3=CC=CC=C32 CCOCCCCC(=O)NC[C@]1(F)COCCN(C(=O)C=2OC(CC)=NC=2C)C1 CC(C)[C@@H1](O)CCNC(=O)C1=CC=C2C(=C1)NS(=O)(=O)C2 C#C[C@H1]1CN(C(=O)C2=CN(C)N=C2COC)CCN1C(=O)[C@@H1](O)CC(C)C CC1=CC(C(=O)NCCNC(=O)CN(C)C(=O)C=2C=COC=2)=CC(Cl)=C1Br CC(C)=C(F)C(=O)N1CCC[C@H1]1[C@H1]2CCN(C(=O)C=3C=CN(CCF)N=3)C2 CCOC[C@@H1](NC(=O)C1=CSC(C)=C1C)C(=O)NC[C@@H1]2CC[C@H1]2CO COC(C)(C)CNC(=O)CCC[C@@H1](C)NC(=O)C#C[C@@H1]1CCOC1 COC(=O)C1=CC(COC(=O)[C@H1]2CC(=O)[C@@H1]2C(F)(F)F)=NO1 CCC1=CC=C(C(=O)NC[C@@H1](C(F)F)N2CCN(C(=O)C3CC(F)C3)CC2)[NH1]1 CCN1CC[C@@H1](NC(=O)CNC(=O)CCCCC2CCCCC2)C1 CC(=CC(=O)N[C@@H1]1CCCN(C(=O)[C@H1]2NC(=O)C[C@H1]2C)[C@H1]1C)CN3CCOCC3 CS[C@@H1]1CN(C(=O)[C@H1]2CCC3=CN=NN3C2)C[C@H1]1NC(=O)C4(O)CCC4 O=C(N[C@@H1]1CN(C(=O)C2=CSN=N2)CC13CC3)C4=N[NH1]C5=C4CCCC5 C[C@H1]1C[C@H1](CNC(=O)C=2C=C(CF)ON=2)CN1C(=O)CN3C=NN=C3 C[C@H1](CN1C=C(C2=CC(Cl)=CC=C2Cl)N=N1)NC(=O)CCOCCOCCCO C=C[C@H1](CC)CC(=O)NC[C@@H1]1CCC2(CCC2)[C@H1]1NC(=O)C3(C(=O)N(C)C)CC3 CC1=NC(Br)=CC=C1NC(=O)[C@@H1]2C[C@H1](F)CN(C(=O)C3=CC=NC(F)=C3F)C2 CC=1OC=CC=1CN(C)C(=NC2CCN(C(=O)C(C)C)CC2)NC3CCC3 COC(=O)C[C@H1](C)C(=O)N1C[C@@H1](C)[C@@H1](NC(=O)C2=CC3=C(S2)CCOC3)C1 CC1=CC=C(C)C(C(=O)N2CCCC[C@H1](NC(=O)[C@H1](C)N3C=CC=C3)C2)=C1 CC(C)(C)N(CC(F)(F)F)C(=O)[C@@H1](N)CC1=CN=CN=C1 O=C(NC1(CNC(=O)[C@@H1]2CN3CC[C@H1]2C3)CCC1)C4=CC=C5OC(S)=NC5=C4 CC[C@@H1]1[C@@H1](NC(=O)CCC=2C=CN(C)N=2)CCCN1C(=O)CC3CCC(C)CC3 COCCCN=C(NC[C@H1](CO)C(F)(F)F)N[C@@H1](C)C1=CC=C(Cl)N=C1OC C=C[C@@H1](CC)CC(=O)N1C[C@H1]2CN(C3=CC=NC(C#N)=N3)C[C@@H1]2C1 CCO[C@@H1]1C[C@@H1]1C(=O)N[C@H1](C)[C@@H1](NC(=O)CN2C=NC(C(N)=O)=N2)C(C)C C[C@@H1](CN1C=CN=C1)C(=O)N2C[C@@H1](NC(=O)COC=3C=NN(C)C=3)CC4(CC4)C2 CC(C)COCC(=O)NC[C@@H1]1C[C@H1]2C[C@@H1](C1)N(C(=O)CC3CC(=O)C3)C2 C[C@@H1]1C(C(=O)N[C@@H1]2CCCCN(C(=O)CN(C)C(N)=O)C2)=CC3=CC=CC=C31 O=C(CC[C@@H1]1CCCO1)NC2(CO)CCN(C(=O)C(F)F)CC2 CCO[C@@H1]1[C@H1](C)[C@H1]1C(=O)NCCO[C@@H1]2CCN(C(=O)CCC3=CC(C)=NO3)C2 CC1=NC2=C(S1)CN(C(=O)C3=CSC(CNCC4=CC(F)=C(F)C(F)=C4)=N3)CC2 CN1N=CC=C1CNC(=O)COC2(C)CN(C(=O)CN3[NH1]C=NC3=N)C2 CC1=C(C(=O)NC[C@H1](C)NC(=O)CC[C@H1]2NC(=O)NC2=O)C=CC=C1S(N)(=O)=O CC1=CC(=O)N(CCC(=O)NC[C@]2(F)C[C@@H1](NC(=O)[C@@H1]3C[C@@H1]3C)C2)C=N1 CC=1SC(C(=O)N2CC=C(CCNC(=O)CC3=CN=CN3C)CC2)=C(C)C=1C CC(Cl)=CC(=O)NC[C@@H1]1CC[C@@H1](C)N(C(=O)C=2N=NN3C=2COCC3)C1 CSC[C@@H1](O)C(=O)NCC[C@@H1](C)NC(=O)C1=CC=CC(C)=C1N CC(=CC(=O)N(C)[C@H1]1CCC[C@@H1](NC(=O)C2(CO)COC2)C1)C3=CC=CC=C3C C[C@@]1(NC(=O)C2=CC(N)=CC([N+1](=O)[O-1])=C2)CCN(C(=O)[C@H1](O)C3CCCC3)C1 C[C@@](CO)(NC(=O)C1CCC(NC(=O)C(Cl)Cl)CC1)C(F)(F)F CC(C)C[C@H1](F)C(=O)N1CCCN(C(=O)C2(C3=C(F)C=CC=C3F)CC2)C[C@@H1]1C CC[C@H1](C)CC(=O)N[C@@H1](C)CCCCNC(=O)COC1=CC(Cl)=CC=C1C CC(C)[C@H1](CN=C1C=CN=C(N2CCC[C@H1](C(F)(F)F)C2)[NH1]1)C3=CC=NN3C CCC[C@@H1](Cl)C(=O)N1CCC[C@H1](C(=O)NCC2=CC=CC(F)=N2)C1 COC(=O)C=1[NH1]C=CC=1C(=O)N2C[C@@H1](C(F)(F)F)C[C@H1]2CNC(=O)C3=CC=CO3 CC1=CC(Cl)=C(C(=O)N[C@@H1]2CN(C(=O)[C@H1](O)C3=CC=CC(F)=C3)C[C@H1]2C(F)F)S1 CS[C@H1]1C[C@@H1](CN=C(NC2CCCC2)N[C@H1](C)C3=CC=CC(NC(C)=O)=C3)C1 CCCCC[C@@H1](O)C(=O)N[C@]1(CO)CCCN(C(=O)C2=CC=C(OC)C=C2O)C1 CCCOCCC(=O)N1CCN(C(=O)C=CC2=CC=C(OC)C=C2C)[C@@H1](C)[C@H1]1C CC1=CC(C(=O)N2C[C@@]3(NC(=O)/C=C/C4=CC=C(Cl)S4)CC[C@H1]2C3)=CS1 CCN(C)CCC(=O)NC[C@](F)(C(=O)NC1=CC=CN=C1C)C(C)C C=C(C)[C@](C)(O)C(=O)N1CC=C[C@H1](NC(=O)[C@@H1]2C[C@H1]2C3=CN=CN3C)C1 CCN1C=C([C@@H1]2CN(C(=O)C(=O)N3CCC[C@@H1](CC(N)=O)C3)CCO2)C=N1 CN(CCNC(=O)CC1=CC=CN=C1)C(=O)[C@H1]2C[C@H1](CF)C2 O=C(O)CN1C=C([C@@H1]2CN(C(=O)COC[C@@H1]3CCOC3)CCO2)N=N1 O=C([C@@H1]1CC[C@@]2(C1)CC2(F)F)N3C[C@@H1](NC4=CC=CC(CF)=C4)C5(CCC5)C3 O=C(C=CC1=CC=C(F)C=C1)N[C@H1]2CC[C@@H1]2NC(=O)C3=CN=C(O)C(Br)=C3 COC(=O)[C@H1](C)C(=O)N1C[C@@H1]2CC[C@H1]([C@@H1]1CO)N2C(=O)C3=CC(Cl)=NS3 C[C@H1](C(=O)NC[C@H1](NC(=O)C1=CC=2C=CSC=2S1)C3=CC=CC=C3C#N)C(F)F CN(CCC1CCOCC1)C2=NC(=NCC=3N=C[NH1]N=3)[NH1]C4=C2CSC4 CC[C@H1](C#N)C(=O)NC[C@H1]1CC[C@H1](CNC(=O)C2=CC=NC=3[NH1]C(C)=NC2=3)CC1 CN(C)CC(=O)N1[C@H1]2CC[C@H1]1CC(F)(CNC(=O)[C@@H1]3CCCCC(C)(C)C3)C2 O=C(CCC=1C=CON=1)N2CCC(C=CC3=CC=C(C4=CC=CC=C4)C=C3)CC2 CCCOC1=CC=C(CN2CCCC[C@@H1]2C3=NN=CS3)C(C)=C1 CC(C)C1=NC(C(=O)N[C@@H1]2CCN(C(=O)CN3C=CN=N3)C[C@@H1]2F)=CO1 CC1=CC=NC=C1C=CC(=O)N2CCC[C@@H1](NC(=O)C3=CC(O)=CC=C3F)C2 CCC(=O)NC[C@H1](C)CNC(=O)C(F)(F)C1=NC=CN1C CCN(CCNC(=O)[C@H1](F)C1CCOCC1)C(=O)C2=CC=C3C(=C2)CCCCN3 CC[C@H1](C(=O)N1CC(C2(NC(=O)C3=NC(C)=NC=C3Br)CC2)C1)[C@@H1](C)O CC1=CC(CC(=O)N(C)C[C@H1]2CCN(C(=O)[C@H1]3CCCC3(F)F)C2)=NN1C CC[C@H1]1CN(C(=O)C2=CC(O)=NC=N2)C[C@@H1]1C(=O)N[C@]3(C)CCCC3(F)F CC1=CC=CC(C(=O)N2CC[C@@H1](OCCNC(=O)[C@@H1]3CC[C@@H1]4C[C@@H1]43)C2)=C1C CC[C@@H1]1CN(CC2=CN=CC(C)=N2)CCN1C(=O)C3=NC=CS3 CC[C@@H1]1C[C@H1](CC(=O)NCC2(C(F)F)OCCO2)CCO1 CCCN1CCC[C@H1]1C(=O)N(C)[C@@H1]2CCC[C@@H1]3CN(C(=O)[C@H1](O)C(C)(C)C)C[C@@H1]32 N#CC1=CC=CC(C(=O)N2CCC[C@H1](C(=O)NCC3=CC=NC=N3)C2)=C1 O=C(N[C@H1]1CC[C@H1](CNC(=O)C2=C(F)C(F)=CC(F)=C2F)C1)C=3C=C(CO)[NH1]N=3 CC(C)OC1=CC=C(C(C)(C)NC(=O)C2=CN=CC(C(=O)O)=C2)C=C1 CC(C)CC1=CC(C(=O)N[C@H1]2C[C@@H1](NC(=O)CC3CCCC3(F)F)C2)=NO1 CCCN1C(C(=O)N2CCC[C@@H1]2CNC(=O)C3(O)CC3)=CC4=CC=CC=C41 CC1=NC(C(N)=O)=CC(N2CCN(C(=O)[C@@H1]3CC(C)(C)[C@H1]3C(F)(F)F)CC2)=N1 C=CC[C@@H1](C)C(=O)N1CC[C@@H1](NC(=O)CCC(=O)OCC)C2(CCC2)C1 CCCC[C@H1](O)CCC(=O)NC[C@@H1]1[C@@H1](C)CCN1C(=O)C[C@@]2(O)CCCOC2 CN(C)[C@H1]1C[C@H1](C(=O)NC[C@@H1]2CCN(C(=O)C(C)(C)CO)C[C@@H1]2O)C1 CC1=CC[C@H1](C(=O)NC[C@@H1]2[C@@H1](C)CCN2C(=O)[C@@H1]3C[C@H1]3C4CCCCC4)CC1 CC=1SC(C(=O)N[C@H1]2CCN(C(=O)C3[C@H1](C)[C@H1]3C)[C@H1](C)C2)=NC=1Br CCC[C@@H1](CC(C)C)C(=O)NCC=1OC=CC=1C(=O)N[C@@H1](CO)CCO C[C@@H1]1ON=C(C(=O)N2CCC(C)(C)[C@@H1](NC(=O)CCC3=CN=CN3C)C2)[C@H1]1C CC1=NSC(N[C@@H1](C(C)C)[C@@H1](C)NC(=O)COCC2=CC=CC=C2)=C1C#N CN(C(=O)C1=CC=2OC=CC=2[NH1]1)[C@](C)(C(=O)NC[C@@H1]3CCCC[C@H1](O)C3)C4CC4 C=CC[C@]1(C(=O)N2CC[C@@]3(C[C@H1]3C(=O)NC4=CC=C(F)C=C4C)C2)CCOC1 CC(C)N1C=C(C(=O)N[C@@H1]2CCOC[C@H1]2C(=O)N[C@@]34CC[C@@H1](C3)[C@H1](O)[C@@H1]4O)C=N1 C#C[C@]1(O)C[C@@H1](C(=O)N2CC3=CC=C(CNC(=O)C[C@@H1]4CC45CC5)C=C3C2)C1 CC1=CC=C(CNC(=O)[C@H1]2CCCN(C(=O)C3CCC(C#N)CC3)C2)C(O)=C1 COCCOC1=CC=CC(CC(=O)N[C@H1](C)CNC(=O)C2=CC=C(F)C=C2Cl)=C1 C=C[C@@H1](COC)N=C1C=CC(Br)=C(S(=O)(=O)N(C)C[C@H1](C)C(C)C)[NH1]1 CCCC1=NC(=N[C@@]2(CO)CCCN(C(=O)C=3OC=C4C=3CCCC4)C2)S[NH1]1 C#CCC(CC#C)C(=O)N[C@H1]1CS(=O)(=O)C[C@@H1]1NC(=O)C=2C=C(SC)OC=2C COC1=CN=C(Cl)C(C(=O)N2[C@@H1]3CN(C(=O)C4(C5=CC=CS5)CC4)C[C@H1]32)=C1 CC[C@H1](CCOC)C(=O)N1CCCN(C(=O)C2=CC(Cl)=CC3=CC=NC=C23)CC1 C#CC[C@@](C=O)N1CCC[C@H1](CC2=CC=C(OC)C=C2)C1 N#CC1=CC=C(Cl)C(C(=O)NCCNC(=O)CC2CC=CC2)=C1 COC1=NC(N2CCC[C@](F)(CNC(=O)[C@H1]3CCNC(=O)C3)C2)=NC=C1C CN1C=NC=C1CC(=O)NC[C@@H1](O)CC(=O)N2CCC3(CC(CO)C3)C2 CC1=CC(C(=O)N[C@H1]2[C@@H1]3CN(C(=O)C4=NC=NC(O)=C4Br)C[C@@H1]32)=NC=N1 CC=1C(Br)=NOC=1C(=O)N[C@@]23CC[C@@H1](C2)N(C(=O)C4=CC=CC=C4F)C3 C[C@H1]1CN(C(=O)CCC2=CN(C)N=N2)C[C@@H1]1NC(=O)C3=C(S(N)(=O)=O)N=CN3C CC[C@](C)(C(N)=O)C(=O)N1C[C@H1](O)C[C@H1]1C(=O)N[C@H1](C)CCCO CCN1C=NC(C(=O)NC[C@]2(CO)CC23CCN(C(=O)CN(C)C(C)=O)CC3)=C1 C[C@H1]1[C@H1](C(=O)N(C)[C@H1](C)CN(C)C(=O)C=2C=CN(CC(F)F)N=2)CCN1C CC1=NN(C)C=C1C(=O)NC[C@H1]2[C@@H1](CN3C=C(C4=CC=CN=C4)N=N3)C2(F)F COCCC(=O)NC[C@@H1](O)CN(C)C(=O)[C@](C)(F)C1=CC=CC=C1F C[C@@H1]1CCC[C@@H1](N(C)C(=O)[C@H1]2C[C@H1](O)[C@@H1](NC(=O)C3=NN(C)C=C3Cl)C2)[C@@H1]1C CC1=CC(N)=C(C(=O)N[C@@H1]2C[C@H1](C)N(C(=O)C3=CN=C(O)N(C)C3=O)C2)N=C1C O=C(CSCC1=CN(C[C@@H1]2[C@H1]3CCC[C@H1]32)N=N1)NC4(C=5C=C[NH1]N=5)CC4 CCC[C@H1](NC(=O)C1=CN=C(C)O1)[C@H1](O)C(=O)NCC=CCOC C[C@H1]1CC2(CCC2)CN1C(=O)[C@H1]3[C@H1](C)OCCN3C(=O)C4CCS(=O)CC4 CC1=CC=C(C(=O)N[C@@H1]2CCC[C@H1]2NC(=O)C[C@@H1](O)C3=CC=CC=C3)N1C CCC1=C(C(=O)N[C@@H1]2C[C@H1]2NC(=O)C3=CC(Cl)=C(F)C=C3Cl)C=CN1C CC1=N[NH1]C(=NC[C@H1](C)NC(=O)[C@@H1]2CCCC3=C[NH1]N=C32)N=C1C CC[C@@H1](NC(N)=O)C(=O)N(C)C[C@@H1](O)CN(C)C(=O)C=1C=NN(C2CCCC2)C=1 C#C[C@H1]1[C@H1](C(=O)N2C[C@@H1](O)[C@H1](N(C)C(=O)C3=CC=C(Br)O3)C2)C1(C)C CCCCC1=NC=C(C(=O)N[C@@H1]2C[C@@H1]2NC(=O)/C=C/[C@H1](C)CC)S1 COC1=NC=C(Cl)C(C(=O)N2CC[C@@H1](O)[C@H1](NC(=O)C3(C)CC(C)C3)C2)=C1Cl C/C=C/[C@H1]1CN(C(=O)C=2C=CN(C)C=2)C[C@@H1]1C(=O)NC3(C)CCC4(CC4)CC3 C#CCC(CC#C)NC(=O)C1=CC2=C(C)C=C(OC)C=C2[NH1]1 CSC[C@](C)(CO)NC(=O)[C@H1](C)[C@@H1]1CCN(C(=O)COC2CC=CC2)C1 CCN(C[C@H1](C)NC(=O)COC1=CC=CC(C)=C1F)C(=O)C2=CC=C(Cl)C=C2 CC1(C)CN([C@H1](C(=O)NCCC#N)C=2C=C[NH1]N=2)[C@H1]1C3=CC=C(Cl)C=C3 CN=C1C=C(C(=O)NC2CC(CO)(NC)C2)C(Br)=C[NH1]1 CC1=CC=C([C@@H1]2CCN(C(=O)NCC3=CC(N)=CC(F)=C3)C2)C=C1 C[C@H1](O)C(C)(C)C(=O)N(C)CCOCCCN(C)C(=O)C(C)(C)C1CCCCC1 CC1=CC(N)=C(C(=O)N[C@@H1]2CCC[C@@H1]2NC(=O)[C@@H1](C)N3C=NC=N3)C(F)=C1 C[C@@]1(N)CCCC[C@@H1]1C(=O)N[C@@H1]2C[C@H1]2C3=CC=C(Cl)C(Cl)=C3 CN1CCO[C@H1](CNC(=O)[C@H1](F)C2(O)CN(C(=O)C=CC=3C=CSC=3)C2)C1 CCC[C@H1](C#N)C(=O)N1CC[C@@](CO)(C(=O)N(C)CCC2=NC=CC=N2)C1 CSCC[C@H1](NC=O)C(=O)NCC1(CCNC(=O)C[C@H1]2CCC(=O)NC2)CC1 CC[C@H1](OC)C(=O)N1[C@H1]2CC[C@@H1]1C[C@H1]2CNC(=O)C3(CC4=CC=CC=C4)CCC3 CC=1[NH1]C=CC=1C(=O)N2CC(C)(C)C[C@@H1]2CNC(=O)CC3(O)CCC3 CC[C@H1](O)C(C)(C)C(=O)N1CCN(C(=O)C2=C(C)C=NN=C2O)CC(C)(C)C1 C[C@@H1](CC(=O)NC1(CF)CN(C(=O)C[C@@H1](C)C(C)(C)C)C1)N2C=CN=C2 CNC(=O)CN1CC[C@H1](CNC(=O)[C@@]2(C3=CC=CC=C3)CCCCO2)C1 CC[C@H1](COC)C(=O)N[C@@H1]1CC[C@H1](CCC(=O)N[C@H1]2CCC[C@@H1]2C(=O)OC)C1 COCC[C@H1](CNC(=O)[C@@H1](C)N1N=CC=C1C)NC(=O)C2C3CCC2CC3 CON=CC(=O)N[C@@]1(C)CCCN(C(=O)C=2C=NN(C)C=2C(F)F)C1 CCC(CC)(C(=O)O)C(=O)NC[C@@H1]1CCCN1CC2=CC(C(=O)O)=CC=C2OC N#CCC1=CC=CC=C1C(=O)NCCC2(NC(=O)[C@H1]3CCC34CCC4)CCCC2 CC=1N=NN(CC(=O)N2C[C@@H1](C)[C@@H1](NC(=O)[C@@H1]3CC4(CO3)CC(F)(F)C4)C2)N=1 CCN1C(CNC2=CC=C([N+1](=O)[O-1])C=C2Cl)=CN=C1Cl CCC1(C(=O)NC[C@H1](CO)NC(=O)[C@@H1](C)NS(=O)(=O)C2=CC=CC(Cl)=C2)CC1 C[C@H1](CCO)C(=O)N1C[C@@H1]2CCC[C@H1](C1)N2C(=O)C3CC4(CCCCC4)C3 COC1=CC=CC2=C1CCN(C(=O)C(=O)NCC3=CC=C(N(C)C)N=C3)C2 CC1=C(C(=O)NCC[C@@H1]2CCCN2C(=O)C3=C[NH1]C(C#N)=C3)N=C4SC=CN14 C=CCN1C(C2=NC=C(CC)C=N2)=NN=C1N(C)CCN3N=CN=C3C(=O)OC CC(=O)OCCC(=O)NC1CC(C)(CNC(=O)C2=CC[C@@H1](C)CC2)C1 O=C1NCC2=C1C=CN=C2C(=O)NC[C@H1]3CO[C@@H1](CN=C4[NH1]N=C(O)S4)C3 CSCC[C@@H1](C)N[C@H1](C1=CC(F)=NC=C1F)C2=NN=NN2C CCC1=CC=C(C(=O)N[C@@H1]2CN(C(=O)C3=CC(C)=NC=N3)[C@H1]4C[C@H1]24)[NH1]1 CC1=C[C@H1](C(=O)N[C@H1]2[C@H1]3C[C@H1](CN(C(=O)CC4=CCCCC4)C3)[C@H1]2CO)SC1 C=C(Cl)C[C@@H1](NC(=O)C1=CC(O)=NC=N1)C(=O)N[C@@H1](C)C(C)(C)CC CON=CC(=O)N1CC[C@H1](C)[C@@H1]1CNC(=O)COC(F)(F)C(F)(F)F COC1=CC=CC([C@@H1]2C[C@H1]2CN3C=C(CN(C)CC4=NC=C(Cl)N4C)N=N3)=C1 CCN(C[C@@H1](C)NC(=O)CC1=CC=C(O)C(C)=C1)C(=O)CC2=CSC(C(C)C)=N2 CC=1C=CN(C)C=1C(=O)NCCC2CC(C(=O)NCC3=NC(C(C)C)=N[NH1]3)C2 CN1C=C(F)C=C1C(=O)N[C@H1](CC(=O)NC2=CSC3=C2CCCC3)CC4=CC=CS4 COC[C@@H1](C(=O)NC[C@H1]1CC(C)(C)CN1C(=O)C=CC2=CC=CO2)N(C)C CC1=NSC=C1CC(=O)N[C@@H1](C(=O)NCC[S@@](C)(=N)=O)C(C)(C)C C#CCC1(C(=O)N2CCN(C(=O)C[C@H1]3CCCC[C@H1]3C)C(CCC)C24CCC4)CC1 COCC(COC)CC(=O)N[C@H1](CC(=O)NCCN1CCC1)CC2CC2 CO[C@H1](CNC(=O)C[C@@H1]1CC2(CC2)CN1C(=O)C3=CN(C(C)C)N=N3)C(C)(C)C CC1=CC(C(=O)N[C@@H1]2CN(C(=O)CCC3=NC=CS3)[C@H1]4CCCC[C@H1]24)=C(O)N=N1 C=CC[C@H1](CNC(=O)CC1=CN=C(C)[NH1]1)NC(=O)C=2C=NN(C(C)(C)C)C=2 COC=1C=C(C(=O)N2CC(CO)(NC(=O)C3=CC4=C(N=N3)OCCS4)C2)[NH1]N=1 CC1=CC(Cl)=CC=C1N2N=C(C3=CC=C(Cl)C=N3)N=C2C4=CC=C5[NH1]C=CC5=N4 CCC=1OC=CC=1C(=O)N[C@H1](CO)CNC(=O)C2=CN=C(N)C(O)=C2 CC[C@@H1]1CCN(C(=O)[C@H1]2CCC[C@H1](C#N)C2)[C@@H1]1C(=O)NN3C=NC=N3 CN1C=C(CC(=O)N2C[C@H1](NC(=O)CSC3=N[NH1]C(O)=N3)[C@H1]4C[C@H1]42)C(Cl)=N1 CC=1SC=C(C(=O)N2CC3=C(CN(C(=O)C[C@H1]4CC4(Cl)Cl)C3)C2)C=1N CC[C@@H1](C)[C@H1](O)CC(=O)N1CCC2(CN(C(=O)C3=NN=C4N3CCCCC4)C2)C1 CC1(C)CCCN(C(=O)CCCC(F)(F)CO)[C@H1]1CNC(=O)C23CCC(C2)C3 CC1=NN=C(O)C(C(=O)N[C@@H1](CN=C2[NH1]C=C(C#N)C=C2C)C3CC3)=C1C CCCN(C)C(=O)[C@H1](C)N1CCN(C(=O)N(C)CC(=O)N(C)C)CC1 CC1=CC(NC(=O)C2(F)CCN(C(=O)[C@@H1]3CCC4(CCC4)O3)CC2)=CC=C1C#N O=C(CCOCC1CCC1)N2CCC3(CC2)CCN(C(=O)[C@@H1](F)[C@@H1]4CCOC4)C3 C[C@@H1](CN(C)C(=O)CCC[C@@H1](C)N(C)C)NC(=O)CN1C=NC(C(F)(F)F)=C1 C=C(C)CC(=O)N[C@@]12C[C@@H1]1CN(C(=O)C3=C[NH1]C(C(F)(F)F)=C3)C2 CCOC(=O)CC(=O)N[C@@H1](COC)C(=O)NC1CC(C)(CC)C1 CC1=CN=C(CCCC(=O)N[C@@H1]2CCC23CCN(C(=O)[C@@H1]4C=CCC4)CC3)O1 CN(CC1(CNC(=O)COC2=CC=C([N+1](=O)[O-1])C=C2)CC1)C(=O)C3=NOCC3 CN1CCO[C@H1](C(=O)N2CC[C@H1](C3CC3)[C@@H1]2CNC(=O)C4=CC=C(O)N=C4Cl)C1 COC[C@]1(C(=O)N2CC[C@@H1](C)N(C(=O)C[C@@H1]3CC[C@H1](O)C3)CC2)C=CCC1 CC(C)C=1C=C(C(=O)N[C@H1]2COCC[C@H1]2NC(=O)[C@H1](C)NC(N)=O)ON=1 C[C@H1](CNC(=O)[C@H1]1C[C@H1](O)C1)N(C)C(=O)[C@@H1]2CCC3(CCC3)O2 C#CC1=CN=CC(NC(=O)[C@H1](CCC=C)NC(=O)C2=CC=C(C(C)=O)O2)=C1 C[C@@H1]1C[C@H1](C(=O)N[C@H1]2C[C@H1](C(=O)N(CC3CCC3)CC4CC4)C2)CN1C C[C@@H1]1CCC[C@H1](C(=O)N2CC(C=3C=NN(C)C=3)C2)C1 C=C[C@@](C)(CC)C(=O)NCCCCCN1C=C([C@@H1](O)C2=CC=C(F)C=C2)N=N1 COC=1C=C(CCC(=O)N2C[C@@H1](COC)C[C@H1]2CNC(=O)C3=NC=CN3C)ON=1 COCCOCC=CC(=O)NCC1=CC(C(=O)NC[C@H1]2[C@@H1]3COC[C@H1]2C3)=CO1 CCN1CCN(C(=O)[C@@H1]2CCCN(C(=O)OC(C)(C)C)C2)CC1 C=C[C@@H1]1OCCC[C@H1]1C(=O)N[C@H1]2C[C@H1](CCNC(=O)C3=NOC4=C3CCCC4)C2 CCN(C[C@@H1]1CCCN1C(=O)C(OC)OC)C(=O)C2=CC=C(C(=O)NC)N=C2 CCOC(CC(=O)N1CCC[C@](C)(CNC(=O)CC(C)(C)O)C1)OCC CC(C)[C@@H1]1C[C@H1](C(=O)N[C@H1](C)CCCNC(=O)C[C@]2(C)CC2(Cl)Cl)CCO1 CO[C@@H1](C1CC1)[C@H1](C)NC2=CC=C(S(=O)(=O)N(C)CCC3=CC=CC=C3)C=C2Br CC[C@@H1]1CC[C@H1](C(=O)N[C@@H1](C)CC2CN(C(=O)[C@@]34CC=CCN3CCC4)C2)O1 CO[C@@H1](C(=O)N1CC[C@H1]1CNC(=O)[C@H1]2C=CCS2)C3=CC=CC=C3 COC(=O)C1=CC(CN2C[C@H1](C3=CC=CC=C3)[C@@H1]4COCC[C@@H1]42)=CC=C1Cl CCN(CC1CCN(C(=O)C=2N=C(C)N(C)N=2)CC1)C(=O)C3=CN=C4N3CCC4 CC(C)N(CCN(C)C(=O)C1(C2=CC=C(Cl)C=C2)CCCC1)C(=O)CCCF C[C@H1](CC(N)=O)C(=O)N[C@H1]1CCN(C(=O)COC2=CC=CC(C(N)=O)=C2)C13CC3 NC1=CC=C(C(=O)N[C@H1](CNC(=O)C[C@@H1]2CC2(Cl)Cl)CC(F)(F)F)N=C1 CCC1(NC(=O)C[C@H1]2CCCC[C@@H1]2O)CCN(C(=O)C=CC3=NC=C[NH1]3)CC1 C=CCCCCCC(=O)N(CC)[C@@H1]1CCN(C(=O)[C@H1]2CCCCCC2(F)F)C1 COC1=CC=C(F)C=C1CNC(=O)C=CS(=O)(=O)C2=CC=C(C)C=C2Cl N#CC1=C[NH1]C2=NC=NC(N(C(=O)C=3C=CSC=3Cl)[C@@H1]4CNCC(F)(F)C4)=C12 CCCC1=CC=C(CNC(=NC[C@H1]2C[C@@H1]3COC[C@@H1]3O2)NC(C)C)C=C1 CCC1=NC=CN=C1C(=O)N[C@@H1]2[C@H1]3C[C@]2(C)CN3C(=O)CC[C@H1]4CCCOC4 CC(C)(CCCNC(=O)[C@@H1]1CCC2=NC=NN2C1)NC(=O)C[C@@H1]3CCC34CCC4 C#CCCCCC(=O)N[C@@H1]1CCCN(C(=O)CCP(C)(C)=O)CC1 C=CC(C)(C)CC(=O)N1C2CCC1(CNC(=O)C=3OC=NC=3C)CC2 CCC1=NSC(N2CCO[C@@H1](CN(C)C(=O)[C@]3(C)COC4=CC=CC=C4O3)C2)=N1 C[C@@H1](CCCCNC(=O)C(C)(C)CCCO)NC(=O)C1=CSC(O)=N1 CO[C@@]1(C(=O)N2CCOC[C@@](F)(CNC(=O)C3=CC(C)=NS3)C2)CCCOC1 CCC[C@@H1](CNC(=O)CCC(C)(C)N(C)C)C(=O)NC1=CC=C2C=COC2=C1 CN1C=C(C=CC(=O)N2CCCC[C@H1]2C(=O)NCC=3C=CN(C)N=3)N=N1 C#CC[C@H1](CC(=O)N1CC[C@@](C)(COC)C1)NC(=O)CC2=CC=NS2 COC1=CC=C(N2N=NN=C2[C@H1](N[C@@H1](C)CCOC(C)(C)C)CC)CC=C1 CC[C@H1](NC(N)=O)C(=O)N[C@@H1]1C[C@@H1](NC(=O)C2=CC(OC)=CC=N2)C[C@H1]1O CCCN(CCNC(=O)C[C@H1]1CCOC1(C)C)C(=O)C[C@@H1]2CCCCC(=O)N2 COC(C)(C)CC(=O)NCC1(NC(=O)[C@H1]2CCC2(F)F)CCC1 COC(OC)C(=O)NCC1=CC=CC=C1CNC(=O)CCCCN2CCCC2 CC1=CC=C(C(=O)N2C[C@@H1]3CC[C@H1](C2)[C@H1](NC(=O)[C@@H1]4CC(=O)N(C)C4)C3)C(N)=N1 C[C@@H1](CNC(=O)C=1C=C(C2CCC2)ON=1)N(C)C(=O)[C@@H1]3CCC[C@H1]3S(C)(=O)=O C#CCCOCC(=O)N[C@H1]1CCOC[C@@H1]1C(=O)NCCC2=NC=C(C)C=N2 CC[C@H1](CNC(=O)[C@@]1(Br)CC1(F)F)NC(=O)CCC2=CN(C)N=N2 CC(C)[C@@H1](C#N)C(=O)N1C[C@@H1](O)[C@H1](N(C)C(=O)C2=CC=C(F)C(F)=C2)C1 CN(C)CC=1C=COC=1C(=O)NC[C@H1]2CC[C@H1]2NC(=O)CCC3=CC=CO3 CC1=CC(C(=O)N2CC[C@@H1](CCNC(=O)[C@@H1](C)S(N)(=O)=O)CC2)=C(C)N1C3CC3 CC1=N[NH1]C(C)=C1[C@@H1](C)C(=O)N[C@@H1](C(=O)OC[C@H1]2CC2(C)C)C(C)C O=C(CN1CC=CC1)N2CC[C@@H1]3C[C@]3(C(=O)N4[C@H1]5COC[C@H1]4C5)CC2 O=C(NCC1(O)CCN(C(=O)C(F)=CC2CC2)CC1)C3=CC=C4SC=CC4=C3 COC(=O)C[C@@H1]1C[C@H1](F)CN1C(=O)C(=O)NC2=CC=C(C(F)(F)F)C=C2[N+1](=O)[O-1] C#CCC[C@H1](NC(=O)[C@@H1]1CCC[C@H1]1OC)C(=O)NC[C@@H1]2CC=CCC2 N#CC1=CC=C(CSCC(=O)NC2CP(=O)(CC(=O)O)CC2)C=C1 CC(Cl)=CC(=O)NC[C@H1]1CCC(C)(C)CN1CC2=NC=C(C(C)(C)C)O2 O=C(C1=CC=C2C(=C1)CC2)NC[C@@H1]3C[C@H1](CNC(=O)C4(C(F)F)CC4)CO3 CC1CC(C(=O)NC[C@@H1](C)CN(C)C2=CC=C(C=C2[N+1](=O)[O-1])N(C)C(=O)N)C1 CC[C@@H1](C(=O)NCC1(C)CCN(C(=O)C=2SC=NC=2C)CC1)C(=O)OC CCC[C@H1](NC(=O)C1=C(F)C=CC(F)=C1F)C2=CN([C@@H1]3CCOC3)N=N2 CC=1N=COC=1C(=O)N[C@H1](C(=O)N[C@H1](C)C2=CC=NS2)C3CC3 C=CCC(C)(C)CC(=O)NC[C@H1]1COC[C@H1]1NC(=O)C2=NN=CS2 CCCCOCC(=O)N[C@H1]1CCCC12CCN(C(=O)CCCCC(N)=O)CC2 CCOCCC1=NC(C(=O)N(C)[C@@H1](C)CCNC(=O)C2=NC=C(C)C=N2)=CO1 C[C@H1](C(=O)N[C@H1]1CCN(C(=O)C(=O)NC2=NC=C[NH1]2)C1)C=3C=NN(C)C=3 CCC1(C2=CN(C[C@@H1]3CCN(C(=O)[C@@H1]4C[C@@]4(F)Cl)C3)N=N2)CCOCC1 CC[C@H1](C)C1=CC=C(C(=O)NC[C@@]23CC[C@@H1](C2)N(C(=O)C=C4CCC4)C3)C=C1 COC(C)(C)[C@@H1](C)NC(=O)[C@H1]1CCC=C[C@H1]1NC(=O)COCCF C[C@@H1](N[C@@H1](C1=CCCCCC1)C2=NN=NN2CC=3N=NN(C)N=3)C4(C)OCCO4 COC1=NC=NC(OC)=C1C(=O)N[C@@H1](C)CN(C)C2=NC3=CC(F)=CC=C3O2 CCCC[C@H1](C)C(=O)N1C[C@](C)(C(=O)N(C)[C@H1](C)C(C)(C)O)CC1(C)C CC1=N[NH1]C(=NC(=O)[C@H1]2COCCN2CC3=CC=C(O)C(Cl)=C3)S1 C=CCC1(NC(=O)CN2C([N+1](=O)[O-1])=CN=C2C)CN(C(=O)C[C@H1](C)CC)C1 COC1=NC(C(=O)N2CCCC[C@]23C[C@H1](NC(=O)C4=NC(O)=C(C)S4)C3)=CO1 O=C(CC1=CC(Cl)=CS1)N[C@@H1]2CC[C@H1]3CCN(C(=O)C4CC5(CSC5)C4)[C@H1]32 CN(CC1CCN(C(=O)[C@@H1](F)CC2=CC=CC=C2)CC1)C(=O)[C@@](C)(O)C(F)(F)F CSC(C)(C)/C=C/C(=O)N[C@@H1]1[C@H1]2CCN(C(=O)CCOC3COC3)C[C@H1]21 CC[C@H1](C#N)C(=O)NCCCCCCN(C)C(=O)CC1=CC=C2C(=C1)COC2 C#CCN(C(=O)C[C@H1]1CCC[C@@H1](NC(=O)COC=2C=CN(C)N=2)C1)[C@H1]3CCOC3 CC(=CC1=CN=C[NH1]1)C(=O)N(C)C[C@@H1](O)CN(C)C(=O)C2=CC=C(C#N)[NH1]2 CNC=1SN=C(C)C=1C(=O)N2C[C@@H1](O)[C@H1](NC(=O)C=3[NH1]C(C4CC4)=NC=3C)C2 CC1=CC(Cl)=CC(C(=O)N2CC[C@@H1](CNC(=O)CCCS(N)(=O)=O)C23CCC3)=C1 C[C@@H1]1CC[C@](C)(NC(=O)[C@@H1]2C[C@H1]3C=C[C@H1]2N(C(=O)CCC(C)(F)F)C3)C1 O=C(CSC1=CC=CC=[N+1]1[O-1])N[C@H1]2[C@@H1]3CN(C(=O)[C@H1]4CC45CCOCC5)C[C@@H1]32 CC[C@@H1]1[C@@H1](NC(=O)C2=COC([C@@H1](C)OC)=N2)CCN1C(=O)C=3[NH1]C=C(C)C=3C CC1=CC=C2N=C(NC(=O)N[C@@H1]3CCC[C@H1](F)C3)C=CC2=C1 CCN(CCOCCO)C(=O)C12CC(C)(CN1C(=O)C3=CN=CO3)C2 O=C(CC1(N2C=CN=C2)CC1)N3CC[C@@]4(CCN(C(=O)CN5CCCCC5)C4)C3 COC1=CC=C(CNC(=O)[C@@H1](C2=CC(Br)=NC=C2F)N(C)CC(C)(F)F)C=C1 C=C(C)COCCNC(=O)[C@@H1](NC(=O)COC1CC=CC1)C2=CC=CC=C2 CCOC(C)(C)C(=O)NC[C@@H1]1CN(C(=O)C2=CC=C([S@@](C)=O)C=C2)C[C@H1]1C COC(=O)[C@H1]1[C@@H1]2C[C@H1]1CN2C(=O)[C@@H1]3CC=CCN3C(=O)[C@@H1](C)[C@@H1](O)C(C)C C=C1COC2=C(C(=O)NC[C@H1](C)N(C)C(=O)[C@@H1](O)CSC)C=NN2C1 O=C1C[C@@H1](C(=O)NCC2=CN(C3CN(C(=O)C=CC4CCCCCC4)C3)N=N2)N1 C[C@@H1](C(=O)N[C@@H1](CC(N)=O)C(=O)N(C)[C@H1](C)CN(C)C)C=1C=CSC=1 C=C1CC(CONC(=O)CCOC2CN(C(=O)C(C(C)(C)OC)COC)C2)C1 CO[C@@H1]1CN(C(=O)C2=NC3=CC=CC=C3O2)C[C@@H1]1NC(=O)C4=CC(C(N)=O)=C[NH1]4 CCCOC1=CC=CC(CC(=O)N(C)[C@H1](C)CN(C)C(=O)C2=C[NH1]C(=N)S2)=C1 CC1=CC=C(CCC(=O)N2CCOC[C@@H1](NC(=O)CC=3C=NN(C)N=3)C2)C(C)=C1 C[C@@H1](NC(=O)[C@@H1]1C[C@@]12CCN(C(=O)C3=CC=C(O)N=N3)C2)[C@H1](O)C(F)F C[C@@H1](NC(=O)C1=CC=C(C2=CC=CS2)S1)[C@@H1]3CCCCN3C(=O)CC=4C=CSC=4 C=C[C@](C)(CC)C(=O)N1CCC([C@H1]2CCCN(C(=O)[C@@H1]3C[C@H1]3OCC)C2)CC1 CC1(C)CCO[C@H1]1CC(=O)NC[C@H1]2CN(C(=O)CCOC3CCC3)CC2(C)C CSCCCC(=O)N[C@@H1]1C=CCN(C(=O)CC2=CC(F)=C(F)C=C2F)C1 CN1N=CC(C(=O)N2CCC23CCN(C(=O)C45CCC(F)(CC4)CC5)CC3C)=N1 C[C@H1](CC(F)F)C(=O)N1CCC[C@](C)(C(=O)NCC2=CN=CC(Cl)=C2)C1 CC=1C=CN(CC(=O)N2CC[C@H1]3CCC[C@]32C(=O)NC4(CO)CC(O)C4)C=1 CCCCOCC(=O)N1CC[C@]2(C[C@@H1](NC(=O)C3=CSC4=CC=CN=C34)CO2)C1 CCCC(=O)NCC(=O)N1[C@H1](C(=O)N(CC2(O)CCC2)C3CC3)C[C@H1]4C[C@H1]41 O=C([C@H1](O)C1=CC=CC=C1)N2CCC[C@@]3(CCCN(CC4=NC=CO4)C3)C2 CN1C=CN=C1C(=O)N[C@@H1]2CN(C(=O)CC3=CSC(Cl)=N3)C[C@H1]2C(F)F CNC1=CC=CC=C1C(=O)N[C@@H1]2C[C@@H1]2CNC(=O)CCN3C=C(C)C=N3 C[C@H1](C1CCCC1)N(C)C(=O)[C@]23CCC[C@H1]2CCN3C(=O)C=4C=NN5C=4OCC5 C[C@@H1](C(=O)N1CC[C@H1]1CNC(=O)CCC2=CN=CO2)C3=CC=C(C#N)C=C3 CSC(C)(C)CC(=O)NC[C@H1]1C[C@@H1](C)N(C(=O)C2=CC3=CC=CC=C3C2)C1 C#C[C@H1](NC(=NCCOC[C@@H1]1CCCO1)NCC2CC2)C(C)(C)C CCN1C[C@@H1](CNC(=O)COC2(C)CN(C(=O)[C@@]3(CC)CCCO3)C2)CC1=O CC1=NSC(N)=C1C2=CN(CCCCCCNC(=O)CC=3N=CN(C)C=3C)N=N2 CC[C@H1](OC)C(=O)NC1(CO)CN(C(=O)[C@H1](CCO)N(C)C)C1 CC1=CC(C(=O)N[C@H1](CNC2=NC=C(I)C=N2)C(C)(C)C)=CC([N+1](=O)[O-1])=C1 CC=1C=CSC=1CC(=O)N[C@@H1]2CN(C(=O)[C@@H1](CO)C3=CC=C(Cl)C=C3)C[C@H1]2O CCSCCCN1N=NN=C1[C@H1](CCCC(C)(F)F)NC2(C3=CC=CS3)CC2 CC(=O)N1CC[C@@H1](CO)[C@@H1](NC(=O)C=2[NH1]N=C([N+1](=O)[O-1])C=2Cl)C1 O=C(N[C@H1]1CN(C(=O)C[C@H1]2CC2(Cl)Cl)CCC13CCOCC3)C4=CSC=N4 CC(C)N(C)CCCC(=O)O[C@H1](C)C1=CC2=C(C=C1[N+1](=O)[O-1])OCCO2 CC(Cl)(Cl)C(=O)NCC1(NC(=O)[C@H1](F)CC2=CC=C([N+1](=O)[O-1])C=C2)CC1 C#CCONC(=O)CCN(CC1CC1)C(=O)C2=CN(C3CC3)C=N2 CCO[C@@H1](C(=O)NCCN(CC)CC1=CC=C(C(C)(C)C)C=C1)C2=CC=CC=C2 CC(C)(CNC(=O)CN1CC[C@H1](C2=CC=C3C=CC=CC3=N2)C1)N=[N+1]=[N-1] CC(C)(C)OC(=O)N[C@H1](C(=O)OCC1=CN=C(Cl)C(Br)=C1)C2C[C@H1]3[C@H1](C2)C3(F)F CC1=CC=C(Br)C(C(=O)N2CC[C@@H1](NC(=O)[C@@]34C[C@@H1](F)[C@@H1]3C4)C2)=N1 C[C@H1](C(=O)NCCCCCCC(=O)NC[C@@H1]1CSCCO1)[C@H1]2CCC(=O)N2 CC#CC[C@H1](NC(=O)[C@@H1]1CCCO1)C(=O)NO[C@H1](C)C2=CC=CC=N2 CCN(C(=O)CCCC1CC1)[C@H1]2CCCN(C(=O)CN3N=CC(Cl)=C3C)C2 CCOC(=O)[C@H1](C(=O)N[C@@H1]1C[C@H1]1NC(=O)C2=CC(C)=C(S(N)(=O)=O)C=N2)C(C)C COCC(=O)N1CC[C@@](O)(C2CCN(C(=O)[C@@]34CC[C@@](C)(C3)OC4)CC2)C1 CCC=1OC(C(=O)N[C@H1]2CCCC[C@@H1]2NC(=O)C3=CC(C)=C(C)C=C3Cl)=CC=1C CCC[C@H1](C#N)C(=O)NC[C@@H1]1C[C@@H1](C)N(C(=O)COC2=CC=CC=C2[N+1](=O)[O-1])C1 CCC(=O)NCCC1(CNC(=O)C=2C=C3C(=O)[NH1]C=CN3N=2)CC1 CCC=CC(=O)N1CCC2=CC=CC=C2[C@@H1](N(C)C(=O)C3=CC(C)=C(CC)S3)C1 CCC1=CC(C(=O)NCC[C@H1]2COCCN2C(=O)CC[C@H1]3CC3(C)C)=CC=C1F CCN(CC)CCC(=O)NC[C@H1](NC(=O)[C@@H1]1C[C@H1]1C2=CC=CC(C)=C2)C(C)C CN(CCOCCN(C)C(=O)[C@@H1]1CC2(CCOCC2)CO1)C(=O)CC(=O)N(C)C COC(=O)CC[C@@H1](C(=O)N1CCOC[C@@H1]1CNC(=O)C=2SC(C)=CC=2C)N(C)C O=C([C@H1](CO)C(F)(F)F)N1CCN(C(=O)COC2CC2)[C@H1](C3=CC(F)=CC=C3F)C1 C=C(C)CCC(=O)N1CCC[C@@H1]1C(C)(C)CNC(=O)CC2=NN=CN2C(C)C C=CC[C@@H1](C)C(=O)N1CCC[C@H1]1C2CCN(C(=O)C3=CC=CN3CCC)CC2 CC1(CNC(=O)[C@H1]2C[C@@H1](O)C2)CN(C(=O)C3=CC=C(I)C(OC(F)(F)F)=C3)C1